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2020 Vol. 27, No. 36
Published: 2020-12-28
 
 
4 Effect of ethanol extract of Fructus Gardeniae Leaves on the melanin formation and tyrosinase activity of B16 melanoma cells
HUANG Shuo； LIU Feng
Objective To investigate the effect of 70% ethanol extract of Fructus Gardeniae Leaves on the melanin formation and tyrosinase activity of B16 melanoma cells.Methods The B16 melanoma cells were divided into blank group,model group,positive control group and 70% ethanol extract of Fructus Gardeniae Leaves group (low concentration group [100 mg/L],medium concentration group [200 mg/L] and high concentration group [400 mg/L]).The B16 melanoma cells were addressed with 70% ethanol extract of Fructus Gardeniae Leaves and induced by α-melanocytestimulating hormone (α-MSH) for 72 h.The proliferation activity of the cells was detected by MTS,and the content of melanin and the activity of tyrosinase in the B16 melanoma cells were determined by enzyme linked immunosorbent assay..Results The 70% ethanol extract of Fructus Gardeniae Leaves with concentration of 100-400 mg/L had no effect on the proliferation of B16 melanoma cells.The content of melanin and tyrosinase activity in B16 melanoma cells in model group were significantly higher than those in blank group,with highly statistically significant differences (P<0.001).The content of melanin and tyrosinase activity in B16 melanoma cells in the 70% ethanol extract of Fructus Gardeniae Leaves were lower than those in the model group,and the differences were statistically significant (P<0.05).The content of melanin and tyrosinase activity in B16 melanoma cells in the positive control group were significantly lower than those in the model group,and the differences were highly statistically significant (P<0.001).Conclusion The 70% ethanol extract of Fructus Gardeniae Leaves can effectively inhibit the generation of α-MSH-induced melanin in B16 melanoma cells,and the mechanism may be related to the inhibition of tyrosinase activity
2020 Vol. 27 (36): 4-7转12 [Abstract] ( 36 ) HTML (1 KB)  PDF  (0 KB)  ( 12 )
8 Application of neuroelectrophysiological monitoring in endovascular treatment of intracranial aneurysms
ZHANG Bai-lin； ZHANG Zhen-yu；ZOU Min-gang； ZENG Hai-lan ；HUANG Jin-qing ；ZHOU Xiao-ping； YANG Rui-jin； JIANG Qiu-hua
Objective To explore the application of neuroelectrophysiological monitoring in endovascular treatment of intracranial aneurysms.Methods A total of 112 patients with intracranial aneurysms treated in Ganzhou Hospital Affiliated to Nanchang University from October 2015 to June 2018 were selected as the research objects.They were divided into two groups according to whether neuroelectrophysiological monitoring was used during the operation.There were 42 patients in the monitoring group and 70 cases in the non-monitoring group.The somatosensory evoked potential (SEP),motorevoked potential (MEP),brainstem auditory evoked potential (BAEP) and scalp electroencephalography (EEG)were conducted depending on the location of the aneurysm and its associated vascular territory,the treatment outcome was evaluated using modified Rankin scale (mRS) score at follow-up.The postprocedural neurological deficits within 24 hours after operation and the prognosis at 6 months after operation in two groups were compared and analyzed..Results Intraoperative changes in SEP tracings alone were found in 8 patients in the monitoring group,SEP and EEG changes were noted in 2 patients.SEP,MEP and EEG changes were noted to be simultaneous in 1 patient.The prevalence of postprocedural neurological deficits within 24 hours after operation in the monitoring group was lower than that in the non-monitoring group,there was statistically signifcant difference (P<0.05).No statistical difference was found in the prognosis at 6 months after operation between the two groups (P>0.05).Conclusion In the endovascular treatment of intracranial aneurysms,multimodal neuroelectrophysiological monitoring can timely reflect brain tissue ischemia,improve the safety of surgery,and reduce the occurrence of postprocedural neurological deficits after operation.
2020 Vol. 27 (36): 8-12 [Abstract] ( 29 ) HTML (1 KB)  PDF  (0 KB)  ( 9 )
13 Study on the confirmation of the filtration process of Recombinant Human Granulocyte Macrophage Colony Stimulating Factor
WEI Rong-hua； KONG Wen-wen ；ZHOU Mao-de； WANG Wei-wei
Objective To investigate the interaction between the filter (filter membrane) and Recombinant Human Granulocyte Macrophage Colony Stimulating Factor (rhGM-CSF) liquid.Methods The adsorptivity,extractablility and compatibility of the filter were tested to confirm that it met the Guangzhou Baiyunshan Baidi Biopharmaceutical Co.,Ltd.quality requirements..Results The active drug ingredient rhGM-CSF had no obvious adsorption before and after filtration.Each Millipak 20 filter could extract a total of 0.5 mg of non-volatile matter,and 0.3 mg organic carbon in total.The extracts were identified as polyacrylate by Fourier transform infrared spectroscopy (FTIR) and reversed phase-high performance liquid chromatography (RP-HPLC) analysis without biological toxicity.Both the membrane and filter showed no compatibility.Conclusion The filters and membranes used meet the drug quality requirements and can provide data support for further evaluation of the filtration process.
2020 Vol. 27 (36): 13-16 [Abstract] ( 33 ) HTML (1 KB)  PDF  (0 KB)  ( 12 )
17 Effect comparison between ultrasonic body surface localization of breast tumor combined with lesion staining and wire localization for the assisted resection of non-palpable breast lesion
YANG Xiao-dong； ZHENG Yue-xin； ZHANG Xi-liang
Objective To compare the effect between ultrasonic body surface localization of breast tumor combined with lesion staining and wire localization for the assisted resection of non-palpable breast lesion (NPBL),so as to explore the application value of ultrasonic body surface localization of breast tumor combined with staining technology.Methods The clinical data of 102 patients with NPBL undergoing surgical treatment in the Sixth Medical Center of PLA General Hospital from July 2016 to July 2019 were retrospectively analyzed.Of the patients,51 cases underwent ultrasonic body surface localization combined with lesion staining (observation group) and the other 51 cases underwent ultrasound-guided wire-localized surgical resection (control group).The relevant surgical parameters such as length of incision,intraoperative blood loss,operation time,and incidence of postoperative complications,total satisfaction rate and tumor recurrence between the two groups were compared..Results The incision length and operation time of the observation group were shorter than those of the control group,and the intraoperative blood loss was less than that of the control group,the differences were statistically significant (P<0.05).The total satisfaction rate of the observation group was higher than that of the control group,and the difference was statistically significant (P<0.05).There was no significant difference in the total incidence of postoperative complications between the two groups (P>0.05).The success rate of surgery in both groups reached 100%.No residual tumor or recurrence occurred in the two groups during followed up for 1 to 6 months.Conclusion Application of ultrasonic body surface localization combined with lesion staining for resection of NPBL has accurate positioning,small incision,short operation time,less intraoperative blood loss,high satisfaction,and favorable promotion.
2020 Vol. 27 (36): 17-20转28 [Abstract] ( 28 ) HTML (1 KB)  PDF  (0 KB)  ( 10 )
21 Experience of using Chinese medicine to prevent Novel Coronavirus pneumonia in Changde First Hospital of Traditional Chinese Medicine
LI Fei-fei；TAN Hong-zhen； ZHONG Fa-ping
ased on the guidance of the idea of ″preventive treatment of disease″,after the outbreak of the epidemic,Changde First Hospital of Traditional Chinese Medicine deeply studied the relevant experience of ″treating epidemic disease″ of traditional Chinese medicine,combined modern media technology with traditional Chinese medicine therapy,and deeply explored traditional Chinese medicine therapy,including oral administration of preventive decoction,external fumigation,wearing sachet,food therapy,foot bath,epidemic prevention moxibustion,etc.Traditional Chinese medicine methods,such as emotional therapy,regulate qi and blood of human body in an all-round way,improve human immunity,make ″positive qi store inside,evil can not invade″,effectively block the further spread of the epidemic in the hospital,and achieve the goal of no one infected in the hospital.Active use of traditional Chinese medicine not only has a favorable impact on social stability and economic development,but also deepens the public′s understanding of traditional Chinese medicine,which is conducive to the further development of traditional Chinese medicine,ushering in another "spring" of the development of traditional Chinese medicine,which is worthy of further clinical research and wide application.
2020 Vol. 27 (36): 21-24 [Abstract] ( 28 ) HTML (1 KB)  PDF  (0 KB)  ( 12 )
25 Research progress on the relationship between chorioamnionitis and neonatal pneumonia
JIAO Hong-mei； LI Yu-fen；LI Ping； ZHANG Miao； LU Dan-dan
Chorioamnionitis is an inflammation caused by pathogen infecting the chorionic membrane and amniotic membrane of the mother placenta.It is also the most common diagnosis in the pathological report of placenta.It can cause serious adverse reactions to pregnant women and newborns,especially closely related to premature rupture of membranes and neonatal pneumonia.However,the incidence of neonatal pneumonia is insidious,easy to miss diagnosis and misdiagnosis,seriously endangering the lives of children.In this paper,the clinical relationship between chorioamnionitis and neonatal pneumonia was discussed to provide clinical guidance for pregnant women and the newborn,provide important reference value for early prevention,and reduce morbidity and mortality of children.
2020 Vol. 27 (36): 25-28 [Abstract] ( 31 ) HTML (1 KB)  PDF  (0 KB)  ( 12 )
29 Study on applicability of microbial limit test method for Yangyin Qingfei Pills
WANG Jing ；ZHANG Xiu-hua； REN Zhong-li； SHENG Chun-lei ；YAN Shi-sheng
Objective To unified establish the applicability test of microbial limit test method for Yangyin Qingfei Pills of four companies.Methods According to the Chinese Pharmacopoeia 2015 edition of four general principles of the 1105,1106 for Yangyin Qingfei Pills applicability test was carried out by microorganism counting method and control bacteria inspection method..Results Four companies keep Yangyin Qingfei Pills total number of aerobe mold and yeast count method applicability test total recovery ratio was between 0.5-2.0,the control bacteria test could detect positive bacteria.Conclusion The total count method and control bacteria examination method of aerobic bacteria,mold and yeast in Yangyin Qingfei Pills of four companies can be checked according to the conventional method,thus unifying the applicability test of microbial limit test method for Yangyin Qingfei Pills of four companies.
2020 Vol. 27 (36): 29-32 [Abstract] ( 26 ) HTML (1 KB)  PDF  (0 KB)  ( 15 )
33 Determination of cinnamaldehyde and trans-anethole in Sanxiang Powder by GC method
CHEN Xiao-yong；GE Yu-song；ZHI Rong-rong
Objective To establish the method for the determination of cinnamaldehyde and trans-anethole in Sanxiang Powder.Methods The volatile components in Sanxiang Powder were extracted by steam distillation and the contents of cinnamaldehyde and trans-anethole were determined by gas chromatography (GC).The chromatographic column was Agilent DB-WAX (30 m×0.320 mm,0.25 μm).The programmed-temperature was used.The inlet temperature was 250℃,the FID detector temperature was 300℃,the flow rate was 30 mL/min,the injection volume was 1 μL,and the split ratio was 10 ∶1..Results The cinnamaldehyde showed a good linear relationship in the concentration range of 0.002 13-0.042 56 mg/mL,with the average recovery of 99.2% and RSD of 1.50%.The trans-anethole showed a good linear relationship in the concentration range of 0.0734-0.9180 mg/mL,with the average recovery of 99.7% and RSD of 1.80%.Conclusions The method established in this study has the characteristics of good repeatability,convenience,feasibility and simplicity,and can be used for the determination of cinnamaldehyde and trans-anisole in Sanxiang Powder.
2020 Vol. 27 (36): 33-36 [Abstract] ( 30 ) HTML (1 KB)  PDF  (0 KB)  ( 14 )
37 Effect of hyperbaric oxygen combined with Memantine Hydrochloride in the treatment of dementia patients with Parkinson′s disease
PENG Wei；SONG Hai； WANG Yu-mei；ZHOU Hua-jun
Objective To analyze the effect of hyperbaric oxygen combined with Memantine Hydrochloride in the treatment of dementia patients with Parkinson′s disease (PD).Methods A total of 68 patients with PD and dementia diagnosed in Wuwei People′s Hospital,Gansu Province from January to December 2019 were selected.They were divided into the control and the observation group according to random number table method,34 cases in each group.The patients in the control group were treated with Memantine alone,and the patients in the observation group were treated with hyperbaric oxygen combined with Memantine Hydrochloride.The therapeutic effects of the two groups and the adverse reactions during treatment were compared..Results After treatment,the scores of the simple mental state scale(MMSE) and the Montreal cognitive assessment scale (MOCA) in the observation group and the control group were improved,but the MMSE,MOCA scores in the observation group were higher than those in the control group,the differences were statistically significant (P<0.05).There were 1 case of nausea and 2 cases of dizziness in the observation group,which were significantly improved after the intervention of symptomatic treatment measures.There was no statistically significant difference in the total incidence of adverse reactions between the control group and the observation group (P>0.05).Conclusion Memantine Hydrochloride is safe and feasible in the treatment of senile dementia with PD,which can effectively improve cognitive function and imprave daily self-care ability.
2020 Vol. 27 (36): 37-39转55 [Abstract] ( 27 ) HTML (1 KB)  PDF  (0 KB)  ( 11 )
40 Application effect of accurate cardiac gastric varicose devascularization under endoscope
HU Min ；CAI Chang-chun； ZHAO Han； YANG Rong ；XIE Min-hua ；SHI Yan-qing
Objective To investigate the application effect of accurate cardiac gastric varicose devascularization under endoscope (ESVD).Methods From May 2018 to January 2019,100 patients with ruptured esophageal and gastric varicose bleeding from liver cirrhosis treated in Affiliated Hospital of Jiujiang University were selected as subjects.They were divided into observation group (n=50) and control group (n=50) according to random number table method.The observation group was treated with ESVD,the control group was treated with the traditional way.The effectiveness of treatment,the incidence of rebleeding and the mortality of follow-up in the two groups were compared..Results The success rate of initial hemostasis and the effective rate of one-time elimination of varicose veins in the observation group were higher than those in the control group,and the operation time was shorter than that in the control group,and the differences were statistically significant (P<0.05).The hospital stay in the observation group was shorter than that in the control group,and the incidence of rebleeding and mortality were lower than those in the control group,and the differences were statistically significant (P<0.05).Conclusion ESVD can improve the therapeutic effect and prognosis of patients with esophageal and gastric varicose bleeding due to portal hypertension in liver cirrhosis.It can be used as a safe and effective endoscopic treatment.
