阿立哌唑对利培酮所致儿童和青少年精神分裂症患者高催乳素血症的影响

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Abstract Objective To explore the effect of Aripiprazole in the treatment of hyperprolactinemia caused by Risperidone in children and adolescent schizophrenics.Methods 73 children and adolescents with schizophrenia in our hospital from October 2012 to February 2014 were divided into study group(n=37)and control group(n=36).Patients in control group continued to receive the previous therapeutic schemes,and patients in study group received Additional aripiprazole(5 mg/d)for 8 weeks.The serum prolactin(PBL)level was measured at baseline and at the end of 4thand 8thweek,and clinical symptoms and adverse reaction were assessed with the positive and negative syndrome scale(PANSS) and the treatment emergent symptom scale(TESS)at the same time.Results At the end of 4thand 8thweek,the levels of serum PRL in study group were significantly decreased than those of baseline and the levels of control group(all P＜0.05).The serum PRL level did not change during the study period in control group(all P＞0.05).Furthermore,no difference was found between the two groups in the scores of PANSS and TESS at each time point(all P＞0.05).Conclusion Aripiprazole can effectively downregulate the increased serum PRL caused by Risperidone in children and adolescent schizophrenic patients without affecting the adverse drug reaction.

Key words： Schizophrenia Children and adolescents Aripiprazole Risperidone Prolactin

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	TU Ya-ting
	CHEN Hai-bo
	LIANG Feng

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TU Ya-ting,CHEN Hai-bo,LIANG Feng. The influence of Aripiprazole on hyperprolactinemia caused by Risperidone in children and adolescent patients with schizophrenia[J]. 中国当代医药, 2016, 23(30): 134-136.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2016/V23/I30/134

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