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2020 Vol. 27, No. 31 Published: 2020-11-09

	4	Application of non-target and target metabolomics techniques in the screening of serum markers for the diagnosis of lung cancer
		ZHENG Wei-liang；YU Jiang-qing；DU Fen；XIE Bao-gang；HE Xiang-yuan3
		Objective To explore the application value of non-target and target metabolomics technology in the screening of serum markers in lung cancer diagnosis.Methods Based on 1HNMR metabolomics,47 cases of post-operative lung cancer tissues and their corresponding normal lung tissue samples from the First Affiliated Hospital of Nanchang University and Jingdezheng NO.1 People′s Hospital were determined to identify their metabolites and obtain the differential metabolites related to the diagnosis of lung cancer from July 2017 to December 2018.The quantitative analysis of related metabolites in serum of 143 lung cancer patients and 99 healthy control group was carried out by ultra performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS).The excellent metabolite combinations for lung cancer diagnosis were screened based on Logistic regression analysis and receiver operating characteristic curve.Results 1HNMR metabolomics analysis showed that lipids,lactic acid and betaine were differentially metabolites related to lung cancer tissues and normal tissues,suggesting that methylation-related metabolites might be related to the diagnosis of lung cancer.The results of UPLC-MS/MS quantitative analysis showed that the serum samples of lung cancer andhealthy group had significant statistical differences in cystathionine,carnitine,acetyl carnitine,xanthylinucleic acid,guanosine,guanine,inosine,creatinine,uridine,choline,adenine,dimethyl-glycine,adenosine and uric acid (P＜0.05).The combined area under the curve of cystathionine,guanosine,uric acid and adenine was 0.993,with high sensitivity and specificity (＞85%).Conclusion The combination of non-target and target metabolomics techniques to determine serum adenine,guanosine,uric acid and cystathionine can be used as a potential serum marker for the diagnosis of lung cancer and is worthy of further clinical confirmation and research.
		2020 Vol. 27 (31): 4-8 [Abstract] ( 32 ) HTML (44 KB) PDF (0 KB) ( 13 )

	9	Experimental study of injection platelet-rich fibrin combined with BMSCs on sciatic nerve injury
		YE Fang；WANG Yan-sheng；YU Ning；XU Hui
		Objective To investigate the application effect of injection platelet-rich fibrin combined with Bone marrow mesenchymal stem cells (BMSCs) on sciatic nerve injury.Methods A total of 6 cases 10-day-old SD suckling rats of either sex were cultured and purify BMSCs group for later use,and 24 2-month-old SD rats half male and half female of either sex were selected,and 24 cases 2-month-old SD rats were randomly divided into observation group and control group,each had 12 cases.A rat sciatic nerve injury model was established by modified extrusion injury method.BMSCs suspension 250 μl and autologous platelet-rich fibrin 250 μl were locally injected into the observation group and the injury site,and 500 μl of normal saline was locally injected into the control group.Then the changes of sciatic nerve function index before and after intervention were compared between the two groups.The result of transmission electron microscope images of sciatic nerve axons of rats were analyzed 14 days after treatment of the two groups.The changes of wet quality of gastrocnemius muscle in 14 days after intervention in the two groups were counted.Results Before treatment,there was no significant difference in sciatic nerve function index between the two groups (P＞0.05);after treatment,the sciatic nerve function index of the observation group was lower than that before treatment and of the control group,the difference was statistically significant (P＜0.05); after 14 days of treatment,the rat sciatic nerve transmission electron microscope showed that the ratio of myelin axons in the observation group was higher than that in the control group,the wet mass of the gastrocnemius in the observation group was higher than that in the control group,and the recovery rate of the wet mass of the gastrocnemius in the observation group was higher than that in the control group,the differences were statistically significant (P＜0.05).Conclusion For sciatic nerve injury rats,the use of autologous injection platelet-rich fibrin combined with BMSCs for treatment can effectively improve sciatic nerve function,so it can promote nerve repair and improve smooth muscle and vascular regeneration.
		2020 Vol. 27 (31): 9-12 [Abstract] ( 34 ) HTML (36 KB) PDF (0 KB) ( 16 )

	13	Expression and biological behavior of Rac1 protein in colorectal cancer: a Meta-analysis
		XU Juan；XIE Min-juan；XU Shi-zhang
		[Abstract]Objective To systematically evaluate the expression and biological behavior of Rac1 protein in colorectal cancer (CRC).Methods Literatures were searched related to Rac1 protein and CRC from the databases of China National Knowledge Infrastructure (CNKI),Wanfang,China Biology Medicine disc (CBM),PubMed,Google Scholar.The retrieval time was from January 1990 to November 2019.Meta-analysis was performed using Review Manager 5.3.Results Finally,six literatures including 1011 cases were included.The expression rate of Rac1 protein in CRC was higher than that in normal tissues,with statistically significant difference (OR=79.97,95%CI 4.65-1374.11,P=0.003).The expression rate of Rac1 protein in stage Ⅰand Ⅱof CRC was lower than that in stage Ⅲand Ⅳ,with statistically significant difference (OR=0.26,95%CI 0.10-0.67,P=0.005).The expression rate of Rac1 protein in low differentiated cancer specimens was higher than that in high differentiated cancer specimens,with statistically significant difference(OR=2.51,95%CI 1.55-4.06,P=0.0002).The expression rate of Rac1 protein in CRC with lymph node metastasis was higher than that without lymph node metastasis,with statistically significant difference (OR=2.56,95%CI 1.36-4.82,P=0.004); and the expression rate of Rac1 protein in CRC with distant metastasis was higher than that without distant metastasis group,with statistically significant difference (OR=11.64,95%CI 5.71-23.70,P＜0.000 01).Conclusion Rac1 protein expression is closely related to the occurrence and development,invasion and metastasis,prognosis and other biological behaviors of CRC.
		2020 Vol. 27 (31): 13-16 [Abstract] ( 33 ) HTML (38 KB) PDF (0 KB) ( 13 )

	17	Analysis of environmental factors for storage of solid preparations
		LI Bing CHEN Li-xin
		Objective To understand the storage conditions of solid preparations in hospitals,and to analyze their characteristics so as to strengthen drug quality control.Methods A total of 409 kinds of solid preparations form drugs with the largest number in Liaoning Jinqiu Hospital from January to April 2020 were selected as the research objects.The storage conditions of light,temperature,humidity and sealing degree in the package inserts were counted and recorded,and the storage stability was analyzed combined with the pharmacological effects and dosage form characteristics of the drugs.Results Tablet was the most common form of solid preparation,accounting for 57.95%.Among the humidity conditions,decoction pieces,powder and traditional Chinese medicine pills had the highest humidity requirements,accounting for 100.00%,83.33% and 54.55% of the dosage forms respectively.In the condition of temperature,all the drugs in three solid preparations,inhaled powder,freeze-dried powder and powder had the limitation of temperature.In the light condition,the lyophilized powder preparation had the highest requirement for light,accounting for 75.00% of the dosage form.All the varieties in broken wall decoction pieces,granules,pills and powder had the limitation of sealing.According to the classification of pharmacological actions,the proportion of anti-tumor,vitamins and minerals and the anti-microbial drugs limitation of light,temperature,humidity and density of were the highest,accounting for 16.67%,15.38% and 10.71% of the pharmacological actions,respectively.Conclusion Combining with the characteristics of solid dosage form and pharmacological action,improving the drug storage environment,perfecting the drug storage system,and strengthening the drug quality control management can ensure the drug quality.
		2020 Vol. 27 (31): 17-20-25 [Abstract] ( 29 ) HTML (41 KB) PDF (0 KB) ( 14 )

	21	Research progress on the relationship between lipoprotein-associated phospholipase A2 and atherosclerosis and coronary heart disease
		LI Zhi-Hong1,2；SHEN Qiang1，2▲
		Cardiovascular disease (CVD) has become a serious disease endangering human health,and its morbidity and mortality remain high in China,which brings great pain and burden to people′s lives.In recent years,with the indepth study of atherosclerosis and coronary heart disease,lipoprotein-associated phospholipase A2 (Lp-PLA2),as a newly discovered inflammatory marker,has attracted more and more attention due to its involvement in its occurrence and development,and now it is considered to be a variable predictor of CVD risk.After collating the related literature in recent years,this paper mainly reviews the structural characteristics and influencing factors of Lp-PLA2 and its relationship with atherosclerosis and coronary heart disease.
		2020 Vol. 27 (31): 21-25 [Abstract] ( 31 ) HTML (42 KB) PDF (0 KB) ( 11 )

	26	Research progress on dysmenorrhea status and its influencing factors in female college students
		WANG Kai-li；ZHANG Min；ZENG Xiao-hong；YU Wen-qing；SU Wen-yu；FU Yang-yang▲
		Research reports that female college students have extensive dysmenorrhea.Dysmenorrhea will have a great impact on their daily life and study,and will lead to them experience symptoms such as lack of energy and concentration.It is of great significance to understand the harm of dysmenorrhea and to study the factors that cause dysmenorrhea.A large number of documents show that the main factors that cause dysmenorrhea are physical and psychological aspects.This article will synthesize various reasons,integrate the dysmenorrhea status and influencing factors of female college students,and put forward our own views.
		2020 Vol. 27 (31): 26-29 [Abstract] ( 33 ) HTML (43 KB) PDF (0 KB) ( 13 )

	30	Application of 3D printing model in surgery for high-energy intra-articular fracture
		LI Chang-jie；MAO Wen-jing；ZHOU Chong-gang；YU Xue-wen；LYU Sui-ben
		Objective To explore the effect of 3D printing model on the treatment of patients with high energy intra-articular fracture surgery.Methods A total of 40 patients with high-energy intra-articular fracture who were treated in our hospital from December 2017 to December 2018 were selected as the research subjects.All the patients were divided into control group and observation group according to the odd and even numbers of beds on admission,20 cases in each group.The control group underwent routine open reduction and special-shaped plate internal fixation,and 3D printing technology was used to print high-energy joint fracture model in observation group before surgery,and then the individualized surgical plan was designed based on the model.The clinical surgical indexes were compared between the two groups.The rehabilitation and ankle joint function were compared between the two groups after 12 months of postoperative follow-up,and the incidence of complications was recorded.Results The operation time of the observation group was shorter than that of the control group,and the intraoperative blood loss was less than that of the control group,the differences were statistically significant (P＜0.05) As time went by,the postoperative swelling degree and visual analogue scale (VAS) score of the two selected groups became lower and lower,and the weight bearing situation became better and better; After surgery for 1,3,6 and 12 months,the swelling degree and VAS score of observation group were lower than those of the control group,and the weight-bearing score was higher than that of the control group,the differences were statistically significant (P＜0.05).As time went by,the joint function scores of the two groups of candidates were getting higher and higher.The scores of joint function in observation group were higher than those of the control group after surgery for 1,3,6 and 12 months,the differences were statistically significant (P＜0.05).There was no statistically significant difference between the two groups in the total incidence of complications (P＞0.05).Conclusion 3D printing model in treatment of patients with high-energy intra-articular fracture surgery can shorten operation time,reduce intraoperative bleeding volume,promote rehabilitation,enhance recovery of joint function,and not increase complications.
		2020 Vol. 27 (31): 30-33 [Abstract] ( 30 ) HTML (35 KB) PDF (0 KB) ( 14 )

	34	Therapeutic effect of central venous catheter closed thoracic drainage in the treatment of septal tuberculous pleurisy
		LIAO Xin-hui；LIU Xiao-ni；ZHONG Bin；ZHANG Gui-juan；LIN Hai；LAI Qing-wen
		Objective To investigate the clinical efficacy of central venous catheter closed thoracic drainage in the treatment of septal tuberculous pleurisy.Methods A total of 60 patients with septal tuberculous pleurisy admitted to our hospital from January to June 2019 were selected as the reaseach subjects.They were divided into the control group and the treatment group according to the order of admission,with 30 cases in each group.Both groups were treated with conventional anti-tuberculosis regimen.On this basis,the control group was treated with thoracentesis and the treatment group was treated with central venous catheter closed thoracic drainage.The clinical efficacy,disappearance time of effusion,length of hospital stay,incidence of adverse reactions and pleural thickening rate were compared between the two groups.Results The total effective rate of the treatment group (93.33%) was higher than that of the control group (73.33%),and the difference was statistically significant (P＜0.05).The disappearance time of effusion and length of hospital stay of the treatment group ([8.16±2.21]d,[9.33±2.34]d) were shorter than those of the control group([11.43±2.60]d,[13.28±2.85]d),and the differences were statistically significant (P＜0.05).During the treatment,the incidence of adverse reactions and pleural thickening rate in the treatment group (6.67%,6.67%) were lower than those in the control group (26.67%,30.00%),and the differences were statistically significant (P＜0.05).Conclusion Central venous catheter closed thoracic drainage is effective in the treatment of septal tuberculous pleurisy with fewer adverse reactions,can promote the disappearance time of effusion,prevent pleural thickening,and shorten the length hospital stay.
		2020 Vol. 27 (31): 34-36 [Abstract] ( 34 ) HTML (34 KB) PDF (0 KB) ( 12 )

	37	Effect of single-hole thoracoscopic pulmonary bullectomy treating patients with spontaneous pneumothorax
		HU WEI
		Objective To explore the effect of single-hole thoracoscopic pulmonary bullectomy treating patients with spontaneous pneumothorax.Methods Sixty patients with spontaneous pneumothorax who received treatment in our hospital from November 2017 to November 2018 were selected as the objects of study.According to random number table method,they were divided into control group and observation group,30 cases in each group.The patients in the control group were treated with traditional thoracoscopic surgery,and the observation group was treated with single-hole thoracoscopic bullae resection.The visual analogue scale (VAS),comprehensive quality of life questionnaire-74 (QOL-74),postoperative hospital stay omplications,recurrence of pneumothorax,the related indexes such as the number of analgesics used after operation were compared.Results The VAS score,pneumothorax recurrence rate,the number of analgesics used after surgery,and the incidence of complications in the observation group were lower than those of the control group,and the GQOL-74 score was higher than that of the control group; the hospital stay of the observation group was shorter than that of the control group,the differences were statistically significant (P＜0.05).Conclusion Treatment of patients with spontaneous pneumothorax by single-hole thoracoscopic pulmonary bullectomy can relieve postoperative incision pain and improve the quality of life in patients with unilateral spontaneous pneumothorax.It is worthy of clinical reference.
		2020 Vol. 27 (31): 37-39 [Abstract] ( 31 ) HTML (32 KB) PDF (0 KB) ( 12 )