2020 Vol. 27 (36): 40-42 [Abstract] ( 33 ) HTML (1 KB)  PDF  (0 KB)  ( 13 )
43 Application effect of clinical first aid measures in postpartum hemorrhage with coagulation disorders
ZOU Fang-qiang；LU Xiang-lian
Objective To analyze the effect of clinical first aid measures on the curative effect,coagulation function and the incidence of complications taken for patients with postpartum hemorrhage and coagulation disorders.Methods A total of 100 patients with postpartum hemorrhage and coagulation disorders who were admitted to Ganzhou Municipal Hospital from February 2016 to December 2019 were divided into control group and observation group according to random number table method,50 cases in each group.The control group was treated with pelvic arterial embolization,and the observation group was given first aid measures on the basis of the control group.The recovery of condition,coagulation function and postoperative complications were compared between two groups..Results The total effective rate of recovery in the observation group (94.00%) was higher than that in the control group (74.00%) the difference was statistically significant (P<0.05).There were no significant differences in prothrombin time (PT),activated partial thromboplastin time (APTT),fibrinogen (FIB) and thrombin time (TT) between the two groups before operation (P>0.05).The PT in the two groups after operation was longer than that before operation,while the APTT and TT after operation were shorter than those before operation,and the levels of FIB after operation were lower than those before operation,the difference was statistically significant (P<0.05).After the operation,the PT in the observation group was longer than that in the control group,the APTT and TT were shorter than those in the control group,and the level of FIB was lower than that in the control group,the differences were statistically significant (P<0.05).The total incidence of complications in the observation group (6.00% [3/50]) was lower than that in the control group (22.00% [11/50]),the difference was statistically significant (P<0.05).Conclusion Clinical first aid measures taken for patients with postpartum hemorrhage and coagulation disorders can not only improve the coagulation function of patients,but also reduce the incidence of complications and promote the recovery of the disease.
2020 Vol. 27 (36): 43-45 [Abstract] ( 27 ) HTML (1 KB)  PDF  (0 KB)  ( 13 )
46 Application study of ultrasound-guided deep cervical plexus+bilateral superficial cervical plexus block in thyroid surgery
CHENG Xiao-ling； HUANG Chong-feng； ZHONG Rong-ming； ZHANG Qing-qing； JIAO Feng
Objective To explore the application effect of ultrasound-guided deep cervical plexus+bilateral superficial cervical plexus block anesthesia in thyroid surgery.Methods A total of 60 cases of thyroid surgery admitted to Ganzhou Municipal Hospital,Jiangxi Province from January 2019 to June 2020 were selected as research subjects.The computer randomized grouping method was used to divide them into three groups,namely group A,group B,and group C,20 cases in each group.Group A underwent ultrasound-guided deep cervical plexus+bilateral superficial cervical plexus block anesthesia,group B underwent simple cervical plexus block,and group C underwent general anesthesia intubation.The mean arterial pressure and heart rate changes and complications of the three groups were compared.Incidence rate,anesthesia comfort score were compared..Results The mean arterial pressure and heart rate in different time periods in group A were better than those in group B and group C (P<0.05); the total incidence of complications in group A was lower than that in group B and group C (P<0.05); comfort score of group A was higher than that of group B and group C,the differences were statistically significant (P<0.05).Conclusion In thyroid surgery,ultrasound-guided deep cervical plexus+bilateral superficial cervical plexus block anesthesia has a significant anesthetic effect and is worthy of clinical reference.
2020 Vol. 27 (36): 46-48 [Abstract] ( 27 ) HTML (1 KB)  PDF  (0 KB)  ( 16 )
49 Effect of Tenofovir Dipivoxil combined with Lamivudine in the treatment of AIDS combined with hepatitis B virus infection
WU Jing ；AO Jian； LIU Ping-qing； HU Dian-gui
Objective To explore the clinical effect of Tenofovir Dipivoxil combined with Lamivudine in the treatment of AIDS combined with hepatitis B virus infection.Methods The 78 patients of AIDS with hepatitis B virus infection admitted to the 5th People′s Hospital of Ganzhou from September 2017 to January 2019 were selected as the research subjects.They were divided into a control group and an observation group according to the method of drawing lots,39 cases in each group.The control group was treated with Lamivudine,the observation group was treated with Tenofovir Dipivoxil combined with Lamivudine.The positive rate and content of hepatitis B virus (HBV) DNA,RNA conversion rate of human immunodeficiency virus (HIV),recurrence rate of alanine aminotransferase (ALT) and the total incidence of adverse reactions rate were compared between the two groups..Results After 6 months and 1 year of treatment,the positive rate and content of HBV DNA in the observation group were lower than those in the control group,the differences were statistically significant (P<0.05).After 6 months and 1 year of treatment,the HIV RNA negative rate and ALT normalization rate in the observation group were higher than those in the control group,the differences were statistically significant (P<0.05).There was no significant difference in total incidence of adverse reactions between the two groups (P>0.05).Conclusion Tenofovir Dipivoxil combined with Lamivudine in the treatment of AIDS complicated with hepatitis B virus infection has the advantages of high efficacy and safety,which is worthy of promotion.
2020 Vol. 27 (36): 49-51转59 [Abstract] ( 32 ) HTML (1 KB)  PDF  (0 KB)  ( 12 )
52 Effect analvsis of Allicin in the treatment of long-term bedridden senile pneumonia
JIN Wu-juan
Objective To evaluate the clinical effect of Allicin in the treatment of long-term bedridden senile pneumonia.Methods A prospective randomized control study was conducted.Totally 105 long-term bedridden senile pneumonia patients treated in Hefei Binhu Hospital from October 2018 to February 2020 were selected,and were divided into the control groups (n=60) and the treatment group (n=45) with simple randomization.The control group was treated with pneumonic standard treatment,and the treatment group was given extra Allicin for 14 d on the basis of the therapy of the control group.Distribution of pathogenic bacteria,inflammation indicators,therapeutic efficacy and durations of antibiotics were compared and analyzed between the two groups.Allicin adverse reactions and its incidence rate were recorded throughout the course..Results ①The most common pathogens were Pseudomonas aeruginosa (36.2%),Klebsiella pneumonia (23.8%),Escherichia coli (7.6%),Acinetobacter baumannii (4.8%) and Staphylococcus aureus (4.8%)in long-term bedridden senile pneumonic patients.②The levels of white blood cell (WBC) and C-reactive protein(CRP) of the treatment group were lower than those in the control group after therapy,the differences were statistically significant (P<0.01).③The rate of therapeutic effect of 97.8% in the treatment group was higher than 76.7% of the control group,the difference was statistically significant (P<0.05).④The antibiotics using time was shorter than that in the control group,the difference was statistically significant (P<0.01).⑤The incidence rate of adverse reactions in the treatment group was 4.44%,one was diarrhea,and the other was skin rash.Conclusion Additional Allicin treatment in long-term bedridden senile pneumonic patients can significantly shorten the use of antibiotics and improve the curative effection on the basis of treatment with antibiotic,and it could be safe with low incidence of adverse reactions when used in clinic.
2020 Vol. 27 (36): 52-55 [Abstract] ( 28 ) HTML (1 KB)  PDF  (0 KB)  ( 12 )
56

 Application of RDW combined with cTnI in the diagnosis of myocardial injury in patients with severe pneumonia

 Application of RDW combined with cTnI in the diagnosis of myocardial injury in patients with severe pneumonia[J]. 中国当代医药, 2020,27(36): 56-59')" href="#"> Zhongyahua

Objective To explore the changes of RDW and cTnI in the serum of patients with severe pneumonia and their diagnostic value for myocardial injury. Methods  Selected 80 patients with severe pneumonia diagnosed in Wujin People’s Hospital from January 2014 to December 2019. According to whether they were finally diagnosed with myocardial damage, they were divided into 29 cases in group A (with myocardial damage) and 51 cases in group B (without myocardium). Injury), 60 patients with common pneumonia during the same period were selected as the control group; the peripheral blood RDW and serum cTnI levels of the three groups were compared. Results  The RDW and cTnI test results of group A patients were significantly higher than those of group B and control group, and the difference was statistically significant (P<0.05); There was no statistically significant difference in RDW and cTnI between group B and the control group (P>0.05); Using ROC curve analysis, the results showed that the sensitivity of RDW in diagnosing severe pneumonia patients with myocardial damage was 88.51%, the specificity was 76.29%, and the AUC value was 0.846; the sensitivity of cTnI in diagnosing severe pneumonia patients with myocardial damage was 94.20% and the specificity was 86.44 %, the AUC value is 0.903; The sensitivity of cTnI combined with RDW in diagnosing severe pneumonia patients with myocardial damage was 98.28%, specificity was 92.01%, and the AUC value was 0.951. Conclusion. Patients with severe pneumonia may be complicated with myocardial injury. The combination of cTnI and RDW examination has certain guiding value for early diagnosis and has guiding significance for clinical treatment.
2020 Vol. 27 (36): 56-59 [Abstract] ( 30 ) HTML (1 KB)  PDF  (0 KB)  ( 14 )
60 Clinical observation of direct feeding instruction combined with transcranial direct current stimulation in the treatment of dysphagia after stroke and its influence on the degree of aspiration
HUA He-liu ZHANG Bai-xiang LIU Juan TANG Neng-zhang WANG Xiu-ling CHEN Ning-hua
Objective To explore the clinical effect of direct feeding instruction combined with transcranial direct current stimulation in the treatment of dysphagia after stroke and its influence on the degree of aspiration.Methods Eighty patients with dysphagia after stroke admitted to Longyan First Hospital Affiliated to Fujian Medical University from November 2017 to December 2019 were selected as the research objects.According to the random envelope method,they were divided into the observation group (40 cases) and the control group (40 cases).The control group adopted the direct feeding instruction method,and the observation group adopted the direct feeding instruction combined with transcranial direct current stimulation.The total effective rate of treatment,scores of the modified Mann swallowing ability assessment scale (MMASA),the functional food intake scale (FIOS),and the occurrence of eating and drinking aspiration were compared between the two groups..Results The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant (P<0.05).After treatment,the MMASA and FIOS scores of the observation group were higher than those in the control group,and the differences were statistically significant (P<0.05).The rates of water aspiration,food aspiration and total aspiration of the observation group were lower than those of the control group,and the differences were statistically significant (P<0.05).Conclusion The combination of direct feeding guidance and transcranial direct current stimulation for treating patients with dysphagia after stroke can effectively improve their swallowing function and significantly reduce the incidence of aspiration in patients
2020 Vol. 27 (36): 60-63 [Abstract] ( 35 ) HTML (1 KB)  PDF  (0 KB)  ( 12 )
64 Clinical effect of ambroxol hydrochloride in the treatment of chronic obstructive pulmonary disease with pulmonary infection
Tan Xueting； Lin Caizhan；Zhong Xiaona

Objective: To investigate the clinical effect of ambroxol hydrochloride in the treatment of chronic obstructive pulmonary disease complicated with pulmonary infection. Methods: From February 2019 to February 2020,300 patients with chronic obstructive pulmonary disease and pulmonary infection were selected, The observation group was treated with ambroxol hydrochloride (150 cases), routine treatment in the control group (150). The clinical curative effect, the incidence of adverse reactions, the time of disappearance of clinical symptoms and signs, and the quality of life were compared and analyzed. Results：97.33% of clinical efficacy in observation group was higher than 85.33% in control group, The incidence of adverse reactions was 6.67% lower than 7.33% in the control group, but not statistically significant (P>0.05); Chest tightness and temperature recovery in the observation group, And lung rales, cough disappeared time shorter than the control group (P<0.05); Compared to the control group, All the quality of life scores in the observation group were higher (P<0.05). Conclusion: For patients with chronic obstructive pulmonary disease complicated with pulmonary infection, With ambroxol hydrochloride, Safe and effective, Can achieve remarkable therapeutic effect, No adverse reactions, Shorten chest tightness recovery, lung rales and cough loss, It has clinical application value.
2020 Vol. 27 (36): 64-66 [Abstract] ( 30 ) HTML (1 KB)  PDF  (0 KB)  ( 14 )
67 Effect of modified Jianpi Shugan Decoction combined with Entecavir in treatment of decompensated cirrhosis
ZHANG Yu； KE Hua-jing；WU Gang
Objective To investigate the effect of modified Jianpi Shugan Decoction combined with Entecavir in treatment of decompensated cirrhosis.Methods A total of 160 patients with decompensated cirrhosis who were admitted to the First People′s Hospital of Jiujiang City in Jiangxi Province from May 2017 to June 2019 were selected as the research subjects.All the patients were divided into control group (80 cases) and observation group (80 cases) according to the random number table method.The control group was treated with Entecavir,while observation group was treated with modified Jianpi Shugan Decoction combined with Entecavir.The total effective rate,traditional Chinese medicine(TCM) syndrome score,liver function indexes (aspartate aminotransferase [AST],alanine transaminase [ALT],total bilirubin [TBil],albumin [ALB]) before and after treatment,and the incidence of adverse reactions were compared between the two groups..Results The total effective rate of the observation group was higher than that of the control group,with statistical difference (P<0.05).The TCM syndrome score of the observation group was lower than that of the control group after treatment,with statistical difference (P<0.05).The levels of AST,ALT,TBil,ALB and HBV-DNA in the observation group were lower than those in the control group after treatment,with statistical differences (P<0.05).No obvious adverse reactions occurred during the two groups of medication.Conclusion Modified Jianpi Shugan Decoction combined with Entecavir in treatment of patients with decompensated cirrhosis is effective,it can decrease TCM syndrome score,improve indexes of liver function,and have no obvious adverse reactions,which has high safety and is worthy of promotion and application.
