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2019 Vol. 26, No. 6
Published: 2019-02-28
4
Optimization study on conditions for the measurement of polyphenol content in Pomegranate Peel by Folin-Ciocalteu colorimetry
SONG Zhen-guo WU Xiao-yu YAN Lin MA Ming CHENG Qin-yuan
Objective
To screen and determine the optimal conditions for measurement of polyphenol content in Pomegranate Peel extracts by Folin-Ciocalteu colorimetry.
Methods
In this study，Gallic Acid was selected as the standard substance.After determining the wavelength of measurement，the effects of Folin-Ciocalteu（FC）reagent concentration，Na
2
CO
3
reagent concentration，reaction time and reaction temperature were investigated systematically，and the methodology was also investigated.
Results
It was showed that the optimum conditions for the measurement of polyphenols in Pomegranate Peel extracts were：1 ml sample solution，5 ml 40%FC reagent，4 ml 10%Na
2
CO
3
reagent and protected from light at 20℃for 100 min.The polyphenol content had a good linear relationship with the absorbance at 750 nm.The average recovery rate of this method was 99.51%，and the RSD was 2.56%.The polyphenol content in the Pomegranate leaf sample was determined to be （142.42±5.88）mg/g by the optimized method.
Conclusion
The optimized folin-ciocalteu colorimetric method is convenient and stable，and is reliable to measure polyphenol content in Pomegranate Peel extracts.
2019 Vol. 26 (6): 4-7 [
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109
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Meta analysis of the effect of comprehensive geriatric assessment nursing intervention model on the intervention of elderly inpatients with coronary heart disease in China
GUO Jin-huaYANG Dan ZHANG Jun
Objective
To systematically evaluate the effect of comprehensive geriatric assessment nursing intervention model on the elderly inpatients with coronary heart disease in China.Methods Relevant literatures of common medical database at home and abroad such as CHKI，Wanfang，Weipu，PubMed and CINAHL etc.were searched，and the search date was from database construction to May 2018.Documents were selected according to certain inclusion criteria and exclusion criteria and Meta analysis was performed using Review Manager 5.3 statistical software.
Results
A total of 17 articles were included which contained 1873 elderly inpatients with coronary heart disease.Meta analysis results showed that，the scores of life quality of hospitalized elderly patients with coronary heart disease who were given the comprehensive geriatric assessment nursing intervention were significantly higher than those of the implementation of cardiology routine nursing care，and the differences were statistically significant（MD=14.54，95%CI ［13.60-15.48］，P＜0.00001）.The incidence rate of adverse events of hospitalized elderly patients with coronary heart disease who were given the comprehensive geriatric assessment nursing intervention was significantly lower than that of the implementation of cardiology routine nursing care，and the differences were statistically significant（relative risk ［RR］=0.39，95%CI［0.29-0.52］，P＜0.00001）.The hospital stay of hospitalized elderly patients with coronary heart disease who were given the comprehensive geriatric assessment nursing intervention was significantly shorter than that of the implementation of cardiology routine nursing care，and the differences were statistically significant（MD=-4.26，95%CI ［-4.94--3.59］，P＜0.00001）.
Conclusion
The comprehensive geriatric assessment nursing intervention model can improve the medical service effect of hospitalized elderly patients with coronary heart disease and save medical and health resources.
2019 Vol. 26 (6): 8-11 [
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12
Epidemiological analysis and prevention strategies of hospitalized children with burns in a third-grade class-A hospital in Yinchuan city
XUE Xi-juan1MA Hui-zhen2YAO Miao2LIU Xiao-hui
Objective
To summarize the epidemiological characteristics of hospitalized children with burns in Ningxia，analyze the main causes of children′s burns and their influencing factors，and formulate the prevention strategies for children with burns.
Methods
A retrospective survey was conducted to analyze the medical records of hospitalized children with burns in a third-grade class-A hospital from January 2011 to December 2017 in Yinchuan city of Ningxia.
Results
There were a total of 2551 hospitalized children with burns from 2011 to 2017，including 1548 males and 1003 females.The male to female ratio was about 1.54 to 1.83.9%children were≤3 years old，8.3%were between＞3 and 6 years old，and 7.8%were between ＞6 and 14 years old.Hydrothermal burns accounted for 86.5%of the total burns，and flame burns accounted for 6.6%.Burn rate was 29.1%in summer and 28.0%in spring.The rate of urban burns was 34.2%and that of rural burns was 65.8%.The improvement rate was 59.2%，the cure rate was 37.2%，and the mortality was 0.2%at discharge.There were statistically significant differences between male and female patients in burn types（χ
2
=12.667，P=0.027）.There were statistically significant differences in burn types among Han，Hui and other ethnic minority children（χ
2
=4.082，P=0.944）.There were statistically significant differences in the burn types among the three age groups（χ
2
=597.234，P＜0.01）.There were statistically significant differences in burn types among burn patients in 7 years（χ
2
=53.877，P=0.005）.There were statistically significant differences in burn types on seasonal distribution （χ
2
=44.618，P＜0.01）.
Conclusion
Among the children with burns，most of them are male，and the proportion of infants aged≤3 is the highest.The hydrothermal burn is the main cause of burn injuries.The proportion of rural children is higher than that of urban children.Summer is the highoccurrence season for the burns，followed by spring.
2019 Vol. 26 (6): 12-15 [
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105
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16
Research progress of the relationship between leukocyte subsets and the prognosis of ischemic stroke
YUAN Mao-ting LI Guang-qin
Stroke is known as its high fatality and high morbidity，approximately 70%of which are cerebral infarction.The prognosis after stroke is closely related to the quality of life of patients.The prediction of post-stroke prognosis at admission can guide clinical treatment，nursing and rehabilitation programs.White blood cells are the main blood cells that mediate the immune response in human body，they are divided into neutrophils，lymphocytes and eosinophils and so on.The neutrophils and lymphocytes account for 60%-90%.Studies have shown that neutrophil counts，lymphocyte counts，and neutrophil/lymphocyte ratios are closely related to short-term prognosis of ischemic stroke.This article reviews the relationship between neutrophils and lymphocytes and short-term prognosis of acute ischemic stroke and its mechanism to guide early clinical intervention and improve poor prognosis.
2019 Vol. 26 (6): 16-19 [
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89
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20
Advances in clinical anesthesia methods for lower extremity surgery in elderly patients
LIU Zhao-hui
For elderly patients，the increased bone vulnerability and physical strength are likely to increase their fracture risk.However，due to the decline of the body function of elderly patients，the intraoperative anesthesia is intolerant，which leads to more complications.It is very important to choose an effective and safe anesthesia method during surgery，which can promote the smooth implementation of the operation and reduce the postoperative complications.This avticle reviewed the research progress of clinical anesthesia methods for lower limb surgery in elderly patients.
2019 Vol. 26 (6): 20-22 [
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90
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23
Research progress of the pathogenesis and treatment of gastroesophageal reflux disease
LIU Yun YU Hong-bo
Gastroesophageal reflux disease for human body dynamic functional disorder of upper gastrointestinal tract disease，most patients with intractable cough and heartburn symptoms.The pathogenesis of the disease and a variety of factors related to the pathogenesis of gastroesophageal reflux disease mainly includes functional esophageal disorders，acid bag effect，changes in human esophageal epithelial permeability，Helicobacter pylori infection，saliva defensive role，etc.，but the symptoms of gastroesophageal reflux disease limited to the human body in the digestive tract，also affects the human digestive tract of the throat and lungs，cause serious influence to human body health.Through the analysis of the pathogenesis of the disease，and then take appropriate treatment，can improve the prognosis of patients with gastroesophageal reflux disease and promote the early rehabilitation of patients.Therefore，the pathogenesis and treatment of gastroesophageal reflux disease are reviewed in this paper.
2019 Vol. 26 (6): 23-25 [
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92
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26
Preliminary mechanism study of convulsive behavior induced by corticotropin releasing hormone infusion into lateral ventricle in immature rats
ZHOU Hao ZHAO Wei-qing CUI Yu-xia LIU Kai-yu
Objective
To investigate the preliminary mechanism study of convulsive behavior induced by corticotropin releasing hormone（CRH）infusion into lateral ventricle in immature rats.
Methods
All SD immature rats were randomly divided into the blank experimental group （only lateral ventricular implant catheter，n=10），the artificial cerebrospinal fluid perfusion group（lateral ventricular perfusion artificial cerebrospinal fluid，n=10），the CRH perfusion group（lateral ventricular perfusion CRH，n=10）.The SD immature rats were performed lateral ventricle infusion at 18 days after birth and using the lateral ventricular microperfusion and whole-cell patch clamp to detect the influence of CRH for membrane potential of pyramidal neurons at hippocampal.
Results
Convulsion behavior could be induced by CRH of（5±3）μl infusion into the lateral ventricle of SD immature rats，while the other groups were not clearly observed.The spontaneous discharge frequency of pyramidal neurons in CRH infusion in hippocampal slices was（［5.67±1.75］Hz），which was significantly faster than before CRH infusion in hippocampal slices （［2.23±1.12］Hz）and after CRH infusion in hippocampal slices（［1.28±0.72］Hz）（P＜0.01）.
Conclusion
CRH administered into cerebral ventricles can induce convulsive behavior in immature rats，and increasing excitability of pyramidal neurons，which can be used as the potential mechanisms.
2019 Vol. 26 (6): 26-28 [
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83
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29
Diagnostic value of immunohistochemistry in tissue typing of lung cancer biopsy
DU Gui-qing； WANG Qiu-hong； DENG Gui-xia； QIAO Ting-ting； NIE Yan-rong； MA Dan-qi；JIA Rui
Objective
To observe the differential expression of various immunohistochemical antibodies in different types of lung cancers，to explore their value in the differential diagnosis of various types of lung cancer，and to find the most cost-effective immunohistochemical antibody combination.
Methods
A total of 78 patients with lung cancer diagnosed by lung biopsy from October 2013 to May 2015 were enrolled in this study.Immunohistochemical staining was performed to observe the expression of immunohistochemical antibodies in lung cancer.
Results
High expression of p63，p40 and CK5/6 were in lung squamous cell carcinoma，Napsin A and CK7 were in high expression in lung adenocarcinoma，and TTF-1，CgA，Syn and CD56 were in high expression in small cell lung cancer and neuroendocrine carcinoma.
Conclusion
The expression of immunohistochemical antibodies plays a key role in the typing of lung cancer.Rational application of immunohistochemical antibodies is beneficial for clear lung cancer classification and guidance of clinical work.
2019 Vol. 26 (6): 29-31 [
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90
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Comparison of pathological features between young breast cancer and postmenopausal breast cancer
HE Wei-hua
Objective
To analyze and compare the pathological features of young breast cancer and postmenopausal breast cancer.
Methods
A total of 30 cases of young breast cancer patients（group A）and 30 cases of postmenopausal breast cancer patients（group B）admitted to our hospital from January 2015 to January 2018 were selected.The outcomes of tumor-related factors，breast cancer molecular typing，breast cancer histological grade and clinical stage were observed and recorded in the two groups.
Results
The positive rates of progesterone receptor（PR）and estrogen receptor（ER）in group A were lower than those in group B （P＜0.05）.The positive rate of human epidermal growth factor receptor（HER-2）and high expression of related nuclear antigen in tumor cell proliferation （Ki-67）in group A were higher than those of group B （P＜0.05）.The proportion of Luminal A type in group A was lower than that in group B，and the proportion of triple negative type in group A was higher than that in group B （P＜0.05）.In group A，the proportion of histological grade Ⅰ was lower than that of group B（P＜0.05），the proportion of type Ⅱ in group A was lower than that in group B （P＜0.05）.
Conclusion
The pathological characteristics of young breast cancer and postmenopausal breast cancer are quite different.It is necessary to give full attention to the clinical development of treatment plan and the evaluation of effect and prognosis.
2019 Vol. 26 (6): 32-34 [
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88
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35
Current situation analysis of clinical characteristics and diagnosis and treatment of rheumatic immune diseases in the observation group
HUANG Zhi-rao
Objective
To understand and analyze the clinical characteristics，diagnosis and treatment current situation of rheumatic immune diseases in our hospital，so as to provide reference for the treatment of rheumatic immune diseases in Wuyuan area.
Methods
From June 11，2016 to June 11，2017，altogether 86 cases of rheumatoid arthritis（RA）and gout registered by our department inChinese rheumatism data center（CRDC）were selected as the research objects，and the national population of RA and gout during the same period were selected as the control.Clinical characteristics and diagnosis and treatment of the two were summarized.
Results
The age of onset，the age of diagnosis，the number of moderate/severe proportion and the follow-up rate of RA patients in our hospital were higher than those in the data center.The age of onset，the age of diagnosis and the rate of persistent attack of gout patients in our hospital were higher than those in the data center.The follow-up rate and the incidence rate of complications of gout patients in our hospital were similar to those in the data center.The utilization rates of Methotrexate，Hydroxychloroquine and Yunke in RA patients in our hospital were higher than those in the data center，and the utilization rates of Febuxostat and Colchicine of gout patients in our hospital were higher than those in the data center.
Conclusion
The main clinical characteristics of rheumatic immune disease are high age of onset，more male patients than female，and most patients are complicated with gouty stones.At present，immunosuppressive drugs are mainly used to treat rheumatic immune disease.The diagnosis and treatment behavior should be standardized，patient education should be done well，and follow-up rate should be improved to delay the progress of patients′condition to prevent complications.
2019 Vol. 26 (6): 35-38转71 [
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104
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39
Clinical effect of closed drip irrigation combined with vacuum sealing drainage in the treatment of infectious pressure sores or skin ulcers
JIE Mu-fu ；OU Guan-zhou； ZHU Zui-cheng
Objective
To investigate the clinical effect of closed drip lavage combined with vacuum sealing drainage（VSD）in the treatment of infectious pressure sores or skin ulcers.
