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Quick Search     Adv Search 2016 Vol. 23, No. 21 Published: 2016-07-28   4 Determ ination of the contents of four types of anthraquinones in danshixiao capsules via RP-HPLC m ethod HE Qing-yan;ZHANG Zhi-min;LIU Can-huang Objectiv e To establish the content determination method of rhein，emodin，chrysophanol and physcion in Danshixiao capsules via RP-HPLCmethod.M ethods Waters SunFire C18column（250 mm×4.6mm，5μm）was adopted，andmethanol-0.1%phosphate（85∶15）was selected asmobile phase，with flow rate∶1.0ml/min，column temperature∶28℃，and determination wavelength∶254 nm.Results Sample size of rhein，emodin，chrysophanol and physcion was within the range of 0.132 08-0.792 48μg，0.087 52-0.525 12μg，0.111 84-0.671 04μg，and 0.080 16-0.480 96μg respectively，which showed favorable linear relations with peak areas.The correlation coefficient was 0.9998，0.9996，0.9994 and 0.9997 respectively，the average recovery ratewas99.32%，98.80%，99.05%，99.14%respectively，and RSD was0.76%（n=9），1.31%（n=9），1.41%（n=90），0.94%（n=9）respectively.Conclusion The method is easy to operate，with high specificity，high accuracy and good reproducibility，which is able to be taken as the quality controlmethod of Danshixiao capsules. 2016 Vol. 23 (21): 4-7 [Abstract] ( 126 ) HTML (46 KB)  PDF  (0 KB)  ( 29 ) 8 Effect of hydrogen sulfide on intimal hyperp lasia of vein grafts in the rat YANG Hong-wei;WANG Zu-hui;CHEN Heng;ZHU Guo-xian;LITao;TAN Yi-hua Objective To investigate the effect of hydrogen sulfide on intimal hyperplasia in the rat vein grafts.M ethods External carotid vein transplantation model of rats was established，24male rats were randomly divided into the control group and experimental group，each group of 12，the experimental group was given the administration of the hydrogen sulfide donor NaHS，control group was given the same dose of normal saline，2 weeks and 4 weeks after excision of transplanted vein respectively，computer image analysis system was used tomeasure intimal and medial thickness in the endometrium was calculated，mmunohistochemicalmethod was used to detect vein graft smoothmuscle cell proliferation nucleus（PCNA）expression，statistical analysis of all rats intimal thickness and intimal sectional area，the PCNA index was given.Results Two groups of VG were kept unobstructed，at the time of taking no thrombosis and occlusion，the experimental group and control group of vein grafts in endometrium and the thickness of themembrane after surgery were significantly increased，while the experimental group in the endometrium，compared with control group，intimal thickness 2 weeks and 4 weeks after surgery was increased lighter，with significant difference（P＜0.05）；the two groups of VG in the PCNA positive cellsmainly distributed in near the lumen side and innermembranes in VG PCNA index after surgery，in the experimental group and control group were reduced obviously，and compared with control group，the experimental group in the endometrium，intimal thickness，2 weeks and 4 weeks after surgery was reduced lighter，with significant difference（P＜0.05）.Conclusion Exogenous hydrogen sulfide can effectively restrain the aortic smooth muscle cell proliferation and promote its apoptosis，inhibition of vein graft intimal hyperplasia，it is advantageous to the prevention of the occurrence of restenosis bridge，it isworth clinical for further promotion. 2016 Vol. 23 (21): 8-10 [Abstract] ( 138 ) HTML (39 KB)  PDF  (0 KB)  ( 30 ) 11 Influence of strontium ranelate on tibial bone defect healing in rats w ith osteoporosis YANGMiao-miao;MA Yong-qing Objective To discuss the influence of strontium ranelate on tibial bone defect healing in rats with osteoporosis.Methods 30 female SD rats of 3months old were selected and randomly divided into sham operation group（n= 5）and the other 15 rates were given bilateral ovariectomy.At 12 weeks after operation，5 rats were random ly selected as model group.Rats in the sham operation group and the model group were sacrificed，and bone mineral density（BMD）and bonemineral content（BMC）of tibia andmandibular alveolar process were determined.The other 10 ratsweremade bilateral tibial bone defect and randomly divided into two groups.Rats in group A were given strontium ranelate gavage，and those in group B were given same volume of saline gavage.After 12 weeks of intervention，the rats in both groups were sacrificed to obtain their bilateral tibia and mandible model.The healing condition of tibial bone defect was observed，the osteogenesis condition of tibial bone defectwas detected by tissue sections，and BMD and BMC ofmandibular alveolar process were determined.Resu lts At 12 weeks of operation，the weight gain was significantly higher in the model group than that in the sham operation group（P＜0.01），and the BMD and BMC were significantly lower in the model group than those in the sham operation group（P＜0.01）.At 12 weeks of drug intervention after tibial bone defect operation，general healing of tibia could be observed.The general observations between group A and group B showed no significant difference.Results of HE staining showed that osteogenesis wasmore significant at bone defect in group A than that in group B，and BMD and BMC of mandibular alveolar process were significantly higher in group A than in group B（P＜0.01）.Conclusion Strontium ranelate has a positive effect on bone defecthealing in ratswith osteoporosis. 2016 Vol. 23 (21): 11-13转18 [Abstract] ( 159 ) HTML (47 KB)  PDF  (0 KB)  ( 29 ) 14 The accurate targeted therapeutic research progressof renal cell carcinoma CHEN Xu;ZHANGHong-xiu;NIEMing-xiu;LIWei Renal cell carcinoma（RCC）originates from urinary tubules′epithelial system of ren al parenchyma.It often occurs in one side of kidney.It is one of themost common malignant tumors in urinary system.Angiogenesis，the lack of VHL gene or mutation，two major signal pathways excessively activated of Raf/MEK/ERK and PI3K/AKT/mTOR lead the happenning and development of RCC.However RCC isn′t sensitive to conventional radiotherapy and chemotherapy，hormone therapy and biological treatment along with huge side effects.Therefore，accurate targeted therapy is often used for RCC now.Patients after relative genes and markers detection，are taken drug combination to target precisely for differences.It largely improves the efficiency of the treatment，and reduces the side effects.After a period of treatment of RCC，drug resistance always appears.Drug resistance is divided into acquired drug resistance and primary drug resistance，seriously affecting the therapeutic effect and prognosis of patients.Reviewing the pathogenesis of accurating targeted therapy and drug resistance of RCC is the aimsof this article. 2016 Vol. 23 (21): 14-17 [Abstract] ( 149 ) HTML (54 KB)  PDF  (0 KB)  ( 36 ) 19 Advances in extractive，separative and purificative techniques research of Panax notoginseng saponins MA Zhen-qiong;PU Jun-xue;QU Yun-lian;ZHANG Heng Panax notoginseng saponins（PNS），as themain active ingredient of Panax notoginseng，which has a variety of pharmacological effects and clinical applications，and it is widely used in medicine，health products，cosmetic products and other industries.With the rising demand for PNS，extracting and separating and purifying technologies of PNS are particularly important.Currently，the studying on extractive，separative and purificative technology for PNS are especially more，considering its extraction rate，economy，large-scale production and other factors，using one of the first and formostmethod，which is the frequently-usemethod that of extracting and separating and purifying PNS from Panax notoginseng，firstly adopts the technique of ethanol refluxing extraction，then uses themethod ofmacroporous resin adsorption to separate and purify PNS，and parts of them also combine with enzymolysis approach and alcohol precipitation approach to prepare PNS.In this paper，the commonly used techniques in laboratory research，which are themethods of extracting and separating and purifying PNS from medicinalmaterial Panax notoginseng in recent years，are reviewed to provide the reference to the further studying on PNSand industrial production. 2016 Vol. 23 (21): 19-22转36 [Abstract] ( 152 ) HTML (62 KB)  PDF  (0 KB)  ( 29 ) 23 Expresses and significance of serum soluble triggering receptor expressed on m yeloid cells-1 in patientsw ith infaction of orthopaedics GUO Yong-xian;SONG Shi-jiang;ZHOU Xian-wei;FANG Zhong-wei;CHEN Yun-hao;LIN Xue-lin Ob jective To explore the serum concentration change of serum soluble triggering receptor expressed on myeloid cells-1（sTREM-1）from the orthopaedic infection patients and to find a new objective index for clinical diagnosis.M ethods 30 patientswith orthopaedic infection from April 2015 to March 2016 in our hospital were selected as the infection group，30 healthy people were selected as the control group.The fasting venous blood was collected in the earlymorning of all the cases.The serum concentration of sTREM-1 was determined by ELSIA method，and the results were statistically analyzed.Resu lts The average concentration of sTREM-1 in the infection group was higher than that in the control group，with significant difference（P＜0.05）.The positive rate of infection group was 93.3%，which was higher than 10.0%in the control group，with significant difference（P＜0.05）.Conclusions sTREM-1 is a valuable predictor for the early diagnosis of blood stream orthopaedic infection.The rising of the serum concentration of sTREM-1 suggests the presence of infection，excluded other infections，which provides strong evidence to guide the reasonable use of antibiotics. 2016 Vol. 23 (21): 23-25 [Abstract] ( 145 ) HTML (38 KB)  PDF  (0 KB)  ( 22 ) 26 Correlation study between abnormal blood glucose index and pregnancy outcome in pregnantwomen w ith gestational diabetesm ellitus XIE Ling Objective To explore the correlation between abnormal blood glucose index and pregnancy outcome in pregnantwomen with gestational diabetesmellitus（GDM）.M ethods 1200 pregnant women with GDM in our hospital from April 2015 to April 2016 were selected as the observation group，who were divided into group A，group B，group C according to the different blood glucose levels，the fasting glucose of all subgroups was abnormal.420 cases of pregnant women combined normal blood sugar after 1 hour or 2 hours of taking glucose were selected as the observation group A，460 cases of pregnantwomen combined abnormal blood sugar after 1 hour or 2 hours of taking glucose were selected as the observation group B，320 cases of pregnant women combined abnormal blood sugar after 1 hour of taking glucose were selected as the observation group C.Another 1185 cases of pregnant women with normal blood sugar in our hospital physical examinated at the same period were selected as the control group，the pregnancy outcome in each group was compared.Results The labor rate of greater than gestational age and premature births，cesarean section rate and the incidence rate of total complication in the observation group was higher than that in the control group，with significant difference（P＜0.05）.The all pregnancy outcome proportion of the observation group Bwas higher than that of the observation group A and C，with significant difference（P＜0.05）.The cesarean section rate of in the observation group C was 56.88%，which was higher than 29.76%in the observation group A，with significant difference（P＜0.05）.Conclusion There is a certain relationship between abnormal blood glucose index of GDM pregnantwomen and pregnancy outcome，the increase in the number of abnormal blood glucose in pregnantwomen can increase the probability of adverse pregnancy outcome. 