肝癌切除术后行肝动脉化疗栓塞对肝癌患者血清肿瘤标志物的影响

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Abstract Objective To investigate the effect of transcatheter arterial chemoembolization (TACE) after hepatectomy on serum tumor markers in liver cancer patients.Methods A total of 78 patients with primary liver cancer admitted in The First Affiliated Hospital of Clinical Medicine of Guangdong Pharmaceutical University from February 2018 to February 2019 were selected as the research objects,and they were divided into the study group and the control group by the drawing lots method,with 39 cases in each group.The control group was performed with routine hepatectomy.The study group was treated with TACE after hepatectomy.The changes of serum tumor markers such as carcinoembryonic antigen (CEA),alpha-fetoprotein (AFP),alpha-fetoprotein heterojunction (AFP-L3) and glypican-3 (GPC3) before and after treatment were measured and compared between the two groups.And the recurrence rate of the two groups was counted for one year..Results Comparison of four serum tumor markers including CEA,AFP,AFP-L3 and GPC3 between the two groups before treatment,The differences were not statistically significant (P>0.05).The CEA,AFP,AFP-L3 and GPC3 levels of the two groups were lower than those before treatment,the differences were statistically significant (P<0.05).The CEA,AFP,AFP-L3 and GPC3 levels of the study group were lower than those of the control group,the differences were statistically significant (P<0.05).The 1 year recurrence rate in the study group was lower than that in the control group,the difference was statistically significant (P<0.05).Conclusion After hepatectomy,TACE for patients with primary liver cancer can play a more significant role in reducing serum tumor markers,and the recurrence rate of the patients is relatively low,so clinical application has important clinical significance.

Key words： Primary liver tumor Hepatectomy Transcatheter arterial chemoembolization Tumor marker Recurrence

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	LUO Yong-ping
	OU Yi-meng
	YU Jiong-biao

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LUO Yong-ping,OU Yi-meng,YU Jiong-biao. Effect of transcatheter arterial chemoembolization after hepatectomy on serum tumor markers in liver cancer patients[J]. 中国当代医药, 2020, 27(36): 87-89转97.

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https://www.dangdaiyiyao.com/EN/ OR https://www.dangdaiyiyao.com/EN/Y2020/V27/I36/87

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