Methods
From July 2016 to June 2018，96 patients with pressure ulcers or post-traumatic skin ulcers （not included in diabetes）admitted to our hospital（including the General Hospital）were enrolled.According to the willingness to participate in this research project，they were divided into the control group（34 cases）and the treatment group（62 cases）.In the control group，wound clearance using traditional dressing change was used，while in treatment group，closed drip lavage and VSD treatment was added on the basis of the control group.The clinical indicators were compared in the two groups.
Results
The infection control time was（13.1±4.5）d in the treatment group，which was significantly lower than that in the control group（［21.4±5.2］d）（P＜0.05）.In the treatment group，wound skin grafting was performed（10.0±0.8）d after the fresh ulcer wound drainage，and the rest of the wound lasted for（14.5±2.5）d.In some cases，dressing change continued to wound healing.The average wound surface qualified for the skin grafting was（14±2.6）d.The hospital stay in the treatment group was（20.5±4.2）d，which was shorter than that in the control group （［27.4±3.6］d），the hospitalization cost of the treatment roup was more than that in the control group，with significant difference （P＜0.05）.The total effectiveness rate of the treatment group after treatment was 95.16%，which was much lower than that of the control group accounting for 58.82%，with statistical difference（P＜0.05）.
Conclusion
For patients with infectious pressure sores or skin ulcers，closed drip lavage combined with VSD can effectively remove the secretions，necrotic tissue and cavity gap in the wound surface.The therapeutic effect is remarkable and is recommended to be widely used.
2019 Vol. 26 (6): 39-41 [
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Relationship between burn severity and pathogen infection wound-blood transmission evaluated based on Ryan score
YE Hua； ZHOU Xiao-liang； TU Jia-jin； XU Ze-hua； WANG Xian-lin
Objective
To explore the relationship between severity of burn and pathogen infection wound-blood transmission evaluated based on Ryan score，and to provide evidence for rational and systematic application of antibiotics in burn patients.
Methods
A retrospective analysis was made of 230 severely burned patients admitted to our hospital from April 2014 to April 2018.All patients were divided into four groups （0，1，2，3 groups）according to Ryan score for descriptive statistical analysis.The relationship between severity of burn and wound-blood transmission of pathogen infection was independent variable and severity of burn was dependent variable.The influence of Ryan score on wound-blood transmission was analyzed and evaluated.The positive rate of wound culture in patients with positive blood culture was analyzed based on Ryan score.
Results
The positive rate of wound culture in the four positive bloodborne groups were 15.7%，63.8%，82.5%and 36.3%.The bacterial flora of wound culture was consistent with that of blood culture in severely burned patients.There was a certain correlation between the blood-borne pathogenic bacteria and the severity of burn （OR=0.124，95%CI=0.029-0.650）.The blood-borne transmission of pathogenic bacteria in wounds was a correlative factor of severity of burn.
Conclusion
Ryan score can effectively evaluate the relationship between the severity of burn and the spread of pathogens to blood in severely burned patients.
2019 Vol. 26 (6): 42-44 [
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Effect observation of nasal high-flow oxygen therapy on respiratory failure
PAN Jian-jia ；LUO Shu-yu
Objective
To investigate the therapeutic effect of nasal high-flow oxygen therapy on respiratory failure.
Methods
A total of 60 patients with respiratory failure admitted to our department from June 2017 to November 2018 were selected as the study subjects.They were divided into the control group （27 cases）and the observation group（33 cases）according to admission time.Patients in the control group were treated with non-invasive mechanical ventilation after respiratory failure，while patients in the observation group were treated with nasal high-flow oxygen therapy.The arterial blood carbon dioxide partial pressure （PaCO
2
），partial oxygen partial pressure （PaO
2
），re-intubation rate after treatment，ICU stay，and hospital stay were compared between the two groups.
Results
After treatment，the level of Pa-CO
2
in the observation group was significantly lower than that in the control group，the level of PaO
2
in the observation group was significantly higher than that in the control group，with significant difference（P＜0.05）.There were no significant differences in the heart rate and respiratory rate between the two groups after treatment（P＞0.05）.The re-intubation rate of the observation group was 6.06%，which was lower than that of the control group accounting for 33.33%，the number of ICU stay and hospital stay were （9.78±2.86）d and （24.82±3.75）d in the observation group，which were greatly shorter than those in the control group （［12.57±3.35］d and ［29.54±4.11］d），the differences were statistically significant（P＜0.05）.
Conclusion
The use of nasal high-flow oxygen therapy for patients with respiratory failure is convenient and economical，and can achieve satisfactory effect，effectively improve patients′breathing difficulties，reduce the rate of tracheal intubation，and enhance the quality of life.
2019 Vol. 26 (6): 45-47 [
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Clinical effect of Eucalyptol Limonene and Pinene Enteric Soft Capsules combined with Ambroxol Hydrochloride in the treatment of senile pneumonia
SHU Jiao-jie； LIU Si-bo； LIU Guo-liang ；ZHOU Heng-jie ；GE Dong
Objective
To investigate the clinical effect of Eucalyptol Limonene and Pinene Enteric Soft Capsules combined with Ambroxol Hydrochloride in the treatment of senile pneumonia.
Methods
A total of 50 elderly patients with pneumonia admitted to our hospital from December 2015 to December 2017 were selected as the research objects.According to the random number table method，the patients were divided into the control group （n=25）and the study group（n=25）.The control group was treated with Ambroxol Hydrochloride，and the study group was treated with Eucalyptol Limonene and Pinene Enteric Soft Capsules on the basis of the control group.The two groups were treated for 2 weeks.The clinical efficacy of two groups after treatment，TCM syndrome score of clinical symptoms and the level of inflammatory factors（interleukin-6 ［IL-6］，C-reactive protein ［CRP］，tumor necrosis factor-α ［TNF-α］and macrophage migration inhibitory factor ［MIF］）of the two groups before and after treatment was compared.The adverse reaction of the two groups during treatment was observed.
Results
The total effective rate of the study group was 96.00%（24/25），which was significantly higher than 76.00%（19/25）of the control group（P＜0.05）.The TCM syndrome score of clinical symptoms in the two groups after 1，2 weeks of treatment was lower than that before treatment，and that in the study group was lower than that in the control group （P＜0.05）.After treatment，the level of IL-6，CRP，TNF-α and MIF in the two groups was lower than that before treatment，and that in the study group was lower than that in the control group （P＜0.05）.There was no significant difference in the total incidence of adverse reactions between the two groups（P＞0.05）.
Conclusion
Eucalyptol Limonene and Pinene Enteric Soft Capsules combined with Ambroxol Hydrochloride in the treatment of senile pneumonia has definite curative effect.It can significantly improve the clinical symptoms of patients，reduce the level of inflammatory factors，and has good safety.It has certain clinical application value.
2019 Vol. 26 (6): 48-51 [
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176
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Clinical effect of low dose Colchicine combined with Etoricoxib in the treatment of acute gouty arthritis
CAI Ting
Objective
To evaluate the clinical effect of the combination of Colchicine with Etoricoxib in the treatment of acute gouty arthritis.
Methods
A total of 90 cases of acute gout arthritis treated in the department of rheumatology of our hospital from January 2017 to September 2018 were selected as the research objects.According to the different research methods，they were divided into group A，group B and group C，30 patients in each group.Group A was treated with Colchicine in low dose.Group B was treated with Colchicine combined with Dexamethasone.Group C was treated with Colchicine combined with Etoricoxib.The laboratory physicochemical indexes including UA，ESR，CRP，WBC，ALT，GFR and VAS were compared among the three groups.
Results
After treatment，the level of UA，ESR，CRP，WBC and VAS scores in group C were lower than those in group A and B，with statistically significant differences（P＜0.05）.There was no significant difference in the level of ALT，GFR and the incidence of adverse reactions in the three groups between before and after treatment（P＞0.05）.
Conclusion
Low-dose Colchicine combined with Etoricoxib in the treatment of acute gouty arthritis，the pain symptoms of patients are significantly alleviated，the effect is significant.
2019 Vol. 26 (6): 52-54 [
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170
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Clinical effect of upper limb unsupported exercise training combined with Aminophylline in the treatment of stable patients with severe chronic obstructive pulmonary disease
TAO Ying-fu
Objective
To explore the clinical effect of upper limb unsupported exercise training combined with Aminophylline in the treatment of stable patients with severe chronic obstructive pulmonary disease（COPD）.
Methods
A total of 100 patients with stable severe COPD admitted to our hospital from March 2016 to January 2018 were selected as study objects，and they were divided into the observation group（n=50）and the control group（n=50）according to different treatment methods.The control group was treated with Aminophylline，the observation group was treated with upper limb unsupported exercise training on the basis of the control group.The levels of corticotropin releasing factor（CRF），fibrinogen（Fbg），lung function（total volume，FVC），respiratory status（partial pressure of arterial oxygen，PaO
2
），serum procalcitonin（PCT）and brain natriuretic peptide（BNP）were compared between the two groups after treatment.
Results
After treatment，the level of FVC and PaO
2
in the observation group were higher than those in the control group，while the level of Fbg，CRF，PCT and BNP in the observation group were lower than those in the control group （P＜0.05）.
Conclusion
The effect of upper limb unsupported exercise training combined with Aminophylline in the treatment of stable patients with severe COPD is definite，which can improve pulmonary function and tracheal ventilation level，and reduce the effect of inflammatory factors.
2019 Vol. 26 (6): 55-57 [
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Clinical effect of the sequential therapy of estrogen and progesterone in the treatment of patients after induced abortion with intrauterine residue
WANG Zeng-jie； WANG Hong；LI Yan-xia
Objective
To investigate the clinical effect of the sequential therapy of estrogen and progesterone in the treatment of patients after induced abortion with intrauterine residue.
Methods
A total of 70 patients after induced abortion with intrauterine residue who visited the outpatient department of our hospital from January 2016 to December 2017 were selected as the research objects.They were randomly divided into the treatment group and the control group，35 cases in each group.The treatment group were treated with the sequential therapy of estrogen and progesterone，the control group were given curettage.The menstrual blood volume，the thickness of endometria after menstruation and the removal of residual tissue in the uterine cavity of the two groups after treatment were observed，then the therapeutic effect of the two groups was compared.
Results
The first enstrual blood volume in the treatment group was（78.46±20.03）ml，which was more than that in the control group of（61.89±17.67）ml，and there was significant difference between the two groups（P＜0.05）.The endometria thickness after menstruation of the treatment group was（6.03±1.24）mm，which was thicker than that of the control group of（4.19±1.29）mm，and there was significant difference between the two groups（P＜0.05）.There was no statistically significant difference in cure rate between the two groups of patients （P＞0.05）.
Conclusion
The sequential therapy of estrogen and progesterone is effective in the treatment of patients with intrauterine residue after abortion，which is worthy of clinical promotion.
2019 Vol. 26 (6): 58-60 [
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Clinical effect of Octreotide in the adjuvant treatment of mild acute pancreatitis
TIAN Jin ；JI Zhi-fei
Objective
To explore the clinical effect of Octreotide in the adjuvant treatment of mild acute pancreatitis.
Methods
A total of 96 patients with mild acute pancreatitis admitted to our hospital from January 2017 to September 2018 were enrolled in the study.They were divided into the control group and the study groups according to random number table method，48 cases in each group.The patients in the control group were treated with Ulinastatin，the patients in the study group were treated with adjuvant Octreotide.The clinical efficacy，the level of interleukin-1 （IL-1），interleukin-6（IL-6），interleukin-10（IL-10），interleukin-12（IL-12），superoxide dismutase（SOD），malondialdehyde（MDA），and adverse reactions were compared between the two groups.
Results
The clinical total effective rate of the study group（93.75%）was higher than that of the control group（79.17%）（P＜0.05）.There were no significant differences in the level of IL-1，TL-6，IL-10，IL-12，SOD and MDA between the two groups before intervention （P＞0.05）.After intervention，the levels of IL-1，TL-6，IL-10，IL-12 and MDA in both groups were lower than those before intervention，and the SOD level was higher than that before intervention（P＜0.05）.After intervention，the SOD level of the study group was higher than that of the control group，and the levels of IL-1，TL-6，IL-10，IL-12 and MDA of the study group were lower than those of the control group （P＜0.05）.There was no significant difference in the incidence of adverse reactions between the study group（6.25%）and the control group（4.17%）（P＞0.05）.
Conclusion
Octreotide-assisted Ulinastatin is effective in the treatment of mild acute pancreatitis，which can significantly reduce the inflammatory response and improve the level of oxidative stress.
2019 Vol. 26 (6): 61-63 [
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Meta analysis of efficacy of Tigecycline in the treatment of carbapenemresistant Klebsiella pneumoniae infections
HOU Si-yuan ；TAN Yong-feng ；FENG Xing-huo
Objective
To systematically evaluate the efficacy of Tegacycline monotherapy and combination therapy in the treatment of carbapenem-resistant Klebsiella pneumonia （CRKP）infections.
Methods
The clinical studies of Tegacycline in the treatment of CRKP were retrieved from Cochrane Library，Embase，Pubmed，China National Knowledge Infrastructure （CNKI）and China Biology Medicine disc （CBM）by computer from the construction of the library to September 2018.Two reviewers independently retrieved studies according to the inclusion and exclusion criteria，assessed the methodological quality of included trials，and extracted data.The data analysis was performed by Review Manager 5.3 software.The odds ratio （OR）and 95%confidence intervals （CI）were calculated for outcome analysis.
