丁苯酞软胶囊治疗急性缺血性脑卒中的临床效果及对患者中性粒细胞-淋巴细胞比值、白细胞介素-33的影响

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Abstract Objective To investigate the curative effect of Butylphthalide Soft Capsules in the treatment of acute ischemic stroke and its influence on neutrophil to lymphocyte ratio (NLR) and interleukin-33 (IL-33). Methods A total of 130 patients with acute ischemic stroke admitted to the Department of Neurology of the 73rd Army Hospital of the Army from July 1,2020 to June 30,2021 were selected as the study subjects.They were divided into study group(65 cases) and control group (65 cases) by random number table method. The control group was given conventional treatment,and the study group was combined with Butylphthalide Soft Capsules. The improvement of neurological impairment and the ability of daily living were compared between the two groups before and after treatment, and the levels of neutrophil(N), lymphocyte (L), NLR and IL-33 were compared between the two groups before and after treatment. Results After treatment, the scores of National Institutes of Health stroke scale (NIHSS) in the two groups were lower than those before treatment, the Barthel indexes in the two groups were higher than those before treatment, and the NIHSS score in study group was lower than that in the control group, the Barthel index in study group was higher than that in the control group (P<0.05). After treatment, N and NLR levels in the two groups were lower than those before treatment, while L levels in the two groups were higher than those before treatment, and N and NLR levels in study group were lower than those in the control group, while L level in study group was higher than that in the control group (P<0.05). After treatment, the levels of IL-33 in the two groups were higher than those before treatment, and the level of IL-33 in study group was higher than that in the control group (P<0.05). Conclusion Butylphthalide Soft Capsules has a significant clinical effect on patients with acute ischemic stroke, which can reduce NLR and increase IL-33 level, and has a positive effect on improving the prognosis of patients, which is worthy of promotion.

Key words： Butylphthalide Soft Capsules Acute ischemic stroke Clinical efficacy Neutrophil to lymphocyte ratio Interleukin-33

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