2016 Vol. 23 (21): 26-28 [Abstract] ( 157 ) HTML (37 KB)  PDF  (0 KB)  ( 39 ) 29 Clinical observation of intravenous thrombolysis combined w ith tirofiban in the treatment of ST-segment elevation acutem yocardial infarction CAIMei-lian Objective To observe the efficacy and safety of intravenous thrombolysis with alteplase combined with domestic tirofiban in the treatment of ST-segment elevation acutemyocardial infarction（STEAMI）.M ethods 30 STEAMI patients admitted to our hospital from May 2012 to July 2013 were selected as the conventional group.These patients met theWHO diagnostic criteria，and could receive thrombolytic therapy≤3 hours and underwent coronary angiography（CAG）within 7 days.32 STEAMIpatients admitted to our hospital from September 2013 to November 2014 were selected as the combination group，and was given thrombolysis with alteplase and tirofiban therapy simultaneously.Patients from both groups were additionally given heparin injection via continuous intravenous infusion for 48 hours，ECG，myocardial enzymogram，activated partial thromboplastin time and CAG were recorded.The indicators of coronary recanalization and adverse drug reaction were observed，and the short-term efficacy and safety were evaluated.Results The peak value of CK-MB，peak time of CK-MB，the resolution of ST segment≥50%and in-hospitalmyocardial infarction for a second time between the combination group and the conventional group were not significant difference（P＞0.05）. Therewere significant differences in 5-7 days infarct-related artery（IRA）blood flow＞TIMIgradeⅢand the occurrence of unstable angina within seven days between the two groups（P＜0.05）.Prothrombin time prolongations at 24 h after thrombolysis between the two groups were significantly different（P＜0.05）.Platelet counts and bleeding events between the two groups were no significant difference（P＞0.05）.Conclusion Intravenous thrombolysis combined with domestic tirofiban hydrochloride in the treatment of STEAMI≤3 hours is superior to the conventional thrombolysis group in improving the infarct-related artery TIMI blood flow，the non-occurrence of unstable angina within 7 days，which is not increase the risk of bleeding. 2016 Vol. 23 (21): 29-32 [Abstract] ( 162 ) HTML (41 KB)  PDF  (0 KB)  ( 38 ) 33 Analysis of drug resistance of antiviral treatment in patients w ith AIDS and study on treatment strategy WANG Hai-jian;ZHANG Feng-chi;ZHOU Chang-yue;LIU Cheng-yong;ZHANG Li-ning Objective To understand the immune response，viral suppression and drug resistance of AIDSpatients in our city after antiviral treatment，so as to improve the therapeutic effect.M ethods 52 cases of AIDS patients in Xuzhou Center for Disease Control Prevention and Xuzhou Infectious Disease Hospital from January 2011 and August 2013 were selected as the research group，antiviral therapy with 2 nucleoside reverse transcriptase inhibitors（NRTI）and 1 non-nucleoside reverse transcriptase inhibitors（NNRTI）was used to 52 patients，CD4+cell count and viral load were observed with 6，12，18，24 months，and the drug resistance was detected by＞1000 copy/ml.Results Before antiviral treatment，the average value of CD4+cells in 52 patients was（181±112）/μl，after 6 months of treatment，the average value of CD4+cellswas（272±106）/μl，which was higher than that before treatment，with significant difference（t=2.013，P＜0.05）.Viral load was in a high level in most patients before treatment，71.15%（37/52）was decreased to a low level after treatment.Drug resistance rate was 12.5%（1/8），33.33%（3/9），35.29%（6/17），and 44.44%（8/18）respectively in the treatment of 6，12，18 and 24months.Themutation sites of nucleoside resistance were relatively concentrated，mainly in the 184V mutation，and highly resistant to lamivudine，zidovudine，stavudine.The mutation sites of non nucleoside resistance were scattered，probably happened in 181C，103N，101E，190A and 108L，and highly resistant to efavirenz and nevirapine.Conclusion Antiviral therapy can effectively control the virus disease，improve the level of cellular immunity，and effectively inhibit the replication of HIV virus. W ith the prolongation of treatment time，drug resistant strains to nucleoside and non-nucleoside drugs are in large numbers.Drug resistancemutation is the result of viral suppression，and the poor compliance is themain reason. 2016 Vol. 23 (21): 33-36 [Abstract] ( 165 ) HTML (40 KB)  PDF  (0 KB)  ( 36 ) 37 Drug resistance features of producing extended-spectrum beta-lactamase of Pneumonia klebsiella bacteria and related factors analysis of resulting to bloodstream infection CHEN Ke-fan;XIONG Yu-jiao;LUO Fei;YUAN Shu-sheng Objective To explore the clinical features，drug resistance and related factors that results to bloodstream infection of producing extended-spectrum beta-lactamase（ESBLs）of Pneumonia klebsiella bacteria.M ethods 46 patients with ESBLs of Pneumonia klebsiella bacteria infection in our hospital from January 2013 to January 2015 were selected as the research group.All patients were conducted bacteriological examination and drug sensitivity test after admission. The drug resistance of producing ESBLs of Pneumonia klebsiella bacteria was observed.The related factors of the bloodstream infection group and the non-bloodstream infection group were analyzed，and the related factors that results to bloodstream infection were observed.Results Drug sensitivity test of 46 producing ESBLs of Pneumonia klebsiella bacteria showed that ampicillin had the highest drug resistance rate（100.00%），then wasmacrodantin（89.13%），cefotaxime（80.43%）.The lowest was imipenem（0.00%），amoxicillin was 28.26%and both of piperacillin and tobramycin was 30.43%.Hospital stays，diabetic，antibiotic use types andmechanical ventilation were the related factors of producing ESBLs of Pneumonia klebsiella bacteria resulted to bloodstream infection.Multi factor Logistic regression analysis of the above factors found that hospital stays，diabetic，antibiotic use types and mechanical ventilation were the independent risk factors of producing ESBLs of Pneumonia klebsiella bacteria resulted to bloodstream infection.Conclusion All of hospital stays，diabetic，combined use of antibiotics and mechanical ventilation can increase the bloodstream infection probability of producing ESBLs of Pneumonia klebsiella bacteria，and producing ESBLs of Pneumonia klebsiella bacteria has highest drug resistance to ampicillin and most sensitive to imipenem.In clinical application，the treatment plan should be guided by the results of drug sensitivity. 2016 Vol. 23 (21): 37-39 [Abstract] ( 148 ) HTML (36 KB)  PDF  (0 KB)  ( 3 ) 40 Clinical study of febuxostat in the treatment of gout patients combined w ith hyperuricem ia TANG Yan-hua;JIANGMin;LIU Ling;LIU Ju Objective To explore the clinical efficacy of febuxostat in the treatment of gout patients with hyperuricemia. M ethods 50 cases of gout combined with hyperuricemia from March 2014 to September in our hospital were selected and randomly divided into the observation group and the control group，25 cases in each group.The observation group was treated with febuxostat，the control group was treated with allopurinol.The level of blood uric acid between the two groups before and after treatment was compared and the numbers of serum uric acid level less than 360μmol/L patients after treatment of the two groups was recorded.Resu lts The level of serum uric acid after treatment for 24 weeks in the two groups was lower than that before treatment，the level of serum uric acid after treatment in the observation group was lower than the control group after treatment，with significant difference（P＜0.05）.There was no significant difference in the the numbers of serum uric acid level less than 360μmol/L patients after treatment between the two groups（P＞0.05）.Conclusion The clinical effect of febuxostat in the treatment of gout patients with hyperuricemia is significant，it isworthy of clinical promotion and application. 2016 Vol. 23 (21): 40-42 [Abstract] ( 149 ) HTML (38 KB)  PDF  (0 KB)  ( 23 ) 43 Lung protective effect of rem ote ischem ic preconditioning on totally thoracoscopic cardiac surgery w ith cardiopulmonary bypass YANG Xiao-han;YU Hong-tao;ZHANG Rui;LIYa Objective To investigate the effects of remote ischemic preconditioning（RIPC）by direct femoral artery occlusion on lung function of patients undergoing totally thoracoscopic cardiac surgery with cardiopulmonary bypass（CPB）. M ethods 60 patientswith congenital heart disease underwent thoracoscopic cardiac surgery with CPB from March 2015 to May 2016 were selected and divided into the research group（group R）and the control group（group C），30 cases in each group.After the femoral artery and vein were dissociated，group C was established CPB through the intubation directly.Group R was clamped and closed femoral artery 3 min，then open 3 min，After three cycles，the samemethod in the group Cwasused to establish CPB.Through three hole shape incision at the right chestwall，that each was 1.5 to 2.0 cm long in the third，fourth and sixth intercostals surgical field was revealed totally by thoracoscope to complete the operation.The radial artery blood was collected after tracheal intubation for 5min（T0），after cessation of CPB for 2 hours（T1），after cessation of CPB 12 hours（T2）and after cessation of CPB 24 hours（T3）.Oxygenation index was recorded by blood gas analysis.The receptor of advanced glycation end-products（RAGE）level was detected by enzyme linked immunosorbent assay（ELISA）.Results 60 patientswere all cured.Therewas no significant difference in themechanical ventilation time between the two groups（P＞0.05）.There was no significant difference in oxygenation index between the two groups in T0point（P＞0.05）.The oxygenation index of the two groups of T1-T3were all decreased.The oxygenation index of group R in T1-T3pointswas higher than that of group C at the same time，with significant difference（P＜0.05）.There was no significant difference in the level of RAGE between the two groups in T0point（P＞0.05）.The level of plasma RAGE were increased in the two groups in T1-T3points.The level of plasma RAGE of group R in T1-T3pointswas lower than that of group C at the same time，with significant difference（P＜0.05）.Conclusion RIPC by femoral artery occlusion can decrease the level of RAGE in patients underwent thoracoscopic cardiac surgery with CPB and has lung protective effects. 2016 Vol. 23 (21): 43-45转49 [Abstract] ( 116 ) HTML (41 KB)  PDF  (0 KB)  ( 38 ) 46 Observation of the curative effect of laparoscopic m inimally invasive lithotripsy in the treatment of liver and gallbladder stones HUANG Shi-dong Objective To explore the clinical effect of laparoscopic minimally invasive lithotripsy in the treatment for liver and gallbladder stones.M ethods 140 patients with liver and gallbladder stones from October 2013 to November 2015 in our hospital were selected and randomly divided into the abdominal group and the routine group，70 cases in each group.The routine group was given open lithotripsy treatment，the abdominal group was given laparoscopicminimally invasive lithotripsy treatment.The visual analogue scale（VAS）was used to assess the degree of pain，the length of hospital stay，surgery time，the time of T tube pulled out，intestinal function recovery time，intraoperative bleeding volume，the incidence rate of postoperative stones from the net and complication incidence，the pain situation before operation，1 day after operation，3 days after operation，5 days after operation in the two groupswas statistical analyzed.Results The length of hospital stay and recovery time of bowel function in the abdominal group was shorter than that in the routine group，the amount of blood loss in the abdominal group was less than that in the routine group，with significant difference（P＜0.05）.The T tube extubation time in the abdominal group was longer than that in the routine group，with significant difference（P＜0.05）.The VAS score after operation for 1，3，5 days in the abdominal group was lower than that in the conventional group，with significant difference（P＜0.05）.The rate of stone net in the abdominal group was higher than that in the routine group，with significant difference（P＜0.05）.The incidence rate of complication and reoperation rate in the abdominal group wasy lower than that in the routine group，with significant difference（P＜0.05）.Conclusion Laparoscopic minimally invasive lithotripsy treatment can effectively reduce the stones in patients with liver and gallbladder stones in the process ofwound，it can reduce the pain of patients，promote patients recovery and reduce complications，it has better curative effect and security，which isworthy of clinical promotion and application. 