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2017 Vol. 24, No. 4
Published: 2017-02-08
 
 
4 Expression and clinical signifance of Pyk2,Twist and E-cadherin in hepatocellular carcinoma
ZUO Kai;XUE Dong;KONG Li;XIA Xiu-liang
Objective To explore the expressions of Pyk2,Twist and E-cadherin in hepatocellular carcinoma and their clinical significance.Methods 80 hepatocellular carcinoma tissues in our hospital from February 2006 to February 2012 were selected as the research objects,and 50 cases of adjacent paracancerous tissues were matched (from the edge of cancer tissue to less than 3 cm).Immunohistochemistry of EnVision was used to detect the expression of Pyk2,Twist and E-cadherin in hepatocellular carcinomas and adjacent paracancerous tissues.The correlation between their expression and pathologic parameters were analyzed by statistics.Results The positive rate of Pyk2 in hepatocellular carcinomas was significantly higher than that in adjacent paracancerous tissues,with significant difference (71.3%vs.12.0%,P＜0.05).Significant differences were also observed in the positive expression rate of Twist between the patients with hepatocellular carcinomas and paracancerous tissues(66.3% vs.6.0%,P＜0.01).The positive rate of E-cadherin in hepatocellular carcinomas was significantly lower than that in adjacent paracancerous tissues(27.5%vs.90.0%, P＜0.01).The positive expression of Pyk2,Twist,E-cadherin was significantly correlated with pathological grade,degreeof differentiation,vascular invasion and clinical TNM stage (P＜0.05).The expression of Pyk2 was positively correlated with the expression of Twist in hepatocellular carcinoma (P＜0.05),the expression of Pyk2 was negatively correlated with the expression of E-cadherin (P＜0.05),and the expression of Twist was negatively correlated with the expression of E-cadherin(P＜0.05).Conclusion Pyk2,Twist and E-cadherin protein expression might be associated with the development, invasion,and metastasis of hepatocellular carcinoma.Pyk2 may play a role during invasion and metastasis of hepatocellular carcinoma by up-regulating the expression of Twist.
2017 Vol. 24 (4): 4-7 [Abstract] ( 164 ) HTML (47 KB)  PDF  (0 KB)  ( 29 )
8 Expression of Smad7 mRNA and NF-κBp65 mRNA and their proteins in primary human hepatocellular carcinoma
WANG Xiao-wei;KANG Kai-fu;LUO Xiao-li
Objective To study the expression of Smad7 and NF-κBp65 in HCC and their relationship.Methods 120 cases of specimen from patients carried surgical resection in the First People′s Hospital of Shunde of Southern Medical University from December 2005 to December 2010 were selected as the research object,including 10 cases of normal hepatic tissues,30 case of cirrhosis,30 cases of hepatitis and 50 cases of HCC.Immunohistochemistry and in situ hybridization were used to detect the changes of Smad7 mRNA and NF-κBp65 mRNA and their proteins expressions in each kinds of hepatic tissues.Results The positive expressions rate of Smad7 mRNA and NF-κBp65 mRNA and their protein in HCC tissues were significantly higher than those in the cirrhosis tissues,hepatitis tissues and normal hepatic tissues,the differences were statistically significant(P＜0.01).The expression of Smad7 mRNA and proteins in cirrhosis tissues were higher than those in normal tissues(χ2=4.043,4.848,all P＜0.05).The expression of NF-κBp65 protein in hepatocellular carcinoma was related to tumor size and the expression of Smad7 protein(χ2=5.592,4.578,all P＜0.05).Conclusion The abnormal expression of Smad7 and NF-κBp65 may be related to the evolution of HCC.
2017 Vol. 24 (4): 8-11 [Abstract] ( 129 ) HTML (47 KB)  PDF  (0 KB)  ( 40 )
12 Effect of Total Flavonoids of Rhizoma Drynariae on BMP-2 protein expression and serum bone gla protein level in rats with osteoporosis
HUANG Song;CHEN Jing-you;GAO Hao
Objective To explore the effect of Total Flavonoids of RhizomaDrynariae on BMP-2 protein expression and serum bone gla protein level in rats with osteoporosis.Methods Osteoporosis model was established by removing rat ovary,and the rats were divided into normal group,sham operation group,model group,total Flavonoids of Rhizoma Drynariae group and Caltrate D Tablet group.In the seventh days after surgery,drugs were used once per day for 12 consecutive weeks.Morphological change of bone tissue in rats was observed by HE staining,and the expression of BMP-2 protein and the level of serum bone gla protein level in the femur of rats in each group was detected by ELISA.Results HE staining indicated that the number,density,distribution,and integrity of bone trabecula in the rats femoral bone tissue in the Total Flavonoids of Rhizoma Drynariae group were superior to those in the model group.The protein expression of BMP-2 in rats femoral bone tissue and the level of serum bone gla protein [(13.469±0.215)pg/ml and (1.61± 0.09)μg/L respectively]was much higher than that in the model group[(5.516±0.119)pg/ml and(0.76±0.22)μg/L respectively](P＜0.05).The protein expression and serum bone gla protein level was close to that in the sham operation group respectively[(15.279±0.211)pg/ml and(1.34±0.17)μg/L](P＞0.05).Conclusion In the treatment of rats with osteoporosis,Total Flavonoids of Rhizoma Drynaria can obtain a great effect.The possible mechanism is through up-regulation of BMP-2 protein in the femoral bone tissue and the level of serum bone gla protein,thus promoting the formation of bone tissue.
2017 Vol. 24 (4): 12-15 [Abstract] ( 155 ) HTML (48 KB)  PDF  (0 KB)  ( 36 )
16 Determination of the content of Notoginsenoside R1,Ginsenoside Rg1and Rb1in Uterus-Repairing Hemostasis Granules by using HPLC
LI Ming
Objective To establish the determination of the content of Notoginsenoside R1,Ginsenoside Rg1and Rb1in Uterus-Repairing Hemostasis Granules by using HPLC.Methods By using the Agilent Eclipse XDB-C18column(250 mm× 4.6 mm),the acetonitrile-water was adopted to perform mobile phase gradient elution at flow rate of 1.0 ml/min;and the detection wavelength was 203 nm.Results The linear scope of Notoginsenoside R1,Ginsenoside Rg1and Rb1ranged from 0.277 to 5.540 μg(r=0.9998),from 0.253 to 5.060 μg(r=0.9998),from 0.262 to 5.230 μg(r=0.9997).The average recovery rate was 89.5%(RSD=2.70%),91.0%(RSD=1.87%)and 90.8%(RSD=1.74%)(n=6).Conclusion As a simple,reproducible and accurate method,it can be used for quality control of pseudo-ginseng in Uterus-Repairing Hemostasis Granules.
2017 Vol. 24 (4): 16-19 [Abstract] ( 175 ) HTML (54 KB)  PDF  (0 KB)  ( 36 )
20 Research progress on the pathogenesis of early-onset severe preeclampsia
HE Yu-e
Early onset severe preeclampsia is featured by early onset,severe condition,rapid progression,and high incidence of maternal complications and fatality rate in perinatal infants,the earlier the onset of it,the pregnancy outcome becomes poorer.Many scholars did quite a lot research on its pathomechanism in order to draft the corresponding measure targeted on the pathogenesis and control the development of disease.Together with the actual situation,the paper briefly reviews the pathomechanism of EOSP.
2017 Vol. 24 (4): 20-22 [Abstract] ( 157 ) HTML (35 KB)  PDF  (0 KB)  ( 29 )
23 Research progress on the relationship between polycystic ovary syndrome and autoimmune diseases
GU Fang-yun;GAO Jin-jin;HOU Li-hui
Polycystic ovary syndrome(PCOS)is the most common female endocrine disorders disease,is a common cause of menstrual disorders and infertility in women of childbearing age.Genetic and endocrine factors play a key role in the pathogenesis of PCOS.Low progesterone levels in patients with PCOS lead to overstimulation of the immune system to produce more estrogen,resulting in a variety of autoantibodies.Different antibodies have been found in PCOS patients,for example,antinuclear antibodies(ANA),anti-thyroid antibodies,anti-sperm antibodies,anti-ovarian antibodies,anti-islet cell antibodies,but these antibodies could affect the long-term treatment of these patients,therefore,different levels of antibodies in patients with PCOS have brought new insights into the personalized treatment of diseases.
2017 Vol. 24 (4): 23-25转41 [Abstract] ( 167 ) HTML (42 KB)  PDF  (0 KB)  ( 39 )
26 Clinical study of Seretide combined with noninvasive ventilation in treating chronic obstructive pulmonary disease with respiratory failure in the elderly
LIU Sen-guan;LIU Kai;TAN Bai-he;YU Yu-hao
Objective To study the clinical effects of Seretide combined with noninvasive ventilation in treating chronic obstructive pulmonary disease (COPD)with respiratory failure in the elderly.Methods 40 elderly COPD patients with respiratory failure in our hospital from January 2014 to November 2015 were selected and divided into observation group and control group according to random draw,and each group was 20 cases.Patients in the control group were given noninvasive ventilation,and patients in the observation group were given Seretide combined with noninvasive ventilation.The respiratory rate(RR),heart rate(HR)and change level of peak expiratory flow rate(PEF)in two groups were compared.Before and after treatment,the blood gas indexes liked partial pressure of blood oxygen (PaO2),arterial carbon dioxide partial pressure (PaCO2),hydrogen ion concentration index (pH),the change of lung function index liked forced expiratory volume in one second(FEV1),forced vital capacity(FVC)in two groups were compared.Results After treatment,RR and HR in the observation group was obvious lower than that in the control group(P＜0.05).After treatment,the level of PaO2,pH in the observation group obvious increased than that in the control group (P＜0.05);the level of PaCO2in the observation group was decreased obviously than that in the control group (P＜0.05).After treatment,the level of FEV1/FVC in the observation group was increased obviously than that in the control group (P＜0.05).Conclusion Seretide combined with noninvasive ventilation in treating COPD with respiratory failure in the elderly with obvious effects, which can make the patient′s breathing,heart rate gradually return to normal,improve arterial blood gas levels effectively and enhance the lung function.This method is worth to popularize in clinic.
2017 Vol. 24 (4): 26-28 [Abstract] ( 179 ) HTML (44 KB)  PDF  (0 KB)  ( 34 )
29 Clinical effect of ultrasound-guided percutaneous catheter drainage in the treatment of severe acute pancreatitis
HAN Lun;JIN Jing-ping
Objective To investigate the clinical effect of ultrasound-guided percutaneous catheter drainage in the treatment of severe acute pancreatitis.Methods Altogether 120 patients with severe acute pancreatitis(SAP)who were treated in our hospital from June 2015 to June 2016 were selected and divided into control group and observation group according to random number table mothod.Patients in the control group were treated with conventional therapy,while patients in the observation group were treated with ultrasound-guided percutaneous catheter drainage based on conventional therapy.The treatment effect,rehabilitation and change of related laboratory indexes,occurrence of complications of two groups were statistically analyzed and compared.Results The effusion disappearance time,serum C reactive protein(CRP),body temperature and blood amylase recovery time and hospitalization time of the observation group was shorter than that of the control group(P＜0.01);the rate of converting operation of the observation group was 3.33%,significantly lower than that of the control group (18.33%)(P＜0.01).Before treatment,there was no significant difference in the levels of serum amylase,urine amylase and white blood cell between two groups(P＞0.05);after treatment, blood amylase,urine amylase and white blood cells of the observation group was significantly decreased and serum calcium of the observation group was increased significantly in comparison with that of the control group,with statistically significant difference(P＜0.01).The incidence of multiple organ dysfunction syndrome(MODS),acute respiratory distress syndrome (ARDS)and septicemia of the observation group was lower than that of the control group,with statistically significant difference between two groups(P＜0.05).Conclusion Ultrasound-guided percutaneous catheter drainage is featured with minimal invasion,convenience,safety and effective advantages,which not only can reduce the pain of patients,but also reduce the incidence of postoperative complications,promote the rehabilitation of patients and shorten the hospitalization time.
