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Quick Search     Adv Search 2016 Vol. 23, No. 30 Published: 2016-10-28   4 Preparation and toxicity evaluation of triptolide microspheres for intraarticular injection WANG Li-juan；CHE Ke-ke；ZHANG Ru-chao Objective To evaluate the quality and toxicity of triptolide microspheres for intra-articular injection.Methods Triptolide microspheres was prepared by emulsion solvent evaporation method.Surface morphology and size of microspheres were observed by transmission electron microscope.The formation of microspheres was investigated with infrared spectrometer.Entrapment efficiency and drug loading was determined by HPLC.The release of microspheres in vitro was fitted by mathematical model.The toxicity of microspheres was evaluated using hematological parameters and biochemical indexes.Results The microspheres were spherical in shape with uniform size.The mean diameter,encapsulation efficiency and drug loading was 4.75 μm,(74.37±2.30)%and(1.53±0.27)%respectively.The release of microspheres was fit for Ritger-Peppas equation.There were no significant differences of blood test between microspheres and control group.Conclusion Triptolide microspheres might be used as a new preparation for intra-articular injection. 2016 Vol. 23 (30): 4-7转12 [Abstract] ( 134 ) HTML (49 KB)  PDF  (0 KB)  ( 37 ) 8 Study on quality standard of Xiangqi Shengru Mixture HUANG Yi；PAN Tao；TIAN Xia；XIAO Zuo-qi Objective To establish the quality standard of Xiangqi Shengru Mixture.MethodsⅠdentification of main herbal medicines in Xiangqi Shengru Mixture were performed by TLC.The main effective component of paeoniflorin was determined by HPLC.ResultsⅠdentification of Angelicae Sinensis Radix,Chuanxiong Rhizoma,Radix Paeoniae Alba, Aucklandiae Radix and Astragali Radix and so on was established by TLC.The method was simple,the spots were clear with highly specific attribute.HPLC detection results showed that the best detection wavelength was 231 nm,the linear range of the paeoniflorin was 21.1～421.5 μg/ml,the range of the spotting recovery rate was 98.6%,and RSD was 1.7%. Conclusion The method can be used for the quality control of Xiangqi Shengru Mixture,and it is simple,accurate with good repeatability and specificity. 2016 Vol. 23 (30): 8-12 [Abstract] ( 186 ) HTML (45 KB)  PDF  (0 KB)  ( 34 ) 13 Research progress of metabolic syndrome Suyilaqimuge；SU Xiu-lan Metabolic syndrome(MetS)is a complex set of metabolic disorders that increase the risk of cardiovascular atherosclerotic diseases and type 2 diabetes mellitus.Ⅰn addition to traditional definition,there are many different definitions of MetS.A lot of factors have been identified and associated with the syndrome.The impact of MetS on global health issues should be concerned.Ⅰn this review,writers discussed the importance of establishing clear criteria for MetS and analyzed the existing controversy. 2016 Vol. 23 (30): 13-16 [Abstract] ( 155 ) HTML (41 KB)  PDF  (0 KB)  ( 41 ) 17 Clinical application research of CT value in upper urinary calculi CHEN Xiao-hong；RAO Pin-lang；ZHAO Hong Urinary calculi is a common and frequently-occurring disease in Urology Surgery.For the treatment of calculi,along with the progress of science and technology is also more and more,including Chinese medicine row of stone, in vitro ultrasonic lithotripsy,cavity gravel ureteroscopy and percutaneous renal(gravel).Clinically,due to China′s vast, plus economic level,regional difference,for urinary calculi diagnosed is also very different,application of spiral CT in the diagnosis of urinary tract calculi has received clinical identification.Spiral CT can clearly show stone the location,size, shape,CT value(a unit of measurement measured the size of a local tissue or organs density),and avoid the interference of bowel gas etc.,and CT values for the composition of urinary calculi,hardness has good response,in the examination of urinary calculi plays a more and more important role.Ⅰn this paper,CT value in the clinical application of upper urinary calculi is described. 2016 Vol. 23 (30): 17-19转40 [Abstract] ( 172 ) HTML (38 KB)  PDF  (0 KB)  ( 35 ) 20 The application effect of visual nasogastric tube under the general anesthesia induction in the gallbladder laparoscopic surgery CHAO Zi-lian；LIU Xue-hong；MAI Cai-jiu Objective To investigate the application effect of visual nasogastric tube under the general anesthesia induction in the gallbladder laparoscopic surgery.Methods 90 cases of laparoscopic cholecystectomy patients admitted to our hospital from January 2014 to January 2016 were randomly divided into observation group and control group,each group had 45 cases.The success rate and the spending-time of catheterization as well as the general index changes of before and after tube-setting between two groups were compared.The adverse reaction of the nasogastric tube setting was analyzed.Results The success rate of the observation group was 95.56%,which was significantly higher than that of the control group(68.89%),and the difference was statistically significant(P＜0.01).The duration of the observation group was shorter than that of the control group[(3.40±0.38)min vs(4.26±0.58)min],the difference was statistically significant(P＜0.01).Before and after the intubation,the difference of HR,SPO2,MAP indicators in observation group was not statistically significant(P＞0.05).After the intubation,the control group of MAP,HR and before the tube was significantly higher,and higher than that of the observation group after the tube,the difference was statistically significant(P＜0.05).The incidence rate of adverse reaction in the control group was 17.78%,and there was no adverse reaction in the observation group,and the difference was statistically significant between the two groups(P＜0.05).Conclusion The application of visual nasogastric tube under the general anesthesia induction in the gallbladder laparoscopic surgery has a significant effect and can increase the success rate at the fist-time tube-setting,shorten the time of catheter,relieve pain and reduce the incidence of adverse reactions.Ⅰt is worthy of clinical application. 2016 Vol. 23 (30): 20-22 [Abstract] ( 180 ) HTML (35 KB)  PDF  (0 KB)  ( 36 ) 23 Effects of smoking on lung function and urine desmosine with chronic obstructive pulmonary disease XU De-hua；CHEN Xiao-dong；LIU Hua-qing；TANG Ji-wen；YE Miao-qin Objective To explore the effect of smoking on the lung function and urine desmosine with chronic obstructive pulmonary disease(COPD).Methods 60 cases of COPD patients in stable phase admitted in our Hospital from January to June 2016 were divided into COPD smoking group(n=30)and COPD nonsmoking group(n=30),and another 30 healthy people underwent physical examination during the same period were selected as the control group.The levels of urine desmosine of all the cases were measured by indirect competitive enzyme-linked immunosorbent assay(ⅠCELⅠSA),at the same time their lung function was also tested.Results The levels of urine desmosine in COPD smoking group and COPD nonsmoking group was significantly higher than that of the control group respectively(P＜0.05),while FEV1%of the two COPD groups was significantly lower than that of the control group respectively(P＜0.05);the level of urine desmosine of COPD smoking group was significantly higher than that of COPD nonsmoking group(P＜0.05),and FEV1%of COPD smoking group was significantly lower than that of COPD nonsmoking group(P＜0.05).Smoking index was positively correlated with the levels of urine desmosine(r=0.435,P＜0.05),and smoking index negatively correlated with FEV1%and the levels of urine desmosine(r1=-0.516,r2=-0.614,P＜0.05).Conclusion Smoking can lead to the rise of the levels of urine desmosine and the reduce of FEV1%.Changes in urine desmosine suggest the possibility of lung injury.Smoking cessation is an important measure to prevent and interfere with COPD. 2016 Vol. 23 (30): 23-25 [Abstract] ( 145 ) HTML (34 KB)  PDF  (0 KB)  ( 40 ) 26 The effect of noninvasive positive pressure ventilation in the treatment of patients with chronic obstructive pulmonary disease and respiratory failure CHEN Ning Objective To study the clinical effect of noninvasive positive pressure ventilation in the treatment of chronic obstructive pulmonary disease with respiratory failure.Methods From January 2015 to June 2016,100 cases of chronic obstructive pulmonary disease with respiratory failure patients from Emergency Department in our hospital were selected and divided into the control group and the observation group by using the method of random number table,each group had 50 cases.The control group was given routine treatment,and the observation group was treated with noninvasive positive pressure ventilation on the basis of conventional treatment.The oxygen partial pressure(PaO2),carbon dioxide partial pressure(PaCO2),pH index,respiratory rate(RR)before and after the treatment were compared between the two groups,and the death was compared between the two groups.Results After treatment,the PaO2,PaCO2,pH index,and RR between two groups were significantly improved than those before treatment(P＜0.01),and there was a significant difference between the control group and the observation group(P＜0.01).The mortality rate of the observation group(0%) was compared with the control group(4%),the difference was not statistically significant(P＞0.05).Conclusion Noninvasive positive pressure ventilation combined with routine treatment can effectively correct the blood oxygen status and improve the prognosis of patients with chronic obstructive pulmonary disease with respiratory failure. 2016 Vol. 23 (30): 26-28 [Abstract] ( 121 ) HTML (36 KB)  PDF  (0 KB)  ( 36 ) 29 Effect of early enteral nutrition with nutritional status and outcomes for ischemic stroke with dysphagia MA Feng-lan Objective To investigate the effect of early enteral nutrition with nutritional status and outcomes for ischemic stroke with dysphagia.Methods 80 cases of ischemic stroke patients with dysphagia in our hospital from December 2012 to December 2015 were divided into two groups according to the order of admission,each 40 cases.The observation group were implemented with early enteral nutrition,the control group were implemented with gastrointestinal nutrition.The drinking water recovery time,food mouth recovery time,BMⅠ,waist circumference and hip circumference, lipid metabolism,NFⅠrates and life of quality rates(QOL rates)were compared.Results The drinking recovery time in the observation group was(15.8±1.1)days,it was shorter than(32.5±3.9)days of control group(P＜0.01);the oral feeding recovery time in the observation group was(28.9±6.1)days,it was shorter than(46.9±10.2)days of control group(P＜0.01);the BMⅠin the observation group was(24.5±1.0)kg/m2,waist circumference in the observation group was(93.7±2.1)cm,hip circumference in the observation group was(96.7±3.4)cm,they were higher than(22.3±1.1)kg/m2,(89.7±1.6)cm and(94.6±3.2)cm in the control group(P＜0.01);the total cholesterol in the observation group was(4.3±0.3)mmol/L and triglycerides in the observation group was(1.3±0.1)mmol/L,they were higher than(3.9±0.2)mmol/L and(1.2±0.1)mmol/L of control group (P＜0.01);after the intervention NFⅠscore in the observation group was(24.1±1.1)points and QOL score was(11.2±0.6) points,they were significantly lower than(39.5±2.4)points and(18.5±1.3)points of control group(P＜0.01).Conclusion For patients with ischemic stroke,early enteral nutrition can improve swallowing function,improve the body lipid content,promote recovery of neurological function,and improve life quality.Ⅰt has important value. 