	40	Application of Rifampin drug resistant real-time fluoresceknt quantitative nucleic acid amplification in clinical pathway of pulmonary tuberculosis
		TONG Bo-shan
		Objective To analyze the application effect of Rifampicin drug resistant real-time fluorescent quantitative nucleic acid amplification (Xpert Mtb/RIF) in clinical pathway of pulmonary tuberculosis.Methods A total of 80 patients with pulmonary tuberculosis admitted to our hospital from July 2018 to July 2019 were selected as the subjects of study,and they were divided into two groups by random number table method,40 cases in each group.The control group was treated with the routine method of tuberculosis directly without Xpert Mtb/RIF,the experimental group was treated according to the results of Xpert Mtb/RIF test.The length of stay and the cost of diagnosis and treatment were compared between the two groups.The incidence of gastrointestinal reactions was compared between the two groups.The satisfaction of the two groups was compared.Results The length of stay in hospital in the experimental group was shorter than that in the control group,and the cost of diagnosis and treatment in the experimental group was lower than that in the control group,and the differences were statistically significant (P＜0.05).The total incidence of gastrointestinal reactions in the experimental group was lower than that in the control group,and the difference was statistically significant (P＜0.05).The treatment total satisfaction of the experimental group was higher than that of the control group,and the difference was statistically significant (P＜0.05).Conclusion Treatment of pulmonary tuberculosis after tested by Xpert Mtb/RIF can effectively shorter the number of days in hospital and reduce the cost of diagnosis and treatment,reduce the incidence of gastrointestinal reactions,and improve the treatment satisfaction of patients.Rifampin drug resistant real-time Xpert Mtb/RIF has the value of promotion in the clinical treatment of tuberculosis patients.
		2020 Vol. 27 (31): 40-42 [Abstract] ( 34 ) HTML (31 KB) PDF (0 KB) ( 16 )

	43	Study of urinary tract pathogens and drug sensitivity in patients with ureteral calculi obstruction
		ZHANG Fu-yuan
		Objective To explore urinary tract pathogens and drug sensitivity in patients with ureteral calculi obstruction.Methods From March to November 2017,79 patients with ureteral calculi obstruction in our hospital were selected as the research subjects.The upper and lower urine samples of the patients were collected for bacterial culture and drug sensitivity analysis.The distribution of urinary tract pathogens and drug sensitivity were analyzed.Results A total of 46 pathogenic bacteria,including 11 Gram-positive bacteria and 35 Gram-negative bacteria were isolated and detected in the upper urine sample of the patient.A total of 88 pathogenic bacteria including 28 Gram-positive bacteria were isolated and detected in the lower urine sample.The main Gram-positive bacteria had the highest sensitivity to Penicillin,and the main Gram-negative bacteria had the highest sensitivity to Imipenem and Amikacin.Conclusion The main pathogenic bacteria in the urinary tract of patients with ureteral stone obstruction are Gram-negative ones,which have the highest sensitivity to Imipenem and Amikacin.Therapeutic effects of Imipenem and Amikacin for ureteral stone obstruction are relatively favorable.
		2020 Vol. 27 (31): 43-45-49 [Abstract] ( 32 ) HTML (31 KB) PDF (0 KB) ( 13 )

	46	Efficacy and safety observation of Tanreqing Injection combined with antibiotic therapy in the treatment of stroke patients with pulmonary infection
		HAN Xue SHEN Feng-juan
		Objective To investigate the clinical effect and safety of Tanreqing Injection combined with antibiotic therapy in the treatment of stroke patients with pulmonary infection.Methods A total of 90 stroke patients with pulmonary infection who treated in our hospital from January to November 2019 were selected as the research objects and divided into the control group and the experimental group according to random number table method,with 45 cases in each group.The control group achieved antibiotic therapy,while the experimental group achieved Tanreqing Injection combined with antibiotic therapy.The general data of patients,curative effect,adverse reactions,symptom and sign improvements were compared.Results There were no statistically significant differences in occurrences of longterm bedridden conditions,gastroesophageal reflux,cough reflex and swallowing dysfunction between the two groups before treatment (P＞0.05).The total effective rate in the experimental group (97.78%) was higher than that of the control group (84.44%),and the difference was statistically significant (P＜0.05).The total adverse reactions rate in the experimental group (4.44%) was lower than that of the control group (20.00%),and the difference was statistically significant (P＜0.05).The symptom and sign recovery time in the experimental group were shorter than those of the control group,and the differences were statistically significant (P＜0.05).Conclusion The antibiotic therapy combined with Tanreqing Injection can reduce the clinical symptoms and signs,and have less adverse reactions,can improve the life quality significantly.It is worthy of clinical promotion and application.
		2020 Vol. 27 (31): 46-49 [Abstract] ( 30 ) HTML (36 KB) PDF (0 KB) ( 13 )

	50	Application of positive end-expiratory pressure volume test in preoperative volume assessment of patients undergoing off-pump coronary artery bypass grafting
		CHEN Ming;SUN Tong
		Objective To explore the clinical application value of positive end-expiratory pressure (PEEP) volume test in preoperative volume assessment of patients undergoing off-pump coronary artery bypass grafting (OPCABG).Methods A total of 80 cases with OPCABG treated in our hospital from May 2018 to January 2020 were selected and divided into two groups according to random number table method,40 cases in each group.The observation group underwent PEEP volume test combined with semi-horizontal passive straight leg elevation test.The control group underwent passive straight leg elevation test in semi-horizontal position only.Then the changes of invasive arterial pressure indexes were compared.The continuous cardiac output indexes by pulse profile were compared.The dim sum output at different times in the rehydration test was analyzed.Results Systolic blood pressure and diastolic blood pressure in the observation group were higher than those of the control group (P＜0.05),heart rate was lower than that of the control group (P＜0.05),peripheral vascular resistance index and cardiac circulation efficiency were lower than those of the control group(P＜0.05),maximum pressure gradient and cardiac output level were higher than those of the control group,the differences were statistically significant (P＜0.05).Conclusion For patients OPCABG,PEEP volume test combined with semi-horizontal passive straight leg elevation test can improve arterial blood pressure and cardiac function,so it can improve the volume responsiveness.
		2020 Vol. 27 (31): 50-52 [Abstract] ( 33 ) HTML (33 KB) PDF (0 KB) ( 12 )

	53	Clinical effect of Entecavir combined with Diammonium Glycyrrhizinate in the treatment of chronic hepatitis B
		HUANG Xiu-huo;LUO Xian-xin;CHEN Xing
		Objective To observe the effect of Entecavir combined with Diammonium Glycyrrhizinate in the treatment of chronic hepatitis B.Methods From January 2017 to January 2019，a total of 80 cases chronic hepatitis B in our hospital were selected.They were divided into observation group (n=40) and control group (n=40) according to the random number table method.The control group was treated with Diammonium Glycyrrhizinate Enteric Coated Capsules,and the observation group was treated with Entecavir Tablets combined with Diammonium Glycyrrhizinate Enteric Coated Capsules.The liver function indexes before and after treatment and total effective rate were compared between the two groups.Results There were no significant differences in aspartate aminotransferase (AST) and alanine aminotransferase （ALT) between the two groups before treatment (P＞0.05); after treatment,AST and ALT in the observation group were lower those in the control group,the differences were statistically significant (P＜0.05); the ALT normalization rate,HBV-DNA negative conversion rate,HBeAg negative conversion rate and HBeAg/anti HBe conversion rate of the observation group were 92.5%,95.0%,67.5,27.5% respectively,higher than those of the control group of 72.5%,80.0%,45.0%,7.5%,the differences were statistically significant (P＜0.05).Conclusion Entecavir combined with Diammonium Glycyrrhizinate in the treatment of chronic hepatitis B can improve the liver function of the patients significantly,with reliable effect,and can be popularized.
		2020 Vol. 27 (31): 53-55 [Abstract] ( 44 ) HTML (30 KB) PDF (0 KB) ( 11 )

	56	Clinical effect of Omeprazole in the treatment of peptic ulcer accompanied by chronic gastritis
		LIANG He;HE Jin-yun
		Objective To explore the clinical effect of Omeprazole in the treatment of peptic ulcer with chronic gastritis.Methods A total of 200 patients with peptic ulcer associated with chronic gastritis in our hospital from October 2017 to October 2019 were selected.They were divided into two groups by random number table method,and all patients were given basic medicationand,the control group was treated with Ranitidine,the observation group was treated with Omeprazole.The clinical symptoms recovery time,adverse reaction,total treatment efficiency and ulcer healing rate were compared between the two groups.Results After treatment,the recovery time of abdominal pain,belching,acid reflux,nemia,nausea and vomiting in the observation group was shorter than that in the control group; the total incidence rate of adverse reactions in the observation group was lower than that in the control group; the total efficiency of the observation group was 98.00%,higher than that in the control group of 77.00%,the ulcer healing rate of the observation group was 82.00%,which was higher than that of the control group of 62.00%,the differences were statistically significant (P＜0.05).Conclusion The use of Omeprazole in patients with peptic ulcer accompanied by chronic gastritis can effectively shorten the recovery time of clinical symptoms,reduce the rate of adverse reactions,and improve the treatment efficiency and ulcer healing rate.It has achieved good clinical results and is suitable for clinical use.
		2020 Vol. 27 (31): 56-58 [Abstract] ( 36 ) HTML (32 KB) PDF (0 KB) ( 11 )

	59	Application effect of natural convalescent factors combined with exercise intervention on elderly patients with hypertension
		LIN Zhi-qiang;LIN Jia-na;LIN Zhi-wen
		Objective To explore the application effect of natural convalescent factors combined with exercise intervention in elderly patients with hypertension.Methods From January 2018 to December 2019,100 elderly patients with hypertension admitted to Xiamen Special Service Convalescent Center of PLA Army were selected as the research objects,and divided into control group (n=50) and experimental group (n=50) according to the random envelope method.The control group was given general nursing method,and the experimental group was given natural convalescent factors combined with exercise intervention.The therapeutic effects of the two groups were compared,including blood pressure index,emotional index and nursing satisfaction.Results The systolic and diastolic blood pressure of the experimental group was lower than that of the control group,the scores of self-rating anxiety scale (SAS) and self-rating depression scale (SDS) were lower than those of the control group,and the total satisfaction of clinical nursing was higher than that of the control group,the differences were statistically significant (P＜0.05).Conclusion The increase of natural convalescent factors combined with exercise intervention in elderly patients with hypertension can better control blood pressure level,better adjust negative emotions,and improve the overall satisfaction of clinical nursing.
		2020 Vol. 27 (31): 59-61 [Abstract] ( 32 ) HTML (32 KB) PDF (0 KB) ( 16 )

	62	The influence of modular intervention on the rehabilitation effect of inpatients with schizophrenia
		CHEN Na
		Objective To explore the influence of modular intervention on the rehabilitation effect of inpatients with schizophrenia.Methods A total of 100 patients with schizophrenia admitted to the Fifth People′s Hospital of Jiujiang City from January to October 2019 were registered and numbered according to the admission sequence and divided into the study group and the control group by simple random sampling method,with 50 cases in each group.The control group achieved routine management mode,while the study group was divided into positive symptom module group and negative symptom module group and each module was intervened according to its main problems.Activities of daily living (ADL),simple quality of life (SF-36) scales were used as evaluation tool.The ADL scores,the SF-36 scores before and after intervention and total nursing satisfaction were compared between the two groups.Results There were no statistically significant differences in the ADL scores and the SF-36 scores of the two groups before intervention (P＞0.05).After intervention,the ADL scores of the two groups were lower than those before intervention,the SF-36 scores were higher than those before intervention,and the differences were statistically significant (P＜0.05).After intervention,the ADL score of the study group was lower than that of the control group,the SF-36 score was higher than that of the control group,and the differences were statistically significant (P＜0.05).The total nursing satisfaction of the study group (94.0%) was higher than that of the control group (68.0%),and the difference was statistically significant (P＜0.05).Conclusion The modular intervention on the rehabilitation of inpatients with schizophrenia can establish an effective rehabilitation intervention mechanism,improve the quality of life and provide basis for the diversified development of psychiatric nursing.
		2020 Vol. 27 (31): 62-64-68 [Abstract] ( 36 ) HTML (33 KB) PDF (0 KB) ( 15 )

	65	Analysis of risk factors of multi-organ failure after severe craniocerebral injury
		WANG Ke；WEI Liang；WANG Ting；ZHUANG Zhong-wei
		Objective To study the related risk factors of multiple organ failure after severe craniocerebral injury.Methods The clinical data of 80 patients with severe craniocerebral injury admitted to Ji′an Hospital of Shanghai Dongfang Hospital from December 2018 to June 2020 were retrospectively analyzed.The occurrence of multiple organ failure was counted and the related risk factors were analyzed.Results The incidence of multiple organ failure in 80 patients with severe craniocerebral injury was 30.00%,and the mortality rate was 32.50%.Advanced age,GCS score of 3-5 points at admission,extensive brain injury,combined large organ injury,and concurrent infection,combined with chronic underlying diseases,brain herniation,and massive blood transfusion were risk factors for multiple organ failure after severe head injury,the differences were statistically significant (P＜0.05).The number of risk factors were the same as the incidence of multiple organ dysfunction,the number of organ dysfunction and mortality were positively correlated,the differences were statistically significant (P＜0.05).In patients with multiple organ failure,the PCT levels of those with APACHE Ⅱscores of 0-10 points,>10-20 points,and >20 points were (4.30±1.16),(7.81±2.35),(10.91±3.82) μg/L,and the PCT level of the death group were higher than those of the survival group,the differences were statistically significant (P＜0.05).Conclusion A variety of factors can lead to the occurrence of multiple organ failure after severe craniocerebral injury.Serum PCT levels can predict the occurrence,severity and prognosis of multiple organ failure.
		2020 Vol. 27 (31): 65-68 [Abstract] ( 32 ) HTML (1 KB) PDF (0 KB) ( 12 )

