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2017 Vol. 24, No. 2 Published: 2017-01-18

	4	Clinical efficacy and safety evaluation of Danxiong Jiuxin Qiwuji for chestblood stasis
		LIU Mei-song;WEN Fu-chun;JI Feng-lan;XU Hui-bo
		ObjectiveTo evaluate clinical efficacy and safety Danxiong Jiuxin Qiwuji in the treatment of chest-blood stasis.Methods420 patients with chest-blood stasis(initial onset angina pectoris of coronary heart disease)diagnosed and treated in inpatient and outpatient of Affiliated Hospital of Henan University of Traditional Chinese Medicine,Affiliated Hospital of Changchun College of TCM,Jilin Provincial People′s Hospital,Central Hospital of Changchun City, Changchun TCM Hospital,from February 2000 to November 2001,which were selected and divided into experimental group (n=316)and control group (n=104)according to different treatment methods,patients in the experimental group were given Danxiong Jiuxin Qiwuji,while patients in the control group were treated by Fufang Danshen Qiwuji,the course of treatment was 7 d.Curative effect of TCM syndrome,chest symptom severity rating points,chest pain score,clinical symptom score,clinical symptoms classification,tongue and pulse changes and scoring,changes of signs,dosage changes of nitroglycerin,effect of rapid analgesic,onset time and frequency of spraying,10 min ECG improvement,7 d ECG improvement,score of ECG before and after treatment,laboratory testing and adverse reactions were observed and compared.ResultsComparison of the two groups was statistically significant(P＜0.05)in curative effect of TCM syndrome,dosage changes of nitroglycerin,effect of rapid analgesic and onset time,especially for pain,night worse had significant effect.ECG quick action and short-term effects were significantly improved within group comparison.ConclusionDanxiong Jiuxin Qiwuji can significantly reduce symptoms in chest-blood stasis.It is fast analgesic,shorter medicine onset time,and reduce dose of nitroglycerin,experimental group is significantly better than control group.The clinical trials are safe,reliable,with no adverse reactions.
		2017 Vol. 24 (2): 4-9 [Abstract] ( 138 ) HTML (72 KB) PDF (0 KB) ( 36 )

	10	Inhibitory effect study of Resveratrol on proliferation of smooth muscle cell induced by angiotensinⅡ
		LI Zi-li;ZHANG Ruo-han
		ObjectiveTo explore inhibitory effect of Resveratrol on proliferation of smooth muscle cells induced by angiotensinⅡ.MethodsVascular smooth muscle cells(VSMCs)from rats were cultured in vitro.The cells were divided into angiotensin group,resveratrol gradient group,combined group and control group.The influence of resveratrol and angiotensin on proliferation of VSMCs was evaluated.The reaction on each group was lasted for 0,6,12,24 h,and proliferation of VSMCs was assessed by cell counting.The vitality of VSMCs was tested by MTT colorimetry and the results were compared and analyzed.ResultsWith regard to the results of cell counting,the general outcomes were angiotensin group, combination group,resveratrol gradient group,and control group from more to less,in which the cell counting of VSMCs in the angiotensin group was significantly higher than that in the control group (P＜0.05).In the resveratrol gradient group,the cell counting was lowest at 30 μmol/L when cultured for 24 h(P＜0.05).In the combination group,cell counting at 30 μmol/L and 100 μmol/L were greatly lower than that at 10 μmol/L(P＜0.05).Talking about cell viability,the general outcomes were angiotensin group,combination group,resveratrol gradient group,and control group from stronger to weaker.In the resveratrol gradient group,the cell counting was the highest at 30 μmol/L when cultured for 24 h (P＜0.05).In the combination group,the cell counting at 30 μmol/L and 100 μmol/L was both less than that at 10 μmol/L (P＜0.05).ConclusionResveratrol has a certain effect on proliferation of VSMCs,and has a strong inhibitory effect on proliferation induced by angiotensinⅡ.The effect differs in varied concentrations.
		2017 Vol. 24 (2): 10-12 [Abstract] ( 140 ) HTML (38 KB) PDF (0 KB) ( 34 )

