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Quick Search     Adv Search 2022 Vol. 29, No. 13 Published: 2022-05-08   5 Mitochondrial proteomic of genistein protection against oxidative damage in human lens epithelial cells FENG Chunyan； TANG Songwen； HUANG Xiurong； QI Mingxin； HU Yanhong  Objective To investigate the protective effect of the natural medicinal monomer genistein (GEN) with estrogenic activity against oxidative damage in human lens epithelial cells B3 (HLE-B3) caused by hydrogen peroxide (H2O2) and to pursue the possible mitochondrial proteomic regularity of the protective effect. Methods HLE-B3 were divided into four groups: normal group, H2O2 group, estradiol (E2) group and GEN group. Normal group is normal culture HLE-B3, H2O2 group with final concentration of 300 μmol/L H2O2, E2 group with final concentration of 300 μmol/L H2O2 and 10-8 mol/L E2, the final concentration of 300 μmol/L H2O2 and 10-6 mol/L GEN were added into the GEN group. The mitochondrial protein expression profiles of HLE-B3 in each group were detected by surface enhanced laser desorption ionization time of flight mass spectrometry (SELDI-TOF-MS) combined with protein chip technology, and the differential proteins were analyzed. Results Two differentially expressed protein sites with mass to charge ratios of 6532 and 6809 appeared after oxidative damage of HLE-B3 induced by H2O2. The peak value of H2O2 group was higher than that of normal group, the difference was statistically significant (P<0.05). The peak value of protein point in E2 group with mass/charge ratio of 6532 was lower than that in H2O2 group, the difference was statistically significant (P<0.05). The peak values of protein points 6532 and 6809 in GEN group were lower than those in H2O2 group, the differences were statistically significant (P<0.05). Conclusion GEN could effectively inhibite H2O2 induced oxidative damage in HLE-B3 cells. The protein spot at mass/charge ratio of 6532 might be the target spot of GEN against oxidative damage induced by H2O2. Mitochondrial RPS29 may be a mitochondrial protein that protects epithelial cell from oxidative damage by phytoestrogens GEN. In order to provide scientific basis for pursueing safe and effective natural drugs to prevent and cure senile cataract. 2022 Vol. 29 (13): 5-9 [Abstract] ( 31 ) HTML (1 KB)  PDF (888 KB)  ( 71 ) 10 Effect of tetrahydroxystilbene glucoside on the expression of Nalp3,Caspse-1, interleukin-18 in rats with cerebral ischemia-reperfusion injury CHEN Xue1 ZHANG Yuanyi1 DUAN Wenbiao Objective To explore the effect of tetrahydroxystilbene glucoside(TSG)on the expression of Nalp3,Caspse-1,interleukin-18 (IL-18) in rats with cerebral ischemia-reperfusion injury. Methods Sixty SD rats were randomly divided into five groups, namely sham operation group, model group, TSG low-dose group, TSG medium-dose group, TSG highdose group, with 12 rats in each group. The bilateral common carotid arteries were clamped for 2 h, and the arterial clamps were removed to restore blood perfusion to prepare the animal model of cerebral ischemia-reperfusion injury.The sham operation group was anesthetized and bilateral common carotid arteries were separated without clamping. TSG low, medium and high dose groups were given TSG 30, 60, 90 mg/kg, intraperitoneal injection once a day for 7 consecutive days. The sham operation group and model group were given the same dose of normal saline. On the 8th day after the operation, the rats were anesthetized, and the related specimens were reserved. The histomorphological changes of HE staining hippocampus were observed by light microscope. The brain water content of rats in each group was calculated by dry and wet weight method. The expressions of Nalp3 mRNA, Caspase-1 mRNA and IL-18 mRNA in hippocampus were detected by RT-PCR. Results HE staining showed that the hippocampal nerve cells in the model group were seriously damaged. The damage of hippocampal nerve cells in TSG medium and high dose group were significantly reduced. The brain water content of rats in the model group and the expressions of Nalp3 mRNA,Caspase-1 mRNA and IL-18 mRNA in the hippocampus were higher than those in the sham operation group, and the differences were statistically significant (P＜0.05). The brain water content and the expressions of Nalp3 mRNA,Caspase-1 mRNA and IL-18 mRNA in the hippocampus of rats in the middle and high-dose TSG groups were lower than those in the model group, and the differences were statistically significant (P＜0.05). Conclusion TSG can inhibit the expression of Nalp3, Caspse-1, and IL-18 in the hippocampus of rats with cerebral ischemia-reperfusion injury, reduce the inflammation cascade, and have a protective effect on nerve cells. 2022 Vol. 29 (13): 10-13转19 [Abstract] ( 33 ) HTML (1 KB)  PDF (604 KB)  ( 82 ) 14 Analysis of the medication rule of health food prescription with hypolipidemic function based on data mining method LIU Jing SHENG Kai GUAN Feng LUAN Ning WANG Rong WANG Yanhong Objective Based on data mining method, this paper discusses the medication rule of health food prescription with hypolipidemic function. Methods Taking the compound health food for reducing blood lipid collected by state administration for market regulationas the data source, Microsoft Excel 2019 was used to analyze the data in terms of dosage form, health care function, efficacy classification and medication frequency. Describe the nature, taste and meridian tropism of high-frequency Chinese medicine (frequency ≥15). SPSS Statistic 20.0 and SPSS Modeler 15.0 were used to analyze the systematic clustering and association rules of high-frequency traditional Chinese medicine.Results A total of 343 prescriptions met the requirements, among which the capsule (260 prescriptions) accounted for 75.80%. The number of health foods with one and two health functions was 251 and 92, respectively. A total of 103 traditional Chinese medicines, such as tonifying deficiency, antitussive antiasthmatic, relieving exterior syndrome and promoting blood circulation and removing blood stasis were used frequently. There were 15 kinds of high-frequency traditional Chinese medicines, which were mainly sweet, mostly mild and cold, and mainly belong to liver, spleen and lung meridians. Eight drug combinations were obtained by further cluster analysis, and the association rule analysis showed that Gynostemma pentaphyllum, Pueraria lobata, Salvia miltiorrhiza, Ginkgo biloba and Hawthorn were highly correlated. Conclusion The formula of health food with the function of lowering blood lipids is mainly composed of tonifying deficiency and invigorating spleen to treat its origin, promoting blood circulation, invigorating dampness and resolving phlegm to treat its standard. It is basically consistent with the theory of reducing blood lipids of traditional Chinese medicine, that is, strengthening body resistance, eliminating phlegm, removing blood stasis and removing dampness. 2022 Vol. 29 (13): 14-19 [Abstract] ( 37 ) HTML (1 KB)  PDF (951 KB)  ( 57 ) 20 Clinical effect of Butylphthalide Soft Capsules in the treatment of acute ischemic stroke and its influence on the neutrophil to lymphocyte ratio and interleukin-33 WU Xiaowei XIAO Yan Objective To investigate the curative effect of Butylphthalide Soft Capsules in the treatment of acute ischemic stroke and its influence on neutrophil to lymphocyte ratio (NLR) and interleukin-33 (IL-33). Methods A total of 130 patients with acute ischemic stroke admitted to the Department of Neurology of the 73rd Army Hospital of the Army from July 1,2020 to June 30,2021 were selected as the study subjects.They were divided into study group(65 cases) and control group (65 cases) by random number table method. The control group was given conventional treatment,and the study group was combined with Butylphthalide Soft Capsules. The improvement of neurological impairment and the ability of daily living were compared between the two groups before and after treatment, and the levels of neutrophil(N), lymphocyte (L), NLR and IL-33 were compared between the two groups before and after treatment. Results After treatment, the scores of National Institutes of Health stroke scale (NIHSS) in the two groups were lower than those before treatment, the Barthel indexes in the two groups were higher than those before treatment, and the NIHSS score in study group was lower than that in the control group, the Barthel index in study group was higher than that in the control group (P<0.05). After treatment, N and NLR levels in the two groups were lower than those before treatment, while L levels in the two groups were higher than those before treatment, and N and NLR levels in study group were lower than those in the control group, while L level in study group was higher than that in the control group (P<0.05). After treatment, the levels of IL-33 in the two groups were higher than those before treatment, and the level of IL-33 in study group was higher than that in the control group (P<0.05). Conclusion Butylphthalide Soft Capsules has a significant clinical effect on patients with acute ischemic stroke, which can reduce NLR and increase IL-33 level, and has a positive effect on improving the prognosis of patients, which is worthy of promotion. 2022 Vol. 29 (13): 20-23 [Abstract] ( 34 ) HTML (1 KB)  PDF (579 KB)  ( 89 ) 24 Research progress of traditional Chinese exercises therapy in chronic obstructive pulmonary disease and its comorbidities YE Shuai；XIE Xiaohong； XIAO Wei Chronic obstructive pulmonary disease(COPD)is a chronic lung disease characterized by persistent respiratory symptoms and limited airflow with high incidence and mortality rate. It often coexists with cardiovascular disease, lung cancer and other diseases, which is called COPD comorbidity. Comorbidity has an important impact on the progression of COPD,but clinicians still pay less attention to comorbidity.Traditional Chinese exercises include Taijiquan,Baduanjin,Wuqinxi, Yijinjing and Guixinggongfa. After continuous practice and improvement by clinicians, they have been widely used as exercise prescriptions in COPD and its common comorbidities. As a non drug therapy. As a non-drug therapy,traditional Chinese exercises meets the requirements of simplified drug therapy recommended by the guidelines, and has considerable practicability, effectiveness and economical. This paper aims to summarize the latest research on the intervention of traditional Chinese exercise in COPD and its common comorbidities in recent 3 years, provide new ideas for the rehabilitation treatment, explore some deficiencies in the current clinical trial and application of traditional Chinese exercise, and provide reference for the in-depth study of the mechanism of traditional Chinese exercises. 2022 Vol. 29 (13): 24-27 [Abstract] ( 33 ) HTML (1 KB)  PDF (432 KB)  ( 42 ) 28 Research progress of postoperative quality of life intervention in patients with lung cancer CUI Yanwei CHEN Guangmei CHEN Xiaoyun Because of the factors such as smoking,air pollution and heredity,the incidence rate and mortality rate of lung cancer increased gradually every year. With the widespread application of low dose spiral CT screening, more early lung cancer patients have been found, and surgical resection was considered to be the effective means for the treatment of lung cancer. As one of the evaluation criteria of treatment effect, postoperative quality recovery of life has been paid more and more attention. Therefore, for postoperative patients with lung cancer, it is an important problem for clinicians to pay attention to of postoperative patients, improve the quality of life of postoperative patients, and eliminate the adverse factors affecting the quality of life of postoperative patients as soon as possible through intervention. As a clinician, by improving personal humanistic cultivation and professional quality, further improve the postoperative management and education system of lung cancer patients, and use the correct philosophical concept and logical way to deal with the clinical problems related to the postoperative quality of life of lung cancer patients. The adverse emotion, physiological function，psychological and social or economic burden of the postoperative lung cancerpatients can be eased. 2022 Vol. 29 (13): 28-31 [Abstract] ( 29 ) HTML (1 KB)  PDF (428 KB)  ( 108 ) 32 Application effect of bispectral index combined with Richmond agitationsedation score in the sedation evaluation of patients with mechanical ventilation XIONG Yu1 WANG Jin1 PENG Meina2 PENG Binfei1 LI Jianzhi1 LIU Juan1 WAN Xinwen1 Objective To investigate the application effect of bispectral index (BIS) combined with Richmond agitationsedation scale (RASS) in the sedation evaluation of patients with mechanical ventilation. Methods A total of 60 patients with mechanical ventilation in the Emergency Intensive Care Unit (EICU) of Nanchang First Hospital from December 2019 to June 2020 were divided into control group (n=30) and experimental group (n=30) by the random number table method. The control group was treated only with routine sedation therapy, and the experimental group was treated with BIS combined with RASS score to guide sedation therapy. The treatment time of EICU, the total use of sedatives, the time of mechanical ventilation, the adverse reactions during the diagnosis and treatment of EICU and the total hospital stay were compared between the two groups. Results The duration of EICU stay and mechanical ventilation in experimental group was shorter than that in control group, and the total incidence of adverse events was lower than that in control group, with statistical significances (P<0.05). There was no significant difference in total hospital stay between the two groups (P>0.05). The total amount of Midazolam in experimental group was less than that in control group, the difference was statistically significant (P<0.05). There was no significant difference in the total amount of dexmedetomidine between the two groups (P>0.05). Conclusion Sedation therapy guided by RASS score combined with BIS can significantly shorten the time of mechanical ventilation, the time of EICU treatment, reduce the dose of sedatives and the total incidence of adverse events, which is worthy of clinical promotion. 