	69	Positive electroencephalogram expression and clinical symptom analysis in patients with autoimmune encephalitis
		WU Wei-bo；GUO Li-bing；DU Yun-hua
		Objective To explore the positive expression of electroencephalogram (EEG) and clinical symptoms in patients with autoimmune encephalitis (AE).Methods A total of 31 AE patients admitted to our hospital,Sanjiu Brain Hospital,and Foshan First People′s Hospital from January 2017 to July 2019 were selected as the observation group.Another 30 cases of other brain types during the same period were selected as the control group.According to different anti-nerve cell surface antigen antibodies,the observation group was further divided into the N-methyl-D-aspartate receptor (NMDA) group (n=22) and the limbic encephalitis (LE) group (n=9).The pathological changes of the patients were observed by EEG,and the positive antibody results and the occurrence of clinical symptoms were compared between the NMDA group and the LE group.The EEG performance of the observation group and the control group were compared.Results The positive rate of cerebrospinal fluid antibodies in the NMDA group was 100.00%,the positive rate of seroantibodies was 72.73%,while the positive rates of cerebrospinal fluid antibodies and seroantibodies in the LE group were 100.00% and 66.67% respectively,there were no significant differences in the positive rate of cerebrospinal fluid antibodies and seroantibodies between the two groups (P＞0.05).Abnormal mental behavior,seizures,involuntary movements and fever were the main clinical symptoms in AE patients.The incidence of involuntary movements and fever symptoms in the NMDA group were higher than those in the LE group,and the differences were statistically significant (P＜0.05).There were no significant differences in the incidence of mental and behavioral abnormalities,seizures,myotonia,central hypoventilation,headache,obstinate vomiting,limb numbness,consciousness disorder,autonomic nerve dysfunction and cognitive dysfunction between the two groups (P＞0.05).The similarity of EEG performance in the observation group was lower than that of the control group (P＜0.05).Conclusion The most common clinical symptoms of AE are mental behavior abnormalities and seizures.Compared with other types of encephalitis patients,the similarity of EEG performance of AE patients has certain differences.
		2020 Vol. 27 (31): 69-72 [Abstract] ( 31 ) HTML (35 KB) PDF (0 KB) ( 13 )

	73	Effect of Ziprasidone Mesylate Injection on PANSS-EC,BARS scores and adverse reactions in patients with acute agitation symptoms of schizophrenia
		YUAN Qiang
		Objective To investigate the effect of Ziprasidone Mesyate Injection on excited components of the positive and negative syndrome scale (PANSS-EC),behavioral activity rating scale (BARS) scores and adverse reactions in schizophrenia patients with acute agitation symptoms.Methods The clinical data of 67 schizophrenia patients with acute agitation symptoms who were admitted to our hospital from January 2019 to January 2020 were retrospectively analyzed.All the patients were divided into the control group (34 cases) and the observation group (33 cases) according to different treatment methods.The control group was given Haloperidol Injection,and the observation group was given Ziprasidone Meylate Injection.The clinical efficacy,PANSS-EC,BARS scores before and after treatment and the total incidence of adverse reactions were compared between the two groups.Results The effective rate of the observation group was 90.91%,compared with 88.24% of the control group,the difference was not statistically significant (P＞0.05).The PANSS-EC and BARS scores in two groups after treatment were lower than those before treatment,the differences were statistically significant (P＜0.05).There were no statistical differences in the PANSS-EC and BARS scores between the two groups after treatment (P＞0.05).The total incidence rate of adverse reactions in the observation group (9.09%)was lower than that in the control group,the difference was statistically significant (29.41%) (P＜0.05).Conclusion Ziprasidone Mesilate Injection in the treatment of schizophrenia patients with acute agitation symptoms has better curative effects,whose efficacy is similar to Haloperidol,but it has lower incidence of adverse reactions and better safety.
		2020 Vol. 27 (31): 73-75 [Abstract] ( 32 ) HTML (31 KB) PDF (0 KB) ( 11 )

	76	Clinical effect of Donepezil combined with Olanzapine in the treatment of senile dementia patients with mental and behavioral symptoms
		LIANG Dong-xu
		Objective To investigate the clinical effect of Donepezil combined with Olanzapine in the treatment of senile patients suffering from dementia with mental and behavioral symptoms.Methods A total of 50 senile dementia patients with mental and behavioral symptoms who were admitted to our hospital from May to September in 2019 were randomly selected as the research subjects.According to different treatments,they were divided into the control group and the study group,with 25 cases in each group.In the control group,Donepezil was used,and in the study group,Donepezil + Olanzapine was adopted.The BEHAVE-AD scores before and after treatment,the occurrence of adverse reactions and the Wisconsin card sorting test (WCST) cognitive function score of the two groups were observed and compared.Results There was no statistically significant difference in the BEHAVE-AD scores between the two groups before treatment (P＞0.05).The BEHAVE-AD scores of the two groups after 8 weeks of treatment were lower than those of 4 and 6 weeks after treatment,and the BEHAVE-AD scores of the two groups after 6 weeks of treatment were lower than those of 4 weeks after treatment,with statistical significance (P＜0.05).The BEHAVE-AD scores of the study group at 4,6,8 weeks after treatments were all lower than those of the control group,and the differences were statistically significant (P＜0.05).The total incidence of adverse reactions in the study group after treatment was lower than in the control group,and the difference was statistically significant (P＜0.05).There were no statistically significant differences in the WCST total test trials,random error number,perseverative error number,correct response trials and categories number between the two groups before treatment (P＞0.05).After treatment,the WCST total test trials,random error number,and perseverative error number in the study group were lower than those of the control group,the correct response trials and categories number of the study group after treatment were higher than those of the control group,and the differences were statistically significant (P＜0.05).Conclusion The combined treatment of Donepezil and Olanzapine can improve the senile dementia patients with mental and behavioral symptoms associated and enhance cognitive ability in good safety.
		2020 Vol. 27 (31): 76-78-82 [Abstract] ( 34 ) HTML (34 KB) PDF (0 KB) ( 13 )

	79	Application effect of air pressure wave therapy instrument in elderly patients with lower limbs hemiplegia and cerebral infarction
		WANG Li-yan；ZHANG Xi-guang；ZHAO Chun-yang；LIU Dan；LUO Ya-dan；ZHANG Xiao-dan
		Objective To investigate the application effect of air pressure wave therapy instrument in elderly patients with lower limbs hemiplegia and cerebral infarction.Methods A total of 146 elderly patients with lower limbs hemiplegia and cerebral infarction who treated in the department of neurology of our hospital from January to October 2019 were selected as study objects and divided into the study group and the control group according to the treatment intention of the patients,with 73 cases in each group.The control group received conventional drug treatment and rehabilitation training,while the study group received air pressure wave therapy instrument on the basis of the control group.The stroke scale (NIHSS) scores,the quality of life rating scale (SF-36) scores and lower limb blood flow before treatment and at 10,20,30 d after treatment were compared between the two groups.Results There were no statistically significant differences in NIHSS scores,SF-36 scores and lower limb blood flow in the two groups before treatment (P＞0.05).The NIHSS scores of the two groups at 10,20 and 30 d after treatment were lower than those before treatment,the SF-36 scores were higher than those before treatment,and the differences were statistically significant (P＜0.05).The NIHSS scores of the study group at 10,20 and 30 d after treatment were lower than those of the control group,the SF-36 scores were higher than those of the control group,and the differences were statistically significant (P＜0.05).The leg circumferences of the two groups at 10,20 and 30 d after treatment were less than those before treatment,the velocities of flow in femoral vein were higher than those before treatment,the reflux times were shorter than those before treatment,and the differences were statistically significant (P＜0.05).The leg circumferences of the study group at 10,20 and 30 d after treatment were less than those of the control group,the velocities of flow in femoral vein were higher than those of the control group,the reflux times were shorter than those of the control group,and the differences were statistically significant (P＜0.05).Conclusion Air pressure wave therapy instrument combined with conventional drug therapy can effectively improve the nerve function of the elderly patients with lower limbs hemiplegia and cerebral infarction,and play an important role in accelerating the lower extremity blood flow speed and improving the quality of life,which is worthy of clinical promotion and application.
		2020 Vol. 27 (31): 79-82 [Abstract] ( 38 ) HTML (35 KB) PDF (0 KB) ( 13 )

	83	Clinical application effect of multi-point blood collection with intravenous indwelling needle in glucose tolerance test
		CHU Xiao-fang；BO Yan；LOU Fan；HU Xiao-le
		Objective To explore the clinical application effect of multi-point blood collection with intravenous indwelling needle in glucose tolerance test.Methods From February to October 2019,80 patients who underwent glucose tolerance test in our hospital were selected as the research objects and divided into the control group and the observation group by blind selection and grouping method,with 40 cases in each group.In the control group,routine venipuncture was used for blood collection,while in the observation group,intravenous indwelling needle was used for multi-point blood collection.Blood glucose levels,systolic blood pressure,mental stress and disease severity of the two groups were compared at each time point of blood collection.Results There were no statistically significant differences in the blood glucose levels between the two groups on fasting and 30 minutes,1,2 and 3 hours after taking glucose (P＞0.05).After blood collection,the systolic blood pressure of the observation group at each time point was lower than that of the control group,the difference was statistically significant (P＜0.05).After blood collection,the mental stress and disease severity scores of the observation group were lower than those of the control group,the differences were statistically significant (P＜0.05).Conclusion In patients with glucose tolerance test,the multi-point blood collection method of intravenous indwelling needle is used for blood collection,which can effectively avoid a greater impact on their mental state and blood pressure,and can obtain blood glucose test results similar to conventional blood collection method,which is worthy of popularization and application.
		2020 Vol. 27 (31): 83-85-89 [Abstract] ( 32 ) HTML (33 KB) PDF (0 KB) ( 13 )

	86	Clinical effect of Tripterygium Glycosides combined with Valsartan in the treatment of patients with stage Ⅳdiabetic nephropathy
		JIN Zhe；MEI Lan
		Objective To explore the clinical effect of Tripterygium Glycosides combined with Valsartan in the treatment of patients with stage Ⅳdiabetic nephropathy.Methods From June 2017 to June 2019,100 patients with stageⅣdiabetic nephropathy admitted to the Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine were selected as the research objects,and they were divided into the observation group (50 cases) and the control group (50 cases) by completely randomized method.The observation group adopted Tripterygium Glycosides combined with Valsartan method,and the control group adopted Valsartan method.The levels of serum creatinine,serum albumin,24 h urine protein,interleukin-6 (IL-6),tumor necrosis factor-α (TNF-α),high-sensitivity C-reactive protein (hs-CRP) and total incidence of adverse reactions were compared in the two groups.Results There were no significant differences in the levels of serum creatinine,serum albumin,24 h urine protein,and inflammatory factors (IL-6,TNF-α,hs-CRP) before treatment between the two groups (P＞0.05).The levels of serum creatinine,24 h urine protein and inflammatory factors (IL-6,TNF-α,hs-CRP) after treatment in the observation group were all lower than those in the control group,and the differences were statistically significant (P＜0.05).The level of serum albumin in the observation group after treatment was higher than that in the control group,and the difference was statistically significant (P＜0.05).The total incidence of adverse reactions in the observation group (4.00%) was lower than that in the control group(18.00%),and the difference was statistically significant (P＜0.05).Conclusion Tripterygium Glycosides method can effectively lighten the inflammatory response and reduce the incidence of adverse reactions in patients with stage Ⅳdiabetic nephropathy,and it is worthy of promotion and application.
		2020 Vol. 27 (31): 86-89 [Abstract] ( 36 ) HTML (35 KB) PDF (0 KB) ( 14 )

	90	Effect of switching different hypoglycemic regimens in the treatment of newly diagnosed type 2 diabetes mellitus after early intensive insulin therapy
		YI Zheng-yuan
		Objective To explore effect of switching different hypoglycemic regimens in the treatment of newly diagnosed type 2 diabetes mellitus after early intensive insulin therapy.Methods A total of 84 patients with newly diagnosed type 2 diabetes mellitus who were admitted to our hospital from January 2017 to January 2018 were enrolled.All of them underwent intensive insulin therapy for 2 weeks.After blood glucose control was qualified,they were divided into the basic insulin group and the oral hypoglycemic group by the random number table method,42 cases in each group.The levels of blood lipid and blood glucose were measured before and after intensive treatment.The follow-up was conducted for 1 year.Results After intensive insulin treatment,triglyceride (TG),total cholesterol (TC),low density lipoprotein-cholesterol (LDL-C),glycated hemoglobin (HbAlc),fasting blood-glucose (FBG) and two hours postprandial blood glucose (2 h PBG) were lower than those before treatment,while fasting insulin (FINS),insulin,homeostatic model assessment of insulin sensitivity (HOMA-IS) and homeostatic model assessment of insulin resistance (HOMA-IR)were higher than those before treatment,the differences were statistically significant (P＜0.05).There were no statistically significant differences in body mass index (BMI),waist-to-hip ratio (WHR),body fat rate and high density lipoprotein-cholesterol (HDL-C) before and after treatment (P＞0.05).One year later,there were no statistically significant differences in HbA1c,FBG,2 h PBG,HOMA-IS and HOMA-IR between the basic insulin group and the oral hypoglycemic group (P＞0.05).Conclusion Intensive insulin therapy can effectively improve levels of blood glucose and blood lipid in patients with newly diagnosed type 2 diabetes mellitus.After intensive treatment,both the use of basic insulin and oral hypoglycemic drugs can achieve satisfactory clinical results
		2020 Vol. 27 (31): 90-92 [Abstract] ( 30 ) HTML (32 KB) PDF (0 KB) ( 16 )

	93	Application of six step cancer notification model in the condition notification of young cervical cancer patients
		WANG Hua-ling；LI Mei-xiang；WAN Xiao-lan
		Objective To explore the application effect of six step cancer notification model in the condition notification of young cervical cancer patients.Methods A total of 66 patients with cervical cancer admitted to our hospital from May to September 2019 were selected as the research objects and divided into two groups according to the random number table method,33 cases in each group.The control group used conventional cancer notification,and the experimental group used six step cancer notification model.The hope levels (Herth hope index [HHI],psychological burden[self-report numeric scale]),quality of life (generic quality of life inventory-74 [GQOLI-74]) of patients and life quality(caregiver quality of life [CQOL]) of caregivers were compared after 2 days of condition notification in the two groups.Results The HHI score of the patients in the experimental group was (34.67±3.24) points,and the self-report numeric scale score was (6.54±1.25) points after 2 days of condition notification,which were higher than those in the control group for (28.54±3.21) and (5.23±1.02) points respectively,the differences were statistically significant (P＜0.05).The GQOLI-74 physical function score of the patients in the experimental group was (53.67±5.33) points,the psychological function score was (50.58±4.89) points,the social function score was (51.54±5.35) points,and the material life score was (51.94±5.69) points,which were higher than the (48.56±5.30),(42.53±4.31),(43.67±5.32),(42.59±5.26) points in the control group respectively,the differences were statistically significant (P＜0.05).The CQOL physical condition score of the caregivers in the experimental group was (67.72±6.11) points,the mental state score was (60.27±5.31) points,the social function score was (62.46±6.14) points,and the mental status score was (67.83±6.11) points,which were higher than those in the control group for (48.52±5.32),(45.64±5.28),(46.83±5.10),(53.67±5.84) points respectively,the differences were statistically significant (P＜0.05).Conclusion Using the six step cancer notification model to inform young cervical cancer patients can improve their life expectancy index,reduce their psychological burden,and improve the life quality of patients and their caregivers.
		2020 Vol. 27 (31): 93-95-99 [Abstract] ( 27 ) HTML (35 KB) PDF (0 KB) ( 12 )

