米非司酮联合甲氨蝶呤治疗胎盘植入的临床效果

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Abstract Objective To investigate the clinical efficacy of Mifepristone combined with Methotrexate in the treatment of placenta implantation.Methods 58 patients with placenta implantation in our hospital from March 2012 to December 2015 were selected and randomly divided into the observation group(n=29)and the control group(n=29).The patients in the control group were treated with Methotrexate alone,and the patients in the observation group were treated with Mifepristone combined with Methotrexate.The efficacy,changes of β-HCG,progesterone and ovarian hormone,and placental discharge time before and after the treatment,blood β-HCG negative time and vaginal bleeding stop time,as well as the adverse reactions after treatment were observed.Results The effective rate was 96.55%(28/29)in the observation group and 79.31%(23/29)in the control group,and the difference was statistically significant(P＜0.05).The levels of serum β-HCG,progesterone and ovarian hormones were compared between the two groups before the treatment,with nostatistical differenc(P＞0.05).After treatment,the levels of β-HCG and progesterone of the two groups were significantly decreased,and hormone levels of LH,FSH and E2were gradually recovered(all P＜0.05).The improvement conditions in the observation group were significantly better than those in the control group(all P＜0.05).The time of placental discharge,blood β-HCG negative time and vaginal bleeding stop time were significantly lower in the observation group than those in the control group(all P＜0.05).There was no significant difference between the two groups in the incidence of myelosuppression and the incidence of adverse reactions(all P＞0.05).Conclusion Mifepristone combined with Methotrexate is more effective than Methotrexate alone in the treatment of placenta implantation.The improvement effect of sex hormones is good in early hemostasis,and no significant elevations of adverse reactions are observed.

Key words： Mifepristone Methotrexate Placenta implantation Safety

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	WU Kan-ni
	DANG Yu-xia

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WU Kan-ni,DANG Yu-xia. Clinical efficacy of Mifepristone combined with Methotrexate in the treatment of placenta implantation[J]. 中国当代医药, 2016, 23(30): 137-139.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2016/V23/I30/137

	[参考文献]
[1]	俞泓，周紫琼.完全性、部分、边缘性前置胎盘与妊娠结局的关系研究[J].中国当代医药，2015，22（6）：78-80.
[2]	耿力，肖虹，肖李乐云，等.凶险性前置胎盘合并胎盘植入40例临床分析[J].现代妇产科进展，2016，25（4）：292-295.
[3]	徐飞顶.米非司酮联合甲氨蝶呤治疗异位妊娠的临床效果观察[J].中国当代医药，2014，21（10）：73-74.
[4]	蒲玲珍.米非司酮治疗胎盘粘连及胎盘植入疗效观察[J].中国现代药物应用，2016，10（3）：188-189.
[5]	中华医学会围产医学分会，中华医学会妇产科学分会产科学组.胎盘植入诊治指南（2015）[J].中华妇产科杂志，2015，50（12）：970-972.
[6]	李艳丽.米非司酮联合甲氨蝶呤治疗异位妊娠的疗效观察[J].中国当代医药，2013，20（5）：83-84.
[7]	杨素芳.米非司酮治疗胎盘植入的临床观察[J].实用临床医学，2013，14（10）：74，82.
[8]	赵金华，郭玉华，葛娜.前置胎盘合并胎盘植入的临床诊治分析[J].中国妇幼保健，2013，28（24）：3935-3937.
[9]	严小丽，陈诚，常青，等.凶险性前置胎盘20例临床分析[J].实用妇产科杂志，2013，29（9）：704-707.
[10]	陈功泉，石琳.超声引导下甲氨蝶呤局部注射保守治疗胎盘植入的意义[J].中国妇幼保健，2015，30（6）：968-969.
[11]	王卫珍.米非司酮联合甲氨蝶呤治疗胎盘植入的临床疗效观察[J].中国实用医药，2016，11（22）：135-136.
[12]	马壮，蔡舒，宁华丽，等.大剂量甲氨蝶呤子宫动脉灌注栓塞术治疗胎盘植入产后出血56例分析[J].中华妇幼临床医学杂志（电子版），2013，9（4）：439-442.
[13]	温彩霞，陈笙生，黄彩秀.米非司酮治疗产后胎盘植入的疗效观察[J].中国现代药物应用，2013，7（12）：167-168.
[14]	吴芸，孟敬一，曲晓丽.米非司酮在胎盘粘连或植入治疗中的应用[J].实用医药杂志，2013，30（8）：706-707.
[15]	时黔宇.甲氨蝶呤、米非司酮联合益母调经合剂治疗胎盘粘连植入的疗效[J].中国现代医学杂志，2015，25（28）：106-109.
[16]	黄月琴，肖蔚.甲氨喋呤联合米非司酮及生化汤治疗胎盘植入[J].当代医学，2011，17（2）：39.