2016 Vol. 23 (21): 46-49 [Abstract] ( 137 ) HTML (41 KB)  PDF  (0 KB)  ( 27 ) 50 Study on the app lication value of percutaneous dilational tracheostom y on the rescue of patientsw ith severe cerebrovascular accident LIBao-jia;MOQuan;SHIGang-ji;LIANGCai-gan;LIN Zi-tong;TAN Da-an Objective To explore the application value of percutaneous dilational tracheostomy（PDT）on the rescue of patientswith severe cerebrovascular accident.Methods Patientswith severe cerebrovascular accident treated in our hospital from June 2013 to December 2015 were selected as the research object.According to the way of tracheotomy，they were divided into percutaneous dilational tracheostomy（PDT group，50 cases）and conventional open tracheotomy group（OT group，55 cases）.The common conditions，NIHSS score before and after treatment，blood gas and biochemical indicators and the postoperative complications in the two groups were compared.Resu lts The operation time and healing time of PDT group were shorter than those of OT group，the size of incision was smaller than that of OT group，and the amount of intraoperative bleedingwas less than that of OT group，with statistical difference（P＜0.01）.There was no significant difference in NIHSS scores between the two groups before treatment（P＞0.05）.While after the rescue，the NIHSS scores of the two groupswere lower than those before treatment（P＜0.01），and the PDT group decreasedmore significantly（P＜0.01）.After rescue，the levels of SpO2and pH of the two groups were increased，and the levels of PCO2，lactate，ALT，BUN and Scr were all decreased，which weremore obvious in PDT group（P＜0.05）.The incidence rate of postoperative bleeding，subcutaneous emphysema in PDT group was significantly lower than those in OT group（P＜0.05）.But therewas no significant difference in the incidence rate of incision infection，tube prolapse and esophageal injury of the two groups（P＞0.05）.Conclusion PDT can significantly reduce the incidence of complications of tracheotomy，and has good clinical value. 2016 Vol. 23 (21): 50-53 [Abstract] ( 128 ) HTML (45 KB)  PDF  (0 KB)  ( 33 ) 54 Analysis on clinical characteristics and acute prognosis of patients w ith craniocerebral injury com p licated w ith intracranial infection LIJian-hua;WU Yi-yi;REN Zhen-chao Objective To investigate the clinical characteristics and factors of acute prognosis in traumatic brain injury patientswith intracranial infection.M ethods The clinical data of 245 patientswith traumatic brain injury in our hospital from April 2013 to October 2015 were employed and retrospectively analyzed.The clinicalmanifestations in intracranial infection patients were collected，and analyzed with chi square test of single factor analysis to find the risk factors of intracranial infection，in which，the significant ones were deal with logistic regression analysis.Results Among of the 245 patients，42 cases（17.1%）occurred with intracranial infection，in which clinical features for persistent head of pain were 37 cases（88.1%），headache with vomiting were 30 cases（71.4%），irregular fever were 35 cases（83.3%），.Clinical characteristics included obviousmeningeal irritation and nerve injury of optic nerve，oculomotor nerve，auditory nerve.Operative time，preoperative GCSscore less than 8 points，open craniocerebral injury，surgical site on the screen，drainage tube indwelling timemore than 7 days，leakage of cerebrospinal，diabetesmellitus etc.were for risk factors of intracranial infection related，in which，leakage of cerebrospinal fluid could bring the highest risk（OR value=7.17）.Therewas no significant relationship between sex，age，preoperative use of antibiotics and the occurrence of intracranial infection（P＞0.05）.Conclusion Prevented the intracranial infection according to the risk factors in the early stage.Paid close attention to the clinicalmanifestations of patients，to detect the patientswith intracranial infection and given treatment as early. 2016 Vol. 23 (21): 54-56转59 [Abstract] ( 129 ) HTML (38 KB)  PDF  (0 KB)  ( 36 ) 57 Analysis on risk factors of aspirin resistance in patients w ith acute cerebral infarction ZHANG Liang;ZENG Fan-yu;WEN Zi-yin Objective To systematically study relevant influence factors of aspirin resistance（AR）phenomenon in patients with acute cerebral infarction.M ethods Clinical data about 150 patients with acute cerebral infarction entering our hospital from December 2013 to December 2015 were selected for retrospective study.With the aid of thrombelastogram，wemeasured the blood platelet inhibition ratio in the induction pathway of patients′arachidonic acid（ASR）.AR meant that the blood platelet inhibition ratio was smaller than or equal to 20%；aspirin semi-resistance（ASR）meant that the blood platelet inhibition ratiowas between 20%and 50%；aspirin sensitivity（AS）meant that the blood platelet inhibition ratio was greater than 50%.By combining with the above standards，the above 150 patients were divided into different groups.Based on analysis of AR occurrence rate，characteristic differences among various groups were analyzed. Moreover，relevant risk factors of AR and ASR were summarized.Results Among patients of this group，the occurrence rate of AR was 34.0%（51/150）and the occurrence rate of ASR was 19.3%（29/150）.The high-sensitivity C-reactive protein（hs-CRP）level of AR+ASR group was obviously higher than that of ASgroup，and the difference presented statistical significance（P＜0.05）.According to Logistic regression analysis，risk factors of AR and ASR included blood platelet count and hs-CRP level.Conclusion By directing at patients with acute cerebral infarction，risk factors of AR include blood platelet count and inflammatory conditions.There is a need to regularly examine patients′blood routine and laboratory indexes，and to timely adjust clinicalmedication schemes. 2016 Vol. 23 (21): 57-59 [Abstract] ( 119 ) HTML (33 KB)  PDF  (0 KB)  ( 10 ) 60 App lication and effect evaluation of interventional em bolization combining with hysteroscopic surgery on cesarean scar pregnancy MAO Hong-yan;HUANG Xiao-hao;CHEN Bing-xiang Objective To analyze the application effect of interventional embolization combining with hysteroscopic surgery on cesarean scar pregnancy（CSP）.Methods By a random number table，24 patients with CSP admitted into our hospital from November 2014 to December 2015 were selected as research objects and evenly divided into control group and observation group.In the control group，regular therapy was used，while in the observation group，interventional embolization combining with hysteroscopic surgery was adopted.The therapeutic effect in two groups was observed and statistically analyzed.Resu lts In the observation group，the total therapeutic effective rate，satisfaction，amount of bleeding，time of bloodβ-HCG decreasing to be normal，and hospital stay were all superior to those in the control group，with a statistical differences（P＜0.05）.Conclusion For patients with CSP，application of interventional embolization with hysteroscopic surgery has a higher safety and reliability.It can reduce the amount of bleeding and decrease the incidence of complications，thereby better keep healthy for patients in a higher application value. 2016 Vol. 23 (21): 60-62 [Abstract] ( 115 ) HTML (38 KB)  PDF  (0 KB)  ( 12 ) 63 Clinical analysis of m ild hypothcrm ia in the treatment pediatric patients w ith severe hand-foot-and-mouth diseases JIAN Qing-yong Objective To explore the clinical application value of mild hypothcrmia in severe hand-foot-and-mouth diseases.Methods From March 2011 to March 2015，51 pediatric patientswith severe hand-foot-and-mouth diseases in pediatric intensive care unit（PICU）in our hospital treated with mild hypothcrmia were selected asmild hypothcrmia group，52 pediatric patients with severe hand-foot-and-mouth diseases from March 2009 to March 2015 who were not provided withmild hypothcrmiawas classified into control group.In two groups，comprehensive therapies including conventionalmechanical ventilation，mannitol for decrease of intracranial pressure，methylprednisolone and gamma globulin for immune regulation，circulatory support，ribavirin for anti-virus and sedation were provided.Rectal temperature after 2 h，time of heart rate within 160/min，time of systolic blood pressure in the normal range，incidence of pulmonary hemorrhage and mortality rate were compared in two groups.Results Rectal temperature after 2 h，time of heart rate within 160/min and time of systolic blood pressure in 80-110 mmHg in themild hypothcrmia group had obvious advantage than that in the control group respectively.Incidence of pulmonary hemorrhage in the mild hypothcrmia group was 0.00%，with 9.62%in the control group，at the fourth stage of the disease，mortality rate in the mild hypothermia group was 25.00%，with 7.84%in the control group（both P＜0.05）.Conclusion Mild hypothcrmia has great advantages on temperature dropping，heart rate decreasing and circulation improving etc.in severe hand-foot-and-mouth diseases，which is worthy of further promotion and application in clinic. 2016 Vol. 23 (21): 63-65 [Abstract] ( 133 ) HTML (34 KB)  PDF  (0 KB)  ( 9 ) 66 Practice research of critical neonatal emergency transport network in Jieyang district HUANG Xiang;LIN Chuang-ting;HUANG Hui-ting;ZHAN Chen-hong;LIN Xiao-ying Objective To carry out practice research of critical neonatal emergency transport network in Jieyang district in order to provide clinical reference.M ethods From July 2013 to April 2016，1160 critical neonates in Jieyang district were selected as research objects.The neonatal statistical distribution of disease entities and conditions after transportation in different time in Jieyang districtwere analyzed.Results The number proportion of critical transported neonates in our hospital was high with 19.14%（229/1160）from July to December in 2015，there was a great difference compared with 11.55%（134/1160）from January to April in 2016（P＜0.05）.Among statistical distribution of disease entities in emergency transport，pneumonia took themajority，95 cases from January to June in 2015，accounting for 42.79%（95/222），which was displayed a statistical difference compared with 23.88%（32/134）from January to April in 2016（P＜0.05）. Besides，during transportation，2 critical neonateswere dead due to pneumorrhagia and suffocation.After safely transported into the higher-level hospital，most of neonates were rescued，and only one baby was dead.Conclusion Critical neonatal emergency transport network in Jieyang district has a certain effect，and can effectively improve survival rate of critical neonates and decreasemortality，which isworthy of application and promotion. 2016 Vol. 23 (21): 66-68 [Abstract] ( 128 ) HTML (40 KB)  PDF  (0 KB)  ( 34 ) 69 Clinical effects observation ofmedical abortion and induced abortion CAO Yu-qin Objective To observe and compare the clinical effects ofmedical abortion and induced abortion.M ethods 200 early pregnantwomen who required to terminate pregnancy due to accidental pregnancy in the gynecological clinic in our center from January 2014 to October 2015 were selected.According to the informed consent principle，they were random ly assigned to two groups，with 100 women in themedical abortion group and another 100 women in the induced abortion group.Medical abortion group was given mifepristone combined with misoprostol for medical abortion，and the induced abortion group was given vacuum aspiration for induced abortion.Complete abortion rate，incomplete abortion rate，abortion failure rate，adverse effects，amount of vaginal bleeding，bleeding time and patients′satisfaction rate after surgery were observed in two groups，and clinical effects were compared and analyzed between two groups.Results Complete abortion rate，incomplete abortion rate and failure rate in the induced abortion group was 98%，2%and 0% respectively，with 81%，17%，and 2%respectively in the medical abortion group，complete abortion rate in the induced abortion group was significantly higher than that in the medical abortion group.Number of patients with levelⅡand levelⅢpain in the induced abortion group accounted for 59%，with 32%in themedical abortion group，pain degree in the induced abortion group was more severe than that in the medical abortion group.The incidence rate of induced abortion syndrome in the induced abortion group with 8%was higher than 1%in the medical abortion group.The bleeding time in the induced abortion group was shorter than that in the medical abortion group，and the amount of bleeding in the induced abortion group was lower than that in the medical abortion group.The rate of satisfaction towards induced abortion in the induced abortion group with 75%was lower than 84%in themedical abortion group. Conclusion Medical abortion and induced abortion have their own upsides and downsides.Patients′individual conditions should be taken as basis in clinical practices，and appropriate abortionmethod should be selected. 