2017 Vol. 24 (4): 29-31 [Abstract] ( 169 ) HTML (38 KB)  PDF  (0 KB)  ( 33 )
32 Application effects of combined with Pulmicort aerosol inhalation in prevention pulmonary infection after hypertensive cerebral hemorrhage operation at perioperative period
LI Jie;LONG Xiao-ao;LI Li-qiu;LIN Heng

Objective To observe the effects of combined with Pulmicort aerosol inhalation in prevention pulmonary infection at perioperative period of hypertensive cerebral hemorrhage,and to further explore the clinical effects of Pulmicort in prevention pulmonary infection.Methods 128 hypertensive cerebral hemorrhage patients who needed to craniotomy for removal of hematoma from January 2013 to June 2016 were selected and divided into the treatment group and the control group.68 patients in the treatment group were used Pulmicort 2 mg combined with Ambroxol Hydrochloride 30 mg aerosol inhalation for 3 times a day from hospitalized to 10 days after operation,60 patients in the control group were used Ambroxol Hydrochloride 30 mg aerosol inhalation for 3 times a day.The level of PaCO2,PaO2,OI and pulmonary infection situation at 1st,5thand 10thdays postoperative in the two groups were compared.Results The level of PaCO2,PaO2and OI in the treatment group at 5thand 10thdays after operation were improved than those in the control group,and the difference was statistical significance(P＜0.05).The incidence rate of postoperative pulmonary infection in the treatment group was 38%,which was lower than that in control group (58%),with significant difference(P＜0.05). Conclusion Pulmicort combined with Ambroxol Hydrochloride aerosol inhalation at perioperative period of hypertensive cerebral hemorrhage can prevent pulmonary infection effectively by enhancing PaO2and decreasing PaCO2,improving oxygenation of organs and tissues.
2017 Vol. 24 (4): 32-34 [Abstract] ( 158 ) HTML (39 KB)  PDF  (0 KB)  ( 37 )
35 Comparison of the application effect of BIPAP at daytime and nighttime in the treatment of chronic obstructive pulmonary diseases
HU Chong-jing;LU Shu-biao;TAN Zhuo-hua;HUANG Xiao-yan
Objective To compare the effect of biphasic intermittent positive airway pressure (BIPAP)at daytime and nighttime in the treatment of chronic obstructive pulmonary diseases(COPD).Methods Altogether 50 cases of acute exacerbation of COPD who were treated in our hospital from July 2014 to May 2016 were randomly selected as the object of this research,and were divided into the daytime group(n=33)and the nighttime group(n=17)according to the time of noninvasive assisted ventilation.The arterial blood gas analysis data (PaCO2,PaO2,PH),peak expiratory flow(PEF)，oxygenation index(OI),respiratory rate(RR),heart rate(HR),blood pressure of the two groups at pre-and post-treatment 2 hours were compared.Results The level of PEF in the two groups after treatment was higher than that before treatment,and the level of PCO2in the two groups after treatment was lower than that before treatment,with significant difference (P＜0.01).The level of PO2in the nighttime group after treatment was higher than that before treatment,and the pH value of the daytime group after treatment was higher than that before treatment,with significant difference (P＜0.01).There was no significant difference between the level of OI,RR,HR and blood pressure of the two groups before and two hours after treatment(P＞0.05).Compared with the nighttime group,the level of PCO2in the daytime group decreased more significantly;compared with the daytime group,the level of PO2in the nighttime group increased significantly,with significant difference(P＜0.01).Conclusion Noninvasive assisted ventilation in different time of the day plays different effect on patients with AECOPD.Clinicians can carry out noninvasive assisted ventilation in different time of the day according to the patient′s conditions.
2017 Vol. 24 (4): 35-38 [Abstract] ( 165 ) HTML (44 KB)  PDF  (0 KB)  ( 36 )
39 Effect of Levocarnitine on myocardial ischemia and cardiac function in elderly patients with heart failure
CHEN Lian-di
Objective To study and analyze the influence of clinical application of Levocarnitine on manifestations of myocardial ischemia and cardiac function in elderly patients with heart failure.Methods From January 2013 to September 2016,92 elderly patients with congestive heart failure were admitted into our hospital and were analyzed.According to the random principle,all patients were evenly divided into control group and research group,with 46 cases in each gorup.Patients in control group were treated with conventional anti-heart failure,while in the research group,on the basis of the control group,Levocarnitine was added.The clinical efficacy,left ventricular ejection fraction before and after treatment and electrocardiogram were compared between the two groups.Results The total effective rate in the research group was 91.30%,higher than that in the control group accounting for 73.91% (P＜0.05).The data of NST and ΣST in the research group were both lower than those in the control group,and the index of LVEF in the research group was higher than that of in control group(P＜0.05).Conclusion In the treatment of elderly patients with heart failure,Levocarnitine can obtain a remarkable effect on effective improvement of myocardial ischemic symptoms and cardiac function.
2017 Vol. 24 (4): 39-41 [Abstract] ( 159 ) HTML (36 KB)  PDF  (0 KB)  ( 38 )
42 The clinical significance of the different types of high blood pressure patients plasma BNP concentration
YANG Jing-yu;LIU Dan
Objective To explore the clinical significance of plasma BNP concentration in different types of hypertension patients.Methods 180 patients with essential hypertension were selected from July 2014 to July 2015，and were respectively divided into pure systolic hypertension group(n=60),pure diastolic hypertension group(n=60)and double hypertension group(sutra hypertension group)(n=60).Then according to cardiac color ultrasound were divided into with, without left atrial enlargement and left ventricular hypertrophy in two subgroups.All of the subjects were monitored in plasma BNP concentration,liver function,renal function,blood lipid indexes,the collected data were analyzed statistically and got the results.Results Plasma concentration of BNP in double hypertension group was higher than that of pure systolic hypertension group and pure diastolic hypertension group(P＜0.01).The concentration of BNP of three groups patients with hypertension and atrial ventricular enlargement was higher than that of normal atrial ventricular(P＜0.01). The concentration of BNP and atrial and ventricular enlargement,renal function,systolic pressure,diastolic positive correlation were existed between pressure (P＜0.01).Conclusion Plasma BNP concentration is the objective evaluation of primary hypertension patients in blood pressure level and a sensitive index of left atrial enlargement and left ventricular enlargement.Monitoring the plasma concentration of BNP may become an important index to judge the severity of hypertension and provide the basis for the diagnosis and treatment of hypertension.
2017 Vol. 24 (4): 42-44 [Abstract] ( 165 ) HTML (42 KB)  PDF  (0 KB)  ( 33 )
45 Role of Tirofiban on left ventricular function and prognosis in patients with acute ST segment elevation myocardial infarction after percutaneous coronary intervention
DAI Jian;WANG Yao-guo
Objective To investigate the effect of Tirofiban on left ventricular function and prognosis in patients with acute ST segment elevation myocardial infarction after percutaneous coronary intervention.Methods 94 patients with ST segment elevation myocardial infarction from June 2014 to June 2016 in our hospital were selected and were divided into two groups according to random number table.The control group was used direct percutaneous coronary intervention,the observation group was used Tirofiban on the basis of control group.The ratio of postoperative TIMI reached 3 grades,average hospital stay,incidence rate of bleeding;difference of left ventricular ejection fraction and quality of life in patients before and after treatment of two groups were compared.Results Ratio of postoperative TIMI reached 3 grades in observation group was obvious higher than that of control group (P＜0.05);average hospital stay of observation group was less and bleeding incidence rate was higher than that of control group(P＜0.01).Before treatment,the left ventricular ejection fraction and quality of life in two groups were similar(P＞0.05);after treatment,the left ventricular ejection fraction and quality of life in observation group were improved more than those of control group(P＜0.05).Conclusion Effect of Tirofiban on left ventricular function and prognosis are definitely in patients with acute ST segment elevation myocardial infarction after percutaneous coronary intervention,which promote blood flow reperfusion,improve the prognosis of patients,shorten the hospitalization time,improve the quality of life of patients,but need to be alert to the occurrence of bleeding after medication.
2017 Vol. 24 (4): 45-47 [Abstract] ( 157 ) HTML (38 KB)  PDF  (0 KB)  ( 41 )
48 Significance of detection of serum Hcy and hs-CRP in patients with H type hypertension and coronary heart disease
DAI Xi-yan;YU Bin
Objective To investigate the significance of serum Hcy and hs-CRP in patients with H type hypertension and coronary heart disease.Methods 88 cases of patients with primary hypertension and coronary heart disease were selected in our hospital from January 2014 to January 2016,48 cases of all the patients were with serum Hcy＜10 μmol/L, which will be set as control group;40 cases of all the patients were with serum Hcy≥10 μmol/L,which were set as observation group.The levels of serum Hcy and hs-CRP in two groups were compared,and the relationship between levels of serum Hcy,hs-CRP and the degree of coronary artery disease was analyzed.Results The serum Hcy of the control group was(8.24±0.96)μmol/L,hs-CRP level was(2.51±1.24)mg/L,the serum Hcy level of the observation group was (22.73±7.23)μmol/L,hs-CRP level was (6.41±1.96)mg/L,the serum Hcy,hs-CRP of the observation group was higher than that of the control group,the difference was statistically significant(P＜0.01).The serum Hcy level of single branch lesions was(16.84+6.01)μmol/L,hs-CRP level was(5.31+1.74)mg/L,the serum Hcy level of double branch lesions was (23.15±7.06)μmol/L,hs-CRP level was(6.25+1.62)mg/L,the serum Hcy level of three branch lesions the serum was (27.95±7.11)μmol/L,hs-CRP level was(8.01±1.81)mg/L,the serum levels of Hcy and hs-CRP in the coronary artery of single,double and three branch lesions showed a gradually increasing trend,the difference was statistically significant (P＜0.01).The serum Hcy levels of stable angina patients in the observation group was(16.31+6.38)μmol/L,hs-CRP level was(5.53+1.61)mg/L,the level of serum Hcy of unstable angina patients was(22.11±7.05)μmol/L,hs-CRP levelwas(6.23±1.71)mg/L,the level of serum Hcy of acute myocardial infarction patients was(25.52±7.53)μmol/L,hs-CRP level was(7.89±1.67)mg/L,the serum levels of Hcy and hs-CRP in patients with stable angina,unstable angina and acute myocardial infarction patients showed a gradually increasing trend,the difference was statistically significant(P＜0.01).The correlation analysis showed that the level of Hcy in patients with H type hypertension and the level of hs-CRP showed significant positive correlation(r=0.411,P=0.043).Conclusion Hcy and hs-CRP were closely related to the degree of coronary artery disease in patients with H type hypertension and coronary heart disease,that detection of serum Hcy,hs-CRP can effectively diagnose the extent of coronary artery disease has clinical significance,it is worth to further promote the application in clinic.