2016 Vol. 23 (30): 29-31转35 [Abstract] ( 169 ) HTML (38 KB)  PDF  (0 KB)  ( 28 ) 32 Clinical effectiveness analysis of interventional therapy on abdominal aortic aneurysm combining with internal iliac artery aneurysm TAN Gui-fang Objective To explore the clinical effect of interventional therapy on treating abdominal aortic aneurysm (AAA)combining with internal iliac artery aneurysm.Methods 122 cases of AAA combining with internal iliac artery aneurysm in our hospital from January 2015 to January 2016 were selected and divided into the control group(60 cases) and the observation group(62 cases)according to the different therapeutic regimens.The control group was treated with traditional laparotomy,and the observation group was treated with interventional therapy.The incidence rate of complications,surgical time,hospital stay,intraoperative amount of bleeding,time to be off bed after surgery,nursing time in intensive care unit(ⅠCU),normal diet time,and the levels of white blood cell,potassiumion,glutamic-pyruvic transaminase, blood platelet,and urea nitrogen were compared in the two groups.Results The incidence rate of complications in the observation group was 9.68%,which was lower than 23.33%in the control group,with significant difference(P＜0.05).The surgical time,hospital stay,time to be off bed after surgery,nursing time inⅠCU,normal diet time in the observation group was shorter than that in the control group,with significant difference(P＜0.05).The intraoperative amount of bleeding in the observation group was less than that in the control group,with significant difference(P＜0.05).There was no significant difference in the level of white blood cell,potassiumion,glutamic-pyruvic transaminase,blood platelet,and urea nitrogen between the two groups(P＞0.05).Conclusion Application of interventional therapy for patients with AAA and internal iliac artery aneurysm in clinic can obtain a definite effect and a low incidence rate of complications,it is worthy of clinical promotion and application. 2016 Vol. 23 (30): 32-35 [Abstract] ( 141 ) HTML (37 KB)  PDF  (0 KB)  ( 32 ) 36 Related factors analysis of idiopathic ventricular premature contraction induced cardiomyopathy ZHANG Li-yun；MA Shuang Objective To investigate the related factors of idiopathic ventricular premature contraction induced cardiomyopathy.Methods From January 2013 to December 2015,132 patients with frequent ventricular premature contraction who planned to acquire radiofrequency catheter ablation in our hospital were selected.Excluded 36 cases,96 cases were included finally.According to the diagnostic criteria of ventricular premature systolic cardiomyopathy,96 cases were divided into observation group(patients with cardiomyopathy,41 cases)and control group(patients with no cardiomyopathy,55 cases).The general data of the patients were recorded,as well as ECG,24-hour dynamic electrocardiagraphic and the inspection indexes of echocardiogram.The tachycardiomyopathy factors were analyzed by Logistic regression analysis,such as course of disease,ventricular premature contraction load,ventricular premature contraction QRS wave duration,asymptomatic ventricular premature contraction,24 h mean ventricular rate etc..Results Multivariate analysis showed that patients easily obtained premature ventricular contraction-induced cardiomyopathy(PVC-ⅠCM)when they had independent factors including long course of disease,ventricular premature contraction load,ventricular premature contraction QRS wave duration,asymptomatic ventricular premature contraction and 24 h mean ventricular rate increasing(OR=1.036,P=0.029;OR=1.041,P=0.005;OR=1.028,P=0.036;OR=2.377,P=0.044;OR=1.006,P=0.018).ConclusionⅠt is easily to acquire PVC-ⅠCM in patients with pretty large ventricular premature contraction load,long disease course,long ventricular systolic QRS wave duration,and asymptomatic ventricular premature contractions and 24 h mean ventricular rate. 2016 Vol. 23 (30): 36-40 [Abstract] ( 147 ) HTML (44 KB)  PDF  (0 KB)  ( 32 ) 41 Clinical study of slow or no reflow phenomenon in patients with acute myocardial infarction treated by coronary injection for tirofiban LIU Mu-sheng；FAN Hua；WU Ai-yun Objective To investigate the effect of intracoronary injection of plateletⅡb/Ⅲa receptor antagonist on ST elevation acute myocardial infarction(AMⅠ)undergoing percutaneous coronary intervention(PCⅠ)in slow or no reflow thrombolysis in myocardial infarction(TⅠMⅠ)blood flow.Methods 42 cases of PCⅠpatients in the hospital from January 2013 to October 2015 during the period of AMⅠwere divided into two groups according to whether there was slow or no reflow phenomenon during the operation,slow or no reflow phenomenon occurred in the study group(n=12),and there was no slow or no reflow phenomenon as the control group(n=30),patients in the study group were treated with conventional Nitroglycerin,patients with inefficient were treated with intravenous injection of Tirofiban,and Tirofiban after surgery was intravenously maintained;patients in the control group were treated with conventional treatment.The dosage of heparin was 6000 to 10000 U in the two groups.The TⅠMⅠblood flow,ST segment complete drop rate at different times and adverse reactions were compared between two groups after PCⅠ.ResultsⅠnfarction related artery(ⅠRA)in the study group after PCⅠblood flow of TⅠMⅠgrade,compared with that in the control group,had no significant difference(P＞0.05). ST segment drop after PCⅠbetween two groups had obvious difference(P＜0.05).Patients in two groups had no cardiovascular events,3 patients with urine occult blood positive in the research group had improved after reducing heparin. ConclusionⅠntracoronary injection of plateletⅡb/Ⅲa receptor antagonist in the treatment of AMⅠemergency PCⅠwas safe and effective,and its clinical value was significant,and it can be widely used in clinical practice. 2016 Vol. 23 (30): 41-43 [Abstract] ( 144 ) HTML (33 KB)  PDF  (0 KB)  ( 32 ) 44 The application of trans-pedicle internal fixation and intervertebral fusion in the decompression of lumbar spinal cannal stenosis LI De；HU Sheng-li；LIU Xu-feng；WANG Xiao-juan Objective To explore the surgical treatment of trans-pedicle internal fixation spinal canal stenosis and intervertebral fusion in the decompression of lumbar spinal cannal stenosis.Methods From January 2013 to December 2014, retrospective review of 25 cases with lumbar canal stenosis were given surgical treatment.Preoperative they were given routine clinical neural function examination,cinical neural function,lumbar positive side top after flexor stretch power X-ray and MRⅠ.The curative effect were assessed with oswestry disability index before and after operation.Results All 25 cases were followed for 1 to 2.5 years,averaged 1.5 years.ODⅠwas improved from（64.02±7.49）scores to（25.81± 6.92）scores after operation（P＜0.05）.Conclusion The good clinical efficacy can be obtained by trans-pedicle internal fixation spinal canal stenosis and intervertebral fusion. 2016 Vol. 23 (30): 44-46转49 [Abstract] ( 165 ) HTML (33 KB)  PDF  (0 KB)  ( 31 ) 47 Comparison of two minimally invasive ssurgical methods in the treatment of elderly osteoporotic vertebral compression fractures YE Shu-xi；CHEN Rong-chun；YOU Hui；ZHONG Hong-fa Objective To explore the effect of percutaneous vertebroplasty(PVP)and percutaneous kyphoplasty(PKP)in the treatment of elderly osteoporotic vertebral compression fractures.Methods 60 elderly patients diagnosed of osteoporotic vertebral compression fractures from March 2013 to January 2016 in our hospital were selected and divided into two groups.28 patients in the PKP group were treated with PKP,32 patients in the PVP group were treated with PVP. The postoperative Cobb angle correction,the height of anterior vertebral body,the height of posterior vertebral body,postoperative pain,operation time,bleeding volume and complications were compared in the two groups.Results The postoperative Cobb angle correction and the anterior and posterior vertebral height in the PKP group were all better than those of PVP group(P＜0.05);the postoperative pain scores of the two groups during each period had not significant differences(P＞0.05);the operation time and bleeding volume had significant differences(P＜0.05);postoperative complications in the two groups had significant differences(P＜0.05).Conclusion PVP and PKP are effective and safe in the treatment of osteoporotic vertebral compression fractures in elderly patients,and has less complications;PKP has more advantages in restoring vertebral height compared with PVP,and has lower bone cement leakage rate. 2016 Vol. 23 (30): 47-49 [Abstract] ( 165 ) HTML (33 KB)  PDF  (0 KB)  ( 32 ) 50 Clinical efficacy and security of expert tibial nail and locking plate for distal tibial fracture ZHUANG Qiang；LU Shui-sheng；YAN Sheng-jun Objective To explore the clinical efficacy of expert tibial nail and locking plate for distal tibial fracture,and evaluate their security.Methods 70 patients with distal tibial fracture in our hospital from January 2013 to February 2016,were randomly dividied into two groups according to the time sequence of admission,the observation group(n=38) was treated with ETN,and the control group(n=32)was treated with locking plate.All patients were followed up for not less then 6 months.Then the Merchan criteria were used to evaluate clinical efficacy.The excellent and good rate,and complication incidence rates of infection after surgery,malunion after fracture,screw loosening and re-fracture were compared between the two groups.ResultsⅠn Merchan criteria,the good rate of observation group was 94.7%,was significantly higher than that of control group(71.9%)(P＜0.05).The screw loosening(n=1)and the total incidence rate of 7.9% of the observation group were markedly lower than that of control group(P＜0.05).ConclusionⅠn the treatment of distal tibial fracture,ETN is more efficient in clinical efficacy thenlocking plate,and the therapy method of ETN,which has little complication,it is safe and reliable. 2016 Vol. 23 (30): 50-52 [Abstract] ( 121 ) HTML (32 KB)  PDF  (0 KB)  ( 30 ) 53 Analysis of the reamed interlocking intramedullary nail for treatment of nonunion of tibial shaft fractures GONG Wen-qing；CAO Yi；ZHENG Shu-qiao Objective To investigate the clinical practical value of reamed intramedullary interlocking nail for the treatment ofnonunion of the tibial fracture.Methods 22 Patients of nonunion of tibial fracture were selected from July 2012 to October 2015 in our hospital,all patients were treated with reamed interlocking intramedullary nail.They were followed up regularly after surgery,Joher-Wruhs scale were used to assess the function of knee and ankle joint and the effect of treatment.Results All patients were followed up regularly.The mean time of interview was 17.6 months(from 10 to 25 months).22 patients of nonunion of tibial fracture were healed,no infection,deformity and secondary fracture happened.The recovery of illness limb was better,6 months after operation,the results of the Joher-Wruhs scores were 14 cases in excellent,6 cases in good and 2 cases in general,and the excellent rate was 90.9%.ConclusionⅠt has microwound，Fixed stably,less complications that reamed interlocking intramedullary nail for treatment of nonunion of tibial shaft fractures.The probability of nonunion and delayed union decreased,patients can carry out rehabilitation exercises earlier. 2016 Vol. 23 (30): 53-55转68 [Abstract] ( 165 ) HTML (32 KB)  PDF  (0 KB)  ( 38 ) 56 The feasibility,safety and short term clinical efficacy of laparoscopic assisted total rectal excision in the treatment of low rectal cancer XU Jun Objective To explore the feasibility,safety and short term clinical efficacy of laparoscopic assisted total rectal excision in the treatment of low rectal cancer.Methods 114 patients with low rectal cancer treated in our hospital from July 2009 to July 2011 were taken as the research objects and divided into study group and control group according to the different surgical methods,with 57 cases in each group.Patients in the control group were treated with conventional open surgery,while patients in the study group were treated with laparoscopic assisted total rectal excision.The feasibility,safety and clinical efficacy between two groups were analyzed and compared.Results Hospitalization time,exhaust time,catheter indwelling time,operation time and postoperative bleeding volume in the study group was significantly better than that in the control group,and the difference was statistically significant(P＜0.01).After surgery,incidence rate of bleeding,urinary retention,incision infection,urinary tract infection and intestinal obstruction in the study group was significantly lower than that in the control group,and the difference was statistically significant(P＜0.05).After follow-up,1,3,5 year survival rate in the study group was significantly higher than that in the control group（P＜0.01）; the recurrence rate was lower than that in the control group(3.51%vs 12.28%),and the difference was statistically significant(P＜0.01).Conclusion The clinical effects of laparoscopic assisted total rectal excision in the treatment of low rectal cancer are significant,which security is high,and it can make the clinical index obtain effective improvement,and it is positive significance to improve survival rate and reduce recurrence rate,thus it is worth to be promoted. 