2016 Vol. 23 (21): 69-71 [Abstract] ( 109 ) HTML (41 KB)  PDF  (0 KB)  ( 39 ) 72 Risk factors analysis of multidrug-resistant organism s infection in newborns LI Song ;LUO Ling Objective To investigate risk factors and prevention measures in newborns with multidrug-resistant organisms（MDROs）infection.Methods A retrospective analysis wasmade on clinical data of 63 newborns with MDROs in NICU from January 2015 to January 2016，and 63 non-MDROs newbornswere choose as control group，risk factorswere analyzed by one-way ANOVA and logistic regress statistic.Resu lts one-way ANOVA analysis shew that gestational age，average hospitalization time（＞1 week），antibiotic therapy，tracheal intubation，PICC，gastric tube insertion，total parenteral nutrition were risk factors of MDROs，then Logistic regress shew that antibiotic therapy and average hospitalization time were independent risk factors.Conclusion Frequent antibiotic therapy and long-term hospitalization can cause MDROs infection，in which mechanisms include the SOS pathway and acquisition of resistance genes by HGT.Therefore，shortening the long-term hospitalization and reducing frequency of antibiotic therapy are the main measures to prevent the MDROs infection. 2016 Vol. 23 (21): 72-74转77 [Abstract] ( 142 ) HTML (37 KB)  PDF  (0 KB)  ( 17 ) 75 Clinical com parison of different delivery methods for uterine scar pregnancy ZENG Xiao-mei;CHEN Hui-hua;LUO Yao Objective To analyze the clinical effect of different delivery methods of scar uterus.Methods 120 cases of uterine scar pregnancy in our department of obstetrics from June 2013 to January 2015 were selected and divided into vaginal delivery group and cesarean section group according to the different deliverymode，with 60 cases in each group，and 50 cases of non scar uterus vaginal delivery women were as non scar uterus vaginal delivery group.Delivery ofmaternal and neonatal Apgar score were compared in two groups.Results In 120 patients with cesarean scar pregnancy maternal，48 cases elected cesarean section and 72 cases were lead to trial.12 cases in 72 cases were taken emergency cesarean section，and a total of 60 cases of vaginal delivery was successful，and trial production success rate was 83.33%（60/72）.In scar uterus vaginal delivery group and cesarean section group，the amount of bleeding was respectively（212.57±25.88）m l and（398.67±33.43）m l，the length of hospital stay was respectively（3.47±0.58）d and（5.99±0.61）d，puerperal disease incidence rate with 6.67%and 26.67%，all of the above resultswere statistically significant（P＜0.05）and neonatal Apgar scores of two groupswere no significant difference（P＞0.05）；In scar uterus vaginal delivery group and non scar uterus vaginal delivery group，amount of bleeding was respectively（212.57±25.88）ml and（78.4±13.48）ml，hospitalized days was respectively（3.47±0.58）d and（3.37±0.46）d（P＞0.05），puerperal disease incidence rates was respectively 6.67%and 6.00%（P＞0.05），neonatal Apgar scores of two groups were no significant difference（P＞0.05）. Conclusion Uterine scar pregnancy in maternal condition permits，the vaginal delivery chosen can significantly reduce the amount of bleeding，hospitalization time and puerperal disease incidence，but neonatal Apgar scores has nomore significantly effect. 2016 Vol. 23 (21): 75-77 [Abstract] ( 127 ) HTML (31 KB)  PDF  (0 KB)  ( 7 ) 78 The correlation analysis of thyroid dysfunction and body mass index in late pregnancy WANG Zhi-jian;WU Yun-yun;LU Xin-mei Objective To analyze the correlation of thyroid dysfunction and body mass index in late pregnancy.Methods 274 cases euthyroid（control group），97 cases clinical hypothyroidism（hypothyroidism group），160 cases hypothyroxinemia（hypothyroxinemia group）and 192 cases subclinical hypothyroidism（subclinical hypothyroidism group）pregnant women were recruited in our hospital from January and December 2015.The concentrations of FT3，FT4，TSH and BMI were researched.Results In hypothyroidism group，BMI and TSH were significantly higher than those in the control group（P＜0.05），FT3 and FT4 were significantly lower than those in the control group；In hypothyroxinemia group，BMI were significantly higher than that in the control group，TSH，FT3 and FT4 were significantly lower than those in the control group；There were no difference in BMI，FT3 and FT4 between subclinical hypothyroidism group and the control group，but TSH was significantly higher in subclinical hypothyroidism group；In four groups，FT3 was positively associated with BMI，FT4 was negatively associated with BMI，but relations between TSH and BMIwas not statistically significant. Conclusion High BMI during in late pregnancy is more liable to develop hypothyroxinemia and clinical hypothyroidism，but the detailed mechanism need to be studied further. 2016 Vol. 23 (21): 78-81 [Abstract] ( 124 ) HTML (46 KB)  PDF  (0 KB)  ( 33 ) 82 Clinical analysis on repeated cesarean section by abdom inal transverse incision CAIYu-qing Objective To observe and analyze the influence of abdominal transverse incision and longitudinal incision on repeated cesarean section，and to gain experience of choosing the optimal surgical option for patients.M ethods 200 patients with repeated cesarean section treated in our hospital from January 2010 to January 2016 were selected and divided based on either abdominal transverse incision or longitudinal incision of the first cesarean section into two groups，each group with 100 cases，the patientswere given the second cesarean section on the basis of the original section.The operation time，blood loss during operation，time of delivery，Apgar scores of newborns，incidence rate of pelvic adhesion，incision infection and healing conditions were observed and compared between two groups.Results The delivery time［（13±6）min］and operation time［（63±25）min］in the longitudinal incision group were significantly lower than those in the transverse incision group［（17±8）min and（90±24）min］（t=2.284，5.059，P＜0.05）.The incidence rate of pelvic adhesion was 58%in the transverse incision group，significantly higher than 22%in the longitudinal incision group（χ2=9.436，P＜0.05）.Conclusion For patientswith possibility of repeated cesarean section，longitudinal incision may be preferred in first cesarean section to facilitate the conduction and postoperative rehabilitation of the second one. 2016 Vol. 23 (21): 82-84 [Abstract] ( 104 ) HTML (36 KB)  PDF  (0 KB)  ( 39 ) 85 Clinical analysis of 3 cases of pregnancy w ith rupture of uterine horns ZHANG Ling-ling;DINGGui-chun;RENWei-juan Objective To investigate the causes，clinical features and preventivemeasures of the rupture of uterine horns in pregnancy.M ethods The clinical data of 3 cases of pregnancy with rupture of uterine horns who were treated in Yangzhou Maternal and Child Health Care Hospital from October 2010 to January 2015 were analyzed retrospectively. Results Themain cause of the rupture of the uterine horns in pregnancy was uterine horn pregnancy and the surgical history of uterine horns.All three caseswere cured and discharged from the hospital.Conclusion the rupture of uterine horns in pregnancy is a severe disease.Multiplemeasures can be taken to benefit the treatment of the disease，including improvement of laparoscopic surgery skills，attention to postoperative contraception time and embryo implantation site of early ultrasound examining，strengthened monitoring of high-risk pregnancy and early diagnosis. 2016 Vol. 23 (21): 85-87 [Abstract] ( 120 ) HTML (40 KB)  PDF  (0 KB)  ( 21 ) 88 Analysis artificial menstruation cycle regulating method in the treatment of incomplete abortion LIU Hong-yan Objective To observe the clinical effect of artificialmenstrual cycle regulating method in the treatment of incomplete abortion and provide a new treatment for incomplete abortion，especially for incomplete abortion with a small amount of tissue residues.Methods 260 cases of clinically diagnosed incomplete abortion patients from January 2014 to March 2016 in our hospital were selected as research subjects and random ly divided into experimental group and control group，with 130 cases in each group.Patients in the control group were used curettage treatment，while patients in the experimental group were used progynova and progesterone treatment，and the clinical efficacy of artificialmenstruation cycle regulation in treatment of patients with incomplete abortion was conopared.Results The duration of vaginal bleeding and menstruation recovery in the experimental group were significantly shorter than those in the control group（P＜0.05），and the vaginal bleeding volume was less than that in the control group（P＜0.05）；After the 7thand 14thd treatment，bloodβ-hCG levels in the experimental group were significantly lower than those in the control group（P＜0.05）；The levels of PSV and PDV in the experimental group were significantly lower than those in the control group，while the levels of RI and PIwere significantly higher，PSV，PDV，RI，PI indicators in the experimental group were significant difference than those in the control group（P＜0.05）.The incidence rates of pelvic inflammation，intrauterine adhesions，nausea and vomiting in the experimental group were significantly lower than those in the control group（P＜0.05）.Conclusion The effect of artificialmenstrual cycle regulation applied in incomplete abortion is significant and highly safe.It can shorten the duration of vaginal bleeding time and menstruation recovery reduce the vaginal bleeding volume.The clinical value is significant and it isworth attention and promotion. 2016 Vol. 23 (21): 88-90 [Abstract] ( 148 ) HTML (45 KB)  PDF  (0 KB)  ( 20 ) 91 differential diagnosis value of two-dimensional ultrasound and Dopp ler ultrasound in breastmass ZOU Liang-ying;LAIJi-an;LIAO Yuan-yuan;ZENG Xiao-ying;CHENWei-hua Objective To investigate the value of two-dimensional ultrasound and Doppler ultrasound in the differential diagnosis of breastmasses.Methods Altogether 400 patients with breastmasses treated in our hospital from January 2013 to December 2015 were selected as research object，all patients were divided into two-Dimensional ultrasound group and Doppler ultrasound group according to the different diagnosismethods，two-dimensional ultrasonography and color Doppler ultrasonography were adopted respectively.Pathological diagnosis results were taken as the gold standard to determine sensitivity and specificity of two-dimensional ultrasound and Doppler ultrasound in the diagnosis ofmalignant breastmasses，positive rate，misdiagnosis rate and missed diagnosis rate were compared between two groups.Results Among 400 cases of breastmasses，133 cases were pathologically diagnosed as malignant tumors，accounting for 33.25%；267 caseswere diagnosed as benign tumors，accounting for 66.75%.The diagnostic sensitivity and specificity of two-dimensional ultrasound group in breastmalignant tumorswas 94.74%and 98.50%respectively，the diagnostic sensitivity and specificity of Doppler ultrasound group in breastmalignant tumors was 91.73%and 98.88%respectively. Peak systolic velocity（Vmax），pulsatility index（PI）and resistive index（RI）levels of Doppler ultrasonography in diagnosis of benign masses were lower than those ofmalignantmasses［（12.4±4.1）cm/s vs（28.1±5.4）cm/s，（1.1±0.1）vs（1.8± 0.2），（0.54±0.08）vs（0.81±0.10），P＜0.05］.There was no statistically significant difference between the positive rate，misdiagnosis rate and missed diagnosis rate of two groups（P＞0.05）in the diagnosis of malignant breastmass.Conclusion Two-dimensional ultrasound and Doppler ultrasound demonstrate its features of high sensitivity and specificity，and can be used effectively in the differential diagnosis of benign andmalignant breastmass through ultrasonography and blood flow characteristics. 