	13	Research progress on non-surgical treatment of femoral head necrosis
		MAN Da;ZHAO Jian-min;LIU Rui;LI Qiang;WANG Xue-mei
		Femoral head necrosis is a hot spot in the field of orthopedics,its exact pathogenesis,disease characteristics are still inconclusive,Once found that most of patients have entered the middle and late stage of femoral head necrosis, when femoral head often presents a bone collapse or degeneration and necrosis,the process is no longer reversible,then patients often need to bear trauma of surgery.And clinical methods for its early diagnosis are not the same,overall effect of the treatment is not very satisfactory,with the deepening of biological engineering research,non-surgical treatment is more and more attention for that clinical treatment of femoral head necrosis provides a new idea.Non-surgical treatment of femoral head necrosis were reviewed in this paper.
		2017 Vol. 24 (2): 13-15转19 [Abstract] ( 155 ) HTML (44 KB) PDF (0 KB) ( 38 )

	16	Treatment progress of chronic heart failure
		LI Li-hua
		Chronic heart failure (CHF)is the ultimate outcome of many cardiovascular diseases,the major cause of death in most patients with cardiovascular disease is heart failure.How to reduce recurrence rate and fatality rate of CHF is the key point of the current study.By retrospective review of recent-year of related clinical literatures,the paper clarified the progress of modern prevention and treatment of CHF.After comparing western medicine treatment and traditional Chinese medicine (TCM)therapy,it is found that individualized TCM constitution identification gradually reflects its unique advantages in improving quality of life and decreasing re-hospitalization rate of CHF.
		2017 Vol. 24 (2): 16-19 [Abstract] ( 156 ) HTML (43 KB) PDF (0 KB) ( 36 )

	20	Study on the protective effects of mild hypothermia hemofiltration on viscera in patients with severe craniocerebral injury
		GUO Yu-mei
		ObjectiveTo investigate the protective effects of mild hypothermia hemofiltration on viscera in patients with severe craniocerebral injury.Methods60 patients with severe traumatic brain injury were admitted in our hospital from February 2015 to July 2016 were selected as subjects.they were randomly divided into control group and observation group,30 cases in each group.The control group was treated with conventional therapy of severe craniocerebral injury, and the observation group was further given hypothermia hemofiltration therapy on the basis of the therapy in the control group.The renal function indicators,neurological function indicators and inflammatory indicators were compared before and after the treatment in the two groups.ResultsThere were no significant differences in renal function,neurological function and inflammatory indicators between the two groups before treatment(P＞0.05).The renal function,neurological function and inflammation indicators in the observation group were lower than those of control group at different time points after the treatment(P＜0.05).ConclusionMild hypothermia hemofiltration has a better protective effect on viscera of the patients with severe craniocerebral injury,and its application value is higher.
		2017 Vol. 24 (2): 20-22 [Abstract] ( 155 ) HTML (39 KB) PDF (0 KB) ( 30 )