2022 Vol. 29 (13): 32-35转43 [Abstract] ( 30 ) HTML (1 KB)  PDF (736 KB)  ( 131 ) 36 Clinical effect of quadruple regimen with different frequency in the eradication of Helicobacter pylori ZENG Xiaohui1 HUANG Liling2 PENG Songxing Objective To investigate the application effect of quadruple regimen with different medication frequency in the eradication of Helicobacter pylori. Methods A total of 160 patients of peptic ulcer diagnosed with helicobacter pylori infection in the outpatient department of Shenzhen Longgang Central Hospital from August 2018 to July 2020 were selected as the research subjects and divided into observation group (80 cases) and control group (80 cases) by the random number table method. The observation group was given a quadruple regimen (Esomeprazole Magnesium + Bismuth Potassium Citrate + Clarithromycin + Levofloxacin) four times daily, while the control group was given the same quadruple regimen twice daily for 14 days, and the eradication rate of Helicobacter pylori and the incidence of adverse reactions were compared between the two groups. Results The eradication rate of Helicobacter pylori in the observation group was higher than that in the control group, the difference was statistically significant (P<0.05), and the total incidence of adverse reactions in the observation group was lower than that in the control group, the difference was statistically significant (P<0.05). Conclusions A modified quadruple regimen of four times daily increased the eradication rate of Helicobacter pylori，and with the better safety，Which is especially suitable for patients with penicillin allergy. 2022 Vol. 29 (13): 36-39 [Abstract] ( 32 ) HTML (1 KB)  PDF (456 KB)  ( 131 ) 40 Clinical effect of Ligustrazine Injection combined with Nicorandil in the treatment of coronary heart disease and angina pectoris ZHANG Ying1 YU Zhisong1 LI Yan Objective To investigate the effect of Ligustrazine Injection on acute heart failure and its effect on cardiac function and hemodynamics. Methods A total of 115 patients with acute heart failure treated in No.909 Hospital of the Joint Logistics Support Force of the PLA and Zhangzhou Hospital Affiliated to Fujian Medical University from June 2018 to June 2021 were divided into Ligustrazine group(58 cases)and control group(57 cases)according to random number table method. The patients in the control group were treated with routine treatment, and the patients in the Ligustrazine group were treated with routine treatment plus Ligustrazine Injection. The clinical efficacy, cardiac function and hemodynamic indexes of the two groups were compared before and after 10 d of treatment. Results The total effective rate in the Ligustrazine group was higher than that in the control group, and the difference was statistically significant(P<0.05). After treatment, the left ventricular end diastolic and systolic diameters of the two groups were shorter than those of before treatment, the left ventricular ejection fraction and stroke output of the two groups were higher than those before treatment, and the left ventricular end diastolic and systolic diameters of the Ligustrazine group were shorter than those of the control group, the left ventricular ejection fraction and stroke output of the Ligustrazine group were higher than those of the control group, the differences were statistically significant (P<0.05). After treatment, the mean pulmonary artery pressure, central venous pressure, systemic circulation resistance and pulmonary circulation resistance of the two groups were lower than those before treatment, and the indexes of the Ligustrazine group were lower than those of the control group, and the differences were statistically significant (P<0.05). Conclusion Ligustrazine Injection is effective in the treatment of acute heart failure. It can effectively improve the indexes of cardiac function and hemodynamics in patients with acute heart failure, and it′s worthy of further study. 2022 Vol. 29 (13): 40-43 [Abstract] ( 29 ) HTML (1 KB)  PDF (439 KB)  ( 29 ) 44 Relationship between fragmented QRS complex and cardiac function in patients with myocardial infarction JIA Yinghong Objective To investigate the relationship between fragmented QRS complex (fQRS) and cardiac function in patients with myocardial infarction. Methods A total of 63 inpatients with acute myocardial infarction in Wuxi Huishan District People′s Hospital from January 2017 to January 2020 were selected as the research objects. Electrocardiography (ECG) screening was performed. According to the ECG results, they were divided into the observation group (with fQRS, 28 cases) and the control group (non fQRS, 35 cases). Cardiac function test related data were compared between the two groups, and the relationship between the presence or absence of fQRS and cardiac function of patients with myocardial infarction was analyzed, and the effect of the presence of fQRS on left ventricular systolic function of patients was assessed. Results The left ventricular ejection fraction (LVEF) values in the observation group were lower than those in the control group, the differences were statistically significant (P＜0.05). The observation group had a higher proportion of people with depressed cardiac function than the control group, the difference was statistically significant(P＜0.05). The proportion of moderate to severe cardiac dysfunction in the observation group was higher than that in the control group, the difference was statistically significant (P＜0.05). Conclusion The appearance of fQRS on ECG is closely related to cardiac dysfunction in patients with myocardial infarction, fQRS has a direct effect on left ventricular systolic function, and patients with acute myocardial infarction presenting with fQRS will have more likely to have moderate to severe left ventricular systolic function, which can be clinically used as an element for evaluating the longterm prognosis of patients. 2022 Vol. 29 (13): 44-46转50 [Abstract] ( 33 ) HTML (1 KB)  PDF (461 KB)  ( 33 ) 47 Characteristics of 24 h ambulatory blood pressure variability and the occurrence of cardiovascular and cerebrovascular events in elderly hypertensive patients with different degrees ZHENG Che CHEN Huanzhao CHEN Runsheng LIN Canxin ZHENG Bin Objective To investigate the characteristics of 24 h ambulatory blood pressure variability and the occurrence of cardiovascular and cerebrovascular events in elderly hypertensive patients with different degrees. Methods A total of 120 elderly hypertensive patients in Dongfeng Overseas Chinese Hospital from June 2017 to December 2018 were selected as research objects. According to the hypertension grade standard, they were divided into grade Ⅰ, gradeⅡand grade Ⅲgroups, with 40 cases in each group. All patients were applied dynamics. The ECG blood pressure recorder accurately records the 24 h ambulatory blood pressure, analyzes its variation characteristics and compares the occurrence of cardiovascular and cerebrovascular events among the three groups of patients. Results The diastolic blood pressure, the systolic blood pressure, the standard deviation (SD) of the diastolic blood pressure-ambulatory blood pressure curve, the coefficient of variability (CV) of the diastolic blood pressure-ambulatory blood pressure curve, the systolic blood pressure-CV and the systolic blood pressure-SD in the Ⅱand Ⅲgroups were higher than those of the grade Ⅰgroup, and the grade Ⅲgroup was higher than the grade Ⅱgroup, the differences were statistically significant (P<0.05). Comparison of the incidence of myocardial infarction and cerebral hemorrhage among the three groups was statistically significant (P<0.05). The incidence of myocardial infarction and cerebral hemorrhage in the grade Ⅲgroup was higher than that in the grade Ⅰgroup, and the difference was statistically significant (P<0.017). Conclusion The blood pressure variability index is the main influencing factor for the occurrence of cardiovascular and cerebrovascular events in elderly hypertensive people independent of blood pressure. The greater the blood pressure variability,the higher the incidence of cardiovascular and cerebrovascular events. Therefore, we should focus on the variability of blood pressure on the basis of strengthening the grading management of blood pressure, and propose targeted treatment methods for blood pressure levels and blood pressure variability to control the occurrence of diseases. 2022 Vol. 29 (13): 47-50 [Abstract] ( 33 ) HTML (1 KB)  PDF (451 KB)  ( 35 ) 51 Application of Argatroban adjuvant therapy in acute ischemic stroke patients with early deterioration of neurological function XU Shu ZHANG Wenjun Objective To investigate the effect of Agattroban adjuvant therapy in acute ischemic stroke patients with early neurological deterioration. Methods A total of 160 patients with acute ischemic stroke admitted to the First People′s Hospital of Zhangjiagang City from June 2018 to June 2021 were selected as the study subjects. They were divided into group A and group B by random touch ball method, with 80 cases in each group. Patients in group B were treated with Aspirin, and patients in group A were treated with Agattroban. The degree of cerebral nerve function defect, the level of fibrinogen (FIB) and neuropeptide (NPY) in the two groups were compared. Results The modified Edinburgh-Scandinavian neurological impairment score scale (MIESSS) scores of the two groups after treatment were lower than those before treatment, and the MIESSS score of group A was lower than that in the group B, the differences were statistically significant (P<0.05). After treatment, FIB and NPY levels in the two groups were lower than those before treatment, and FIB and NPY levels in group A were lower than those in group B, the differences were statistically significant (P<0.05). Conclusion In acute ischemic stroke patients with early neurological deterioration, adjunctive treatment with Agattroban can significantly reduce the degree of cerebral neurological impairment and regulate the level of FIB and NPY. 2022 Vol. 29 (13): 51-53 [Abstract] ( 27 ) HTML (1 KB)  PDF (552 KB)  ( 105 ) 54 Effect of anaesthetic to electrical stimulus time interval on electrographic seizure duration in modified electro-convulsive therapy ZHOU Shaoyu GAO Danqing FENG Zhenxiao ZHANG Aiying Objective To explore the effect of anaesthetic to electrical stimulus time interval (ASTI) on electrographic seizure duration (ESD) in modified electro-convulsive therapy (MECT). Methods A total of 102 schizophrenic patients treated with MECT in Shanghai Jinshan Mental Health Center from July 2017 to February 2021 were selected as the research objects. A real-world clinical research was used to record the ASTI and ESD of all patients during 6 consecutive MECT (612 times). The effect of ASTI on ESD were analyzed, and the regulatory effect of gender and treatment times on this effect were further investigated. Results ESD of male schizophrenic patients was longer than that of female patients, the difference was statistically significant (P＜0.05). The first and second ESD were longer than the sixth ESD, and the difference was statistically significant (P＜0.05). There was no significant difference between the ESD at the 3rd, 4th and 5th treatments and the ESD at the 6th treatment (P＞0.05). ASTI positively affected ESD, and the difference was statistically significant (P ＜0.05). Energy negatively affected ESD, the difference was statistically significant (P＜0.05). There was no significant difference in the effects of body weight, age, Propofol dose and SC dose on ESD (P＞0.05). ASTI had a positive effect on ESD in male and female patients with schizophrenia (P＜0.05). The effect on male schizophrenic patients was greater than that on female patients, and the difference between the two influence coefficients was 0.013, the difference was statistically significant (P＜0.05). ASTI positively affected ESD during the 1st treatment to 6th treatment (P ＜0.05). With the increase of the number of treatments, the influence coefficient gradually decreased, and the difference between the first and sixth influence coefficient was 0.072, the difference was statistically significant (P＜0.05). Conclusions Appropriate extension of ASTI can increase the ESD induced by MECT and improve the quality of epileptic seizures, which is worthy of clinical promotion. 