2016 Vol. 23 (21): 91-93转102 [Abstract] ( 103 ) HTML (41 KB)  PDF  (0 KB)  ( 4 ) 94 Application of transvaginal three-dimentional ultrasonography in the diagnosis of hydrosalpinx MA Liang-di Objective To explore the clinical value of transvaginal three-dimentional ultrasonography in the diagnosis of patientswith hydrosalpinx.M ethods From January 2012 to December 2015，90 patientswith hydrosalpinxin in our hospitalwere selected for grouping experimentswith 30 patients in each group.In groupⅠ，ⅡandⅢ，traditional transabdominal，transvaginal two-dimentional and transvaginal three-dimentional ultrasonographies were implemented in turn. The Doppler reconstruction and volume scanning were provided at the same time，The diagnosis condition of these three regimens was evaluated.Resu lts 90 patients were testified by radiography，surgery and pathology，among them，38 cases with hydrosalpinx in one side，and the restwith bilateral hydrosalpinx.After ultrasonic testing，there were 29 cases detected in groupⅢ，and diagnostic accordance ratewas96.7%，much higher than 60.0%in groupⅠand 73.3%in groupⅡ，with a statistical difference（P＜0.05）.Comparison of diagnostic accordance rate between groupⅠand groupⅡ，and the difference had no statistical significance（P＞0.05）.Conclusion Transvaginal three-dimentional ultrasound is simple and safe in performance and can directly reflect inner spatial structure，and accurately differentiate the relationship between salpinx and peripheral viscera aswell as the charact of hydrops in the examination of hydrosalpinx，which plays an important significance on early detection of disease and guidance of clinical treatment and is worthy of promotion in clinic. 2016 Vol. 23 (21): 94-96 [Abstract] ( 126 ) HTML (36 KB)  PDF  (0 KB)  ( 27 ) 97 Diagnostic value of ultrasound elastography combined with PET/CT in thyroid carcinoma YANG Jun-mei;HUANG Jian-yi;MA Xiao-qin Objective To study the value of ultrasound elastography imaging combined with positron emission tomography（PET）/X-ray computed tomography（CT）in the diagnosis of thyroid carcinoma.M ethods 76 cases patients with thyroid cancer diagnosed in our hospital from August 2014 to August 2015 had 93 thyroid nodules.All patients were detected by ultrasonic elastography（UE）and PET/CT before operation，all nodules were verified by pathology after operation.Diagnostic results of UE and UE combined with PET/CT，and sensitivity，specificity and accuracy of the two diagnostic methods were compared.Resu lts 93 thyroid nodules，in which had 39 malignant nodules and 54 benign nodules.The specificity and accuracy for UE+PET/CT joint diagnosis were higher than UE diagnosis［94.44%vs 81.48%，%94.62 vs 84.95%］，with a significant difference（P＜0.05）.Conclusion UE and PET/CT in the diagnosis of benign and malignant thyroid tumor have a higher diagnosis value，two diagnostic methods used in combination，can effectively improve the diagnosis accuracy of thyroid cancer，have positive significance for the explicit treatment and worth of clinical promotion. 2016 Vol. 23 (21): 97-99 [Abstract] ( 120 ) HTML (35 KB)  PDF  (0 KB)  ( 41 ) 100 Result analysis on acoustic radiation force im pulse in measurement of different sites of kidney WANG Hui-fen;ZHANG Zhou-long;LIXin Objective To discuss the difference of acoustic radiation force impulse（ARFI）in measurement of different sites of kidney by an approach perpendicular to renal capsule.M ethods 116 kidneys of 58 healthy volunteers examined in our hospital from March 2015 to January 2016 were given VTQ measurement of the cortex，medulla and sinus of kidney at upper，middle lower poles by an approach perpendicular to the renal capsule.The results were analyzed. Results By an approach perpendicular to the renal capsule，the variance analysis on SWV values of cortex，medulla and sinus of kidney at upper，middle and lower poles showed no significant difference（P＞0.05）.Conclusion The selection of measurement sites has little impacton the result of ARFI. 2016 Vol. 23 (21): 100-102 [Abstract] ( 124 ) HTML (32 KB)  PDF  (0 KB)  ( 35 ) 103 Clinical value of the ultrasonic cardiogram in diagnosis of aortic valve calcification and aortic valve stenosis in patientsw ith diabetic JIN Fen-fen Objective To explore the clinical value of ultrasonic cardiogram in diagnosis of aortic valve calcification and aortic value stenosis in patientswith diabetic.M ethods 60 patientswith diabetes treated in our hospital from May 2013 to April 2016 were selected as observation group，60 cases of healthy volunteers（without Hypertension，diabetes）in medical center of our hospital at the same period were selected as control group.GE ViVid7 color Doppler ultrasonic diagnostic instrumentwas used to detect that patients in two groups had or not aortic valve calcification and parts of calcification.Aortic leaf area and aortic cross valve differential pressure weremeasured，stenosis degree of aortic value was evaluated.Resu lts The incidence of aortic valve calcification in the observation group was 68.3%（41/60），which was significantly higher than 28.3%（17/60）in the control group，with a significant difference（P＜0.01）.The incidence of aortic value stenosis in the observation group was 58.3%（35/60），which was significantly higher than 18.3%（11/60）in the control group，with a significant difference（P＜0.01）.Conclusio n Ultrasonic cardiogram has important clinical value for detection of the incidence of calcification and aortic valve stenosis in diabetic patients，which is of great importance for prevention and treatment of serious complications in diabetic patients. 2016 Vol. 23 (21): 103-105 [Abstract] ( 132 ) HTML (39 KB)  PDF  (0 KB)  ( 39 ) 106 Treatment efficacy ofhigh-dose ribonucleic acid for primary liver cancer WANG Jin-ling Objective To explore the treatment efficacy of RNA for primary liver cancer，while improving the life quality of the patients.Methods From August 2014 to June 2015，30 primary liver cancer patients were randomly divided into two groups.The treatment group（15 cases）were treated by high-dose RNA combined with support therapy，and the control group（15 cases）were treated by support therapy alone.The levels of alanine aminotransferase，aspartate aminotransferase，serum albumin，alpha-fetoprotein and total bilirubin were tested before and 10 days after therapy，and the symptoms of liver pain，abdominal distension，fatigue，marasmus，fever，diarrhea and other clinicalmanifestations were recorded as soon as they were observed.Resu lts After 10 days treatment，the levels of ALT，AST，ALB，AFP，and TBil of treatment group were significatly better than that of control group（P＜0.05），as well as the clinical symptoms（P＜0.05）. Conclusion High-dose RNA for injection can improve the life quality of primary liver cancer patients，and the clinical efficacy is significant，the therapy should be a reference for doctors and researchers. 2016 Vol. 23 (21): 106-108 [Abstract] ( 120 ) HTML (36 KB)  PDF  (0 KB)  ( 36 ) 109 Analysis of outpatient antibiotic prescriptions in our hospital WEIYi Objective To analyse the usage of antibacterial drugs in our hospital outpatient clinicand to evaluate its rationality，to provide guidance for antibiotics.Methods 279 174 sheets ofoutpatient prescriptions in our hospital from April 2015 to October were selected，including 28 294 prescriptions for antimicrobial agents，to count the use of antibiotics in our hospital outpatientand to analyze the rationality of using antibioticsaccording to Guidelines for Dlinical Application of Antimicrobial Agents.Resu lts 279 174 sheets of prescription was collected，in which 28 294 antimicrobial prescription was accounted for 10.13%；The frequency of use of antimicrobial agents was 29 378 times，oral antibiotics accounted for 54.11%and antimicrobial agents for injection accounted for 39.06%；The use ofcephalosporin was accounted for 43.15%and the use ofmacrocyclic lactone was accounted for 18.34%；129 sheets of prescriptions for improper use of antibioticswasaccounted for 0.439%of allprescriptions for antimicrobial agents，including inappropriate usage and dosage，no suitable solvent and inappropriate combination therapy.Conclusion The use of antimicrobial agents in our hospitalhasa very small number of unreasonable，it is reasonable in general.In order to patients′life and health，it is necessary to increase efforts to ensure the safety and rational use of antimicrobial agents and timely response deficiencies. 2016 Vol. 23 (21): 109-111转114 [Abstract] ( 99 ) HTML (41 KB)  PDF  (0 KB)  ( 40 ) 112 Clinical study of nose-nutrient spray on prevention and cure of autumnrhinitis in Alxa area in Inner Mongolia Baoerchulu;YAN Min;Narenhua;YIN Xiao-qin;BAIYan-ping Objective To observe the clinical effect of nose-nutrient spray on prevention and cure of autumn-rhinitis in Alxa area in Inner Mongolia.M ethods From July 2013 to October 2015，150 patients visited our outpatient clinics for treatmentwere selected，and random ly divided into two groups.In treatment group（n=80），nose-nutrient spray was provided，while in control group（n=70），Nasal spray with budesonide was applied.The improvement of nasal symptoms and quality of life（QOL）were observed.Follow-up visits were carried on 2 and 8 weeks after treatment.Results Observing improvement of nasal symptoms and QOL in these participants，the effective rate 2-week after treatmentwas 53.75%in the treatment group，and 57.14%in the control group，which was no statistical difference（χ2=0.174，P=0.677）.The effective rate 8-week after treatment was 73.75%in the treatment group，and control group was 54.29%.The effect in the former group was higherwith a statistical significance（χ2=5.376，P=0.02）.3 cases occurred with slight dermatitis of nasal mucosa in the treatment group，and 12 cases presented with dryness and pain of nasalmucosa in the control group.All these adverse reactions were not specially dealt and in spontaneous remission after drug discontinuance.Conclusion Nose-nutrient spray applying to prevent and cure autumn-rhinitis in Alxa area in Inner Mongolia is safe and effective. It can restore the function of skin barrier and improve dryness of nasalmucosa aswell as clinical effect especially in a long-term effect and good patient′s compliance. 2016 Vol. 23 (21): 112-114 [Abstract] ( 122 ) HTML (36 KB)  PDF  (0 KB)  ( 32 ) 115 Drug using analysis of outpatient chronic gastritis GUOQin-xiang;CHEN Dan-fen;CHENWei-peng;WU Zhao-xin Objective To analyze the drug using of outpatient chronic gastritis，and to provide theoretical basis for clinical norms and rational use.M ethods 3476 electronic prescription of outpatient chronic gastritis patients from August 2014 to December 2015 were retrospectively analyzed.Table statisticswas used for the drugs that used in the prescription.Using frequency，counting and defined daily dose system of drugswere listed and were sorted to compare and analyze.Results Chronic gastritis patients are concentrated in the age of 20～60 years old；Proton pump inhibitors were the main drug for chronic gastritis，the largest DDDs value was lansoprazole and antibiotics were mainly of clarithromycin. Conclusion Clearly grasping the drug use status quo of chronic gastritis，whch can provide guidance formore rational and standardized use of therapeutic drugs in clinical in the future. 