2020 Vol. 27 (36): 67-69转73 [Abstract] ( 28 ) HTML (1 KB)  PDF  (0 KB)  ( 11 )
70 Risk factors of chronic obstructive pulmonary disease combined with peripheral vascular disease
DU Shu-wei
Objective To explore the risk factors of chronic obstructive pulmonary disease complicated with peripheral vascular disease.Methods A retrospective analysis was carried out on 80 patients with chronic obstructive pulmonary disease in Shenyang First People′s Hospital who received peripheral vascular disease-related examinations from December 2016 to December 2019 were choosed.40 patients diagnosed with definite peripheral vascular disease were the onset group,and 40 patients excluded from peripheral vascular disease were the non-onset group.The influence of gender,age,smoking history,drinking history,hypertension,pulmonary heart disease,type 2 diabetes,hyperlipidemia and coronary heart disease on the incidence of chronic obstructive pulmonary disease combined with peripheral vascular diseases were analysed..Results The results of single factor analysis showed that there were significant differences in smoking history,drinking history,hypertension,pulmonary heart disease,type 2 diabetes,hyperlipidemia and coronary heart disease (P<0.05).Multivariate analysis showed that smoking history (β=2.349,OR=2.819,95%CI=1.219-3.408),hypertension (β=1.833,OR=5.167,95%CI=1.035-5.457),pulmonary heart disease (β=2.925,OR=5.868,95%CI=1.596-6.245),type 2 diabetes mellitus (β=1.712,OR=5.523,95%CI=2.102-7.836) and hyperlipidemia (β=1.293,OR=2.446,95%CI=1.381-4.319) were independent risk factors for the onset of chronic obstructive pulmonary disease combined with peripheral vascular disease (P<0.05).Course of disease complicated with type 2 diabetes,course of disease complicated with hypertension,course of disease complicated with hyperlipidemia,course of disease complicated with pneumonia heart disease and course of disease complicated with coronary heart disease were positively correlated with the prevalence rate of chronic obstructive pulmonary disease combined with peripheral vascular disease (P<0.05).Conclusion Smoking history,hypertension,pulmonary heart disease,type 2 diabetes,hyperlipidemia and coronary heart disease are the relevant and independent risk factors for the occurrence of chronic obstructive pulmonary disease combined with peripheral vascular disease,and the course of disease is positively correlated with the prevalence rate of chronic obstructive pulmonary disease combined with peripheral vascular disease.
2020 Vol. 27 (36): 70-73 [Abstract] ( 31 ) HTML (1 KB)  PDF  (0 KB)  ( 10 )
74 Test result comparison of bone marrow morphology between refractory anemia and megaloblastic anemia
ZHANG Ying
Objective To compare the results of bone marrow morphology of refractory anemia and megaloblastic anemia.Methods A total of 50 patients with refractory anemia in Baotou Tumor Hospital from January 2017 to December 2019 were selected as the refractory anemia group,and 50 patients with megaloblastic anemia Baotou Tumor Hospital were selected as the megaloblastic anemia group at the same time.Both groups received bone marrow morphology test and made a comparative analysis..Results The positive rate of periodate-alkaline red staining (PAS) of nucleated red blood cells in the refractory anemia group was higher than that in the megaloblastic anemia group,the differences were statistically significant (P<0.05); the rates of lymphoid small megakaryocytes and erythropathy in the refractory anemia group were higher than those in the megaloblastic anemia group,the differences were statistically significant (P<0.05);the incidence of granulomegaly in the refractory anemia group was higher than that in the megaloblastic anemia group,the differences were statistically significant (P<0.05); the volume of megaloblastic primordial erythrocytes and megaloblastic early erythrocytes in the refractory anemia group were smaller than those in the megaloblastic anemia group,the differences were statistically significant (P<0.05).Conclusion Application of bone marrow morphologic test in differential diagnosis of refractory anemia and megaloblastic anemia,especially the phenomenon of lymphoid small megakaryocyte.Secondly,according to the characteristics of megaloblastic anemia,the operator should focus on the detection of megaloblastic red blood cell volume,and at the same time,the positive rate of PAS of nucleated red blood cells can be used as the clinical basis for differential diagnosis of refractory anemia and megaloblastic anemia.
2020 Vol. 27 (36): 74-76 [Abstract] ( 27 ) HTML (1 KB)  PDF  (0 KB)  ( 11 )
77 Analysis of 25 hydroxyvitamin D level and its related factors in patients with maintenance peritoneal dialysis
LIN Teng-qiang ；MAO Shi-qing ；YE Xiao-yi
Objective To explore the serum levels of 25-vitamin D[25(OH)D]and its related factors in patients with maintenance peritoneal dialysis.Methods A total of 69 patients with maintenance peritoneal dialysis managed by peritoneal dialysis clinic of Mindong Hospital Affiliated to Fujian Medical Universitywere selected from April to June in 2019.Collect the patient′s gender,age,primary disease,serum 25(OH)D hemoglobin (HGB),albumin (ALB),triglyceride (TG),total cholesterol (TC),high density lipoprotein cholesterol (HDL-C),low density lipoprotein cholesterol (LDL-C),Apolipoprotein A1 (Apo A1),apolipoprotein B (Apo B),serum creatinine (Cr),blood urea (BUN),blood calcium (Ca),blood phosphorus (P),whole parathyroid hormone (iPTH) And other clinical data for retrospective analysis and relevant factor analysis..Results The serum 25(OH)D level of 69 patients was （11.90±4.34）ng/mL,serum 25(OH)D<15 ng/mL were the standard of vitamin D deficiency,they were divided into two groups,of which 55 cases (79.7%) in vitamin D deficiency group,serum 25(OH)D level was (10.2±2.7)ng/mL; in the non-deficiency group,14 patients (20.3%) had a blood 25 (OH)D level of (18.7±2.6) ng/mL.The proportion of women in vitamin D deficiency group,TC level,Apo B level were higher than those in the non-deficiency group,ALB level was lower than those in the non-deficiency group,the differences were statistically significant (P<0.05); there were no significant difference in age,HGB,TG,HDL-C,LDL-C,Apo A1,Cr,BUN,Ca,P,iPTH and other indicators between the two groups (P>0.05).Multiple linear regression analysis showed that ALB level(β=0.493,P=0.002) and gender (β=-2.989,P=0.004) were independent influencing factors of 25(OH)D level.Conclusion The level of 25(OH)D in patients with maintenance peritoneal dialysis is obviously insufficient,most of them are in the lack of level,and the vitamin D deficiency is more serious in patients with hypoalbuminemia.It is suggested that improving malnutrition in patients with peritoneal dialysis may reduce the status of vitamin D deficiency.
2020 Vol. 27 (36): 77-79 [Abstract] ( 32 ) HTML (1 KB)  PDF  (0 KB)  ( 18 )
80 A comparative study of the diseased locations of unilateral and bilateral upper urinary tract stones in adult patients
HUANG Xiao-wei
Objective To understand the differences of the diseased locations in adults with unilateral or bilateral upper urinary tract stones.Methods From January to October 2019,447 adult outpatients diagnosed with upper urinary tract stones in Panyu Hospital of Chinese Medicine were enrolled as the study sample.The questionnaire was used to record patients′ daily eating habits and calculus location..Results The prevalence of bilateral upper urinary tract stones in males (44.7%) was higher than that in females (28.8%),the difference is statistically significant (P<0.05); the prevalence of bilateral upper urinary tract stones in males was higher than left or right side stones (SR=3.5,|SR|>3),and the difference is statistically significant difference (P<0.05); in the unilateral upper urinary tract stones cases in both sexes,the left side was more common,but there was no significant difference (P>0.05); the risk of bilateral upper urinary tract stones in male was significantly higher than female (RR=1.555,95%CI=1.207-2.002,P<0.05).Conclusion The prevalence of unilateral upper urinary tract stones in adult patients is higher than bilateral; the left side stones are more common than the right side in the unilateral upper urinary tract stones patients; the prevalence of bilateral calculi in males is higher than females.It suggests that gender differences could be one of the factors that affect the formation and progression of kidney stones.
2020 Vol. 27 (36): 80-83 [Abstract] ( 29 ) HTML (1 KB)  PDF  (0 KB)  ( 9 )
84 Clinical effect of varicocele ligation under microscope to treat varicocele
HU Xiao； YI Ai-guo； XU Wen-yuan ；ZHOU Qin
Objective To explore the clinical effect of varicocele ligation under microscope to treat varicocele.Methods A total of 56 patients with varicocele treated in the Second People′s Hospital of Yichun from January 2018 to September 2019 were selected as the research object,and the patients were divided into observation group (24 cases)and control group (32 cases) by the different treatment method.The control group was treated with spermatic vein ligation under the microscope,and the observation group was treated with high ligation of the spermatic vein under the laparoscope.The operation time,intraoperative testicular artery retention rate,postoperative sheath effusion,semen quality improvement rate,recurrence rate of postoperative varicocele,sperm concentration,and total sperm vitality were compared between the two groups..Results The operation time of the observation group was shorter than that of the control group,the difference was statistically significant (P<0.05).The retention rate of testicular artery and the improvement rate of semen quality in the observation group were higher than those of the control group,the differences were statistically significant (P<0.05).The incidence of postoperative sheath fluid accumulation and recurrence rate of varicocele in the observation group were lower than those of the control group,the differences were statistically significant (P<0.05).Six months after operation,the sperm concentration and the total sperm vitality in the observation group were higher than those of the control group,the differences were statistically significant (P<0.05).Conclusion Microscopically ligation of spermatic vein has an ideal therapeutic effect on patients with varicocele and can be widely used in clinic.
2020 Vol. 27 (36): 84-86转93 [Abstract] ( 35 ) HTML (1 KB)  PDF  (0 KB)  ( 12 )
87 Effect of transcatheter arterial chemoembolization after hepatectomy on serum tumor markers in liver cancer patients
LUO Yong-ping ；OU Yi-meng；YU Jiong-biao
Objective To investigate the effect of transcatheter arterial chemoembolization (TACE) after hepatectomy on serum tumor markers in liver cancer patients.Methods A total of 78 patients with primary liver cancer admitted in The First Affiliated Hospital of Clinical Medicine of Guangdong Pharmaceutical University from February 2018 to February 2019 were selected as the research objects,and they were divided into the study group and the control group by the drawing lots method,with 39 cases in each group.The control group was performed with routine hepatectomy.The study group was treated with TACE after hepatectomy.The changes of serum tumor markers such as carcinoembryonic antigen (CEA),alpha-fetoprotein (AFP),alpha-fetoprotein heterojunction (AFP-L3) and glypican-3 (GPC3) before and after treatment were measured and compared between the two groups.And the recurrence rate of the two groups was counted for one year..Results Comparison of four serum tumor markers including CEA,AFP,AFP-L3 and GPC3 between the two groups before treatment,The differences were not statistically significant (P>0.05).The CEA,AFP,AFP-L3 and GPC3 levels of the two groups were lower than those before treatment,the differences were statistically significant (P<0.05).The CEA,AFP,AFP-L3 and GPC3 levels of the study group were lower than those of the control group,the differences were statistically significant (P<0.05).The 1 year recurrence rate in the study group was lower than that in the control group,the difference was statistically significant (P<0.05).Conclusion After hepatectomy,TACE for patients with primary liver cancer can play a more significant role in reducing serum tumor markers,and the recurrence rate of the patients is relatively low,so clinical application has important clinical significance.
2020 Vol. 27 (36): 87-89转97 [Abstract] ( 32 ) HTML (1 KB)  PDF  (0 KB)  ( 14 )
90 Influence of Mutouhui extract on the function of myeloid dendritic cells from acute myeloid leukemia complete remission patients
WANG Yu-hong； XIA Xiao-jun；CUI Jie ；JIANG Jun-feng ；DUAN Yun
Objective To analyze the promoting maturation effect of Mutouhui (MTH) extract on acute myeloid leukemia (AML) bone marrow-derived dendritic cells (DC) of complete remission (CR) patients,and to explore the mechanism of MTH in the treatment of minimal residual leukemia.Methods The bone marrow mononuclear cells of AML CR patients were isolated and grouped after DC was inducted,which were divided into the control group,the LPS group,the MTH polysaccharide group,the MTH terpenoids group and the MTH saponins group.After 2 hours of culture,DC was observed under inverted microscope.The expression of DC surface molecules was detected by flow cytometry,and IL-12 level in DC supernatant was detected by ELISA..Results DC was promoted maturation by MTH polysaccharides and terpenoids.The expressions of CD80,CD83,CD86,CD1a and HLA-DR were higher than those of the negative control group,with statistically significant (P<0.05).The level of IL-12 was secreted by maturation DC with MTH polysaccharide and terpene promoting,which was higher than that of the negative control group,with statistically significant (P<0.05).Conclusion The polysaccharides and terpenoids of MTH can promote maturation and immune function of DC from AML CR patients.
2020 Vol. 27 (36): 90-93 [Abstract] ( 28 ) HTML (1 KB)  PDF  (0 KB)  ( 16 )
94 Clinical effect of Pseudomonas Aeruginosa Injection combined with Cisplatin and local hyperthermia in the treatment of cancerous ascites
WANG Cui-hong； SHI Wen-kui；WANG Mao-mao； FAN Yu-fei
Objective To observe the clinical efficacy of Pseudomonas Aeruginosa Injection combined with Cisplatin and local hyperthermia in the treatment of cancerous ascites.Methods A total of 58 patients with cancerous ascites admitted to Beijing Yanhua Hospital from June 2016 to June 2019 were selected as the research objects,and they were divided into group A (19 cases),group B (19 cases) and group C (20 cases) according to the random number table method.After adequate drainage of ascites,group A was treated with Cisplatin,group B was received local hyperthermia after one hour of Cisplatin perfusion,while group C was treated with local hyperthermia one hour after infusion of Cisplatin,and was perfused with Pseudomonas Aeruginosa Injection three days later.Two weeks were a treatment cycle,totally two cycles after apart seven days.The ascites reduction,functional state score (KPS) and adverse reactions were assessed one month later..Results The total effective rate of ascites reduction in group C was higher than that in group A,the difference was statistically significant (P<0.05).The KPS score of group C after treatment was higher than that of group A,the difference was statistically significant (P<0.05).The improvement rate of KPS in group C was higher than that in group A,the difference was statistically significant (P<0.05).There were no significant difference in the total incidence of adverse reactions between group A and group B compared with group C (P>0.05),and there was no significant difference in the total incidence of adverse reactions between group A and group B (P>0.05).Conclusion Pseudomonas Aeruginosa Injection combined with Cisplatin and local hyperthermia has a good clinical effect in the treatment of cancerous ascites,and it can improve the functional status of patients.