2022 Vol. 29 (13): 54-57 [Abstract] ( 39 ) HTML (1 KB)  PDF (614 KB)  ( 28 ) 58 Clinical effect of Ginkgo Armillaria Oral Solution combined with Flupentixol and Melitracen in the treatment of post ischemic stroke depression XIAO Lichun1 CAI Jun1 WU Haiping2 ZHU Mingguang1 TANG Yuying2 TIAN Keyao1 XIE Dongyang Objective To investigate the clinical efficacy of Ginkgo Armillaria Oral Solution combined with Flupentixol and Melitracen in the treatment of post ischemic stroke depression. Methods A total of 100 patients with mild to moderate post ischemic stroke depression admitted to the Department of Neurology in the Second Affiliated Hospital of Gannan Medical University from January 2019 to February 2020 were selected as subjects. They were divided into two groups with 50 cases in each group by random number parity method. The patients in the two groups were given routine treatment and necessary rehabilitation treatment. The control group was treated with Flupentixol and Melitracen on the basis of routine treatment, and the experimental group was treated with Flupentixol and Melitracen and Ginkgo Armillaria Oral Solution on the basis of routine treatment. The patients in the two groups were treated continuously for 4 weeks. Hamilton depression scale (HAMD) score and Barthel index (BI) were compared between the two groups before and after treatment.The clinical efficacy of the two groups was compared.The incidence of adverse reactions was compared between the two groups. Results The HAMD scores of the two groups after treatment were lower than those before treatment, BI scores of the two groups after treatment were higher than those before treatment, the differences were statistically significant (P<0.05). After treatment, HAMD score of experimental group was lower than that of control group, BI score was higher than that of control group, the differences were statistically significant (P<0.05). The total effective rate of experimental group (90.00%) was higher than that of control group (74.00%), and the difference was statistically significant (P＜0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P＞0.05). Conclusion The effect of Ginkgo Armillaria Oral Solution combined with Flupentixol and Melitracen in the treatment of post ischemic stroke depression is better than that of Flupentixol and Melitracen alone, and it can improve the patients′ ability of daily living and depression symptoms at 4 weeks. 2022 Vol. 29 (13): 58-61转65 [Abstract] ( 31 ) HTML (1 KB)  PDF (585 KB)  ( 55 ) 62 Influence of Ligustrazine Hydrochloride Injection combined with Ureklin on hemorheology and thromboelastogram in patients with acute cerebral infarction KE Laishun1 LIU Huabin1 TU Yanfen Objective To investigate the influence of Ligustrazine Hydrochloride Injection combined with Urecolin on hemorheology and thromboelastogram in patients with acute cerebral infarction. Methods A total of 96 patients with acute cerebral infarction treated in Zhangzhou Third Hospital from January to December 2020 were selected as the research objects. They were divided into the control group (48 cases) and the observation group (48 cases) according to random number table method. The control group was treated with Urecolin single drug therapy, and the observation group was treated with Ligustrazine Hydrochloride Injection combined with Urecolin therapy. The total effective rate,hemorheological indexes and thromboelastogram indexes of the two groups were compared. Results The total effective rate of the observation group was higher than that of the control group, the difference was statistically significant (P＜0.05). The four indexes of high shear whole blood viscosity, plasma viscosity, fibrinogen and low shear whole blood viscosity in the observation group were lower than those in the control group, the differences were statistically significant(P＜0.05). The coagulation reaction time of the observation group was shorter than that of the control group, the formation time of blood cell agglutination block of the observation group was longer than that of the control group, the formation rate of blood cell agglutination block of the observation group was lower than that of the control group, and the maximum blood clot intensity of the observation group was shorter than that of the control group, the differences were statistically significant (P＜0.05). Conclusion In the clinical treatment of patients with acute cerebral infarction, Ligustrazine Hydrochloride Injection combined with Ureklin has a good effect. After its implementation, the total effective rate is higher, and it can more effectively improve the hemorheology and thromboelastogram indexes of patients. It has more advantages and is worthy to be popularized in clinical application. 2022 Vol. 29 (13): 62-65 [Abstract] ( 34 ) HTML (1 KB)  PDF (588 KB)  ( 19 ) 66 Prognostic value of Dragon score for intravenous thrombolysis in acute ischemic stroke ZHU Shaowen LIU Shiwu LU Zhanhong Objective To evaluate the prognostic value of Dragon score in patients with acute ischemic stroke (AIS)treated with intravenous urokinase thrombolytic therapy. Methods A total of 82 AIS patients hospitalized in Department of Neurology, People′s Hospital of Yingde City, Guangdong Province from January 1, 2019 to October 31, 2020 who received intravenous thrombolysis of urokinase 1 000 000 units were selected as the research objects. Dragon score was performed on each enrolled patient. The modified Rankin score (mRS) was followed up one month after thrombolytic therapy. The mRS score was used as the prognostic index, mRS ＜3 points was defined as good prognosis, mRS＞4 was defined as bad outcome, and the relationship between Dragon score and prognosis of thrombolytic therapy was evaluated. Results After 1 month, 57 patients (69.51%) had good outcome (mRS ＜3 points) and 13 patients (15.85%) had bad outcome (mRS ＞4 points). Pearson correlation coefficient analysis showed that there was a positive correlation between mRS score and Dragon score after 1 month of thrombolysis (P＜0.05). The area under the receiver operating characteristic (ROC) curve (AUC) for predicting good outcome after 1 month was 0.866 (95%CI: 0.778-0.954), when Dragon score＜3 points, its sensitivity and specificity were 76.0% and 82.5%, positive predictive value and negative predictive value were 65.5% and 88.7%, respectively. AUC was 0.980 (95%CI: 0.952-1.008) for predicting adverse prognosis after 1 month. The best prediction was achieved when Dragon score ＞4 points, the sensitivity, specificity, positive predictive value and negative predictive value were 92.3%, 94.2%, 75% and 98.5% respectively. Conclusion The Dragon score is highly accurate in predicting the prognosis of venous thrombolysis in patients with acute cerebral arterial thrombosis,with a higher score indicative of a poorer prognosis. 2022 Vol. 29 (13): 66-69 [Abstract] ( 34 ) HTML (1 KB)  PDF (614 KB)  ( 26 ) 70 Application effect of Olanzapine combined with Fluoxetine in the treatment of bipolar disorder ZHANG Wenjing Objective To investigate the application effect of Olanzapine combined with Fluoxetine in the treatment of bipolar disorder. Methods A total of 100 patients with bipolar disorder treated in the Third Hospital of Inner Mongolia Autonomous Region from February 2019 to June 2021 were selected as the research objects. They were divided into observation group and control group by computer two-color ball grouping method, with 50 patients in each group. Observation group was treated with Olanzapine combined with Fluoxetine, while control group was treated with Lithium Carbonate. The symptom index, clinical treatment effect and adverse drug reaction were compared between the two groups. Results After treatment, Bech-Rafaelsen mania rating scale (BRMS) score and positive and negative symptom scale (PANSS) score in the observation group were lower than those in the control group, and the differences were statistically significant (P＜0.05). The total effective rate of clinical treatment in observation group was higher than that in control group, the difference was statistically significant (P＜0.05). There was no statistically significant difference in the total incidence of adverse reactions between the two groups (P＞0.05). Conclusion Olanzapine combined with Fluoxetine can inhibit the manic state of patients with bipolar disorder, improve the clinical symptoms of patients, the treatment effect is significant, and medication safety, high feasibility value. 2022 Vol. 29 (13): 70-72 [Abstract] ( 34 ) HTML (1 KB)  PDF (551 KB)  ( 28 ) 73 Influence of Lanthanum Carbonate Chewable Tablets combined with Paricalcitol on serum calcium, phosphorus and bone mineral density in patients with maintenance hemodialysis ZHANG Huilin ZHOU Linjun WU Tianzhu ZHANG Desheng LIU Yong MAO Qinghua GUO Quanfu HUA Ruifang Objective To investigate the influence of Lanthanum Carbonate Chewable Tablets combined with Paricalcitol on serum calcium, phosphorus and bone mineral density in patients with maintenance hemodialysis (MHD). Methods A total of 90 patients with MHD confirmed from May 2020 to May 2021 in Ganzhou Municipal Hospital were enrolled. They were divided into group A (30 cases), group B (30 cases) and group C (30 cases) by random number table method. Group A was given Lanthanum Carbonate Chewable Tables, group B was given Paricalcitol, and group C was given Lanthanum Carbonate Chewable Tables combined with Paricalcitol. All patients were continuously treated for 1 months. The score of kidney disease quality of life short form (KDQOL-SF), left hip joint bone mineral density (BMD),triceps skin fold thickness (TSF), mid-arm muscle circumference (MAC), calcium and phosphorus metabolism indexes,nutritional indexes and the total incidence of adverse reactions were compared among three groups before and after treatment. Results After treatment, the KDQOL-SF scores and BMD in group C were higher than those in group A and group B, and which were higher than those before treatment, the differences were statistically significant (P＜0.05).There were no significant differences in the KDQOL-SF scores and BMD between group A and group B before and after treatment (P＞0.05). After treatment, TSF and MAC in group C were greater than those in group A and group B, and which were larger than those before treatment, the differences were statistically significant (P＜0.05). There were no significant differences in TSF and MAC between group A and group B before and after treatment (P＞0.05). After treatment, there was no statistically significant difference in blood calcium levels between the three groups and before and after treatment (P＞0.05). After treatment, blood phosphorus in group C was lower than that before treatment, and which were lower than those in group A and group B, the differences were statistically significant (P＜0.05). The creatinine level in group C after treatment was lower than that in group A and group B, the albumin level in group C after treatment was higher than that in group A and group B, and the creatinine levels in the three groups after treaatment were lwer than those before treatment, the albumin levels in the three groups after treatment were higher than those before treatment, the differences were statistically significant (P＜0.05). There were no significant difference in the total incidence of adverse reactions among the three groups (P＞0.05). Conclusion The Lanthanum Carbonate Chewable Tablets combined with Paricalcitol can effectively improve the levels of serum phosphorus, BMD, and can effectively improve nutritional status and quality of life in patients undergoing MHD. 2022 Vol. 29 (13): 73-76转80 [Abstract] ( 33 ) HTML (1 KB)  PDF (648 KB)  ( 81 ) 77 Clinical significance of changes of serum procalcitonin and C-reactive protein levels in patients after percutaneous nephrolithotomy for early diagnosis of systemic inflammatory response syndrome PENG Weihua LAI Guoyan CAO Didi ZHANG Zhonghua Objective To investigate the clinical significance of changes in serum procalcitonin (PCT) and C-reactive protein (CRP) levels in the early diagnosis of systemic inflammatory response syndrome (SIRS) in patients after percutaneous nephrolithotomy. Methods A total of 40 patients with SIRS after percutaneous nephrolithotomy in Xinyu People′s Hospital from February 2018 to February 2020 were retrospectively selected as the observation group, and 40 patients who had not undergone percutaneous nephrolithotomy during the same period were selected as the control group. The data of patients with SIRS were included in the control group. All patients were tested for serum PCT and CRP levels at 24 h before surgery, 2 h after surgery and 24 h after surgery. Serum PCT and CRP levels were compared between the two groups, the value of serum PCT and CRP levels in the early diagnosis of SIRS after percutaneous nephrolithotomy were analyzed. Results Twenty four hours after operation, the serum PCT and CRP levels of the two groups were higher than those at 24 h before operation and 2 h after operation, the serum PCT and CRP levels of the two groups at 2 h after operation were higher than those at 24 h before operation, the serum PCT and CRP levels in the observation group at 2 and 24 h after operation were higher than those in the control group, and the differences were statistically significant (P＜0.05). The area under the curve values of serum PCT and CRP levels and combined detection were 0.849, 0.826, 0.861, respectively. Conclusion The detection of serum PCT and CRP levels has a high application value in the early diagnosis of SIRS in patients after percutaneous nephrolithotomy, the higher the serum PCT and CRP levels, the greater the risk of SIRS after surgery. 