小儿喘息性支气管炎应用孟鲁司特钠治疗的价值分析

Abstract
Figure/Table
References (21)
Related Citation (15)

Download: PDF (0 KB) HTML (34 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To explore the clinical effect of Montelukast Sodium in the treatment of pediatric asthmatic bronchitis.Methods 100 cases of pediatric asthmatic bronchitis in our hospital from January 2012 to December 2015 were selected and divided into the control group and the observation group according to the random number table method,50 cases in each group.The control group was given routine symptomatic treatment,the observation group was given Montelukast Sodium on the basis of the routine symptomatic treatment for 4 weeks.The clinical total effective rate,disappeared time of cough,wheeze disappeared time,wheezing disappearance time,hospitalization time and inflammatory markers were compared between the two groups.Results The total effective rate in the observation group was 96%, which was higher than 80%in the control group,with significant difference(P＜0.05).The cough disappeared time,wheezing rale disappearance time,wheezing disappearance time,hospitalization time in the observation group was shorter than that in the control group,with significant difference(P＜0.01).The level of C reactive protein and white blood cell count after treatment in the two groups was lower than that before treatment,with significant difference(P＜0.01).The level of C reactive protein and white blood cell count after treatment in the observation group was lower than that in the control group after treatment,with significant difference(P＜0.01).Conclusion The using of Montelukast Sodium in the treatment of pediatric asthmatic bronchitis has remarkable clinical curative effect,which can effectively alleviate the patient′s clinical symptoms,restrain the airway inflammation.

Key words： Paediatrics Asthmatic bronchitis Montelukast Sodium C reactive protein

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	ZHENG Ya-wen
	CUI Zhi-liang
	CHENG Ka-mi
	ZHU Yue-e
	TANG Liang

Cite this article:

ZHENG Ya-wen,CUI Zhi-liang,CHENG Ka-mi, et al. Evaluation of the value about the treatment of Montelukast Sodium in children with asthmatic bronchitis[J]. 中国当代医药, 2016, 23(30): 91-93.

URL:

http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2016/V23/I30/91

[1]	申玉，韩雄信，李若飞，等.孟鲁司特钠咀嚼片联合多索茶碱治疗喘息性支气管炎68例[J].中国药业，2015，24（5）：60-62.
[2]	Bozek A，Warkocka-Szoltysek B，Filipowska-Gronska A，et al.Montelukast as an add-on therapy to inhaled corticosteroids in the treatment of severe asthma in elderly patients[J].J Asthma，2012，49（5）：530-534.
[3]	严炜.孟鲁司特钠联合干扰素α1b治疗小儿喘息性支气管炎的临床疗效[J].中华妇幼临床医学杂志（电子版），2015，9（5）：605-608.
[4]	朱克华.孟鲁司特钠治疗小儿喘息性支气管炎32例的临床疗效观察[J].中国民族民间医药，2013，22（17）：65-65.
[5]	吴先海，罗锦涛，何珊，等.孟鲁司特钠治疗小儿喘息性支气管炎64例临床分析[J].中国民康医学，2013，25（1）：49-50.
[6]	李华芳.孟鲁司特钠联合氨溴特罗治疗小儿喘息性支气管炎临床疗效观察[J].现代诊断与治疗，2013，23（20）：4610-4611.
[7]	周长华.喘息性支气管炎稳定期患儿口服孟鲁司特钠预防喘息及哮喘发作的随访评价[J].河北医药，2015，37（9）：1348-1350.
[8]	Scaife A，Miller D，Spiteri-Cornish D，et al.Ⅰnhibitory effects of Montelukast on mediator release by nasal epithelial cells from asthmatic subjects with or without allergic rhinitis[J]. Respir Med，2013，107（12）：1859-1865.
[9]	陈新宙，黄荷，易飞，等.孟鲁司特钠联合小剂量阿奇霉素治疗小儿喘息性支气管炎临床观察[J].医学信息，2013，26（22）：87-88.
[10]	罗思华，唐渊，陈练，等.孟鲁司特钠治疗小儿喘息性支气管炎的临床分析[J].中外医疗，2014，34（27）：155-156.
[11]	刘金联.应用孟鲁司特钠治疗小儿喘息性支气管炎的临床研究[J].中国继续医学教育，2015，7（6）：210-211.
[12]	刘华容.布地奈德、硫酸特布他林、异丙托溴铵气雾剂联合雾化吸入治疗小儿喘息性支气管炎的效果观察[J].中国医药导报，2014，11（1）：76-78，82.
[13]	Cai C，He MZ，Zhong SQ，et al.Add-on montelukast vs double-dose budesonide in nonasthmatic eosinophilic bron chitis：a pilot study[J].Respir Med，2012，106（10）：1369-1375.
[14]	高祥.孟鲁司特钠治疗小儿喘息性支气管炎疗效评价[J].医学信息，2014，27（24）：513-514.
[15]	丁忠莲.孟鲁司特钠治疗小儿喘息性支气管炎的临床观察[J].中外女性健康，2014，6（4）：66，111.
[16]	张丽红，钟远辉.孟鲁司特钠治疗小儿喘息性支气管炎的疗效分析[J].当代医学，2015，21（12）：135-136.
[17]	张钦刚.孟鲁司特联合舒利迭治疗支气管哮喘的临床研究[J].中国医药科学，2016，6（5）：112-114.
[18]	秦微，施文叠，易仟仞，等.孟鲁司特钠治疗小儿变异性哮喘的临床疗效探讨[J].中国医药科学，2014，4（15）：135-137.
[19]	王斌，吴静华，李永权，等.孟鲁司特钠治疗小儿喘息性支气管炎的疗效及对气道高反应性的预防效果分析[J].医学综述，2016，22（8）：1600-1602.
[20]	AhmedS，AtiaNN.Simultaneousdeterminationofmontelukast as sparing therapy with some inhaled corticosteroids in plasma of asthmatic patients[J].J Pharm Biomed Anal，2013，74：250-256.
[21]	何炜，谢忠罗，黄正国，等.孟鲁司特钠联合布地奈德预防毛细支气管炎反复喘息的疗效观察[J].中国初级卫生保健，2013，27（2）：99-100.