2020 Vol. 27 (36): 94-97 [Abstract] ( 32 ) HTML (1 KB)  PDF  (0 KB)  ( 14 )
98 Analysis on related factors of perinatal death in Fujian Province 2019
LIN Ying-ying；ZHANG Rong-hua；XIU Xiao-yan； CHEN Rong； LIN Li-hua； LIN Juan
Objective To analyze the perinatal mortality and related factors in Fujian Province in 2019.Methods Clinical data of perinatal infants were selected from 103 hospitals,which were in the birth defect monitoring system of Fujian Province from January to December 2019.And all perinatal death cases collected by the Three-level Maternal and Child Health Network were statistically analyzed..Results A total of 274 815 perinatal infants were monitored in 2019,and the number of perinatal deaths were 1186 and perinatal mortality rate was 4.32‰.Stillbirth was accounted for the first place with 1024 cases (86.3%),followed by early neonatal deaths with 162 cases (13.7%).Perinatal death was related to maternal age,number of fetuses,and birth defects.Elderly or young maternal,twins and multiple births,and combined with birth defects could increase perinatal mortality,the differences were statistically significant (χ2=31.581,46.431,3872.513,P<0.001).The main causes of perinatal death were birth defects,premature birth,umbilical cord factors,birth asphyxia and placental factors.Conclusion Birth defects are an important cause of perinatal death in our province.The key measures to reduce perinatal mortality are listed in the following,including carrying out pre-marital health check and pre-pregnancy health check,improving the level of prenatal screening and diagnosis,early detection,early diagnosis,and timely termination of pregnancy to reduce the occurrence of fatal birth defects.At the same time,it is important to strengthen the collaboration between perinatal care and obstetrics,timely identify and handlle high-risk pregnancies,reduce the occurrence of premature birth and birth asphyxia.
2020 Vol. 27 (36): 98-101 [Abstract] ( 33 ) HTML (1 KB)  PDF  (0 KB)  ( 16 )
102 Effect of exercise prescription on physical health of preschool children
ZENG Jie ；XIE Jie-yan； YAN Xue-qin
Objective To explore the influence of physical activity of preschool children on their physical health in Zhongshan City.Methods Retrospectively analyzed the data of 90 preschool children in two middle classes of a kindergarten in Zhongshan City from January to December in 2018,they were divided into a control group (45 children) and a research group (45 children) according to different teaching methods.The control group used conventional teaching activities,and the research group used conventional teaching activities combined with exercise prescription method.The changes of physical fitness indexes (height,weight,10 m round-trip running,standing long jump,tennis throw,double foot continuous jump,sit forward flexion,balance beam) were compared respectively between the two groups of boys and girls before and after the intervention..Results Before the intervention,there were no significant differences in the scores of physical fitness indexes between the two groups (P>0.05).There were no significant differences in the scores of physical fitness indexes between boys and girls in the control group before and after the intervention (P>0.05).After the intervention,the index scores of height,10 m round-trip running,standing long jump,tennis throw,double foot continuous jump,sitting forward flexion and balance beam in the research group were higher than those before the intervention,and were higher than those in the control group,the differences were statistically significant (P<0.05).There were no significant differences in the body weight scores of boys and girls in the research group before and after the intervention (P>0.05),and there were no significant differences between the two groups after intervention (P>0.05).Conclusion Intervening preschool children with exercise prescriptions to intervene their physical behaviors can improve the physical health of preschool children.
2020 Vol. 27 (36): 102-105 [Abstract] ( 28 ) HTML (1 KB)  PDF  (0 KB)  ( 13 )
106 Effect of three sequential therapy on children with Mycoplasma pneumoniae pneumonia
LI Yan-li ；SHANG Ying ；WANG Zeng-hui ；HONG Qian
Objective To explore the effect of three sequential therapies consisting of Erythromycin,Azithromycin and Erythromycin combined with Azithromycin in the treatment of Mycoplasma pneumoniae pneumonia in children.Methods Retrospectively analyzed the clinical data of 150 children with Mycoplasma pneumoniae pneumonia admitted to the PLA 71st Army Group Hospital from October 2017 to July 2019.According to the medication plan,they were divided into the Erythromycin sequential therapy (HMS) group,the Azithromycin sequential therapy (AQMS) group and the Erythromycin-Azithromycin sequential therapy (HMS-AQMS) group,with 50 cases in each group.In HMS group,Erythromycin was given orally for 3 d after 7 d of intravenous drip.In AQMS group,Azithromycin was given intravenously for 5 d and stopped for 3 d,then orally for 5 d.In HMS-AQMS group,Erythromycin was given intravenously for 7 d and then Azithromycin was given orally for 3 d.The symptoms,signs,X-ray changes,clinical efficacy and adverse reactions of the three groups were compared..Results There were no significant differences in the time of fever abatement,cough disappearance,pulmonary rales disappearance and X-ray examination recovery time among the three groups (P>0.05).The total effective rate of HMS-AQMS group was 96.0%,which was higher than that of HMS group(86.0%) and AQMS group (88.0%),the difference was statistically significant (P<0.05).There was no significant difference in the total incidence of adverse reactions among the three groups (P>0.05).Conclusion Erythromycin-Azithromycin continuous therapy in the treatment of children with Mycoplasma pneumoniae pneumonia has better curative effect and lower adverse reactions,so it is worthy of promotion and application in clinical practice.
2020 Vol. 27 (36): 106-108转112 [Abstract] ( 27 ) HTML (1 KB)  PDF  (0 KB)  ( 19 )
109 Clinical effect of laparoscopy combined with hysteroscopy in the treatment of cesarean scar pregnancy
DONG Jun-xiao； HAN Yu-ying ；WANG Qing-yi
Objective To explore the clinical effect of laparoscopy combined with hysteroscopy in the treatment of cesarean scar pregnancy.Methods Retrospective analysed the clinical data of 66 patients who were treated in Zhuhai Hospital of Integrated Traditional Chinese and Western Medicine from January 2016 to January 2020,they were divided into a treatment group and a control group according to different surgery operation,33 cases in each group.The treatment group was treated with laparoscopy combined with hysteroscopy,the control group was treated with transvaginal operation.The operation time,intraoperative blood loss,the time when serum human chorionic gonadotropin(β-hCG) decreased to normal,the first normal menstruation time and hospitalization time were compared between the two groups..Results The operation time and hospitalization time of the treatment group were shorter than those of the control group,and the intraoperative blood loss was less than that of the control group,the differences were statistically significant (P<0.05).There were no significant differences in the first normal menstrual time and serum β-hCG recovery time between the two groups (P>0.05).Conclusion Laparoscopy combined with hysteroscopy in the treatment of cesarean scar pregnancy has the advantages of less blood loss,short operative time and short hospital stay.At the same time,it can repair the morphology of the uterus and retain the fertility function.It is a feasible treatment method,which is worthy of clinical application
2020 Vol. 27 (36): 109-112 [Abstract] ( 28 ) HTML (1 KB)  PDF  (0 KB)  ( 9 )
113 Effect comparison of Erythromycin and Azithromycin in the treatment of Mycoplasma pneumoniae pneumonia in children
LI Jing
Objective To compare the effect of Erythromycin and Azithromycin in the treatment of Mycoplasma pneumoniae pneumonia in children.Methods A total of 60 children with Mycoplasma pneumoniae pneumonia who admitted to Maternal and Child Health Hospital in Ganzhou City of Jiangxi Province from June 2018 to June 2019 were selected as the research objects and divided into the control group and the experimental group according to the random number table method,with 30 cases in each group.The children in the control group were treated with Erythromycin,and the children in the experimental group were treated with Azithromycin.The antipyretic time,hospitalization time,total effective rate and total incidence of adverse reactions of the two groups were compared..Results The antipyretic time and hospitalization time in the experimental group were shorter than those in the control group,and the differences were statistically significant (P<0.05).The total effective rate of the experimental group was higher than that of the control group,and the difference was statistically significant (P<0.05).The total incidence of adverse reactions in the experimental group was lower than that in the control group,and the difference was statistically significant (P<0.05).Conclusion Azithromycin is more effective in the clinical treatment of Mycoplasma pneumoniae pneumonia in children.Rational use of Azithromycin can improve the safety of the drug and reduce the adverse reactions of the drug as much as possible.It has important clinical value for physical recovery of children and is worth of promotion and application.
2020 Vol. 27 (36): 113-115 [Abstract] ( 29 ) HTML (1 KB)  PDF  (0 KB)  ( 9 )
116 Analysis of high risk factors and pregnancy outcome of fetal growth restriction
FAN Xiao-yan； ZHOU Yan-ping
 Objective To explore the high-risk factors and prognosis of fetal growth restriction (FGR),so as to provide reference for prenatal consultation and treatment.Methods A total of 80 pregnant women with FGR admitted to Suzhou Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine from January 1,2013 to December 31,2019 were selected as the observation group,and 80 pregnant women without FGR were selected as control group.The clinical data of the two groups were observed,and the high-risk factors and pregnancy outcomes of the two groups were analyzed..Results The maternal factors (pregnancy induced hypertension,twins,intrahepatic cholestasis of pregnancy,oligohydramnios),umbilical cord abnormality,placental abnormalities in the observation group were higher than those in the control group,the differences were statistically significant (P<0.05).The rate of neonatal asphyxia,incidence of related complications,mortality and stillbirth rate in the observation group were higher than those in the control group,the differences were statistically significant (P<0.05).Conclusion Maternal factors,placentas and umbilical cord factors are the high risk factors of fetal growth restriction.It is suggested that strict screening should be carried out in clinical antenatal examination,the propaganda and education of prenatal examination knowledge of pregnant women should be strengthened,and prenatal nutrition guidance service should be provided to promote the smooth progress of eugenics and eugenics.
2020 Vol. 27 (36): 116-118 [Abstract] ( 32 ) HTML (1 KB)  PDF  (0 KB)  ( 11 )
119 Clinical characteristics of sudden sensorineural hearing loss in pregnancy and therapeutic effect of intratympanic Dexamethasone
PENG Cheng； CHEN Hua； LI Ze-qun
Objective To analyze the clinical characteristics of sudden sensorineural hearing loss (SSNHL) during pregnancy and evaluate the therapeutic effect of intratympanic Dexamethasone.Methods Retrospectively analyzed the clinical data of 31 SSNHL patients(31 ears)during pregnancy(pregnancy group)and 102 age-matched SSNHL patients(nonpregnancy group) treated in Xiangxi Tujia and Miao Qutonomous Prefecture People′s Hospital between January 2008 and May 2018,the characteristics and prognosis between the two groups were compared.The pregnancy group was further divided into intratympanic injection group (16 ears) and non-intratympanic injection group (15 ears) according to whether receiving intratympanic Dexamethasone,and the therapeutic effect was evaluated..Results In the pregnancy group,the initial hearing threshold was higher than that in the non-pregnancy group,and the duration from onset to treatment is shorter than that in the non-pregnant group,the differences were statistically significant (P<0.05).There were no significant differences in the complete recovery rate,marked recovery rate,recovery rate,no recovery rate and hearing threshold improvement between the two groups (P>0.05).In the intratympanic injection group,the hearing threshold improvement was higher than that in the non-intratympanic injection group,the difference was statistically significant (P<0.05).Conclusion SSNHL patients during pregnancy suffered a severe hearing loss with a short duration from onset to treatment.SSNHL patients with pregnancy and without pregnancy got similar hearing results,and intratympanic Dexamethasone is an effective therapy for SSNHL patients with pregnancy.
2020 Vol. 27 (36): 119-122 [Abstract] ( 28 ) HTML (1 KB)  PDF  (0 KB)  ( 11 )
123 Effect of capsular tension ring on visual acuity,intraocular pressure and complications in patients with subluxation of lens
WU Bo-xi
Objective To investigate the effect of capsular tension ring (CTR) on visual acuity,intraocular pressure and complications of patients with subluxation of lens.Methods A total of 80 patients with subluxation of lens who were admitted to the Department of Ophthalmology in Shenyang 4th People′s Hospital of from May 2015 to March 2020 were selected as the research objects,they were divided into a control group (40 cases,73 eyes) and an observation group(40 cases,72 eyes) according to the random number table method.The control group received phacoemulsification combined with intraocular lens implantation (Phaco + IOL),and the observation group received CTR on the basis of the control group.The intraocular pressure,visual acuity level and postoperative complications were compared between the two groups before and 3 months after operation..Results There were no significant differences in the intraocular pressure and visual acuity level between the two groups before operation (P>0.05).There months after operation,the intraocular pressure of both groups were lower than those before operation,and the visual acuity levels of both groups were higher than those before operation,the differences were statistically significant (P<0.05).There months after operation,the intraocular pressure of the observation group was lower than that of the control group,and the visual acuity level was higher than that of the control group,the differences were statistically significant (P<0.05).The total postoperative complication rate of the observation group was 9.72%,which was lower than 21.92% in the control group,the difference was statistically significant (P<0.05).Conclusion For patients with subluxation of lens,adjuvant treatment CTR besides Phaco+IOL surgery has a remarkable effect,which can effectively reduce intraocular pressure,improve visual acuity,and decrease postoperative complications.