	96	Value comparison of B-ultrasound and CT in the diagnosis of thyroid tumors
		YANG Bin
		Objective To compare of the value of B-ultrasound and CT in the diagnosis of thyroid tumors.Methods A total of 284 patients with thyroid tumors who were admitted to our hospital from January 2016 to January 2019 were selected as the research objects.Color B-ultrasound and spiral CT were carried out respectively.The pathological diagnosis results were used as the gold standard,and the diagnostic coincidence rate,specificity and sensitivity between the two methods were compared.Results In 81 patients with thyroid microcarcinoma (lesion diameter ≤1.0 cm),the diagnostic coincidence rate (76.54%),specificity (54.55%) and sensitivity (84.75%) of B-ultrasound were higher than those of CT (58.02%,27.27%,69.49%),the differences were statistically significant (P＜0.05).Among 203 cases of thyroid cancer (lesion diameter＞1.0 cm),the diagnostic coincidence rate (93.60%),specificity (88.24%) and sensitivity (94.09%)of B-ultrasound were not statistically different from those of CT (90.15%,70.59%,91.94%) (P＞0.05).Conclusion For thyroid microcarcinoma (lesion diameter ≤1.0 cm),the coincidence rate of B-ultrasonic diagnosis is higher than that of CT,while for the lesion diameter ＞1.0 cm,both methods have higher positive diagnosis rate.
		2020 Vol. 27 (31): 96-99 [Abstract] ( 27 ) HTML (33 KB) PDF (0 KB) ( 11 )

	100	Application of Recombinant Human Endostatin Injection anti-angiogenesis combined with chemotherapy in patients with non-small cell lung cancer
		WANG Yan-ru
		Objective To explore the application of Recombinant Human Endostatin Injection anti-angiogenesis combined with chemotherapy in patients with non-small cell lung cancer.Methods A total of 58 patients with non-small cell lung cancer admitted to our hospital from February 2018 to April 2019 were selected as the observation objects.The patients were randomly divided into the study group (29 cases) and the control group (29 cases).The control group was treated with conventional chemotherapy.The study group was treated with Recombinant Human Endostatin Injection anti-angiogenesis combined with chemotherapy.The total effective rate of treatment,the total effective rate of improvement of life quality and the total incidence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the study group was 93.10% and 55.17% in the control group,which in the study group was higher than that in the control group,with statistically significant difference (P＜0.05).The total effective rate of improvement of life quality in the study group was 93.10% and 62.07% in the control group,which in the study group was higher than that in the control group,and the difference was statistically significant (P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups (P＞0.05).Conclusion The application of Recombinant Human Endostatin Injection anti-angiogenesis combined with chemotherapy in the treatment of non-small cell lung cancer can effectively increase the treatment effect,improve the quality of life of patients,and has safety.
		2020 Vol. 27 (31): 100-102 [Abstract] ( 26 ) HTML (32 KB) PDF (0 KB) ( 15 )

	103	Effect of Shengxuebao Mixture on the improvement of bone marrow suppression and quality of life after chemotherapy for leukemia
		YU Jie LI Jin-hong
		Objective To explore the effect of Shengxuebao Mixture on the improvement of bone marrow suppression and quality of life after chemotherapy for leukemia.Methods A total of 80 patients with leukemia who were admitted to our hospital from October 2018 and October 2019 were selected as the subjects.They were divided into the observation group and the control group by the random number table method,with 40 cases in each group.The control group was treated with conventional chemotherapy regimen,the observation group was additionally treated with Shengxuebao Mixture on the basis of the control group.The situation of bone marrow suppression,quality of life and blood test result were compared between the two groups.Results The degree of bone marrow suppression in the observation group was lighter than that in the control group,and the difference was statistically significant (P＜0.05).Before treatment,there was no statistically significant difference in the Karnofsky (KPS) score between the two groups (P＞0.05).After treatment,the KPS score of the observation group was higher than that of the control group,and the difference was statistically significant (P＜0.05).The KPS score of the observation group after treatment was higher than that before treatment,and the difference was statistically significant (P＜0.05).The KPS score of patients in the control group was higher than that before treatment,and the difference was statistically significant (P＜0.05).Before treatment,there were no significant differences in the levels of hemoglobin,white blood cells and platelets between the two groups (P＞0.05).After treatment,the levels of hemoglobin,white blood cells,and platelets of the observation group were higher than those of the control group,and the differences were statistically significant (P＜0.05).The levels of hemoglobin,white blood cells,and platelets of the observation group after treatment were lower than those before treatment,with statistical significances (P＜0.05).The levels of hemoglobin,white blood cells and platelets in the control group after treatment were lower than those before treatment,and the differences were statistically significant (P＜0.05).Conclusion The application of Shengxuebao Mixture can effectively improve the bone marrow suppression and quality of life of patients with leukemia after chemotherapy.
		2020 Vol. 27 (31): 103-105 [Abstract] ( 37 ) HTML (34 KB) PDF (0 KB) ( 17 )

	106	Clinical effect of laparoscopic surgery in the treatment of colorectal cancer
		LYU Yong-zhu；WANG Da-wei；XU Cai；REN Fei
		Objective To investigate the clinical effect of laparoscopic surgery in the treatment of colorectal cancer.Methods Eighty patients who underwent colorectal cancer surgery from January 2018 to December 2019 were selected as the research objects and divided into the control group and the study group according to the random number table method,with 40 cases in each group.In control group,traditional surgery was used,and in study group,laparoscopic surgery was adopted.The operation time,incision length,hospital stay,intraoperative blood loss,incidence of complications and total satisfaction rate after treatment with different surgical methods in the two groups were compared.Results The operation time,incision length,and hospital stay in the study group were shorter than those in the control group,the differences were statistically significant (P＜0.05).The intraoperative blood loss was less than that in the control group,the difference was statistically significant (P＜0.05).The total incidence of complications in the study group was lower than that in the control group,the difference was statistically significant (P＜0.05).The total satisfaction rate of the study group was higher than that of the control group,the difference was statistically significant (P＜0.05).Conclusion In the treatment of colorectal cancer,laparoscopic surgery has an ideal therapeutic effect and should be further promoted and applied in clinic.
		2020 Vol. 27 (31): 106-108-112 [Abstract] ( 26 ) HTML (33 KB) PDF (0 KB) ( 12 )

	109	Clinical effect of point application combined with oral Chinese medicine in the treatment of dysmenorrhea
		WAN Ping；JIANG Gui-lin；WU Fei-hua；ZHOU Xue-ming
		Objective To investigate the clinical effect of point application combined with oral Chinese medicine in the treatment of dysmenorrhea.Methods A total of 93 patients with dysmenorrhea who were treated from March 2018 to December 2019 in the First Affiliated Hospital of Nanchang University were selected and divided into control group (n=46) and observation group (n=47) according to the random number table method.The control group was given oral Shaofu Zhuyu Decoction,while observation group was treated with point application (self-made dysmenorrhea paste)combined with oral Shaofu Zhuyu Decoction.The curative effect,prostaglandin and degree of pain were compared between the two groups.Results The efficacy of observation group was better than that of control group,the difference was statistically significant (P ＜0.05).The peripheral prostaglandin F2α (PGF2α) and peripheral prostaglandin F2α/prostaglandin E2 (PGF2α/PGE2) in observation group were lower than those in control group,while the PGE2 in the observation group was higher than that in control group (P＜0.05).The score of visual analogue scale in observation group was lower than that in control group after treatment,the difference was statistically significant (P ＜0.05).Conclusion Point application combined with oral Chinese medicine in the treatment of dysmenorrhea can decrease the degree of pain,have benign regulative effect on the synthesis of prostaglandin,and increase curative effects.
		2020 Vol. 27 (31): 109-112 [Abstract] ( 31 ) HTML (41 KB) PDF (0 KB) ( 15 )

	113	Application of positive psychological suggestion in breastfeeding
		LIU Yan-ping；LIU Jiang-nan；YAN Xiao-qiong；YANG Huan-xiu；SHI Yun-xi；ZHONG Li
		Objective To analyze the application value of positive psychological suggestion in breastfeeding.Methods A total of 100 primiparas with delivery in our hospital from January to June 2020 were selected and divided into two groups according to random number table method,50 cases in each group.The control group was given routine education and nursing of breastfeeding,and the observation group was given positive psychological suggestion based on the control group.The pain degree of breastfeeding,complications,breastfeeding rate,neonatal weight and maternal satisfaction were compared between two groups.Results The neonatal weight and score of satisfaction in observation group were higher than those in control group,and the score of visual analogue scale (VAS) in observation group was lower than that in control group,the differences were statistically significant (P＜0.05).The exclusive breastfeeding rate of observation group was higher than that of control group,and the total incidence of complications in observation group was lower than that in control group,the differences were statistically significant (P＜0.05).Conclusion Positive psychological suggestion can improve exclusive breastfeeding rate and nursing satisfaction of primipara,relieve pain of breastfeeding,decrease the incidence of complications,and promote neonatal growth and development.
		2020 Vol. 27 (31): 113-115 [Abstract] ( 24 ) HTML (32 KB) PDF (0 KB) ( 18 )

	116	Influence of age on the perinatal complications，the condition of newborn and the mode of delivery
		LI Ying；ZHOU Jun；GUO Ling-li
		Objective To investigate the effect of age on the perinatal complications,neonatal conditions and delivery modes of primary parturient women.Methods A total of 60 cases of primiparas admitted to our hospital from November 2018 to December 2019 were selected as the research objects.According to age,they were divided into control group(30 cases,normal pregnant women) and observation group (30 cases,elderly pregnant women).Complications,neonatal conditions and delivery methods were compared between the two groups.Results The total complication rate of the observation group was higher than that of the control group,the difference was statistically significant (P＜0.05).The total incidence of neonate-related complications in the observation group was higher than that in the control group,the difference was statistically significant （P＜0.05).In the observation group，the proportion of primiparas undergoing cesarean section was higher than that of the control group,the difference was statistically significant (P＜0.05).In the observation group,the proportion of primiparas undergoing natural delivery was lower than that of the control group,the difference was statistically significant (P＜0.05).Conclusion The incidence of maternal and infant complications is high in the perinatal period of elderly primiparas.The rate of cesarean section increases.
		2020 Vol. 27 (31): 116-118 [Abstract] ( 30 ) HTML (29 KB) PDF (0 KB) ( 12 )

	119	Application effect of chest physiotherapy in children with mechanical ventilation
		LONG lin；CHEN Jun；LAI Lin-fen；LIN Hua；OUYANG Yan；ZEN Xin-hua；LUO Kai-yuan；REN Su-qin
		Objective To explore the application effect of chest physiotherapy in children patients with mechanical ventilation.Methods Fifty-six children patients with severe pneumonia and endotracheal intubation admitted to the First Affiliated Hospital of Gannan Medical University from June 2014 to December 2017 were enrolled,and they were randomly divided into observation group (n=28) and control group (n=28).The control group was treated with routine anti-infection and expectorant therapy,while the observation group was treated with respiratory tract management according to chest physiotherapy based on routine treatment.Blood pH,arterial partial pressure oxygen (PaO2),arterial partial pressure of carbon dioxide (PaCO2),chest X-ray improvements,auscultation of lung,oxygen saturation of terminal vein,respiratory rate and hospitalization time in both two groups were observed individually,and the effects of different treatments were compared.Results The pH and PaO2 of arterial blood gas analysis in the observation group were higher than those of control group (P＜0.05).PaCO2 in the observation group was lower than that in control group (P＜0.05).After treatment,the time for improvement of chest X-ray,auscultation,oxygen saturation,respiratory rate and hospitalization time in the observation group were shorter than those in the control group (P＜0.05).Conclusion Compared with routine anti infection and expectorant therapy,chest physiotherapy can improve the blood gas results and various respiratory indexes of children,and can promote the recovery of patients.The chest physiotherapy has a good clinical effect and it is worth spreading.
		2020 Vol. 27 (31): 119-121 [Abstract] ( 34 ) HTML (38 KB) PDF (0 KB) ( 13 )

	122	Effect of Gushen Antai Pills combined with Progesterone in the treatment of early pregnancy uterine effusion
		WANG Ting-ting；YANG Li-juan；ZHANG Yun
		Objective To investigate the effect of Gushen Antai Pills combined with Progesterone in the treatment of early pregnancy uterine effusion.Methods A total of 100 pregnant women admitted to our hospital from January to December 2017 were selected as research subjects.They were divided into experimental group (n=50) and control group(n=50) according to dynamic randomization method.The experimental group was treated with Gushen Antai Pills with Progesterone Injection,and the control group was only treated with Progesterone Injection.The total effective rate,the rate of miscarriage,the amount of uterine fluid and the incidence of adverse reactions after treatment were compared between the two groups.Results The total effective rate and the rate of miscarriage in the experimental group were higher than those in the control group,the incidence of adverse reactions and the total amount of uterine effusion were lower than those in the control group,and the differences were statistically significant (P＜0.05).Conclusion Gushen antai Pills combined with Progesterone in the treatment of uterine effusion has a higher total effective rate,a miscarriage rate,reduce the patient′s uterine effusion,and improve the patient′s pregnancy outcome.
		2020 Vol. 27 (31): 122-124 [Abstract] ( 28 ) HTML (31 KB) PDF (0 KB) ( 15 )