Results
A total of 9 studies were included in this study.There was no significant difference in the mortality of CRKP infection between Tegacycline monotherapy and other monotherapy（OR=1.07，95%CI=0.63-1.82，P=0.8）.There was no significant difference in mortality among CRKP patients treated with Tigacycline-based combination therapy compared with other drugs combination therapy（OR=1.40，95%CI=0.89-2.21，P=0.15）.
Conclusion
Both Tigecycline monotherapy and Tigecycline-based combination therapy do not significantly improve the mortality of patients with CRKP infections.This conclusion needs more large sample and high quality clinical randomized controlled trials to confirm.
2019 Vol. 26 (6): 64-67 [
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91
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68
Effect comparsion of laparoscopic totally extraperitoneal herniorrhaphy and transperitoneal preperitoneal herniorrhaphy in the treatment of adult inguinal hernia
YANG He-yan ；HUANG Jin-tuan
Objective
To compare the effect of laparoscopic totally extraperitoneal herniorrhaphy （TEP）and transperitoneal preperitoneal herniorrhaphy （TAPP）in the treatment of adult patients with inguinal hernia.
Methods
A total of 126 cases of patients with inguinal hernia in our hospital from January 2016 to May 2017 were selected as the study objects，and they were divided into the TEP group（64 cases）and the TAPP group（62 cases）according to different operative methods.The TEP group was treated with TEP，and the TAPP group was treated with TAPP.The operation indexes and recurrence status of the two groups were observed and compared.
Results
The operation time and hospitalization time in the TEP group were longer than those in the TAPP group，the blood loss in the TEP group was more than that in the TAPP group，and the differences were statistically significant（P＜0.05）.The wound diameter，the times of painkillers used，pain score，sleep quality score and treatment cost in the TAPP group were lower than those in the TAPP group，and the differences were statistically significant（P＜0.05）.There was no significant difference in the total incidence rate of complications between the two groups（P＞0.05）.There was no significant difference in the recurrence rate between the two groups（P＞0.05）.
Conclusion
TEP and TAPP both have good therapeutic effect on adults with inguinal hernia，which are safe and effective.The appropriate treatment can be chosen according to the situation of patients in clinic.
2019 Vol. 26 (6): 68-71 [
Abstract
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88
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72
Clinical effect of closed thoracic drainage with abdominal drainage catheter in the treatment of pleural effusion
LIU Xiao-bo；ZHOU Guang-hai；WEI Li-huang；OU Jian-min
Objective
To observe and analyze the clinical effect of closed thoracic drainage with abdominal drainage catheter in the treatment of pleural effusion.
Methods
Altogether 146 patients with pleural effusion who were treated in our hospital from May 13，2016 to May 12，2017 were selected and randomly divided into the observation group and the control group，73 patients in each group.The observation group was given abdominal drainage catheter，and the control group was given central venous catheter.The fever abatement time，hospitalization time，disappearance time of pleural effusion，drainage time，the total incidence rate of complication and the total effective rate were compared between the two groups.
Results
The duration of fever abatement，hospitalization，pleural fluid disappearance and drainage of the observation group were shorter than those of the control group，with statistically significant difference（P＜0.05）.The total incidence rate of complications of the observation group was lower than that of the control group，with statistically significant difference（P＜0.05）.The total effective rate of the observation group was higher than that of the control group，with statistically significant difference（P＜0.05）.
Conclusion
Closed thoracic drainage with abdominal drainage catheter in the diagnosis and treatment of pleural effusion can effectively reduce the incidence of complications in patients，which is of high clinical value.
2019 Vol. 26 (6): 72-74 [
Abstract
] (
87
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75
Application value of thromboelastography in coagulation assessment of idiopathic thrombocytopenic purpura
HUANG Ting
Objective
To study the application value of thromboelastography in coagulation assessment of idiopathic thrombocytopenic purpura.
Methods
A total of 76 patients with idiopathic thrombocytopenic purpura who were admitted to our hospital from June 2017 to June 2018 were enrolled in the study.A total of 76 healthy people who underwent normal blood donation in our hospital at the same time were selected.All patients underwent thromboelastography to detect reaction time in blood，clot formation time，Angle angle，maximum amplitude，comprehensive coagulation index，LY30（percentage of clot ablation at 30 minutes of maximum amplitude），etc.，and the values of the two groups of people were compared to observe the coagulation function of all personnel.
Results
The reaction time and blood clot formation time of the observation group were longer than those of the control group，and the LY30 of the observation group was higher than that of the control group，the difference was statistically significant（P＜0.05）.The Angle angle，maximum amplitude and comprehensive coagulation index of the observation group were lower than those of the control group，the difference was statistically significant（P＜0.05）.
Conclusion
The thromboelastography test in patients with idiopathic thrombocytopenic purpura can observe the dynamic changes of blood coagulation in patients and play an important role in evaluating the coagulation function of patients.
2019 Vol. 26 (6): 75-77 [
Abstract
] (
90
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Influence of bronchoalveolar lavage on pulmonary function in patients with pulmonary abscess and bronchiectasis complicated with infection
#br#
Influence of bronchoalveolar lavage on pulmonary function in patients with pulmonary abscess and bronchiectasis complicated with infection #br#[J]. 中国当代医药, 2019,26(6): 78-80')" href="#">
TU Zhi-yi；YANG Zhi-ming； HE Tao ；ZOU Tian-shi
Objective
To study the influence of bronchoalveolar lavage on pulmonary function in patients with pulmonary abscess and bronchiectasis complicated with infection.
Methods
A total of 84 patients with pulmonary abscess and bronchiectasis complicated infection who were admitted to our hospital from January 2017 to January 2018 were selected as the research objects.The patients were divided into the control group（42 cases）and the experimental group（42 cases）by randomized method.Patients in the control group received conventional drug therapy，and patients in the experimental group received bronchoalveolar lavage.The lung function，treatment effect and adverse reactions of the two groups were compared.
Results
After treatment，the level of breathing volume （FVC），maximum expiratory volume in one second（FEV
1
），maximum expiratory flow（PEF）of the experimental group were higher than those of the control group，the difference was statistically significant（P＜0.05）.The total effective rate of the experimental group was higher than that of the control group，the difference was statistically significant（P＜0.05）.The total incidence of adverse reactions in the experimental group was lower than that in the control group，the difference was statistically significant（P＜0.05）.
Conclusion
Patients with pulmonary abscess and bronchiectasis combined with bronchoalveolar lavage can effectively improve the lung function of patients，which is worthy of popularization and application.
2019 Vol. 26 (6): 78-80 [
Abstract
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84
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81
Application effect comparison of four intermuscular sulcus brachial plexus block methods in the upper limb surgery for obese patients
TANG Qun-jie；YE Wei-biao； FANG Jian-qin；HUANG Guang-yong；ZHENG Jian-yu
Objective
To compare the application effect of blind probe method，nerve stimulator guidance method，ultrasonic guidance method and ultrasound combined with nerve stimulator guidance method for the intermuscular sulcus brachial plexus block in the upper limb surgery for obese patients.
Methods
A total of 120 obese patients who underwent elective upper extremity surgery in Foshan Sanshui District People′s Hospital of Guangdong Province from January to December 2017 were selected as sudy subjects.They were divided into A，B，C and D groups according to the random number table method，30 cases in each group.Traditional anatomical localization to find the heterosexual method （blind probe method）was used in group A，nerve stimulator guidance method was used in group B，ultrasonic guidance method was used in group C，and ultrasound combined with nerve stimulator guidance method was used in group D.The operation completed time for nerve block，the onset time of sensory nerve block，the block improvement effect，and total incidence rate of complications were compared among the four groups.
Results
The operation completed time for nerve block in group B，C，and D was significantly shorter than that in group A，and the differences were statistically significant（P＜0.05）.The operation completed time for nerve block in group C and D was significantly shorter than that in group B，and the differences were statistically significant（P＜0.05）.The operation completed time for nerve block in group D was significantly shorter than that in group C，and the difference was statistically significant（P＜0.05）.The onset time of sensory nerve block in group B，C，and D was significantly shorter than that in group A，and the differences were statistically significant（P＜0.05）.There was no significant difference in the onset time of sensory nerve block among the B，C，and D groups（P＞0.05）.The block improvement effect in group B，C and D was better than that that in group A，and the differences were statistically significant（P＜0.05）.The block improvement effect in group C and D was significantly better than that that in group B，and the differences were statistically significant（P＜0.05）.The block improvement effect in group D was better than that that in group C，and the difference was statistically significant（P＜0.05）.The total incidence rate of complications in group B，C and D was significantly lower than that that in group A，and the differences were statistically significant（P＜0.05）.There was no significant difference in the total incidence rate of complications between the group B and group C（P＞0.05）.The total incidence rate of complications in group D was significantly lower than that in group B and C，and the differences were statistically significant（P＜0.05）.
Conclusion
Compared with the blind probe method，the ultrasonic guidance method has the advantages of short operation time，short block effect time，high blockade improvement rate and low complication rate in the intermuscular sulcus brachial plexus block of the upper limb surgery for obese patients.The ultrasound combined with nerve stimulator guidance method can further expand the advantages.
2019 Vol. 26 (6): 81-84转88 [
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97
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Application effect comparison bewteen spinal anesthesia with No.26 LP needle and combined spinal-epidural anesthesia in cesarean section
LUO Nai-rong； HUANG Zhong-yang； WU Hai-bin； LI Guang-xiang； OU Jian-ying； LIN Feng-yi
Objective
To compare the application effect bewteen spinal anesthesia （SA）with No.26 LP needle and combined spinal-epidural anesthesia （CSEA）in cesarean section.
Methods
From January to June 2018，a total of 100 pregnant women who intended to undergo cesarean section in our hospital were selected as research objects and divided into SA group（50 cases）and CSEA group（50 cases）according to the random number table method.The SA group received SA with No.26 LP needle，and the CSEA group received CSEA.The onset time of anesthesia，sensory block recovery time，exercise block recovery time，excellent and good rate of anesthesia，blood pressure（systolic blood pressure，diastolic blood pressure），and heart rate before and after anesthesia and adverse reactions were compared bewteen the two groups.
Results
The onset time of anesthesia，sensory block recovery time and exercise block recovery time in the CSEA group were significantly shorter than those in the SA group，and the differences were statistically significant（P＜0.05）.The excellent and good rate of anesthesia in the CSEA group was 92.00%，compared with 90.00%in the SA group，and the difference was not statistically significant（P＞0.05）.There were no significant differences in systolic blood pressure，diastolic blood pressure and heart rate between the two groups before anesthesia（P＞0.05）.The systolic and diastolic blood pressures after anesthesia of the two groups were lower than those before anesthesia，and the differences were statistically significant（P＜0.05）.There was no significant difference in heart rate between the two groups before and after anesthesia （P＞0.05）.The systolic blood pressure after anesthesia in the SA group was higher than that in the CSEA group，and the difference was statistically significant（P＜0.05）.There were no significant differences in pressure and heart rate between the two groups after anesthesia （P＞0.05）.The total incidence rate of adverse reactions in the SA group was 4.00%，which was significantly lower than that in the CSEA group accounting for 26.00%，and the difference was statistically significant（P＜0.05）.
Conclusion
s Both SA with No.26 LP needle and CSEA meet the anesthesia requirements of cesarean section.CSEA has a better time control，SA with No.26 LP needle has less impact on maternal circulation and fewer adverse reactions，which should be reasonably selected according to the situation.
2019 Vol. 26 (6): 85-88 [
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78
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89
Effect and safety of high intensity focused ultrasound in the treatment of T2WI High signal uterine leiomyoma
CHI Lei；YU Bao-long；ZHOU Jia；CHEN Xiang-ru
Objective
To explore the effect and safety of high intensity focused ultrasound in the treatment of T2WI high signal uterine leiomyoma.
Methods
A total of 160 patients with hyperintense uterine fibroids on T2WI admitted to our hospital from May 2014 to July 2017 were selected as the study subjects，all patients were treated with high intensity focused ultrasound.The volume ablation rate and energy efficiency factor（EEF）level of uterine leiomyoma in different parts of patients were compared.The volume ablation rate and EEF level of uterine leiomyoma in different sizes of patients were compared.All patients were followed up for one year，and the effects of high intensity focused ultrasound on vaginal secretion and ovarian function were recorded and evaluated.Adverse reactions after high intensity focused ultrasound treatment were recorded and evaluated.
Results
The volume ablation rate of uterine leiomyoma in the posterior wall was lower than that in the anterior wall，and the EEF level was higher than that in the anterior wall and the lateral wall，the differences were significant（P＜0.05）.There was no significant difference in volume ablation rate between different size uterine leiomyomas （P＞0.05）.The EEF level of uterine leiomyoma with mean diameter ＞ 7 cm was lower than that of uterine leiomyoma with mean diameter＜ 4 cm and 4-7 cm，the differences were statistically significant（P＜0.05）.After 3 months of HIFU treatment，no abnormalities were found in estrogen，progesterone and follicle stimulating hormone levels.No serious adverse reactions occurred.The incidence of vaginal secretion abnormality in patients with uterine cavity distance less than 5 mm was lower than that in patients with uterine cavity distance more than 5 mm，the difference was significant（P＜0.05）.
Conclusion
s High intensity focused ultrasound is effective，safe and reliable in the treatment of hyperintense uterine fibroids on T2WI，which is worthy of clinical application.
2019 Vol. 26 (6): 89-91转95 [
Abstract
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83
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92
Diagnostic value of diffusion-weighted magnetic resonance imaging combined with magnetic resonance spectroscopy in the nature of prostatic lesions
GUO Zuo-liang；MA Xing-can；CHEN Ning；MA Shu-hua
Objective
To explore the diagnostic value of diffusion weighted magnetic resonance imaging （DWI）combined with magnetic resonance spectroscopy （MRS）in the nature and type of prostatic lesions.