2016 Vol. 23 (30): 56-58 [Abstract] ( 158 ) HTML (32 KB)  PDF  (0 KB)  ( 36 ) 59 Clinical analysis of Icotinib in treatment of epidermal growth factor receptor sensitive mutations in advanced non small cell lung cancer benefit SUN Yong Objective To explore clinical effect ofⅠcotinib in treatment of epidermal growth factor receptor(EGFR) sensitive mutations in patients with advanced non-small cell lung cancer benefit.Methods 68 patients of EGFR sensitive mutations with advanced non-small cell lung cancer benefit in our hospital from January 2013 to December 2014 were selected and randomly divided into two groups by using single and double number,34 cases in each group.Group A were givenⅠcotinib treatment,patients in group B were were given Gefitinib treatment,overall effective rate,benefit rate,physical status score and incidence of adverse reactions in two groups were compared and observed.Results Overall effective rate was 82.4%in group A,with 76.5%in group B,and the difference was statistically significant(P＜0.05); 1 year benefit rate and physical status score in group A were slightly better than those in group B,and the difference was not statistically significant(P＞0.05),2 years benefit rate was similar between two groups and had no statistical difference(P＞0.05);incidence of adverse reactions in group A were lower than those in group B(P＜0.05).ConclusionⅠcotinib in treatment of EGFR sensitive mutation in patients with advanced non-small cell lung cancer has significant effect,and less adverse reactions,it is worthy of clinical promotion. 2016 Vol. 23 (30): 59-61 [Abstract] ( 152 ) HTML (36 KB)  PDF  (0 KB)  ( 33 ) 62 Observation of clinical efficacy of Docetaxel plus Cisplatin in treatment of patients with advanced head and neck cancer LI Yun；LUO Le；HE Qian；ZHANG Lin；HAN Ya-qian；LIU Feng；LIU Lin；MA Hong-zhi Objective To observe clinical efficacy and toxicity of Docetaxel plus Cisplatin in treatment of patients with advanced head and neck cancer.Methods 58 patients with advanced head and neck cancer in our hospital from December 2013 to December 2015 were divided into observation group(n=30)and control group(n=28)according to different treatment regimen.Patients in the observation group were given with Docetaxel plus Cisplatin treatment regimen, patients in the control group received Fluorouracil plus Cisplatin treatment regimen.The clinical efficacy and toxicity after a month were evaluated and compared between two groups after treatment for one month.Results The response rate in the observation group was 66.7%,higher than 39.3%in the control group,and the difference was statistically significant(P＜0.05).The toxicities of two groups were mainly gastrointestinal reactions,bone marrow suppression,and incidence of gastrointestinal reactions and bone marrow suppression in observation group was obviously lower than that in the control group,and the difference was statistically significant(P＜0.05).Conclusion Patients with advanced head and neck cancer treated by Docetaxel plus Cisplatin chemotherapy can get a more satisfactory clinical efficacy and mild toxicity and it should be introduced in clinical practice. 2016 Vol. 23 (30): 62-64 [Abstract] ( 164 ) HTML (31 KB)  PDF  (0 KB)  ( 32 ) 65 The influence of radical surgery thoracoscope on TNF alpha,IL-6,IL-10 and level of T lymphocyte subsets of patients with early peripheral lung cancer ZENG Xin-min；WANG Hui；ZHANG Zhi-long；HU Huo-li；XU Xing-hua；CHEN Hua Objective To observe the effect of radical surgery thoracoscope on TNF alpha,ⅠL-6,ⅠL-10 and the level of T lymphocyte subsets of patients with early peripheral lung cancer.Methods 78 patients with diagnosed early peripheral lung cancer in our hospital from August 2012 to December 2015 underwent surgery were included in the study and divided into open chest surgery group(n=40)and thoracoscopic group(n=38),patients in the open chest surgery group were treated with conventional thoracotomy,while patients in the thoracoscopic group underwent thoracoscopic resection of early peripheral lung cancer.Change of TNF alpha,ⅠL-6,ⅠL-10 in two groups were compared,and general situation and the differences in the levels of T lymphocyte subsets were compared.Results The level of TNF alpha,ⅠL-6,ⅠL-10 of two groups both improved(P＜0.05),while change of thoracoscopic group was lower(P＜0.05);intraoperative bleeding was less,hospitalization time,drainage tube indwelling time in the thoracoscopic group was shorter,postoperative ambulation time was earlier,and the differences were statistically significant(P＜0.05),there was no statistically significant differences in operative time(P＞0.05);fluctuation amplitude of CD3,CD4,CD8,CD4/CD8 were smaller in the thoracoscopic group(P＜0.05);survival rate of 28 d in the thoracoscopic group was 2.63%,with 5.00%in the open chest surgery group,and the difference was not statistically significant(P＞0.05).Conclusion Compared with conventional thoracotomy, thoracoscopic resection has the characteristics of obvious curative effect,less trauma and quick recovery.Ⅰt is worth popularizing. 2016 Vol. 23 (30): 65-68 [Abstract] ( 138 ) HTML (35 KB)  PDF  (0 KB)  ( 32 ) 69 Safety study and blood glucose regulation of early enteral nutrition for esophageal cancer with diabetes LV Xiu-juan；CHEN Xin；WANG Yan；YU Shan；HUANG Chao Objective To investigate the effect of early enteral nutrition on blood glucose level in patients with esophageal cancer combined with diabetes and its effect on diabetes related complications.Methods 80 cases with esophageal cancer combined with diabetes in our hospital from July 2012 to December 2015 were divided into two group by random number table,each group with 40 cases.Patients in the observation group were given early enteral nutrition and auxiliary parenteral nutrition support,in enteral nutrition Flocare nasojejunal feeding tube was retained to duodenal ligament distal region during operation,patients in control group were implemented with early postoperative parenteral nutrition with intravenous nutrition liquid within one week postoperative.All patients were followed up for 1 month after the intervention,fasting blood glucose,postprandial 2 h blood glucose and glycosylated hemoglobin level between two groups were compared,occurrence rate of ketoacidosis,hypoglycemia,hyperglycemia and hyperosmolar coma after operation in two groups were counted.Results After intervention,fasting blood glucose and postprandial 2 h blood glucose values in the observation group was lower than that in the control group(P＜0.01),glycosylated hemoglobin level was better than that in the control group(P＜0.01),daily average blood glucose fluctuation was significantly less than that in the control group(P＜0.01).Occurrence rate of ketoacidosis,hypoglycemia,hyperglycemia and hyperosmolar coma in the observation group was significantly lower than that in the control group(P＜0.05).The survival rate on the 28 days in the observation group was 90.0%,significantly higher than 65.0%in the control group,and the difference was statistically significant(P＜0.05);the total hospitalization cost was significantly lower than that of the control group(P＜0.01). Conclusion For patients with esophageal cancer combined with diabetes,early implementation with full enteral nutrition can better regulate blood glucose level and reduce diabetes-related complications. 2016 Vol. 23 (30): 69-71转74 [Abstract] ( 177 ) HTML (36 KB)  PDF  (0 KB)  ( 30 ) 72 Clinical efficacy of GP regimen in the treatment of distant metastatic nasopharyngeal carcinoma WANG Fan；YI Jun Objective To observe the short-term efficacy and adverse reaction of Gemcitabine plus Cisplatin(GP regimen)in the treatment of metastatic nasopharyngeal carcinoma(NPC).Methods 46 patients with metastatic NPC treated in our hospital from July 2015 to May 2016 were randomly divided into observation group and control group,23 cases in each group.Ⅰn the observation group,GP regimen was used for intravenous drip chemotherapy,with Gemcitabine 1000 mg/m2,d1,d8;Cisplatin 25 mg/m2,d1-d3.Patients in the control group were given Cisplatin 25 mg/m2,d1-d3;FU 0.75 mg/m2, d1-d5.21 days for a cycle,the whole chemotherapy contained 4 cycles.The therapeutic effect and side effects of the patients were observed.Results The objective effective rate and disease control rate in the observation group was significantly higher than that in the control group(78.26%vs 43.48%;95.65%vs 69.56%)(P＜0.05).The main side effects of two groups were white blood cell reduction,thrombocytopenia,anemia,nausea and vomiting,and elevated aminotransferase.The two groups had no significant difference in the severity of toxicity(P＞0.05).Conclusion GP regimen has a good short-term effect on metastatic NPC,and the toxicity is mild,which can be used as first-line chemotherapy for metastatic NPC. 2016 Vol. 23 (30): 72-74 [Abstract] ( 152 ) HTML (30 KB)  PDF  (0 KB)  ( 26 ) 75 Clinical analysis of 267 cases in medical-indicated preterm labor WANG Hua；MA Xiao-yan Objective To explore the incidence rate,occurrence factor,delivery methods,delivery opportunity in medicalindicated preterm labor and the influence on the prognosis of pregnant women and the newborns.Methods The clinical data of 267 cases of medical-indicated preterm labor in Affiliated Hosipital of Jiangsu University from Jamuary 2012 to December 2015 were analyzed retrospectively.The cause of medical-indicated preterm labor was analyzed.The complications and mortality of medical-indicated preterm labor infants in different pregnanly weeks were analyzed.Results The total incidence rate of medical-indicated preterm labor was 3.33%,accounting for 51.35%of the total recorded preterm births.The top two causes of the medical-indicated preterm labor were antepartum hemorrhage and hypertensive disorders complicating pregnancy.The cesarean section rate of medical-indicated preterm labor delivery was higher than that of natural premature deliver,with significant difference(P＜0.01).The rate of pretem infants suffocation in medical-indicated preterm labor was lower than that in the natural prermature delivery,with significant difference(P＜0.01). The rate of postpartum hemorrhage,death of prematal infants in medical-indicated preterm labor was lower than that of natural premature delivery,with significant difference(P＜0.05).The incidence rate of complication and death rate of preterm infants with gestational weeks greater than or equal to 34 weeks was lower than that of preterm infants with gestational weeks less than 34 weeks,with significant difference(P＜0.01).Conclusion The medical-indicated preterm labor has became the main reason of the preterm birth.Appropriate choice of medical-indicated preterm labor can be beneficical to reduce the mortality of pregnant women and increase survival rate of prenatal infants. 2016 Vol. 23 (30): 75-77转81 [Abstract] ( 131 ) HTML (36 KB)  PDF  (0 KB)  ( 39 ) 78 Analysis of etiology in 156 children with poor growth HONG Qing-rong；GU Shao-qing；XU Li-qin；YE Yuan-feng Objective To explore the etiology in the children patients with poor growth,and to provide reference for clinical diagnosis and treatment.Methods Clinical data of 156 children patients with poor growth from June 2011 to June 2016 were retrospectively analyzed,the cause of the disease was analyzed.Results Among the 156 children patients with poor growth,the average age was(7.43±2.37)years,including 95 boys(61%)and 61 girls(39%).Primary growth hormone deficiency were seen in 68 cases(43.6%),idiopathic pygmyism(suspected)were seen in 45 cases(28.8%),smaller gestational age were seen in 4 cases(2.6%),chromosomal disease were seen in 6 cases(3.8%)(Turner syndrome in 4 cases, other chromosomal abnormalities in 2 cases),intracranial tumors were seen in 10 patients(6.4%)(including postoperative craniopharyngioma secondary to a variety of pituitary hormone deficiency in 1 case,postoperative germ cell tumors secondary to a variety of pituitary hormone deficiency in 1 case,pituitary microadenoma in 8 cases),pituitary stalk breakage was seen in 1 case(0.6%),liver function damage were seen in 10 cases(6.4%),and chronic gastritis were seen in 4 cases(2.6%),congenital heart disease were seen in 3 cases(1.9%),chronic renal failure was seen in 1 case(0.6%), Bartte syndrome was seen in 1 case(0.6%),organic acidemia were seen in 2 cases(1.3%),and psychological affective disorder was seen in 1 case(0.6%).Conclusion Growth hormone deficiency is the most common cause of poor growth in children,however,the etiology of slow growth in children is complicated,and an appropriate treatment protocol should be selected based on different causes of disease. 