2017 Vol. 24 (4): 48-51 [Abstract] ( 151 ) HTML (46 KB)  PDF  (0 KB)  ( 37 )
52 Correlation between plasma homocysteine,hydrogen sulfide level and migraine in patients with type H hypertension
LIN Wei-dong;WU Xue-feng;LI Ai-guo
Objective To analyze the correlation between plasma homocysteine(Hcy)and hydrogen sulfide(H2S)levels in patients with type H hypertension and the incidence of migraine.Methods 54 patients with type H hypertension (simple hypertension group),39 patients with type H hypertension (hypertension combined with migraine group)and 40 healthy subjects (control group),who accepted treatments in our hospital from January 2013 to October 2016 were selected as the research objects.Then,the plasma levels of Hcy and H2S of three groups of patients were detected and compared by enzyme linked immunosorbent assay and de protein methods,and correlation analysis of plasma Hcy and H2S with migraine by Spearman correlation analysis.Results The difference of plasma Hcy and H2S levels among three groups was statistically significant(P＜0.01).The plasma Hcy level in the hypertension combined with migraine group was significantly higher than that in the other two groups (P＜0.05),H2S level was significantly lower than that in the other two groups(P＜0.05);the plasma Hcy level in the simple hypertension group was significantly higher than that in the control group(P＜0.05),and the level of H2S was significantly lower than that in the control group(P＜0.05).The levels of plasma Hcy and H2S and migraine were analyzed by the linear correlation,and Hcy level was positively associated with migraine (r=0.209,P=0.007),and H2S level was positively associated with migraine (r=0.342,P=0.001).Conclusion The incidence of migraine in patients with type H hypertension is related to the abnormal Hcy and H2S levels,and it can provide reference for the prevention and treatment of disease.
2017 Vol. 24 (4): 52-54 [Abstract] ( 129 ) HTML (40 KB)  PDF  (0 KB)  ( 36 )
55 Role of Thiazolidinediones on the intima-media thickness and ox-LDL in patients with primary hypertension
LIANG Tian-shup;LIU Zhi-hua;LAI Min-yao;YUAN Chun-lei;QIAO Li
Objective To analyze the role Thiazolidinediones on the intima-media thickness and ox-LDL in patients with primary hypertension (PH).Methods 100 patients with PH meeting the standard in our hospital from February 2010 to February 2014 were selected.Patients were divided into two groups:control group (n=50)and treatment group (n=50).All patients were treated with routine antihypertensive and lipid modulating,and treatment group was plused Rosiglitazone 4-8 mg/d,control of blood pressure was in below 140/90 mmHg.The IMT and ox-LDL level of patients were measured in 0,3,6 and 12 months.Results After 3,6 and 12 months treatment,IMT was decreased greatly and ox-LDL level was decreased greatly (P＜0.05).Change of treatment group was obvious compared with control group,and there was a statistical difference (P＜0.05).Conclusion Thiazolidinediones can obviously decrease IMT and ox-LDL level of patients.
2017 Vol. 24 (4): 55-57 [Abstract] ( 155 ) HTML (33 KB)  PDF  (0 KB)  ( 38 )
58 Clinical significance of Lp(a)and hs-CRP detection in ACI
LUO Dong-wei;TANG Xiao-rong
Objective To explore the significance of Lp(a)and hs-CRP detection in acute cerebral infarction(ACI). Methods 68 patients with ACI treated by our hospital from January 2014 to September 2016 were selected as ACI group. 30 healthy people given check-up were selected as control group at the same time in our hospital.The level of Lp(a) and hs-CRP for ACI group and healthy examination group were compared.The level of Lp(a)and hs-CRP for ACI patients with different NIHSS points was compared and the correlation of Lp(a)and hs-CRP in ACI group were analyzed. Results The level of Lp(a)and hs-CRP for ACI group[(334.72±31.56)mg/L and(5.32±2.58)mg/L]was obviously higher than that of healthy examination group[(146.29±21.15)mg/L and(0.87±0.43)mg/L]respectively(P＜0.01);the level of Lp(a)and hs-CRP for ACI patients with different NIHSS points was significantly different(P＜0.01)and with the higher NIHSS points,the serum was gradually increased and the correlation analysis displayed that the detection indicators were positively correlated with each other(r=0.684,P=0.011).Conclusion Serum Lp(a)and hs-CRP is involved with the genesis and progress of ACI,it is considered as the important biological indicators to evaluate the genesis and progress of ACI.The interventions positively conducted can reduce the death rate of ACI and improve the prognosis.
2017 Vol. 24 (4): 58-60 [Abstract] ( 156 ) HTML (36 KB)  PDF  (0 KB)  ( 38 )
61 Clinical study of early surgical treatment ofaneurysmal subarachnoid hemorrhage with Hunt-Hess gradeⅢandⅣ
XIE Fei;CHEN Zhi-yuan;ZENG Jia-liang;YE Yong-qiang
Objective To summarize the clinical experience of early surgical treatment of aneurysmal subarachnoid hemorrhage with Hunt-Hess gradeⅢandⅣ.Methods 60 patients with aneurysmal subarachnoid hemorrhage with Hunt-Hess gradeⅢandⅣadmitted in our hospital from January 2008 to December 2013 were selected.They were all confirmed by 3D-CTA examination including 39 cases of early surgery(＜72 h),and 21 cases of delayed surgery(3～10 d).The clinical curative effect of the patients was observed,and the effect of early surgery and delayed surgery on the therapeutic efficacy were analyzed.Results The situation of early surgical prognosis group was better than that of delayed surgery group (P＜0.05).No recurrence of postoperative bleeding was observed,and 5 cases were died.Conclusion In the treatment for the patients with aneurysmal subarachnoid hemorrhage with Hunt-Hess gradeⅢ andⅣ,the prognosis of the patients receiving early surgery is significantly better than that of delayed operation.
2017 Vol. 24 (4): 61-63 [Abstract] ( 147 ) HTML (39 KB)  PDF  (0 KB)  ( 39 )
64 Effect of Atorvastatin Calcium Tablets treating carotid atherosclerotic plaque in patients with cerebral infarction
WANG Di
Objective To study the effect of Atorvastatin Calcium Tablets treating carotid atherosclerotic plaque in patients with cerebral infarction.Methods Ninety patients with cerebral infarction treated in our hospital from June 2014 to June 2016 were selected and they were divided into two groups by drawing lots,with 45 case in each group.Control group was given basic treatment,while observation group was given Atorvastatin Calcium Tablets for treatment on the basis of the control group.The level of blood lipid and condition of carotid atherosclerotic plaque in patients between two groups were compared.Results There was no significant difference in blood lipid level or condition of carotid atherosclerotic plaque before treatment between groups(P＞0.05).There was a statistical difference of the related indexes of blood lipid before and after treatment in patients between two groups(P＜0.05).The improvement of TC[(4.25±0.51) mmol/L],TG[(1.28±0.40)mmol/L],HDL-C[(2.01±0.60)mmol/L],LDL-C[(1.55±0.57)mmol/L]after treatment in observation group was better than that of control group [(5.73±0.58)mmol/L,(2.34±0.51)mmol/L,(1.08±0.52)mmol/L,(2.46±0.48) mmol/L] (P＜0.05).The related indexes of carotid atherosclerotic plaque after treatment in observation group[TPA (13.52±3.37)mm2,Crouse integration(7.02±2.34)points,IMT(0.96±0.04)mm,and the number of unstable plaque(0.35± 0.72)]was better than that of control group[(20.86±4.54)mm2,(10.67±5.26)points,(1.20±0.16)mm,(1.06±1.14)](P＜0.05). Conclusion Atorvastatin Calcium Tablets treating carotid atherosclerotic plaque in patients with cerebral infarction can effectively reduce the blood lipid level of patients,control the progress of the carotid atherosclerotic plaque,and its clinical effect is exact.
2017 Vol. 24 (4): 64-66 [Abstract] ( 167 ) HTML (39 KB)  PDF  (0 KB)  ( 44 )
67 Effect comparison of standard large bone flap decompression extradural expansion and relieving tension suture operation and temporal muscle adhesion operation treating large area cerebral infarction
XU Xin CHEN;Xiao-ping
Objective To compare the effect of standard large bone flap decompression extradural expansion and relieving tension suture operation and temporal muscle adhesion treating large area cerebral infarction.Methods Clinical data of 78 patients with large area cerebral infarction treated by our hospital from January 2008 to January 2015 were analyzed.Patients were grouped according to different treatment measures.Treatment A group (standard large bone flap decompression extradural expansion and relieving tension suture operation)was 39 cases and treatment B group(standard large bone flap decompression temporal muscle adhesion operation)was 39 cases.Clincial effect,Glasgow outcome score (GOS)after 6 months surgery,neurobehavioral cognitive function (NCSE score)and complications in two groups were observed.Results The clinical effect and GOS,NCSE score after 6 months surgery in patients between two groups had no statistical significance (P＞0.05).The incidence rate of complications in treatment group B was higher than that of treatment group A(P＜0.05).Conclusion Standard large bone flap decompression extradural expansion and relieving tension suture operation and temporal muscle adhesion treating large area cerebral infarction have the better effect,but the incidence rate of complications for temporal muscle adhesion operation is higher.
2017 Vol. 24 (4): 67-69 [Abstract] ( 164 ) HTML (39 KB)  PDF  (0 KB)  ( 39 )
70 Test results analysis of event-related potentials in three common mental disorders
SHAO Chun-li;ZHOU Chao-dang
Objective To analyze the test results of event-related potential in three common mental disorders and their application in the diagnosis of mental diseases.Methods Cases of depression (n=43),schizophrenia(n=53),and chronic alcoholism (n=35)from outpatient clinics and inpatient department from January 2015 to April 2016 were given with event-related potential.The test results were compared with those from 35 healthy participants(control group).The test values of copular(Cz)and frontal(Fz)parts of mismatch negativity(MMN),information input(N1),information synthesis(N2),directional activity(P3a)and cognitive potentials(P3b)were compared.Results The delayed latency of Cz and Fz in MMN,N2,P3a and P3b in patients of depression,schizophrenia and chronic alcoholism was significantly longer than that in the healthy control group(MMN-Cz:t=9.15,8.78,10.9;MMN-Fz:t=10.91,8.51,10.25;N2-Cz:t=4.78, 6.26,4.01;N2-Fz:t=4.26,4.65,3.97;P3a-Cz:t=8.76,8.52,6.39;P3a-Fz:t=9.30,8.77,6.47;P3b-Cz:t=10.46,11.89,8.13; P3b-Fz:t=9.45,10.37,8.36,P=0.000).The delay of latent period for N1-Cz electrode in depression group was shorter than that in schizophrenia group(t=2.77,P＜0.05).The delay of latent period for N2-Cz electrode in chronic alcoholism group was longer than that in schizophrenia group and depression group(t=2.16,2.73,P＜0.05).In the chronic alcoholism group,the delay of latent period for P3a-Fz electrode was longer than that in schizoph-renia group and depression group (t=8.45,8.54,P＜0.01),and the delay of latent period for P3b-Fz electrode was longer than that in depression group(t=2.61,P＜0.05).P300 latency prolonged grade distribution:depression took the majorityof being mild to moderate prolonged,and schizophrenia and chronic alcoholism were in the major of severe prolonging with statistical differences (u=4.50,2.74;P＜0.01,0.05).Years of drinking in chronic alcoholism patients has a high positive correlation with P3a,P3b-Cz,Fz(r=0.727,0.752,0.734,0.578,P＜0.01).Conclusion There is a significant delay in the occurrence of MMN in patients with depression.Compared with schizophrenia,sensitization of sensory information input occurs in depression.There are delay of latent period in information synthesis,directional activity,and cognitive potential to certain degrees in depression,schizophrenia and chronic alcoholism.Among them,conditions in depression is relatively mild,while more severe in chronic alcoholism and schizophrenia.Especially,cognition damage in the frontal lobe of advanced center is most severe.Years of drinking has a remarkable influence on the delay of event-related potentials in patients with chronic alcoholism.