Methods
Thirty-eight patients diagnosed as prostate cancer（PCa）in chaonan Minsheng hospital pf shantou from January 2016 to September 2018 were selected as observation group and 38 patients diagnosed as BPH as control group.DWI，MRS and DWI combined with MRS were performed in both groups.The difference of ADC value and （Cho+cre）/Cit value between the two groups was observed.The diagnostic results of DWI，MRS and DWI combined with MRS and the diagnostic coincidence rate were compared between the two groups.
Results
The ADC value of the observation group at 400 s/mm
2
was（0.86±0.28），significantly lower than that of the control group，the 800 s/mm
2
was（0.74±0.39），significantly lower than that of the control group，the differences were statistically significant（P＜0.001）.The Cho+cre/Cit value in the observation group was significantly higher than that in the control group，the difference was statistically significant（P＜0.001）.Pathological results of 76 patients：45 cases of prostate cancer and 31 cases of benign prostatic hyperplasia.Compared with pathological results，36 cases were diagnosed positive by DWI and 40 cases were negative，38 cases were diagnosed positive by MRS and 38 cases were negative，36 cases were diagnosed positive by DWI combined with MRS，and 30 cases were negative.The sensitivity，specificity and accuracy of combined DWI and MRS in the diagnosis of prostate cancer were 94.74%，92.11%and 92.11%，respectively，the sensitivity，specificity and accuracy of combined examination were significantly higher than those of DWI and MRS alone，the differences were statistically significant（P＜0.05）.
Conclusion
Both DWI and MRS can effectively diagnose PCa and BPH，can accurately distinguish between PCa and BPH patients，but MRS combined with DWI has higher diagnostic accuracy for prostate cancer，it can clearly show the relationship between the microstructure and metabolic level of prostate tissue.It is superior to DWI and MRS alone.It has important significance in clinical diagnosis and can provide important basis for early diagnosis.
2019 Vol. 26 (6): 92-95 [
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71
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The applied value of MRI in the differential diagnosis of non-lactating mastitis and breast cancer
ZHOU Hua
Objective
To explore the applied value of magnetic resonance imaging（MRI）in differential diagnosis between non-lactating mastitis and breast cancer.
Methods
A retrospective analysis 27 patients of non-lactating mastitis treated in our hospital from May 18，2016 to May 18，2017 as mastitis group.93 patients of breast cancer as a breast cancer group，all patients were given MRI examination and the results were compared.
Results
There was no significant difference in the imaging characteristics between the two groups （P＞0.05）.The distribution of TIC type Ⅰ in mastitis group was higher than that in breast cancer group，and the the distribution of TIC typeⅡ in mastitis group was lower than that in breast cancer group，with statistical significances（P＜0.05）.There was no significant difference in the distribution of TIC type Ⅲ between the two groups （P＞0.05）.
Conclusion
It is of great significance to differentiate nonbreast-feeding mastitis from breast cancer patients by using MRI.
2019 Vol. 26 (6): 96-98 [
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68
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99
The applied value of transabdominal ultrasound combined with transperineal ultrasound in the diagnosis of placenta previa in the second trimester of pregnancy
ZHOU Fang-fei
Objective
To explore the applied value of transabdominal ultrasound combined with transperineal ultrasound in the diagnosis of placenta previa in the second trimester of pregnancy.
Methods
Fifty patients with placenta previa in the second trimester of pregnancy admitted to our hospital from January to December 2017 were selected as the study subjects，all patients underwent transabdominal ultrasonography，transperineal ultrasonography and combined transabdominal ultrasonography and perineal ultrasonography.The diagnostic accuracy，missed diagnosis，sensitivity and specificity of the three methods were compared.
Results
The diagnostic rate of transabdominal ultrasonography was significantly lower than that of transperineal ultrasonography and combined examination，the diagnostic rate of transperineal ultrasonography was significantly lower than that of combined examination，the differences were statistically significant（P＜0.05）.The rate of missed diagnosis of combined examination was significantly lower than that of transabdominal ultrasonography and perineal ultrasonography，and the rate of missed diagnosis of transperineal ultrasonography was significantly lower than that of transabdominal ultrasonography，the differences were statistically significant（P＜0.05）.The sensitivity of combined examination was higher than that of transabdominal ultrasonography and perineal ultrasonography，and the sensitivity of transperineal ultrasonography was higher than that of transabdominal ultrasonography，the differences were statistically significant（P＜0.05）.The specificity of combined examination was lower than that of transabdominal ultrasonography and perineal ultrasonography，the specificity of transperineal ultrasonography was lower than that of transabdominal ultrasonography，the differences were statistically significant（P＜0.05）.
Conclusion
The combined use of transabdominal ultrasound and perineal ultrasound in the diagnosis of placenta previa in the second trimester has high diagnostic accuracy and sensitivity，low missed diagnosis rate and specificity，which is worthy of clinical application.
2019 Vol. 26 (6): 99-101 [
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80
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Clinical effect of Ambroxol Hydrochloride in the treatment of chronic bronchitis
ZHAN Guo-xiang； LU Jing-rui
Objective
To investigate the clinical effect of Ambroxol Hydrochloride in the treatment of chronic bronchitis.
Methods
Sixty-eight patients with chronic bronchitis admitted to our hospital from August 2017 to July 2018 were selected as the research objects，they were randomly divided into control group and observation group by throwing sieve method，with 34 cases in each group.Patients in the control group were treated with routine drugs，while patients in the observation group were treated with Ambroxol Hydrochloride on the basis of the control group.The total effective rate of clinical treatment，the level of pulmonary function index and the disappearance time of symptoms were compared between the two groups.
Results
The total effective rate of clinical treatment in the observation group was 94.12%，which was significantly higher than 76.47%in the control group，the difference was significant（P＜0.05）.After treatment，the first second forced expiratory volume（FEV
1
），peak expiratory flow（PEF），FEV
1
/forced vital capacity（FVC）in the observation group were higher than those in the control group，the difference was significant（P＜0.05）.The disappearance time of each disease in the observation group was shorter than that in the control group，the difference was statistically significant（P＜0.05）.
Conclusion
Chronic bronchitis patients in the routine treatment at the same time，add Ambroxol Hydrochloride，can make faster recovery，can improve the level of pulmonary function indicators of patients，clinical application is worth promoting.
2019 Vol. 26 (6): 102-104转107 [
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82
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Preventive effect of Misoprostol rectal medication combined with Oxytocin on hemorrhage after cesarean section
PENG Yan-qiong；PENG Shi-jian
Objective
To explore the preventive effect of Misoprostol rectal medication combined with Oxytocin on hemorrhage after cesarean section.
Methods
Eighty parturients who underwent caesarean section in our hospital from January to June 2018 were randomly divided into control group and observation group，with 40 cases in each group.Both groups were given Oxytocin immediately after the delivery of the fetus，the control group received Oxytocin injection into the uterus，the observation group was given anal misoprostol after the delivery of the fetus.Observe and compare the amount of bleeding during and 24 hours after delivery，the level of hemoglobin before and after delivery and the occurrence of adverse reactions between the two groups.
Results
There was no significant difference in the amount of bleeding during operation and 24 hours after operation between the two groups（P＞0.05）.There was no significant difference in prenatal and postpartum hemoglobin levels between the two groups（P＞0.05）.There were no adverse reactions in both groups.
Conclusion
There is no difference between rectal Misoprostol Tablets combined with Oxytocin and simple use of Oxytocin in preventing postpartum hemorrhage.
2019 Vol. 26 (6): 105-107 [
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72
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108
Clinical effect of Cattle Encephalon Glycoside and Ignotin Injection combined with Shuxuetong Injection on acute cerebral infarction
LIU Bing-bo
Objective
To explore the clinical effect of Cattle Encephalon Glycoside and Ignotin Injection combined with Shuxuetong Injection in the treatment of acute cerebral infarction.
Methods
A total of 76 patients with cerebral infarction admitted to our hospital from March 2017 to May 2018 were selected as the research objects，according to the order of admission，the patients were divided into observation group and control group，with 38 cases in each group.Both groups received symptomatic treatment and antiplatelet therapy.On this basis，the control group was treated with Shuxuetong Injection，while the observation group was treated with Cattle Encephalon Glycoside and Ignotin Injection on the basis of the control group.The total effective rate and the total incidence of adverse reactions were compared between the two groups before and after treatment with the National Institutes of Health Neurological Deficiency Scale（NIHSS）score and self-care Ability scale for Daily Life （ADL）score.
Results
After treatment，the NIHSS score of the observation group was significantly lower than that of the control group，and the ADL score was significantly higher than that of the control group，the differences were statistically significant（P＜0.05）.The total effective rate was 92.11%（35/38）in the observation group，which was significantly higher than 73.68% （28/38）in the control group，the difference was statistically significant（P＜0.05）.There was no significant difference in the total incidence of adverse reactions between the two groups（P＞0.05）.
Conclusion
Cattle Encephalon Glycoside and Ignotin Injection combined with Shuxuetong Injection has a significant effect on acute cerebral infarction，which can significantly improve the neurological function and self-care ability of patients without increasing the incidence of adverse reactions.
2019 Vol. 26 (6): 108-110 [
Abstract
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59
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Effect and safety of Lansoprazole in the treatment of duodenal ulcer bleeding
DING Kai；YANG Hui
Objective
To explore the effect and safety of Lansoprazole in the treatment of duodenal ulcer bleeding.
Methods
Sixty patients with duodenal ulcer bleeding admitted to our hospital from January 2016 to August 2018 were selected as the research objects，they were divided into control group and observation group according to random number table method，with 30 cases in each group.The control group was treated with Omeprazole （40 mg，with 0.9%saline，intravenous drip，bid），while the observation group was treated with Lansoprazole（30 mg，with 0.9%saline，intravenous drip，bid），after 5 days，the hemostasis time，abdominal pain stopping time，clinical efficacy and adverse reactions were compared between the two groups.
Results
There was no significant difference in hemostasis time，abdominal pain stopping time，total effective rate and total incidence of adverse reactions between the two groups （P＞0.05）.
Conclusion
Lansoprazole has the same effect as Omeprazole in the treatment of duodenal ulcer hemorrhage.Drugs can be selected according to the specific conditions.No serious adverse reactions occur.Lansoprazole is safe and worth popularizing.
2019 Vol. 26 (6): 111-113 [
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69
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114
Clinical effect of acupuncture and moxibustion auxiliarily treating sequelae of stroke
WANG Wei；LYU Xi-hua；XIE Shi-chuan ；ZHOU Jie；WANG Zhen
Objective
To explore the clinical effect of acupuncture and moxibustion assisting rehabilitation training treating sequelae of stroke.
Methods
All of 121 patients with sequelae of stroke treated in our hospital from January 2015 to December 2017 were selected and they were randomly divided into the control group （n=60）and the observation group （n=61）according to the random number table method.Patients in the control group received simple rehabilitation training，while the observation group received acupuncture and moxibustion treatment on the basis of rehabilitation training.The treatment effect，neurological deficit score，daily living ability score and cerebral perfusion before and after treatment were compared in patients between the two groups.
Results
The total effective rate of the observation group was 88.52%，which was significantly higher than of the control group （73.33%），and the difference was statistically significant（P＜0.05）.After treatment，the National Institute of Health stroke scale （NIHSS）score of observation group was lower than that of control group，and the modified Barthel index score was higher than that of control group，and the differences were statistically significant（P＜0.05）.There was no significant difference in cerebral blood flow（CBF）values of cerebral perfusion in incerebellar cortex，thalamic nucleus，occipital lobe，frontal lobe and parietal lobe before treatment between the two groups（P＞0.05）.After treatment，the CBF values of cerebral perfusion in frontal lobe and parietal lobe of the observation group were significantly higher than those in the control group，and the differences were statistically significant（P＜0.05）.
Conclusion
Acupuncture and moxibustion assisting rehabilitation training has a good effect treating sequelae of stroke.It can effectively reduce the neurological deficit score，improve the ability of daily living，and increase the blood perfusion volume of brain tissue.
2019 Vol. 26 (6): 114-116转123 [
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81
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Effect of warm acupuncture and penetration needling combined with rehabilitation treating shoulder pain after stroke
ZHONG Ge-ling ；ZHANG Su-wan；GAO Sheng-hai
Objective
To explore the effect of warm acupuncture and penetration needling combined with rehabilitation treating shoulder pain after stroke.
Methods
All of 30 patients with shoulder pain after stroke admitted to our hospital from January 2016 to January 2018 were randomly divided into the study group and reference group，with 15 cases in each group.The reference group was given “12-needle hand and foot”combined with rehabilitation treatment，and the reference group was given warm acupuncture and penetration needling combined with rehabilitation treatment.The clinical efficacy，shoulder abduction angle（ROM），visual analogue score（VAS）of pain，upper limb motor function Fugl-Meyer（FMA）score and functional independence assessment（FIM）score before and after treatment were compared between the two groups，and the incidence of adverse reactions of the two groups were observed.
Results
The clinical efficacy of the study group was better than that of the reference group，and the difference was statistically significant（P＜0.05）.There were no significant differences in the ROM，VAS，FMA and FIM scores between the two groups before treatment（P＞0.05）.The ROM，FMA and FIM scores of the two groups were higher than those before treatment，and the VAS score was lower than that before treatment，and the differences were statistically significant（P＜0.05）.After treatment，the ROM，FMA and FIM scores of the study group were significantly higher than the reference group，and the VAS score was significantly lower than the reference group，and he differences were statistically significant（P＜0.05）.There was no adverse reactions occurred in the two groups during the treatment period.