	125	Application effect of Doxycycline combined with Jinfeng Pills in patients with chronic endometritis after hysteroscopy
		LIU qin；LI Yu-ping；WANG Chang-yu
		Objective To explore the clinical effect of Doxycycline combined with Jinfeng Pills in the treatment of chronic endometritis (CE) after hysteroscopy.Methods A total of 130 patients with pathological diagnosis after hysteroscopy who were treated in our hospital from March to December 2019 were diagnosed as CE and required in vitro fertilization-embryo transfer (IVF-ET) infertility patients who assisted in pregnancy.They were divided into control group (n=64) and observation group (n=66) according to the random number table method.The control group was treated with Doxycycline,and the observation group was treated with Doxycycline and Jinfeng Pills.After 14 days of treatment,the total effective rate,endometrial condition,and postoperative IVF-ET pregnancy rate were compared between the two groups.Results The total effective rate of treatment in the observation group was 90.91%,higher than that in the control group of 67.17%,and the difference was statistically significant (P＜0.05).The endometrial remission rate and pregnancy rate after IVF-ET observation in the observation group were 87.88% and 59.09%,higher than those in the control group of 59.38% and 32.81%,respectively,and the differences were statistically significant (P＜0.05).Conclusion Doxycycline combined with Jinfeng Pills has good clinical effect on CE,and it can increase the pregnancy rate after embryo transfer,and it is economical and convenient.It is worthy of clinical promotion.
		2020 Vol. 27 (31): 125-127 [Abstract] ( 25 ) HTML (32 KB) PDF (0 KB) ( 14 )

	128	Effect of Magnesium Sulfate，Nifedipine plus Labetalol in treating pregnancy-induced hypertension patients
		WANG Ying
		Objective To explore the effect of Magnesium Sulfate,Nifedipine plus Labetalol in treating pregnancy-induced hypertension (PIH) patients.Methods A total of 87 PIH patients treated from January to October 2019 in our hospital were selected.According to random number table,patients were divided into reference group (n=43) and research group (n=44).The reference group took Magnesium Sulfate and Nifedipine; the research group took Magnesium Sulfate,Nifedipine combined with Labetalol.Clinical efficacy,hemodynamics and urine protein changes for two groups were compared.Results The total clinical effective rate in the research group (93.18%) was higher than that in the reference group (81.40%),with statistical difference (P＜0.05); after treatment,blood viscosity and erythrocyte ratio in the research group were lower than those in the reference group,with statistical differences (P＜0.05）; after treatment，24 h urine protein，mucoprotein and human urinary kallidinogenase levels in the research group were lower than those in the reference group，with statistical differences （P＜0.05).Conclusion Magnesium Sulfate,Nifedipine combined with Labetalol can remarkably reduce the blood viscosity and erythrocyte ratio,improve 24 h urine protein quantitation and increase therapeutic effects.
		2020 Vol. 27 (31): 128-130 [Abstract] ( 31 ) HTML (33 KB) PDF (0 KB) ( 12 )

	131	Value of serum ferritin and lactate dehydrogenase in the prediction of refractory Mycoplasma pneumoniae pneumonia with children
		LIU Cai-li；MI Pei-ming；LIAO Cui-le
		Objective To observe the expression of serum ferritin (SF) and lactate dehydrogenase (LDH) in children with refractory Mycoplasma pneumoniae pneumonia (RMPP) and its predictive value for RMPP.Methods A total of 282 children with RMPP from October 2016 to October 2018 in our hospital were selected.A total of 180 children with Mycoplasma pneumoiae pneumonia (MPP) and 50 healthy children were selected as MPP group，control group.The expression levels of SF and LDH were detected.The receiver operating characteristic (ROC) curve was used to evaluate the specific indices for predicting RMMP.Results The levels of LDH and SF in RMPP group were higher than those of control group and MPP group (P＜0.05).The levels of LDH and SF in MPP group were higher than those of control group (P＜0.05).The level of LDH was positively correlated with the level of SF (r=0.254,P＜0.05).The AUC,sensitivity and specificity of LDH combined with SF was higher than that of LDH and SF (P＜0.05）.Conclusion The high levels of LDH,SF in children with RMPP can predict RMPP.
		2020 Vol. 27 (31): 131-133 [Abstract] ( 26 ) HTML (30 KB) PDF (0 KB) ( 12 )

	134	Application effect of COOK cervical dilation balloon combined with Oxytocin in elderly full-term multipara
		LI Wan-ping
		Objective To investigate the application effect of COOK cervical dilation balloon combined with Oxytocin in elderly full-term multipara.Methods The clinical data of 88 elderly full-term multiparas who were admitted to our hospital from January 2018 to September 2019 were retrospectively analyzed.They were divided into observation group(n=44) and control group (n=44) according to treatment methods.The observation group was treated with COOK cervical dilation balloon and Oxytocin,and the control group was treated with Oxytocin.The delivery outcome,time of stages of labor,Apgar score and adverse reactions were compared between the two groups.Results The natural delivery rate of observation group was higher than that of control group,and the cesarean section rate of observation group was lower than that of control group,the differences were statistically significant (P＜0.05).The time of first stage of labor,time of second stage of labor and the time of total stage of labor in observation group were shorter than those in control group(P＜0.05).There were no statistical differences in the neonatal birth weight and Apgar score between observation group and control group (P＞0.05).The total incidence of adverse reactions in observation group was lower than that in control group,the difference was statistically significant (P＜0.05).Conclusion COOK cervical dilation balloon combined with Oxytocin in treatment of elderly full-term multipara can increase natural delivery rate,shorten the time of total stage of labor,and decrease the incidence of adverse reactions,which has no great effect on the newborns.
		2020 Vol. 27 (31): 134-136-140 [Abstract] ( 24 ) HTML (33 KB) PDF (0 KB) ( 22 )

	137	Effect of Low Molecular Weight Heparin Calcium on umbilical artery blood flow indexes of fetal growth restriction
		YANG Lin；WANG Jia-yuan
		Objective To investigate the effect of low molecular weight heparin calcium on umbilical artery blood flow indexes of fetal growth restriction.Methods A total of 80 pregnant women with fetal growth restriction who were admitted to our hospital from March 2018 to September 2019 were selected,and they were divided into two groups according to random number table method,40 cases in each group.The control group was given routine treatment,and observation group was given Low Molecular Weight Heparin Calcium based on the control group.The umbilical artery blood flow (umbilical artery flow resistance index [RI],umbilical artery peak systolic velocity/diastolic peak velocity [S/D]),maternal coagulation function indexes (activated partial thromboplastin time [APTT],prothrombin time [PT]) and neonatal Apgar score were compared between the two groups.Results There were no statistical differences in the umbilical artery flow indexes between two groups before treatment (P＞0.05).After treatment,the umbilical artery blood flow indexes in two groups were lower than those before treatment,and observation group was lower than control group,the neonatal Apgar score of observation group was higher than that of control group,and the differences were statistically significant (P＜0.05).There were no statistical differences in the maternal coagulation function indexes between two groups before and after treatment (P＞0.05).Conclusion Low Molecular Weight Heparin Calcium in treatment of fetal growth restriction can improve fetal umbilical artery blood flow indexes,increase neonatal Apgar score,and not affect coagulation function of pregnant women,which is worthy of clinical application.
		2020 Vol. 27 (31): 137-140 [Abstract] ( 27 ) HTML (33 KB) PDF (0 KB) ( 13 )

	141	Clinical application of Methylene Blue staining one day before operation in anterior ear fistula resection
		HU Yu-long；HUANG Yong-gang；XIE Wen-min；LUO Wei；SHAN Xin XU Jin-ling
		Objective To investigate the clinical application of Methylene Blue staining in preauricular fistula removal.Methods A collection of 133 patients with preauricular fistula admitted to our hospital from January 2015 to June 2019 were selected as the research objects.All patients were in the non-inflammatory period,and the preauricular fistula with infection was completely controlled after 2 weeks of infection.The patients with preauricular fistula and infection were divided into observation group(67 cases)and control group(66 cases)by random number table method.The observation group received Methylene Blue staining one day before the operation and the control group received Methylene Blue staining before the ear fistula removal.All patients were followed up for more than 6 months after operation,and the wound healing,residual fistula recurrence,complications and patient satisfaction were compared between the two groups.Results The incisions in the observation group healed at first stage without recurrence after the operation.There were 2 cases with large preauricular scars after operation,and the total incidence of complications was 2.98%; the patient satisfaction rate was 97.01%.In the control group,there were 6 cases of residual fistula recurrence after the operation,the recurrence rate was 9.09%,and the healing was good after the second operation; 9 cases had large scars after operation,2 cases were infected,and the total incidence of complications was 16.67%; patient satisfaction was 83.33%.The postoperative incision healing rate and satisfaction of the observation group were higher than those of the control group,and the recurrence rate and the total incidence of complications were lower than those of the control group,the differences were statistically significant(P＜0.05).Conclusion Preauricular fistula removal after Methylene Blue staining 1 day before surgery has the advantages of less trauma and fewer complications,which is beneficial to complete removal of fistula lesions,reduces recurrence rate,and improves patient satisfaction.
		2020 Vol. 27 (31): 141-143 [Abstract] ( 32 ) HTML (34 KB) PDF (0 KB) ( 14 )

	144	Clinical effect of Hydroxyglycoside Eye Drops combined with Pranoprofen Eye Drops in the treatment of dry eye
		CUI Shi-chao
		Objective To investigate the clinical effect of Hydroxyglycoside Eye Drops combined with Pranoprofen Eye Drops in the treatment of dry eye.Methods A total of 50 patients with dry eye treated in Fushun Ophthalmopathy Hospital from May 2018 to August 2019 were selected as the research objects.They were divided into the control group(25 cases) and the study group (25 cases) according to random number table method.The patients in control group were treated with Hydroxyglycoside Eye Drops,and the patients in study group were treated with Hydroxyglycoside Eye Drops combined with Pranoprofen Eye Drops,they were treated for 2 weeks.The treatment effect and tear film rupture time,tear secretion,and quality of life were compared between two groups.Results The total effective rate of treatment in the study group was higher than that of the control group,and the difference was statistically significant (P＜0.05).Before treatment,there were no significant differences in tear film rupture time,tear secretion volume and quality of life scores between the two groups (P＞0.05); tear film rupture time after treatment in the two groups was longer than that before treatment,and tear secretion was more than that before treatment,the quality of life score was higher than that before treatment,and the differences were statistically significant (P＜0.05); after treatment,the tear film rupture time of the study group was longer than that of the control group,and the amount of tear secretion was more than that of the control group,the quality of life score was higher than that of the control group,the differences were statistically significant(P＜0.05).Conclusion Hydroxyglycoside Eye Drops combined with Pranoprofen Eye Drops can significantly prolong the tear film rupture time of dry eye,increase tear secretion,and at the same time improve the quality of life of patients.It has an ideal effect and is worthy of promotion.
		2020 Vol. 27 (31): 144-146 [Abstract] ( 27 ) HTML (31 KB) PDF (0 KB) ( 17 )

	147	Anesthetic effect of Dexmedetomidine pre-injection before laryngeal microsurgery
		HE Ting-yu；LIU Xiao-cheng；LI You-chun
		Objective To analyze the anesthetic effect of Dexmedetomidine pre-injection before patients received laryngeal microsurgery.Methods A total of 72 patients achieved laryngeal microsurgery admitted in our hospital from January 2018 to October 2019 were selected as research objects and divided into the control group and the study group by random number table method,with 36 cases in each group.Patients in the control group received conventional anesthesia,while patients in the study group received Dexmedetomidine pre-injection before surgery.The heart rate,mean arterial pressure and total incidence of adverse reactions were compared between the two groups.Results The heart rate and mean arterial pressure of the patients in the study group were lower than those in the control group,and the differences were statistically significant (P＜0.05).The total incidence of adverse reactions in the study group (5.6%)was lower than that of the control group (30.6%),and the difference was statistically significant (P＜0.05).Conclusion Dexmedetomidine pre-injection before patients received laryngeal microsurgery has a better anesthetic effect,and this scheme can be promoted in such patients.
		2020 Vol. 27 (31): 147-149 [Abstract] ( 27 ) HTML (32 KB) PDF (0 KB) ( 14 )

	150	Effect of dual frequency index monitoring on postoperative delirium in elderly patients undergoing laparoscopic surgery under general anesthesia
		LI Xiao-li
		Objective To investigate the effect of dual frequency index (BIS) monitoring on postoperative delirium in elderly patients undergoing general anesthesia laparoscopic surgery.Methods A total of 80 patients undergoing laparoscopic surgery in the Fourth Affiliated Hospital of Nanchang University from March 2018 to October 2019 were selected as the research objects,and they were divided into the control group (40 cases) and the study group (40 cases).The control group used the anesthesiologist′s clinical experience medication method,and the research group used the BIS monitoring method.The intraoperative conditions,hemodynamic conditions at different time points,and the incidence of postoperative delirium were compared between the two groups.Results The total amount of Propofol used in the study group and the amount of Propofol induction during the operation were less than those of the control group,and the differences were statistically significant (P＜0.05); the recovery time and the time of leaving the room in the study group were shorter than those of the control group,the differences showed statistical significance (P＜0.05); the average pulse pressure and heart rate of the study group at different time points were lower than those of the control group,the differences were statistically significant (P＜0.05); and at 1 d after operation,the incidence of delirium in the study group was lower than in the control group,the difference was statistically significant (P＜0.05); there was no statistically significant difference in the incidence of delirium at 2,3,and 4 d after the operation between the two groups (P＞0.05).Conclusion The application of BIS monitoring anesthesia in elderly laparoscopic surgery can reduce the use of Propofol,shorten the recovery and recovery time of patients,avoid hemodynamic drastic fluctuations,reduce the incidence of postoperative delirium,and make the application of anesthesia safer.
		2020 Vol. 27 (31): 150-152-156 [Abstract] ( 25 ) HTML (34 KB) PDF (0 KB) ( 12 )

	153	Application effect of clear vision intubation soft lens in the positioning of double-lumen bronchial catheter
		YE Li-qun；LUO Bin；LI Xue-yu
		Objective To investigate the clinical effect of visual intubation soft lens (VIS) in the positioning of doublelumen bronchial catheter (DLT).Methods A total of 60 patients who admitted to our hospital from February 2018 to October 2019 for elective thoracic surgery requiring one-lung ventilation were selected as research subjects and divided into the control group and the observation group according to the random number table method,with 30 cases in each group.All patients underwent aspiration combined with general anesthesia.The control group achieved chest auscultation and the observation group achieved VIS positioning.The total positioning accuracy,the total incidence of complications,the positioning time of double-lumen bronchial catheter and the vital signs were compared between the two groups.Results The total positioning accuracy of the observation group was higher than that of the control group,and the difference was statistically significant (P＜0.05).The total incidence of complications in the observation group was lower than that in the control group,and the difference was statistically significant (P＜0.05).The positioning time of left and right double-lumen bronchial catheter in the observation group were shorter than those in the control group,and the differences were statistically significant (P＜0.05).During the positioning period,there were no statistically significant differences in pulse oxygen saturation,partial pressure of carbon dioxide at the end of respiration and mean arterial pressure between the two groups (P＞0.05).Conclusion The VIS in the positioning of DLT has higher positioning accuracy,can shorten the positioning time,reduce the complication rate,and the vital signs index is stable.It is worthy of clinical promotion and application.
		2020 Vol. 27 (31): 153-156 [Abstract] ( 29 ) HTML (38 KB) PDF (0 KB) ( 17 )