2017 Vol. 24 (4): 70-73 [Abstract] ( 199 ) HTML (49 KB)  PDF  (0 KB)  ( 36 )
74 Influence of early cognitive rehabilitation training on daily life ability of patients with cognitive impairment after stroke
MAI Guang-huai
Objective To explore the application effect of early cognitive rehabilitation training on patients with cognitive impairment after stroke.Methods 98 patients with cognitive impairment after stroke treated in our hospital from March 2013 to August 2015 were selected as the research objects and were divided into observation group and control group according to random number table method,49 cases in each group.Patients in the control group were treated with routine rehabilitation therapy,while the early cognitive rehabilitation training was carried out on the patients in the observation group based on the treatment in the control group.The activities of daily living ability and cognitive function changes of patients in the two groups were observed.Results Before treatment,there were no obvious differences of the activities of daily living and cognitive function between the two groups (P＞0.05),but the conditions were improved after treatment.The score of Barthel index (BI),Fugl-Meyer motor function scale (FM),Montreal cognitive assessment scale (MoCA)and mini mental state scale (MMSE)in the observation group was higher than that in the control group after treatment,with significant difference(P＜0.01).The index differences in the observation group before and after treatment was greater than that in the control group and the differences were statistically significant(P＜0.01).Conclusion Early cognitive rehabilitation training in patients with cognitive impairment after stroke can significantly improve cognitive and motor function and improve the ability of daily life,which is worth promoting.
2017 Vol. 24 (4): 74-76转88 [Abstract] ( 133 ) HTML (42 KB)  PDF  (0 KB)  ( 33 )
77 Clinical effect of hyperbaric oxygen assistant therapy in the treatment of brain edema after meningioma surgery
PENG Mu-jian;SHEN Jian-zhong;ZHOU Liang
Objective To study the clinical effect of hyperbaric oxygen assistant therapy in the treatment of brain edema after meningioma surgery.Methods 40 patients with cerebral edema after meningioma surgery from March 2015 to July 2016 in our hospital were selected and randomly divided into the control group and the observation group,20 cases in each group.The control group was treated with routine therapy,the observation group was treated with hyperbaric oxygen assistant therapy on the basis of the control group.The scores of brain edema quantification index and the total effective rate were compared between the two groups after cerebral edema.Results The total effective rate of the observation group was 85.00%,which was higher than that of the control group (60.00%),with significant difference(P＜0.05).The quantification index of brain edema after treatment in the two groups was lower than that before treatment,with significant difference (P＜0.05).The quantification index of brain edema after treatment in the observation group was (0.21± 0.05)points,which was lower than that in the control group [(1.57±0.53)points],with significant difference (P＜0.05). Conclusion The hyperbaric oxygen assistant therapy can not only promote the recovery of brain tissue function,but also make the cerebral edema rapidly dissipated,which can improve the score of brain edema quantification index,increase the total effective rate,it is worthy of clinical promotion and application.
2017 Vol. 24 (4): 77-79 [Abstract] ( 148 ) HTML (34 KB)  PDF  (0 KB)  ( 32 )
80 Correlation research between Chinese initial syllable fluency test and cognitive function
SONG Ming-qiao;ZHONG Xiao-ming
Objective To explore the correlation between Chines initial syllable fluency test and patients′cognitive level. Methods A total of 120 neuropsychic disturbance patients aged from 28 to 85 years old who were educated for 0 to 19 years at the ratio of 68 to 52 in male to female treated in Dalian Municipal Friendship Hospital from November 2012 to June 2016 were selected.They were performed with Chines initial syllable fluency test and Montreal cognitive assessment scale test.The scores from the two tests were dealt with partial correlation analysis.Results The average score of Chines initial syllable fluency test was(16.3±6.6)points,and the average score of Montreal cognitive assessment scale test was(22.9±4.5)points.With controlling the factors of the age and years of education,the score from the two tests had a remarkable positive correlation(r=0.580,P＜0.01).Conclusion The score of Chines initial syllable fluency test is related with the level of cognitive function,which is expected to be used as a neuropsychological test for measurement of cognitive function in clinic and research.
2017 Vol. 24 (4): 80-82 [Abstract] ( 135 ) HTML (34 KB)  PDF  (0 KB)  ( 39 )
83 Analysis of the efficacy and safety of small amount of Mannitol combined with Bumetanide in the treatment of elderly patients with acute massive cerebral infarction with cerebral edema
ZHANG Yan-ying;SHI Zhen-dong
Objective To evaluate the efficacy and safety of small amount of Mannitol combined with Bumetanide in the treatment of elderly patients with acute massive cerebral infarction with cerebral edema.Methods 106 elderly patients with acute massive cerebral infarction with cerebral edema in our hospital fron January 2010 to December 2015 were selected and divided into the study group(54 cases)and the control group(52 cases)by random number table method. The study group was treated with low dose Mannitol 2 times daily dosing and combined Bumetanide,the control group was treated with low-dose Mannitol daily for 3 times.Antiplatelet aggregation,brain protection,lipid-lowering,stable atherosclerotic plaques and other neurological routine treatment were given in the two groups.The clinical efficacy and adverse reactions of the two groups were observed.Results The total effective rate of the study group and the control group were 87.0%and 88.4%,respectively.There was no significant difference between the two groups (P＞0.05).The total incidence rate of adverse reactions in the study group was 18.5%,which was lower than that of the control group (30.8%),with significant difference(P＜0.05).Conclusion Small amount of Mannitol combined with Bumetanide treatment in elderly patients with acute massive cerebral infarction with cerebral edema is more reasonable,and good safety.
2017 Vol. 24 (4): 83-85 [Abstract] ( 159 ) HTML (40 KB)  PDF  (0 KB)  ( 34 )
86 Ultrasound-guided minimally invasive percutaneous nephrolithotomy and lithotripsy for the treatment of complex renal calculi
YE Ji-rong;YE Qing-yun;DAI Jian-feng
Objective To explore the clinical effect of ultrasound guided minimally invasive percutaneous nephrolithotomy in the treatment of complex renal calculi.Methods 76 patients with complicated renal calculi diagnosed from May 2015 to April 2016 were divided into two groups according to the randomly drawing method.The treatment group (n=38)was underwent ultrasound guided minimally invasive percutaneous nephrolithotomy,the control group (n=38)was treated with open lithotripsy,the incidence of complications,residual rate of stones,operation time and length of stay were compared between the two groups.Results The incidence of complications of treatment group was 7.89%,which was lower than that of control group of 28.95%(P＜0.05).The operation time and hospitalization time of treatment group were shorter than those of control group (P＜0.01).The residual rate of stones in the treatment group was 2.63%,which was lower than that of control group of 26.32%(P＜0.01).Conclusion Ultrasound guided minimally invasive percutaneous nephrolithotomy and lithotripsy for the treatment of complex renal calculus affirmed the clinical efficacy can reduce the incidence of complications and residual stones,shorten the operation time and accelerate the recovery process.
2017 Vol. 24 (4): 86-88 [Abstract] ( 140 ) HTML (35 KB)  PDF  (0 KB)  ( 37 )
89 Observation of the effect of pneumatic lithotripsy under percutaneous nephrolithotomy combined with ultrasound lithotripsy in the treatment of complex renal calculi
GUO Jun-cong
Objective To investigate the therapeutic effect of combined therapy of ultrasound lithotripsy and pneumatic lithotripsy under percutaneous nephrolithotomy(PCNL)for complex renal calculi.Methods A total of 106 patients with complex renal calculi who were given the treatment in our hospital from July 2014 to February 2016 were collected and enrolled in this comparative study.They were evenly divided into two groups according to the random blue and red lottery draw,53 cases in each group.The control group was treated with open surgery,and the observation group was treated with PCNL combined with ultrasonic lithotripsy.The study results were compared and analyzed between the two groups.Results The blood loss during operation,operation time and length of hospital stay in the observation group were lower than those in the control group(P＜0.01).The hospitalization cost in the observation group was higher than that in the control group(P＜0.01);before treatment,there was no significant difference in Scr level between the two groups(P＞0.05).The level of Scr in the observation group was lower than that in the control group at 1 week and 3 months (P＜0.01).There was no significant difference in Scr level between the two groups at 6 months (P＞0.05);the total complication rate of observation group was 9.43%,which was significantly lower than that of 30.19%in the control group (P＜0.05);the stone clearance rate of observation group was 92.45%,which was significantly higher than that of 83.02%in the control group (P＜0.01).Conclusion Combined therapy of PCNL and ultrasound lithotripsy in the treatment of complex renal calculi in clinical situation can achieve ideal therapeutic effect and increase the clearance rate of stones.The value of clinical promotion and application is high.
2017 Vol. 24 (4): 89-91转98 [Abstract] ( 158 ) HTML (42 KB)  PDF  (0 KB)  ( 35 )
92 The clinical research of minimally invasive percutaneous nephroscope with soft ureter mirror therapy on complexed kidney stones
XIE Wei;LUO Jin-tai
Objective To explore the clinical effect of minimally invasive percutaneous nephroscope with soft ureter mirror treating complexed kidney stones.Methods 82 patients with complexed kidney stones from June 2013 to August 2016 in our hospital were selected and randomly divided into two groups.The control group was(n=40)treated with minimally invasive percutaneous nephroscope,while the observation group(n=42)was adopted soft ureter mirror therapy. Blood loss,operative time,hospitalization time of two groups were compared,and one-time calculi clearance rate and complication were compared.Results The operation time,length of staying in hospital respectively were （62.93±9.25）d and（3.31±0.87）d in observation group and were both shorter than （83.84±12.34）d and（5.38±1.26）d in the control group,intraoperative blood loss was （59.85±11.42）ml in observation group,was obvious less than （82.39±15.52）ml in the control group(P＜0.05);The one-time calculi clearance rate of the observation group was 95.24%,was obvious higher than that of 72.50%in the control group,incidence of complications was 19.05%in observation group and was obvious lower than that of 55.00%in the control group,with difference significant(P＜0.05).Conclusion The clinical effect of minimally invasive percutaneous nephroscope with soft ureter mirror treating on complexed kidney stones is obvious, which has small trauma,rapid recovery and high calculi clearance rate,It is worthy of promotion.
2017 Vol. 24 (4): 92-94 [Abstract] ( 118 ) HTML (39 KB)  PDF  (0 KB)  ( 46 )
95 Efficacy of locking plate in the treatment of distal radius fractures
LI Qing
Objective To explore the clinical curative effect of locking plate in the treatment of distal radius fractures. Methods 60 cases of patients with distal radius fracture treated in our hospital from January 2012 to July 2016 were retrospectively analyzed and divided into conservative treatment groups and surgical treatment group according to the different treatment methods,each group of 30 cases.Patients in the conservative treatment group were treated by manual reduction and splint or plaster external fixation,while patients in the surgical treatment group were treated by open reduction and internal fixation,excellent and good rate of Cooney score and the extent of radius height loss were compared between two groups.Results Excellent and good rate of Cooney score in the surgical treatment group 6 months after treatment was 93.3%,which was far more than 70.0%in the conservative treatment group,and the difference was sta tistically significant(P＜0.01),especially in the BC type fracture with articular surface,excellent and good rate in the conservative treatment group was 33.3%,with 81.8%in the surgical treatment group,and the difference was statistically significant(P＜0.05).In the aspect of radius height loss,radius height loss in the surgical treatment group after surgery were better than those in the conservative treatment group,and radius height loss in the surgical treatment group six months after surgery was only(0.10±0.05)cm,while that in the conservative treatment group was as high as(0.65±0.23)cm, which exceeded over acceptable standard(radius height loss＜0.5 cm);the difference of radius height loss the sixth week and the sixth month after treatment between two groups was statistically significant(P＜0.05).Conclusion Locking plate in the treatment of distal radius fractures has good results,especially for patients with intra-articular fractures,which is worthy of clinical use of primary hospital.
