妊娠晚期甲状腺功能异常与体质量指数的相关性分析

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Abstract Objective To analyze the correlation of thyroid dysfunction and body mass index in late pregnancy.Methods 274 cases euthyroid（control group），97 cases clinical hypothyroidism（hypothyroidism group），160 cases hypothyroxinemia（hypothyroxinemia group）and 192 cases subclinical hypothyroidism（subclinical hypothyroidism group）pregnant women were recruited in our hospital from January and December 2015.The concentrations of FT3，FT4，TSH and BMI were researched.Results In hypothyroidism group，BMI and TSH were significantly higher than those in the control group（P＜0.05），FT3 and FT4 were significantly lower than those in the control group；In hypothyroxinemia group，BMI were significantly higher than that in the control group，TSH，FT3 and FT4 were significantly lower than those in the control group；There were no difference in BMI，FT3 and FT4 between subclinical hypothyroidism group and the control group，but TSH was significantly higher in subclinical hypothyroidism group；In four groups，FT3 was positively associated with BMI，FT4 was negatively associated with BMI，but relations between TSH and BMIwas not statistically significant. Conclusion High BMI during in late pregnancy is more liable to develop hypothyroxinemia and clinical hypothyroidism，but the detailed mechanism need to be studied further.

Key words： Hypothyroidism Hypothyroxinemia Subclinical hypothyroidism Bodymass index Pregnancy

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	WANG Zhi-jian
	WU Yun-yun
	LU Xin-mei

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WANG Zhi-jian,WU Yun-yun,LU Xin-mei. The correlation analysis of thyroid dysfunction and body mass index in late pregnancy[J]. 中国当代医药, 2016, 23(21): 78-81.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2016/V23/I21/78

［1］	Palma CC，Pavesi M，Nogueira VG，et al.Prevalence of thyroid dysfunction in patients with diabetes mellitus［J］. Diabetol Metab Syndr，2013，5（1）：58.
［2］	中华医学会内分泌学分会，中华医学会围产医学分会.妊娠和产后甲状腺疾病诊治指南［J］.中华内分泌代谢杂志，2012，28（5）：354-371.
［3］	Solanki A，Bansal S，Jindal S，et al.Relationship of serum thyroid stimulating hormone with body mass index in healthy adults［J］.Indian JEndocrinol Metab，2013，17（Suppl 1）：S167-S169.
［4］	Athukorala C，Rumbold AR，Willson KJ，et al.The risk of adverse pregnancy outcomes in women who are overweight or obese［J］.BMCPregnancy Childb，2010，10：56.
［5］	Nelson SM，Matthews P，Poston L.Maternal metabolism and obesity：modifiable determinants of pregnancy outcome［J］. Hum Reprod Update，2010，16（3）：255-275.
［6］	American College of Obstetricians and Gynecologists. Thyroid disease in pregnancy［J］.Obstet Gynecol，2015，125（4）：996-1005.
［7］	Nohr EA，Vaeth M，Baker JL，et al.Combined associations of prepregnancy body mass index and gestational weight gain with the outcome of pregnancy［J］.Am JClin Nutr，2008，87（6）：1750-1759.
［8］	Villamor E，Cnattingius S.Interpregnancy weight change and risk of adverse pregnancy outcomes：a population based study［J］.Lancet，2006，368（9542）：1164-1170.
［9］	Bestwick JP，John R，Maina A，et al.Thyroid stimulatinghormone and free thyroxine in pregnancy：expressing concentrations as multiples of the median（MoMs）［J］.Clin Chim Acta，2014，430：33-37.
［10］	Longhi S，Radetti G.Thyroid function and obesity［J］.JClin Res Pediatr Endocrinol，2013，5（Suppl 1）：40-44.
［11］	俞仁艳，荣灿，相俐至，等.甲状腺机能正常人体重指数与血清甲状腺激素FT3及FT3/FT4比值的相关性［J］.江苏医药，2015，41（17）：2017-2019.
［12］	Taylor PN，Richmond R，Davies N，et al.Paradoxical relationship between bodymass index and thyroid hormone levels：a study using mendelian randomization［J］.J Clin Endocrinol Metab，2016，101（2）：730-738.
［13］	Marzullo P，Minocci A，Tagliaferri MA，et al.Investigations of thyroid hormones and antibodies in obesity：leptin levels are associated with thyroid autoimmunity independent of bioanthropometric，hormonal，and weight-related determinants［J］.J Clin Endocrinol Metab，2010，95（8）：3965-3972.
［14］	Ambrosi B，Masserini B，Iorio L，et al.Relationship of thyroid function with body mass index and insulinresistance in euthyroid obese subjects［J］.J Endocrinol Invest，2010，33（9）：640-643.
［23］	Nyrnes A，Jorde R，Sundsfjord J.Serum TSH is positively associated with BMI［J］.Int JObes（Lond），2006，30（1）：100-105.
［15］	Marwaha RK，Tandon N，Garg MK，et al.Impact of body mass index on thyroid functions in Indian children［J］.Clin Endocrinol（Oxf），2013，79（3）：424-428.
［16］	Pop VJ，Biondi B，Wijnen HA，et al.Maternal thyroid parameters，body mass index and subsequent weight gain during pregnancy in healthy euthyroid women［J］.Clin Endocrinol（Oxf），2013，79（4）：577-583.
［17］	Gowachirapant S，Melse-Boonstra A，Winichagoon P，et a l. Overweight increases risk of first trimester hypothyroxinaemia in iodine-deficient pregnant women［J］. Matern Child Nutr，2014，10（1）：61-71.
［18］	Han C，Li C，Mao J，et al.High body mass index is an indicator of maternal hypothyroidism，hypothyroxinemia，and thyroid-peroxidase antibody positivity during early pregnancy［J］.Biomed Res Int，2015，2015：351831.
［19］	Völzke H，Lüdemann J，Robinson DM，et al.The prevalence of undiagnosed thyroid disorders in a previously iodinedeficient area［J］.Thyroid，2003，13（8）：803-810.
［20］	Brabant G，Beck-Peccoz P，Jarzab B，et al.Is there need to redefine the upper normal limit of TSH？［J］.Eur J Endocrinol，2006，154（5）：633-637.
［21］	Aksoy N，Yeler MT，Ayan NN，et al.Association between thyroid hormone levels and insulin resistance and body mass index［J］.Pak JMed Sci，2015，31（6）：1417-1420.
［22］	de Moura Souza A，Sichieri R.Association between serum TSH concentrationwithin the normal range and Adiposity［J］. Eur JEndocrinol，2011，165（1）：11-15.
［24］	Bétry C，Challan-Belval MA，Bernard A，et al.Increased TSH in obesity：evidence for a BMI-independent association with leptin［J］.Diabetes Metab，2015，41（3）：248-251.
［25］	Haddow JE，Craig WY，Palomaki GE，et al.Impact of adjusting for the reciprocal relationship between maternal weight and free thyroxine during early pregnancy［J］. Thyroid，2013，23（2）：225-230.