2016 Vol. 23 (30): 78-81 [Abstract] ( 128 ) HTML (37 KB)  PDF  (0 KB)  ( 39 ) 82 Comparison of the characteristics of neonatal septicemia in preterm and full-term infants HUANG Wei-tang；CHEN Guang-ming；WANG Jie-san；FENG Ming-hua Objective To explore the clinical characteristics of different types of neonatal sepsis.Methods The hospitalization data of 131 cases of newborns were collected from July 2013 to June 2015 in the Neonatal Department of Bo-Ai Hospital of Zhongshan City,all patients were grouped according to the data,and the clinical situation of different types of neonatal sepsis were compared.Results The incidence rate of jaundice and abdominal distension in preterm infants was higher than that in full-term infants,with significant difference(P＜0.05).There was no significant difference in other conditions such as laboratory tests,bacterial distribution in the two groups(P＞0.05).Conclusion Good care during pregnant women and perinatal to avoid complications,early identification of neonatal jaundice,abdominal distension and other clinical manifestations,blood culture done in time to early diagnosis and appropriate antibiotic treatment are helpful to improve the survival rate of neonatal survival. 2016 Vol. 23 (30): 82-84 [Abstract] ( 124 ) HTML (35 KB)  PDF  (0 KB)  ( 36 ) 85 Observation of clinical efficacy of Cetirizine Drops combined with Compound Glycyrrhizin in the treatment of pediatric allergic purpura LUO Pei-yi；CHEN Jin-ping；LIN Xue-yi Objective To explore the clinical efficacy of Cetirizine Drops combined with Compound Glycyrrhizin in the treatment of pediatric allergic purpura.Methods The clinical data of 100 children patients with allergic purpura who were admitted to our hospital from January 2012 to December 2015 were analyzed retrospectively,according to the difference of treatment,all patients were divided into the western medicine group and the traditional Chinese medicine and western medicine group,50 cases in each group.The western medicine group was treated with Cetirizine Drops,the traditional Chinese medicine and Western medicine group was treated with Compound Glycyrrhizin on the basis of the western medicine group.The therapeutic effect,side effects and the level ofⅠgE,ⅠgA andⅠgG were compared between the two groups before and after intervention.Results The total effective rate of the traditional Chinese medicine and Western medicine group was higher than that of the western medicine group,with significant difference(P＜0.01).The level ofⅠgE,ⅠgA andⅠgG after intervention in the two groups was better than that before intervention,with significant difference (P＜0.05).The level ofⅠgE,ⅠgA andⅠgG after intervention in the traditional Chinese medicine and Western medicine group was better than that in the western medicine group after intervention,with significant difference(P＜0.05).There was no significant difference in the incidence rate of side effects between the two groups(P＞0.05).Conclusion Cetirizine Drops combined with Compound Glycyrrhizin has exact curative effects in the treatment of pediatric allergic purpura,which can effectively improve the clinical symptoms of children,improve the immunity,and curb the side effects, which is safe and it is worthy of clinical promotion and application. 2016 Vol. 23 (30): 85-87 [Abstract] ( 128 ) HTML (34 KB)  PDF  (0 KB)  ( 33 ) 88 Clinical analysis of Double Azole Tai Cotton Plugs combined with traditional Chinese medicine washing and Dingjunsheng in the treatment of colpitis mycotica ZHANG Xiao-chun Objective To explore the clinical effect of Double Azole Tai Cotton Plugs combined with traditional Chinese medicine washing and Dingjunsheng in the treatment of colpitis mycotica.Methods 98 patients with colpitis mycotica in our hospital from January 2015 to January 2016 were selected and randomly divided into the experimental group and the control group,49 cases in each group.The control group was treated with Double Azole Tai Cotton Plugs,while the experimental group was treated with Double Azole Tai Cotton Plugs combined with traditional Chinese medicine washing and Dingjunsheng(with 1 granule in the posterior fornix of vagina one day).The treatment effect was compared between the two groups.Results The Traditional Chinese medicine syndrome score of the experimental group was(16.7± 6.2)points,which was lower than(25.8±5.2)points of the control group,with significant difference(P＜0.01).The treatment total effective rate of the experimental group was 97.9%,which was higher than 85.7%of the control group,with significant difference(P＜0.05).The recurrence rate of the experimental group was 4.1%,which was lower than 18.4%of the control group,with significant difference(P＜0.05).Conclusion The application of Double Azole Tai Cotton Plugs combined with traditional Chinese medicine washing and Dingjunsheng in the treatment of colpitis mycotica has better treatment effect,with a low recurrence rate. 2016 Vol. 23 (30): 88-90 [Abstract] ( 142 ) HTML (37 KB)  PDF  (0 KB)  ( 32 ) 91 Evaluation of the value about the treatment of Montelukast Sodium in children with asthmatic bronchitis ZHENG Ya-wen；CUI Zhi-liang；CHENG Ka-mi；ZHU Yue-e；TANG Liang Objective To explore the clinical effect of Montelukast Sodium in the treatment of pediatric asthmatic bronchitis.Methods 100 cases of pediatric asthmatic bronchitis in our hospital from January 2012 to December 2015 were selected and divided into the control group and the observation group according to the random number table method,50 cases in each group.The control group was given routine symptomatic treatment,the observation group was given Montelukast Sodium on the basis of the routine symptomatic treatment for 4 weeks.The clinical total effective rate,disappeared time of cough,wheeze disappeared time,wheezing disappearance time,hospitalization time and inflammatory markers were compared between the two groups.Results The total effective rate in the observation group was 96%, which was higher than 80%in the control group,with significant difference(P＜0.05).The cough disappeared time,wheezing rale disappearance time,wheezing disappearance time,hospitalization time in the observation group was shorter than that in the control group,with significant difference(P＜0.01).The level of C reactive protein and white blood cell count after treatment in the two groups was lower than that before treatment,with significant difference(P＜0.01).The level of C reactive protein and white blood cell count after treatment in the observation group was lower than that in the control group after treatment,with significant difference(P＜0.01).Conclusion The using of Montelukast Sodium in the treatment of pediatric asthmatic bronchitis has remarkable clinical curative effect,which can effectively alleviate the patient′s clinical symptoms,restrain the airway inflammation. 2016 Vol. 23 (30): 91-93 [Abstract] ( 151 ) HTML (34 KB)  PDF  (0 KB)  ( 41 ) 94 Clinical study of after image comprehensive therapy treating amblyopia LUAN Li-juan；ZHANG Fu-sheng；TANG Peng-jun；YANG Gen-lan Objective To discuss the clinical effect of after image comprehensive therapy treating amblyopia.Methods 178 cases with amblyopia(220 eyes)treated by our hospital from September 2012 to September 2015 were selected and they were divided into control group(69 cases,88 eyes)and treatment group(109 cases,132 eyes).Patients in control group were treated by conventional amblyopia treatment while patients in treatment group were treated by after image comprehensive therapy on the basis of control group treatment.Clinical effect,the time of visual acuity level return to normal and incidence of adverse reaction between two groups was compared respectively.Results The clinical effect of treatment group was significantly better than that of control group,the time of visual acuity level return to normal in treatment group was significantly shorter than that of control group(P＜0.05).The incidence rate of adverse reaction in treatment group was significantly lower than that in control group(P＜0.05).Conclusion Clinical effect of after image comprehensive therapy treating amblyopia is very obvious. 2016 Vol. 23 (30): 94-95转99 [Abstract] ( 131 ) HTML (32 KB)  PDF  (0 KB)  ( 32 ) 96 Analysis of multifocal electroretinogram in different degree of myopia LIU Jing；ZENG Xiang-yun；LIU Yan-fang Objective To explore the difference of multifocal electroretinogram between different degree of myopia and normal subjects.Methods 135 cases(255 eyes)given multifocal electroretinogram examination in our hospital from January 2013 to December 2015 were selected as study object and they were divided into 22 cases with 44 eyes in normal group,39 cases with 78 eyes in mild myopia group,31 cases with 62 eyes in moderate myopia group,28 cases with 56 eyes in high myopia group and 15 cases with 15 eyes in high myopia with contralateral retinal detachment group were examined by multifocal electroretinogram.The reaction density of each annular region in retinal during the first order reaction,latent time and amplitude of P1 wave,and the 3D model of the whole reaction density of retina among 5 groups was compared respectively.Results There were significant differencein the reaction density of each annular region in retinal during the first order reaction,and amplitude of P1 wave among 5 groups(P＜0.05).With the increasing of the degree of myopia,the reaction density of each annular region in retinal during the first order reaction,and amplitude of P1 wave all decreased.There were significant differencesin latent time of P1 wave in the first ring among 5 groups(P＜0.05),but no significant differences(P＞0.05)in the second to sixth ring.Ⅰn the first ring,with the increasing of the degree of myopia,the latent time of P1 increased.There were significant differences between the high myopia with contralateral retinal detachment group and the high myopia group(P＜0.05).There was significant difference(P＜0.05)in the reaction density of retina among 5 groups.The degree of myopia was negatively correlated with the whole reaction density of retina (r=-0.507,P=0.011).Conclusion Using multifocal electroretinogram to monitor retinal function in myopic patients is helpful to find and assess early occult fundus change,and it can help to judge the prognosis and prognosis. 2016 Vol. 23 (30): 96-99 [Abstract] ( 111 ) HTML (35 KB)  PDF  (0 KB)  ( 42 ) 100 Clinical efficacy observation of endoscopic nasal cavity lacrimal sac anastomosis in the treatment of congenital lacrimal sac mucus cyst DING Yong；LI gang；LI Yue-xiang Objective To investigate the clinical effect of endoscopic nasal cavity lacrimal sac anastomosis in the treatment of congenital lacrimal sac mucous cyst.Methods 69 cases with congenital lacrimal sac mucus cyst treated by our hospital from February 2014 to July 2015 were selected and given statistical analysis.According to the treatment methods,they were divided into the control group(34 cases)and the observation group(35 cases).Patients in the control group were treated with conventional ophthalmic surgery,while patients in the observation group were given endoscopic nasal cavity lacrimal sac anastomosis.Treatment effect between two groups was observed and compared.Results The total effective rate of control group was 73.5%,while it was 100.0%in the observation group,the total effective rate of the observation group was significantly higher than that of the control group(P＜0.01).After patients were followed-up for 6 months,there was narrowing stoma,unobstructed lacrimal duct,and there was no granulation growth,scar reducing.Treatment satisfaction in the control group was 61.8%,the observation group was 94.3%,and the satisfaction of the observation group was significantly higher than that of the control group(P＜0.01).Conclusion The clinical effect of endoscopic nasal cavity lacrimal sac anastomosis in the treatment of congenital lacrimal sac mucus cyst is prominent,and it is worth popularizing. 