2017 Vol. 24 (4): 95-98 [Abstract] ( 127 ) HTML (42 KB)  PDF  (0 KB)  ( 40 )
99 Effect of external fixation combined with exercise therapy in the treatment of distal tibiofibular syndesmosis injury
HE Li-lei;CHEN Xun-wen;ZHAO Li-lian;ZHANG Zhao-ming;ZOU Yun-xuan;FAN Wei-feng;LI Can-yang;TAN Guo-zhao
Objective To observe effect of different external fixation combined with exercise therapy in the treatment of distal tibiofibular syndesmosis injury.Methods 40 patients of distal tibiofibular syndesmosis injury in Foshan Hospital of TCM from June 2013 to June 2015 were collected and divided into observation group (20 cases)and control group (20 cases)by random number table method.Patients were treated with wood splint or U-shaped plaster combined with exercise therapy respectively,Kofoed Scale and AOFAS Ankle Hindfoot Scale were used to evaluate the function of injured ankle joint at the first visit,2 weeks,2 months,6 months after injury,and X-ray was used to evaluate whether distal tibiofibular syndesmosis diastasis.Results There was no statistical difference of Kofoed Scale and AOFAS Ankle Hindfoot Scale(P＞0.05)between two groups，and no patient had distal tibiofibular syndesmosis diastasis,but wood splint had better comfort and benefit early swelling.Conclusion The two kinds of external fixation combined with exercise therapy have good effect in treating distal tibiofibular syndesmosis injury.The external fixation of wood splint is more comfort, more beneficial for decreasing the swelling.It is good to popularize this therapy in clinical practice.
2017 Vol. 24 (4): 99-101转105 [Abstract] ( 136 ) HTML (43 KB)  PDF  (0 KB)  ( 34 )
102 Clinical effects analysis of distal femoral anatomic plate together with long screw in treating distal femoral fracture
YANG Tao;LAN Ying-hua;CHANG Guo-rong;CEN Zhi-cong;GAO Jian-jian
Objective To explore the clinical effects of distal femoral anatomic plate together with long screw in treating distal femoral fracture.Methods A total of 76 cases with distal femoral fracture from July 2013 to June 2015 in Guangzhou municipal Huadu district the 2ndPeople′s Hospital were selected and randomly divided into observation group and control group,38 cases in each groups.The observation group was accepted the treatment of distal femoral anatomic plate with long screw internal fixation,and the control group was treated by locking plate internal fixation.The intraoperative blood loss,bony healing time,operative time,postoperative time of hospitalization,knee joint function scoreandcomplication between two groups were compared.Results All patients were got bony healing after treatment.The intraoperative blood loss of observation group was(286.55±18.74)ml lower than that of control group of(416.45±19.35) ml,with significant difference（t=26.78,P＜0.01）,and bony healing time of observation group was(138.56±18.06)d,was better than that of control group of(185.24±28.26)d（t=18.64,P＜0.01）.The VAS pain scores of observation group at 24 and 48 hours after surgery respectively were(5.68±1.24)scores and(3.56±0.85)scores were lower than those of control group of(6.96±1.13)scores and (4.96±1.12)scores,with differences were significant（P＜0.05）.The operative time and postoperative time of hospitalization between two groups were no significant differences（P＞0.05）.The total postoperative complication of observation group was 5.26%lower than that of control group of 21.05%（χ2=4.15，P＜0.05）,and the excellent rate of knee joint function score of observation group was 92.11%,higher than that of control group of 68.42%（χ2=6.73，P＜0.05）.Conclusion The distal femoral anatomic plate with long screw internal fixation is effective for treating distal femoral fracture,and can be clinically promoted.
2017 Vol. 24 (4): 102-105 [Abstract] ( 127 ) HTML (48 KB)  PDF  (0 KB)  ( 47 )
106 Study ofclinical effect on treating elderly femoral head necrosis in different methods
LU Yu;SHENG Ya-di
Objective To compare the effect of femoral head necrosis treated bytotal hip arthroplasty in a minimally-invasive small incision and traditional artificial total hip replacement.Methods From April 2013 to April 2015,30 elderly patients(35 hips)with avascular necrosis of the femoral head were treated in department of orthopedics in our hospital were selected.they were divided into control group(n=15,18 hips)and observation group(n=15,17 hips)based on different therapeutic methods.In the control group,traditional artificial total hip replacement was used,and in the observation group,total hip arthroplasty in a minimally-invasive small incision was adopted.The surgical time,intraoperative amount of bleeding,score of hip joint(Harris score)and therapeutic effect in two groups were compared.Results In the observation group,the surgical time,the intraoperative amount of bleeding were better than those in the control group(P＜0.01).After therapy,Harris score was significantly improved in two groups(P＜0.01).In the observationgroup,Harris score was greatly higher after therapy than that in the control group(P＜0.01).After one-year follow-up visits,the good rate of observaion group after surgery was 93.33%,higher than that of control group of 60.00%(P＜0.05).Conclusion Both traditional artificial total hip replacement and total hip arthroplasty in a minimally-invasive small incision can improve the function of hip joint in patients with femoral head necrosis,but the latter is more effective whose incidence of postoperative femoral head collapse is lower.
2017 Vol. 24 (4): 106-108 [Abstract] ( 129 ) HTML (38 KB)  PDF  (0 KB)  ( 37 )
109 Effect of prenatal nipple healthcare intervention on the incidence of postpartum mastitis in primigravidas
TANG Xiao-yong
Objective To explore the effect of prenatal nipple healthcare intervention on the incidence of postpartum mastitis in primigravidas.Methods 120 primigravidas with nipple dysplasia and 120 normal primigravidas registered in Guangming New District People′s Hospital and supervised by Dongkeng Community Health Service Center from June 2012 to January 2015 were selected as A group and B group.Two groups were randomly divided into 4 sub-groups (A observation sub-group,A control sub-group,B observation sub-group and B control sub-group 60),with cases in each sub-group.Patients in A observation sub-group and B observation sub-group were received a series of targeted nipple care interventions according to different conditions,including education on prenatal nipple healthcare and the nipple healthcare guidance;while,only general nipple healthcare and cleaning was taken for patients in A control sub-group and B control sub-group.Then,the incidence rate of preterm birth,postpartum 6-month feeding success,mastitis and nipple adverse reactions as well as breast swelling of four subgroups were analyzed.Results The incidence of postpartum cracked nipple,galactostasis and mastitis of A and B observation sub-group was lower than that of A and B control sub-group,the differences were statistically significant(P＜0.05);A observation sub-group had a higher incidence of flat and inverted nipples and higher feeding success rate than A control sub-group;the incidence of postpartum mastitis in A control sub-group was 41.7%,significantly higher than that of B control sub-group (23.3%,P＜0.05);the incidence of postpartum mastitis in A observation sub-group was 10.0%,close to that in B observation sub-group(8.3%,P＞0.05);and the incidence of preterm in four subgroups also had no significant difference (P＞0.05).the incidence ofⅡ-Ⅲdegree of breast swelling in A observation sub-group and B control sub-group was lower than A control sub-group,the difference was statistically significant(P＜0.05).Conclusion Prenatal nipple healthcare intervention can prevent the incidence of postpartum mastitis for primigravidas,especially for pregnant women with abnormal nipples,which is worthy of clinical application.
2017 Vol. 24 (4): 109-112 [Abstract] ( 120 ) HTML (44 KB)  PDF  (0 KB)  ( 36 )
113 Application value of cervical low position water bag in full-term pregnancy
ZHENG He-yuan
Objective To explore the application value of cervical low position water bag(LPWB)in full-term pregnancy. Methods From August 2015 to October 2016,120 pregnant women with full-term pregnancy received treatment in our hospital were selected as objects.According to different labor induction,they were divided into research group and control group.The LPWB was used in the research group for labor induction,while in the control group,oxytocin was applied.The delivery mode,effect of labor induction,total stage of labor,intrapartum bleeding and postpartum hemorrhage, neonatal asphyxia rate,effective rate of cervical ripening and so on between two groups were compared.Results In the research group,after 6 h,12 h,and 24 h therapy,the score of improving cervical ripening by Bishop was obviously higher than that in the control group with a statistical difference(P＜0.01).The total effective rate of facilitating cervical ripening was 81.67%,and the rate in the control group was 60.00%with a statistical difference after comparison(χ2=6.8168, P＜0.05).There were significant difference of labor induction to time in labor in pregnant women with vaginal delivery and total stage of labor in both groups(P＜0.05).With regard to postpartum bleeding,it had no great difference displayed (P＞0.05).In comparison of neonatal Apgar score in the research group and control group,and there was no statistical difference (P＞0.05).Conclusion Cervical LPWB applied in full-term pregnancy can facilitate cervical ripening,speed up the cervical dilatation,shorten the labor time with higher induction rate and safety,and it can effectively decrease the probability of cesarean section,promote natural childbirth,alleviate damage in mother and child,reduce the bleeding during and after delivery,which is worthy of promotion and application in clinic.
2017 Vol. 24 (4): 113-115转122 [Abstract] ( 140 ) HTML (43 KB)  PDF  (0 KB)  ( 36 )
116 Effect of abnormal liver function on pregnancy outcome in patients with hypertensive disorder complicating pregnancy
FENG Yong-ling;YUAN Gui-shu
Objective To investigate the effect of abnormal liver function on pregnant outcome in patients with hypertensive disorder complicating pregnancy(HDCP).Methods 150 patients with HDCP in our hospital who were hospitalized from January 2015 to May 2016 were selected as the experimental group.150 normal pregnant women were selected as the control group.3 ml fasting venous blood of pregnants in two groups were collected for detection of ALT,AST and GGT.The incidence of premature rupture of membranes,premature delivery,postpartum hemorrhage and neonatal distress and neonatal weight were compared between two groups.Results Compared with the control group,the levels of ALT,AST and GGT in the experimental group were higher than those of the control group,the differences were statistically significant(P＜0.05),and the levels of ALT and GGT were significantly higher than those of the control group,were more than 2 times of the control group.The incidence rate of premature rupture of membranes,premature delivery and postpartum hemorrhage in the experimental group was higher than that of the control group respectively;the incidence rate of fetal distress in the experimental group(25.33%)was higher than that of the control group(12.00%),and the average birth weight[(2528.15±379.27)g]was lower than that in the control group[(3295.06±429.81)g],the differences were statistically significant(P＜0.05).Conclusion HDCP and abnormal liver function can increase the incidence of adverse pregnancy outcome and have adverse effect on puerpera and neonatal.
2017 Vol. 24 (4): 116-118 [Abstract] ( 165 ) HTML (39 KB)  PDF  (0 KB)  ( 27 )
119 Clinical effect of immunosuppressor combined with traditional Chinese medicine in the treatment of children with aplastic anemia
ZHANG Juan;LI Jian-chang
Objective To explore the clinical effect of immunosuppressor combined with Bushen Yisui decoction in the treatment of children with aplastic anemia and its influence on peripheral hemogram immune factors.Methods Sixty children with aplastic anemia treated in Affiliated Hospital of Binzhou Medical University from January 2014 to May 2015 were selected and randomly divided into treatment group and control group,wtih 30 cases in each group.In the control group,immunosuppressor therapy was used,while in the treatment group,Bushen Yisui decoction was added.After 6-months treatment,the clinical efficacy,the levels of peripheral hemogram and lymphocyte subsets(CD3+,CD3+CD4+, CD3+CD8+,CD3+CD56+and CD4+/CD8+)were compared between the two groups.Results The total effective rate was 86.67%in the treatment group and 70.00%in the control group,and the difference was statistically significant(P＜0.05). The levels of Hb,WBC,PLT and lymphocyte subsets(CD3+,CD3+CD4+,CD3+CD8+,CD3+CD56+and CD4+/CD8+)were all increased;The levels of CD3+,CD3+CD4+,CD3+CD8+,CD3+CD56+and CD4+/CD8+in both groups were recovered to be normal and had no statistical difference compared with that in the healthy individuals(P＞0.05);the levels of all indexs in the treatment group after treatment were higher than those in the control group,and the differences were statistically significant(P＜0.05).Conclusion The effect of combination of immunosuppressant and traditional Chinese medicine Bushen Yisui decoction in children with aplastic anemia is better than immunosuppressor alone.It can effectively improve the immune response in children and promote the hematopoietic function,and it′s worthy of clinical application and promotion.