	157	Application study of ultrasound-guided saphenous nerve block in high ligation and stripping of great saphenous vein
		ZHANG Wen-ting；LI Xiao-yong
		Objective To explore the application effect of ultrasound-guided saphenous nerve block in high ligation and stripping of great saphenous vein.Methods From March 2019 to May 2020,a total of 60 patients with high ligation and stripping of great saphenous vein in Pingxiang People′s Hospital were selected and divided into two groups by the random number table method,30 cases in each group.The control group received laryngeal mask anesthesia,and the observation group received ultrasound-guided saphenous nerve block.The pain visual analogue scale (VAS) score at each time point after operation and adverse reactions were compared.Results The VAS score of the observation group was (1.98±0.37) points at the 1 h after operation,and at the 48 h after operation it was (3.43±0.35) points,and the VAS score at 1 h and 48 h after operation in the control group were (1.96±0.38) points and (3.59±0.41) points respectively,there was no significant difference between the two groups(P＞0.05);the VAS scores of the observation group at 4,8,24 h after operation were (2.28±0.63) points,(2.51±0.60) points and (2.77±0.59) points,respectively,they were lower than those in the control group which were (2.89±0.49) points,(3.03±0.45) points and (3.64±0.52) points,the differences were statistically significant (P＜0.05); the total incidence of adverse reactions of the observation group was 6.67%,it was lower than that in the control group which was 26.67%,the difference was statistically significant(P＜0.05).Conclusion Ultrasound-guided saphenous nerve block in the application of high ligation and stripping of great saphenous vein has exact effect,remarkable blocking effect,can effectively relieve postoperative pain,with few adverse reactions and high safety.
		2020 Vol. 27 (31): 157-159 [Abstract] ( 28 ) HTML (31 KB) PDF (0 KB) ( 11 )

	160	Application value of continuous noninvasive blood pressure monitoring in elderly patients undergoing surgery
		YUAN Hai-bo；YIN Lin；NIE Ji-ying
		Objective To analyze the application value of continuous noninvasive blood pressure monitoring in elderly surgical patients.Methods A total of eighty elderly patients undergoing surgery in Yichun People′s Hospital from February 2018 to February 2020 were selected as the research objects,and the patients were divided into the control group (40 cases) and the observation group (40 cases) according to the random number table method.The patients in observation group accepted continuous non-invasive blood pressure monitoring measurement; the patients in control group received traditional non-invasive invasive arterial continuous pressure measurement.The comfort,blood pressure,postoperative complications,hospitalization cost and hospitalization time of the two groups were compared.Results Intraoperative diastolic blood pressure,systolic blood pressure and mean arterial pressure were not statistically different between the two groups (P>0.05); the comfort score of the observation group was higher than that of the control group at 1 h after surgery,and the difference was statistically significan (P＜0.05); the incidence of postoperative acute myocardial injury and postoperative delirium in the observation group was lower than that of the control group,and the difference was statistically significant (P＜0.05); the hospitalization time was shorter than that in the control group,and the cost of hospitalization in the observation group was less than that in the control group,the differences were statistically significant (P＜0.05).Conclusion Non-invasive blood pressure monitoring has comprehensive monitoring parameters,and it is non-invasive,which is ideal for elderly patients undergoing general anesthesia surgery.
		2020 Vol. 27 (31): 160-162 [Abstract] ( 26 ) HTML (33 KB) PDF (0 KB) ( 12 )

	163	Application effect of Dexmedetomidine combined with Namefen Hydrochloride on laryngeal mask anesthesia in children
		GAN Guang-sheng；LIAO Wan-dong；LIU Xin-ai
		Objective To investigate the application effect of Dexmedetomidine combined with Nmefene Hydrochloride on laryngeal mask anesthesia in children.Methods A total of 70 children who underwent pediatric laryngeal mask anesthesia in Dongguan Taixin Hospital from April 2017 to June 2019 were selected,they were divided into the study group and the control group according to the random number table method,each group had 35 cases.Children in both groups were treated with routine anesthetic drugs such as Propofol,Sufentanil and Sevoflurane,the control group used Dexmedetomidine,the study group used Dexmedetomidine combined with Namefen Hydrochloride.The breathing of the children after anesthesia,recovery and adverse reactions were observed.Results After anesthesia,the respiratory rate and heart rate of the study group were higher than those of the control group,with statistically significant differences(P＜0.05); the waking time,spontaneous breathing recovery time and laryngeal mask extraction time of the study group were shorter than those of the control group,with statistically significant differences (P＜0.05); the overall incidence of adverse reactions in the study group (2.86%) was lower than that in the control group (17.14%),and the difference was statistically significant (P＜0.05).Conclusion Dexmedetomidine combined with Namefen Hydrochloride has a significant effect on laryngeal mask anesthesia in children,with low adverse reactions.
		2020 Vol. 27 (31): 163-165 [Abstract] ( 28 ) HTML (31 KB) PDF (0 KB) ( 12 )

	166	Application value of the best puncture path design of preoperative multislice CT in puncture of percutaneous kyphoplasty
		CUI Xiao-rong；LI Shi-liang；SUN Hai-dong；ZHU Xiao-ming；Lian Yu-cai；LI Xiang-yang；LI Yu-min；WU Ning
		Objective To explore the application value of the best puncture path design of preoperative multi-slice CT(MSCT) in percutaneous kyphoplasty (PKP) in the treatment of osteoporotic compression fracture of thoracolumbar spine in PKP.Methods From January 2016 to December 2019,40 patients (46 vertebrae) with brittle compression fractures and PKP minimally invasive treatment were selected and divided into the experimental group (20 cases,25 vertebrae)and the control group (20 cases,21 vertebrae) by random lot.MSCT was used to design the best puncture path in the experimental group before operation,while routine puncture was performed under C-arm fluoroscopy in the control group.The intraoperative fluoroscopy times,operation time,intraoperative bone cement dispersion over the midline,and postoperative VAS scores of low back pain were compared between the two groups.Results All patients successfully completed the operation.In the experimental group,there were 3 cases of bone cement leakage,including 1 case of vertebral space leakage,1 case of paravertebral leakage and 1 case of prevertebral leakage.In the control group,there were 5 cases of bone cement leakage,including 1 case of vertebral space leakage,2 cases of paravertebral leakage and 2 cases of prevertebral leakage,all of which had no serious complications.The operation time of the experimental group was shorter than that of the control group,the exposure times of C-arm of the experimental group was less than that of the control group,the vas of lumbago pain of the experimental group was lower than that of the control group,the differences were statistically significant (P ＜0.05).The mumb of cement diffuses beyond that midline cone in the experimental group was more than that in the control group,the difference was statistically significant (P ＜0.05).Conclusion For patients with thoracolumbar fragile compression fracture,the bone cement dispersion effect of PKP is better than that of C-arm fluoroscopy,and the number of puncture is significantly reduced,the operation time is shortened,and the number of radiation exposure of doctors and patients is reduced.The operation of this technology is simple and the safety is higher.
		2020 Vol. 27 (31): 166-168 [Abstract] ( 24 ) HTML (33 KB) PDF (0 KB) ( 13 )

	169	Value of Holter combined with treadmill exercise test in the diagnosis of coronary heart disease
		YANG Yong-chun；LIAO Hong-ying；TANG Fang
		Objective To investigate the significance of Holter combined with exercise plate test in the diagnosis of coronary heart disease.Methods A total of 50 patients suspected with coronary heart disease admitted to Ganzhou People′s Hospital from March 2018 to July 2019 were selected as subjects for the study.Holter and Holter combined with treadmill exercise test were respectively performed for patients to analyze the effects of two different diagnostic methods.Results The true positive of diagnosis result of the combined test was 45 cases,and the true positive diagnosis of Holter was 40 cases.The diagnostic coincidence rate and sensitivity of the combined examination were higher than those of Holter,and the missed diagnosis rate was lower than that of Holter,the differences were statistically significant(P＜0.05).Conclusion Holter combined with treadmill exercise test has the characteristics of high coincidence rate and sensitivity in the diagnosis of coronary heart disease,and has high clinical application value.
		2020 Vol. 27 (31): 169-172 [Abstract] ( 28 ) HTML (35 KB) PDF (0 KB) ( 13 )

	173	Clinical study on hemodynamics of patients with ovarian endometriosis cyst by color Doppler ultrasound
		WANG Cha-hua
		Objective To explore the clinical value of color Doppler ultrasound in monitoring the hemodynamics of patients with ovarian endometriosis cyst.Methods From January 2017 to January 2019，52 patients with ovarian endometriosis cyst in our hospital were selected as the study group，and 52 healthy women who had physical examinations in our hospital at the same time were selected as the control group.All the patients in the study group were treated with ovarian endometrial cyst resection.All the subjects were examined by color Doppler ultrasound.The levels of progesterone，estradiol and uterine artery hemodynamics in the study group and the control group were compared，and the hemodynamic changes before and after operation in the study group were recorded.Results There was no significant difference in the uterine artery resistance index （RI） between the two groups （P＞0.05）.However，the uterine artery RI of the study group was significantly higher than that of the control group，the difference was statistically significant （P＜0.05）.The levels of progesterone and estradiol in the study group were lower than those in the control group，the differences were statistically significant （P＜0.05）.The systolic diastolic peak velocity ratio （S/D），uterine artery RI and pulsatile index （PI） of the patients in the study group were lower than those before operation，the differences were statistically significant （P＜0.05）.Conclusion Color Doppler ultrasound can clearly show the uterine artery blood flow and estrogen levels such as progesterone and estradiol in patients with ovarian endometrios′s cyst，which can provide reliable basis for clinical treatment.
		2020 Vol. 27 (31): 173-175 [Abstract] ( 28 ) HTML (31 KB) PDF (0 KB) ( 10 )

	176	Comparison of application between magnetic resonance imaging and multislice spiral CT in the diagnosis of pancreatic cystic lesions
		ZHU Feng
		Objective To investigate and compare the application effect of magnetic resonance imaging (MRI) and multilayer spiral CT (MSCT) in the diagnosis of pancreatic cystic lesions.Methods From November 2018 to November 2019,a total of 53 patients with pancreatic cystic lesions admitted to our hospital were selected as the research subjects.All patients were examined with MRI,MSCT sequentially before operation.Final surgical pathology examination was used as the gold standard for diagnosis,and the application effect of MRI,MSCT examination in the diagnosis of pancreatic cystic lesions was compared,and the examination time of the two methods was compared.Results Among the 53 patients,14 cases were pseudocyst,5 cases were true cyst,9 cases were mucinous cystic tumor,7 cases were serous cystic tumor,6 cases were solid pseudopapillary tumor,8 cases were intraductal papillary myxoma and 4 cases were cystadenocarcinoma according to pseudocyst by postoperative pathology.With the postoperative pathological results as the gold standard,the coincidence rate of MRI,MSCT examination and diagnosis of pancreatic cystic lesions was 98.11% and 92.45%,and there was no significant difference between the two methods (P＞0.05).The examination time of MSCT was (19.6±3.2) min,which was shorter than (28.7±4.1) min of MRI,the difference was statistically significant (t=5.351,P＜0.05).Conclusion In the diagnosis of pancreatic cystic lesions,MRI and MSCT examination methods can get relatively accurate diagnosis effect,the time of MSCT is relatively short,the examination is faster,while the MRI examination can carry on the comprehensive scan from the multi-directional,provides the more sac changes related information,the clinical application may choose the suitable examination way according to the actual situation.
		2020 Vol. 27 (31): 176-178 [Abstract] ( 26 ) HTML (30 KB) PDF (0 KB) ( 12 )

	179	Clinical efficacy study of needle warming moxibustion combined with Buzhong Yiqi Decoction addition and subtraction in the treatment of postpartum urinary retention
		WU Shan；WANG Lei；XIE Shu-qin
		Objective To investigate the clinical efficacy of needle warming moxibustion combined with Buzhong Yiqi Decoction addition and subtraction in treatment of postpartum urinary retention.Methods A total of 80 pregnant women with postpartum urinary retention who ended the pregnancy in the maternity ward of our hospital from June 2019 to February 2020 were selected as the study objects and divided into the study group and the control group according to random number table control method,with 40 cases in each group.The study group was treated with needle warming moxibustion combined with Buzhong Yiqi Decoction addition and subtraction and the control group was treated with western medicine.The treatment effect,indwelling rate of the catheter,the first micturition time,the residual urine volume of the bladder and postpartum quality of life scores were compared between the two groups.Results The total effective rate of the study group was higher than that of the control group,the indwelling rate of the catheter was lower than that of the control group,and the differences were statistically significant (P＜0.05).The first micturition time of the study group was shorter than that of the control group,the residual urine volume of the bladder was less than that of the control group,and the differences were statistically significant (P＜0.05).The scores of postpartum emotional function,physical function,social function,role function and cognitive function in the study group were higher than those in the control group,and the differences were statistically significant (P＜0.05).Conclusion Needle warming moxibustion combined with Buzhong Yiqi Decoction addition and subtraction is effective in treatment of postpartum urinary retention,and it can effectively improve urination and quality of life of pregnant women.
		2020 Vol. 27 (31): 179-181-196 [Abstract] ( 32 ) HTML (34 KB) PDF (0 KB) ( 12 )

