氢吗啡酮和舒芬太尼用于术后静脉自控镇痛比较的meta分析

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Abstract Objective To evaluate the patient controlled intravenous analgesia effect between hydromorphone and sufentanil.Methods PubMed,Cochrane Library,CBM,CNKI,Wanfang Database,and VIP Database(by October 30,2020)were searched for citations comparing hydromorphone and sufentanil for the patient controlled intravenous analgesia.After screening the citations,extracting data,and evaluating the quality,Revman 5.2 software was used for statistical data analysis.The outcomes included pain score,sedation score,the incidence of nausea and vomiting,itching,and respiratory depression during postoperative.Results A total of 14 studies involving 1161 patients were included.The results showed that the postoperative analgesic effect of hydromorphone was better than that of sufentanil in the elderly,with statistically significant difference（MD=-1.13,95%CI=-1.76- -0.50, P=0.0005）,and there was no difference in the younger（MD=0.19,95%CI=-0.10-0.48, P=0.20）.Compared with sufentanil,PCIA with hydromorphone showed no significant difference in the incidence of postoperative sedation,nausea and vomiting,and itching（MD=-0.16,95%CI=-0.47-0.15, P=0.31, OR=0.83,95%CI=0.53-1.30, P=0.42; OR=0.95,95%CI=0.45-2.04, P=0.9）,but lowered the incidence of respiratory depression,with statistically significant difference（OR=0.28,95%CI=0.11-0.72, P=0.008）.Conclusion Compared with sufentanil,PCIA with hydromorphone has a better analgesic effect in the elderly,and reduce the incidence of respiratory depression.

Key words： Hydromorphone Sufentanil Intravenous Analgesia Meta-analysis

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	FAN Xing
	LIU Hui
	PAN Bing-bing

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FAN Xing,LIU Hui,PAN Bing-bing. Meta-analysis of comparison between hydromorphone and sufentanil in postoperative intravenous controlled analgesia[J]. 中国当代医药, 2021, 28(25): 13-17.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2021/V28/I25/13

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