2017 Vol. 24 (4): 119-122 [Abstract] ( 163 ) HTML (49 KB)  PDF  (0 KB)  ( 38 )
123 Clinical analysis of delivery mode of post-cesarean section re-pregnancy
LI Meng-na;YANG Hai-lan
Objective To investigate the selection of delivery mode and its influence on the outcome of post-cesarean section re-pregnancy.Methods Puerperas who were hospitalized in the First Affiliated Hospital of Shanxi Medical University from February 2014 to October 2015 were selected:68 pregnant women of re-pregnancy vaginal delivery after cesarean section(group A),68 pregnant women of non-scar uterus vaginal delivery(group B),68 pregnant women of re-pregnancy elective cesarean section after cesarean section in the same period (group C).The delivery outcomes, complications of maternal and children between each group was analyzed and compared.Results The hospitalization time,postpartum hemorrhage volume,total stage of labor,delivery rate,rate of postpartum fever,rate of neonatal asphyxia in the group A and group B had no statistically significant difference(P＞0.05);the time of placental expulsion in the group C was less than that of the group A,the postpartum hemorrhage volume of the group C was more than that of group A,the hospitalization time of group C was longer than that of the group A,the differences were statistically significant (P＜0.05).Conclusion Under the premise of close monitoring of the labor stage and strict control of the indications of vaginal delivery,selection of the vaginal delivery for post-cesarean section re-pregnancy will not increase the incidence of adverse pregnancy outcomes.
2017 Vol. 24 (4): 123-125转131 [Abstract] ( 125 ) HTML (45 KB)  PDF  (0 KB)  ( 42 )
126 Relationship between physical growth deviation and feeding difficulties for outpatient children in department of children healthcare
CHEN Li
Objective To investigate the relationship between physical growth deviation and feeding difficulties for outpatient children in department of children healthcare.Methods The related data of 4017 cases of infants who were treated in our hospital from April 2012 to April 2014 were analyzed by using the self-drafted questionnaire on infant feeding difficulty scale and questionnaire survey for determination of infant physical development.Results Altogether 860 cases had feeding difficulties,the incidence rate was 21.41%;539 cases(62.67%)with mild feeding difficulties;224 cases (26.05%)with moderate feeding difficulties;97 cases(11.28%)with severe feeding difficulties;187 cases(4.66%)with growth retardation;263 cases(6.55%)with low birth weight,225 cases(5.60%)with weight loss.Among 673 cases(78.26%)without growth retardation,492 cases(12.8%)with mild feeding difficulties,157 cases(4.1%)with moderate feeding difficulties,24 cases(0.6%)with severe feeding difficulties,was less than those infants with growth retardation[mild:47 cases(25.1%); moderate:67 cases(35.8%);severe:73 cases(39%)](P＜0.05);there were 453 cases(12.1%)with mild feeding difficulties, 131 cases(3.5%)with moderate feeding difficulties and 13 cases(0.3%)with severe feeding difficulties in those infants without low body weight,was less than those infants with low body weight[mild:86 cases(32.7%);moderate:93 cases (35.4%);severe:84 cases(31.9%)](P＜0.05).Conclusion Taking positive and effective measures in prevention of infant feeding difficulties for outpatient children in Department of Children Healthcare can effectively reduce the incidence of infant growth deviation,strengthen the diet intervention and the knowledge related to infant feeding,and reduce the incidence of physical growth deviation.
2017 Vol. 24 (4): 126-128 [Abstract] ( 112 ) HTML (39 KB)  PDF  (0 KB)  ( 32 )
129 The feasibility and safety of Carboprost Tromethamine in the treatment of postpartum hemorrhage
HE Ying;XIAO Hui-xin
Objective To investigate the feasibility and safety of Carboprost Tromethamine in the treatment of postpartum hemorrhage.Methods Sixty cases of postpartum hemorrhage in our hospital from September 2013 to September 2016 were randomly divided into control group and observation group,30 cases in each group.The observation group was treated with Carboprost Tromethamine and Oxytocin,and the control group was treated with Misoprostol and Oxytocin.The hemorrhage amount after 2 h of postpartum,hemostasis time and clinical efficacy were compared between two groups.Results The hemorrhage amount after 2 h of postpartum[(185.69±3.95)ml vs.(308.26± 21.26)ml],hemostasis time[(18.29±2.16)min vs.(35.26±8.29)min]of the observation group was significantly less than that of the control group the differences were statistically significant(P＜0.01).The total effective rate of observation group was 96.67%,which was significantly higher than that of control group (80.00%),the incidence of adverse reactions in the observation group was lower than that in the control group (3.33%vs.23.33%),the differences were statistically significant(P＜0.05).Conclusion The clinical effect of Carboprost Tromethamine in the treatment of postpartum hemorrhage is significant,and it is safe.
2017 Vol. 24 (4): 129-131 [Abstract] ( 140 ) HTML (35 KB)  PDF  (0 KB)  ( 34 )
132 Application effect analysis of 3L brain towel in cesarean section of placenta previa
LI Wei-lan
Objective To evaluate the application effect of 3L brain towel in cesarean section of placenta previa.Methods The pregnant women used 3L brain towel(the experimental group,n=168)and bent plate in buttock (the control group,n=146)from January 2014 to January 2016 in our hospital were selected,and the influence of intraoperative vaginal bleeding on intraoperative and postoperative nursing was evaluated.Results The amount of blood loss during operation in the experimental group was significantly less than that in the control group,the amount of transfusion and blood transfusion was less than that of the control group,the rate of hysterectomy was lower than that of the control group,and the anesthesia time was shorter than that of the control group(P＜0.05).In experimental group,the incidence rate of pressure ulcer,urinary retention,puerperal infection was lower than those of the control group,the amount of vaginal bleeding after surgery was less than that of the control group(P＜0.05),and the comfort degree of pregnant women was higher than that of control group(P＜0.01).Conclusion 3L brain towel can accurately calculate the intraoperative amount of bleeding and is beneficial to formulate the appropriate therapeutic regimen,which reduces the occurrence of related complications and improve the safety of nursing.
2017 Vol. 24 (4): 132-134 [Abstract] ( 115 ) HTML (37 KB)  PDF  (0 KB)  ( 34 )
135 Study of the relationship between negative emotion and psychological distress in the patients with postpartum depression
ZHANG Xiu-qin;LI Yan-ling;LIU Xue-hui;ZENG Hong-mei;CAO Hu
Objective To explore the relation between negative emotion and psychological distress in the patients with postpartum depression.Methods Five hundred lying-in women from October 2015 to April 2016 deliveried in the First Maternal and Child Health Care Hospital of Rencheng District of Ji′ning (“our hospital”for short)and reviewed in our hospital 42 d postpartum were selected as the study objects.The lying-in women with postpartum depression and without postpartum depression were screened out by EPDS，SDS and DT,and the difference of depression and psychological distress were compared;the relation between depression and psychological pain was analyzed.Results There were 69 patients with postpartum depression in 500 lying-in women,411 lying-in women without postpartum depression,the detection rate of postpartum depression was 13.8%,the scores of DT and SDS in the patients with postpartum depression were higher than those without postpartum depression(P＜0.01);correlation analysis showed that,there was a positive correlation between psychological distress and depression(P＜0.01).Conclusion Psychological distress is connected with depression in the patients with postpartum depression,the improvement of negative emotion will be conducive to relieve psychological distress.
2017 Vol. 24 (4): 135-137 [Abstract] ( 142 ) HTML (40 KB)  PDF  (0 KB)  ( 39 )
138 Observation of the effect of Anscon Silver Ion Antibacterial Gel in the treatment of chronic refractory wounds
ZHU Wei-dong;WANG Fu-sheng
Objective To investigate the clinical effect of Anscon Silver Ion Antibacterial Gel in the treatment of chronic refractory wounds.Methods Altogether 60 patients with chronic refractory wounds who were caused by various etiologies and treated in our hospital from January 2014 to January 2015 were selected as the object of this research and divided into the experiment group and the control group according to the different treatment methods,with 30 cases in each group.Wound debridement treatment was applied frequently with a small amount for each time in the two groups.The experiment group was applied with Anscon Silver Ion Antibacterial Gel and then wrapped up with a piece of gauze bandage,while the control group was wrapped only with Iodophor Vaseline gauze.The pain score,wound healing rate,wound healing time,the positive rate of bacterial culture of residual wound secretion and the incidence rate of adverse reactions after changed dressing were observed in the two groups.Results The pain score of the experimental group was significantly lower than that of the control group,the wound healing rate of the experimental group was significantly higher than that of the control group,the wound healing time of the experimental group was significantly shorter than that of the control group,with significant difference (P＜0.05).The positive rate of bacterial culture of the residual wounds secretion after 7thand 14thdays in the experimental group was significantly lower than that in the control group,with significant difference(P＜0.05).There was no obvious adverse reaction in the two groups.Conclusion Anscon Silver Ion Antibacterial Gel can effectively promote the repair of soft tissue defect and shorten the healing time of chronic refractory wounds.
2017 Vol. 24 (4): 138-140 [Abstract] ( 140 ) HTML (36 KB)  PDF  (0 KB)  ( 41 )
141 Clinical value of Low Molecular Weight Heparin combined with Aspirin in the treatment of pre-thrombotic state of recurrent abortion
XU Wan-yan;LIN Chao-feng;XU Xiao-feng
Objective To investigate clinical effect of Low Molecular Weight Heparin combined with Aspirin in the treatment of pre-thrombotic state of recurrent abortion.Methods 88 patients with pre-thrombotic state of recurrent abortion diagnosed and treated in our hospital from December 2013 to December 2015 were selected and they were divided into two groups according to treatment plan.44 patients treated by Aspirin were selected as control group,while 44 patients treated by Low Molecular Weight Heparin combined with Aspirin were selected as observation group.Clinical related indexes,pregnancy outcome,the incidence of adverse reactions were compared between two groups.Results After treatment,D-two polymer and plasminogen activator inhibitor-1 level were decreased significantly in two groups(P＜0.01).AntithrombinⅢ,β-HCG level,thrombin time increased significantly in two groups(P＜0.01).D-two polymer,plasminogen activator inhibitor-1,abortion rate,incidence rate of adverse reactions in observation group were significantly lower than those in control group(P＜0.01).AntithrombinⅢ,β-HCG,thrombin time,preterm birth rate,term birth rate,live birth rate in observation group were significantly higher than those in control group(P＜0.01).Conclusion Low Molecular Weight Heparin combined with Aspirin have significant effect in treatment for pre-thrombotic state of recurrent abortion,which can improve the clinical indications and pregnancy outcome,which also has high safety and worthy of clinical and promotion and application.
2017 Vol. 24 (4): 141-143转146 [Abstract] ( 136 ) HTML (39 KB)  PDF  (0 KB)  ( 34 )
144 Effect of Butylphthalide combined with Oxiracetam in the treatment of vascular cognitive impairment
YAO Jie-wen;SONG Liu-quan
Objective To investigate the clinical curative effect of Butylphthalide combined with Oxiracetam in the treatment of vascular cognitive impairment(VCI).Methods Altogether 80 cases of patients with VCI who were treated in our hospital from February 2014 to February 2016 were divided into experiment group(n=40)and control group(n=40) according to random number table method.Patients in the control group were treated with Butylphthalide,while patients in the experiment group adopted Oxiracetam treatment on the basis of control group.Activities of daily living(ADL) score and mini-mental state examination(MMSE)score before and after treatment in two groups were observed.Results 4 weeks after treatment,the total effective rate of the experiment group was 90.0%,higher than that of the control group (67.5%),with statistically significant difference(P＜0.05).ADL and MMSE scores before treatment between two groups had no significant difference (P＞0.05);while significantly decreased ADL scores [(30.64±2.67)scores]and increased MMSE scores[(24.32±2.24)scores]were seen in the experiment group in contrast with that in the control group[(39.11±3.63) scores and (20.14±2.15)scores],with statistically significant differences (P＜0.05).Conclusion Application of Butylphthalide combined with Oxiracetam achieves significant effect in the treatment of VCI,which can enhance the patients′ADL,alleviate memory loss and improve the total effective rate.