Conclusion
Warm acupuncture and penetration needling combined with rehabilitation treating shoulder pain after stroke has a significant clinical effect，which can effectively increase mobility of shoulder joint，relieve shoulder pain，improve upper limb motor function and daily life independence ability，and have good safety.
2019 Vol. 26 (6): 117-119 [
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58
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Effect of umbilicus therapy combined with auricular point pressing treating constipation of spleen-kidney deficiency type in the recovery stage of ischemic stroke
JIANG Nan
Objective
To observe the effect of umbilicus therapy combined with auricular point pressing treating constipation of spleen-kidney deficiency type in the recovery stage of ischemic stroke.
Methods
All of 60 patients with constipation meeting the standard in Xuanwu TCM Hospital of Beijing City from March 2017 to March 2018 were selected.All patients were randomly divided into the control group and the experimental group appling the random number table method，there were 30 cases in each group.Patients in the two groups were given conventional treatment and health education.The control group was treated with umbilicus therapy，while the experimental group was given umbilical treatment combined with auricular point pressing，14 days for 1 courses.Constipation symptoms and constipation symptom scores of the two groups were observed after 14 days were a course of treatment.The curative effect of 14 days after intervention and the score of constipation symptoms before and after treatment were observed in patients of the two groups.
Results
The total effective rate of in the experimental group（90.0%）was higher than that in the control group（63.3%），and the difference was statistically significant（P＜0.05）.Before treatment，there was no significant difference in defecation frequency，abdominal distension，fecal shape，fecal incompleteness，laborious degree and defecation time score between the two groups（P＞0.05）.After treatment，the scores of the above symptoms in the two groups were lower than those before treatment，with statistical significance （P＜0.05）;after treatment，the scores of the above symptoms in the experimental group were lower than those in the control group，with statistical significance（P＜0.05）.Conclusion Umbilical therapy combined with auricular point pressing method has obvious effect treating constipation of spleen-kidney deficiency type in the recovery stage of ischemic stroke，and it is worth popularizing.
2019 Vol. 26 (6): 120-123 [
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71
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124
Individual and combined diagnosis value of serum procalcitonin and high sensitivity C-reactive protein in neonatal bacterial infectious pneumonia
CHEN Hai-tao
Objective
To explore the individual and combined diagnosis value of serum procalcitonin and high sensitivity C-reactive protein in neonatal bacterial infectious pneumonia.
Methods
From January 2017 to January 2018，80 neonates with bacterial infectious pneumonia（infection group）and 60 healthy children（healthy control group）were selected and analyzed retrospectively.Serum PCT，hs-CRP levels were compared between the two groups.The diagnostic efficiency of each index in neonatal bacterial pneumonia was compared applying the receiver operating characteristic curve （ROC）.
Results
The levels of serum PCT and hs-CRP in the infection group were significantly higher than those in the healthy control group （t=41.405，15.315，P=0.000，0.000）.The ROC curve showed that the area under the curve（AUC）in diagnosis of neonatal bacterial pneumonia of PCT combined with hs-CRP was the highest（AUC=0.934，P=0.000），followed by PCT and hs-CRP（AUC=0.862，0.828，P=0.000，0.000）.AUC of combined diagnosis was higher than PCT（Z=2.788，P=0.005）and hs-CRP（Z=3.232，P=0.001）.The best cut-off point was PCT＞0.575 μg/L and hs-CRP＞8.639 mg/L.The accuracy of PCT combined with hs-CRP was higher than PCT and hs-CRP（χ
2
=3.968，6.130，P＜0.05），the sensitivity was higher than PCT and hs-CRP （χ
2
=5.331，5.331，P＜0.05），the specificity was higher than hs-CRP（χ
2
=5.714，P＜0.05），the negative predictive value was higher than PCT and hs-CRP （χ
2
=4.283，4.720，P＜0.05），and the other differences were not statistically significant （P＞0.05）.
Conclusion
PCT and hs-CRP combined diagnosis for neonatal bacterial infectious pneumonia has better diagnostic efficacy，diagnostic accuracy，sensitivity and specificity are higher.It is worthy of clinical promotion.
2019 Vol. 26 (6): 124-126 [
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52
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127
Application value of HCV-cAg and anti-HCV IgG for joint detection in early diagnosis of hepatitis C infection
WANG Ai-lan； NI Yong-sheng； XIAN Jie-neng； HE Shi-jin； HE Si-jie； HUANG Cui-fang； YAN Wen-fen
Objective
To analyze the application value of HCV-core antigen（HCV-cAg）and anti-HCV-immunoglobulin G （anti-HCV IgG）for joint detection in early diagnosis of hepatitis C infection.
Methods
All of 296 patients with high risks of HCV infection checked from February 2015 to May 2017 in each department were selected as observation objects.All the patients received the HCV-cAg，anti-HCV，alanine aminotransferase （ALT ）and total bilirubin（TBil）examinations.HCV-RNA test results were used as the gold standard to observe the HCV infection of patients diagnosed by different methods，and to analyze the effectiveness of combined use of HCV-cAg and anti-HCV IgG in early diagnosis of diseases.
Results
HCV-RNA content was positively correlated with ALT level（r=0.978，P＜0.05），while HCV-RNA content was not correlated with Tbil level（r=0.681，P＞0.05）.The detection rate of anti-HCV IgG，HCV-cAg and serum liver function was 69.1%，82.3%and 58.2%respectively，and the detection rates of HCV-cAg was higher than that of anti-HCV IgG and serum liver function （P＜0.05）.The joint detection rate of anti-HCV IgG and HCV-cAg was the highest（96.5%），which was significantly higher than that of combined monitoring of HCV-cAg and serum liver function（90.9%），the combined detection of anti-HCV IgG and serum liver function（74.5%）had statistical difference （P＜0.05）.The diagnostic value of combined detection of HCV-cAg and anti-HCV IgG was higher than that of single index examination.
Conclusion
Combination of anti-HCV IgG and HCV-cAg for early diagnosis of HCV infection has a high clinical detection rate.
2019 Vol. 26 (6): 127-129转136 [
Abstract
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75
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130
Application value of urinary microalbumin in early diagnosis of hepatitis B virus associated glomerulonephritis
HUNAG Liang ；LIANG Zi-zhao
Objective
To discuss the application value of urinary microalbumin（U-mAlb）in early diagnosis of hepatitis B virus associated glomerulonephritis（HBV-GN）.
Methods
From March 2016 to February 2018，51 patients with HBV-GN diagnosed by pathology in the Second People′s Hospital of Zhaoqing City were selected as the observation group A.Forty-five patients with HBV infection without kidney damage were the observation group B，and 50 healthy people with negative HBV markers were selected as the control group.The levels of U-mAlb，serum creatinine（SCr），blood urea nitrogen（BUN），and β
2
-microglobulin（β
2
-MG）were detected in the three groups，and compared statistically.
Results
The levels of U-mAlb，β
2
-MG，SCr，BUN and the positive rate of U-mAlb in the observation group A were significantly higher than those in the observation group B and control group，and the differences were statistical significant（P＜0.05）.The positive rate of U-mAlb in the observation group A was significantly higher than of β
2
-MG，SCr，BUN in the same group（P＜0.05）.
Conclusion
U-mAlb can be used as an effective non-invasive marker for early diagnosis of HBV-GN，and has a great application value in clinical diagnosis.
2019 Vol. 26 (6): 130-132 [
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71
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133
Application value of TCT,HPV-DNA typing combined with colposcopy in screening cervical lesions
WU Zhi-dong；WU Zhen-yong；HUANG Cai-feng；WEN Li-juan； ZHENG Ge
Objective
To analyze the clinical application value of liquid-based thin-layer cell detection （TCT），human papillomavirus typing （HPV-DNA）typing combined with colposcopy for cervical lesion screening.
Methods
A total of 700 patients who underwent TCT，HPV-DNA typing and colposcopy in our hospital from January 2017 to June 2018 were enrolled.Pathological examination was performed on those who had abnormalities，and the pathological results and grades were used as the diagnosis results.
Results
The positive rate of TCT in 700 subjects was 17.1%（120 cases），including no clear change of atypical cells（ASCUS），the positive rate was 12.7%（89 cases），low grade squamous epithelium（LSIL），the positive rate was 3% （21 cases），the positive rate of high squamous intraepithelial lesion （HSIL）was 1.1%（8 cases），and the positive rate of squamous cell carcinoma（SCC）was 0.3%（2 cases）.The positive rate of HPVDNA detection was 7.4%（52 cases），and the positive rate of colposcopy was 9.6%（67 cases）.In the subsequent pathological biopsy，the CINⅠ detection rate was 2.9%（20 cases），the CINⅡ detection rate was 1.9（13 cases），the CINⅢdetection rate was 1.0%（7 cases），and the invasive cancer detection rate was 0.6（4 cases）.HPV-DNA positive CINⅠdetection rate was 2.0%（14 cases），CINⅡ detection rate was 1.3%（9 cases），CINⅢ detection rate was 0.6%（4 cases）and invasive cancer detection rate was 0.3%（2 cases）.The accuracy of pathological results of TCT and HPV combined with colposcopy was higher than that of conventional TCT combined with HPV，the difference was statistically significant（P＜0.05）.There was no significant difference between the two cases of invasive carcinoma（P＞0.05）.TCT had the highest sensitivity，followed by colposcopy，and HPV-DNA typing had the lowest sensitivity;the colposcopic specificity was the highest，followed by HPV-DNA typing，and TCT was the lowest.
Conclusion
The combined examination of TCT，HPV-DNA typing and colposcopy can effectively improve the positive detection rate of cervical lesions.It is an effective screening method for cervical lesions and has important clinical application value.It is worthy of promotion.
2019 Vol. 26 (6): 133-136 [
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73
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137
Clinical significance of four blood coagulation tests and routine blood tests in pregnant women
MA Zhi-jin
Objective
To investigate the clinical significance of blood test and four blood coagulation in pregnant women.
Methods
A total of 200 pregnant women in our hospital from February 2017 to November 2018 were selected as observation group，and 200 healthy non-pregnant women in the same period were selected as the control group.With the blood routine test，the blood test and four blood coagulation test results of the two groups were recorded and compared.
Results
The APTT，PT，and TT in the observation group were lower than those in the control group，and the FIB was higher than those in the control group，the differences were statistically significant（P＜0.05）.The blood routine test results in the observation group were RBC and HGB，PLT and MCV were lower than those in the control group，WBC and RDW were higher than those in the control group，and the differences were statistically significant（P＜0.05）.
Conclusion
The four blood coagulation tests and blood routine tests can effectively evaluate the health status of pregnant women in labor，and reduce the incidence of obstetric accidents，which is worth promoting.
2019 Vol. 26 (6): 137-139 [
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89
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140
Application effect of performance management in operating room nursing management
LIN Xiao-shan
Objective
To explore the application effect of performance management in operating room nursing management.
Methods
From June to September 2016，the performance evaluation team was set up in operating room of our hospital to formulate performance scoring standards.Based on the principle of more pains and more gains，and great salary with excellent work，the nursing staff were divided into five levels of N
0
-N
4
.The coefficient of the difference of the levels was calculated according to the hospital′s standard coefficient of 0.06.Total performance bonus=performance time bonus（70%）+performance score bonus（30%）.The surgical time of performance was personal work time ×grading coefficient.The basic score of performance evaluation was 100 points including medical ethics（8 points），labor discipline（12 points），work attitude（35 points），work skills（40 points），teaching and learning（5 points）.Items of points adding and reducing were also created.The total performance bonus equals to the final total score×performance coefficient.The theoretical and operational assessment results on these staff before and 3-month after the performance management，the work quality score，the satisfaction of the nursing staff on the performance bonus，the satisfaction scores from surgeons and patients were compared.
Results
After the implementation of the performance management program，the theoretical and operational assessment scores，work quality assessment and satisfaction scores of the department staff were all higher than those before with statistical significance （P＜0.05）.After the performance management program，the doctors′and patients′satisfaction scores increased compared with those before the implementation，the differences were statistically significant（P＜0.05）.
Conclusion
The implementation of performance management can mobilize the enthusiasm of the staff of the department，and it also has obvious effects in improving the quality of work in the department and increasing the satisfaction from both doctors and patients，hence promoting the further development of the department.
2019 Vol. 26 (6): 140-142转145 [
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70
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143
Analysis on the realization path of mutual aid and aged care service based on time bank
JIANG Xiu-juan
Pension is an important issue to be solved at present in China，because it concerns the vital interests of the common people and the stability and development of the society.Therefore，China is now actively exploring a variety of pension modes，with the purpose of promoting the improvement of the quality of pension in China.According to the specific analysis at the present stage，China′s pension pressure is gradually increasing，and in the future，such pressure will exist for a long time.However，the current pension mode has no outstanding effect in the solution of such pressure，so a new concept is needed to examine the pension problem.According to the current research，the realization of mutual endowment service plays an important role in solving the endowment problem.Therefore，this paper analyzes the specific realization of mutual endowment service based on the time bank，aiming at providing reference and guidance for the development of new pension modes.
2019 Vol. 26 (6): 143-145 [
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54
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146
Application effect of barcode scanning technology in outpatient adjustment
FAN Wen-sui；CHEN Guang-bin； LIANG Li-mian； ZHENG You-rou
Objective
s To evaluate the effect of barcode scanning technology in outpatient dispensation.
Methods
Prescription dispensing data from the Hospital System （HIS）during the same 3 time periods，from March 1
st
，2015 to September 30
th
，2015 （after the barcode scanning technology was employed）and March 1
st
，2014 to September 30
th
（before the barcode scanning technology was employed）were used for the observation group and the control group.The average waiting time of the two groups in the same three time periods were compared，and the two groups of drug dispensing error rate was compared.