2016 Vol. 23 (21): 115-117 [Abstract] ( 104 ) HTML (33 KB)  PDF  (0 KB)  ( 39 ) 118 Evaluation of different methods in the diagnosis of respiratory syncytial virus infection in patients with acute respiratory tract infection by throat swab and nasal swab QIN Sheng;LIUWen-kuan;YUAN Tie;LIJi-qiang;CHEN Cha;CHEN De-hui Objective To compare the detection result of throat swab and nasal swab samples from children with acute respiratory tract infection detected by differentmethods.M ethods A total of 315 children with respiratory infection were recruited from March 2011 to February 2012，both throat swabs and nasal swabs were collected.Viral nucleic acid or antigen was detected by both qPCR and virus culture method，the result was compared.Resu lts With virus culture method，the positive rate of nasal swabswas 12.1%，which was higher than 6.7%of throat swabs（P＜0.01）.However，with qPCR，the positive rate of nasal swab was 17.1%，which was higher than 6.9%of throat swabs（P＜0.01）.Moreover，for the nasal swabs and throatswabs，the positive rate of qPCR was higher than that of virus culture（P＜0.01）.Base on the outcome of respiratory syncytial virus（RSV）detected with virus culture in throat swabs，the sensitivities and specificities of nasal swabs by virus culture，nasal swabs by qPCR and throat swabs by qPCR was 57%，91%，4%and 91%，88%，94，respectively.Conclusion The detection of RSV with nasal swabs ismore sensitive than throat swabs，and qPCR is more sensitive than virus culture. 2016 Vol. 23 (21): 118-120转133 [Abstract] ( 125 ) HTML (44 KB)  PDF  (0 KB)  ( 44 ) 121 Analysis of clinical distribution and drug resistance of 264 strains of Acinetobacter baumannii LIU Yu Objective To understand the clinical distribution and drug resistance of Acinetobacter baumannii in Jinzhou Central Hospital，and to provide reference for clinical treatment of infection of Acinetobacter baumannii.Methods Bacterial identification and drug sensitivity analysiswere carried out by using VITEK-2 Compact identification system from January 2014 to December 2015，and the resultswere statistically analyzed byWHONET 5.6 software.Results264 strains of Acinetobacter baumannii were isolated from our hospital，themain source of sputum samples，a total of 212 strains accounted for 80.3%，followed by the urine of 28 strains（10.6%）.Themain distribution departments for the department of respiration（89 strains accounted for 33.7%）and intensive care unit（72 strains accounted for 27.3%），followed by the department of endocrinology（30 strains accounted for 11.4%）.Main antibacterial drug susceptibility were sensitive to cefoperazone/sulbactam was 78.7%，the sensitivity rate to ampicillin/sulbactam，piperacillin/tazobactam，imipenem and meropenem was 39.9%，33.3%，33.3%and 39.6%respectively.The sensitive rates of tobramycin，ceftazidime，cefepime，gentamicin，amikacin，ciprofloxacin and SMZ-TMPwas lower than 30.0%.Conclusion Acinetobacter baumannii clinical isolated in our hospital comesmainly from sputum specimens，mostly locate in respiratory department and intensive care unit，which to cefoperazone/sulbactam sensitive rate is the highest. 2016 Vol. 23 (21): 121-123 [Abstract] ( 116 ) HTML (40 KB)  PDF  (0 KB)  ( 19 ) 124 Change in the level of xanthine oxidase and inflammatory cytokines in gout and hyperuricem ia patients LIJia-yin;ZHANGWei Objective To investigate the changes in the level of xanthine oxidase and inflammatory cytokines in patients with gout and hyperuricemia.Methods Altogether 40 cases of acute gout patientswho were treated in the hospital from November 2010 to November 2015 were selected as Gout Group；while，another 40 cases of patientswho only showed the symptoms of elevated uric acid levelswithout acute goutwere selected as Hyperuricemia Group.The levels of xanthine oxidase，uric acid and erythrocyte sedimentation rate of all the patients were measured for calculation of inflammatory cytokines（including TNF-α，IL-1 and hs-CRP levels）and statistics of the 24-hour excretion amount of uric acid.Resu lts The serum xanthine oxidase and uric acid levels of Gout Group were significantly higher than those of Hyperuricemia Group；and the ESR was faster than that of Hyperuricemia Group（P＜0.01）；the inflammatory cytokines TNF-α，IL-1 and hs-CRP levelsof patients in GoutGroup were significantly higher than those of Hyperuricemia Group（P＜0.01），and the 24-hour excretion amount of uric acid was lower than that of Hyperuricemia Group（P＜0.05）.Conclusion Patientswith acute gout show the symptoms of significantly increased serum xanthine oxidase and uric acid levels；meanwhile，TNF-α，IL-1 and hs-CRP play an important role in the development of gout. 2016 Vol. 23 (21): 124-126 [Abstract] ( 109 ) HTML (37 KB)  PDF  (0 KB)  ( 32 ) 127 Change of PCT and hs-CRP level in patients with acute exacerbation of chronic obstructive pulmonary disease and their diagnostic value study ZHANG Yuan-man;CHEN Huai-lin;ZHANG Chun-jun Objective To explore the changes of the level of PCT and hs-CRP and diagnosis value in patientswith acute exacerbation of chronic obstructive pulmonary disease（AECOPD）.Methods 60 cases of COPD from October 2014 to May 2015 in our hospital were studied and divided into the acute exacerbation group and the stable group according to the patient′s condition，30 cases in each group.30 healthy people were selected as the control group.The PCT levelwas detected by chemiluminescencemethod for quantitative determination，the hs-CRP level was detected by rate than the scattering turbidity.The numerical level of CT and hs-CRP in each group was compared，and the AECOPD patients and the relationship of the above description was obversed.Results The level of PCT and hs-CRP in the acute exacerbation group was higher than that in the stable stage group and the control group，with significant difference（P＜0.05）.The level of PCT and hs-CRP in the stable stage group was higher than that in the control group，with significant difference（P＜0.05）.The level of PCT and hs-CRP in the AECOPD infection group was higher than that in the uninfected group，with significant difference（P＜0.05）.Conclusion PCT and hs-CRP test for diagnosis of AECOPD infection in patients has high diagnostic value，it isworthy of clinical promotion and application. 2016 Vol. 23 (21): 127-129 [Abstract] ( 129 ) HTML (37 KB)  PDF  (0 KB)  ( 10 ) 130 Clinical value of BNP and CA125 detections in the diagnosis of acute heart failure GONGChu-ping Objective To explore the clinical value of B-type natriuretic peptide（BNP）and serum carbohydrate antigen 125（CA125）in the diagnosis of acute heart failure.Methods 60 patientswith acute heart failure in our hospital from January to December 2015 were selected.According to New York Heart Association（NYHA）classification，all patients were divided into cardiac functionⅡ，Ⅲ，Ⅳgroup.Another group of 20 participants for physical examinations during the same period was selected.The level of BNP and CA125 from each group was compared.Correlation analysis was based on the values of BNP and CA125 and echocardiographic parameters.The correlation between these indexes and adverse cardiovascular events including refractory heart failure，malignant arrhythmia，cardiogenic shock，and sudden cardiac death within three-month follow-up visits aswell as re-hospitalization due to acute heart failure were observed.Resu lts In comparison with the control group，the level of BNP and CA125 in these heart failure patientswere greatly improved and were gradually increased following NYHA classification elevating，with statistical differences（P＜0.01）.The level of BNP and CA125 have negative correlationswith left ventricular ejection fraction（LVEF），these two indexes have positive correlationswith left ventricular end diastolic diameter（LVEDD），which have positive correlations with pulmonary artery pressure.After analyzing the specificity and sensitivity of BNP and CA125 in predicting the prognosis of heart failure，CA125 could better predict the prognosis in comparison with that by BNP.Conclusion The levels of BNP and CA125 are increasing in acute heart failure.CA125 can be considered as an important index on diagnosing heart failure，which plays important significance on predicting prognosis. 2016 Vol. 23 (21): 130-133 [Abstract] ( 117 ) HTML (42 KB)  PDF  (0 KB)  ( 27 ) 134 Diagnostic value of T cellenzym e-linked immuno spot tuberculosis assay in the patientsw ith tuberculosis and diabetes LIU Li-hu;WU Jun;XIONG Jun-ning Objective To evaluate the clinicalapplication of T cellenzyme-linked immuno spot tuberculosis（T-SPOT.TB）assay for diagnosis of tuberculosis with diabetes.Methods 104 cases of pulmonary tuberculosis patients in Infectious Diseases Hospital of Fuxin City in Liaoning Province between March 2014 to October 2015 were recruited，including 54 cases of pulmonary tuberculosis patients with diabetes as the experimental group，50 cases of tuberculosis combined without diabetes patients as control group.All patients using T-SPOT.TB and tuberculin skin test（TST）and sputum smear examination，and the resultswere analyzed by statistical analysis.Results The sensitivity of T-SPOT.TB（90.7%）was significantly higher than that of sputum smear and TST（24.1%，55.6%），with statistically significant difference（P＜0.01）.Conclusion T-SPOT.TB has high sensitivity in the diagnosis of pulmonary tuberculosis complicated with diabetes，it isworth to be popularized in clinic. 2016 Vol. 23 (21): 134-136转139 [Abstract] ( 135 ) HTML (45 KB)  PDF  (0 KB)  ( 32 ) 137 Expression and significant of blood vessel endothelial cellmarkers in peripheral blood of coronary arteriosclerosis patients CHEN Jing;ZHANG Lue Objective To observe the level of blood vessel endothelial cell marker expression in peripheral blood of coronary arteriosclerosis patients and to discuss the significant.M ethods 127 patients diagnosed as coronary heart disease（CAD）from February 2014 to February 2015 in our hospital was randomly selected as the CAD group and 32 healthy person with physical examination was selected as the normal control group（NC group）.The CAD group was divided into acute coronary syndrome group（ACS group，n=56）and the stable coronary angina pectoris group（SAP group，n=17）.Enzyme link immune assay method and radio immune method were used to detect the expression of ET-1，NO，CD105，CD34，6-keto-PGF1αand TXB2.Correlation with CT coronary angiography was analyzed.Results ET-1，CD105 and TXB2expression was higher in ACS and SAP group than in NC group（P＜0.05），which was higher in ACS group than in SAP group（P＜0.05）.ET-1，CD105 and TXB2expression in calcium type，fiber type and soft type were different（P＜0.05），ET-1 and TXB2in calcium type was higher than in fiber and soft type（P＜0.05），CD105 in calcium type and fiber typewas higher than in soft type（P＜0.01）.Conclusion ET-1，CD105 and TXB2are correlated with CAD and may be helpful for diagnosis and predict the prognosis. 2016 Vol. 23 (21): 137-139 [Abstract] ( 117 ) HTML (35 KB)  PDF  (0 KB)  ( 23 ) 140 Com parison of p lasma D-dim er norm al reference interval in elderly and young people ZHENG Hong-tu;LIZhen-jia;RONG Xing Objective To explore the normal reference interval of plasma D-dimer test in elderly and young people. Methods 1208 healthy peoples in our hospital from January 2015 to December were selected and divided into three groups according to the different age，the group of age less or equal to than 39 years old（381 cases），the group of age from 41 to 59 years old（416 cases），the group of agemore or equal to than 60 years old（411cases）.The level of plasma D-dimer in each group was detected.Results There was no significant difference in the level of plasma D-dimer between the group of age less or equal to than 39 years old and the group of age from 41 to 59 years old（P＞0.05）.There was significant difference in the level of plasma D-dimer between the group of age from 41 to 59 years old and the group of agemore or equal to than 60 years old（P＜0.01）.The normal reference range of the level of plasma D-dimer in the age less or equal to than 59 years old was less than 528.28μg/L，the normal reference range of the level of plasma D-dimer in the agemore or equal to than 60 years old was less than 703.70μg/L.Conclusion Plasma D-dimer level is associated with age，with the increase of age，the level of plasma D-dimer is riseing.The normal reference range of plasma D-dimer level is different between the elderly and the young people.Different age groups should be used different instruments and the appropriate reagents，the laboratory should be established its own reference range. 