	23	Analysis the effect of Alprostadil Injection adjuvant therapy myocardial injury in sepsis
		HUANG Jin;TU Xia;LIAO Wei;ZHENG Wei
		ObjectiveTo explore the clinical effect of Alprostadil Injection adjuvant therapy myocardial injury in sepsis.Methods32 sepsis combined with myocardial injury patients from June 2014 to June 2016 of ICU were randomly divided into control group and treatment group.16 cases in each group.Patients in control group were used general early goal-directed therapy(EGDT),the treatment group were used venous pump Alprostadil Injection 10 μg with 5%Glucose Injection 20 ml on the basis of EGDT.The level of NT-proBNP and cTnI were respectively compared before treatment and after treatment for 3 and 7 days.Left ventricular ejection fraction (LVEF)of two groups before treatment and after treatment for 7 days were compared.Acute disease physiology and long-term health evaluation (APACHE)Ⅱ score, SOFA score changes of two groups before treatment and after treatment for 7 days were recorded.28 d mortality rate of two groups were observed.ResultsAfter treatment for 7 days,the level of NT-proBNP and cTnI in treatment group were lower than those of control group (P＜0.05),APACHEⅡ score and SOFA score were lower than those of control group (P＜0.05);After treatment for 7 days,the LVEF in treatment group obvious was lower than that of control group(P＜0.05); there was no significant difference in 28 d mortality rate between two groups(P＞0.05).ConclusionAlprostadil Injection can improve myocardial injury that resulted from sepsis,enhance patients′heart function,and is worth to application in clinical.
		2017 Vol. 24 (2): 23-25转28 [Abstract] ( 135 ) HTML (41 KB) PDF (0 KB) ( 39 )

	26	Clinical effect of digestive endoscopy in the treatment of upper gastrointestinal bleeding
		ZHANG Cui-lu;ZHOU Guo-yong;CHEN Qiao-qing
		ObjectiveTo explore the clinical effects of digestive endoscopy in the treatment of upper gastrointestinal bleeding.Methods40 cases with upper gastrointestinal bleeding who accepted treatments in our hospital from July 2013 to April 2016 were divided into control group and observation group by the random draw method,20 cases in each group,The control group were treated with conventional drug therapy while the observation group were applied the digestive endoscopic treatment.Then,the clinical value of digestive endoscopy in upper gastrointestinal hemorrhage were discussed.ResultsThe total clinical effect in the observation group was 95.00%,significantly higher than that of control group of 80.00% (P＜0.01),the average hemostasis time in the observation group was (0.85±0.65)d,significantly lower than that of control group of(1.70±0.68)d(P＜0.05);there were no significant adverse reactions in the two groups during the treatment period.ConclusionClinical application of endoscopic treatment in patients with upper gastrointestinal bleeding,which the clinical effects are significant and safe reliable,with clinical value.
		2017 Vol. 24 (2): 26-28 [Abstract] ( 146 ) HTML (36 KB) PDF (0 KB) ( 45 )

	29	Effect on continuous blood filtration therapy in the treatment of acute heart failure with lactic acidosis
		WU Chao-yu;LIU Xin;HU Ying;OUYANG Song-mao;ZHU Hong-quan
		ObjectiveTo investigate the effect of continuous blood filtration in the treatment of acute heart failure with lactic acidosis.Methods40 cases of patients with acute heart failure with lactic acidosis in our hospital from May 2014 to May 2016 were selected,they were randomly divided into continuous hemofiltration treatment group(experimental group)and hemodialysis treatment group(control group),20 cases in each group.The SBP,HR,RR,LVEF 24 h,urine volumes,blood lactic acid,CO2CP,pH and heart failure remission time,lactic acidosis corrected time and hospitalization time of the two groups were compared.ResultsThe SBP,HR,RR of the experimental group were significantly lower than those control group(P＜0.05),the LVEF,24 h urine volume were significantly higher than those of control group(P＜0.05),the blood lactate was significantly lower than that of control group (P＜0.05),the CO2CP,pH were significantly higher than those of control group(P＜0.05),the heart failure remission time,lactic acidosis the correct time,hospitalization time were significantly shorter than those of control group(P＜0.05).ConclusionThe effect of continuous blood filtration in the tr eatment of acute heart failure with lactic acidosis is better than conventional hemodialysis treatment.
		2017 Vol. 24 (2): 29-31 [Abstract] ( 155 ) HTML (39 KB) PDF (0 KB) ( 35 )