2016 Vol. 23 (30): 100-102 [Abstract] ( 110 ) HTML (32 KB)  PDF  (0 KB)  ( 37 ) 103 Analysis of type and treatment for secondary glaucoma caused by ocular contusion YAO Run-lian Objective To investigate the main type and effective treatment strategy of secondary glaucoma caused by ocular contusion.Methods 64 cases with secondary glaucoma caused by ocular contusion diagnosed and treated in our hospital from January 2013 to January 2016 were selected.The clinical type,treatment methods and clinical effect were analyzed.Results Hemorrhage type was 39 cases,37 cases were effective after treatment,and the effective rate was 94.87%;a total of 13 cases of dislocation of the lens after treatment,11 cases were effective,and the effective rate was 84.62%;a total of 6 cases of adhesion proliferation after treatment,5 cases were effective,the effective rate was 83.33%; the chamber angle contusion type was 8 cases,7 cases were effective,and the effective rate was 87.50%.After treatment, intraocular pressure of above-mentioned five types of secondary glaucoma caused by ocular contusion were significantly lower than those before treatment(P＜0.01).There was no light perception in 1 case,light sense-0.05 in 11 cases,light sense of 0.05-0.30 in 13 cases and light sense of＞0.30 in 39 cases.After 6 months of follow-up,visual acuity was increased in 35 cases(54.69%),unchanged in 24 cases(37.50%),decreased in 5 cases(7.81%)compared with leaving hospital.Conclusion Ocular contusion is easy to cause secondary glaucoma,clinical treatment should be based on the specific somatotype to take targeted measures to effectively reduce the intraocular pressure,improve the patient's visual acuity. 2016 Vol. 23 (30): 103-105 [Abstract] ( 134 ) HTML (35 KB)  PDF  (0 KB)  ( 38 ) 106 Dexmedetomidine for combined spinal epidural anesthesia by abdominal myomectomy clinical effect of intraoperative YU Cui-e；WANG Jin-hua Objective To explore the effects of Dexmedetomidine in spinal epidural anesthesia in myomectomy in sedative effect.Methods 62 cases of uterine fibroids were selected in our hospital from September 2014 to September 2015, they were divided into observation group and control group,31 cases in each group,according to the odd and even number of the length of hospitalization.The observation group was given combined spinal epidural anesthesia assisted with Dexmedetomidine,the control group was given combined spinal epidural anesthesia assisted midazolam,the vital signs, sedative effect and adverse reaction of two groups were compared.Results Before anesthesia and postoperative HR,BⅠS, Ramsay scores of two groups were compared,with no significant differences(P＞0.05);the two groups of 30 min,Ramsay in the observation group were higher than before anesthesia and control group,with significant differences(P＜0.05),the HR and BⅠS of observation group were lower than before anesthesia and control group,with significant differences(P＜0.05);the adverse effects of the two groups,the observation group was 16.13%,slightly lower than 19.35%of control group,but no significant difference(P＞0.05).Conclusion Uterine myoma resection anesthesia with Dexmedetomidine and combined spinal epidural anesthesia operation,sedative effect is good,it is worthy of promotion. 2016 Vol. 23 (30): 106-108 [Abstract] ( 126 ) HTML (32 KB)  PDF  (0 KB)  ( 36 ) 109 Application of nerve stimulator in interscalene brachial plexus block LI Wen-hui；RUAN Kai-shen；LI Kun Objective To explore the application effect of nerve stimulator in interscalene brachial plexus block.Methods From May 2015 to May 2016,64 patients undergone upper limb surgery treated by our hospital were selected.According to different anesthetic method for block in interscalene brachial plexus,they were evenly divided into two groups：control group(traditional blind probe for block anesthesia，n=32)and research group(nerve stimulator for block anesthesia，n=32).The block effect and related indexes between groups was compared respectively.Results After 15-minute anesthetization,VAS score was(0.66±0.43)points in research group and(2.26±0.95)points in control group.The onset time of block was(11.71±2.52)min in research group and(14.77±4.36)min in control group.With regard to incidence rate of adverse reaction in research group,it was 3.13%(1/32),while in control group,the rate was 18.75%(6/32). The above-mentioned index in research group was superior to that in control group with a statistical difference(P＜0.05).Conclusion Nerve stimulator can accurately locate the neural position,and microcurrent stimulation can facilitate drug absorption,shorten the onset time of block,and avert the adverse reaction due to drug stagnation. 2016 Vol. 23 (30): 109-111 [Abstract] ( 115 ) HTML (33 KB)  PDF  (0 KB)  ( 29 ) 112 Safety analysis of analgesia using Lornoxicam after anterior cruciate ligament reconstruction GONG Shi-guo；SHEN Xin；LIU Mu-zi；XIE Rong-hui；LIAO Jian-ping Objective To investigate the clinical efficacy and safety of analgesia using Lornoxicam after anterior cruciate ligament reconstruction to provide more reference value for clinic.Methods 28 cases with anterior cruciate ligament reconstruction and postoperative pain treated by our hospital from September 2013 to September 2015 was retrospectively analyzed.They were divided into two groups,and control group was given Dezocine while observation group was given Lornoxicam.VAS score,analgesia satisfaction and incidence of adverse reaction in patients between two group was compared respectively.Results Compared with before treatment,VAS score after 6 h,12 h,18 h and 24 h was significantly lowered and the difference was statistically significant(P＜0.05).Ⅰncidence rate of adverse reaction of observation group(7.14%)was significantly lower than that of control group(42.86%),and the difference was statistically significant (P＜0.05).Good and excellent satisfaction in patients of observation group(85.71%)was significantly higher than that of control group(42.86%),and the difference was statistically significant(P＜0.05).Conclusion The clinical efficacy of Lornoxicam treating postoperative pain after anterior cruciate ligament reconstruction is better,and it effectively reduce the incidence rate of adverse reaction with higher safety,it is worth to be popularized and applied in clinic. 2016 Vol. 23 (30): 112-114 [Abstract] ( 123 ) HTML (31 KB)  PDF  (0 KB)  ( 34 ) 115 Influence of esophageal echocardiography combined with pulmonary artery catheter on surgery effect of the patients with heart valve disease complicated with coronary heart disease XIAO Lu；SU Xin-juan；HU Jie▲ Objective To explore the influence of esophageal echocardiography combined with pulmonary artery catheter on surgery effect of the patients with heart valve disease complicated with coronary heart disease.Methods 30 patients with heart valve disease complicated with coronary heart disease underwent surgery in our hospital from January 2012 to January 2014 were selected as the control group,30 patients with heart valve disease complicated with coronary heart disease underwent surgery in our hospital from Februry 2014 to January 2015 were selected as the experimental group. The experimental group was given esophageal ultrasound before surgery,the floating catheter was placed,and the valve and cardiac function were evaluated.The control group was given preoperative echocardiography,no other special monitoring methods were given.Preoperative,intraoperative,postoperative circulation fluctuation andⅠCU residence time and postoperative review were compared between the two groups.Results The difference of mean arterial pressure(MAP)in the experimental group was lower than that in the control group,with significant difference(P＜0.05).The postoperativeⅠCU residence time in the experimental group was shorter than that in the control group,with significant difference(P＜0.05).The transformation rate of the experimental group was 96.7%,which was higher than 80.0%of the control group, with significant difference(P＜0.05).Conclusion Esophageal ultrasound combined with pulmonary artery catheter can enhance the circulation management of patients with heart valve disease complicated with coronary heart disease,reduce the postoperativeⅠCU residence time,which is beneficial to the patient′s prognosis. 2016 Vol. 23 (30): 115-117 [Abstract] ( 131 ) HTML (35 KB)  PDF  (0 KB)  ( 39 ) 118 Clinical value of real-time three-dimensional ultrasound surface combined with transparency imaging mode in the diagnosis of fetal malformations CHANG Hong-mei；CHANG Hong-tao Objective To explore the clinical value of real-time three-dimensional ultrasound surface combined with transparency imaging mode in the diagnosis of fetal malformations.Methods 202 pregnant women who were given twodimensional and three-dimensional ultrasound examination from July 2014 to July 2015 in our hospital were selected as the research objects,all pregnant women were pregnant for 16-38 weeks,and were diagnosed by three-dimensional ultrasound surface and transparent imaging.The accuracy,specificity and sensitivity of two-dimensional and three-dimensional ultrasound diagnosis were analyzed and calculated.Results 24 malformations were detected in this study,16 lesions(66.67%)were correctly diagnosed by two-dimensional ultrasound,8 lesions(33.33%)were missed diagnosis;21 lesions(87.50%)were correctly diagnosed by three-dimensional ultrasound,3 lesions(12.50%)were missed diagnosis. There was significant difference in the correct diagnosis rate between two-dimensional and three-dimensional ultrasound diagnosis(P＜0.05).202 pregnant women examined in this study,52 cases of malformations were confirmed after birth and induction of labor,among them,12 cases were diagnosed by two-dimensional ultrasound,190 cases had no fetal malformation,there were 9 cases of fetal malformation and 193 cases of no fetal malformation after induced labor or after birth.16 cases of fetal malformation were diagnosed by three-dimensional ultrasound,186 cases had no fetal malformation,there were 15 cases of fetal malformation and 187 cases of no fetal malformation after induced labor or after birth.The sensitivity of two-dimensional ultrasound diagnosis was lower,and the sensitivity was 90.35%,the specificity was 94.74%,and the accuracy was 100.00%.Conclusion The real-time three-dimensional ultrasound surface and transparent imaging mode can make up for the deficiency of two-dimensional ultrasound in diagnosis of fetal malformations,improve the diagnosis accuracy of fetal malformations and play an active role in promoting prenatal diagnosis of fetal malformations,which is worthy of clinical promotion and application. 2016 Vol. 23 (30): 118-120 [Abstract] ( 132 ) HTML (31 KB)  PDF  (0 KB)  ( 30 ) 121 Value of the upper abdominal transection in antenatal sonographic diagnosis of atrial heterogeneous syndrome WANG Rui-jie Objective To explore the clinical value of the upper abdominal transection in antenatal sonographic diagnosis of atrial heterogeneous syndrome,so as to analyse the prenatal sonographic characteristics of fetal upper abdominal transverse section and its relationship with heterogeneous deformity.Methods Ultrasonographic characteristics of upper abdominal transverse section according to the fetal echocardiography diagnosed as left or right atrial heterogeneous syndrome in Materal and Child Health Hospita of Xuzhou city from March 2013 to September 2016 were retrospectively analysed,analysis included the relative relation and position of abdominal large vessels,the position of the stomach,the position of the gallbladder,morphology of liver and the characteristics of portal venous sinus.Results All the 23 cases of atrial heterogeneous fetus had changes in the upper abdominal transverse section,9 cases of left isomerism had interruptedⅠVC and broadened azygos vein(100%in the 9 cases of the left arial syndrome),14 cases of right isomerism with juxtaposition of the abdominal aorta and inferior vena cava(100%in the 14 cases of the right arial syndrome).22 cases showed the level of liver and the position changes of stomach and gallbladder(95.7%in the 23 cases of arial syndrome),1 case of left isomerism showed stomach bullle and gallbladder normal position(4.3%in the arial syndrome, 11.1%in the left arial syndrome).Conclusion Sonographic changes of fetal upper abdominal transverse section,especially the changes in the arrangement of abdominal large vessels have important value in the atrial heterogeneous syndrome. 