2016 Vol. 23 (21): 140-142 [Abstract] ( 100 ) HTML (36 KB)  PDF  (0 KB)  ( 22 ) 143 Discussion on the strategy of im proving the execution of hand hygiene management system TANG Juan;WEN Yin-hao;LIN Hui;Yi Qing-ping Hand hygiene is recognized as themost economical，themost effectivemethod to control the hospital infection.However，the hand hygiene compliance ofmedical staff is unsatisfactory in China currently.The implementation rate of hand hygiene in large and medium-sized hospitals in China is 40%to 60%.The executive power of hand hygiene management system needs to be improved.Therefore，this paper analyzed the problems existing in the current implementation of hand hygiene form the aspectsof personnel，facilities，system and culture in detail，and accordingly presented the corresponding suggestions to improve the executive power of hand hygienemanagement system，which aimed to decrease hospital infection rate，reducemedical risk and improve quality ofmedical care. 2016 Vol. 23 (21): 143-145 [Abstract] ( 123 ) HTML (37 KB)  PDF  (0 KB)  ( 32 ) 146 The influence of details management on waiting time and satisfaction of health exam ination people ZHANG Jie-yun Objective To analyze the influence of detailsmanagement on waiting time and satisfaction of health examination people.M ethods 70 health examination people from February to November 2015 in our hospitalwere selected as the research objects and were random ly divided into two groups，35 cases in each group.The control group was treated with conventionalmanagement to have health examination，and the observation group was treated with detailsmanagement on the basis of the control group.The waiting time and satisfaction of two groups of health examination people were compared.Resu lts There were medical groups of blood，urine，electrocardiogram and surgical examination waiting time of observation group was significantly shorter than that of control group，which had statistically significant difference（P＜0.05）；The satisfaction of health examination people in observation group was 97.14%，which was remarkably higher than 77.14%in control group，and the difference had statistical significance（P＜0.05）.Conclusion Detailsmanagement takes health examination people as the center in examination process and perfects the examination process according to people′s requirements，which is able to shorten the waiting time，relieve medical workers′pressure，improve the satisfaction and increasemedicalworkers′efficiency. 2016 Vol. 23 (21): 146-148 [Abstract] ( 126 ) HTML (37 KB)  PDF  (0 KB)  ( 28 ) 149 The discussion and prospect on the teaching method of Pharmacy Adm inistration course LIWei-nie;ZENG Yu;CHEN Yan-ying;Li Guo-guo The course of Pharmacy Administration has the strong political and practical characters.In order to enhance the interaction with the students and improve the teaching effect，except the traditional classroom teaching，teachers should try to explore and apply other useful teachingmethods.Several typical teachingmethodswere summarized in this paper，also a prospect for future university teaching trendswere looked forward.It is hoped that the teachers keep in step with the teaching forefront，and use a variety of teachingmethods. 2016 Vol. 23 (21): 149-151转154 [Abstract] ( 112 ) HTML (42 KB)  PDF  (0 KB)  ( 39 ) 152 The present reformational situation of thepostgraduates education w ith clinical professional degree of traditional Chinesemedicine DING Chun-li;HOU Li-hui;ZHANG Chun-lan;NIU Jing-yun;SUN Miao;LIYan The development ofmodernmedicine on postgraduate education presents higher demands and challenges，and the training pattern reform has become inevitable，while the emphasis of cultivation in graduate students education is the training ofthe innovation ability and adaptability.The hope of this article is to present a new way on postgraduate education by combing the relevant literatures. 2016 Vol. 23 (21): 152-154 [Abstract] ( 130 ) HTML (32 KB)  PDF  (0 KB)  ( 31 ) 155 1 cases of nursing for patients with ureteral and rectal endom etriosis undergoing laparoscopic surgery CUIAn-na;LIHong-ling To summarize 1 cases of nursing for patientswith ureteral and rectal endometriosis undergoing laparoscopic surgery.Through reasonable preoperative dietary guidance，skin preparation，appropriate and understandable preoperative education and postoperative guidance of various pipeline nursing and posture（both to avoid the slip line，and to the drainage liquid leads to），the prevention and nursing of complications，diet guidance and supervision，coupled with the close cooperation of patients，aswell as reasonable and effective nursing，the patients recovered and discharged. 2016 Vol. 23 (21): 155-157 [Abstract] ( 109 ) HTML (35 KB)  PDF  (0 KB)  ( 34 ) 158 1 case of thyroglossal tube papillary carcinoma and the literature review XIAO Fu-fu;LAN Xiao-lin;LUO Ke-qing;TIAN Ke-qiang;LIANG Ting;WANG Dong-mei;LIRong;ZHANG Xiang-min By observing 1 case of thyroglossal tube papillary carcinoma clinical data and pathological and review and summarization the pathological and clinical data of thyroglossal tube papillary carcinoma to explore the histogenesis and clinical treatment of thyroglossal duct carcinoma.Thyroglossal duct carcinoma histological originates from the residual thyroid tissue，the clinicalmanifestations are similar to thyroglossal duct cyst，making a definite diagnosismust be confirmed by postoperative pathology，and with good outcome.The diagnosis of thyroglossal duct carcinoma needs clearly pathology.The preferred treatment is surgery，and whether to do neck lymph node cleaning and thyroid thyroidectomy and subsequent treatment are according to particular situations. 2016 Vol. 23 (21): 158-160 [Abstract] ( 117 ) HTML (46 KB)  PDF  (0 KB)  ( 11 ) 161 Them isdiagnosis analysis from 1 case of metastatic squamous cell carcinoma originated from liver LILei;WANGChang;CHEN Hong-chun;CHEN Fei Objective This study introduced the process of misdiagnosis and share relevant experiencing in diagnosis and treatment from a case ofmetastatic squamous cell carcinoma originated from liver.M ethods This casewas diagnosed after the retrospective analysis of clinicalmedical records，preoperative tumor antigen examination，imaging examination，and postoperative pathological diagnosis result.Resu lts By analyzing，this study found that the correlations between the metastatic squamous cell carcinoma to the liver and squamous cell carcinoma antigen（SCCAg）.In addition，the focis characters of liver metastatic carcinoma from CT enhanced scan has its own regularity.Conclusion Due to the reason thatmetastatic squamous cell carcinoma originated from liver is rare in clinic，so we should pay more attention to this disease.Preoperative SCCAg，magnetic resonance imaging（MRI）scan，CT enhanced scan，gastroscopy，colonoscopy and multidisciplinary consultation are needed to diagnose the primary lesion and to reducemisdiagnosis. 2016 Vol. 23 (21): 161-163 [Abstract] ( 115 ) HTML (31 KB)  PDF  (0 KB)  ( 3 ) 164 Influence of Zusanlim assage and early drinking a little water on gastrointestinal decom pression patients after abdom inal surgery XU Xiao-li Objective To investigate the influence of Zusanlimassage and early drinking a little water on gastrointestinal decompression patients after abdominal surgery.Methods 60 cases of gastrointestinal decompression in our hospital from January 2015 to January 2016 were selected and randomly divided into the experimental group and the control group，30 cases in each group.The control group was given conventional nursing，and the experimental group were followed up after the understanding and agreement of patients and their familymembers，removed gastric tube on the first day after operation，then performed Zusanlimassage 2 times a day for 3-5 days，1 times per 4 hours drinking water and increasing day by day until the recovery of gastrointestinal function.The time of exhaust，defecation，abdominal distension disappeared，appetite recovery，hospitalization and bed time and other indicators in the two groupswas compared.Resu lts The exhaust time，the first defecation time，abdominal distension and disappearance time，appetite recovery time，length of stay and bed time in the experimental group was shorter than that in the control group，with significant difference（P＜0.01or P＜0.05）.Conclusion Zusanlimassage and drinking a little water have obvious benefits to gastrointestinal decompression patients after abdominal surgery，which can be used for reducing the recovery time of exsufflation and defecation，disappearing of abdominal distention，improvement of appetite，and postoperative hospital stay. 2016 Vol. 23 (21): 164-166 [Abstract] ( 111 ) HTML (33 KB)  PDF  (0 KB)  ( 11 ) 167 App lication effect of"holistic nursing care"in pediatric ward CHEN Li-hong;WU Xiao-feng;LIU Hai-jun Objective To explore application of"holistic nursing care"mode in pediatric clinical nursing，improve the quality of pediatric nursing.M ethods Will be taken from June 2014 to June 2015 to our hospital Pediatric patients in 200 cases，Randomly divided into control group and observation group，each of 100 cases，Control group according to the routine nursing service implementation，The observation group was given the standard"holistic nursing"service.The family members of two groups were compared.Resu lts Observation group service attitude was 97%，Health education is 93%，Puncture technique is 91%，Answer questions for 95%，Medication guidance for 93%，Inspection of infusion was 95%，Inform the attention to 89%，Basic care for 96%，Call bell response time is 95%，The responsibility of nurses is 96%，Were significantly higher than those in the control group（86%，81%，78%，84%，86%，81%，77%，89%，88%，84%），The difference between the two groups was statistically significant（P＜0.05）.Conclusion Human standard"holistic nursing care"can not only providemore high-quality nursing services for children，Regulate the behavior of nurses，Tomobilize the enthusiasm of nurses，Improve the comprehensive quality of nurses，Enhance the satisfaction of family members of patients，Reduce nursing disputes，Building a harmonious relationship between nurses and patients has an important role. 2016 Vol. 23 (21): 167-169 [Abstract] ( 129 ) HTML (36 KB)  PDF  (0 KB)  ( 2 ) 170 Nursing experience of humanistic care in selective fallopian tube recanalization ZHOU Bi-yun;LIANG Si-si;CHEN Mei-zhu;PENG Bi-wen;CHEN Yin-qin;CHEN Qiao-ya Objective To explore the application effect of humanistic caremode in selective fallopian tube recanalization on treating tubal obstruction infertility.M ethods From January 2014 to December 2014，92 patients undergone selective fallopian tube recanalization in our hospital were selected and evenly divided into observation group and control group in random.In the control group，conventional nursing was adopted，while in the observation group，onthe basis of the control group，nursing from psychology and humanistic care was added.The nursing effect in the two groups was compared.Resu lts The total nursing satisfaction in the observation group was 95.65%，and the uterine pregnancy rate was 80.4%，which weremuch higher than those in the control group，76.07%and 53.3%respectively，which were displayed statistical differences in the two groups（P＜0.05）.Conclusion Humanistic care plays an important role in patients with selective fallopian tube recanalization.It not only is beneficial for patient′s improvement of nursing satisfaction，but also increases uterine pregnancy rate，which isworthy of clinical application and promotion. 