2022 Vol. 29 (13): 77-80 [Abstract] ( 35 ) HTML (1 KB)  PDF (621 KB)  ( 23 ) 81 Application effect comparison of percutaneous renal cyst decapitation and retroperitoneal laparoscopic renal cyst decapitation in simple renal cyst HUANG Zhen WU Yandan CHEN Shulin Objective To investigate the efficacy of percutaneous renal cyst unroofing decompression and retroperitoneal laparoscopic renal cyst unroofing decompression in the treatment of simple renal cyst. Methods The clinical data of 49 patients with simple renal cyst treated in the Department of Urology of Yingde People′s Hospital of Guangdong Province from April 2017 to May 2021 were analyzed retrospectively. According to different operation methods, they were divided into percutaneous group (24 cases) and laparoscopic group (25 cases). The patients in the percutaneous group underwent percutaneous renal cyst puncture and decompression, The patients in the laparoscopic group underwent retroperitoneal laparoscopic renal cyst decapitation and decompression, and were followed up for 6 months. The perioperative indexes, total incidence of postoperative complications and recurrence rate were compared between the two groups. Results The operation time and postoperative hospital stay in the percutaneous group were shorter than those in the laparoscopic group, the amount of intraoperative bleeding was less than that in the laparoscopic group, the postoperative drainage volume was more than that in the laparoscopic group, and the score of visual analogue scale(VAS) was lower than that in the laparoscopic group, with statistical significances (P<0.05). The total incidence of postoperative complications in the percutaneous group was 4.17% and the recurrence rate was 0, there were no significant difference compared with 4.00% and 4.00% in the laparoscopic group (P>0.05). Conclusion Both percutaneous renal cyst decompression and retroperitoneal laparoscopic renal cyst decompression can treat simple renal cyst, but the former has simple operation, less postoperative pain, less complications and high safety, which is worthy of popularization. 2022 Vol. 29 (13): 81-83 [Abstract] ( 28 ) HTML (1 KB)  PDF (576 KB)  ( 98 ) 84 Effect and security of retroperitoneal laparoscopic renal cyst puncture and sclerotherapy combined with unroofing in patients with simple renal cyst YANG Jun LI Ganhong JIANG Hua ZENG Jiaqing YANG Xianhong Objective To investigate the clinical effect and security of retroperitoneal laparoscopic renal cyst puncture combined and sclerotherapy with unroofing in patients with simple renal cyst. Methods A total of 60 patients with simple renal cyst treated in the Fifth Affiliated Hospital of Zunyi Medical University (Zhuhai) from September 2019 to September 2020 were selected as the research objects, and they were divided into the control group (n=30) and the observation group (n=30) according to random number table method. The patients in the control group were treated with retroperitoneal laparoscopic renal cyst unroofing, the patients in the observation group received retroperitoneal laparoscopic renal cyst puncture and sclerotherapy combined with unroofing. The two groups were observed for 6 months. The total effective rate, bleeding volume during operation, drainage volume, hospital stay and cost of the two groups were compared, and the total incidence of complications and the recurrence rate of the two groups were compared. Results The total effective rate of the observation group was higher than that of the control group, the difference was statistically significant (P＜0.05). The hospital stay of the observation group were shorter than that of the control group, and the amount of bleeding during operation, drainage volume and cost of the observation group were less than those of the control group, the differences were statistically significant (P＜0.05). The total incidence of complications and the recurrence rate in the observation group were lower than those in the control group, the differences were statistically significant (P＜0.05). Conclusion Retroperitoneal laparoscopic renal cyst puncture and sclerotherapy combined with unroofing is effective in the treatment of simple renal cyst, which can reduce the size of the cyst, accelerate the postoperative recovery, reduce the recurrence rate, has high safety and low medical cost, and is worthy of clinical promotion. 2022 Vol. 29 (13): 84-86转90 [Abstract] ( 31 ) HTML (1 KB)  PDF (979 KB)  ( 99 ) 87 Influence of dorsal vein complex free suture ligation technique on urinary control function of patients after laparoscopic radical prostatectomy HONG Zhaozhan1 CEN Haifeng1 SITU Chunmei Objective To investigate the influence of dorsal vein complex (DVC) free suture ligation technique on the urinary control function of patients after laparoscopic radical prostatectomy. Methods From January 2019 to December 2019, 60 cases of laparoscopic radical prostatectomy received by Yangjiang People′s Hospital were selected as the research objects, and they were divided into the control group and the observation group according to the random number table method, with 30 patients in each group, The control group was given conventional suture technique, and the observation group was given the technique of free suture. The operation-related indexes, urinary control ability, improvement of sexual function and the total incidence of complications were compared between the two groups of patients.Results The urinary catheter indwelling time, operation time, and postoperative hospital stay in the observation group were shorter than those in the control group, the intraoperative blood loss in the observation group was less than that in the control group, and the differences were statistically significant (P＜0.05). After treatment, the International Consultation on Incontinence questionnaire-short form (ICIQ-SF) scores of the two groups were lower than those before treatment, and the extended prostate cancer index composite-urinary inventory (EPIC-UIN) scores of the two groups were higher than those before treatment, and the ICIQ-SF score of the observation group after treatment was lower than that of the control group, and the EPIC-UIN score of the observation group after treatment was higher than that of the control group, and the differences were statistically significant (P＜0.05). After treatment, the international index of erectile function-5 (IIEF-5) scores of the two groups were higher than those before treatment, the international prostate symptom scores (IPSS) of the two groups were lower than those before treatment, and the IIEF-5 score of the observation group after treatment was higher than that of the control group, and the IPSS score of the observation group after treatment was lower than that of the control group, and the differences were statistically significant (P＜0.05). The total incidence of complications in the observation group was lower than that of the control group, and the difference was statistically significant (P＜0.05 ). Conclusion The application of DVC free suture ligation technique to patients undergoing laparoscopic radical prostatectomy can minimize the damage to the body, which is beneficial to improve the patient′s postoperative urinary control ability, improve sexual function, and reduce the occurrence of complications. 2022 Vol. 29 (13): 87-90 [Abstract] ( 30 ) HTML (1 KB)  PDF (626 KB)  ( 94 ) 91 Analysis of the efficacy of external-to-internal trans-obturator tape in the treatment of stress urinary incontinence in women and the related factors affecting the recovery time of postoperative voiding function CHANG Xuefeng； DING Li ；GENG Xiangyang； YANG Jiajia； WANG Xiao； DU Yongqiang Objective To investigate the efficacy and safety of the treatment of female stress urinary incontinence (SUI)by external-to-internal trans-obturator tape (TOT), and to analyse the factors affecting the recovery of postoperative voiding function. Methods A total of 114 female patients with SUI treated in Fuyang People′s Hospital Affiliated to Anhui Medical University from January 2015 to August 2021 were retrospectively selected as the research objects. They were divided into the observation group (63 cases) and the control group (51 cases) according to different surgical methods. The observation group was given TOT method, and the control group was given tension-free vaginal tape-obturator technique (TVT-O) method. The patients′ surgical treatment results, intraoperative indexes and postoperative complications were analyzed, and the factors affecting the recovery time of urinary function after surgery in the observation group were analyzed. Results There was no significant difference in the total effective rate between the two groups(P＞0.05). There were no significant differences in the intraoperative bleeding, operation time and postoperative hospital stay between the two groups (P＞0.05). The overall incidence of postoperative complications in the observation group was lower than that in the control group, and the difference was statistically significant (P＜0.05). Age, menopause, internal urethral sphincter function defect, high urethral activity,preoperative residual urine volume, and maximum urinary flow rate were all independent influencing factors on the recovery time of voiding function after TOT in female SUI patients (P＜0.05). Conclusion Both TOT and TVT-O have the same efficacy in the treatment of SUI, but TOT is safer. The recovery time of micturition function after TOT is affected by multiple factors. Corresponding clinical intervention measures can be taken to promote patients to recover normal micturition function faster. 2022 Vol. 29 (13): 91-95 [Abstract] ( 31 ) HTML (1 KB)  PDF (642 KB)  ( 47 ) 96 Application of ultrasound guided adductor tube saphenous nerve block in day surgery for laser closure of great saphenous vein ZHOU Limin WEI Lingying ZHAO Guoguang LI Guohua LI Bo YANG Pengpeng Objective To investigate the effect of ultrasound-guided adductor tube saphenous nerve block in daytime surgery for laser closure of the great saphenous vein. Methods From January to May 2021, 134 patients with varicose veins of the lower extremities who underwent day surgery on the Second Affiliated Hospital of Shandong First Medical University with laser closure of the great saphenous vein were selected as the research objects. According to random number table method, they were divided into observation group and control group, 67 cases in each group. The two groups were blocked under ultrasound guidance. The control group received femoral nerve block, and the observation group received adductor tube saphenous nerve block. The patient was discharged from the hospital after observation.The hemodynamics, pain degree, muscle strength of the lower limbs, first getting out of bed after operation and hospitalization time were compared between the two groups. Results There were no significant differences in heart rate and mean arterial pressure between the two groups before surgery, at the beginning of surgery and 15 min after admission to ward (P>0.05). The visual analog scale (VAS) score of the observation group was lower than that of the control group during operation and 2, 4 and 8 h after operation, and the differences were statistically significant (P<0.05). The muscle strength score of lower limbs in the observation group was higher than that in the control group at 2, 4 and 8 h after wards transfer, and the difference was statistically significant (P<0.05). The first postoperative ambulation and hospitalization time in the observation group were shorter than those in the control group, and the differences were statistically significant (P<0.05). Conclusion Ultrasound-guided adductor tube saphenous nerve block has a definite effect in daytime laser closure of the great saphenous vein, which can ensure the patient′s hemodynamic stability, reduce pain, and have a slight impact on lower limb motor function. Patients can get out of bed earlier after surgery and speed up their recovery after surgery. 