2016 Vol. 23 (30): 121-124 [Abstract] ( 143 ) HTML (36 KB)  PDF  (0 KB)  ( 28 ) 125 Comparative analysis of value of X-ray,CT and MRI in the diagnosis of lumbar disc herniation WANG Jing-peng；HU Han-ming；ZOU Nan-an；WU Qi-heng；WANG Ai-hua Objective To compare the diagnostic accuracy and clinical value of X-ray,CT and MRⅠin lumbar disc herniation.Methods 74 patients with lumbar disc herniation in our hospital from January 2015 to March 2016 were selected and received X-ray,CT and MRⅠthree kinds of imaging examination.The diagnostic value of the three methods were compared and analyzed,and the imaging findings of lumbar disc herniation were summarized.ResultsⅠn 74 patients with intervertebral disc protrusion,the detection rates of X-ray,MRⅠand CT was 21.62%,74.32%and 87.84%,respectively. The detection rate of X-ray examination was lower than that of MRⅠand CT examination,with significant difference(P＜0.05).The detection rate of MRⅠwas higher than that of CT,with significant difference(P＜0.05).Conclusion The accurate rate of MRⅠin the diagnosis of lumbar disc herniation is better than X-ray and CT,but the length of scan time and high price also become the short board.CT is more applicable to clinical,and it is more sensitive than x-ray.When there are large differences in the results of CT examination,which should be combined with MRⅠto improve the detection rate of complementary. 2016 Vol. 23 (30): 125-127转139 [Abstract] ( 144 ) HTML (36 KB)  PDF  (0 KB)  ( 33 ) 128 Analysis on the effect of Metoprolol combined with Trimetazidine in treatment of coronary heart disease and heart failure LI Ben-xiang Objective To investigate the clinical effect of Metoprolol combined with Trimetazidine in the treatment of coronary heart disease(CHF)and heart failure.Methods 78 patients with CHF and heart failure who were admitted to our hospital from October 2013 to October 2015 were randomly divided into observation group(n=39)and control group (n=39).The two groups were given conventional therapy,the observation group on this,basis combined with Metoprolol, Trimetazidine treatment,the clinical indicators of the changes between two groups was compared.Results The total effective rate was 94.87%in the observation group and higher than 76.92%in the control group,the difference was significant(P＜0.01).There were significant differences in cardiac function between the two groups(P＜0.01).The incidence of adverse reactions was significantly lower in the observation group than that in the control group(5.13%vs 20.51%,P＜0.05).Conclusion The combination of Metoprolol and Trimetazidine has better clinical effect and can improve the blood pressure and heart function of patients with CHD and heart failure.Ⅰt has clinical application and popularization value. 2016 Vol. 23 (30): 128-130 [Abstract] ( 124 ) HTML (33 KB)  PDF  (0 KB)  ( 39 ) 131 Efficacy and safety analysis of Liraglutide in treatment of patients with type 2 diabetes mellitus and mild to moderate renal disease CHEN Zuo-ping Objective To investigate the clinical efficacy and safety of Liraglutidein in treatment of patients with type 2 diabetes mellitus(T2DM)and mild to moderate chronic kidney disease(CKD).Methods 64 patients with T2DM and mild to moderate CKD in our hospital from June 2014 to June 2015 were randomly divided into 2 groups according to the random number table method,32 cases in each group.All patients received regular treatment,and treatment group received Liraglutidein addition to the regular treatment.The treatment efficacy and safety at following up of 24 weeks between two groups were compared.Results Two patients lost in treatment group and 1 in control group at the end of following up.At 24 weeks,fasting blood glucose(FBG),hemoglobin A1c(HbA1c)and body mass index(BMⅠ)significantly decreased,and fasting insulin(FⅠNS)significantly increased than before therapy in both treatment and control group(all P＜0.05).Compared with control group,treatment group had a greater decline in FBG,HbA1c,BMⅠ,and a greater increase FⅠNS after treatment(all P＜0.05).There were no significant within-group and between-group difference of changes in estimated glomerular filtration rate,serum creatinine,systolic blood pressure,diastolic blood pressure,low-density lipoprotein,triglycerideand total cholesterol(all P＞0.05).There was no significant difference in the incidence of adverse drug reactions between the two groups(all P＞0.05).Conclusion Liraglutide can be considered as an effective and safe agent for glucose lowering and weight loss in patients with T2DM and mild to moderate CKD.However,Liraglutide has no influence on kidney function,blood pressure and blood lipid. 2016 Vol. 23 (30): 131-133 [Abstract] ( 126 ) HTML (31 KB)  PDF  (0 KB)  ( 38 ) 134 The influence of Aripiprazole on hyperprolactinemia caused by Risperidone in children and adolescent patients with schizophrenia TU Ya-ting；CHEN Hai-bo；LIANG Feng Objective To explore the effect of Aripiprazole in the treatment of hyperprolactinemia caused by Risperidone in children and adolescent schizophrenics.Methods 73 children and adolescents with schizophrenia in our hospital from October 2012 to February 2014 were divided into study group(n=37)and control group(n=36).Patients in control group continued to receive the previous therapeutic schemes,and patients in study group received Additional aripiprazole(5 mg/d)for 8 weeks.The serum prolactin(PBL)level was measured at baseline and at the end of 4thand 8thweek,and clinical symptoms and adverse reaction were assessed with the positive and negative syndrome scale(PANSS) and the treatment emergent symptom scale(TESS)at the same time.Results At the end of 4thand 8thweek,the levels of serum PRL in study group were significantly decreased than those of baseline and the levels of control group(all P＜0.05).The serum PRL level did not change during the study period in control group(all P＞0.05).Furthermore,no difference was found between the two groups in the scores of PANSS and TESS at each time point(all P＞0.05).Conclusion Aripiprazole can effectively downregulate the increased serum PRL caused by Risperidone in children and adolescent schizophrenic patients without affecting the adverse drug reaction. 2016 Vol. 23 (30): 134-136 [Abstract] ( 146 ) HTML (32 KB)  PDF  (0 KB)  ( 36 ) 137 Clinical efficacy of Mifepristone combined with Methotrexate in the treatment of placenta implantation WU Kan-ni；DANG Yu-xia Objective To investigate the clinical efficacy of Mifepristone combined with Methotrexate in the treatment of placenta implantation.Methods 58 patients with placenta implantation in our hospital from March 2012 to December 2015 were selected and randomly divided into the observation group(n=29)and the control group(n=29).The patients in the control group were treated with Methotrexate alone,and the patients in the observation group were treated with Mifepristone combined with Methotrexate.The efficacy,changes of β-HCG,progesterone and ovarian hormone,and placental discharge time before and after the treatment,blood β-HCG negative time and vaginal bleeding stop time,as well as the adverse reactions after treatment were observed.Results The effective rate was 96.55%(28/29)in the observation group and 79.31%(23/29)in the control group,and the difference was statistically significant(P＜0.05).The levels of serum β-HCG,progesterone and ovarian hormones were compared between the two groups before the treatment,with nostatistical differenc(P＞0.05).After treatment,the levels of β-HCG and progesterone of the two groups were significantly decreased,and hormone levels of LH,FSH and E2were gradually recovered(all P＜0.05).The improvement conditions in the observation group were significantly better than those in the control group(all P＜0.05).The time of placental discharge,blood β-HCG negative time and vaginal bleeding stop time were significantly lower in the observation group than those in the control group(all P＜0.05).There was no significant difference between the two groups in the incidence of myelosuppression and the incidence of adverse reactions(all P＞0.05).Conclusion Mifepristone combined with Methotrexate is more effective than Methotrexate alone in the treatment of placenta implantation.The improvement effect of sex hormones is good in early hemostasis,and no significant elevations of adverse reactions are observed. 2016 Vol. 23 (30): 137-139 [Abstract] ( 113 ) HTML (34 KB)  PDF  (0 KB)  ( 27 ) 140 Comparative study of cervical cancer screening methods CHENG Ying Objective To explore effect of the traditional pap smear cytology,liquid based cytology and human papillomavirus(HPV)application of DNA detection in the screening of patients with cervical cancer.Methods 800 patients with cervical cancer in our hospital from January 2013 to February 2016 were selected as the research object,the patients were given conventional pap smear cytology,liquid based cytology,human papillomavirus DNA screening and colposcopy in screening patients with pathological results as the final standard,the different inspection methods of the inspection results were compared.Results 800 cases of patients with pap smear screening showed that 102 cases were positive(12.8%),the results of liquid based cytology showed 112 cases were positive(14.0%)the screening method,HPV DNA positive patients showed 205 cases(25.6%),pathology screening results showed 103 cases(12.9%).The results of screening and screening results of liquid based cytology and pathology The highest consistency,which had significant difference with other two kinds of screening methods for comparison(P＜0.05).Conclusion Liquid based cytology can be used as the preferred method of screening for cervical cancer and precancerous lesions,the patients with pathological results of the highest consistency,which is worthy of clinical application. 2016 Vol. 23 (30): 140-142 [Abstract] ( 107 ) HTML (33 KB)  PDF  (0 KB)  ( 26 ) 143 Expression of serum hepatocyte growth factor in patients with hypertension and its relationship with the vascular endothelial function JIN Peng；LI Wei；LI Tao；LIU Hong-yu；YUAN Guo-liang；MA Cheng-bin Objective To investigate the expression of serum hepatocyte growth factor in patients with hypertension and its relationship with the vascular endothelial function.Methods 60 patients of hypertensive in our hospital from October 2013 to December 2014 were selected.They were divided into A group(n=21),B group(n=27)and C group(n=12)according to the level of blood pressure grade,and selected 30 cases of healthy people for physical examinees as the control group,baseline index and serum liver cell growth factor(HGF),plasma endothelin(ET)and plasma nitric oxide(NO) level of the three groups of patients were compared,and the correlation between HGF and ET and NO were analyzed. Results There were no statistical significant differences on subjects of gender,age,BMⅠ,FBG,TG etc of the groups(P＞0.05).There were significant differences on serum HGF,ET and NO levels between hypertensive patients groups and the control group(P＜0.05);HGF and ET increased with the increase of blood pressure,NO decreased with blood pressure increased,all indexes of C group had significant difference with A group and B group;HGF and NO of A group had statistical significant differences with B group(P＜0.05).Spearman correlation analysis showed that the HGF had significant positive correlation with ET(r=0.69,P＜0.05),and there was significant negative correlation between HGF and NO(r= 0.60,P＜0.05).Conclusion There is a significant correlation between the degree of HGF and blood pressure level and body impaired endothelial function levels in patients with hypertension,which can be used as a new index reflects the degree of impaired endothelial function in essential hypertension patients. 