2020 Vol. 27 (36): 123-125 [Abstract] ( 33 ) HTML (1 KB)  PDF  (0 KB)  ( 12 )
126 Value analysis of ultrasound BI-RADS classification in identifying the nature of breast mass
ZHANG Yan；CHENG Tian-peng；QIU Shao-hui
 Objective To investigate the value of ultrasound breast imaging-reporting and data system (BI-RADS) classification in differential diagnosis of breast mass.Methods The clinical data of 628 patients with breast mass who admitted to the First People′s Hospital of Jingdezhen City from June 2015 to June 2017 were retrospectively analyzed.The ultrasound examination was performed,and the lesions of patients were classified according to ultrasound BIRADS criteria.A total 100 patients with BI-RADS grade 3 and above were selected as the research objects,and the pathological diagnosis results were used as the gold standard.The benign and malignant proportions of 100 patients were recorded,and the diagnosis value of ultrasound BI-RADS in the patients with BI-RADS grade 3 and above and misdiagnosis of ultrasound BI-RADS was analyzed.The ultrasound image features of benign and malignant masses were compared..Results The sensitivity,specificity and accuracy of patients with ultrasound BI-RADSgrade 4 were 100.00%,0.00%,100.00%.The sensitivity,specificity and accuracy of patients with ultrasound BI-RADS grade 4 were 100.00%,72.00%,76.67%.Among 100 lesions,the lesions diagnosed as benign by ultrasound and malignant by pathology were intraductal papilloma,adenopathy,and fibroadenoma.The proportion of low internal echo,abundant blood supply and axillary lymph node enlargement of malignant masses were higher than those of benign masses,the proportion of regular morphology,clear border and complete tissue of malignant masses were lower than those of benign masses,and the differences were statistically significant (P<0.05).Conclusion Ultrasound BI-RADS classification has good differential diagnosis value for breast masses.The benign and malignant masses have large differences in ultrasound performance,it can provide effective guidance for the development of treatment plans and reduce misdiagnosis,which is worthy of clinical promotion and application.
2020 Vol. 27 (36): 126-128 [Abstract] ( 29 ) HTML (1 KB)  PDF  (0 KB)  ( 12 )
129 Value of ultrasound in diagnosis of fetal congenital imperforate anus and the normal measurement of the anus in ultrasound obstetric screening
HU Bo ；LAI Gan-ping； WANG Ying； LIN Qiong
Objective To investigate the value of ultrasound in diagnosis of fetal congenital imperforate anus and the normal measurement of the anus in ultrasound obstetric screening.Methods The clinical data of 6000 fetuses with a gestational age of 20 weeks or above admitted to Ganzhou Maternal and Child Health Hospital of Jiangxi Province from October 2016 to July 2019 were retrospectively analyzed.Prenatal ultrasound diagnosis was analyzed,and the ultrasound diagnosis results of the fetuses and the sonographic appearance of anal sphincter,the correlation between anal sphincter diameter,circumference,and area measurement in healthy fetuses and gestational age were observed..Results Among the 6000 fetuses,5996 of them had anal target sign,and the other 4 cases did not detect this sign,and they were all confirmed to be imperforate anus after induction,abortion or delivery,including 1 case of simple atresia,3 cases of other malformations and abnormalities.The anal sphincter diameter,circumference,and area in healthy fetuses were positively correlated with gestational age (P<0.05).Conclusion Ultrasound diagnosis has a high value in fetal congenital imperforate anus and normal measurement of anus in obstetric screening.However,it is still necessary to strengthen the improvement of ultrasound diagnosis and improve the ability of inspectors to increase the diagnosis rate.
2020 Vol. 27 (36): 129-131转144 [Abstract] ( 30 ) HTML (1 KB)  PDF  (0 KB)  ( 8 )
132 Application of mammography combined with ultrasound in early breast cancer screening
YUAN Fang； LI Ning-shan； HUANG Xue
Objective To explore the application of mammography combined with ultrasound in early breast cancer screening.Methods A total of 54 female patients who were screened for early breast cancer in Xinqiao Hospital of Chinese People′s Liberation Army Military Medical University from January 2018 to January 2019 were selected as the research objects and examined by breast ultrasound and mammography.The pathological results were taken as the judgment criteria.The accuracy of breast ultrasound,mammography and mammography combined with ultrasound in early breast cancer screening and the situation of lesions were compared..Results The results and the accuracy of detection of lesion size of mammography combined with ultrasound were higher than those of mammography alone or ultrasound alone,and the differences were statistically significant (P<0.05).There were no statistically significant differences in the results and the accuracy of the size of the lesions of mammography combined with ultrasound and clinical pathology (P>0.05).Conclusion The mammography combined with ultrasound is effective in early breast cancer screening,which can significantly improve the accuracy of screening and provide clinical reference for early clinical treatment.
2020 Vol. 27 (36): 132-134 [Abstract] ( 29 ) HTML (1 KB)  PDF  (0 KB)  ( 11 )
135 Value of Adler classification of color Doppler blood flow in the diagnosis of thyroid nodules
ZHANG Yue
Objective To explore the characteristics of high-frequency ultrasound sonograms and color Doppler blood flow Adler classification differences between benign and malignant thyroid nodules and provide a basis for clinical diagnosis and treatment.Methods A total of 500 patients with thyroid nodules who admitted to the Department of Ultrasound in Jinzhou Central Hospital from May 2018 to May 2019 were selected as the research objects and divided into the benign nodule group (269 cases) and the malignant nodule group (231 cases) according to the pathological results.The characteristics of high-frequency ultrasound sonograms (including internal echo,surrounding echo,lymph node metastasis,boundary conditions and microcalcifications) and color Doppler flow Adler grading were compared between the two groups..Results The percentage of low internal echo,no echo around,lymph node metastasis,microcalcification foci and unorganized boundary in the malignant nodule group were higher than those in the benign nodule group,and the differences were statistically significant (P<0.05).The difference of blood flow Adler classification between benign nodule group and malignant nodule group was statistically significant (P<0.05).Conclusion The high-frequency ultrasound image of malignant thyroid nodules has certain characteristics,and the color Doppler ultrasound blood flow Adler classification is significantly different from benign thyroid nodules.
2020 Vol. 27 (36): 135-137 [Abstract] ( 33 ) HTML (1 KB)  PDF  (0 KB)  ( 11 )
138 Application of optical coherence tomography angiography in central exudative chorioretinopathy
SUN Zhu；WU Xuan
Objective To explore the application of optical coherence tomography (OCT) angiography in central exudative chorioretinopathy (CEC).Methods A total of 46 patients (46 eyes) with CEC who admitted to Eye Hospital of Chinese Academy of Chinese Medical Sciences from March 2018 to October 2019 were selected as the research objects and divided into the study group and the conventional group by block randomized grouping method,with 23 cases in each group.The fluorescein fundus angiography (FFA) examination was performed on patients in the conventional group,and the OCT angiography examination was performed on patients in the study group.The total detection rate of CEC examination,the total incidence of adverse reactions after detection,the clarity and the accuracy of detection were compared between the two groups..Results The total detection rate of CEC,the clarity and the accuracy of detection in the study group were higher than those in the conventional group,and the differences were statistically significant (P<0.05).The total incidence of adverse reactions in the study group was lower than that in the conventional group,and the difference was statistically significant (P<0.05).Conclusion OCT angiography has higher application value in the diagnosis of patients with CEC,it can effectively reduce the total incidence of adverse reactions in patients,and has clinical significance.
2020 Vol. 27 (36): 138-140 [Abstract] ( 27 ) HTML (1 KB)  PDF  (0 KB)  ( 11 )
141 Effect of Frangrant Ainsliaea Tablets combined with Medroxyprogesterone and antibacterial drugs on inflammatory factors in patients with endometritis
ZHU Jing
Objective To investigate the effect of Frangrant Ainsliaea Tablets combined with Medroxyprogesterone and antibacterial drugs on inflammatory factors in patients with endometritis.Methods A total of 89 patients with endometritis who admitted to Macheng Maternal and Child Health Hospital from March 2017 to January 2020 were selected as the research objects and divided into the control group (44 cases) and the observation group (45 cases) according to the random number table method.The control group was treated with Medroxyprogesterone and antibacterial drugs,and the observation group was treated with Frangrant Ainsliaea Tablets on the basis of the control group.The traditional Chinese medicine (TCM) syndrome scores (including lower abdominal pain,abnormal banding,persistent hypothermia,lumbosacral pain) and inflammatory factors levels (including tumor necrosis factor-α [TNF-α],interleukin-4[IL-4],C-reactive protein [CRP]) of the two groups before and after treatment were compared..Results After treatment,the abdominal pain,lower belt abnormalities,persistent low fever,lumbosacral pain syndrome scores,and serum TNFα,IL-4,CRP levels of the two groups were lower than those before treatment,and the differences were statistically significant (P<0.05).After treatment,the abdominal pain,lower belt abnormalities,persistent low fever,lumbosacral pain syndrome scores,and serum TNF-α,IL-4,CRP levels of the observation group were lower than those of the control group,and the differences were statistically significant (P<0.05).Conclusion Frangrant Ainsliaea Tablets combined with Medroxyprogesterone and antibacterial drugs have significant effect on the treatment of endometritis,which can reduce the clinical symptoms of patients and regulate the levels of serum inflammatory factors.
2020 Vol. 27 (36): 141-144 [Abstract] ( 34 ) HTML (1 KB)  PDF  (0 KB)  ( 11 )
145 Clinical effect of Metoprolol combined with Trimetazidine in the treatment of coronary heart disease with heart failure
ZHANG Kai ；WANG Xin-wei ；GAO Yu-qiu
Objective to investigate the clinical effect of Metoprolol combined with Trimetazidine on the treatment of coronary heart disease with heart failure.Methods A total of 100 patients with coronary heart disease and heart failure who admitted to Hongqi Hospital Affiliated to Mudanjiang Medical University from February 2017 to February 2018 were selected as the research objects and divided into the study group and the control group according to the random number table method,with 50 cases in each group.The observation group was treated with Metoprolol combined with Trimetazidine,the control group was treated with routine treatment.The cardiac function indexes and clinical effect were compared between the two groups..Results Before treatment,there were no statistically significant differences in heart rate (HR),left ventricular end systolic diameter (LVESD),left ventricular end diastolic diameter (LVEDD) and left ventricular ejection fraction (LVEF) between the two groups (P>0.05).After treatment,the HR,LVESD,LVEDD in the study group were lower than those in the control group,the LVEF was higher than that in the control group,and the differences were statistically significant (P<0.05).After treatment,the HR,LVESD,LVEDD in the two groups were lower than those before treatment,the LVEF was higher than that before treatment,and the differences were statistically significant(P<0.05).The total effective rate of the study group (96.00%[48/50]) was higher than that of the control group (76.00%[38/50]),and the difference was statistically significant (P<0.05).Conclusion The treatment of Metoprolol combined with Trimetazidine in patients with coronary heart disease and heart failure can effectively improve the cardiac function of patients,and achieve very significant clinical effect,which is worthy of clinical promotion and application.
2020 Vol. 27 (36): 145-147 [Abstract] ( 27 ) HTML (1 KB)  PDF  (0 KB)  ( 11 )
148 Effect and safety of Aspirin and Nimodipine in the treatment of migraine
SUN Hui；LUO Shi-shu；WANG Yu-juan
Objective To investigate the effect and safety of Aspirin and Nimodipine in the treatment of migraine.Methods A total of 100 patients with migraine admitted to the hospital from January 2018 to June 2019 were selected as the research objects and divided into the control group and the observation group by random number table method,with 50 patients in each group.The control group was treated with Nimodipine,while the observation group was treated with Aspirin.The total effective rate,adverse reactions,migraine attacks and recurrence rates of the two groups were compared..Results The total effective rate of the observation group (92.00%) was higher that of the control group(72.00%),and the difference was statistically significant (P<0.05).The total incidence of adverse reactions in the observation group (8.00%) was lower than that in the control group (28.00%),and the difference was statistically significant(P<0.05).After treatment,the number of migraine attacks in the observation group was less than that in the control group,duration of migraine in the observation group was shorter than that in the control group,the visual analogue scale (VAS) score of the observation group was lower than that of the control group,and the differences were statistically significant (P<0.05).The recurrence rate of the observation group (4.00%) was lower than that of the control group(20.00%),and the difference was statistically significant (P<0.05).Conclusion For patients with migraine,Aspirin treatment is more effective than Nimodipine,which is suitable for clinical application and promotion.
2020 Vol. 27 (36): 148-150 [Abstract] ( 29 ) HTML (1 KB)  PDF  (0 KB)  ( 10 )
151 Study on the pathological characteristics of gastric mucosa with intestinal metaplasia and correlation of traditional Chinese medicine syndrome
WANG Qing-lian SHAO Yan-feng▲ WANG Jian-ping NING Lu-feng CHEN Wen-hui YE Ting-ting
Objective To explore the classification of pathological changes of chronic atrophic gastritis (CAG) with intestinal metaplasia (IM) and the distribution characteristics of traditional Chinese medicine syndrome.Methods A total of 138 patients with CAG and IM admitted to the Third People′s Hospital of Fujian University of Traditional Chinese Medicine from September 2018 to March 2020 were selected as the research objects.The patient′s gastroscopy,pathological examination and traditional Chinese medicine syndrome elements (position and disease nature) were analyzed and studied..Results In this study,the research data were mainly mild and moderate IM; all patients had gland atrophy,and the gland atrophy was aggravated with IM (P<0.05).Chronic inflammation of the gastric mucosa was polarized,and there was no obvious correlation between the grade of IM and pathological inflammation.The pathology was mainly inactive in the cases of mild,moderate and severe IM.The Helicobacter pylori (Hp) infection rate was low in mild,moderate and severe IM.The comparison showed that the statistically significant difference was found in the distribution of Hp infection of the IM grade (P<0.05),but the detection rate of Hp infection in mild IM cases was higher.The liver,stomach,kidney and spleen were found to be the main disease position.Qi deficiency,yin deficiency,qi stagnation,phlegm,blood deficiency,yang deficiency,dampness,heat,and blood stasis were found to be the main nature of disease.Conclusion Glandular atrophy gradually worsens with the degree of IM.The amount of Hp bacteria in the IM area decrease with the degree of IM,suggesting that endoscopic detection of Hp bacteria should avoid IM area.Disease positions are mainly located in liver,stomach,spleen,and kidney.Natures of disease are mainly distributed in qi deficiency,yin deficiency,qi stagnation,phlegm,blood deficiency,yang deficiency,dampness,heat,blood stasis,etc.