	32	Feasibility and safety of CO2laser combined with ALA-PDT in treating urethral condyloma
		YAO Ming-zhu;ZENG Yuan-juan;LAI Hong-tao;ZHANG Dong-xing
		ObjectiveTo explore the feasibility and safety of CO2laser combined with ALA-PDT in treating urethral condyloma.Methods112 urethral condyloma patients from March 2015 to March 2016 in our hospital were randomly selected and were divided into control group and observation group,56 cases in each group.Patients in control group were used CO2laser,and patients in observation group were used ALA-PDT on the basis of control group.Followed up for 24 weeks after the end of treatment,recurrence of warts and patients satisfaction with treatment was observed.ResultsAfter treatment,disposable cure rate at one week and two weeks in observation group were compared,the difference had no significant(P＞0.05).The difference of disposable cure rate at 4,8,12 and 24 weeks between two groups had statistical significant(P＜0.05).The recurrence rate of the two groups increased gradually,and to reach steady state at eighth weeks. Compared between two groups,the recurrence rate of observation group was obvious lower than that of control group,the difference was significant(P＜0.05).The patients satisfaction in observation group was 96.43%,obvious higher than that was 83.93%in control group,the difference was significant(P＜0.05).ConclusionUsing CO2laser combined with ALAPDT in treating urethral condyloma can improve disposable cure rate,reduce recurrence rate effectively and improve patients satisfaction.
		2017 Vol. 24 (2): 32-34 [Abstract] ( 151 ) HTML (37 KB) PDF (0 KB) ( 36 )

	35	Application of clinical pathway on improved fast-track surgery in thyriod surgery
		WU Zhi-hui;YAN Wei-hua;HUANG Jin-lin
		ObjectiveTo implement a better mode of clinical pathway of thyriod surgery by investigating the feasibility of pathway on improved fast-track sugery used in thyroid operation.Methods150 cases of thyroid surgery were selected in our hospital from June 2015 to November 2016 and divided into modified fast-track surgery thyroid surgery group (treatment group)and traditional fast-track thyroid surgery group(control group)according to the order of admission,75 cases in each group.The differences including preoperative anxiety,preoperative thirst and hunger,onset time of anesthesia,frequency of viomitting and aspiration during operation,operation time,intraoperative blood loss,postoperative recovery time,the first exhaust time after operation,incision pain and angina,postoperative complications,postoperative daily drainage,length of hospital stay,cost and satisfaction degree of the patients between two groups were compared and analyzed comprehensively.Results Subjective feeling in the treatment group was better than that in the control group (P＜0.01).Onset time of anesthesia,operation time,postoperative recovery time and the first exhaust time after operation in the treatment group was better than that in the control group (P＜0.01).Cost and length of hospital stay in the treatment group was significantly less than that in the control group(P＜0.01).There was no difference in postoperative complication rate between two groups(P＞0.05).ConclusionThe application of improved fast-track surgery in the treatment of thyroid surgery can not only reduce the pain of patients,but also save cost.It is worth to be popularized.
		2017 Vol. 24 (2): 35-38 [Abstract] ( 146 ) HTML (50 KB) PDF (0 KB) ( 36 )