2016 Vol. 23 (30): 143-145 [Abstract] ( 126 ) HTML (33 KB)  PDF  (0 KB)  ( 32 ) 146 Clinical application discussion of Mycobacterium tuberculosis specific cellular immune response(ELISA)in hospital YANG Cheng-yun；TU Zhi-yong；DING Chao；LI Meng-jun Objective To compare the application value of specific cellular immune response to tuberculosis bacilli(A. TB detection)and Mycobacterium tuberculosis antibody in diagnosis of tuberculosis.Methods From July 2014 to December 2015,113 tuberculosis(TB)suspects who visited the infectious disease section of our hospital were recruited. During the same term,20 healthy volunteers were included as control.Of the 133 subjects,65 cases were in TB group,48 cases were in non-TB group and 20 cases were in control group.All subjects were tested by both A.TB and TB-Ab,while tuberculin skin test(TST)was performed among subjects in non-TB group and control group.Results The sensitivity and specificity of A.TB were 86.27%and 75.15%,respectively.While the sensitivity and specificity of TB-Ab were 73.91% and 59.46%,respectively.There were significant differences between those of A.TB and TB-Ab(χ2=3.941,P=0.047 and χ2= 5.268,P=0.022,respectively).Both A.TB and TB-Ab had positive correlation with TST results(r=0.280,P＜0.05 and r= 0.253,P＜0.05,respectively).Conclusion The performance sensitivity and specificity of A.TB are significantly superior to TB-Ab.According to A.TBs′test specification,A.TB is suitable for clinical application in primary hospitals at all levels. 2016 Vol. 23 (30): 146-148 [Abstract] ( 168 ) HTML (36 KB)  PDF  (0 KB)  ( 32 ) 149 Analysis of clinical distribution and drug resistance of Acinetobacter baumannii from 2013 to 2015 LIU Hong-ju；GAO Dan；GUO Jiu-ying Objective To analyze the clinical distribution and drug resistance of Acinetobacter baumannii in our hospital,and provide accurate data for clinical rational drug use.Methods 564 strains of Acinetobacter baumannii were isolated from the hospitalized patients during January 1st2013 to December 30th2015 with Siemens the MicroScan WalkA-way96 plus,an automatic bacteria identification and drug susceptibility instrument,and the computer statistical software WHONET5.6.Results There were higher detection rate in sputum,urine and secretions,84.93%,5.32%and 3.01%,respectively.Mainly distributied inⅠCU(47.87%),neurosurgical unit(16.67%),respiratory medicine wards(7.62%),and so on.Acinetobacter baumannii had the lowest resistance to SMZ-TMP(49.67%).Cefperazone-Sulbactam,imipenem,tetracycline,and levofloxacin came the next.Other medicine had higher drug resistance rate.Ⅰn addition,Acinetobacter baumannii resistance to ampicillin and cefazolin was 100.00%and 98.82%respectively.Conclusion There is a great detection rate in our hospital of Acinetobacter baumannii with a strong drug resistance rate.Ⅰt can bring a lot of trouble to clinical treatment and cause diffusible nosocomial infection most likely,which should be paid more attention for the clinicians and the infectious disease department. 2016 Vol. 23 (30): 149-151 [Abstract] ( 127 ) HTML (32 KB)  PDF  (0 KB)  ( 29 ) 152 Clinical value analysis of urine flow cytometer and microscopic detection in routine urine test LI Li；YI Min Objective To explore the clinical value of urine flow cytometer and microscopic detection in routine urine test.Methods From June 2014 to June 2015,288 patients agreed on routine urine test in our hospital were selected as research object.The urine in the early morning were collected as samples and tested by urine flow cytometer,microscopic detection,and dry chemistry accordingly.The outcomes were recorded and analyzed.Results Compared with urine flow cytometer and microscopic detection,the positive detection rates of red blood cells and white blood cells by dry chemistry were lower,which were displayed statistical differences(P＜0.05).There was no great difference in test outcomes by urine flow cytometer or microscopic detection,without a statistical difference(P＞0.05).ConclusionⅠn the process of routine urine test,applications of urine flow cytometer and microscopic detection both can have higher clinical values. Therefore,these two tests should be combined in clinical examinations in order to improve inspection levels. 2016 Vol. 23 (30): 152-154 [Abstract] ( 134 ) HTML (32 KB)  PDF  (0 KB)  ( 33 ) 155 Value of procalcitonin and CRP detection in diagnosis and treatment of premature rupture of fetal membranes and intrauterine infections RAO Dong-dong；XUE Heng；CHENG Ling；QIU Jun Objective To investigate the effectiveness of application of procalcitonin(PCT)and C-reactive protein (CRP)in the diagnosis and treatment of premature rupture of fetal membranes(PROM)and intrauterine infections. Methods Altogether 20 pregnant women who underwent cesarean delivery with premature rupture of membranes in the Department of Obstetrics in Maternity and Child Care Center of Fujian Province from January to December 2015 were taken as observation group;20 normal pregnant women who accepted cesarean section were selected as control group.3 ml of fasting venous blood were collected and detected from two groups;and pathological examinations of fetal tissuestaken after delivery of the placenta were made.Serum PCT and CRP level were measured by using nephelometry and immune chromatography method respectively.Results①Among patients in observation group,15 cases of chorioamnionitis were found and the incidence rate was 75%;while,among control group,chorioamnionitis were found in 5 cases with the incidence rate accounting for 25%.Chorioamnionitis of observation group was significantly higher than that of control group,with statistical significance(P＜0.05).②The levels of serum CRP and PCT of observation group were significantly higher than those of control group,with statistical significance(P＜0.05).There was no significant correlation between the levels of CRP and PCT in the two groups(P＞0.05).Conclusion Combination of application of serum CRP and PCT detection demonstrates high accuracyin the clinical diagnosis and treatment of premature rupture of fetal membranes and intrauterine infections,which can be used as an important indicator of the detection of chorionic villi and has great guidance significance. 2016 Vol. 23 (30): 155-157 [Abstract] ( 117 ) HTML (34 KB)  PDF  (0 KB)  ( 37 ) 158 Investigation study on the reference range of urinary sediment of the healthy population in the local area SUN Ying；ZHAO Gui-ping；SHI Mei-lin；PEI Qian-yun Objective To study and determine the reference range of urinary sediment of healthy adults in the region usingⅠQ200 urine sediment analyzer.Methods The normal urine samples from 2225 healthy subjects in our hospital from September 2013 to January 2015 were selected as the research objects,the HT-2000 urine dry chemistry analyzer and urine microscopic examination of two kinds of centrifugal method were used,white blood cells,red blood cells,the transparent tube type was detected byⅠQ200 urine sediment analyzer.The difference between 3 age groups at 21-40,41-60,more than 60 years old and the differences between different genders were compared.Percentile method was used to determine the scope of the three indicators of the reference.Results There was no significant difference in the count of red blood cells,white blood cells,the transparent tube type of different age groups of the male and female(P＞0.05).There was significant difference in the count of red blood cells,white blood cells among different age groups of the male and female(P＜0.05).There was no significant difference in the count of the transparent tube type among different age groups of the male and female(P＞0.05).ⅠQ200 urine sediment analyzer in the 95%confidence interval of the reference range was that the count of red blood cells and white blood cells in male was 0-11/μl,0-12/μl respectively; the count of red blood cells and white blood cells in female was 0-12/μl,0-19/μl respectively.The count of the transparent tube type in the male and female was 0-1/μl.Conclusion The reference range of urinary sediment established in this study is authentic,which can be used in the practical work,and can provide a reliable basis for the diagnosis and curative effect observation of clinical diseases. 2016 Vol. 23 (30): 158-160 [Abstract] ( 103 ) HTML (32 KB)  PDF  (0 KB)  ( 29 ) 161 Investigation study on risk factors of coronary heart disease in middle and old aged people in Yangjiang city ZOU Pei-yuan；CHEN Dong-lang；YANG Qing-bang Objective To understand the epidemiological features and relative risk factors of coronary heart disease (CHD)in elderly people over 50 years old in Yangjiang city,and to provide scientific theoretical basis on prevention and therapy of CHD.Methods 2000 residents(in the age more than 50 years,over 5 years of residence)from six communities of Yangjiang city from June 2015 to June 2016 were interviewed randomly,data on common CHD risk factors in the study subjects were collected by well-trained physicians.The risk factors of CHD were explored.Results A total of 2000 cases were investigated,276 CHD patients were found,morbidity rate was 13.8%.Ⅰn 1724 cases of the residents without coronary heart disease,869 cases were high-risk population of developing CHD(50.4%),542 cases were potential high risk population(31.4%),only 313 cases were healthy population(18.2%).Logistic multi-factor regression analysis indicated that there was significant difference in the correlated with age,high cholesterol,smoking,family history of CHD,hypertension,diabetes between the non CHD group and the CHD group(P＜0.01).Conclusion CHD is highly prevalent in Yangjiang city,and age,high cholesterol,smoking,family history of CHD,hypertension,diabetes are main risk factors in the elderly people in the region,prevention and modification of these risk factors should be urgently required. 2016 Vol. 23 (30): 161-163 [Abstract] ( 105 ) HTML (34 KB)  PDF  (0 KB)  ( 32 ) 164 Strengthening connotation construction and promoting the development of key discipline of urology surgery XU Hui；WANG Zhi-yong Discipline is the basic academic unit of the hospital,is the foundation of the construction and development of hospital.Construction of key discipline is an important measure to enhance the ability of scientific research and improve the quality of medical service.Strengthening the connotation construction of the hospital can significantly improve the soft power of the subject.The basis of the development of key discipline is based on full and complete connotation construction.Good department culture is conducive to strengthening the connotation construction of medical staff.Strengthening the connotation construction of the department,science and technology is the key.Construction of key discipline must take the high level talented person as the development core to orderly construct medical treatment,teaching,scientific research,management and so on key discipline content.Advanced medical equipment is the important embodiment of degree of high-tech content in modern medicine.Strengthening the connotation construction is conducive to promoting the development of key discipline in the department of urology surgery,mainly through cultural construction,technical construction,personnel construction and equipment construction to achieve.Walking the road of connotation construction,the key discipline of urology can follow the path of scientific development for sustainable and healthy development. 2016 Vol. 23 (30): 164-166转169 [Abstract] ( 94 ) HTML (33 KB)  PDF  (0 KB)  ( 32 ) 167 The importance of pharmacy management in department of pharmacy in hospital management XING Guo-liang Objective To explore the importance of pharmacy management in department of pharmacy in hospital management.Methods 30 personnels in department of pharmacy from September 2015 to March 2016 were selected as observation subject and they were analyzed retrospectively.All staff were intervened by pharmacy management in department of pharmacy.