2020 Vol. 27 (36): 151-154 [Abstract] ( 27 ) HTML (1 KB)  PDF  (0 KB)  ( 11 )
155 Effect of Wenjing Yibing method in the treatment of decreased ovarian reserve function patients with cold and dampness constitution and its effect on serum follicle-stimulating hormone,luteinizing hormone and estradiol
YOU Jun-wen ；WANG Yan ；JIA Meng-hui ；WANG Xiao-li ；YANG Ying
Objective To investigate the effect of Wenjing Yibing method in the treatment of decreased ovarian reserve function (DOR) patients with cold and dampness constitution and its effect on serum follicle-stimulating hormone(FSH),luteinizing hormone (LH) and estradiol (E2).Methods Sixty DOR patients with cold and dampness constitution admitted to the First People′s Hospital of Yinchuan City,Ningxia Hui Autonomous Region from January 2018 to January 2019 were selected as subjects of this study.They were divided into treatment group and control group by random number table method,with 30 patients in each group.After admission,patients in the control group were given Estradiol Valerate Tablets/Estradiol Cycloprogesterone Tablets for treatment.On the basis of the control group,patients in the treatment group were added with Wenjing Yibing method for treatment.After the treatment,the clinical efficacy of the two groups was compared.The differences in ovarian reserve function (endometrial thickness,mean ovarian diameter [MOD]) and sex hormone (FSH,LH,E2) were compared between the two groups before and after the treatment.The occurrence of adverse reactions during medication was compared between the two groups..Results The total response rate after treatment in the treatment group (83.33%) was higher than that in the control group (60.00%),and the difference was statistically significant (P<0.05).After treatment,the endometrial thickness and MOD levels of patients in the treatment group were higher than those in the control group and before treatment,the differences were statistically significant (P<0.05).After treatment,the FSH and LH levels in the treatment group were lower than those in the control group and before treatment,and the differences were statistically significant (P<0.05).After treatment,the E2 level in the treatment group was higher than that in the control group and before treatment,and the difference was statistically significant (P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups (P>0.05).Conclusion It is safe and effective to treat DOR patients with cold and dampness constitution by using the Wenjing Yibing method,which can improve the ovarian reserve function of patients and regulate the level of sex hormone.
2020 Vol. 27 (36): 155-158 [Abstract] ( 31 ) HTML (1 KB)  PDF  (0 KB)  ( 8 )
159 Application effect of traditional Chinese medicine combined with acupuncture on ovulation induction cycle in intrauterine insemination
WANG Ying ；PAN Li-zhen； CHEN Xian
Objective To investigate the application effect of traditional Chinese medicine combined with acupuncture on ovulation induction cycle in intrauterine insemination.Methods A total of 84 patients with intrauterine insemination(128 ovulation induction cycles in total) admitted to the Reproductive Center of Nanping People′s Hospital from January to December 2018 were selected as the research objects,and were divided into control group (42 cases,62 ovulation induction cycles) and observation group (42 cases,66 ovulation induction cycles) according to the random number table method.The control group was treated with Clomiphene Citrate/Letrozole/injection of Urinary Follicle-Stimulating Hormone + human chorionic gonadotropin (HCG) + intrauterine insemination.On the basis of treatment in the control group,the observation group was added with traditional Chinese medicine combined with acupuncture.The serum luteinizing hormone (LH) and estradiol (E2) values of the two groups were observed on HCG day,and the endometrial typing,endometrial thickness and pregnancy status of the two groups were compared..Results There were no significant differences in serum LH and E2 on HCG day between the two groups (P>0.05).The endometrial type in the observation group was better than that in the control group,and the endometrial thickness was higher than that in the control group,with statistically significant differences (P<0.05).The incidence of luteinized unruptured follicle syndrome in the observation group was lower than that in the control group,the difference was statistically significant (P<0.05).The incidence rates of intrauterine pregnancy,spontaneous abortion and ectopic pregnancy were compared between the two groups,and the differences were not statistically significant (P>0.05).Conclusion Traditional Chinese medicine combined with acupuncture therapy can improve the type and thickness of endometrium,reduce the incidence of luteinized unruptured follicle syndrome,which is worthy of promotion
2020 Vol. 27 (36): 159-162 [Abstract] ( 28 ) HTML (1 KB)  PDF  (0 KB)  ( 11 )
163 Effect of Shengyang Jianghuo Decoction plus or minus on recurrent oral ulcer
LI Jun-fei
Objective To explore the effect of Shengyang Jianghuo Decoction plus or minus on recurrent oral ulcer.Methods From February 2018 to February 2020,70 patients with recurrent oral ulcer diagnosed and treated in the Department of Internal Medicine Outpatient of Putian Prison Hospital in Fujian Province were selected as the research objects.According to the random number table method,the patients were divided into control group (35 cases,treated with Metronidazole) and observation group (35 cases,treated with Shengyang Jianghuo Decoction plus or minus).The treatment effect and recurrence rate of follow-up for 6 months were compared between the two groups..Results The total effective rate of patients in the observation group was higher than that in the control group,and the difference was statistically significant (P<0.05).Follow-up results showed that the recurrence rate in the observation group was lower than that in the control group,and the difference was statistically significant (P<0.05).Conclusion The treatment of recurrent oral ulcer with Shengyang Jianghuo Decoction plus or minus can improve the efficacy of the patients,reduce the recurrence rate,improve the safety,and is worthy of clinical application
2020 Vol. 27 (36): 163-166 [Abstract] ( 28 ) HTML (1 KB)  PDF  (0 KB)  ( 12 )
167 Distribution and drug resistance of pathogenic bacteria in patients with febrile neutropenic hematopathy in Luohu District of Shenzhen City
ZHONG Xiao-zhen； WEI Jie-hong；YANG Ting； CAI Yi-hua；ZHENG Wen-xuan； QIN Gui-zhi；TIAN Qi； HAO Tong-yu
Objective To analyze the distribution and drug resistance of pathogenic bacteria in patients with febrile neutropenic hematopathy in Luohu District of Shenzhen city.Methods The clinical data and drug sensitivity test results of 305 patients with febrile neutropenic hematopathy from June 2017 to December 2019 in Luohu District of Shenzhen City were retrospectively analyzed,and the distribution and drug resistance of pathogens were analyzed..Results Among the 305 cases of blood culture positive specimens,82 non-duplicative pathogenic bacteria were isolated,among which 61 were gram-negative bacteria,accounting for 74.39%,and Escherichia coli was the most,with 31 strains (37.80%).There were 18 gram-positive bacteria,accounting for 21.95%,and Coagulase-negative Staphylococcus was the most,8 strains (9.76%).There were three strains of fungus,accounting for 3.66%.The susceptibility test results showed that the resistance rates of Klebsiella pneumoniae and Escherichia coli to lactamase inhibitors were 40%-90%,but the resistance rates of Escherichia coli and Klebsiella pneumoniae to β lactamase inhibitors complex Piperacillin/Tazobactam were lower,6.00% and 11.00%,respectively.The drug resistance rates of Escherichia coli and Klebsiella pneumoniae to Amikacin were 25.50% and 12.30% respectively.The drug resistance rates of Escherichia coli and Klebsiella pneumoniae to Cefoxitin were 38.00% and 10.00%respectively.Klebsiellapneumoniae and Escherichia coli were highly sensitive to Meropenem and Imipenem.Pseudomonas aeruginosa was also highly sensitive to Meropenem and Imipenem,and the drug resistance rate to Piperacillin/Tazobactam,Cefepime,Aminoglycosides and Quinolones was 12.00%-26.00%.The drug resistance rate of Staphylococcus aureus to Erythromycin,Oxacillin and Penicillin antibacterial drugs was as high as 33.00%-100.00%.Coagulase-negative Staphylococcus had higher drug resistance than Staphylococcus aureus,reaching 44.00%-100.00%.Conclusions Gram negative bacteria are the main pathogens of patients with febrile neutropenic hematopathy in Luohu District of Shenzhen City,and they are highly sensitive to Meropenem and Imipenem.
2020 Vol. 27 (36): 167-170转177 [Abstract] ( 27 ) HTML (1 KB)  PDF  (0 KB)  ( 13 )
171 Changes and significance of serum homocysteine and hypersensitive Creactive protein in patients with hypertension
LI Ying； ZENG Xiu-ping ；XIE Shu-ying
Objective To explore the changes and significance of serum homocysteine and high-sensitivity C-reactive protein in patients with hypertension.Methods A total of 100 patients with hypertension admitted to the Shaoguan Institute of Occupational Disease Control from February 1,2015 to February 10,2016 were selected as the observation group (according to their different degrees of disease,they were divided into mild [30 cases],moderate [30 cases] and severe [40 cases]).In addition,100 healthy subjects were selected as the control group.The levels of serum homocysteine and high-sensitivity C-reactive protein of subjects in two groups were measured,and the levels of subjects in the two groups were analyzed..Results Serum homocysteine and high-sensitivity C-reactive protein levels in the observation group were higher than those in the control group,the differences were statistically significant (P<0.05).Serum homocysteine and high-sensitivity C-reactive protein levels in severe patients were higher than those in mild and moderate patients,serum homocysteine and high-sensitivity C-reactive protein levels in moderate patients were higher than those in mild patients,the differences were statistically significant (P<0.05).Conclusion Serum homocysteine and high-sensitivity C-reactive protein are closely related to the development of hypertension,which can reflect the severity of hypertension,provide a favorable basis for the later treatment of hypertension,and is worthy of promotion and application in clinical.
2020 Vol. 27 (36): 171-173 [Abstract] ( 27 ) HTML (1 KB)  PDF  (0 KB)  ( 9 )
174 Expression and clinical significance of Survivin and p300/CBP related factor in cervical cancer
LI Lei；WANG Qing-qing；XU Yan-hua； ZHANG Jun-tao
Objective To explore the expression of Survivin and p300/CBP-related factor in cervical carcinoma and the relationship between the two factors.Methods A total of 40 patients with cervical carcinoma and 10 patients without cervical carcinoma who were admitted to Dongying District People′s Hospital of Dongying city from February 2016 to February 2020 were selected and were divided into cervical carcinoma group and normal cervical tissue group.The Immunohistochemical SP method was used to detect the expression of Survivin protein and p300/CBP-related factor in cervical tissue,and the expression characteristics and clinical significance of Survivin protein and p300/CBP-related factor were compared and analyzed..Results The positive expression rate of Survivin protein in cervical carcinoma group (72.5%) was higher than that in normal cervical tissue group (0.0%),the difference was highly statistically significant (χ2=17.262,P<0.001).The positive expression rate of Survivin protein gradually increased with the increase of neoplasm stage and pathologic grade (P<0.05) and had no relationship with the age and histological type of the patient(P>0.05).The positive expression rate of p300/CBP-related factor in cervical carcinoma group (40.0%) was lower than that of normal cervical tissue group (80.0%),the difference was statistically significant (χ2=5.128,P=0.024).The positive expression rate of p300/CBP-related factor gradually increased with the increase of neoplasm stage and pathologic grade (P<0.05),and had no relationship with the age and histological type of the patient (P>0.05).The expression of Survivin protein and p300/CBP-related factor in cervical carcinoma was closely related.Conclusion The abnormal high expression of Survivin protein and the low expression of p300/CBP related factor play a role in cervical carcinoma,and are related to the clinical stage and tumor grade of cervical carcinoma,suggesting that the prognosis of cervical carcinoma is poor.There was also a correlation between the two proteins.
2020 Vol. 27 (36): 174-177 [Abstract] ( 31 ) HTML (1 KB)  PDF  (0 KB)  ( 12 )
178
Analysis of factors influencing mental health status of infertile patients
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Analysis of factors influencing mental health status of infertile patients #br#[J]. 中国当代医药, 2020,27(36): 178-182转187')" href="#"> MEN Xiao-liang LI Dan-feng WANG Ruo-ke ZHAO Li-ping▲
Objective To investigate the situation of unhealthy emotions,anxiety and depression in infertile patients and the related factors,so as to provide suggestions for the future treatment.Methods A total of 205 infertile patients from January 2019 to December 2019 in Beijing Daxing District Maternal and Children Health Care Hospital were selected as the research objects.General information questionnaire,symptom self-assessment scale SCL-90,Zong anxiety scale and Zong depression scale were filled in.The data were sorted,quantified and assigned.The negative emotions,depression and anxiety of infertile patients were analyzed by chi square test,the related risk factors of multiple factors were analyzed by Logistic regression,and LR backward stepwise method was selected..Results Among infertile patients,the incidence of bad mood was 24.88%,the incidence of anxiety was 19.02%,and the incidence of depression was 20.00%.Infertility treatment time (β=0.538,OR=1.713,95%CI=1.114-2.634) was a risk factor for bad mood (P<0.05),income (β=-0.334,OR=0.716,95%CI=0.523-0.980) and social support (β=-2.911,OR=0.054,95%CI=0.023-0.130)were protective factors for bad mood (P<0.05); residence (β=0.985,OR=2.678,95%CI=1.189-6.032) and non-pregnancy time (β=1.228,OR=3.415,95%CI=1.834-6.358) were risk factors for anxiety (P<0.05),social support (β=-1.786,OR=0.168,95 %CI=0.074-0.377) was a protective factor for anxiety(P<0.05); treatment cost (β=0.552,OR=1.738,95%CI=1.029-2.933) was a risk factor for depression,education level (β=-0.280,OR=0.756,95%CI=0.543-0.949) and social support (β=-2.949,OR=0.052,95%CI=0.020-0.135) were the protective factors of depression (P<0.05).Conclusion Infertility is a disease related to physiological,psychological and social problems.Patients are prone to have unhealthy emotions,anxiety and depression.Treatment time,residence,time of infertility and treatment cost are the risk factors of the above emotions.Income,cultural level and social support are the protective factors.More social support can better treat infertility.