	39	Research on change of serum MCP-1 level in obese patients with type 2 diabetes and its relationship with AS
		WANG Hui-hui;YAN Xiao-guang;YU Xiu-nan;ZHANG Hai-jun;SUN Zhe
		ObjectiveTo explore change of serum monocyte chemoattractant protein-1 (MCP-1)level in obese patients with type 2 diabetes mellitus(T2DM)and its relationship with atherosclerosis(AS).MethodsFrom January 2015 to August 2016,30 patients newly diagnosed as T2DM in obesity(T2DM obesity group,BMI≥28.0 kg/m2),30 patients in moderate size(T2DM non-obesity group,18.5 kg/m2≤BMI＜24.0 kg/m2),and 30 healthy participants after physical examinations (NC group,18.5 kg/m2≤BMI＜24.0 kg/m2).The levels of serum MCP-1 and other experimental indexes in empty stomach in each group were tested.Homeostasis model assessment of insulin resistance(HOMA-IR),insulin sensitivity index(ISI), and atherogenic index of plasma(AIP)were calculated.ResultsThe①levels of serum MCP-1 in the T2DM obesity group and T2DM non-obesity group were both much higher than that in the NC group.Serum MCP-1 in the T2DM obesity group was high than that in the T2DM non-obesity group with a statistical difference(P＜0.05).②Correlation analysis indicated that serum MCP-1 had positive relationships with body mass index(BMI),triglyceride(TG),total cholesterol(TC), fasting plasma glucose(FPG),HOMA-IR and AIP(P＜0.05).Serum MCP-1 was in a negative relationship with high-density lipoprotein cholesterol(HDL-C)or ISI(P＜0.05).③With regard to multiple stepwise regression analysis,it was indicated BMI,TC,FPG,and AIP were all enrolled into the regression equation based on the dependent variable of MCP-1 (P＜0.05).ConclusionMCP-1 is one of the key factors to promote occurrence and development of AS and IR.By testing the level of MCP-1 and implementing the corresponding intervention,it can relieve the degree of IR and AS.It is expected that MCP-1 will become a new cutting target for the treatment of macrovascular and microvascular complications in T2DM.
		2017 Vol. 24 (2): 39-41 [Abstract] ( 140 ) HTML (36 KB) PDF (0 KB) ( 32 )

	42	Clinical effect and safety of endoscopic thymidectomy via areola approach in treating thyroid benign diseases
		ZHANG Xiao-bing;ZHANG Wan-yu;LU Qiang;TANG Shi-long;CHEN Zhan-hui
		ObjectiveTo observe the clinical effect and safety of endoscopic thymidectomy via areola approach in treating thyroid benign diseases.MethodsA total of 62 patients with thyroid benign diseases who were treated in our hospital from June 2014 to June 2016 were enrolled and divided into observation group and control group by random number table,with 31 patients in each group.Patients in the observation group were treated with endoscopic thymidectomy via areola approach,while patients in the control group were treated with open surgery.The clinical pathophysiological parameters,VAS pain score,NSS cosmetic satisfaction and complication rate of two groups were recorded and compared.ResultsOperation time[(70.5±11.8)min],intraoperative blood loss[(41.2±16.5)ml],postoperative drainage time[(1.5± 0.4)d],postoperative drainage[(71.8±10.9)ml]and hospital stay time[(5.1±0.6)d]in the observation group was significantly less than (94.9±10.3)min,(73.6±11.8)ml,(2.8±0.9)d,(103.9±11.5)ml and (8.3±1.7)d in the control group (t= 8.6735,8.8930,7.2699,11.2797,9.7506;P＜0.01).VAS score of 6,12,24 h after surgery in the observation group[(4.13± 0.95),(3.27±0.71),(5.29±0.88)scores]was significantly lower than(5.28±0.73),(4.61±0.85),(3.73±0.94)scores in the control group (t=5.3443,6.7365,4.9294;P＜0.01),while NSS score of 1,3 months after surgery in the observation group [(8.37±1.15),(7.21±1.39)scores]was significantly higher than (4.16±1.03),(3.85±1.70)scores in the control group (t= 15.1832,8.5193;P＜0.01).Postoperative complication rate of the observation group was 6.5%,which had no significant difference than 16.1%of the control group(χ2=0.5193,P＞0.05).ConclusionEndoscopic thymidectomy via areola approach has the advantages of less trauma,sooner recover,less pain and better beauty effect in surgical treatment of thyroid benign diseases.
		2017 Vol. 24 (2): 42-44转47 [Abstract] ( 131 ) HTML (42 KB) PDF (0 KB) ( 45 )

