碳酸镧咀嚼片联合帕立骨化醇对维持性血液透析患者血清钙、磷及骨密度的影响

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Abstract Objective To investigate the influence of Lanthanum Carbonate Chewable Tablets combined with Paricalcitol on serum calcium, phosphorus and bone mineral density in patients with maintenance hemodialysis (MHD). Methods A total of 90 patients with MHD confirmed from May 2020 to May 2021 in Ganzhou Municipal Hospital were enrolled. They were divided into group A (30 cases), group B (30 cases) and group C (30 cases) by random number table method. Group A was given Lanthanum Carbonate Chewable Tables, group B was given Paricalcitol, and group C was given Lanthanum Carbonate Chewable Tables combined with Paricalcitol. All patients were continuously treated for 1 months. The score of kidney disease quality of life short form (KDQOL-SF), left hip joint bone mineral density (BMD),triceps skin fold thickness (TSF), mid-arm muscle circumference (MAC), calcium and phosphorus metabolism indexes,nutritional indexes and the total incidence of adverse reactions were compared among three groups before and after treatment. Results After treatment, the KDQOL-SF scores and BMD in group C were higher than those in group A and group B, and which were higher than those before treatment, the differences were statistically significant (P＜0.05).There were no significant differences in the KDQOL-SF scores and BMD between group A and group B before and after treatment (P＞0.05). After treatment, TSF and MAC in group C were greater than those in group A and group B, and which were larger than those before treatment, the differences were statistically significant (P＜0.05). There were no significant differences in TSF and MAC between group A and group B before and after treatment (P＞0.05). After treatment, there was no statistically significant difference in blood calcium levels between the three groups and before and after treatment (P＞0.05). After treatment, blood phosphorus in group C was lower than that before treatment, and which were lower than those in group A and group B, the differences were statistically significant (P＜0.05). The creatinine level in group C after treatment was lower than that in group A and group B, the albumin level in group C after treatment was higher than that in group A and group B, and the creatinine levels in the three groups after treaatment were lwer than those before treatment, the albumin levels in the three groups after treatment were higher than those before treatment, the differences were statistically significant (P＜0.05). There were no significant difference in the total incidence of adverse reactions among the three groups (P＞0.05). Conclusion The Lanthanum Carbonate Chewable Tablets combined with Paricalcitol can effectively improve the levels of serum phosphorus, BMD, and can effectively improve nutritional status and quality of life in patients undergoing MHD.

Key words： Lanthanum Carbonate Chewable Tablet Paricalcitol Serum calcium and phosphorus Bone mineral density Maintenance hemodialysis

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