Ⅰncidence rate of irrational drug usage and dispensing error before and after intervention was compared.Results After intervention,the incidence rate of irrational drug usage and dispensing error was(6.67%and 3.33% respectively)was obviously lower than that of before intervention(40.00%,23.33%)(P＜0.05).ConclusionⅠn the work of hospital management,department of pharmacy given the intervention of pharmacy management can effectively improve the phenomenon of irrational drug usage,reduce the incidence rate of dispensing error.Ⅰt can be promoted and applied. 2016 Vol. 23 (30): 167-169 [Abstract] ( 117 ) HTML (32 KB)  PDF  (0 KB)  ( 32 ) 170 Rresearch of application value of fine management in the prevention of nosocomial infection in the interventional operation room LI Yi；ZHONG Wen；ZHU Ling-juan；ZHANG Qian；XU Mei-zhen；WU Yan-qing Objective To explore the application effect of fine management in the prevention of nosocomial infection in the interventional operation room.Methods From June to December 2015,fine management was conducted in the interventional operation room of our hospital.Hospital infection prevention and control group was established according to practical work of operation room and work characteristics in our hospital.Fine management was conducted in view of personnel,goods,environment and so on of interventional operation room,fine management was applied to indoor air disinfection,hand disinfection and other work standards.Ⅰndoor disinfection,air quality,pollutant treatment and incision infection rate and other indicators before and after fine management in the interventional operation room of pour hospital was given statistical comparison.Results After the implement of fine management,qualified rate of disinfection behavior(95.0%),qualification rate of disposal of pollutants(92.9%)was obviously improved compared with before fine management(76.8%,61.5%)in interventional operation room of our hospital(P＜0.05).At the same time,the rate of incision infection(0.7%)was obviously decreased compared with before fine management(6.8%)(P＜0.05).There was no significant difference of qualified rate of air quality between before the implementation of fine management(95.8%)and after the implementation of fine management(100.0%)in interventional operation room of our hospital(P＞0.05).Conclusion The fine management has a good effect in the prevention of nosocomial infection in the interventional operation room, and it can significantly improve the qualified rate of disinfection behavior and disposal of pollutants,and reduce the the rate of incision infection in patients.Ⅰt is worthy of clinical application. 2016 Vol. 23 (30): 170-172 [Abstract] ( 130 ) HTML (30 KB)  PDF  (0 KB)  ( 35 ) 173 Practice and effect of"angel service"rating activity to promote the longterm effective mechanism of high quality nursing SHENG Chuan-ling；XIE Wei；JIANG Qun；HUANG Hong-juan Objective To explore the effective way to establish a long-term effective mechanism of high quality nursing service.Methods"Angel service"rating activity was conducted in all 31 nursing units carrying out"high quality nursing service"in our hospital in May 2015.By using their own historical control method,they were divided into control group and test group.Nursing quality,the correct implementation of nursing service standard and satisfaction degree of patients to job of nursing staff before and after activity was given statistical analysis.Results Compared with control group,the nursing quality,the rate of the correct implementation of nursing service standard and the satisfaction degree of patients to job of nursing staff were significantly improved,and the difference was statistically significant(P＜0.05). Conclusion"Angel service"rating activity can promote the long-term effective mechanism of high quality nursing. 2016 Vol. 23 (30): 173-175 [Abstract] ( 134 ) HTML (33 KB)  PDF  (0 KB)  ( 38 ) 176 The influence of children′s immunization leak replant measures on improving immunization vaccination rate ZHANG Fei-fei；HUANG Hui-zhen；ZHANG Yan-ping Objective To study and explore the influence of children′s immunization leak replant measures on improving immunization vaccination rate.Methods From January to December 2015,0 to 14 years old immigrated children in Shenzhen Songgang street were selected as the object of study,a total of 306 cases of children were set as the observation group,and the children were implemented a model of planned immunization leak replanting measures including the health departments,hospitals,housing leasing tripartite cooperation leak replanting measures.From January to December 2014,298 cases of 0-14 years old immigrated children in Shenzhen Songgang street were selected and set as the control group,the group implemented conventional leak replanting measures.The building permits rate,cards rate and vaccination rate were compared between two groups.Results The building permit rate,cards rate of the observation group was 99.67%,98.37%,compared with 84.23%,82.55%of the control group,which was significantly higher(P＜0.05).The vaccination rate of BCG,hepatitis B vaccine,measles vaccine,poliomyelitis vaccine,the 100 day break,Japanese encephalitis vaccine between two groups in the observation group was significantly higher,and the difference had statistical significance(P＜0.05).ConclusionⅠn immigrated children taken health departments,hospitals,housing leasing tripartite cooperation program on immunization of leak replanting measures,can effectively improve the rate of childhood immunization schedule,helps to reduce the spread of infectious diseases in the pediatric population. 2016 Vol. 23 (30): 176-178 [Abstract] ( 135 ) HTML (33 KB)  PDF  (0 KB)  ( 33 ) 179 The molecular evolution analyzing of hemagglutinin and neuraminidase gene for H7N9 avian influenza virus in our country LIU Da-wei Objective To explore molecular evolution analyzing of hemagglutinin and neuraminidase gene for H7N9 avian influenza virus in our country.Methods The medical records of human infection H7N9 avian influenza virus for different ways publishing,the epidemiology feature for H7N9 avian influenza virus in our country from January 2013 to November 2015 were analyzed,the nucleotide sequence and amino acid sequence of H7N9 avian influenza virus viral strain were selected,nucleotide and coding key sites were analyzed.Results Homologous points of viral strain inland were greater than 0.99,from neuraminidase gene were homology analyzed,neuraminidase gene KF662949 of the first H7N9 avian influenza virus in Guangdong and neuraminidase gene CY147110 of avian influenza virus in Shandong, neuraminidase gene KF500926 of avian influenza virus in Zhejiang were higher homology,KF662949 and CY147110 homology score was 0.999.Amino acid sequence cracking site and potential glycosylation sites of hemagglutinin was 30,46,249,421,493,Amino acid sequence resistance loci and potential glycosylation sites of neuraminidase was 119R, 120E,152D,153R,200N,226R,229E,245D,276H,278E,279E,294R,332D,351K,427E.Conclusion H7N9 avian influenza virus has a certain aggregation in time and space,with closer time,shorter distance,which has appeared more close evolutionary relationship. 2016 Vol. 23 (30): 179-182 [Abstract] ( 126 ) HTML (32 KB)  PDF  (0 KB)  ( 27 ) 183 Study on enteropathy-associated T-cell lymphoma leading to intestinal perforation in one case MENG Xiang-rui；SONG Ning-ning；DING Yin-lu Enteropathy-associated T-cell lymphoma(EATL)is an extra-nodal maligant T-cell lymphoma originated from intestinal.Patients with EATL in Asia are mostly typeⅡ.Ⅰts main clinical manifestations are abdominal pain,fever and weight loss and its most common complication is intestinal perforation.Ⅰn clinical,EATL is hardly differentiate from Crohn′s disease and intestinal tuberculosis.This article represented a patient with EATL was treated in the Second Hospital of Shandong University.After reviewed the related literature,the clinical manifestations,pathological features,differential diagnosis and prognosis of EATL were discussed. 2016 Vol. 23 (30): 183-185 [Abstract] ( 125 ) HTML (31 KB)  PDF  (0 KB)  ( 37 ) 186 Nursing intervention on emergency and severe maternal pre-hospital care and mental pain PEI Jing-hong；XI Chun-yu；QIU Yan-fei Objective To explore the impact of emergency and severe maternal pre-hospital care and mental pain of nursing intervention.Methods 120 cases of emergency and severe maternal patients from June 2015 to June 2016 in Medical Emergency Rescue Center of Jingdezhen City were selected,and were randomly divided into control group and intervention group,the control group was given routine care,the intervention group intervention patients were given before administering emergency care hospital system on the basis of conventional nursing.After the patients with psychological first aid and pain relief scores of two groups were compared.Results After treatment,SAS and SDS scores of two groups were improved significantly(P＜0.05)compared to pre-intervention,and the SAS and SDS scores of intervention group were higher than that of control group,the differences were significant(P＜0.05).the pain relieving degree of intervention group was significantly better than that of control group,the difference was significant(P＜0.05).Conclusion Severe maternal emergency aid the implementation of standardized pre-hospital emergency care so that patients can get the first time an effective aid,better aid,can significantly ease the pain of the patient and improve mental state. 2016 Vol. 23 (30): 186-188 [Abstract] ( 113 ) HTML (32 KB)  PDF  (0 KB)  ( 31 ) 189 Effect of individualized nursing intervention on the prevention of reactive power of arteriovenous fistula in hemodialysis patients XU Tao-ying Objective To explore the effect of individualized nursing intervention on the prevention of reactive power of arteriovenous fistula in hemodialysis patients.Methods 80 patients with hemodialysis from February 2015 to February 2016 in our hospital were selected.They were divided randomly into observation group and control group,each of the 40 cases.The control group was given routine nursing care,the observation group was given personalized nursing,complication rate,quality of life and satisfaction degree of nursing were compared.Results After nursing,the total incidence of observation group was obviouly lower than that of control group(P＜0.05）;the health index,the emotional index,the psychological index scores of observation group were higher than that of control group(P＜0.01);After nursing,nursing satisfaction and comfort level of observation group were higher than that of control group(P＜0.01);Conclusion Effective individualized nursing intervention in hemodialysis patients,can effectively prevent the loss of reactive power of arteriovenous fistula,improve the quality of life,it is worthy of application and promotion. 2016 Vol. 23 (30): 189-191 [Abstract] ( 135 ) HTML (32 KB)  PDF  (0 KB)  ( 32 ) 192 High quality nursing intervention in patients with chronic renal failure peritoneal dialysis YANG Shui-feng Objective To explore the effect of high quality nursing intervention on patients with chronic renal failure peritoneal dialysis.Methods 88 cases of continuous ambulatory peritoneal dialysis patients in our hospital from January to December 2015 were Selected,and randomly divided into two groups,44 cases in each group.The observation group was used the high quality nursing intervention,and the control group was used routine nursing.Ⅰncidence of peritonitis between the two groups,including the patient′s physical function,psychological function,social function and material life, quality of life were compared.Results The peritonitis rate of observation group was 9.1%,which was significantly lower than that of control group(15.9)%.The physical function,psychological function,social function and material life,the total score of quality of life respectively of observation group were(65±7),(82±8),(81±9),(76±7),(73±8)scores,which was significantly higher than that of control group(49±6),(7±9),(63±8),(63±10),(61±7)scores,the differences were significant (P＜0.05).Conclusion Quality care interventions used in peritoneal dialysis chronic renal failure,not only can effectively reduce the incidence of peritonitis,while improving the quality of life of patients,it should be promoted. 2016 Vol. 23 (30): 192-194 [Abstract] ( 98 ) HTML (33 KB)  PDF  (0 KB)  ( 35 )

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