血管内皮细胞标志物在冠状动脉粥样硬化患者外周血中的表达及意义

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Abstract Objective To observe the level of blood vessel endothelial cell marker expression in peripheral blood of coronary arteriosclerosis patients and to discuss the significant.M ethods 127 patients diagnosed as coronary heart disease（CAD）from February 2014 to February 2015 in our hospital was randomly selected as the CAD group and 32 healthy person with physical examination was selected as the normal control group（NC group）.The CAD group was divided into acute coronary syndrome group（ACS group，n=56）and the stable coronary angina pectoris group（SAP group，n=17）.Enzyme link immune assay method and radio immune method were used to detect the expression of ET-1，NO，CD105，CD34，6-keto-PGF1αand TXB2.Correlation with CT coronary angiography was analyzed.Results ET-1，CD105 and TXB2expression was higher in ACS and SAP group than in NC group（P＜0.05），which was higher in ACS group than in SAP group（P＜0.05）.ET-1，CD105 and TXB2expression in calcium type，fiber type and soft type were different（P＜0.05），ET-1 and TXB2in calcium type was higher than in fiber and soft type（P＜0.05），CD105 in calcium type and fiber typewas higher than in soft type（P＜0.01）.Conclusion ET-1，CD105 and TXB2are correlated with CAD and may be helpful for diagnosis and predict the prognosis.

Key words： Blood vessel endothelialmarker Coronary arteriosclerosis disease Acute coronary syndrome

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	CHEN Jing
	ZHANG Lue

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CHEN Jing,ZHANG Lue. Expression and significant of blood vessel endothelial cellmarkers in peripheral blood of coronary arteriosclerosis patients[J]. 中国当代医药, 2016, 23(21): 137-139.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2016/V23/I21/137

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