高血压患者血清肝细胞生长因子的表达及与血管内皮功能的关系

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Abstract Objective To investigate the expression of serum hepatocyte growth factor in patients with hypertension and its relationship with the vascular endothelial function.Methods 60 patients of hypertensive in our hospital from October 2013 to December 2014 were selected.They were divided into A group(n=21),B group(n=27)and C group(n=12)according to the level of blood pressure grade,and selected 30 cases of healthy people for physical examinees as the control group,baseline index and serum liver cell growth factor(HGF),plasma endothelin(ET)and plasma nitric oxide(NO) level of the three groups of patients were compared,and the correlation between HGF and ET and NO were analyzed. Results There were no statistical significant differences on subjects of gender,age,BMⅠ,FBG,TG etc of the groups(P＞0.05).There were significant differences on serum HGF,ET and NO levels between hypertensive patients groups and the control group(P＜0.05);HGF and ET increased with the increase of blood pressure,NO decreased with blood pressure increased,all indexes of C group had significant difference with A group and B group;HGF and NO of A group had statistical significant differences with B group(P＜0.05).Spearman correlation analysis showed that the HGF had significant positive correlation with ET(r=0.69,P＜0.05),and there was significant negative correlation between HGF and NO(r= 0.60,P＜0.05).Conclusion There is a significant correlation between the degree of HGF and blood pressure level and body impaired endothelial function levels in patients with hypertension,which can be used as a new index reflects the degree of impaired endothelial function in essential hypertension patients.

Key words： Hypertension Hepatocyte growth factor Vascular endothelial function Nitric oxide Endothelin

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	Articles by authors
	JIN Peng
	LI Wei
	LI Tao
	LIU Hong-yu
	YUAN Guo-liang
	MA Cheng-bin

Cite this article:

JIN Peng,LI Wei,LI Tao, et al. Expression of serum hepatocyte growth factor in patients with hypertension and its relationship with the vascular endothelial function[J]. 中国当代医药, 2016, 23(30): 143-145.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2016/V23/I30/143

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