2016 Vol. 23 (21): 170-172 [Abstract] ( 136 ) HTML (39 KB)  PDF  (0 KB)  ( 13 ) 173 The effect ofmental health education to enhance capability and efficiency of the fam ily num bers to care psychiatric patients FU Ping-ping;ZHUWei-fang;WU Dong-hong;FUWen-xia;LU Xue-zhen;YANG Shu-fen Objective To explore the effect ofmental health education to enhance capability and efficiency of the family numbers to care psychiatric patients.M ethods From October 2014 to June 2015，the family members of hospitalized psychiatric patients were selected department of psychiatric in our hospital，based on whether or not to use mental health education，the family numberswere divided into observation group and control group，48 cases in each group.Zung Anxiety Rating Scale（SAS）and Self-Rating Depression Scale（SDS）were used to evaluate anxiety and depression of the patients and the family numbers after patients admitted to hospital，after intervention 1 week，2 weeks，4 weeks，8 weeks for the family numbers，and after intervention 8 weeks treatment compliance of the patients was assessed.Resu lts After intervention 4 weeks，8 weeks for the family numbers in the observation group and the control group，anxiety scores［（50.49±3.25）points，（57.21±3.49）points］［（41.79±3.40）points，（56.43±4.32）points］，depression scores［（45.95±3.85）points，（40.86±4.71）points］［（56.58±4.53）points，（56.06±4.87）points］were compared，the difference was statistically significant（P＜0.05）.After intervention 8 weeks for the family numbers in two groups，anxiety score［（48.65±4.64）points，（63.74±4.65）points］and depression score［（50.07±4.69）points，（62.13±4.58）points］were compared，the difference was statistically significant（P＜0.05）.The rate of treatment compliance（100.00%，87.50%）in two groups after intervention8 weeks，the differencewas statistically significant（P＜0.05）.Conclusion Mental health education for the family numbers of psychiatric patients could indirectly improve symptoms of anxiety and depression，and improve their treatment compliance.Mental health education could significantly enhance capability and efficiency of the family numbers to care psychiatric patients. 2016 Vol. 23 (21): 173-176 [Abstract] ( 136 ) HTML (48 KB)  PDF  (0 KB)  ( 35 ) 177 Practice of app lying quality control circle to improve safety m anagement on operating room nursing HE Lu;SHILan;HUANG Chao-yi Objective To explore the effect analysis of quality control circle（QCC）on improving the quality of operating room nursing.Methods From January 2014 to December 2015，patients undergone surgeries admitted into our hospital were selected as research objects.QCC organization was set up by nurses in the operation room from January 2015.The theme was improvement of quality on operating room nursing，and QCC was named as elite circle.According to QCC steps，activity plans including establishment of a group，investigation on the current situation，reason analysis，goal setting，implementation of the plan，and effect analysiswere drawn up.Disinfection and isolation，layout of equipment，cooperation among special departments，nursing safety，nursing service，and nursing management were summarized and analyzed.Another group of 7198 patients undergone surgeries from January to December in 2014 was selected as control group.The incidence of adverse reactions and patient′s satisfaction before and after QCC were observed.The qualified rate of nursing quality before and after QCC was statistical analyzed.Results After carrying out QCC，the incidence of nursing adverse reactionswas 23.5%，much lower than that before QCC accounting for 32.6%.The satisfaction after the activity was greatly higher than that before with statistical differences（χ2=12.986 and 4.185，P＜0.05）.After the activity，the qualified rates of picking up patients safely，nosocomial infection control，intraoperative cooperation，postoperative cooperation，and nursingmeasureswere all obviously higher than those before QCC，which were displayed statistical differences（χ2=28.347，6.472，7.385，14.494 and 17.011，P＜0.05）.Conclusion QCC can effectively improve participative management awareness of nurses，cultivate the cohesiveness of nursing group，enhance the capacities of dealing with problems by nurses，and improve the safemanagement quality of operating room nursing. 2016 Vol. 23 (21): 177-180 [Abstract] ( 117 ) HTML (43 KB)  PDF  (0 KB)  ( 24 ) 181 Application effects of HFMEA in prevention ICU unplanned extubation of tracheal intubation QIU Hong;ZHANG Jin-feng;LIU Xiao-lan;ZHU Hua-yong;LUO Jun-ping;LIU Yu-jie Objective To explore the practice effects of using HFMEA in prevention ICU unplanned extubation of tracheal intubation.Methods 474 patients who unimplemented HFMEA intubation and greater than 24 h from January 2013 to December and 547 patients who implemented HFMEA intubation and greater than 24 h from January 2014 to December were selected.For ICU tracheal intubation unplanned extubation composition team，the operation process was analyzed and the flow chartwasmade to analyze the failuremode and cause of potential risk.The RPN and incidence rate before and after ICU unplanned extubation of tracheal intubation were compared.Results After conducting，the total RPN of ICU unplanned extubation of tracheal intubation was 2357.46，obvious lower than that was 3830.08 before conducting，and the difference was statistical significance（P＜0.05）.After conducting，the incidence rate of ICU unplanned extubation of tracheal intubation was 1.687%，obvious devreased than thatwas 0.365%before conducting，and the difference was statistical significance（χ2=4.577，P＜0.05）.Conclusion Using HFMEA can prevent the incidence of unplanned extubation of tracheal intubation effectively and decreasemedical risk. 2016 Vol. 23 (21): 181-184 [Abstract] ( 135 ) HTML (39 KB)  PDF  (0 KB)  ( 14 ) 185 Application value of individualized nursing intervention in treating colpitism ycotica LUO He-ping Objective To explore the application value of individualized nursing intervention in treating colpitismycotica.Methods Clinical data of 70 colpitismycotica patientsaccepted treatment from June 2014 to June 2015 of our hospitalwere retrospective analyzed.Patientswere random divided into control group and observation group，and each group was 35 cases.Patients in control group were given routine nursing intervention，and patients in observation group were given individualized nursing intervention.The effective rate，the incidence rate of adverse effects and nursing satisfaction in two groups were compared.Results The effective rate in control group and observation group were respectively 71.4%and 94.3%，the incidence rate of adverse effectswere respectively20.0%and 5.7%，the recurrence rate were respectively25.7%and 5.7%，nursing satisfaction were respectively 82.9%and 97.1%，with statistical significance（P＜0.05）.Conclusion The effects of using individualized nursing intervention in colpitis mycotica patients are more obvious，which can decrease recurrence rate and can be application in clinical. 2016 Vol. 23 (21): 185-187 [Abstract] ( 118 ) HTML (37 KB)  PDF  (0 KB)  ( 37 ) 188 Influence of high quality nursing on postoperative complications and quality of life in patients with lung cancer LIANG Gui-xi Objective To observe the high quality nursing on postoperative complications and quality of life（QOL）in patientswith lung cancer.M ethods From January 2012 to December 2015，280 lung cancer patients undergone surgeries were selected and evenly divided into observation group and control group in random.In the control group，conventional nursing was used，while in the observation group，high quality nursing was provided.The relevant surgical indexes and KPS score and PQLI score before and after surgery in both groups were observed.Results In the observation group，SpO2after surgery was much higher than that of control group.The time of tube drawing and hospital stay weremuch shorter in comparison with those in the control group，which were displayed statistical differences（P＜0.05）.In the observation group，7 caseswere presented with complications and the incidence of complicationswas 5.00%，while in the control group，23 cases were occurred with complications，and the incidence was 16.43%.The incidence of postoperative complications in the observation group wasmuch lower than thatof control group with a statistical difference（P＜0.05）. There was no great difference in KPS score or PQLI score before surgery in the two groups（P＞0.05）.After therapy，the scores were all increased，but the increase in the observation group wasmuch more remarkable，which was displayed a statistical difference in comparison with that in the control group（P＜0.05）.Conclusion High quality nursing can decrease the incidence of postoperative complications and improve patient′s quality of life. 2016 Vol. 23 (21): 188-190 [Abstract] ( 108 ) HTML (36 KB)  PDF  (0 KB)  ( 31 ) 191 Application effects of using pain control nursing model in patients with traumatic fracture after surgery XIE Li-juan;GUO Li-ping Objective To study the rehabilitation intervention clinical effects of using pain control nursing model in patients with traumatic fracture after surgery.M ethods 90 traumatic fracture patients，accepted surgery treatment，from December 2013 to December 2015 ofour hospitalwere selected and randomly divided into control group and observation group，each group was 45 cases.Patients in control group were used postoperative rehabilitation intervention with routine fracture nursing model，and patients in observation group were used postoperative rehabilitation intervention with pain control nursingmodel.Recovery treatment effect of traumatic fracture after operation，satisfactory degree of rehabilitation interventionmodel for patientswith traumatic fracture after operation，total duration of hospitalization after operation and physiological function of fracture site was restored to normal time in two groups were compared.Resu lts The total effective rate of recovery treatment effect of traumatic fracture after operation in observation group was 91.1%，obvious better than thatwas 71.1%in control group（χ2=6.38，P＜0.05）；The satisfactory degree of rehabilitation intervention model for patientswith traumatic fracture after operation was 95.6%，obvious higher than thatwas 80.0%in control group（χ2= 5.87，P＜0.05）；The total duration of hospitalization after operation and physiological function of fracture site was restored to normal time were respectively（12.30±4.28）d and（86.45±8.32）d，obvious shorter than thatwere respectively（17.84± 6.41）d and（108.67±13.52）d in control group（t1=14.7280，t2=31.2784）.Conclusion The postoperative rehabilitation intervention effects of using pain control nursingmodel in patientswith traumatic fracture after surgery is very obvious. 2016 Vol. 23 (21): 191-193 [Abstract] ( 107 ) HTML (36 KB)  PDF  (0 KB)  ( 29 ) 194 App lication effects of humanized nursing in perioperative nursing care of patients undergoing laparoscopic radical gastrectomy for gastric cancer ZHU Lin-ping;LIN Li Objective To explore the application effects of humanized nursing in perioperative nursing care of patients undergoing laparoscopic radical gastrectomy for gastric cancer.M ethods 100 patients，conducted laparoscopic radical gastrectomy，from January 2015 to December 2015 of our hospital were selected and were random ly divided into control group and observation group，each group was 50 cases.Patients in control group were given routine perioperative nursing，and patients in observation group were given humanized nursing on the basis of routine perioperative nursing.The hospital stay，recovery time of bowel sound，anal exhaust time and the incidence of post operative complication in two groupswere observed and compared.The postoperative pain in two groups was evaluated，and the total effective rate and satisfaction degree were statistical analyzed.Results The hospital stay，recovery time of bowel sound and anal exhaust time in observation group were lower than that of control group，and the difference was statistical significance（P＜0.05）；The postoperative sensory score，emotional points，PRI total score，PPIand VAS in observation group were lower than that of control group，and the difference was statistical significance（P＜0.05）；The total effective rate，satisfaction degree and the incidence rate of post operative complication in observation group were better than that of control group，and the difference between two groups was statistical significance（P＜0.05）.Conclusion The application effects of humanistic nursing in laparoscopic radical gastrectomy perioperative nursing care are obvious，which can decrease the incidence of complications，promote the recovery of intestinal function and isworth to popularize in clinical. 2016 Vol. 23 (21): 194-196 [Abstract] ( 111 ) HTML (39 KB)  PDF  (0 KB)  ( 36 )

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