	182	Clinical effect of Sanzi Yangqin Decoction addition and subtraction in the treatment of accumulation of phlegm and dampness in lung type of cough variant asthma
		WANG Hong-jing；ZHENG Yuan-fang
		Objective To investigate the clinical effect of Sanzi Yangqin Decoction addition and subtraction combined with Compound Methoxyphenamine Hydrochloride Capsules in the treatment of accumulation of phlegm and dampness in lung type of cough variant asthma.Methods A total of 60 patients with accumulation of phlegm and dampness in lung type of cough variant asthma who admitted in our hospital from March to June 2019 were selected as research objects and divided into the control group and the experimental group randomly,with 30 cases in each group.Patients in the control group received Compound Methoxyphenamine Hydrochloride Capsules,while the patients in the experimental group received Sanzi Yangqin Decoction addition and subtraction combined with Compound Methoxyphenamine Hydrochloride Capsules.All patients were treated for 4 weeks.The therapeutic effects,daytime and night cough scores and traditional Chinese medicine (TCM) symptom scores of the two groups were compared before and after treatment.Results The total effective rate of the experiment group was higher than that of the control group,and the difference was statistically significant (P＜0.05).The daytime and night cough scores and TCM symptom scores of the experiment group after treatment were lower than those of the control group,and the differences were statistically significant (P＜0.05).Conclusion Sanzi Yangqin Decoction addition and subtraction combined with Compound Methoxyphenamine Hydrochloride Capsules can improve the clinical symptoms of patients,and it is worthy of clinical promotion and application.
		2020 Vol. 27 (31): 182-184 [Abstract] ( 32 ) HTML (34 KB) PDF (0 KB) ( 10 )

	185	Research trends of vascular dementia based on CiteSpace
		LI Xuan；WANG Yi-guo；WU Zao-xia
		Objective To understand the research trends of neurosciences and clinical neurology of vascular dementia in the past 6 years.Methods The relevant literatures collected in Web of Science (WOS) from 2013 to 2018 were searched by using the method of sequential search method,with the help of CiteSpace 5.4.R3,the cooperative relationship among authors,countries and institutions and the co-occurrence of keywords were analyzed,and the co-citation of literatures was visualized.Results A total of 2923 articles of documents were obtained,with an average annual publication volume of nearly 487 articles,and the annual publication volume showed an upward trend,2016 and 2018 were hot research years.The United States ranks first in the world in terms of volume of publications,and the country with the highest central ranking were Austria.The University of Washington in the United States was the institution with the most papers,and the University of Newcastle in the United Kingdom ranked highest in institutional centrality.The author with the highest number of posts was Na DL,and the author with the most influence was Esiri MM.Hot research keywords included Alzheimer′s disease,dementia,stroke,risk factors,small blood vessel disease,white matter high signal,cognitive impairment,and so on.Conclusion CiteSpace is used to analyze the literature related to neuroscience and clinical neuroscience of vascular dementia in recent 6 years,to show the current development trend,and which can provide reference for further research.
		2020 Vol. 27 (31): 185-188 [Abstract] ( 28 ) HTML (35 KB) PDF (0 KB) ( 12 )

	189	Analysis on the risk factors of falls in the elderly people in nursing institutions
		FU Li；LI Xiu-huan；PAN Shu-fen；LIN Gui-yong
		Objective To analyze the risk factors of falls in the elderly people in nursing institutions.Methods The data of 197 elderly people in a institutions home from August 2018 to November 2019 were analyzed retrospectively.The Chinese version of Morse fall risk assessment scale was used to assess the fall risk of the elderly.According to the scores,the participants were divided into the low and moderate risk group (64 cases) and the high risk group (133 cases).The data of demographic sociology and physical condition of the two groups were compared,and the related risk factors were analyzed.Results The proportion of women,advanced age,poor visual acuity,chronic diseases,long-term medication,poor balance function,and the incidence of falls in the past three months in the high-risk group were higher than those in the low-risk and medium-risk group,the differences were statistically significant (P＜0.05).Women,advanced age,poor visual acuity,chronic diseases,long-term medication,poor balance function,and fall history in the past three months were independent risk factors for falls in the elderly (P＜0.05).Conclusion Women,advanced age,poor visual acuity,chronic diseases,long-term medication,poor balance function,and fall history in the past three months were independent risk factors for falls in the elderly.
		2020 Vol. 27 (31): 189-191 [Abstract] ( 29 ) HTML (32 KB) PDF (0 KB) ( 16 )

	192	Analysis on the changes of cesarean section rate and the indication of cesarean section from 2012 to 2019 in our hospital
		CHEN Xiao-yun
		Objective To study the changes of cesarean section rate and indication of cesarean section in our hospital from 2012 to 2019.Methods A total of 20 289 pregnant women who labor in the First Affiliated Hospital of Fujian Medical University from January 1,2012 to December 31,2019 were selected,among which 11 010 were delivered by cesarean section.The cesarean section rates in each year were compared,the trend of changes in indications of cesarean section operation were analyzed,and the measures of reducing the cesarean section rate were proposed.Results The rate of cesarean section in our hospital decreased year by year from 2012 to 2019.The rate of cesarean section in 2019 was 50.500%,which was lower than that of 61.159% in 2012,and the difference was statistically significant (P＜0.05).Social factors and scar uterus ranked first and second among all indications of cesarean section operation.The proportion of scar uterus increased year by year,and it ranked second in the first two years and jumped to the first place in the next six years.On the contrary,the proportion of social factors has decreased year by year,it ranked the first in 2012-2013,the second in 2014-2018,and fell to the fourth in 2019,there were differences in comparison between the years (P＜0.05).The pregnancy comorbidities and complications increased year by year,while the abnormal labor decreased year by year，the differences between the years were statistically significant (P＜0.05).Conclusion The cesarean section rate of our hospital has decreased year by year in the past 8 years,but it is still relatively high.The main reason is the increased number of pregnant women with scarred uterus,pregnancy comorbidities and complications.The indications of the first cesarean section should be strictly controlled,the cesarean section without medical indications should be reduced as far as possible,the new stage of labor should be standardized,the full trial production should be given,and the vaginal delivery rate should be increased,so as to achieve the ultimate goal of reducing the cesarean section rate.
		2020 Vol. 27 (31): 192-196 [Abstract] ( 29 ) HTML (38 KB) PDF (0 KB) ( 12 )

	197	Effect of empathy training on the empathy level and patient satisfaction of triage nurses in outpatient services
		ZHANG Hui-bin；LUO Jin-yun
		Objective To investigate the effect of empathy training on the empathy level and patient satisfaction of triage nurses in outpatient services.Methods From October to December in 2019,56 triage nurses in outpatient services in Bao′an Central Hospital of Shenzhen were selected.Three months of empathy training intervention was conducted,and the triage nurses′ empathy levels were assessed after interventional measures.Patient satisfaction and complaint rate of the triage nurses before and after the interventions were compared among all the patients who had effectively submitted the questionnaires.Results The total scores of empathy ability of outpatient triage nurses and patients′satisfaction with outpatient nurses after intervention were higher than those before the interventions,and the total number of complaints was lower than that before the intervention,with statistically significant differences (P＜0.05).Conclusion Empathy training can improve the empathy level of the triage nurses in outpatient services and patient satisfaction as a result,therefore reducing the number of complaints caused by service factors.
		2020 Vol. 27 (31): 197-199-204 [Abstract] ( 27 ) HTML (34 KB) PDF (0 KB) ( 13 )

	200	A retrospective analysis of the causes of long-term hemodialysis catheter extubation in hemodialysis patients
		ZENG Yan；CHEN You-ming
		Objective To explore the causes of long-term hemodialysis catheter extubation in hemodialysis patients.Methods A retrospective analysis of 66 patients with long-term hemodialysis catheters removed due to catheter loss(hereinafter referred to as "loss of function") in Fujian Provincial Hospital from August 2013 to August 2018.The system sampling method was adopted to obtain 66 patients with normal catheter function for the control group.The general data and laboratory data of the two groups were collected as observation items.The observation items were analyzed by the statistical method to sum up the relevant risk factors of the extubation.Results There were 419 cases who met entry criteria and the rate of out-of-work extubation was 15.75%.The main causes of the out-of-work were that the function of the catheter was not good,the infection of the catheter and the withdrawal of the catheter,and the rates were 48.48%,24.24% and 21.21% respectively.The results of univariate analysis showed that there were statistically significant differences in age,blood flow,thrombotic history,serum albumin,total cholesterol,lipoprotein a,carbon dioxide binding capacity,and C-reactive protein between the failure extubation group and the control group (P＜0.05).The results of multivariate analysis suggested that age (β=0.053,OR=1.062,95%CI=1.007-1.120),C-reactive protein (β=0.057,OR=1.054,95%CI=1.011-1.098),blood flow (β=-0.034,OR=0.968,95%CI=0.944-0.993),lipoprotein a (β=0.003,OR=1.003,95%CI=1.000-1.565) were related factors (P＜0.05).Among them,the OR of age and CRP were greater than 1,and the OR of blood flow was less than 1,for catheter failure,advanced age,high CRP，and low blood flow were considered as the independent risk factors; the OR of lipoprotein a was greater than 1,but the 95% confidence interval included 1,so high lipoprotein a was considerd as an independent risk factor.Conclusion Advanced age and high CRP are independent risk factors for long-term catheter failure,and blood flow is an important reference factor,and lipoprotein a has an important significance for further study.Among them,the significance of C-reactive protein is the most clear,and it is necessary to carry out long-term continuous monitoring.
		2020 Vol. 27 (31): 200-204 [Abstract] ( 28 ) HTML (37 KB) PDF (0 KB) ( 15 )

	205	Effect of risk management on self-management behavior and the incidence of adverse events in patients with maintenance hemodialysis
		CHEN Zhong-mei
		Objective To investigate the effect of risk management on self-management behavior and the incidence of adverse events in patients with maintenance hemodialysis.Methods A total of 60 patients with maintenance hemodialysis admitted in our hospital from April 2018 to December 2019 were selected as the research objects and divided into the control group and the observation group according to random number table method,with 30 cases in each group.The control group was given routine nursing,and the observation group was given risk management on the basis of the control group.The scores of self-management behavior,total incidence of adverse events and nursing total satisfaction rate after 1 month of nursing were compared between the two groups.Results The self-management behavior score of the observation group ([86.13±7.69]points) was higher than that of the control group ([74.22±8.32]points),the total incidence of adverse events (10.00%) was lower than that of the control group (40.00%),the nursing total satisfaction rate(99.67%) was higher than that of the control group (66.67%),and the differences were statistically significant (P＜0.05).Conclusion Risk management for patients with maintenance hemodialysis can improve self-management behavior and reduce the incidence of adverse events.
		2020 Vol. 27 (31): 205-208 [Abstract] ( 26 ) HTML (35 KB) PDF (0 KB) ( 12 )

	209	Application of medical ethics construction in clinical nursing in the new period
		WANG Shu-xin
		Objective To explore the application of medical ethics construction in clinical nursing in the new period.Methods A total of 54 medical staff who work in our hospital and 65 hospitalized patients in digestive internal medicine department from February 2017 to February 2018 before the construction of medical ethics,at the same time,a total of 54 medical staff who work in our hospital and 65 hospitalized patients in digestive internal medicine department from March 2018 to March 2019 after the construction were selected as the research objects.The nursing total satisfaction,treatment total compliance of patients and medical ethics of the medical staff were compared.Results The nursing total satisfaction,treatment total compliance of patients and medical ethics of the medical staff after the construction of medical ethics were higher than those before the construction,and the differences were statistically significant (P＜0.05).Conclusion The development of medical ethics education activities can effectively promote the treatment compliance and nursing satisfaction of patients,and it is worthy of clinical promotion and application.
		2020 Vol. 27 (31): 209-211-215 [Abstract] ( 24 ) HTML (33 KB) PDF (0 KB) ( 13 )

	212	Application effect of "6S" combined with visual management method in reducing unqualified blood samples in outpatient blood collection room
		JIANG Chun-ying；ZHANG Hua-xiu
		Objective To explore the application effect of "6S" combined with visual management method in reducing unqualified blood samples in outpatient blood collection room.Methods Since June 2018,the "6S" combined with visual management method was carried out in the blood collection room of the outpatient department of the hospital.The rates and causes of unqualified blood samples in the outpatient department before (May 2018) and after (December 2018) the implementation of the "6S" combined with visual management method were compared.Results After the implementation of "6S" combined with visual management method,the rate of unqualified blood samples in December 2018 (0.0136%) was lower than that in May 2018 (0.0587%),and the difference was statistically significant (P＜0.05).The nurse factor in the unqualified blood samples in December 2018 (1 cases) was less than that in May 2018 (10 cases),the factor of coding and sticking nurse attendant in December 2018 (9 cases) was less than that in May 2018 (32 cases),the factor of blood feeder in December 2018 (4 cases) was less than that in May 2018 (19 cases).Conclusion The "6S" combined with visual management method is helpful to reduce the unqualified blood samples in the blood collection room,alleviate the pain of patients,improve the working efficiency of the staff in the blood collection room,improve the nursing quality and nursing management level.
		2020 Vol. 27 (31): 212-215 [Abstract] ( 26 ) HTML (38 KB) PDF (0 KB) ( 12 )

	216	Effect of targeted nursing on negative emotions and sleep quality of early threatened abortion patients
		WAN Yan
		Objective To explore the effect of targeted nursing on negative emotion and sleep quality in patients with early threatened abortion.Methods A total of 92 patients with early threatened abortion received from Jiangxi Maternal and Child Health Hospital from January to November 2018 were divided into observation group and control group according to the cointoss method,46 cases in each.The control group received routine nursing,and the observation group performed targeted nursing.The two groups of patients were compared with the self-rating anxiety scale (SAS),the self-rating depression scale (SDS),the Pittsburgh sleep index scale (PSQI),and the quality of life rating scale (SF-36)score.Results The SAS score,SDS score,and PSQI scores of the observation group were lower than those of the control group on the 7th day of admission,at discharge and 1 month after discharge,and the differences were statistically significant (P＜0.05); The scores of SF-36 on the 7th day of admission,atdischarge and 1 month after discharge in the observation group were higher than those of the control group,and the differences were statistically significant (P＜0.05).Conclusion Targeted nursing in patients with early threatened abortion can effectively reduce negative emotions,improve sleep quality and improve quality of life.
		2020 Vol. 27 (31): 216-219 [Abstract] ( 28 ) HTML (40 KB) PDF (0 KB) ( 12 )