2022 Vol. 29 (13): 96-98转102 [Abstract] ( 30 ) HTML (1 KB)  PDF (421 KB)  ( 37 ) 99 Clinical effect of single point and single paravertebral block after percutaneous nephrolithotomy KONG Xiangyun SUI Cheng ZHOU Jing CUI Jinhua Objective To investigate the clinical effect of single point and single paravertebral block after percutaneous nephrolithotomy. Methods A total of 60 percutaneous nephrolithotomy patients admitted to the Department of Anesthesiology, Xinhua Hospital Affiliated to Dalian University from September 2019 to February 2020 were selected as the study subjects, and were divided into control group (30 cases) and observation group (30 cases) by random number table method. The control group was treated with intraspinal anesthesia, and the observation group was treated with ultrasound-guided single point single paravertebral block. Surgical indicators, visual analogue scale (VAS) score, vital signs before anesthesia (T0), 10 min after anesthesia (T1), after the establishment of lithotripsy channel (T2), 10 min after the beginning of lithotripsy (T3), and at the end of lithotripsy (T4) were compared between the two groups. Results The operation time, postoperative exhaust time and hospital stay in the observation group were shorter than those in the control group, and the amount of intraoperative blood loss was less than that in the control group, the differences were statistically significant (P＜0.05). Preoperative comparison of VAS scores between the two groups showed no statistical significance (P＞0.05). At 6, 12 and 24 h postoperatively, VAS scores in both groups were lower than those before operation, and VAS score in observation group was lower than that in control group, the differences were statistically significant (P＜0.05). At T0, there were no significant differences in mean arterial pressure (MAP) and heart rate (HR) between the two groups (P＞0.05). The MAP of T1 and T4 in observation group were higher than those in control group, while the MAP of T2 and T3 were lower than those in control group, the HR of T1 in observation group was higher than that in control group, and the HR of T2-T4 were lower than those in control group, the differences were statistically significant(P＜0.05). Conclusion Ultrasound-guided single point single thoracic paravertebral block can shorten the operation time and hospital stay, reduce the amount of bleeding, reduce pain, and have little effect on arterial pressure and heart rate. 2022 Vol. 29 (13): 99-102 [Abstract] ( 31 ) HTML (1 KB)  PDF (412 KB)  ( 28 ) 103 Efficacy of coronary CT angiography plaque characteristics and stenosis in predicting myocardial ischemia ZHAO Hui ZHANG Jiquan Objective To investigate the efficacy of coronary CT angiography (CCTA) in predicting myocardial ischemia with Coronary plaque characteristics and stenosis. Methods From January 2019 to December 2020, 88 patients with suspected or known coronary heart disease (196 diseased vessels) admitted to Xianning First People′s Hospital were selected as the study subjects. After admission, all the enrolled patients received CCTA, coronary artery angiography(CAG)and Fractional flow reserve(FFR)examination,and the gold standard was the cardiac FFR value.According to FFR value, they were divided into ischemic group (n=45, 99 vessels with lesion, FFR value ≥0.8) and non-ischemic group(n=43, 97 vessels with lesion, FFR value <0.8). The clinical baseline data of the two groups were retrospectively analyzed, and the characteristics of CCTA plaque and the stenosis of the two groups were compared. The value of THE characteristics of CCTA plaque and the stenosis rate in the diagnosis of myocardial ischemia were analyzed. Results The degree of stenosis in the ischemic group was more severe than that in the non-ischemic group, and the difference was statistically significant (P<0.05). The results showed that the vascular plaque load, plaque volume and calcification score in the ischemic group were higher than those in the non-ischemic group, and the lesion length was lower than that in the non-ischemic group, with statistical significances (P<0.05). CT high-risk plaque and low-density plaque were more than those in the non-ischemic group, with statistical significances (P<0.05). ROC analysis showed that the AUC of CCTA lesion stenosis rate (>75% stenosis), CT high-risk plaque, lesion length and combined detection in predicting myocardial ischemia were 0.626, 0.605, 0.696 and 0.759, respectively. Conclusion CCTA has good efficacy in predicting myocardial ischemia in patients with vascular plaque characteristics and vascular stenosis rate, and the combination of CCTA and CCTA can be used as an important diagnostic index of myocardial ischemia. 2022 Vol. 29 (13): 103-105转109 [Abstract] ( 33 ) HTML (1 KB)  PDF (705 KB)  ( 173 ) 106 Diagnostic value of diffusion tensor imaging in differential of hyperacute and acute ischemic cerebral infarction LIU Lanxiang Objective To explore the diagnostic value of diffusion tensor imaging (DTI) in the differential of hyperacute and acute ischemic cerebral infarction (CIS). Methods A total of 63 patients with CIS within 72 hours of onset treated in Guangzhou First People′s Hospital from January to August 2020 were selected as the research objects, and they were divided into hyperacute CIS group (24 cases) and acute CIS group (39 cases) according to their time phases. Both groups were examined by magnetic resonance DTI. The tractional anisotropy index (FA), volume ratio anisotropy index(VRA), average diffusion coefficient (DCavg), exponential attenuation index (Exat) and other related parameters at the focus and the opposite side of the mirror were counted, and the relative value of FA (rFA), the relative value of VRA(rVRA) and the relative value of DCavg (rDCavg) were compared between the two groups. Results FA, VRA and DCavg in the focus of acute CIS group were lower than those on the opposite side of the mirror image, while Exat was higher than that on the opposite side of the mirror image, the differences were statistically significant (P<0.05). DCavg at the focus of hyperacute CIS group was lower than that on the opposite side of the mirror, Exat was higher than that on the opposite side of the mirror, the differences were statistically significant (P<0.05), there were no significant differences in FA and VRA between the focus and the opposite side of the mirror (P>0.05). rFA, rVRA and rDCavg at the focus and the opposite side of the mirror in hyperacute CIS group were higher than those in acute CIS group, the differences were statistically significant (P<0.05). There was no significant difference in rexat between the two groups (P>0.05). The area under the curve of rFA, rVRA and rDCavg in differentiating hyperacute CIS and acute CIS were 0.953, 0.971 and 0.832 respectively. Conclusion There are some differences in DTI parameters between hyperacute and acute ischemic CIS, and DTI related parameters can provide a good reference value for the differential diagnosis of them. 2022 Vol. 29 (13): 106-109 [Abstract] ( 41 ) HTML (1 KB)  PDF (403 KB)  ( 88 ) 110 Effect of Kanglaite Injection on immune cell activity in patients with gastric cancer chemotherapy FU Qiang HU Liye WU Jiancheng XIAO Xunli ZHANG Yuan Objective To investigate the effect of Kanglaite Injection on immune cell activity in patients with gastric cancer chemotherapy. Methods A total of 84 patients with advanced gastric cancer admitted to the Affiliated Hospital of Jinggangshan University from October 2019 to August 2021 were selected as the research objects. They were divided into two groups by random number table method, with 42 cases in each group. The control group was treated with conventional Docetaxel combined with Cisplatin chemotherapy, and the treatment group was treated with Kanglaite Injection on the basis of the control group. The curative effect was evaluated during 2 cycles of treatment in both groups.Compared the clinical efficacy of the two groups before treatment and after 2 cycles of treatment, compare the immune function levels of the two groups(T lymphocyte subsets[CD3+,CD4+,CD8+,CD4+/CD8+])before treatment and during 2 cycles of treatment, record the occurrence of side effects in the two groups during treatment. Results The disease control rate of patients in the treatment group was higher than that of the control group during the 2 cycles of treatment, and the overall treatment effect was better than that of the control group, the differences were statistically significant (P<0.05).There were no significant differences in the CD3+,CD4+,CD8+,CD4+/CD8+between two groups before treatment(P>0.05). The CD8+ of two groups during the 2 cycles of treatment were higher than those before treatment, and the CD3+,CD4+, CD4+/CD8+ were lower than those before treatment, but the CD8+ of the treatment group was lower than that of the control group, and the CD3+, CD4+, CD4+/CD8+were higher than those of the control group, the differences were statistically significant (P<0.05). During treatment period, the incidence of nausea, vomiting and bone marrow suppression of the treatment group was lower than that of the control group, and the difference was statistically significant (P<0.05).Conclusion Kanglaite Injection assisted in gastric cancer chemotherapy patients can enhance the immune function of patients, improve clinical efficacy, and reduce the occurrence of nausea, vomiting and bone marrow suppression. 2022 Vol. 29 (13): 110-112转116 [Abstract] ( 30 ) HTML (1 KB)  PDF (498 KB)  ( 90 ) 113 Effect of Oxycodone combined with Dexmedetomidine analgesia on uterine contraction and traction pain after cesarean section SONG Hui LIU Jiaoyang Objective The impacts of Oxycodone combined with Dexmedetomidine analgesia on uterine contraction and traction pain after cesarean section. Methods From October 2018 to December 2019, 104 parturients who gave birth by cesarean section in Liaoyang City Central Hospital were selected as the research objects. According to random number table method, they were divided into observation group and control group, with 52 cases in each group, the observation group was treated with Oxycodone combined with Dexmedetomidine for postoperative analgesia, and the control group was treated with Dexmedetomidine for postoperative analgesia. The visual analogue scale (VAS) score, Ramsay sedation score, incidence of adverse reactions, Edinburgh postpartum depression scale (EPDS) score of two groups in the maternal pain were compared. Results At 6, 12, 24, 48 h after operation, the VAS scores of surgical incision pain and uterine contraction pain of the puerpera in the observation group were lower than those in the control group, the differences were statistically significant (P<0.05). There were no significant differences in the Ramsay sedation score and the total incidence of adverse reactions between the two groups at 2, 4, 6, 12, 24, 48 h after operation (P>0.05).The EPDS scores of two groups after operation were lower than those before operation, and the EPDS score of the observation group was lower than that of the control group, the differences were statistically significant (P<0.05).Conclusion The combination of Oxycodone and Dexmedetomidine has a good analgesic effect after cesarean section. It can effectively reduce postoperative uterine contractions and traction pain, relieve postpartum depression, and have fewer adverse reactions. 2022 Vol. 29 (13): 113-116 [Abstract] ( 32 ) HTML (1 KB)  PDF (486 KB)  ( 39 ) 117 Investigation on antimicrobial use of inpatients in Respiratory Department of Nantong Third Hospital Affiliated to Nantong University from 2016 to 2020 ZHU Xixi1 QIAO Jin1▲ XU Li′na Objective To investigate and analyze the use of antibiotics in hospitalized patients in Respiratory Department of Nantong Third Hospital Affiliated to Nantong University from 2016 to 2020, and further strengthen the rational use of antibiotics in respiratory department. Methods According to the requirements of the national special campaign plan for clinical application of antibacterial drugs, prescription automatic screening system (PASS) for rational use of antibiotics in hospital ranked the top 5 in the amount of antibacterial drugs used by inpatients in respiratory department of hospital from 2016 to 2020, the rate of antibacterial drugs used, the intensity of antibacterial drugs used, the rate of microbial samples submitted for examination of inpatients receiving antibacterial drugs, the way of antimicrobial drugs administered statistics and comparison were made on the combined use of antibiotics. Results From 2016 to 2020, the overall consumption of carbapenem antibiotics showed a downward trend, the consumption of Moxifloxacin in quinolone antibiotics decreased year by year, and the consumption of the third generation cephalosporin antibiotics was still at a high level every year, but the consumption of Penicillin and Cephalosporin Enzyme Inhibitors showed an increasing trend year by year. The use rate of antibiotics in inpatients of respiratory medicine decreased year by year, from 89.58% in 2016 to 72.11% in 2020. The use intensity of antibiotics in inpatients of respiratory department also decreased with the decrease of use rate, from 120.94 in 2016 to 89.85 in 2020. The total inspection rate of patients treated with antibiotics, the inspection rate of microbial samples of patients treated with restricted antibiotics and the inspection rate of microbial samples of patients treated with special use antibiotics met the standards every year, and there was an overall upward trend from 2016 to 2020. Intravenous administration was the main mode of administration in hospitalized patients in respiratory department, which was higher than oral administration and other modes of administration. The proportion of single drug use in hospitalized patients in respiratory department was increasing year by year, and the proportion of double, triple and quadruple drugs showed a downward trend as a whole, but the highest proportion was still double drug use. In 2020, the proportion of double drug use had reach 54.67%, which was higher than that of single drug use and other combinations. Conclusion From 2016 to 2020, the utilization rate, use intensity,submission rate and combined use of antibiotics in respiratory department showed continuous improvement. 