阿戈美拉汀和度洛西汀在首发抑郁症患者治疗中的应用比较

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Abstract Objective To compare the application effect of Agomelatin and Duloxetine in the treatment of first-episode depression.Methods A total of 98 patients with first-episode depression treated in the Department of Psychology of the Fourth People′s Hospital of Yingkou City from November 2018 to November 2019 were selected as the research objects.According to the random number table method,they were divided into group A and group B,with 49 cases in each group.group B was treated with oral Duloxetine,and group A was treated with Agomelatin.Hamilton depression scale(HAMD)was used to evaluate the improvement of depression degree of the two groups before and after treatment.The drug treatment effect of the two groups was evaluated according to the score reduction rate of HAMD after treatment,and the occurrence of adverse drug reactions in the two groups was recorded and analyzed.Results There was no significant difference in HAMD scores between the two groups before treatment(P＞0.05).After treatment,the HAMD scores of the two groups were lower than those before treatment,the differences were statistically significant(P＜0.05).The HAMD score of patients in group A was lower than that in group B,the difference was statistically significant(P＜0.05).The total effective rate of group A was 93.88%,which was higher than 79.59% of group B,the difference was statistically significant(P＜0.05).The total incidence of adverse reactions in group A and group B were 14.29% and 18.37% respectively,and there was no significant difference between the two groups(P＞0.05).Conclusion In the treatment of first-episode depression patients,Agomelatin and Duloxetine have better control effect on depressive symptoms,and the adverse reactions of drugs are less,but in contrast,the efficacy of Agomelatin is more significant.

Key words： Agomelatin Duloxetine First-episode depression Efficacy Adverse reaction

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	SUN Yan
	LIN Dong-mei

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SUN Yan,LIN Dong-mei. Application comparison of Agomelatine and Duloxetine in the treatment of patients with first-episode depression[J]. 中国当代医药, 2021, 28(25): 94-96.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2021/V28/I25/94

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