Results
In the three time periods of 10：30-10：59，11：00-11：29，11：30-12：00，the average waiting time between the the observation group （6.20，5.87，6.27 minutes）were shorter than those of the control group（8.36，8.34，8.29 minutes），the differences were statistically significant（P＜0.05）.The dispensing error rate in observation group（0.021‰）was lower than that in the control group（0.099‰），the difference was statistically significant（P＜0.05）.
Conclusion
The application of barcode scanning technology in outpatient dispensation can effectively reduce the dispensing error rate，improve the accurate rate in distributing the drugs and shorten the patients′waiting time.It is worth popularizing and applying.
2019 Vol. 26 (6): 146-148 [
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72
)
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149
Analysis of work stressors of nursing staff in infectious diseases department of our hospital and countermeasures
HUANG Shao-juan
Objective
To explore the work stress source and countermeasures of nursing staff in infectious diseases department of our hospital.
Methods
From February 2016 to April 2018，20 nursing staff of infectious diseases in our hospital were selected as the research group.In the same period，19 non-infectious disease nursing staff were included as the control group.Through the nurses′work pressure scale to understand the two groups of work pressure，and countermeasures were given.
Results
The work stressors of the research group ranked in the order of the number of deaths of infectious diseases patients，the low social status of the nursing staff，the low wages and benefits，the fear of errors in the work，and the small number of nursing staff，including 3 points and 4 points，the proportion was high.The control group has a large workload，worry about errors in work，frequent shifts，overdue care of nursing patients，inadequate support and understanding of nursing managers，and a relatively balanced number of people.The total score of stressors in the study group was higher than that of the control group，the difference was statistically significant（P＜0.05）.
Conclusion
As a nursing manager，it is necessary to pay full attention to the pressure of nursing staff in infectious diseases，and to provide targeted countermeasures according to the pressure source to reduce the pressure of nursing staff and to take care of the best mentality.
2019 Vol. 26 (6): 149-151 [
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76
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152
Clinical application evaluation of automatic warning function in the cardiac remote monitoring system
LIU Yan-yang；DONG Yong-hai；WAN Lin-jing；XU Yong-fei；GUAN Xi-hong
Objective
To explore the clinical application effect of automatic warning function in the cardiac remote monitoring system（CRMS）.
Methods
A total of 2000 patients with arrhythmia who were hospitalized in Jiangxi Provincial People′s Hospital from August 2016 to August 2018 were included in this study.All the patients wore the iHolter，and were monitored 24 hours in real time following the doctors′advice.During the performance，CM1 and CM5 dual channels were used to record the data and automatic alarm，silent mode were performed.Before wearing the iHolter，all patients were examined by conventional 12 leads electrocardiogram.After removing the iHolter，the monitoring data were played back and the diagnostic report was issued.According to the monitoring and storage data，the number of hypothesis warnings and actual warnings was analyzed.The positive rate of arrhythmia between CRMS and conventional 12 leads electrocardiogram was compared.
Results
The effective rate of actual warning in CRMS was 94.76%（2260/2385），which was not statistically significantly different from 93.43%（2091/2238）of hypothesis warning in CRMS（P＞0.05）.The positive rate of CRMS in 2000 patients with arrhythmia was 69.05% （1381/2000），which was significantly higher than that of conventional 12 leads electrocardiogram accounting for 33.75% （675/2000），and the difference was statistically significant（P＜0.05）.Among the different types of arrhythmia patients，the positive rate in CRMS diagnosis of arrhythmia was also significantly higher than that in the conventional 12 leads electrocardiogram，and the difference was statistically significant（P＜0.05）.
Conclusion
The automatic warning function of CRMS is of a high value in disease diagnosis and prevention.
2019 Vol. 26 (6): 152-154 [
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] (
61
)
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13
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155
Clinical application effect of self-made tympanic needle in tympanic membrane puncture for secretory otitis media
XIONG Mei-hua； CAO Run-qin； LI Fen
Objective
To explore the clinical application effect of the self-made tympanic needle in tympanic membrane puncture for secretory otitis media.
Methods
A total of 60 cases of patients with secretory otitis media treated in our department from January 2017 to June 2018 were selected as study objects.According to the random control table method，they were divided into the observation group （n=30）and the control group （n=30）.The observation group was treated with self-made tympanic membrane puncture needle，while the control group was treated with conventional tympanic membrane puncture needle.The operating satisfaction of patients and the occurrence of adverse reactions between the two groups were compared.
Results
The total satisfaction rate of the observation group was 96.7%，which was significantly higher than that of the control group accounting for 73.4%，and the difference was statistically significant（P＜0.05）.There were no external ear canal skin hemorrhage，tympanic membrane and tympanic mucosal hemorrhage in the observation group.One case of ear pain occurred in the observation group，and the total incidence rate of adverse reactions was 3.3%.In the control group，there were 2 cases of external ear canal skin hemorrhage，2 cases of tympanic membrane and tympanic mucosal hemorrhage，and 4 cases of ear pain，and the total incidence rate of adverse reactions was 26.7%.The total incidence rate of adverse reactions in the observation group was significantly lower than that in the control group，and the difference was statistically significant（P＜0.05）.
Conclusion
Compared with conventional tympanic membrane puncture needles，the application of self-made tympanic membrane puncture needle under rigid auricular endoscopy can significantly improve the treatment effect and operational satisfaction of patients，reduce the risk of tympanic membrane and mucosa damage in external auditory canal，prevent the adverse reactions such as pain，which is worthy of clinical promotion and application.
2019 Vol. 26 (6): 155-157转161 [
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] (
71
)
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12
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158
Visualization study on research keywords of medical intelligence institutes
DING Yuan-yuan ；ZHOU Jun
In this study，Cite Space software was used to analyze the hot spots of papers by three provincial medical intelligence institutes with high academic influence from CNKI during 2001-2017，Institute of Medical Information and Chinese Academy of Medical Sciences（IMI）.IMI focused on patents，health services，informatization researches，while Shanghai institute concentrated on health policy，Shangdong institute mainly studied medical library and information science，Sichuan institute pay more attention to statistics and evaluation of health information data.After summarizing research subjects and frontier context of the four institutes in each period，were concluded that traditional businesses such as medical information and journal have gradually become weak.In recent years，health policy research，health informatization and technical assessment have become new research hotspot.
2019 Vol. 26 (6): 158-161 [
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75
)
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162
Empirical study on the relationship between advertising expenditure and business performance in pharmaceutical companies
LI Yu-qing； DENG Xue-lian
In recent years，competition among pharmaceutical companies has strengthened increasingly on account of Chinese pharmaceutical industry development.For the sake of getting an advantageous position in the competition，pharmaceutical companies have increased their investment in advertisement，which displays the advantages and characteristics of products and stimulates the desire to buy.Nowadays，pharmaceutical companies has became prominent advertisement utilizer，but advertising increase the cost of the company，therefore，the relationship between advertising costs and corporate performance needs to be studied.In this study，fifteen pharmaceutical companies were selected as research samples，and the correlation between advertising costs，operating income and net profit from 2012 to 2017 was investigated.It is found that，advertising cost and operating income as well as net profit positively correlated with each other significantly.Advertisement could contribute to increase sales and improve business performance of pharmaceutical conpany.
2019 Vol. 26 (6): 162-165 [
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55
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166
Research on the comprehensive and cohesive learning effect evaluation model of clinical medical students during their internship
SUN Yuan-bo；LI Gui-qin； LI Yue；ZHU Min；SONG Xian-dong
Objective
To explore the best method to evaluate the learning effect of clinical medical students during their internship.
Methods
Altogether 92 students in clinical medicine of Mudanjiang Medical College were selected as teaching objects from July 2013 to June 2018.The students were divided into control groups and observe group according to the random number table method，46 cases in each group.The control group was evaluated with routine teaching effect method，and observe group was evaluated with comprehensive and connected learning effect evaluation model.After the internship，teaching effect was evaluated from three aspects： students′learning situation of theoretical knowledge，comprehensive ability and teachers′evaluation.
Results
In the self-assessment aspect of theoretical knowledge learning，the self-evaluation results of extended knowledge in the observe group were higher than those of control group（P＜0.05）.In the self-assessment aspect of comprehensive ability，the scores of observe group were higher than those of control group（P＜0.05）.In the aspect of teacher evaluation and in the second half of the internship period，the favorable rate of the observe group was higher than that of control group，the differences were statistically significant（P＜0.05）.
Conclusion
In the practice stage，according to comprehensive and connected learning effect evaluation model to evaluate the effect of internship，which can effectively improve teaching effect of clinical medical students.
2019 Vol. 26 (6): 166-168 [
Abstract
] (
78
)
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169
Application and optimization of network multimedia medical teaching in general surgery
ZHENG Ya-min ；WANG Yue-hua；LI Fei
Multimedia and network technology progress promoted the development of medicine teaching.Multimedia web-based learning stimulated students′interest and improve students learning initiative through intuitive and flexible form.It also can reduce the burden of teachers，improve teaching efficiency and become an important part of clinical medical teaching in recent years.But there are many problems about current network multimedia teaching in general surgery，such as dispersive network medical resources，irregular forms，lack of systematicness and relatedness，insufficient of interaction between teachers and students，failure of supervision and feedback.Optimization of multimedia teaching need multidisciplinary professionals to participate and improve clinical teaching system in many aspects，include aggregate contents of network database，classify teaching materials，improve network interactive function，and improve learning and evaluation method.
2019 Vol. 26 (6): 169-171 [
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70
)
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172
Exploration and practice of pharmaceutical laboratory management and drug use reform based on the cultivation of student′s professional quality
JI Yao-hua；LI Xin； BAI Xue-jie
This research is targeted on the traditional experimental teaching management mode，and the experimental teacher has a strong work intensity，which is not conducive to the current situation of student′s professional quality cultivation.This study normalizes and innovates the management，use mode of experimental instruments and drugs in the experimental process.The mode is well-ordered and scientific placement of experimental products，and process management of experimental products in rational use，and experimental process with strengthening management to the individuals.Besides，the study analyzes the pros and cons before and after this reform.Before the reform，the intensity of the work was strong for both laboratory technicians and experimental teachers，which were not good for the formation of scientific work style and cultivation of professional quality of students.After the reform，the work intensity of the laboratory technicians and the experimental teacher is alleviated，which helps to cultivate student′s management ability，reduce the hidden dangers of the laboratory，cultivate student′s safety awareness and conservation awareness，and develop a good working habit，forster student′s rigorous and serious working attitude，and enhance their sense of post responsibility.
2019 Vol. 26 (6): 172-175 [
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67
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176
Application effect of scenario simulation training plus audio-visual approach in the emergency room nurses′standardized training on the ear thermometer
WANG Ling-ling
Objective
To discuss the clinical value of scenario simulation training plus audio-visual approach in the standardized training on the ear thermometer.
Methods
A total of 30 nurses in the emergency room of our hospital on March，2018 were selected as the subjects，and randomly assigned to two groups，with 15 cases each group.The control group was treated with the conventional training mode on the theoretical knowledge and operating skills.The study group was treated with the scenario simulation training plus audio-visual approach.The nurses′awareness rate on the ear thermometer knowledge and pass rate of skill operation examinations as well as teaching results were compared.
Results
The nurses′related knowledge awareness rate and examination pass rate in the study group was 100.00%and 93.33%，which was significantly higher than those in the control group（73.33%，66.67%），the differences were statistically significant（P＜0.05）.The scores of theoretical knowledge，skill operation，problem analysis ability and emergency processing ability in the study group were significantly higher than those in the control group，the difference was statistically significant （P＜0.05）.
Conclusion
The scenario simulation training plus audio-visual approach can remarkably improve the standardized training levels and the nurses′comprehensive quality.It is worthy of clinical application and promotion.
2019 Vol. 26 (6): 176-178 [
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] (
62
)
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179
Application effect of perioperative nursing teaching resources combined with flipped classroom used in experimental teaching of surgical nursing
PANG Xiao-li；GUO Zhi-qiang ；GUO Li-yan ；DENG Ying
Objective
To study the application effect of perioperative nursing teaching resources combined with flipped classroom used in experimental teaching of surgical nursing course.
Methods
Class 1 and Class 2 of Grade 2016 Nursing Junior College in our school were selected as the subjects，and randomly divided into observation group（n=75）and control group（n=51）.During the experiment teaching，the observation group was teached by combined self-built teaching resources with flipped classroom，while the control group used traditional teaching methods.The teaching effects were compared between the two groups.
Results
The theoretical examination results，practical examination results and evaluation scores of quality in the observation group were higher than those in control group，and the differences were statistically significant（P＜0.05）.
Conclusion
The use of teaching resources combined with flipped classroom in experimental teaching can stimulate the learning interest of nursing students and improve quality of teaching and teachers′teaching ability.
2019 Vol. 26 (6): 179-182 [
Abstract
] (
63
)
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8
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183
Analysis of clinical teaching methods for postgraduates of critical care medicine
LIU Ying；LI Jing；ZHAO Yi；CHEN Shang-yu； CHEN Wen-xiu ；LIU Han
Critical care medicine is a comprehensive subject which studies the occurrence，development of critical illness and its diagnosis and treatment.The clinical teaching base of critical care medcine is intensive care unit（ICU）.The clinical teaching of ICU focuses on the"pathophysiology-oriented"teaching method，to stabilize patients′vital signs and pathophysiological disorders，and strive for time to tide over the most critical situation.By analyzing the current situation of postgraduate education in critical care medicine in colleges and universities.This paper expounds the need to adapt to the new situation in training methods，and emphasizes the use of"pathophysiology-oriented"mode of teaching，so as to improve the rescue level and operational skills of postgraduates in critical care medicine.It can provide a reference model for professional postgraduates in teaching methods.
