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| Distribution and drug resistance of pathogenic bacteria in patients with febrile neutropenic hematopathy in Luohu District of Shenzhen City |
| ZHONG Xiao-zhen1，2 WEI Jie-hong1，2 YANG Ting1，2 CAI Yi-hua1，2 ZHENG Wen-xuan1，2 QIN Gui-zhi2 TIAN Qi1，2 HAO Tong-yu1，2 |
1.Department of Medical Laboratory,Shenzhen Luohu District People′s Hospital
2.Medical Laboratory Center,Shenzhen Luohu Hospital Group |
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Abstract Objective To analyze the distribution and drug resistance of pathogenic bacteria in patients with febrile neutropenic hematopathy in Luohu District of Shenzhen city.Methods The clinical data and drug sensitivity test results of 305 patients with febrile neutropenic hematopathy from June 2017 to December 2019 in Luohu District of Shenzhen City were retrospectively analyzed,and the distribution and drug resistance of pathogens were analyzed..Results Among the 305 cases of blood culture positive specimens,82 non-duplicative pathogenic bacteria were isolated,among which 61 were gram-negative bacteria,accounting for 74.39%,and Escherichia coli was the most,with 31 strains (37.80%).There were 18 gram-positive bacteria,accounting for 21.95%,and Coagulase-negative Staphylococcus was the most,8 strains (9.76%).There were three strains of fungus,accounting for 3.66%.The susceptibility test results showed that the resistance rates of Klebsiella pneumoniae and Escherichia coli to lactamase inhibitors were 40%-90%,but the resistance rates of Escherichia coli and Klebsiella pneumoniae to β lactamase inhibitors complex Piperacillin/Tazobactam were lower,6.00% and 11.00%,respectively.The drug resistance rates of Escherichia coli and Klebsiella pneumoniae to Amikacin were 25.50% and 12.30% respectively.The drug resistance rates of Escherichia coli and Klebsiella pneumoniae to Cefoxitin were 38.00% and 10.00%respectively.Klebsiellapneumoniae and Escherichia coli were highly sensitive to Meropenem and Imipenem.Pseudomonas aeruginosa was also highly sensitive to Meropenem and Imipenem,and the drug resistance rate to Piperacillin/Tazobactam,Cefepime,Aminoglycosides and Quinolones was 12.00%-26.00%.The drug resistance rate of Staphylococcus aureus to Erythromycin,Oxacillin and Penicillin antibacterial drugs was as high as 33.00%-100.00%.Coagulase-negative Staphylococcus had higher drug resistance than Staphylococcus aureus,reaching 44.00%-100.00%.Conclusions Gram negative bacteria are the main pathogens of patients with febrile neutropenic hematopathy in Luohu District of Shenzhen City,and they are highly sensitive to Meropenem and Imipenem.
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