2020 Vol. 27 (36): 178-182转187 [Abstract] ( 30 ) HTML (1 KB)  PDF  (0 KB)  ( 10 )
183 Survey on the quality of education services for full-time postgraduate students with master of nursing specialist in pediatrics
CHEN Fei ；ZHANG Xue-bing；YANG Chen； DU Yu-lin
Objective To understand the satisfaction of full-time postgraduate students with master of nursing specialist in pediatrics on the quality of education services such as curriculum,clinical practice and tutor guidance.Methods According to the results of literature review and interview,the questionnaire of education service quality satisfaction of full-time postgraduate students with master of nursing specialist in pediatrics was developed.A questionnaire survey was conducted among 17 full-time postgraduate students with master of nursing specialist in pediatrics in Nursing College of Chongqing Medical University..Results The satisfaction degree of full-time postgraduate students with master of nursing specialist in pediatrics to the quality of education service was in the upper middle level.Different grades of full-time postgraduate students with master of nursing specialist in pediatrics had different requirements for the working years of clinical teachers (P<0.05).There was no significant difference in the professional title requirements of clinical teaching teachers among different grades of full-time postgraduate students with master of nursing specialist in pediatrics (P>0.05).There was significant difference in long-term clinical practice among different grades of full-time postgraduate students with master of nursing specialist in pediatrics (P<0.05).Case teaching (82.35%) and discussion learning (76.47%) were the most recognized teaching methods for full-time postgraduate students with master of nursing specialist in pediatrics.The most suitable clinical teaching form was specially assigned teaching (82.35%).The abilities that clinical teaching teachers should possess were scientific research ability (88.24%),clinical practice ability(88.24%) and career guidance ability (70.59%).Conclusion The quality of education for postgraduate students with master of nursing specialist in pediatrics should be improved,and the curriculum,clinical practice and clinical teaching teacher team should be strengthened to lay a solid foundation for the overall development of postgraduate students with master of nursing specialist in pediatrics.
2020 Vol. 27 (36): 183-187 [Abstract] ( 22 ) HTML (1 KB)  PDF  (0 KB)  ( 12 )
188 Changes of perceived social support with depressed outpatients under the full-term management model
ZHENG Yin-jia；YIN Xi-yang
Objective The aim of this study was to investigate the changes of perceived social support ability of outpatients with depression under the full-term management model.Methods From Augest 2017 to December 2018,200 depressed outpatients who were admitted to the Fifth Affiliated Hospital of Guangzhou Medical University were selected as the study objects,they were divided into study group and control group according to the random number table method,each with 100 cases.The full-term management model was used in the study group and the natural follow-up mode was used in the control group.Additionally,Patient Health Questionnaire-9 (PHQ-9) and Perceived Social Support Scale (PSSS) were also integrated into this investigate at before treatment,6 months of treatment and 1 year of treatment..Results After 6 months and 1 year of treatment,the comprehension of social support ability of patients in the study group was higher than that before treatment,the difference was statistically significant (P<0.05).After 6 months and 1 year of treatment,the patients in the study group had higher ability to perceive social support than the control group,and the difference was statistically significant (P<0.05).Furthermore,cross hysteresis analysis showed that perceived social support of patients show the variations for the periods,which could predict the change of PHQ-9 one year later.Conclusion The full-term management measurement might significantly improve outpatient ability of perceived social support; it is worthwhile for psychiatrist to promote in outpatient clinic.
2020 Vol. 27 (36): 188-192转197 [Abstract] ( 24 ) HTML (1 KB)  PDF  (0 KB)  ( 9 )
193 Analysis and measures of prescription intervention in outpatient pharmacy of Bao′an Maternal and Child Health Hospital in Shenzhen City
FANG De-ping
Objective To analyze the situation of prescription intervention in outpatient pharmacy of Bao′an Maternal and Child Health Hospital in Shenzhen City (hereinafter referred to as "our hospital"),and formulate measures to improve the quality of prescription,promote rational drug use and ensure medical safety.Methods From November 2018 to 2019 December,outpatient pharmacists found unreasonable prescriptions and communicated with doctors in advance.At the same time,a total of 429 intervention prescriptions were retained.Retrospective analysis of these prescriptions was conducted.Typical unreasonable prescriptions were analyzed and discussed..Results The unreasonable prescription was avoided by the intervention beforehand.Among them,there were 19 sheets (4.4%) with non-standard prescriptions,378 sheets (88.1%) with inappropriate prescriptions,and 32 sheets (7.5%) with abnormal prescriptions.The biggest problem in the classification of unreasonable prescriptions was 207 sheets (48.25%) with inappropriate usage and dosage,followed by clinical diagnosis and drug inconsistency,abnormal prescription and contraindications.Conclusion There is still unreasonable situation in outpatient prescription of our hospital,corresponding countermeasures should be taken in time to constantly improve and perfect the intervention measures,in order to improve the quality of prescription and rational drug use level,to ensure medical safety.
2020 Vol. 27 (36): 193-197 [Abstract] ( 23 ) HTML (1 KB)  PDF  (0 KB)  ( 12 )
198 Practice of medicine therapy management service for patients with chronic diseases in pharmaceutical service station
YUAN Ling；YANG Qing；LI Shuang ；CAI Ning ；SHEN Wei
Objective To explore the role and practice of setting up pharmaceutical service station in communities to provide medicine therapy management (MTM) service mode for patients with chronic diseases.Methods From March 2017 to March 2018,MTM service was provided for 75 patients with chronic diseases in a community of Suqian City by the clinical pharmacists.The characteristics of medication-related problems were analyzed before service (from March to August 2017).The improvement of medication-related problems and the evaluation on drug therapy effect by patients were compared and analyzed after service (from September 2017 to March 2018)..Results Through the half-year MTM service,the proportion of patients with irrational drug use decreased from 81.3% to 24.0%.Seven categories of medication-related problems results showed that the proportion of unnecessary drug therapy decreased from 30.7% to 6.7%,the proportion of ineffective drug therapy decreased from 18.7% to 4.0%,the proportion of needs for additional drug therapy decreased from 16.0% to 9.3%,the proportion of dosage too low decreased from 20.0% to 8.0%,the proportion of dosage too high dropped from 6.7% to 0.0%,the proportion of adverse drug events (ADE) dropped from 32.0% to 9.3%,and the proportion of low compliance dropped from 61.3% to 28.0%.After service,the score of Morisky scale in patients ([6.8±1.2] points) were higher than that before service ([4.3±0.8] points),the difference was statistically significant (P<0.05).After service,the total effective rate of the evaluation on the drug therapy effect by the patients was 89.3%,which was higher than that before service accounting for 40.0%,and the difference was statistically significant(P<0.05).Conclusion The implementation of MTM services in a community provides a guarantee for the management of medications for patients with chronic diseases,as well as a reference for the transformation of clinical pharmacists′ work model and the practice of home pharmaceutical care.
2020 Vol. 27 (36): 198-201转211 [Abstract] ( 23 ) HTML (1 KB)  PDF  (0 KB)  ( 15 )
202 Practice of standardized management of drugs for clinical trials
CHEN Jie； XIAO Lv ；YANG Wen； LIN Yan-mei ；WANG Li ；LIN Xiao-xiao
According to the Good Clinical Practice of Pharmaceutical Products (hereinafter referred to as "GCP") and combined with the current situation of drug management for clinical trials in People′s Hospital of Pingxiang City (hereinafter referred to as "our hospital"),our hospital has explored and established a more standardized and scientific drug management model for clinical trials,besides,our hospital has revised the drug management system,standardized the operation procedures and plans,equipped with standardized drug management facilities and equipment with dedicated personnel to manage drugs and continuously improved the drug management model through quality control in order to better ensure the safety of subjects and the quality of clinical trials.It has been proved in practice that assigning specific person management of experimental drugs can effectively improve the management level of experimental drugs by relying on the pharmacy of the GCP center and the small drug storehouse of the professional departments.Therefore,it is an inevitable trend for the development of clinical testing institutions to establish a standardized management model for clinical testing drugs.
2020 Vol. 27 (36): 202-204 [Abstract] ( 18 ) HTML (1 KB)  PDF  (0 KB)  ( 10 )
205 Study of rapid response team in obstetric critical operation nursing
CAI Yun-xia
Objective To explore the clinical effect of rapid response team in obstetric critical operation nursing.Methods A total of 156 cases of pregnant women who need emergency cesarean section in Ganzhou People′s Hospital from January 2018 to June 2019 were selected as the research object,according to the time sequence,they were divided into the control group (82 cases from January to September 2018) and the experimental group (74 cases from October 2018 to June 2019).The control group was given operation nursing cooperation according to the routine nursing care of emergency cesarean section,on this basis,the experimental group established a rapid response team with anesthesia department as the first to provide comprehensive medical and nursing cooperation for emergency cesarean section.The related time,neonatal Apgar score and umbilical artery blood pH value were compared between the two groups..Results The time for pregnant women to arrive at operating room,nursing preparation time in operating room,anesthesia completion time,arrival time of neonatal pediatrician,time from skin incision to fetal delivery and decision to delivery interval (DDI) in the experimental group were shorter than those in the control group,and the Apgar score and umbilical artery blood pH value in the experimental group were higher than those of the control group,the differences were statistically significant (P<0.05).Conclusion The establishment of obstetric rapid response team for emergency simulation training and optimization of emergency cooperation process can effectively shorten the DDI of critical obstetric surgery,improve the success rate of rescue,ensure the safety of patients,and effectively improve the prognosis of newborns.
2020 Vol. 27 (36): 205-207 [Abstract] ( 19 ) HTML (1 KB)  PDF  (0 KB)  ( 11 )
208 Countermeasures for the implementation of the core medical system during the COVID-19 prevention period
DING Kai
Since the end of 2019,many cases of pneumonia of unknown cause have been emerged in Wuhan (Hubei,China).It was later confirmed that this unknown pneumonia was caused by a new type of coronavirus infection.It was named as "novel coronavirus pneumonia (NCP)" in China.As early as the National Health Commission released the Novel Coronavirus Pneumonia Diagnosis and Treatment Programme (trial version 4),the disease has been included as a class B infectious disease in the Law of the People′s Republic of China on the Prevention and Treatment of Infectious Diseases,but with prevention and control measures in a class A infectious disease.The sudden COVID-19 epidemic also tests the emergency response capabilities of our country′s and the units′ management system to react to public health emergencies.The core medical system refers to the relevant system and work guidelines that medical institutions and their staff should strictly abide by in their daily diagnosis and treatment activities.It is not only the cornerstone of ensuring medical quality and safety,but also an important rule and system to prevent medical accidents.It includes 18 core items.During the epidemic prevention period,it should be strictly followed,but also be implemented flexibly,especially to the gathering of personnel.To avoid the gathering of personnel to cause the spread of COVID-19 and protect the safety of doctors and patients,it is necessary to make good use of information tools in the information era,such as carrying out online work through OA system,WeChat work groups,QQ work groups,etc.Make sure that all core systems are closely focused on medical safety and epidemic prevention and control.
2020 Vol. 27 (36): 208-211 [Abstract] ( 26 ) HTML (1 KB)  PDF  (0 KB)  ( 10 )
212 Online teaching reform of Chinese pharmacy course based on Chaoxing Xuexitong platform
CHOU An； ZHENG Wen；PENG Dian； OUYANG Hui
The rapid development of information technology has promoted the vigorous development of online teaching,and information-based teaching has become the general trend.In order to prevent the spread of new coronavirus(COVID-19) outbreak and respond to the Ministry of Education′s call for "postponement of school without suspension of learning",the article analyzes the problems in online teaching from three aspects,included curriculum,students,and teaching modes,relying on the Chaoxing Xuexitong platform,the reform of online teaching of Chinese pharmacy was explored from four aspects,included urging pre-lesson preparation,enriching in-class activities,applying PBL teaching methods,and reforming assessment methods.The reforms have improved students′ enthusiasm for learning,effectively supervised learning,and ensured the teaching quality and teaching effect during the epidemic.
2020 Vol. 27 (36): 212-214转218 [Abstract] ( 22 ) HTML (1 KB)  PDF  (0 KB)  ( 15 )
215 Design and implementation of medical physics curriculum ideology and politics
WANG Yi； WANG Yun-hua； WANG Li
Curriculum ideology and politics mainly refers to the combination of all the courses of imparting scientific and cultural knowledge with education.While imparting knowledge,it guides students to establish correct values and world outlook,and build the pattern of all courses curriculum ideology and politics.As a professional basic course in traditional Chinese medicine colleges,medical physics needs to adjust teaching methods and strategies under the concept of curriculum ideology and politics,introduce advanced teaching methods,improve and optimize the teaching evaluation system.It is embodied in the application of teaching methods in the selection of teaching contents and the evaluation of teaching effect in the setting of teaching objectives by combining with the characteristics of disciplines and specialties,gradually infiltrate and strengthen the education function of basic courses,finally achieve the teaching process to strengthen the ideological and political education of students.Taking the teaching practice of medical physics as an example,this article puts forward the concrete implementation plan and the design of the whole teaching process of the courses,which provides a useful reference for the further deepening of the teaching reform.
2020 Vol. 27 (36): 215-218 [Abstract] ( 24 ) HTML (1 KB)  PDF  (0 KB)  ( 12 )
219 Application effect of online and offline mixed teaching in pediatric teaching of traditional Chinese medicine
LIU Hao
Objective To explore the application effect of online and offline mixed teaching in pediatrics teaching of traditional Chinese medicine.Methods A total of 120 cases of 2015 grade students of pediatrics in traditional Chinese medicine in North Sichuan Medical College were selected and divided into the control group and the observation group according to random number table method,60 cases in each group.The control group implemented the conventional teacing mode,and the observation group implemented the online and offline mixed teaching mode.The teaching effect and the self-evaluation recognition of the students of the two groups were compared..Results The scores of learning initiative,mastery of professional knowledge,expression and communication skills,recognition of the teaching model,selfconfidence improvement,and learning efficiency of students in the observation group were than those in the control group,the differences were statistically significant (P＜0.05).The scores of interpersonal skills,learning efficiency,problem solving ability and professional knowledge mastery score of students in the observation group were higher than those in the control group,the differences were statistically significant (P＜0.05).Conclusion The application of online and offline mixed teaching in pediatrics of traditional Chinese medicine has a good effect,which can effectively improve the teaching effect and the recognition of students′ self-evaluation,and provides a new direction for the improvement of teaching quality and the reform of education model.