2019 Vol. 26 (6): 183-186 [
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84
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187
Diagnosis and treatment and pharmaceutical care analysis of 1 case of sudden deafness with diabetes and hypertension
HE Lan； PENG Jiang-qiu
By taking part in the medical treatment of diabetes，the clinical pharmacists analysiec the drug use of the glucocorticoid，regulating blood glucose，blood lipid，blood pressure，improving microcirculation and subsequent symptomatic treatment drugs in 1 cases of sudden deafness with diabetes mellitus and hypertension.The clinical pharmacists developed and implied individualized pharmaceutical care for patient′s condition and at the same time，according to the clinical efficacy of drugs to adjust the pharmaceutical care program.Using glucocorticoid and glycemic control drugs as the starting point，the clinical pharmacists carried out pharmaceutical care for the whole patient and and find and solve problems in drug therapy in time to ensure rational，safe and effective drug use，and improve clinical cure rate.The clinical pharmacists have accumulated the experience of medical care in patients with sudden deafness associated with diabetes and hypertension in treatment of sudden deafness，regulating blood glucose，blood pressure and other drugs in the practice of clinical drug therapy.Providing"patient oriented"clinical pharmacy，formulation and analysis of individualed treatment plan are important for clinical pharmacists in the participation of clinical service.Given to patients with pharmaceutical care，not only can doctors and patients were given with drug treatment pharmaceutical professional help，but also the patients can have a treatment with a stable emotion，and which could enhance patients′confidence，increase patient satisfaction，increase medication compliance，reflect the value of clinical pharmacists.
2019 Vol. 26 (6): 187-189 [
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63
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190
Analysis of listeria infection in 2 neonates
LI Yu-ping；WANG Min
Neonatal listeria infection is one of the important causes of neonatal abortion，premature birth and even stillbirth.Treatment of this disease is very difficult，with many sequelae and poor prognosis.In addition，there is no direct and effective method to cure neonatal listeria infection.By analyzing the etiology and understanding the pathogenesis，we can avoid contact and pay attention to prevention.Through clinical manifestations，early detection can be achieved，missed diagnosis and misdiagnosis can be avoided，and effective treatment can be summarized to improve the prognosis of this disease.In this paper，2 cases of neonatal infection with listeria were studied in the pediatric department of yichang central people′s hospital，and the clinical manifestations，laboratory examination and treatment were analyzed to improve the prognosis.
2019 Vol. 26 (6): 190-192 [
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73
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193
Application of focused solution model psychological intervention in young patients with cerebral infarction
ZOU Qin-wei；LIU Hua-zhi；LIU Mei-qing ；LAI Hong； MENG Li-min； WU Jian-fen ；XIE Gui-lan
Objective
To exploreapplication of focused solution model psychological intervention in young patients with cerebral infarction.
Methods
According to the date of admission，80 young stroke patients，which were under the treatment in our hospital from May to October 2017，were randomly divided into two groups，the experimental group（even date）and control group（singular date），40 cases in each group.The control group was received conventional treatment，while the experimental group was exposed to psychological intervention using solution focused approach based on conventional treatment.The patients in two groups were evaluated using the Hamilton depression scale （HAMD）and the improved Barthel score after three days，1 and 6 months，respectively.
Results
There was no significant difference in HAMD score between the two groups before intervention （P＞0.05）.The scores of HAMD in the two groups were lower than those before intervention 3 days，1 and 6 months after intervention，and the scores in the experimental group were lower than those in the control group （P＜0.05）.There was no significant difference in the modified Barthel score between the two groups before intervention（P＞0.05）.The modified Barthel score of the two groups 3 days after intervention，1 and 6 months after intervention was higher than that of the control group （P＜0.05）.
Conclusion
Psychological intervention using solution focused approach can obviously alleviate the depression and dysfunction of young stroke patients，and improve the recovery and quality of life of patients with functional disorders.
2019 Vol. 26 (6): 193-195 [
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69
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196
Effect of continuous nursing on compliance of antiviral therapy and quality of life of discharged patients with hepatitis C
ZHOU Qiu-hong
Objective
To explore the effect of continuous nursing on compliance of antiviral therapy and quality of life of discharged patients with hepatitis C.
Methods
A total of 102 patients with hepatitis C admitted to our hospital from February 2015 to August 2016 were enrolled in the study，and they were divided into the control group （50 cases）and the observation group （52 cases）according to random number table method.The patients in the control group were treated with traditional discharge education，and the observation group was took continuous nursing.After 6 months of nursing intervention，the quality of life and compliance of antiviral treatment between the two groups were compared.
Results
After nursing intervention，the incidence of symptoms such as hair loss and insomnia，weight loss，anxiety，skin erythema，or hard knot were significantly lower than those of the control group，the differences were statistically significant（P＜0.05）.The rate of compliance in the observation group （including regular reexamination and medication on time，reasonable diet，smoking cessation and abstinence and moderate exercise）were significantly higher than those in the control group （P＜0.05）.
Conclusion
The application effect of antiviral treatment and continuing nursing on discharged patients with hepatitis C is remarkable.It can effectively improve the quality of life and compliance of drug treatment，and promote the rehabilitation of patients.It is worth popularizing.
2019 Vol. 26 (6): 196-198 [
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74
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199
Application effect of continuing nursing on the growth and neurodevelopment at infancy stage in premature infants with extremely low birth weight
LI Hai-xiang ；XIONG Feng-xia ；LIU Shu-xia； WANG Xia ；LI Xiao-cui
Objective
To investigate the effect of continuous nursing on the growth and neurodevelopment at infancy stage in premature infants with extremely low birth weight.
Methods
Eighty infants with extremely low birth weight admitted to our hospital from March 2012 to March 2017 were selected.They were divided into the control group （n=40）and the observation group （n=40）according to random number table method.In the control group，routine care was used，while in the observation group，continuing nursing intervention was added on the basis of routine care.The body weight at o，6，and 12 months old were collected for growth and development evaluation.The neurodevelopment from five aspects including language and gross motor using Pediatric Neuropsychological Development Scale for 0-6 years old was evaluated.
Results
After continuing nursing in the observation group，the length and body weight of the children at 6 and 12 months old were both superior to those of the control group （P＜0.05）.There was no significant difference in head circumference（P＞0.05）.In the observation group，after the continuing nursing，the scores of the gross motor，language，fine movements，adaptability，and social ability were all higher than those of the control group （P＜0.05）.The mean value of developmental quotient of the children in the observation group at 3，6，and 12 months old was better than that of the control group （P＜0.05）.
Conclusion
Continuing nursing is beneficial to promote the growth and neurodevelopment of premature infants with extremely low birth weight，which is worthy of clinical application.
2019 Vol. 26 (6): 199-201转204 [
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67
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202
Effect of whole-course nursing intervention mode on stages of labor of painless delivery
YE Xiao-dan； MO Yan-hong； LIN Shan-shan
Objective
To investigate the effect of whole-course nursing intervention mode on the stages of labor of painless delivery.
Methods
A total of 522 puerperae undergone painless delivery were enrolled in our hospital from January to December in 2017.They were divided into two groups according to the random number table method，261 cases in each group.In control group，routine nursing intervention was used，while in experimental group，a wholecourse nursing intervention mode was adopted.The first stage of labor，the second stage of labor，and the third stage of labor，as well as maternal satisfaction were recorded and compared between the two groups.
Results
In the experimental group，the first stage of labor，the second stage of labor，the third stage of labor，and the total labor time were were all shorter than those in the control group （P＜0.05）.The satisfaction of the experimental group was 100.0%，higher than that of the control group accounting for 80.8%，with statistical significance （P＜0.05）.
Conclusion
The wholecourse nursing intervention mode can effectively shorten the labor stages of painless delivery，reduce the pain of the mother during childbirth，improve the maternal satisfaction，which is beneficial to the health and safety of the mother and the newborn and is worthy of promotion.
2019 Vol. 26 (6): 202-204 [
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69
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The study of effect of clinical nursing pathways on postoperative rehabilitation of patients with gastric cancer and the influences on quality of life
LUO Zhang-jian
Objective
To study the effect of clinical nursing pathways on postoperative rehabilitation of patients with gastric cancer and the influences on quality of life.
Methods
A total of 80 patients with gastric cancer after operation in our hospital from February 2014 to February 2015 were selected.According to a random number table method，they were divided into two groups，40 patients in each group.Routine examination and treatment were performed in each group.The control group were followed up for routine nursing care.The study group was treated with clinical nursing pathways.The anesthesia time，time of hospitalization，length of stay and overall physical and physical function after nursing，physical function，physical pain，vitality，social function，emotional function，mental health and other quality of life scores were compared.
Results
After study，the duration of anal exhaust，time of bed movement and hospital stay in the study group were significantly shorter than that in the control group （P＜0.05）.The overall health，physiological function，physiological function，physical pain，vitality，social function，emotional function，mental health and other quality of life scores of the study group were significantly higher than those of the control group，the differences were statistically significant（P＜0.05）.
Conclusion
The clinical nursing path pattern can significantly shorten the hospital stay and improve the postoperative recovery of the patients.It can obviously improve the quality of life of patients and improve the patient′s satisfaction.It is of clinical value and worthy of promotion.
2019 Vol. 26 (6): 205-207 [
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70
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Application effect of high quality nursing in patients with chronic schizophrenia
LIU Qun
Objective
To investigate the effect of high quality nursing in patients with chronic schizophrenia.
Methods
A total of 60 patients with chronic schizophrenia admitted to our hospital from October 2014 to October 2017 were enrolled.According to different nursing methods，they were divided into observation group and control group，30 cases in each group.In the control group，routine nursing was used，while in the observation group，on the basis of routine nursing，high quality nursing was added.The mental recovery，psychological condition and total nuring satisfaction were compared between the two groups.
Results
The brief psychiatric rating scale （BPRS）and nurses′observation scale for inpatient evaluation（NOSIE）scores of the two groups after nursing were both lower than those before nursing.The selfrating depression scale （SDS）and self-rating anxiety scale （SAS）scores were significantly lower than those before the nursing with statistical significance（P＜0.05）.The BPRS and NOSIE scores of the observation group after nursing were both lower than compared with those in the control group.The SDS and SAS scores after nursing were both lower than those of the control group with statistical significance（P＜0.05）.
Conclusion
Application of high quality nursing in patients with chronic schizophrenia can significantly improve the mental indicators of patients as well as the SDS and SAS scores，and increase the total nursing satisfaction compared with routine nursing，which is worthy of promotion in clinical practice.
2019 Vol. 26 (6): 208-210 [
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75
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211
Effect of comprehensive rehabilitation nursing on wound healing，complications and quality of life in patients with deep burn
YU Hua-mei
Objective
To study the influence of comprehensive rehabilitation nursing on wound healing，complications and quality of life in patients with deep burn.
Methods
A total of 74 patients with deep burns who admitted to our hospital from February 2016 to February 2018 were enrolled in the study.They were divided into study group and control group according to random number table method，37 patients in each group.Patients in the study group were provided with comprehensive rehabilitation nursing，while the control group，they were treated with routine care.The wound healing，complications and quality of life were compared between the two groups.
Results
After the comprehensive rehabilitation nursing，the wound healing time of the study group was shorter than that of the control group with significant difference （P＜0.05）.The total incidence of complications of the study group was lower compared with that of the control group with statistical difference （P＜0.05）.The patients in the study group had higher quality of life score than those of the control group with statistical significance （P＜0.05）.
Conclusion
For patients with deep burns，comprehensive rehabilitation care can speed up the healing of wound，greatly reduce the incidence of complications and improve the quality of life，which is worthy of promotion in clinical practice.
2019 Vol. 26 (6): 211-213 [
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66
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Application effect of high-quality nursing in total hip replacement
WANG Bao-ying；HUANG Mei-hua；FENG Huan-fang
Objective
To explore the value of high-quality nursing in total hip replacement and provide theoretical basis for clinic.
Methods
A total of 60 patients who accepted total hip replacement in our hospital from June 2014 to June 2017 were selected as study subjects and divided into control group and observation group according to the admission sequence，30 cases in each group.Patients in the control group were treated with routine operation nursing，while those in the observation group were treated with high-quality nursing cooperation.Total satisfaction rate of nursing，duration of operation and intraoperative blood loss were observed and compared between the two groups.
Results
The duration of operation of the observation group was shorten than that of the control group，while intraoperative blood loss was less than that in the control group，the differences were statistically significant（P＜0.05）.The total satisfaction rate of nursing of the observation group was 93.33%，which was significantly higher than that in the control group （73.33%）（P＜0.05）.
Conclusion
High-quality nursing in total hip replacement can improve total satisfaction rate of nursing， shorten the duration of operation and reduce intraoperative blood loss，which is benefit to improve the patients′compliance.It is worthy to be applied generally in clinical practice.
2019 Vol. 26 (6): 214-216 [
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66
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Application effect of perioperative nursing intervention in patients with appendectomy
LI Yi；LIU Ya-ru
Objective
To explore the effect of perioperative nursing intervention in patients with appendectomy.
Methods
Patients with appendicitis who treated in our hospital from January 2015 to May 2017 were selected as subjects and divided into control group（n=20）and study group（n=20）according to the different perioperative nursing mode.The control group was given the routine nursing mode，and the study group was additionally given nursing intervention on the basis of routine nursing.The complication rate，nursing satisfaction，anal exhaust time，bowel sound recovery time and postoperative pain degree were compared between the two groups.
Results
The total perioperative complication rate of the study group was 10.00%，lower than that of the control group（40.00%）（P＜0.05）.The nursing satisfaction of the study group was 100.00%，little higher than that of the control group （90.00%）（P＞0.05）.The anal exhaust time and bowel sound recovery time of the study group were shorter than those of the control group，and the postoperative pain degree score was lower than that of the control group，the differences were statistically significant（P＜0.05）.