2022 Vol. 29 (13): 117-121 [Abstract] ( 30 ) HTML (1 KB)  PDF (502 KB)  ( 39 ) 122 Effect of Duhuo Jisheng Decoction on curative effect, inflammation level and traditional Chinese medicine syndrome score of patients with knee osteoarthritis ZHONG Xiaohui ZENG Weilin CHEN Chunsong HUANG Riqing WANG Guoyi Objective To analyze the effect of Duhuo Jisheng Decoction on the curative effect,inflammatory level and traditional Chinese medicine syndrome score of patients with knee osteoarthritis. Methods A total of 120 patients with knee osteoarthritis admitted to Zhangzhou Zhengxing Hospital from January 2016 to May 2020 were selected as the research subjects. They were divided into control group and experimental group by random number table method, with 60 cases in each group. Patients in control group were treated with Celecoxib Capsules, and patients in experimental group were treated with Duhuo Jisheng Decoction. The efficacy, interleukin-1 α (IL-1α), interleukin-6 (IL-6), tumor necrosis factor -α (TNF-α), traditional Chinese medicine syndrome score and knee function score were compared between the two groups. Results The total clinical effective rate of experimental group was 93.33%, which was higher than that of control group (80.0%), the difference was statistically significant (P<0.05). The levels of IL-1α, IL-6 and TNF-α in the two groups after treatment were lower than those before treatment, the differences were statistically significant (P<0.05). The levels of IL-1α, IL-6 and TNF-α in experimental group were lower than those in control group after treatment, the differences were statistically significant (P<0.05). The traditional Chinese medicine syndrome score and knee function score of the two groups after treatment were lower than those before treatment, the differences were statistically significant (P<0.05). The traditional Chinese medicine syndrome score and knee function score of the experimental group were lower than those of the control group after treatment, the differences were statistically significant(P<0.05). Conclusion Duhuo Jisheng Decoction can achieve significant clinical effect in the treatment of patients with knee osteoarthritis, significantly reduce the level of inflammation, improve the clinical symptoms and knee function,which is worthy of clinical promotion. 2022 Vol. 29 (13): 122-125 [Abstract] ( 28 ) HTML (1 KB)  PDF (493 KB)  ( 47 ) 126 Clinical effect of Wenjing Decoction combined with acupuncture and moxibustion in the treatment of patients with irregular menstruation JIN Zhidao Objective To investigate the clinical effect of Wenjing Decoction combined with acupuncture and moxibustion in the treatment of patients with irregular menstruation. Methods A total of 80 patients with irregular menstruation admitted to Wuhan Jiangxia District Maternal and Child Health Hospital from January 2018 to June 2020 were selected as the research subjects. They were divided into a control group and an observation group by ball-touching method,with 40 patients in each group. The patients in the control group were treated with hormone combined with acupuncture and moxibustion, and the patients in the observation group were treated with Wenjing Decoction on the basis of the control group. The therapeutic effect, traditional Chinese medicine syndrome score, endometrial thickness, estradiol (E2),and adverse reactions were compared between the two groups. Results The total effectiveness rate was 97.50% in the observation group, higher than that of the control group accounting for 80.00%, and the difference was statistically significant (P<0.05). After treatment, the menstrual cycle score, menstrual time score, menstrual volume score, and dysmenorrhea score in the observation group were lower than those in the control group, while E2 level and endometrial thickness were higher than those in the control group, and the differences were statistically significant (P<0.05). There was no significant difference in the total incidence of adverse reactions (P>0.05). Conclusion Combined with acupuncture and moxibustion, Wenjing Decoction has a significant effect on the treatment of irregular menstruation, and the menstrual cycle of patients can be restored, which is worthy of clinical application. 2022 Vol. 29 (13): 126-129 [Abstract] ( 33 ) HTML (1 KB)  PDF (489 KB)  ( 48 ) 130 Clinical application of soothing the liver in the treatment of anal pendant expansion ZHENG Xintao1 TANG Zhijun Anal pendant expansion is not a disease, but a clinical symptom in anorectal department, for its treatment plan, the treatment of traditional Chinese and Western medicine is mainly clinical experience, Western medicine mostly considers the treatment from the primary disease, while traditional Chinese medicine pays attention to syndrome differentiation and treatment. After the research of relevant Chinese medicine scholars, traditional Chinese medicine has unique curative effect in anal pendant expansion, but because the cause of anal pendant expansion is complicated and there is no systematic theoretical support, traditional Chinese medicine has different ideas in the treatment of anal pendant expansion. With the increasing number of patients with anal pendant expansion, the systematic diagnosis and treatment of patients with it is becoming more and more important. In long-term clinical observation, Professor Tang Zhijun found that most patients with different degrees abnormal emotion, or with other symptom from liver, for this reason, Professor Tang Zhijun found in the treatment of anal pendant expansion, the rational use of soothing the liver can achieve more ideal results. Based on the viewpoint and experience of Professor Tang Zhijun, this paper summarizes and expounds the clinical application of the method of relieving liver in the treatment of anal distension, aiming to provide data support for clinical application. 2022 Vol. 29 (13): 130-133 [Abstract] ( 31 ) HTML (1 KB)  PDF (486 KB)  ( 72 ) 134 Clinical effect of self-made Bushen Jianpi Antai Decoction in the treatment of threatened abortion with subclinical hypothyroidism LIANG Yan Objective To explore the clinical effect of self-made Bushen Jianpi Antai Decoction in the treatment of threatened abortion with subclinical hypothyroidism. Methods A total of 100 patients with threatened abortion combined with subclinical hypothyroidism in Maternal and Child Health Hospital of Jiangxi Province from August 2020 to March 2021 were selected as the research objects, and they were divided into the test group (50 cases) and the control group(50 cases) according to the random number table method. Both groups were treated with Progesterone Injection, the control group was treated with Levothyroxine Sodium Tablets, and the test group was treated with self-made Bushen Jianpi Antai Decoction on the basis of the control group. Both groups were treated for 30 days. The clinical efficacy after treatment and the levels of pregnancy hormone and thyroid function indexes before and after treatment were compared between the two groups. Results The total clinical effective rate after treatment in the test group was 88.00%,which was higher than 70.00% in the control group, the difference was statistically significant (P＜0.05). After treatment,the serum blood human chorionic gonadotropin (HCG), progesterone (P), estradiol (E2) levels in the two groups were higher than those before treatment, and the levels of HCG, P, E2 in the test group after treatment were higher than those in the control group, the differences were statistically significant (P＜0.05). The serum thyroid stimulating hormone(TSH) levels in the two groups after treatment were lower than those before treatment, and the level of TSH in the test group was lower than that in the control group, the differences were statistically significant (P＜0.05). There were no significant differences in the levels of serum free thyroxine (FT4) and free triiodothyronine (FT3) between the two groups before and after treatment (P＞0.05). Conclusion The self-made Bushen Jianpi Antai Decoction can adjust the thyroid function indexes and pregnancy hormone levels of patients with threatened abortion and subclinical hypothyroidism, enhance the therapeutic effect. 2022 Vol. 29 (13): 134-136转140 [Abstract] ( 27 ) HTML (1 KB)  PDF (490 KB)  ( 105 ) 137 Application effect of Sanlian Jinhuang Powder combined with red light therapy in the treatment of agkistrodon bites LIU Jiamiao YI Jiayou TAN Huifang Objective To explore the application effect of Sanlian Jinhuang Powder combined with red light therapy in the treatment of agkistrodon bites. Methods A total of 100 patients with agkistrodon bites who were admitted to Department of Surgery of Yichun Hospital of Traditional Chinese Medicine in Jiangxi Province from March 2020 to August 2021 were selected as the research subjects, and they were divided into the observation group (n=50) and the control group (n=50) according to random number table method. The control group was treated with conventional treatment, and the observation group was treated with Sanlian Jinhuang Powder combined with red light therapy on the basis of routine treatment. The swelling degree and pain index of the affected limbs of the two groups at different times were evaluated by limb circumference difference and visual analogue scale (VAS), and the length of hospital stay of the two groups was counted. Results Before treatment, there were no significant differences in the circumference of affected limb and VAS scores between the two groups (P＞0.05). At 1, 2, 3 and 6 days after treatment, the circumference of affected limb and VAS scores in the two groups were lower than those before treatment, and the circumference of affected limb and VAS scores in the two groups at 1, 2, 3 and 6 days after treatment were lower than those at the previous time point, and the differences were statistically significant (P＜0.05). The circumference of affected limb and VAS scores of the observation group at 2, 3 and 6 days after treatment were lower than those of the control group, with statistically significant differences (P＜0.05). The length of hospital stay of the observation group were shorter than those of the control group, with statistically significant differences (P＜0.05). Conclusion Sanlian Jinhuang Powder combined with red light therapy can significantly improve the therapeutic effect on agkistrodon bite, relieve swelling and pain of the affected limb, shorten hospital stay, it is worthy of clinical promotion. 2022 Vol. 29 (13): 137-140 [Abstract] ( 29 ) HTML (1 KB)  PDF (480 KB)  ( 76 ) 141 Effect of Zaoren Anshen Capsules combined with Estazolam in the treatment of persistent insomnia patients with heart-blood deficiency type LIU Yishan Objective To investigate the clinical efficacy of Zaoren Anshen Capsules combined with Estazolam in the treatment of persistent insomnia patients with heart and blood deficiency type. Methods The clinical data of 110 persistent insomnia patients with heart and blood deficiency type treated in Changsha Central Hospital from January 2018 to December 2020 were retrospectively selected, according to different treatment schemes, they were divided into the Western medicine group (n=50) and the combined group (n=60). The western medicine group was treated with Estazolam, and the combined group was treated with Zaoren Anshen Capsules combined with Estazolam. The changes of Pittsburgh sleep quality index score (PSQI), traditional Chinese medicine symptom scale scores and the levels of serum serotonin (5-HT) and γ-aminobutyric acid (GABA) were observed in the two groups, and the clinical efficacy and safety of the two groups were counted. Results The total clinical effective rate of the combined group was higher than that of the Western medicine group, and the difference was statistically significant (P＜0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P>0.05). After treatment, the PSQI total score, the scores of sleep onset time, sleep time, sleep quality and sleep efficiency of the combination group were lower than those of the Western medicine group, and the differences were statistically significant (P＜0.05). After treatment, the total score of traditional Chinese medicine symptom scale and the scores of dizziness and tinnitus, five upsets and heat, dry eyes and pale complexion in the combination group were lower than those in the Western medicine group, and the differences were statistically significant (P＜0.05). The serum 5-HT level in the combination group after treatment was higher than that in the Western medicine group, and the difference was statistically significant (P＜0.05). Conclusion Zaoren Anshen Capsules combined with Estazolam can improve the clinical efficacy of persistent insomnia patients with heart-blood deficiency type, effectively improve the symptoms of traditional Chinese medicine and sleep status, and increase the serum 5-HT content of patients, and no adverse reactions have been found so far. 2022 Vol. 29 (13): 141-144 [Abstract] ( 37 ) HTML (1 KB)  PDF (481 KB)  ( 21 ) 145 Analysis of the status quo and influencing factors of nurses′ knowledge,belief and practice in perioperative blood glucose management YU Yi Objective To explore the current situation and influencing factors of surgical nurses′ knowledge, belief and practice in perioperative blood glucose management. Methods From March 2017 to April 2020, 45 in-service surgical nurses in People′s Hospital of Pingxiang City were selected to conduct a questionnaire survey to understand the status quo of surgical nurses′ knowledge, belief and practice in perioperative vascular management, and analyze the factors affecting the status quo of knowledge, belief and practice. Results Among 45 in-service surgical nurses, 31 cases(68.89%) had good knowledge and practice status, while 14 cases (31.11%) had bad knowledge and practice status. The results of single factor analysis showed that there was statistically significant difference in the score of nurses with different education level, job title, professional title, working years and relevant training times (P＜0.05). Logistic regression analysis showed that education level was low (β=0.065, OR=1.066, 95%CI=0.365-2.162), job level was low (β=0.145, OR=1.331, 95%CI=0.475-3.174), professional title level was low (β=0.211, OR=1.547, 95%CI=0.875-3.406),working years ＜3 years (β=1.412, OR=2.997, 95%CI=1.522-5.914), related training times ＜2 times (β=0.623, OR=2.866, 95%CI=0.767-4.878) were risk factors for poor knowledge, belief and practice status (P＜0.05). Conclusion Surgical nurses′ knowledge, belief and practice in perioperative blood glucose management are good, but still need to be strengthened. Education level, position, professional title, working years and training times have an impact on the status of knowledge, belief and practice, which can be further optimized and improved on this basis. 