2017 Vol. 24 (4): 144-146 [Abstract] ( 145 ) HTML (35 KB)  PDF  (0 KB)  ( 35 )
147 Effect of Isosorbide Mononitrate Sustained-release Tablets combined with Qishenyiqi Drop Pills in treatment of chronic heart failure
GUO Hong-kun;ZHANG Hong-jun
Objective To observe the therapeutic effect of Isosorbide Mononitrate Sustained-release Tablets combined with Qishenyiqi Drop Pills in the treatment of chronic heart failure.Methods A total of 100 patients with chronic heart failure were treated in our department of internal medicine from April to November 2016 were selected and randomly divided into treatment group(n=50)and control group(n=50).The participants in the two groups were treated with routine therapy including angiotensin-converting enzyme inhibitors,β-blockers,aldosterone antagonists,diuretics,and if necessary,digoxin.In the treatment group,on the basis of the control group,Isosorbide Mononitrate Sustained-release Tablets and Qishenyiqi Drop Pills were added.One course of treatment was lasted for one month.At least one course of treatment was needed.The improvement of cardiac function before and after therapy was compared.Results The effect in the treatment group was better than that of in control group total effeetive rate:96.00 vs.72.00%,with a statisticant difference (P＜0.05).Conclusion The combination of Isosorbide Mononitrate Sustained-release Tablets and Qishenyiqi Drop Pills intreat ment of chronic heart failure obtains a good effect with a lower incidence of adverse reactions,which is worthy of clinical promotion.
2017 Vol. 24 (4): 147-149 [Abstract] ( 152 ) HTML (36 KB)  PDF  (0 KB)  ( 35 )
150 Clinical analysis of Benazepril combined with Metoprolol in the treatment of heart failure with dilated cardiomyopathy
XU You-fan
Objective To explore the clinical effect of Benazepril combined with Metoprolol in the treatment of heart failure with dilated cardiomyopathy.Methods The clinical data of 60 patients were suffered from heart failure with dilated cardiomyopathy treated in Department of Cardiovascular Medicine,Houjie Hospital of Dongguan from January 2014 to January 2016 were analyzed.According to different therapeutic regimens,they were evenly divided into two groups,control group(Digitalis with Metoprolol,n=30)and observation group(Benazepril with Metoprolol,n=30).The cardiac function and pulmonary function before and after therapy in heart failure patients with dilated cardiomyopathy were observed.The clinical effect of patients suffering from heart failure with dilated cardiomyopathy in the two groups was also observed.Results There was no significant difference in left atrial diameter,left ventricular end diastolic diameter,left ventricular ejection fraction,6 min walking distance,FEV1,FEV1/FVC,or FEV1%before treatment in the two groups(P＞0.05).After therapy,all indexes in the two groups were both better than those before treatment,and these indexes in the observation group after therapy were better than those in the control group(P＜0.05).The total clinical thera peutic effective rate of observation was higher than that of control group,with statisticant difference(P＜0.05).Conclusion Combination of Benazepril and Metoprolol in the treatment of heart failure patients with dilated cardiomyopathy can significantly improve cardiac function,pulmonaryfunction,and improve clinical efficacy,which is worthy of clinical promotion and application.
2017 Vol. 24 (4): 150-152 [Abstract] ( 110 ) HTML (39 KB)  PDF  (0 KB)  ( 37 )
153 Effect observation of Memantine Hydrochloride combined with Nimodipine in the treatment of elderly patients with vascular dementia
CHEN Yi;LI Li-li;LIU Yi
Objective To investigate the effect of Memantine Hydrochloride combined with Nimodipine in the treatment of elderly patients with vascular dementia(VD).Methods 94 elderly patients with VD treated by our hospital from Jan uary 2012 to February 2015 were selected and they were randomly divided into control group(n=47)and observation group(n=47).The control group was given oral Nimodipine.The observation group was given Memantine Hydrochloride for treatment based on the control group.MMSE score,CDR score and ADLS score and adverse events were compared between two groups before treatment and 12 weeks of treatment were observed and compared.Results At 12 weeks of treatment,MMSE and ADLS score of the two groups were significantly increased (P＜0.05),CDR score was significantly decreased(P＜0.05).MMSE and ADLS score of observation group were significantly higher than those of control group(P＜0.05),CDR score was significantly lower than that of control group(P＜0.05)at 12 weeks.There was no significant difference in the incidence of adverse events between the two groups(P＞0.05).Conclusion Memantine Hydrochloride combined with Nimodipine can effectively improve cognitive function and ability of daily life of elderly patients with VD, and it has high security.
2017 Vol. 24 (4): 153-155 [Abstract] ( 142 ) HTML (35 KB)  PDF  (0 KB)  ( 42 )
156 Clinical observation of external application of Chinese herbs in the treatment of thyroid nodules
JIANGXia;LUXue-song;WANGXiu-zhi;SUNYe;CHENBo-yu;LIUWen-qing;LIXiao-jiao;WANGShuang
Objective To observe the clinical effect of external application of Chinese herbs in the treatment of thyroid nodules.Methods 60 patients diagnosed as benign thyroid nodules from July 2015 to June 2016 in the department of endocrinology in our hospital were selected and randomly divided into the control group and the treatment group,30 cases in each group.The control group was given routine follow-up treatment,the treatment group was given external application of Chinese herbs on thyroid gland on the basis of routine follow-up treatment.The course of treatment was lasted for 3 months.The treatment effect and the change of maximum transverse diameter of thyroid nodules before and after treatment were observed.Results The total effective rate in the treatment group was 73.33%,which was higher than that in the control group(10.00%),with significant difference(P＜0.01).The minification of maximum transverse diameter of thyroid nodules in the treatment group after treatment was better than that in the control group,with significant difference (P＜0.01).Conclusion External application of Chinese herbs can obtain great effect on treating benign thyroid nodules.
2017 Vol. 24 (4): 156-158 [Abstract] ( 160 ) HTML (42 KB)  PDF  (0 KB)  ( 41 )
159 Clinical effect observation of Self-Made Bushen Shugan Decoction on treating climacteric syndrome
LIN Yun-yu
Objective To explore the clinical effect of Home-Made Bushen Shugan Decoction on treating climacteric syndrome.Methods From February 2011 to February 2015,253 female cases of climacteric syndrome treated in our department were selected randomly divided into the control group(123 cases)and the observation group(130 cases).The control group was treated with routine western medicine,the observation group was treated with traditional Chinese herbal medicines with the actions of nourishing the kidneys and soothing the liver.The therapeutic effect,symptomaticimprovement,and blood biochemical indicators in the two groups were compared.Results The therapeutic effective rate in the observation group was 94.62%,which was higher than that in the control group (71.54%),with significant difference (P＜0.05).The symptomatic scores of traditional Chinese medicine including tidal fever and sweating,vexation and irrigation,distending pain in the chest and ribs,heart vexation and insomnia,and generalized weakness,etc.after treatment in the observation group was lower than that in the control group,with significant difference(P＜0.05).The level of folliclestimulating hormone,luteinizing hormone,and lipid peroxidation after treatment in the observation group was lower than that in the control group,the levels of E2,β-endorphin,and interleukin-2 after treatment in the observation group was higher than that in the control group,with significant difference(P＜0.05).Conclusion Self-Made Bushen Shugan Decoction on treating climacteric syndrome can obtain a remarkable clinical effect,it is effective in relieving symptoms and regulating endocrine,and has positive clinical significance.
2017 Vol. 24 (4): 159-161 [Abstract] ( 142 ) HTML (41 KB)  PDF  (0 KB)  ( 34 )
162 Study on the biological typing and drug resistance genes of Haemophilus influenzae
ZHOU Shi-juan;LIU Yun-xiang;LIN Hua-jie;YU Jin-sheng;XU Jie-ling
Objective To investigate the positive rate,the biological type and the drug resistance of Haemophilus influenzae.Methods 200 strains of Haemophilus influenzae were separated from outpatient and hospitalized patients of Huidong County People′s Hospital from January 2015 to December 2016.Biological types and beta lactamase were identified with API NH of France bioMerieux identification system.The drug sensitivity test of 12 antibiotics was performed by K-B disk diffusion method.According to the results of drug sensitivity,TEM-1 and ROB-1 gene of the strains ofⅠ,Ⅱ,Ⅲ,andⅣbiotypes were detected by PCR.Results There were 6 biotypes,which were typeⅠ-Ⅴ,andⅧtype.The highest proportion was typeⅢ (38%)and typeⅡ (25%).TypeⅤ,typeⅧwas sensitive to 12 antibiotics.TypeⅣhad the highest antibiotic resistance rate of Ampicillin,Cefuroxime,Ceftazidime,Aztreonam and Azithromycin.35.16% of the strains showed resistance to Ampicillin and other beta lactam antibiotics.34.04%strains produced beta lactam. The positive rate of TEM-1 gene was 54.26%,while the positive rate of ROB-1 gene was 6.38%.Conclusion There were 6 biological type of Haemophilus influenzae in Huidong County People′s Hospital.TypeⅡ and typeⅢ were the dominant biotypes,andⅣtype also shared a certainproportion.TypeⅤ,typeⅧwassensitiveto12antibiotics.Thebiological typewhichwashighestresistancetoantibiotics would be typeⅣ.The production of beta lactamase is mainly mediated by TEM,and just a few strains mediated by ROB-1.To pay attention to the epidemic situation of Hi is of great significance for the selection of antibiotics.
2017 Vol. 24 (4): 162-165 [Abstract] ( 140 ) HTML (44 KB)  PDF  (0 KB)  ( 37 )
166 Investigation on the current situation of safety injection and intervention measures in first-level hospitals in administrative area
TANG Jian-hua;YOU Run-de;ZENG Wen-ling
Objective To get known the status quo of safe injection in the first-level hospitals in the administrative area,and to implement the occupational exposure and prevention and control measures of hospital infection.Methods The nurses on guard in 22 first-level hospitals from March to August 2016 in the administrative area were selected as research objects.The status quo of safe injection and nurse-related knowledge were investigated and intervened.The outcome before and after intervention were compared.Results After intervention,the correct rate of answering safety injection related knowledge,the passing rate of skin test needle using and exchanging for everyone,the passing rate of non-reusing needle on adding new drugs,the passing rate of re-sheathing needle cap without double hands,and the passing rate of separating syringe without bare-hand,were much higher in comparison with those before intervention, which were displayed statistical differences (P＜0.01).Conclusion The safety injection of 22 hospitals in the area is not optimistic.Effective measures including establishing and improving the rules and regulations,configuring the safe injection supplies,normalizing the nurses′operation behavior,strengthening the nurses′knowledge training on safe injection as well as check and supervision can reduce the unsafe injection factors,risk of hospital infection,and improve the current situation.