Conclusion
Perioperative nursing intervention is effective in patients with appendectomy and it is worthy to be promoted.
2019 Vol. 26 (6): 217-219 [
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69
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Effect of full-time accompanying midwifery combined postural guidance on delivery methods and quality of life
RAO Wen-zhen； GUO Liang-jing
Objective
To investigate the effect of the combined method of full-time accompanying midwifery and postural guidance on maternal delivery and quality of life during childbirth.
Methods
A total of 200 puerpera who expected labor in our hospital from September 2016 to December 2017 were selected as the study subjects and randomly divided into control group and observation group，100 cases in each group.The control group was given regular delivery guidance.The observation group was given the combined method of full-time accompanying midwifery and postural guidance.The amount of bleeding，quality of life scores，and satisfaction were compared between the two groups.
Results
The natural delivery rate in the observation group was higher than that in the control group.Vaginal assisted delivery rate and cesarean section assisted delivery rate were lower than those in the control group（P＜0.05）.The amount of bleeding in the observation group was less than that in the control group（P＜0.05）.The scores of quality of life such as the maternal physical health，mental health and social health in the observation group were higher than those in the control group，the differences were statistically significant（P＜0.05）.
Conclusion
The combined midwifery mode of fulltime accompanying midwifery and postural guidance can significantly improve the maternal natural delivery rate and reduce birth bleeding，and also has a positive effect on improving maternal quality of life and satisfaction.
2019 Vol. 26 (6): 220-222 [
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66
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223
Characteristics and nursing strategies of urban vagrant psychotics patients
LIANG Li-fen；OUYANG Shao-wei；LI Gui-yun
Objective
To investigate the characteristics and nursing strategies of urban vagrant patients with mental illness.
Methods
From October 2016 to October 2017，50 urban wandering psychiatric patients admitted to our hospital were used as observation group.Another batch of 50 general psychiatric patients in the same period was selected as control group.The physical disease，admission methods，mental status at the time of admission，analysis of first aid and nursing methods were compared in the two groups.
Results
The incidence of combined trauma，skin ulceration and other physical diseases in the observation group was significantly higher than that in the control group，while the rate of free physical disease was significantly lower than that in the control group （P＜0.05）.The proportion of sending to hospital by policemen or from emergency centers was significantly higher than that of the control group，while the percentage of patients transferred from other hospitals，or by their family members or units was lower compared with that in the control group，with statistical differences （P＜0.05）.In the observation group，the incidence of behavioral disorders，hurting others， and destruction was higher than that of the control group， and self-care was worse compared with those in the control group， the cooperation rate was lower，which were displayed statistical significance （P＜0.05）.
Conclusion
Urban wandering patients with mental illness need standardized first aid and nursing by following the principle of first life-saving and then disease treatment.Identify life-threatening physical diseases，together with targeted nursing measures，medical staff needs more patience and efforts.
2019 Vol. 26 (6): 223-225转228 [
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62
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Clinical nursing pathway in the treatment of patients with acute cerebral infarction by intravenous thrombolytic therapy with Alteplase
FANG Hai-xia
Objective
To explore the clinical application of clinical nursing pathway in the treatment of patients with acute cerebral infarction by intravenous thrombolytic therapy with Alteplase.
Methods
A total of 30 patients with acute cerebral infarction admitted to our hospital from July 2017 to August 2018 were selected as study objects，and divided into control group （15 cases）and observation group （15 cases）according to the double-blind randomization method.Routine nursing methods were adopted in the control group，and clinical nursing path method was adopted in the observation group.The scores of self-depression scale（SDS），self-rating anxiety scale（SAS），National Institute of Health stroke scale（NIHSS）and Barthel index were compared between the two groups.
Results
There were no significant differences in the scores of SDS and SAS between the two groups before treatment（P＞0.05）.The scores of SDS and SAS in the observation group were lower than those in the control group（P＜0.05）.The NIHSS score of the observation group was lower than that of the control group （P＜0.05）.The Barthel index of the observation group was higher than that of the control group （P＜0.05）.
Conclusion
The clinical nursing pathway is effective in the treatment of patients with acute cerebral infarction by intravenous thrombolytic therapy with Alteplase.It can not only improve the psychological state of patients，reduce their neurological deficits，but also enhance their daily living ability.It is worthy of clinical application.
2019 Vol. 26 (6): 226-228 [
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70
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Clinical effect of predictive nursing in prevention of neonatal hemolytic disease complicated with jaundice
XIA Yu-jie； LUO Jia
Objective
To analyze the effect of preventive jaundice complications in children with neonatal hemolytic disease.
Methods
A total of 50 neonates with hemolytic hemorrhage treated in our hospital from January 2016 to July 2018 were selected.They were randomly divided into control group and intervention group，25 cases in each group.The control group was used routine care，and the intervention group was used predictive care，to observe the nursing effects of the two groups.
Results
After the predictive nursing intervention，the satisfaction of nursing in the intervention group was higher than that in the control group，and the improvement of serum bilirubin level was better than that of the control group，and the differences were statistically significant（P＜0.05）.The incidence of jaundice in the intervention group was lower than that in the control group， and the difference was statistically significant（P＜0.05）.
Conclusion
Predictive nursing intervention for children with neonatal hemolysis can reduce the incidence of jaundice complications in children，and can improve the satisfaction of nursing services，which is worthy of popularization and application.
2019 Vol. 26 (6): 229-231 [
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59
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The effect of human-based nursing on the maternal status of advanced pregnancy-induced hypertension and its psychological status
XIAO Li-ying
Objective
To explore the effect of human-based nursing on the application of high-grade pregnant women with high pregnancy and its impact on psychological status.
Methods
A total of 124 elderly women with high pregnancy-induced hypertension who admitted to our hospital from April 2017 to April 2018 were enrolled in the study.They were divided into control group（n=62）and experimental group（n=62）according to random number table method.The control group was received routine care，and basic care on the basis of this，the experimental group was received pedestrian-based nursing and observed and compared the nursing effects and psychological status of the two groups.
Results
The incidence of pre-eclampsia and eclampsia in the experimental group was lower than that in the control group.The Apgar score of the newborn was higher than that of the control group，and the differences were statistically significant（P＜0.05）.The self-rating anxiety scale（SAS）after care in the two groups and self-depression scale（SDS）scores were lower than those before treatment，and the experimental group was lower than that in the control group，the differences were statistically significant（P＜0.05）.
Conclusion
The application of human-based care in elderly women with high pregnancy-induced hypertension can effectively prevent and reduce the pre-eclampsia，incidence of eclampsia，improve bad mood，improve the quality of life of newborns，and have clinical adoption and promotion value.
2019 Vol. 26 (6): 232-234 [
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73
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Effect of psychological nursing intervention on maternal pregnancy outcomes and postpartum depression
BI Yi
Objective
To investigate the effect of psychological nursing intervention on maternal pregnancy outcomes and postpartum depression.
Methods
A total of 64 pregnant women from May 2017 to June 2018 were selected as study subjects.According to the different nursing methods，they were divided into control group and observation group，32 cases in each group.In the control group，routine care was used，while in the observation group，based on this operation，strengthened psychological nursing intervention was adopted.The pregnancy outcomes，postpartum depression and satisfaction were compared between the two groups.
Results
The amount of bleeding 2 hours after birth in the observation group was，less than that of the control group （P＜0.05）.The labor time was shorter than that of the control group（P＜0.05）.The natural delivery rate was higher than that of the control group with statistical significance（P＜0.05）.There was no significant difference in neonatal asphyxia between the two groups（P＞0.05）.The postpartum depression score in the observation group was lower than that in the control group with statistical difference （P＜0.05）.The total satisfaction of the observation group was 100.00%，higher than that of the control group（81.25%），with significant difference （P＜0.05）.
Conclusion
The effect of psychological nursing intervention in pregnant women is favorable，which can effectively improve pregnancy outcomes and avoid postpartum depression.
2019 Vol. 26 (6): 235-237 [
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78
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Application effect of comfortable nursing in perioperative period of breast cancer patients
CHEN Ling
Objective
To explore the effect of comfort nursing in perioperative period of breast cancer.
Methods
A total of 80 cases with breast cancer surgery were enrolled in our hospital from March 2016 to June 2018 and randomly divided into two group，40 cases in each group.The observation group were performed the comfort nursing，and the control group were received routine nursing.After the patients were discharged from the hospital，they were followed up for 1 month by telephone.The effective rate after treatment was compared between the two groups.The Piper cancer fatigue scale （PFS）scores after intervention and the changes of KPS and SF-36 scores after intervention were compared.
Results
One month after intervention，the effective rate in the observation group was higher than that in the control group（P＜0.05）.The scores of PFS scores in the observation group were significantly lower than that in the control group （P＜0.05）.The KPS and SF-36 scores in the observation group after intervention were significantly higher than that in the control group （P＜0.05）.
Conclusion
The implementation of comfortable nursing intervention for breast cancer patients can improve the clinical treatment effect and reduce cancer fatigue，so it can improve the life quality.
2019 Vol. 26 (6): 238-240 [
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76
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Application effect of nurse-patient communication in nursing care of elderly diabetic patients
SUN Min； LYU Zhong-yan； WANG Li；ZHANG Hong-yu
Objective
To study the application effect of nurse-patient communication in nursing care of elderly diabetes patients.
Methods
Altogether 76 elderly patients with DM admitted to our center from April 2016 to April 2018 were selected as the research objects and randomly divided into two groups.Among all the patients，38 were taken as control group and treated with routine nursing，the remaining 38 patients were taken as observation group and treated with additional nurse-patient communication on the basis of routine nursing.The changes of psychological state and nursing satisfaction were compared between the two groups.
Results
According to self-rating anxiety scale （SAS）and self-rating depression scale （SDS），the psychological status of the two groups was evaluated.Before nursing，there was no statistically significant difference in SAS and SDS scores between the two groups（P＞0.05）.After nursing，the SAS and SDS scores of the observation group were lower than those of the control group，with statistical difference（P＜0.05）.The nursing satisfaction rate of the observation group was higher than that of the control group，with statistical difference （P＜0.05）.
Conclusion
Strengthened communication between nurses and patients in nursing care of elderly diabetes can improve patients′anxiety，depression and other negative emotions and increase their nursing satisfaction，which is worthy of popularization and application.
2019 Vol. 26 (6): 241-243 [
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68
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Effect of high quality perioperative nursing on cataract patients undergoing phacoemulsification combined with intraocular lens implantation
HU Li-ru ；DENG Ting
Objective
To explore the perioperative nursing methods and effects of phacoemulsification combined with intraocular lens implantation.
Methods
A total of 500 cases of cataract patients treated with phacoemulsification and intraocular lens implantation in our hospital from September 2016 to September 2017 were selected as subjects，and all the patients were divided into experimental group and control group according to random number table method，250 cases in each group.The patients in the control group were received routine perioperative nursing，and the patients in the experimental group were received high quality perioperative nursing，the difference of two groups of nursing satisfaction，the rate of operation success，the incidence of complications and the self-care ability of life between the two groups were campared.
Results
The rate of success，satisfaction and quality of life of the patients in the experimental group were higher than those in the control group （P＜0.05）.The incidence of complications in the experimental group was lower than that of the control group，with significant difference（P＜0.05）.
Conclusion
The patients with high quality perioperative nursing have significant advantages，which can obviously improve the success rate of surgical treatment，improve the patient′s nursing satisfaction，improve the quality of life and reduce the incidence of complications.
2019 Vol. 26 (6): 244-246 [
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Application effect of early rehabilitation nursing in the nursing of stroke patients with hemiplegia
JI Yuan-yuan； LYU Hui-lan； HE Xiao-li
Objective
To study the effect of early rehabilitation nursing on the nursing of stroke patients with hemiplegia.
Methods
Eighty-seven stroke patients with hemiplegia who admitted to our hospital from January 2016 to February 2018 were selected and randomly divided into two groups.In experimental group（n=44），routine nursing+early rehabilitation nursing was adopted，while in control group （n=43），routine nursing alone was performed.The Fugl-Meyermotor scale（FMMS）score，the modified Bartherl score（MBI），the quality of life（QOL）score，and the complications were compared.
Results
There were no significant differences in FMMS，MBI and QOL score between the two groups before treatment（P＞0.05）.After treatment，the FMMS，MBI and QOL score of the two groups were higher than those before treatment.These indexes in the experimental group were higher than those of the control group with statistical significance（P＜0.05）.The total incidence of complications in the experimental group was lower than that the control group，with significant difference （P＜0.05）.
Conclusion
Early rehabilitation nursing can significantly enhance the exercise ability of stroke patients with hemiplegia，improve the quality of life，and reduce complications，which can be clinically promoted.
2019 Vol. 26 (6): 247-249 [
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77
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Application effect of humanistic care in perioperative period of breast cancer patients
WANG Ying
Objective
To investigate the effect of humanistic care on the self-care ability of patients with breast cancer during perioperative period.
Methods
A total of 126 patients with breast cancer admitted to our hospital from July 2015 to September 2017 were enrolled.They were divided into two groups according to random number table method，63 cases in each group.In study group，perioperative humanistic care was adopted，while in control group，perioperative regular nursing was used.The self-care ability and complications of the two groups were compared in the two groups.
Results
After the intervention，the scores of self-responsibility，self-concept，self-care skills，health knowledge and the total self-care ability of the study group were higher than those of the control group （P＜0.05）.The total incidence of complications of the study group was 6.35%（4/63），lower than that of the control group accounting for 19.05%（12/63），with statistical significance （P＜0.05）.
Conclusion
For patients with breast cancer，humanistic care adopted during the perioperative period can obtain a remarkable effect.
2019 Vol. 26 (6): 250-252 [
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