	220	Influence of humanistic care as a nursing intervention on the self-care ability,mental state and quality of life of patients undergoing laryngeal cancer surgery
		DUAN Liu-hua；LI Ming
		Objective To explore the effect of humanistic care as a nursing intervention in patients undergoing laryngeal cancer surgery.Methods A total of 94 patients with laryngeal cancer were admitted to our hospital from November 2015 to November 2019 were selected as the research subjects.They were divided into the control group and the observation group according to the random number table,47 cases in each group.The control group received routine nursing,while the observation group received humanistic care.The scores of exercise of self-care agency (ESCA) scale,mental state including self-rating anxiety scale (SAS),self-rating depression scale (SDS),and core quality of life(QLQ-C30) scale were compared between the two groups before intervention and 7 days after intervention.Results There were no statistically significant differences in ESCA score,SAS score,SDS score,or QLQ-C30 score between the two groups before intervention (P＞0.05).In the observation group,the scores of ESCA self-care concept,health knowledge,self-care responsibility,and self-care ability after the intervention all higher than those of the control group,the differences were statistically significance (P＜0.05).The SAS and SDS scores of the observation group after intervention were lower than those of the control group,the differences were statistically significance (P＜0.05).The scores of QLQC30 emotional function,physical function,cognitive ability,social function,family role function in the observation group after intervention were all higher than those of the control group,the differences were statistically significance(P＜0.05).Conclusion Humanistic care as a nursing intervention can enhance the self-care ability of patients undergoing laryngeal cancer surgery,improve the negative emotions,and ameliorate the QOL.
		2020 Vol. 27 (31): 220-223 [Abstract] ( 24 ) HTML (34 KB) PDF (0 KB) ( 12 )

	224	Application effect of seamless management on nursing premature infants with bronchopulmonary dysplasia
		ZHAO Xiao-yan；LUO Mei-fen
		Objective To explore the application effect of seamless management on nursing premature infants with bronchopulmonary dysplasia.Methods A total of 110 premature infants with bronchopulmonary dysplasia who were admitted to our hospital from January 2016 to March 2019 were selected as research subjects.According to the random number table,they were divided into control group (n=55) and observation group (n=55).The control group received routine nursing model,and the observation group received seamless management based on the control group.After nursing,the effects of the two groups were evaluated.The lung function and nursing quality score at discharge and 6 months after discharge in the two groups were compared.Results There was no significant difference between the two groups in terms of indicators at discharge (P＞0.05).6 months after discharge,the vital capacity,expiratory flow rate,and expiratory volume of the two groups were higher than those at discharge,and the differences were statistically significant (P＜0.05),and the vital capacity,expiratory flow rate,and expiratory volume of the observation group were all higher than those of the control group,the differences were statistically significant (P＜0.05).The scores of satisfaction,basic nursing,health promotion,and ward management in the nursing quality of the observation group were higher than those of the control group,the differences were statistically significant (P＜0.05).Conclusion The seamless management for premature infants with bronchopulmonary dysplasia has a remarkable clinical effect,and can effectively increase the quality of clinical nursing scores and exert a positive effect on premature infants with bronchopulmonary dysplasia,which is worthy of promotion and application.
		2020 Vol. 27 (31): 224-226-230 [Abstract] ( 27 ) HTML (34 KB) PDF (0 KB) ( 12 )

	227	Value analysis of protective effect of high quality nursing in patients with nasopharyngeal carcinoma undergoing intensity modulated radiotherapy
		HU Chun-yi； HU Jing；XU Yan
		Objective To explore the effect of high quality nursing in patients with nasopharyngeal carcinoma undergoing intensity modulated radiation therapy.Methods A total of 90 patients with nasopharyngeal carcinoma treated by intensity modulated radiation therapy from July 2018 to December 2019 in the First People′s Hospital of Fuzhou were selected as the study subjects.They were divided into the control group and the experimental group according to the random number table method，45 cases in each group.The control group was given routine nursing，while the experimental group was given high quality nursing intervention on the basis of routine nursing.The oral mucositis reaction grade and pain improvement before and after nursing were compared between the two groups.Results The grading of oral mucositis reaction in the experimental group after nursing was better than that in the control group,and the difference was statistically significant （P＜0.05）.There was no significant difference in visual analogue scale (VAS) score between the two groups before nursing （P＞0.05）.The scores of VAS in the two groups after nursing were lower than those before nursing，and the score of VAS in the experimental group after nursing was lower than that in the control group，the differences were statistically significant （P＜0.05）.Conclusion High quality nursing intervention can play a good role in protecting the oral mucosa of patients with nasopharyngeal carcinoma undergoing intensity modulated radiation therapy，which can significantly reduce the reaction of oral mucositis，and effectively alleviate the pain of patients，which is worthy of clinical promotion and application.
		2020 Vol. 27 (31): 227-230 [Abstract] ( 30 ) HTML (34 KB) PDF (0 KB) ( 12 )

	231	Application effect of evidence-based nursing in patients with pre-hospital emergency sputum aspiration via oropharyngeal ventilation tube
		ZENG Fang-lan LU Shu-mei LI Cui PENG Yong-fu
		Objective To explore the application effect of evidence-based nursing in patients with pre-hospital emergency sputum aspiration via oropharyngeal ventilation tube.Methods A total of 90 cases of patients admitted to our hospital from January to August 2019 for pre-hospital emergency sputum aspiration via oropharyngeal ventilation were selected as research objects.According to the random number table method,they were divided into the control group(n=45) and the observation group (n=45).The control group was given routine nursing,and the observation group was given evidence-based nursing.The length of stay,comfort level of sputum aspiration,frequency of sputum aspiration,duration of sputum aspiration,blood gas analysis indexes,total incidence of adverse reactions and interval of sputum aspiration were compared between the two groups.Results The length of stay in the observation group was shorter than that of the control group,the comfort level of sputum aspiration was higher than that of the control group,the frequency of sputum aspiration was less than that of the control group,and the duration of sputum aspiration was shorter than that of the control group,the differences were statistically significant (P＜0.05).There were no statistically significant differences in SaO2 and PaCO2 between the two groups 30 minutes before sputum aspiration (P＞0.05).SaO2 in the observation group 30 minutes after sputum aspiration was higher than that 30 minutes before sputum aspiration,and PaCO2 was lower than that in the control group (P＜0.05).The total incidence of adverse reactions in the observation group was lower than that in the control group,and the interval of sputum aspiration was longer than that in the control group,with statistical differences (P＜0.05).Conclusion The application effect of evidence-based nursing in pre-hospital emergency sputum aspiration via oropharyngeal ventilation tube can significantly improve the comfort of sputum aspiration,shorten the interval of sputum aspiration,and reduce the incidence of adverse reactions.
		2020 Vol. 27 (31): 231-234 [Abstract] ( 27 ) HTML (41 KB) PDF (0 KB) ( 8 )

	235	Application effect of humanistic care in perioperative period of breast cancer patients
		JIANG Xue
		Objective To explore the application effect of humanistic care in the perioperative period of breast cancer patients.Methods A total of 100 patients with breast cancer who underwent surgical treatments in our hospital from January 2018 to December 2019 were selected.They were divided into control group and experimental group according to the random number method,50 cases in each group.In the control group,conventional nursing was used,while in the experimental group,humanistic care was adopted.The self-care ability,quality of life,nursing satisfaction and occurrence of complications of the two groups were compared.Results There was no statistically significant difference in self-care ability between the two groups before nursing (P＞0.05).The self-care ability of the two groups after nursing was higher than that of before nursing,the self-care ability of the experimental group was higher than that of the control group,with statistical differences (P＜0.05).The difference in the quality score of life of the two groups before nursing was not statistically significant (P＞0.05).The quality scores of life of the two groups after nursing were higher than those before nursing,the quality of life score of the experimental group was higher than that of the control group,the differences were statistically significant (P＜0.05).The nursing total satisfaction of the experimental group was 90.00%,higher than that of the control group accounting for 70.00%,with statistical difference (P＜0.05).The total incidence of complications in the experimental group was 6.00%,lower than that in the control group accounting for 20.00%,and the difference was statistically significant (P＜0.05).Conclusion Carrying out humanistic care for breast cancer patients during perioperative period can effectively improve self-care ability,quality of life,and nursing satisfaction and reduce the incidence of complications,so it is worth applying and promoting.
		2020 Vol. 27 (31): 235-237 [Abstract] ( 30 ) HTML (33 KB) PDF (0 KB) ( 11 )

	238	Research on the rehabilitation effect of continuous nursing cognitive intervention for patients with schizophrenia
		TIAN Feng-xiang
		Objectives To explore the rehabilitation effect of continuous nursing cognitive intervention for patients with schizophrenia.Methods A total of 80 hospitalized patients with schizophrenia who were treated in Rongfu Military Hospital of Jining city in Shandong Province were selected as subjects from September to December 2019.According to the cluster grouping method,they were divided into study group (40 cases) and control group (40 cases).Both groups were given systemic antipsychotic medication and nursing care.The control group was given regular health education.The study group was given continuous nursing cognitive intervention.The intervention time of the two groups was eight weeks.After the intervention,the cognitive level of continuous nursing scale and brief psychiatric rating scale were used to evaluate the rehabilitation effect of the two groups.Results Before the intervention,the level of continuous nursing cognitive and illness state were not significant statistical differences between the two groups (P＞0.05); After intervention,the total average score of the level of continuous nursing cognitive and their each dimension scores in the study group were higher than those in the control group,the differences were statistically significant (P＜0.05).The total score of brief psychiatric rating scale in the study group was lower than that in the control group,the difference was statistically significant (P＜0.05).Conclusion Continuous nursing cognitive intervention can better promote the recovery of patients with schizophrenia.
		2020 Vol. 27 (31): 238-241-245 [Abstract] ( 22 ) HTML (38 KB) PDF (0 KB) ( 13 )

	242	Application effect of comfortable nursing in patients with chronic obstructive pulmonary disease
		YANG Yue
		Objective To explore the effect of comfortable nursing in patients with chronic obstructive pulmonary disease.Methods A total of 120 patients with chronic obstructive pulmonary disease treated in our hospital from May 22,2018 to May 22,2019 were selected as the research subjects.They were divided into observation group (60 cases) and control group (60 cases) according to the single and double numbers,the observation group received comfortable nursing,and the control group received conventional nursing.The forced expiratory volume in 1 second/forced vital capacity(FEV1/FVC),FEV1,arterial oxygen saturation (SaO2),nursing service satisfaction,quality of care satisfaction,compliance behavior,and accident total rate were compared between the two groups.Results Observation group′s satisfaction with nursing service (96.67%),satisfaction with nursing quality (98.33%),compliance with medical practice (100.00%),FEV1([2271.36±5.81]ml),FEV1/FVC (75.97±5.46),SaO2 ([96.68±1.75]%) were higher than the control group′s satisfaction with nursing service (76.67%),satisfaction with nursing quality (83.33%),compliance behavior (86.67%),FEV1([2162.15±4.59]ml),FEV1/FVC (66.13±4.55),SaO2 ([92.33±1.65]%),the differences were statistically significant (P＜0.05).The total incidence of accidents in the observation group (1.67%) was lower than that in the control group (20.00%),and the difference was statistically significant (P＜0.05).Conclusion Comfort nursing is effective for patients with chronic obstructive pulmonary disease,which can improve nursing satisfaction and lung function,also reduce the incidence of accidents.
		2020 Vol. 27 (31): 242-245 [Abstract] ( 33 ) HTML (37 KB) PDF (0 KB) ( 12 )

	246	Application of Xiao′s double-C nursing mode in hemodialysis patients with chronic renal failure
		ZHAO Lin-lin
		Objective To study the effect of Xiao′s double-C nursing mode in hemodialysis patients with chronic renal failure.Methods A total of 102 patients with chronic renal failure hemodialysis who were admitted to our hospital from October 2017 to May 2019 were selected as the research objects,and they were divided into control group (n=51,routine care) and observation group (n=51,Xiao′s double C nursing mode) according to the random number table method,and the blood urea nitrogen(BUN),blood creatinine(SCr)levels,nursing comfort,quality of life scores,and the incidence of complications between the two groups before and after nursing were compared.Results There were no significant differences in the levels of BUN and SCr between the two groups before nursing (P＞0.05).After different nursing interventions,the levels of BUN and SCr in the two groups were lower than before nursing,and the observation group were lower than those of the control group,the differences were statistically significant (P＜0.05).The nursing comfort of the observation group (96.08%) was higher than that of the control group (78.43%),the difference was statistically significant(χ2=8.264,P＜0.05).There was no significant difference in the quality of life scores between the two groups before nursing (P＞0.05).The quality of life scores of the two groups increased after different nursing interventions,and the observation group was higher than that of the control group,with statistically significant difference (P＜0.05).The incidence of complications in the observation group was 9.80%,which was lower than the control group (29.41%),the difference was statistically significant (χ2=9.214,P＜0.05).Conclusion During the clinical treatment of patients with chronic renal failure hemodialysis,the Xiao′s double-C nursing mode is given auxiliary care,which promotes the relief of the clinical symptoms of the patients,and improves the comfort and quality of life of the patients during the treatment.The incidence of postoperative complications is reduced,the effect is significant,and the value of clinical promotion is high.
		2020 Vol. 27 (31): 246-248-252 [Abstract] ( 27 ) HTML (34 KB) PDF (0 KB) ( 11 )

	249	Application effect of node flow navigation nursing in patients with acute ischemic stroke
		ZENG Jiu-hua
		Objective To observe the application effect of node flow navigation nursing in patients with acute ischemic stroke.Methods Retrospective analysis of 120 patients with acute ischemic stroke admitted to our hospital from January 2018 to August 2019 were selected as the study objects.According to whether implemented node process navigation nursing,the patients were divided into control group (January to October 2018) and experimental group (November 2018 to August 2019),60 cases in each group.The patients in the control group were given routine nursing,and the patients in the experimental group were given emergency nursing according to the node flow guidance.The opening time of vein channel,rescue time,completion time of CT examination,time from admission to thrombolysis,thrombolysis rate,rescue success rate,neurological deficit score,cognitive function score and life activity ability score were compared between the two groups.Results The venous opening time,rescue time,CT completion time,and the time from hospital admission to thrombolysis in the experimental group were shorter than those in the control group,and the differences were statistically significant (P＜0.05).The rates of thrombolysis and rescue in the experimental group were higher than those in the control group,and the differences were statistically significant (P＜0.05).After intervention,the neurological deficit score (NFD) in the experimental group was lower than that of the control group,and the scores of mini mental state examination (MMSE) and activity of daily life (ADL) in the experimental group were higher than those of the control group,the differences were statistically significant (P＜0.05).After the intervention,the NFD scores of the experimental group and the control group were lower than those before intervention,the MMSE and ALD scores were higher than those before intervention,with statistically significant differences (P＜0.05).Conclusion The use of node flow navigation nursing to provide first-aid intervention for acute ischemic stroke patients can significantly improve the first-aid timeliness of such emergency care subjects,obtain better rehabilitation outcomes,and be recognized by emergency care recipients.
		2020 Vol. 27 (31): 249-252 [Abstract] ( 28 ) HTML (33 KB) PDF (0 KB) ( 12 )

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