2017 Vol. 24 (4): 166-169 [Abstract] ( 140 ) HTML (50 KB)  PDF  (0 KB)  ( 35 )
170 Analysis of detection results of Mycoplasma pneumoniae antibody among 29 243 children aged from 0 to 14 years in Chenzhou Area
SHI Wen-yuan;WU Yi;WU Zhi-jian;HE Zhi-gang;LI Sheng-tao;XU Yu-juan;CAO Hong
Objective To investigate and analyse the detection results of Mycoplasma pneumoniae(MP)antibody among children with respiratory tract infection in Chenzhou Area,and to provide an important evidence for the diagnosis and treatment of the disease.Methods MP antibody were detected among 29 243 patients with respiratory symptoms,aged from 0 to 14 years,treated in Chenzhou Children′s Hospital from March 2015 to February 2016 by using passive agglutination method.Meanwhile,the positive rate of MP antibody for different ages and seasons were also analyzed.Results Among the 29 243 cases of children with respiratory tract infection,10 892 cases of MP antibody test results were positive,the positive rate was 37.25%.There was significant difference between the four seasons antibody positive rate,the positive rate of autumn and winter(43.27%,42.15%)was significantly higher than that in spring and summer seasons(34.82%,29.74%), with significant difference(P＜0.01).The positive rate of antibody of female children(44.53%)was higher than that of male children(32.67%),with significant difference(χ2=417.26,P＜0.01).In the 5 age groups,the antibody positive rate of 7-14 years old children was significantly higher than that other age groups,in the group of 0-28 days,the antibody positive rate was 6.10%,which was significantly lower than that the other groups,with significant difference(P＜0.01).The rate of children with MP antibody titer 1∶40 in 0-28 days group and＞28 days-＜1 year were 50.53%and 52.78%,which was higher than that of 4-6 years(36.05%)and 7-17 years old children group(33.52%),with significant difference(P＜0.01).The rate of children with MP antibody titer≥1∶160 in 7-14 years group was 16.60%,which was higher than that of＞28 day-＜1 year(9.44%),1-3 years(12.36%)and 4-6 years (14.49%).Conclusion The incidence rate of MP infection in children in Chenzhou is high,and it is more common in autumn and winter seasons.It is necessary to strengthen the clinical diagnosis and control of MP infection.
2017 Vol. 24 (4): 170-173 [Abstract] ( 148 ) HTML (49 KB)  PDF  (0 KB)  ( 43 )
174 Investigation on AIDS cognition of students in higher vocational colleges and effect study of health education
HU Xiao-ming
Objective To investigate the situation of higher vocational college students′understanding of AIDS,to improve students′cognitive level through health education.Methods From July 2015 to June 2016,a total of 7860 male and female students from higher vocational colleges in a certain area were selected as the study subjects,the cognitive status of AIDS of the students was understood and questionnaire survey was conducted before and after health education,and the results were analyzed and evaluated.Results The awareness rate of AIDS-related knowledge after health education was higher than that before education,the psychological attitude towards AIDS-related events after health education was better than that before education,with significant difference(P＜0.05).After health education,the average score of AIDS-related problems between male and female students was significantly improved,and the difference was statistically significant compared with that before health education(P＜0.01).The scores of AIDS-related attitude of female before and after health education were higher than that of male,with significant difference(P＜0.01).Conclusion It is very effective and necessary for the higher vocational college students to carry out AIDS health education,which can promote AIDS knowledge publicity and lay a practical and good foundation for AIDS prevention and control.
2017 Vol. 24 (4): 174-176转181 [Abstract] ( 136 ) HTML (39 KB)  PDF  (0 KB)  ( 38 )
177 Application effect of comprehensive nursing management in fetuses and neonates with digestive system diseases during perioperative period
HUANG Ru;YAN Sheng-lan;GAO Xiao-yang
Objective To explore the applicationeffect of comprehensive nursing managementin fetuses and neonates with digestive system diseases during perioperative period.Methods From July 2015 to November 2016,a total of 164 neonates with digestive diseases in our hospital were evenly divided into control group and experimental group according to the order of admission,with 82 cases in each group.In the control group,postoperative routine nursing was used,while in the experimental group,they were given the comprehensive nursing management of seamless connection of fetus and neonate with maternal and fetal specialties including pregnancy care,prenatalintervention,neonatal nursing during birth, nursing before and after neonatal surgery,and follow-up visits.The surgical effect,average hospital stay,average hospitalization cost and family satisfaction were compared between the two groups.Results In the experimental group, the cure rate and satisfaction by pediatric patient′s families which were significantly higher than those in the control group (P＜0.05).The average hospital stay and average hospitalization cost in the experimental group were significantly lower than those in the control group,with statistical differences(P＜0.05).Conclusion For fetuses and neonates with digestive system diseases during perioperative period,comprehensive nursing management can effectively decrease neonatal mortality and morbidity,and improve the quality of life of neonates.It can also increase the cure rate and the satisfaction rate of the fetal families.It is great significance to shorten the average hospitalstay,reduce hospitalization cost,and lessen down the burden of family members,which is worthy of application and promotion in the whole city.
2017 Vol. 24 (4): 177-181 [Abstract] ( 134 ) HTML (51 KB)  PDF  (0 KB)  ( 34 )
182 Nursing cooperation of aerosol inhalation combined with high frequency chest wall oscillation sputum elimination machine in the treatment of children with severe pneumonia
GAO Li-hua;WEI Dong;LIU Shuang
Objective To analyze the effect of aerosol inhalation combined with high frequency chest wall oscillation sputum elimination machine in the treatment of children with severe pneumonia,and to explore the nursing cooperation. Methods 108 cases of pediatric with severe pneumonia treated in our hospital from January 2014 to March 2015 were selected as research object and randomly divided into two groups by random number table method,each group of 54 cases.Patients in the control group were given conventional treatment,called back expectoration and inhalation;while patients in the observation group on the basis of routine treatment were given aerosol inhalation combined with high frequency chest wall oscillation sputum elimination machine,and given the corresponding nursing,including basic nursing, inhalation of vibration sputum and anti infection,the clinical efficacy of two groups were compared after treatment.Results Total efficiency rate (94.44%)of the observation group was significantly higher than that of the control group (68.52%),cooling time [(2.09±0.59)d],the improvement time of shortness of breath [(1.52±0.48)d],cough relief time [(2.81±0.87)d],heart failure improved time[(1.69±0.42)d]and pulmonary rales disappeared time[(5.62±1.01)d]of the observation group was significantly less than that the control group [(6.11±1.56)d,(5.42±1.94)d,(7.14±2.86)d,(3.45± 0.99)d and(11.37±3.86)d],with statistically significant difference(P＜0.05).Conclusion For children with severe pneumonia treated by aerosol inhalation combined with high frequency chest wall oscillation sputum elimination machine treatment and appropriate nursing,clinical curative effect is more obvious,the clinical symptom remission time is significantly shorter,to help the restoration of physical and mental health,which is worthy of wide application.
2017 Vol. 24 (4): 182-184 [Abstract] ( 145 ) HTML (41 KB)  PDF  (0 KB)  ( 38 )
185 Application effect of quality control nursing group in surgical treatment of uterine fibroids
ZHANG Min
Objective To explore the application effect of quality control nursing group in surgical treatment of uterine fibroids.Methods 60 patients with uterine fibroids treated in our hospital from February 2015 to March 2016 were divided into routine group and quality control group by randomized grouping table,and were used routine nursing and quality control nursing respectively.The nursing quality and nursing satisfaction between two groups were compared. Results The scores of nursing safety,basic nursing,disinfection and isolation,ward management and medical documents nursing quality in the quality control group was higher than that in the routine group,and the difference was statistical significance (P＜0.05).The nursing satisfaction of patients in the quality control group was 96.67%,obvious higher than 73.33%in the routine group,and the difference was statistical significance (P＜0.05).Conclusion Conducting quality control nursing group in the period of perioperative can improve nursing quality and satisfaction of uterine fibroids patients.
2017 Vol. 24 (4): 185-187 [Abstract] ( 138 ) HTML (36 KB)  PDF  (0 KB)  ( 38 )
188 Effect analysis of intensive health education on nursing quality for maintenance hemodialysis patients
XIE Yu-qiu
Objective To explore the effect of intensive health education on the nursing quality for maintenance hemodialysis patients(MHP).Methods Altogether 140 MHP who were treated in Department of Nephrology in our hospital from June 2015 to June 2016 were randomly divided into two groups according to the different methods of nursing,each group with 70 cases.Control group received routine nursing,while observation group were applied with intensive health education.The symptom control rate,incidence of adverse reactions,mastery of health knowledge and quality of life of two groups were compared.Results The blood pressure control rate,dialysis adequacy rate and blood phosphorus rate of the observation group was significantly better than that of the control group,with statistically significant difference(P＜0.05). The indwelling catheter infection rate,fistula blockage rate and non-dialysis time emergency treatment rate and the incidence of hyperkalemia critical value of the observation group was significantly lower than that of the control group, with statistically significant difference(P＜0.05).The disease knowledge score,dietary knowledge score,drug knowledge score and self-care knowledge score of the observation group was significantly better than that of the control group,with statistically significant difference(P＜0.05);SF-36(the MOS Item Short From Health Survey)scores of the observation group (including the physiological function,physiological role,body pain,general health,vitality,social functions,emotional function and mental health)was significantly better than that of the control group,with statistically significant difference(P＜0.05).Conclusion Intensive health education plays a significant role in increasing the nursing quality for MHP,which can improve the symptom control rate and patients′quality of life,reduce the incidence of complications and enhance the mastery of health knowledge,improve the quality of life.
2017 Vol. 24 (4): 188-190转193 [Abstract] ( 157 ) HTML (44 KB)  PDF  (0 KB)  ( 39 )
191 Application of nursing intervention in preventing postpartum hemorrhage in puerperae with vaginal delivery
HUANG Li-mei;DENG Jie
Objective To explore application of nursing intervention in the prevention of postpartum hemorrhage in puerperae with vaginal delivery.Methods From June 2015 to June 2016,110 puerperaes with vaginal delivery in our Department of Obstetrics were selected and divided into conventional group and prevention group according to the different methods of nursing,each group was 55 cases.In the conventional group,regular nursing intervention was applied, while in the prevention group,prevention nursing intervention was adopted.The impact of postpartum hemorrhage by different nursing mode was compared and analyzed.Results In the prevention group,the amount of bleeding 2 h and 24 h after delivery were less than those in the control group(P＜0.01).The incidence of postpartum hemorrhage in the prevention group was lower than that in the conventional group (P＜0.05).The total incidence of postpartum adverse reactions was not significantly different between two groups (P＞0.05).Conclusion Preventive nursing intervention can effectively reduce the postpartum hemorrhage in puerperae with vaginal delivery,and then reduce its risk and promote the prognosis,which is worthy of promotion.
2017 Vol. 24 (4): 191-193 [Abstract] ( 120 ) HTML (38 KB)  PDF  (0 KB)  ( 34 )
194 Application effect comparison of continuous comprehensive nursing and conventional nursing in elderly patients with hip fracture
CHEN Shi-xiao
Objective To compare the effect of continuous comprehensive nursing and routine nursing in elderly patients with hip fracture.Methods Altogether 58 cases of elderly patients with hip fracture treated in our hospital from March 2015 to June 2016 were randomly divided into observation group and control group.The patients in control group (n= 29)were given with routine nursing nursing,while observation group (n=29)was given with comprehensive nursing.The Harris hip score,Barthel index,geriatric depression scale (GDS)score and other indicators after discharge,1 month after discharge and 3 months after discharge between two groups were evaluated and compared.Results The Harris hip score of observation group 1 month and 3 months after discharge [(61.1±8.3)and (78.4±9.8)points]was significantly higher than those of control group [(53.2±7.5)and (64.4±8.6)points](P＜0.05).Barthel index of observation group 1 month and 3 months after discharge[(57.2±8.5)and(81.2±8.2)points]was higher than those of control group[(40.8± 10.2)and(70.3±8.7)points](P＜0.05).GDS score of observation group[(8.5±3.2)points]3 months after discharge was significantly lower than that of control group[(11.9±3.5)points](P＜0.05).Conclusion The effect of continuous comprehensive nursing in improving the recovery of hip function in elderly patients is better than that of routine nursing,which is helpful to improve the quality of daily life.
2017 Vol. 24 (4): 194-196 [Abstract] ( 108 ) HTML (39 KB)  PDF  (0 KB)  ( 36 )
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