早期胰岛素强化治疗后转换不同降糖方案治疗新诊断2型糖尿病的效果

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Abstract Objective To explore effect of switching different hypoglycemic regimens in the treatment of newly diagnosed type 2 diabetes mellitus after early intensive insulin therapy.Methods A total of 84 patients with newly diagnosed type 2 diabetes mellitus who were admitted to our hospital from January 2017 to January 2018 were enrolled.All of them underwent intensive insulin therapy for 2 weeks.After blood glucose control was qualified,they were divided into the basic insulin group and the oral hypoglycemic group by the random number table method,42 cases in each group.The levels of blood lipid and blood glucose were measured before and after intensive treatment.The follow-up was conducted for 1 year.Results After intensive insulin treatment,triglyceride (TG),total cholesterol (TC),low density lipoprotein-cholesterol (LDL-C),glycated hemoglobin (HbAlc),fasting blood-glucose (FBG) and two hours postprandial blood glucose (2 h PBG) were lower than those before treatment,while fasting insulin (FINS),insulin,homeostatic model assessment of insulin sensitivity (HOMA-IS) and homeostatic model assessment of insulin resistance (HOMA-IR)were higher than those before treatment,the differences were statistically significant (P＜0.05).There were no statistically significant differences in body mass index (BMI),waist-to-hip ratio (WHR),body fat rate and high density lipoprotein-cholesterol (HDL-C) before and after treatment (P＞0.05).One year later,there were no statistically significant differences in HbA1c,FBG,2 h PBG,HOMA-IS and HOMA-IR between the basic insulin group and the oral hypoglycemic group (P＞0.05).Conclusion Intensive insulin therapy can effectively improve levels of blood glucose and blood lipid in patients with newly diagnosed type 2 diabetes mellitus.After intensive treatment,both the use of basic insulin and oral hypoglycemic drugs can achieve satisfactory clinical results

Key words： Newly diagnosed type 2 diabetes mellitus;Hypoglycemic Intensive insulin therapy Early

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YI Zheng-yuan. Effect of switching different hypoglycemic regimens in the treatment of newly diagnosed type 2 diabetes mellitus after early intensive insulin therapy[J]. 中国当代医药, 2020, 27(31): 90-92.

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https://www.dangdaiyiyao.com/EN/ OR https://www.dangdaiyiyao.com/EN/Y2020/V27/I31/90

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