2022 Vol. 29 (13): 145-148 [Abstract] ( 29 ) HTML (1 KB)  PDF (458 KB)  ( 30 ) 149 Current status and influencing factors of migration stress in family members of patients with cerebral hemorrhage transferred from neurosurgical intensive care unit YAN Xiaofeng YIN Xinhong▲ TAN Xiuzhu FENG Jing Objective To investigate the status and influencing factors of migration stress in family members of patients with cerebral hemorrhage transferred from neurosurgical intensive care unit(NSICU). Methods A total of 97 family members of NSICU patients with intracerebral hemorrhage who were admitted to the First Affiliated Hospital of Nanhua University from December 2020 to June 2021 were selected as research subjects. The status and influencing factors of migration stress in family members of NSICU patients with intracerebral hemorrhage were analyzed by general data questionnaire and migration stress scale of family members of patients transferred from intensive care unit (ICU). Results The total migration stress score of NSICU transferred cerebral hemorrhage patients′ families was (46.10±4.50) points.The average score of the three dimensions from high to low was the recognition of treatment conditions and environmental changes ([2.80±0.29] points), anxiety of ICU transfer ([2.73±0.44] points), and knowledge of patients′ condition([2.64±0.39] points). Univariate analysis results showed that there was statistically significant difference in the migration stress scores of family members of patients with different gender, patient consciousness and total ICU treatment duration (P<0.05). Multiple liner regression analysis showed that gender of family members (X1), patient consciousness (X2)and ICU treatment duration (X3) were independent risk factors for migration stress of family members (P<0.05).Equation was Y=37.797+2.294 (X1)+0.676 (X2)+1.449(X3). Conclusion There is a moderate level of migration stress in the family members of patients with cerebral hemorrhage transferred from the neurosurgical care unit,which is related to the gender of the family members, the consciousness state of the patients and the total treatment time in ICU. 2022 Vol. 29 (13): 149-152转156 [Abstract] ( 28 ) HTML (1 KB)  PDF (515 KB)  ( 99 ) 153 Investigation and analysis of blood donor satisfaction in Zhuhai Central Blood Station SONG Liuqing1 LAN Zhu2 HAO Siwen Objective To understand the current situation of blood donor satisfaction in Zhuhai Central Blood Station,and to provide reference for improving the overall service quality. Methods A total of 2813 blood donors who donated blood without compensation in Zhuhai Central Blood Station from January to November 2020 were selected as the research objects. A self-made satisfaction questionnaire was used to investigate the satisfaction of blood donors with telephone survey by the Quality Management Office of Zhuhai Central Blood Station, and their satisfaction was recorded and analyzed. Results The overall satisfaction rate of 2813 blood donors was 99.93%, among which the satisfaction rate of clothing and blood donation environment was 100.00%. The unsatisfied blood donors were mainly those with high school education or above, those who were employed and those who had donated blood once. Among 2813 blood donors,a total of 72 gave specific suggestions or opinions, mainly regarding blood donation services. Conclusion Blood donors to higher overall satisfaction of Zhuhai Central Blood Station, when there is a large blood but long waiting time, poor environmental management and some of the blood donation nurse puncture technique to improve the deficiencies, such as blood stations in pursuance of management should be strengthened and the nurse training, constantly improve the management level and puncture level, in order to improve the overall quality of service. 2022 Vol. 29 (13): 153-156 [Abstract] ( 29 ) HTML (1 KB)  PDF (483 KB)  ( 38 ) 157 One case of acute traumatic synovitis treated by Chengjiang school acupuncture SONG Sitao1 TIAN Fengwei2 ZHANG Guifang Acute traumatic synovitis of knee joint is caused by acute joint trauma, which leads to knee pain, swelling and limited activity. It is a common disease in clinical acupuncture treatment. However, modern medical therapy is limited in the treatment of the disease, and surgical therapy for patients with severe illness has long recovery time and many complications, which is not conducive to the rehabilitation of the disease. Traditional acupuncture treatment for acute knee disease curative effect, with "simple, convenient, inexpensive, effective" characteristics. The acupuncture method of Chengjiang School is based on the theoretical system of traditional medicine and modern anatomical structure of human body. It combines the traditional hexagram orientation and structure of muscle ligament of knee joint. On the basis of accurate positioning of diseased muscle ligaments, it can achieve better curative effect by traditional acupuncture reinforcing and reducing manipulation, combined with electro-acupuncture and the specific electromagnetic spectrum. This paper reports one case of acute traumatic synovitis treated by acupuncture and moxibustion in Chengjiang School. The treatment method can be used for reference in clinical practice. 2022 Vol. 29 (13): 157-160 [Abstract] ( 27 ) HTML (1 KB)  PDF (549 KB)  ( 23 ) 161 A case of primary liver cancer after donor kidney transplantation from an HBV-carrying donor and literature review LIN Yiru LIU Linlin DING Guofeng This article retrospectively analyzes the diagnosis and treatment of a patient who received a hepatitis B virus-bearing donor kidney organ transplant 10 years after concomitant hepatocellular carcinoma with multiple intrahepatic metastases. This patient received a donor kidney from a patient with hepatitis B in 2010 due to "renal failure". The procedure went well, intraoperative blood transfusion is unknown, and recovery was fair. The patient took anti-rejection drugs regularly after transplantation, but did not take antiviral treatment regularly, nor did he have regular follow-ups for alpha fetal protein (AFP), hepatitis B virus DNA (HBV-DNA) quantification, and liver imaging,etc. He was diagnosed with hepatocellular carcinoma and multiple metastases in the liver in October 2019 and died in March 2020. The purpose of this study was to investigate the necessity of regular antiviral therapy and regular followup of liver-related functions after receiving hepatitis B virus-infected donor organ transplantation, and for patients who are eligible, antiviral therapy should be administered before transplantation, thus reducing the occurrence of malignant tumors after hepatitis B virus-related organ transplantation, and thus improving the efficiency of donor organ use and reducing mortality. 2022 Vol. 29 (13): 161-163转168 [Abstract] ( 25 ) HTML (1 KB)  PDF (525 KB)  ( 38 ) 164 A case of optimal management of heart failure in primary heart failure center CHEN Ling SHEN Li′na ZHANG Zhenzhen XU Jiayi Chronic heart failure (CHF) is a serious manifestation and late stage of various heart diseases with high mortality and re-hospitalization rate. Since 2017, China Cardiovascular Health Alliance has initiated the construction and certification project of China Heart Failure Center, leading hospitals at all levels in China to carry out standardized diagnosis, treatment and management of this disease. Since the establishment of the primary heart failure Center in 2019, the Department of Cardiology of Shanghai Ruijin Rehabilitation Hospital has received whole-course guidance from the Heart failure Demonstration Center, professional medical training and optimized management of patients inside and outside the hospital. The two sides work together to achieve precise treatment and manage heart failure patients in the region. This report presents a case of a 57-year-old male patient who is corpulent and has reduced ejection fraction. After two years of clinic follow-up and medication optimum at the primary heart failure center. The structural abnormalities of his heart were ameliorated, the left ventricular ejection fraction has increased. Blood sugar, weight, and abdominal circumference tend to be normal, the risk of hospitalization and death is reduced, and improves his life quality and ability to function. 2022 Vol. 29 (13): 164-168 [Abstract] ( 28 ) HTML (1 KB)  PDF (570 KB)  ( 61 ) 169 Effect of situational communication intervention combined with dual track interactive nursing on emotional symptoms and quality of life in young patients with bipolar disorder ZHAN Lijuan Objective To analyze the effect of situational communication intervention combined with dual track interactive nursing on the emotional symptoms and quality of life in young patients with bipolar disorder. Methods A total of 80 patients with bipolar disorder admitted to the Third People′s Hospital of Shangrao City from January 2018 to January 2021 were selected as the research subjects, and they were divided into experimental group (n=40) and control group (n=40) according to the random number table method. The control group was given dual track interactive nursing intervention, while the experimental group combined with situational communication intervention on the basis of the control group. The depression score, anxiety score and score of ability of daily living before and after intervention were compared between the two groups. Results After intervention, the scores of depression and anxiety in experimental group were lower than those in control group, the differences were statistically significant (P<0.05). After intervention,the score of ability of daily living impairment in experimental group was lower than that in control group, the difference was statistically significant (P<0.05). Conclusion Situational communication intervention combined with dual track interactive nursing for young patients with bipolar disorder can effectively relieve the anxiety and depression, improve the psychological health status, enhance the ability of daily living, and further improve the quality of life of patients. 2022 Vol. 29 (13): 169-171 [Abstract] ( 35 ) HTML (1 KB)  PDF (633 KB)  ( 43 ) 172 Effect of targeted nursing intervention in preventing postoperative urinary retention of cervical cancer LIU Xi Objective To explore the clinical effect of targeted nursing intervention in preventing postoperative urinary retention of cervical cancer. Methods A total of 120 patients with urinary retention after radical hysterectomy for cervical cancer in Pingxiang Maternal and Child Health Hospital from August 2018 to April 2021 were divided into two groups according to random number table method, with 60 cases in each group. The control group was given routine nursing after operation, the observation group was given targeted nursing on the basis of routine nursing intervention.The changes of urinary discomfort symptom scores, bladder compliance and bladder maximum detrusor pressure in urodynamic indexes before and after intervention were compared between the two groups, and the time of indwelling catheter, urine volume and residual urine volume 24 h after catheter removal were counted between the two groups.Results After the intervention, the scores of urinary discomfort symptoms in the two groups were lower than those before the intervention, and the scores of urinary discomfort symptoms in the observation group were lower than those in the control group, the differences were statistically significant (P<0.05). After the intervention, the compliance and the maximum detrusor pressure in the bladder of the observation group were higher than those in the control group, the differences was statistically significant (P<0.05). The indwelling catheterization time in the observation group was shorter than that in the control group, the difference was statistically significant (P<0.05). The urine volume in 24 h after catheter removal was larger than that in the control group,the difference was statistically significant(P<0.05).Conclusion Targeted nursing can effectively improve urinary discomfort,improve bladder physiological function,shorten postoperative indwelling catheterization time and promote early recovery of urinary physiological function in patients with cervical cancer after operation. 