不同剂量羟考酮防治二次剖宫产术中牵拉反应的效果

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Abstract Objective To evaluate the effect of different doses of Oxycodone in the treatment of traction reaction during second cesarean section.Methods One hundred and twenty multiparas who underwent second cesarean section in Nanjing Maternity Child Health Care Hospital from October 2019 to December 2020 were selected as the research objects.According to the random number table method,they were divided into O1,O2,O3 and C groups,with 30 cases in each group.After the fetus was delivered,group O1,O2,and O3 were given Oxycodone Hydrochloride Injection 0.08,0.10,0.12 mg/kg,respectively.Group C was given the same dose of normal saline.The mean arterial pressure(MAP),heart rate(HR),saturation of pulse oximetry(SpO2)in the entering the room(T0),before administration(T1),10 min after administration(T2),when exploring the abdominal cavity(T3),and after operation(T4),Ramsay scores at T1,T2,T3 and T4 were compared among the three groups.Results The grading of the pull reaction in groups O2 and O3 were lower than that of the group C,and the differences were statistically significant(P<0.05).There was no statistically significant difference in the grading of traction response between group O1 and group C(P>0.05).There were no statistically significant differences in MAP and HR at T0,T1,T2,T3 and T4 among group O1,O2,O3 and C(P>0.05).The SpO2 level of group O3 was lower than that of group O1,O2 and C at T2,T3 and T4,and the differences were statistically significant(P<0.05).At T1,there was no statistically significant difference in Ramsay scores among the group O1,O2,O3 and C(P>0.05).The Ramsay scores in groups O2 and O3 were higher than those in groups O1 and C at T2,T3 and T4,and the differences were statistically significant(P<0.05).Conclusion After the fetus was delivered,Oxycodone Hydrochloride Injection can provide good sedative and relieve the visceral traction response during the secondary cesarean section.Beyond that,0.10 mg/kg Oxycodone Hydrochloride Injection provides good sedative effect,fully inhibit the visceral traction response,and stabilize maternal vital signs.

Key words： Second cesarean section Continuous epidural anesthesia Oxycodone Visceral traction response Sedative

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	QIAN Xia-li
	CHEN Ya-jie

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QIAN Xia-li,CHEN Ya-jie. Effect of different doses of Oxycodone in the treatment of traction reaction during the second cesarean section[J]. 中国当代医药, 2021, 28(25): 128-131.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2021/V28/I25/128

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