| ［1］ |
Moshe SL，Albala BJ，Ackermann RF，et al.Increased seizure susceptibility of the immature brain［J］.Brain Res，1983，283（1）：81-85.
|
| ［2］ |
Rattani A，Lim J，Mistry AM，et al.Incidence of epilepsy and associatedriskfactorsinperinatalischemicstrokesurvivors［J］.Pediatr Neurol，2018，S0887-8994（18）：30 497-30 501
|
| ［3］ |
Gursoy S，Ercal D.Diagnostic approach to genetic causes of early-onset epileptic encephalopathy［J］.J Child Neurol，2016，31（4）：523-532.
|
| ［4］ |
Baram TZ，Schultz L.Corticotropin-releasing hormone is a rapid and potent convulsant in the infant rat［J］.Brain Res Dev Brain Res，1991，61（1）：97-101.
|
| ［5］ |
Wulsin AC，Solomon MB，Privitera MD，et al.Hypothalamicpituitary-adrenocortical axis dysfunction in epilepsy ［J］.Physiol Behav，2016，16（6）：22-31.
|
| ［6］ |
Ehlers CL，Henriksen SJ，Wang M，et al.Corticotropin releasing factor produces increases in brain excitability and convulsive seizures in rats［J］.Brain Res，1983，278（1-2）：332-336.
|
| ［7］ |
Piekut DT，Phipps B.Increased corticotropin-releasing factor immunoreactivity in select brain sites following kainate elicited seizures［J］.Brain Res，1998，781（1-2）：100-113.
|
| ［8］ |
Yang XL，Chen B，Zhang XQ，et al.Upregulations of CRH and CRHR1 in the epileptogenic tissues of patients with intractable infantile spasms［J］.Cns Neurosci Ther，2017，23（1）：57-68.
|
| ［9］ |
Racine R.Kindling：the first decade［J］.Neurosurgery，1978，3（2）：234-252.
|
| ［10］ |
周浩.早期母子隔离应激对幼鼠癫痫易感性的影响及其机制的研究［D］.重庆：重庆医科大学，2010.
|
| ［13］ |
王树人.病理生理学［M］.7 版.北京：人民卫生出版社，2008.
|
| ［14］ |
蒋文华，刘才栋.神经系统解剖学［M］.上海：复旦大学出版社，2002：369-377.
|
| ［11］ |
Shang NX，Zou LP，Zhao JB，et al.Association between prenatal stress and infantile spasms：a case-control study in China［J］.Pediatr Neurol，2010，42（3）：181-186.
|
| ［12］ |
Herman JP，McKlveen JM，Ghosal S，et al.Regulation of the hypothalamic-pituitary-adrenocortical stress response ［J］.Compr Physiol，2016，6（2）：603-621.
|
| ［15］ |
Harle G，Kaminski S，Dubayle D，et al.Murine splenic B cells express corticotropin-releasing hormone receptor 2 that affect their viability during a stress response ［J］.Sci Rep-UK，2018，8（1）：143.
|
| ［16］ |
Smith BN，Dudek FE.Age-related epileptogenic effects of corticotropin-releasing hormone in the isolated CA1 region of rat hippocampal slices［J］.J Neurophysiol，1994，72（5）：2328-2333.
|
| ［17］ |
Blank T，Nijholt I，Eckart K，et al.Priming of long-term potentiation in mouse hippocampus by corticotropin-releasing factor and acute stress：implications for hippocampusdependent learning［J］.J Neurophysiol，2002，22（9）：3788-3794.
|
| ［18］ |
Baram TZ，Chalmers DT，Chen C，et al.The CRF1 receptor mediates the excitatory actions of corticotropin releasing factor（CRF） in the developing rat brain：in vivo evidence using a novel，selective，non-peptide CRF receptor antagonist［J］.Brain Res，1997，770（1-2）：89-95.
|
| ［19］ |
Shafia S，Vafaei AA，Samaei SA，et al.Effects of moderate treadmill exercise and fluoxetine on behavioural and cognitive deficits，hypothalamic-pituitary-adrenal axis dysfunction and alternations in hippocampal BDNF and mRNA expression of apoptosis-related proteins in a rat model of post-traumatic stress disorder［J］.Neurobiol Learn Mem，2017，13（9）：165-178.
|