2022 Vol. 29 (13): 172-174转182 [Abstract] ( 28 ) HTML (1 KB)  PDF (625 KB)  ( 62 ) 175 Effect of regional prevention and treatment based on nurse-led doctorpatient participation in early warning and management of venous thromboembolism YOU Yanyan Objective To analyze the application effect of regional prevention and treatment based on nurse-led doctor-patient participation in early warning and management of venous thromboembolism. Methods A total of 66 inpatients admitted to Foshan Nanhai People′s Hospital from March 2018 to July 2019 were selected as the routine group, and 66 inpatients admitted to Foshan Nanhai People′s Hospital from August 2019 to December 2020 were selected as the research group. The routine group received routine nursing intervention. The team adopted a regional approach based on nurse-led doctor-patient participation on a routine basis. The incidence of deep vein thrombosis and pulmonary vein thrombosis was compared between the two groups. D-dimer (D-D) level and hemorheology (plasma viscosity [PV], fibrinogen [FIB]) were compared between the two groups before and after intervention. The knowledge of disease was compared between the two groups before and after intervention. Results The incidence rate of deep vein thrombosis (3.03%, 2/66) and the incidence rate of pulmonary vein thrombosis (3.03%, 2/66) in the study group, were both lower than 12.12% (8/66) and 13.64% (9/66) in the conventional group, the differences were statistically significant(P<0.05). After intervention, the D-D level of the study group was lower than that of the conventional group, and the difference was statistically significant (P<0.05). After intervention, PV and FIB levels in the study group were lower than those in the conventional group, the differences were statistically significant (P<0.05). After intervention, the disease knowledge mastery score in the study group was higher than that in the conventional group, and the difference was statistically significant (P<0.05). Conclusion The regional prevention and treatment based on nurse-led doctorpatient participation can improve the knowledge of the disease, improve blood hypercoagulability, promote blood circulation,reduce the incidence of venous thromboembolism in the early warning management of venous thromboembolism,and has high clinical promotion value. 2022 Vol. 29 (13): 175-178转186 [Abstract] ( 28 ) HTML (1 KB)  PDF (1073 KB)  ( 104 ) 179 Application effect of optimized anesthesia care in patients undergoing cardiac surgery WEN Yi Objective To explore the effect of optimized anesthesia care on anesthesia quality of cardiac surgery patients. Methods A total of 506 cardiac surgery patients who were admitted to Shenzhen People′s Hospital, the Second Clinical Medical College of Ji′nan University from February 2020 to October 2021 were selected as the study subjects,and they were divided into the reference group (n=253) and the optimization group (n=253) by the random number table method. Intubation and venous recombination were performed in both groups after general anesthesia. Patients in the reference group were given conventional anesthesia care, and patients in the optimization group were given optimized anesthesia care. The excellent and good rate of clinical anesthesia effect, time required for tracheal intubation, anesthesia quality score, incidence of adverse reactions and satisfaction rate of anesthesia care were compared between the two groups. Results The excellent and good rate of clinical anesthesia effect in the optimization group (98.92%) was higher than that in the reference group (96.05%), the difference was statistically significant (P<0.05). The anesthesia quality score in the optimization group ([95.15±3.04] points) was higher than that in the reference group ([95.15±3.04] points),and the difference was statistically significant (P<0.05). The total satisfaction rate of anesthesia nursing in the optimization group (98.81%) was higher than that in the reference group (95.26%), the difference was statistically significant(P<0.05). The time required for tracheal intubation in the optimization group ([14.58±2.32] min) was shorter than that in the reference group ([21.62±4.35] min), and the difference was statistically significant (P<0.05). The overall incidence of adr in the optimization group (0.78%) was lower than that in the reference group (4.75%), and the difference was statistically significant (P<0.05). Conclusion After receiving the optimized anesthesia care, cardiac surgery patients can get better anesthesia effect, improve the quality of anesthesia, and reduce the rate of adverse reactions to anesthesia,and the satisfaction rate of anesthesia care is higher. 2022 Vol. 29 (13): 179-182 [Abstract] ( 30 ) HTML (1 KB)  PDF (646 KB)  ( 97 ) 183 Application of health education in patients with chronic kidney disease XIA Pingyuan ZOU Huiqin WANG Li PENG Hongyun ZHU Aijun CHAI Jiangchen Objective To analyze the application of health education in patients with chronic kidney disease. Methods A total of 80 patients with chronic kidney disease who were treated in Huazhong University of Science and Technology Union Shenzhen Hospital from June 2019 to June 2020 were selected as the research subjects. They were divided into experimental group and control group with 40 cases in each group by random number table method. Patients in the control group received routine nursing interventions, and patients in the experimental group received comprehensive health education measures on the basis of routine nursing. The medical advice compliance rate, index control rate, selfmanagement score and nursing satisfaction rate of patients in the two groups were compared. Results The doctor′s order compliance rate and index control rate of the experimental group were higher than those of the control group, the differences were statistically significant (P<0.05). After intervention, the health behavior, health status, disease cognition,the quality of life, self-efficacy scores of the two groups were higher than those before the intervention, the differences were statistically significant (P<0.05). After intervention, the health behavior, health status, disease cognition, the quality of life, self-efficacy scores of the experimental group were higher than those of the control group, the differences were statistically significant (P<0.05). The total satisfaction rate of nursing in experimental group was higher than that in control group, and the difference was statistically significant (P<0.05). Conclusion Proper health education and nursing intervention for patients with chronic kidney disease can significantly improve their quality of life, so health education should be promoted and applied as a necessary nursing content for patients with chronic kidney disease. 2022 Vol. 29 (13): 183-186 [Abstract] ( 28 ) HTML (1 KB)  PDF (613 KB)  ( 101 ) 187 Application value of predictive nursing in the safe transportation of ICU patients in hospital HUANG Bozhang Objective To explore the application value of predictive care in the safe transportation of ICU patients in the hospital. Methods A total of 86 patients in the ICU of First People′s Hospital of Zhaoqing from January to June 2021 were selected as the study group, and 80 patients in the ICU of First People′s Hospital of Zhaoqing from July to December 2020 were selected as the control group. Routine nursing was used in the control group and predictive nursing was used in the study group. The total incidence of adverse events, average hospital transit time and nursing satisfaction were compared between the two groups. Results The total incidence of adverse events in the study group was lower than that in the control group, and the difference was statistically significant (P<0.05). The average transit time in the study group was shorter than that of the control group, and the difference was statistically significant (P<0.05). The nursing satisfaction of the study group was higher than that of the control group, and the difference was statistically significant (P<0.05). Conclusion The use of predictive nursing during the in-hospital transfer of ICU patients can further reduce the incidence of adverse events, shorten the average in-hospital transfer time, and provide safety guarantees for patients while improving the transfer efficiency. 2022 Vol. 29 (13): 187-189 [Abstract] ( 30 ) HTML (1 KB)  PDF (612 KB)  ( 21 ) 190 Application value of retrospective outcome special attention nursing in preventing deep venous thrombosis in bedridden patients in intensive care unit CAO Huilian Objective To explore the application value of retrospective outcome special attention nursing in preventing lower extremity deep venous thrombosis (DVT) in bedridden patients in intensive care unit (ICU). Methods A total of 70 patients admitted to ICU of the Second Affiliated Hospital of Gannan Medical College from January to December 2020 were selected as the research subjects. They were divided into control group and observation group by random number table method, with 35 patients in each group. The control group received routine nursing, and the observation group received retrospective special attention nursing. The incidence of DVT, risk assessment of DVT and nursing satisfaction were compared between the two groups. Results The incidence of DVT in the observation group was lower than that in the control group during the nursing period, the difference was statistically significant (P<0.05). After nursing, the risk level of DVT in the two groups were lower than those before nursing, the differences were statistically significant (P<0.05). After nursing, the risk grade of DVT in observation group was lower than that in control group, the difference was statistically significant (P<0.05). The total nursing satisfaction rate of the observation group was higher than that of the control group, and the difference was statistically significant (P<0.05). Conclusion In the nursing of bedridden patients in ICU, retrospective outcome special attention nursing can better prevent DVT, reduce the risk of DVT, and improve nursing satisfaction. 2022 Vol. 29 (13): 190-192转196 [Abstract] ( 28 ) HTML (1 KB)  PDF (624 KB)  ( 32 ) 193 Application effect of integrated traditional Chinese and Western medicine nursing in patients with cerebral stroke complicated with pulmonary infection HAN Yun1 WEN Jin Objective To explore the application effect of integrated traditional Chinese and Western medicine nursing in patients with cerebral stroke complicated with pulmonary infection. Methods A total of 76 patients with cerebral stroke complicated with pulmonary infection in the Mentougou Hospital of Traditional Chinese Medicine in Beijing from August 2018 to January 2021 were selected as the research subjects and divided into the observation group and the control group by the random number table method, with 38 cases in each group. Patients in the observation group received integrated traditional Chinese and Western medicine nursing, while patients in the control group received conventional nursing. Life quality scores, modified Barthel index and prognosis were compared between the two groups.Results There was no significant difference in quality of life score between the two groups before nursing (P>0.05). The quality of life scores of the two groups after nursing were higher than those before nursing, and the quality of life score of the observation group after nursing was higher than that of the control group, the differences were statistically significant (P＜0.05). There was no significant difference in the Barthel index between the two groups before nursing (P>0.05).After nursing, the Barthel indexes of the two groups were higher than those before nursing, and the Barthel index of the observation group was higher than that of the control group, the differences were statistically significant (P＜0.05). The total effective rate of observation group was higher than that in the control group, and the difference was statistically significant (P＜0.05). Conclusion The total effectiveness rate of integrated Chinese and Western medicine nursing intervention in patients with cerebral stroke complicated with pulmonary infection is higher, which can significantly improve the prognosis of patients with cerebral stroke complicated with pulmonary infection and improve the life quality of patients, and is worthy of clinical promotion. 2022 Vol. 29 (13): 193-196 [Abstract] ( 23 ) HTML (1 KB)  PDF (642 KB)  ( 50 )

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