基于数据挖掘法分析具有降血脂功能保健食品组方的用药规律

Abstract
Figure/Table
References (29)
Related Citation (15)

Download: PDF (951 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective Based on data mining method, this paper discusses the medication rule of health food prescription with hypolipidemic function. Methods Taking the compound health food for reducing blood lipid collected by state administration for market regulationas the data source, Microsoft Excel 2019 was used to analyze the data in terms of dosage form, health care function, efficacy classification and medication frequency. Describe the nature, taste and meridian tropism of high-frequency Chinese medicine (frequency ≥15). SPSS Statistic 20.0 and SPSS Modeler 15.0 were used to analyze the systematic clustering and association rules of high-frequency traditional Chinese medicine.Results A total of 343 prescriptions met the requirements, among which the capsule (260 prescriptions) accounted for 75.80%. The number of health foods with one and two health functions was 251 and 92, respectively. A total of 103 traditional Chinese medicines, such as tonifying deficiency, antitussive antiasthmatic, relieving exterior syndrome and promoting blood circulation and removing blood stasis were used frequently. There were 15 kinds of high-frequency traditional Chinese medicines, which were mainly sweet, mostly mild and cold, and mainly belong to liver, spleen and lung meridians. Eight drug combinations were obtained by further cluster analysis, and the association rule analysis showed that Gynostemma pentaphyllum, Pueraria lobata, Salvia miltiorrhiza, Ginkgo biloba and Hawthorn were highly correlated. Conclusion The formula of health food with the function of lowering blood lipids is mainly composed of tonifying deficiency and invigorating spleen to treat its origin, promoting blood circulation, invigorating dampness and resolving phlegm to treat its standard. It is basically consistent with the theory of reducing blood lipids of traditional Chinese medicine, that is, strengthening body resistance, eliminating phlegm, removing blood stasis and removing dampness.

Key words： Hyperlipidemia Heath food Medication laws Association rules Cluster analysis

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors

Cite this article:

URL:

https://www.dangdaiyiyao.com/EN/ OR https://www.dangdaiyiyao.com/EN/Y2022/V29/I13/14

[1]	Kopin L，Lowenstein C.Dyslipidemia[J].Ann Intern Med，2017，167（11）：81-96.
[2]	Song DX，Jiang JG.Hypolipidemic Components from Medicine Food Homology Species Used in China：Pharmacological and Health Effects[J].Arch Med Res，2017，48（7）：569-581.
[3]	荣春蕾，刘文娟，管鸽，等.基于关联规则的中药治疗高脂血症用药规律分析[J].中国合理用药探索，2021，18（10）：45-50.
[4]	赵旺，叶平，胡大一，等.根据《中国成人血脂异常防治指南（2016年修订版）》再分析DYSIS-China 横断面调查[J].中国心血管杂志，2020，25（1）：55-61.
[5]	Kloska A，Malinowska M，Gabig-Cimińska M，et al.Lipids and Lipid Mediators Associated with the Risk and Pathology of Ischemic Stroke[J].Int J Mol Sci，2020，21（10）：3618.
[6]	耿秀超，张雨豪，王梓，等.基于数据挖掘和网络药理学的血脂异常用药规律和作用机制研究[J].世界科学技术-中医药现代化，2021，23（4）：1096-1107.
[7]	Huang F，Zheng X，Ma X，et al.Theabrownin from Puerh tea attenuates hypercholesterolemia via modulation of gut microbiota and bile acid metabolism[J].Nat Commun，2019， 10（1）：4971.
[8]	卓冰帆，张彦卿，张敏.山荷降脂汤治疗痰湿内阻型高脂血症合并脂肪肝的临床研究[J].时珍国医国药，2019，30（6）：1426-1428.
[9]	张桐，马晓燕，秦梦，等.一种辅助降脂保健食品功能性及机制研究[J].食品研究与开发，2019，40（10）：13-19.
[10]	赵新，张林旭，路雪婧.基于数据挖掘预防新型冠状病毒肺炎中医方药初探[J].中草药，2020，51（5）：1147-1152.
[11]	高嵩，高月娟，朱仁英，等.数据挖掘技术在药品不良反应监测中的应用进展[J].中国当代医药，2021，28（26）：31-35.
[12]	吴琼，何宇霞，花卉，等.基于数据挖掘分析辅助降血糖中药保健食品组方规律及特点[J].食品安全质量检测学报，2021，12（6）：2385-2393.
[13]	国家药典委员会.中华人民共和国药典[M].北京：中国医药科技出版社，2020.
[14]	国家中医药管理局中华本草编委会.中华本草[M].上海：上海科学技术出版社，1999.
[15]	管咏梅，姜鄂，朱卫丰，等.葛根在保健食品中的应用规律分析[J].中国实验方剂学杂志，2019，25（4）：212-217.
[16]	王艳宏，樊建，李洪晶，等.丹参相关保健食品的应用情况分析[J].中国实验方剂学杂志，2020（6）：168-177.
[17]	钟赣生.中药学[M].4 版.北京：中国中医药出版社，2016.
[18]	周佳，陈娇，韦双双.从脾论治高脂血症[J].长春中医药大学学报，2016，32（2）：309-312.
[19]	马浩玲，张德芹，丁丽琴，等.治疗高脂血症上市中成药的处方规律研究[J].天津中医药大学学报，2018（6）：506-510.
[20]	许麦成，程新梅，马吕丽.银杏叶提取物调节高脂血症大鼠模型血脂的有效剂量研究[J].中草药，2021，52（2）：454-458.
[21]	Dehghani S，Mehri S，Hosseinzadeh H.The effects of Crataegus pinnatifida （Chinese hawthorn）on metabolic syndrome：A review[J].Iran J Basic Med Sci，2019，22（5）：460-468.
[22]	邓楠，余胜，刘文，等.决明子调脂作用的代谢组学研究[J].中国现代医学杂志，2016，26（8）：7-10.
[23]	Li S，Jin S，Song C，et al.The metabolic change of serum ly-sophosphatidylcholines involved in the lipid lowering effect of triterpenes from Alismatis Rhizoma on high-fat diet induced hyperlipidemia mice[J].J Ethnopharmacol，2016，177（11）：10-18.
[24]	刘晓燕，崔亚东，田合禄.中医四气五味理论与脏腑补泻关系的探讨[J].世界中医药，2021，16（1）：121-124，129.
[25]	刘宗莲，杨凤珍，王秋风.国医大师路志正调理脾胃治疗高脂血症经验[J].中华中医药杂志，2017，32（9）：4012-4014.
[26]	郑榕昌，谢梦洲，王行宽.王行宽教授辨病论治高脂血症经验总结[J].中国中医药现代远程教育，2019，17（13）：57-59.
[27]	钟礼云，林蔚，李杨锦，等.绞股蓝葛根丹参提取物对大鼠降血脂作用的研究[J].海峡预防医学杂志，2019，25（5）：70-71.
[28]	Larsen LE，Smith MA，Abbey D，et al.Hepatocyte-like cells derived from induced pluripotent stem cells：A versatile tool to understand lipid disorders[J].Atherosclerosis，2020，303：8-14.
[29]	闫辉，赵杰，刘影，等.北京市儿童保健人员对儿童青少年血脂异常发生率的认知情况及检查意愿的调查研究[J].中国全科医学，2021，24（17）：2202-2206.