替加环素治疗耐碳青霉烯类肺炎克雷伯菌效果的Meta分析

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Abstract Objective To systematically evaluate the efficacy of Tegacycline monotherapy and combination therapy in the treatment of carbapenem-resistant Klebsiella pneumonia （CRKP）infections.Methods The clinical studies of Tegacycline in the treatment of CRKP were retrieved from Cochrane Library，Embase，Pubmed，China National Knowledge Infrastructure （CNKI）and China Biology Medicine disc （CBM）by computer from the construction of the library to September 2018.Two reviewers independently retrieved studies according to the inclusion and exclusion criteria，assessed the methodological quality of included trials，and extracted data.The data analysis was performed by Review Manager 5.3 software.The odds ratio （OR）and 95%confidence intervals （CI）were calculated for outcome analysis.Results A total of 9 studies were included in this study.There was no significant difference in the mortality of CRKP infection between Tegacycline monotherapy and other monotherapy（OR=1.07，95%CI=0.63-1.82，P=0.8）.There was no significant difference in mortality among CRKP patients treated with Tigacycline-based combination therapy compared with other drugs combination therapy（OR=1.40，95%CI=0.89-2.21，P=0.15）.Conclusion Both Tigecycline monotherapy and Tigecycline-based combination therapy do not significantly improve the mortality of patients with CRKP infections.This conclusion needs more large sample and high quality clinical randomized controlled trials to confirm.

Key words： Tigecycline Carbapenem-resistant Klebsiella pneumoniae Monotherapy Combination therapy Meta analysis

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	HOU Si-yuan
	TAN Yong-feng
	FENG Xing-huo

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HOU Si-yuan,TAN Yong-feng,FENG Xing-huo. Meta analysis of efficacy of Tigecycline in the treatment of carbapenemresistant Klebsiella pneumoniae infections[J]. 中国当代医药, 2019, 26(6): 64-67.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2019/V26/I6/64

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