2020 Vol. 27 (36): 219-221 [Abstract] ( 30 ) HTML (1 KB)  PDF  (0 KB)  ( 11 )
222 Application effect of inhalation feedback combined with personalized tracheal occlusion in post-stroke patients with tracheotomy
LIANG Yi
Objective To explore the application effect of individualized blocking of respiratory feedback in patients with tracheotomy after stroke.Methods A total of 40 patients with tracheotomy after stroke in Liuzhou People′s Hospital,Guangxi Zhuang Autonomous Region from January to December 2019 were selected.According to the different treatment,they were divided into the control group and the observation group,20 cases in each group.The control group used traditional inhalation and mechanical assistance for expectoration+conventional extubation technique,the observation group used personalized blocking technique of respiratory feedback+individualized pipe plugging technology.After extubation，dyspnea,oxygen saturation (SpO2),tracheal cannulation time and pulmonary function were compared between the two groups..Results The total effective rate in the observation group was 95.00%,higher than that of the control group of 50.00%,the difference was statistically significant (P<0.05).The pulmonary function of the two groups before treatment was compared,there was no significant difference (P>0.05).The forced expiratory volume(FEV1) in the first second and the percentage of FEV1 in forced vital capacity (FVC) (FEV1/FVC) in the observation group were higher than those in the control group,the differences were statistically significant (P<0.05).There were no significant differences between the two groups before treatment in the maximal inspiratory volume and maximal inspiratory volume (P>0.05),the maximal inspiratory volume and maximal inspiratory volume in the observation group were higher than those in the control group (P<0.05).The non-incidence rate of pulmonary infection in the observation group was 95.00%,higher than that in the control group (65.00%),the difference was statistically significant (P<0.05).Incidence of dyspnea and the incidence of SPO2 were lower than those of control group,the differences were statistically significant (P<0.05).Conclusion Breathing feedback used in post-stroke patients with tracheotomy+individualized pipe plugging technology has a remarkable effect on lung rehabilitation,it can effectively relieve the function of the lungs,shorten the intubation time of tracheotomy patients,to reduce the effect of extubation on inhalation of patients,worthy of clinical application.
2020 Vol. 27 (36): 222-225 [Abstract] ( 26 ) HTML (1 KB)  PDF  (0 KB)  ( 10 )
226 Application effect of continuous nursing model in type 2 diabetes
XIA Jing-ju ；WANG Hai-li
Objective To analyze the application effect of continuous nursing model in type 2 diabetes (T2DM).Methods From January to December 2018,totally 108 patients with T2DM in Liaoning Provincical People′s Hospital were selected,patients were divided into the control group and the observation group using convenient sampling,54 cases in each group.The control group received routine discharge guidance,the observation group received continuous nursing.The quality of life,self-care ability and blood sugar level of the two groups were compared..Results The quality of life scores of the observation group were lower than those of the control group,the differences were statistically significant(P<0.05).The self-care ability scores of the observation group were higher than those of the control group,the differences were statistically significant (P<0.05).The blood glucose levels of the observation group were lower than those of the control group,and the differences were statistically significant (P<0.05).Conclusion The application of continuous nursing mode in patients with T2DM can improve the patients′s quality of life,promote their self-care ability,and reduce blood glucose level.
2020 Vol. 27 (36): 226-228 [Abstract] ( 24 ) HTML (1 KB)  PDF  (0 KB)  ( 14 )
229 Application of predictive preventive nursing in patients with essential hypertension
LU Jia-li
Objective To explore the clinical application value of predictive preventive nursing in patients with essential hypertension.Methods A total of 80 cases with essential hypertension admitted in the Second Affiliated Hospital of Shenyang Medical College from March 2019 to May 2020 were selected and divided into two groups according to random number table method,40 cases in each group.The control group received routine cardiology nursing,the observation group received predictive preventive nursing,and the adverse events of nursing safety were compared between the two groups.Then the satisfaction between the two groups was compared.The hospitalization time and hospitalization expenses in the two groups were compared..Results The total proportion of nursing safety adverse events such as bed falling,falling,scalding and drug misuse in the observation group was lower than that of the control group,the difference was statistically significant (P<0.05).The satisfaction in observation group was better than that in control group,the hospitalization time in the observation group was shorter than that of the control group,the differences were statistically significant (P<0.05).The hospitalization expenses was lower than that of the control group,the difference was statistically significant (P<0.05).Conclusion The implementation of predictive preventive nursing for hospitalized patients in cardiology department can effectively reduce nursing adverse events,improve nursing satisfaction,shorten hospitalization time and reduce medical expenses.
2020 Vol. 27 (36): 229-231 [Abstract] ( 25 ) HTML (1 KB)  PDF  (0 KB)  ( 15 )
232 Application of predictive nursing to pregnant women with hypertension and acute left heart failure after cesarean section
SHEN Xiu-yuan
Objective To explore the application of predictive nursing after cesarean section of pregnancy-induced hypertension with acute left heart failure.Methods A total of 106 patients with pregnancy-induced hypertension and acute left heart failure puerperal cesarean section who were admitted to Shenyang Red Cross Hospital,Liaoning Province from May 2017 to May 2019 were selected and divided control group and observation group according to the method of care,38 cases in each group.The control group was given conventional treatment and nursing,while the observation group was given predictive care on the basis of the control group.After 2 weeks of intervention,the blood pressure,self-anxiety scale (SAS),self-depression scale (SDS) score and total nursing satisfaction of the two groups were compared..Results After intervention,the blood pressure,SAS and SDS scores of the observation group were lower than those of the control group,the differences were statistically significant (P<0.05).The total nursing satisfaction of the observation group was 98.11% (52/53),higher than that of the control group′s 84.91 % (45/53),the difference was statistically significant (P<0.05).Conclusion Predictive nursing can effectively reduce the blood pressure of pregnant women with acute left heart failure and maternal cesarean section,relieve psychological pressure,improve nursing satisfaction,and promote postpartum recovery.
2020 Vol. 27 (36): 232-234 [Abstract] ( 26 ) HTML (1 KB)  PDF  (0 KB)  ( 11 )
235 Effect of individualized nursing intervention based on the concept of rapid rehabilitation surgery on the postoperative recovery and time effect index of patients undergoing laparoscopic assisted total gastrectomy
DUAN Xiao-dan
 Objective To analyze the effect of individualized nursing intervention based on the concept of rapid re habilitation surgery (FTS) on the recovery and time-effect index of patients after laparoscopic-assisted total gastrectomy.Methods A total of 80 patients who underwent laparoscopic total gastrectomy in Chaoyang Second Hospital,Liaoning Province from November 2017 to November 2019 were selected and divided into two groups by random number table method,40 cases in each group.The control group was given routine nursing intervention,observation group based on the concept of FTS to implement personalized nursing intervention,postoperative recovery and time-effect indicators were compared in the two group..Results The first anal exhaust time,bowel sound recovery time,the first defecation time,the first time to get out of bed,eating time,extubation time in the observation group were shorter than those of the control group,the differences were statistically significant (P<0.05).The time of hospitalization in the observation group was shorter than that in the control group,and the cost of hospitalization was lower than that in the control group,the differences were statistically significant (P<0.05).The total incidence rate of the observation group was 5.00%,and that of the control group was 20.00%,the total incidence rate of the observation group was lower than that of the control group,the difference was statistically significant (P<0.05).Conclusion The individualized nursing intervention of the concept of FTS has positive influence on the recovery and time-effect index of patients after laparoscopic-assisted total gastrectomy.
2020 Vol. 27 (36): 235-237 [Abstract] ( 25 ) HTML (1 KB)  PDF  (0 KB)  ( 19 )
238 Effect of crisis management-based nursing intervention on function and psychological status of patients undergoing anorectal surgery
GUO Jin-yu
Objective To analyze the effect of crisis management-based nursing intervention on function and psychological status of patients undergoing anorectal surgery.Methods A total of 106 patients with anorectal surgery treated in Shenyang Anorectal Hospital from January to December 2019 were selected as the subjects,which were divided into control group and observation group according to random number table method,53 cases in each group.Among them,the control group carried out routine nursing,and the observation group carried out nursing intervention based on crisis management,and the nursing effect of the two groups was compared..Results The self-rating depression scale (SDS),self-rating anxiety scale (SAS) scores in the observation group were lower than those in the control group,the differences were statistically significant (P<0.05).The visual analogue score (VAS) scores at 6,12 h after operation in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).Both groups had local edema,urinary retention,infection and other complications,but the total incidence of complications in the observation group was 7.55%,which was lower than that in the control group of 26.42%,the difference was statistically significant (P<0.05).In the observation group,the total satisfaction rate was 100.00%,which was higher than that in the control group of 83.02%,the difference was statistically significant (P<0.05).Conclusion Nursing intervention based on crisis management can improve the anxiety and depression status of patients,reduce the degree of postoperative pain,reduce the incidence of postoperative complications,improve the satisfaction of patients with nursing,and has strong practicability,which can be widely recommended for clinical application.
2020 Vol. 27 (36): 238-240转244 [Abstract] ( 22 ) HTML (1 KB)  PDF  (0 KB)  ( 12 )
241 Effect of evidence-based nursing in children with asthma nebulization inhalation and its influence on children′s respiratory function and family satisfaction
LI Lin-hua；CUI Ni
Objective To provide evidence-based nursing for children with asthma inhalation therapy for children with asthma,and to analyze the nursing effect,the improvement of respiratory function and the satisfaction of family members.Methods A total of 102 pediatric asthma children treated by atomization inhalation in Dalian Children′s Hospital Affiliated to Dalian Medical University from September 2018 to August 2019 were selected as the research objects,and divided into A and B groups according to the random digital table method,51 cases in each group.Group A was given routine basic nursing,on this basis,group B was given evidence-based nursing.The respiratory function and family satisfaction after nursing were compared between the two groups..Results The total effective rate of nursing in group B(94.1%) was higher than that in group A (76.5%),the difference was statistically significant (χ2=6.331,P<0.05).The disappearance time of wheezing,cough disappearance,and chest tightness disappeared in group B patients and respiratory function recovery time were shorter than those in group A,the differences were statistically significant (P<0.05);the forced expiratory volume in one second (FEV1),forced vital capacity (FVC),and FEV1/FVC were higher than those of this group before intervention,the differences were statistically significant (P<0.05); FEV1,FVC,FEV1/FVC of group B after intervention were higher than those in group A,the differences were statistically significant (P<0.05); the nursing total satisfaction of family members in group B (98.0%) was higher than that in group A (84.3%),the difference was statistically significant (χ2=4.387,P<0.05).Conclusion Evidence-based nursing of pediatric asthma patients undergoing nebulized inhalation therapy is very effective,can significantly improve the respiratory function of children,and can increase family satisfaction,which is worthy of vigorous implementation.
2020 Vol. 27 (36): 241-244 [Abstract] ( 20 ) HTML (1 KB)  PDF  (0 KB)  ( 13 )
245 Intervention effect evaluation of delicacy management of hypertension high-risk population in Suzhou rural area under the background of town village integration
LI Yan； LIAN Yan-shu； CHU Xin-chun； HU Xiao-jiang
Objective To explore the intervention effect of delicacy management of hypertension high-risk population in Suzhou rural area under the background of town village integration.Methods A total of 120 cases of hypertension high-risk population who lived in Songling Town,Wujiang District,Suzhou City,Jiangsu Province from January 2016 to June 2017 were randomly selected as the research objects.The awareness rate of health knowledge,prevalence of unhealthy lifestyle and detection rate of abnormal physical examination indexes of high-risk hypertension population were compared and analyzed before the implementation (January 2016 to June 2016) and after the implementation (July 2016 to June 2017) of town village integrated general practice team refined comprehensive intervention..Results After the intervention,the awareness rates of health knowledge of hypertension high-risk population such as "knowing the hazards of passive smoking","knowing the diagnostic criteria of hypertension","knowing the latest blood pressure value","knowing the recommended amount of daily salt","knowing that blood pressure should be measured regularly","knowing the complications of hypertension" and "knowing that the blood pressure was not the lower the better"were higher than those before the intervention,and the differences were statistically significant (P<0.05).After the intervention,the prevalence rates of adverse lifestyle of hypertension high-risk population such as "heavy salt in diet"," heavy oil in diet","eating less vegetables","no fruits or eating less fruits in diet","no grains and beans in diet","being fond of fat meat" and "no physical exercise" were lower than those before the intervention,and the differences were statistically significant (P<0.05).After the intervention,the prevalence rates of adverse lifestyle of hypertension high-risk population such as "long-term smoking","excessive drinking" and "no milk and its products",showed no statistically significant differences (P>0.05).After intervention,the detection rates of abnormal physical examination indicators of hypertension high-risk population such as diastolic blood pressure ≥80 mmHg,male waist circumference≥90 cm,female waist circumference ≥85 cm,total cholesterol (TC) ≥5.7 mmol/L,triglyceride (TG) ≥1.71 mmol/L,were all lower than those before intervention,with statistically significant differences (P<0.05).After intervention,there were no statistically significant differences in the detection rates of abnormal physical examination indexes of hypertension high-risk population such as body mass index (BMI) ≥24 kg/m2 and systolic blood pressure ≥120 mmHg compared with those before intervention (P>0.05).Conclusion The implementation of town village integrated general practice team delicacy comprehensive intervention,can significantly improve the awareness rate of hypertension health knowledge of rural hypertension high-risk population,also can reduce the prevalence of unhealthy lifestyle and abnormal physical examination index detection rate.It obtains a satisfactory application effect and deserves further promotion.
2020 Vol. 27 (36): 245-249 [Abstract] ( 25 ) HTML (1 KB)  PDF  (0 KB)  ( 11 )
250 Discussion on operation management and benefit maximization of ＂one hospital,two districts＂ in governmental hospital
LI Lian-jun； GONG Xiao-qi； LI Yu-hao； FU Ling
With the deepening of the new medical reform,the mode of ＂one hospital,two districts＂ came into being.Choosing the optimal management mode to maximize the social and economic benefits of the hospital has attracted the attention of decision makers and managers of medical and health institutions.This paper takes the ＂one hospital,two districts＂ model of Huizhou Herbalist Doctor Hospital as an example,through the vertical evaluation of its comprehensive benefits,summarizes the operation and management experience,and provides reference for further improving the management level and decision-making ability of ＂one hospital,two districts＂.
2020 Vol. 27 (36): 250-252 [Abstract] ( 19 ) HTML (1 KB)  PDF  (0 KB)  ( 12 )
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