	45	Study on the application of Insulin Glargine combined with Repaglinide in patients with type 2 diabetes and its impact on quality of life
		ZHANG Xu-tian
		ObjectiveTo discuss the application value of Insulin Glargine combined with Repaglinide in patients with type 2 diabetes and its impact on quality of life to provide the scientific reference data for treating type 2 diabetes.Methods70 patients with type 2 diabetes treated by our hospital from July 2015 to July 2016 were selected as object and they were divided into the experimental group and the control group,and each group had 35 cases.The control group was treated by Insulin Glargine,while the experimental group was treated by Insulin Glargine combined with Repaglinide.Glycosylated hemoglobin,postprandial 2 h blood glucose,fasting blood glucose,weight and quality of life score in patients between two groups before and after treatment was compared respectively.ResultsThere was a statistical difference of the total effective rate of treatment between two groups (P＜0.05).There was no statistical difference of Glycosylated hemoglobin,postprandial 2 h blood glucose,fasting blood glucose,weight and quality of life score between two groups before treatment(P＞0.05),after treatment,Glycosylated hemoglobin,postprandial 2 h blood glucose,fasting blood glucose,weight and quality of life score in experimental group was obviously better than that of control group(P＜0.05).ConclusionInsulin Glargine combined with Repaglinide has a higher application value in patients with type 2 diabetes treated,can significantly improve the quality of life of the patients.
		2017 Vol. 24 (2): 45-47 [Abstract] ( 134 ) HTML (36 KB) PDF (0 KB) ( 30 )

	48	Relationship between plasma 25-hydroxy vitamin D level and type 2 diabetes mellitus complicated with cerebral infarction
		LIN Xi-bing;YE Jun;HU Wu;LIU Yu;LEI Hong-yao
		ObjectiveTo explore relationship between serum plasma 25 hydroxy vitamin D[25(OH)VitD]level and type 2 diabetes mellitus(T2DM)complicated with cerebral infarction.Methods120 patients with T2DM hospitalized in our hospital from January 2015 to June 2016 were selected.Serum lipids,glycated hemoglobin C (HbAlc)and other blood biochemical parameters were detected by automatic biochemical analyzer,plasma 25(OH)VitD level was measured by ELISA.According to brain CT or MRI results,patients with T2DM were divided into with cerebral infarction group(DCI group)or no cerebral infarction group(DNCI group),relationship between plasma 25(OH)VitD level and T2DM complicated with cerebral infarction was analyzed.ResultsThe difference between two groups of gender,body mass index (BMI),duration of diabetes mellitus,systolic blood pressure(SBP),diastolic blood pressure(DBP)and 2-hour postprandial blood glucose(2 h PG)was not statistically significant(P＞0.05).However,age,fasting plasma glucose(FPG),glycosylated hemoglobin (HbA1c),carotid artery plaque rate in DCI group was significantly higher than that in DNCI group,while plasma 25(OH)VitD level was significantly lower than that in DNCI group(P＜0.05).Logistic regression analysis showed that 25(OH)VitD was an independent protective factor for T2DM complicated with cerebral infarction patients(OR 0.84,95%CI 0.72-0.97,P＜0.05),and carotid plaque was an independent risk factor for T2DM complicated with cerebral infarction patients(OR 1.23,95%CI 1.11-1.36,P＜0.05).ConclusionPlasma 25(OH)VitD is an independent protective factor for T2DM complicated with cerebral infarction patients.
		2017 Vol. 24 (2): 48-50 [Abstract] ( 148 ) HTML (37 KB) PDF (0 KB) ( 29 )

	51	Application value of sentinel lymph node biopsy in axillary lymph node dissection of radical mastectomy
		QIU Yan-ping;LI Yi-peng;LIN Wen
		ObjectiveTo explore the application value of sentinel lymph node biopsy (SLNB)in axillary lymph node dissection (ALND)of radical mastectomy.Methods50 patients with breast cancer in our hospital from April 2012 to April 2016 were selected as the study subjects and were treated with selective radical mastectomy.The patients were divided into the observation group and the control group according to whether undergoing SLNB,25 cases in each group. The observation group was given SLNB,and the control group was treated with ALND.According to the clinical pathological results,the sensitivity,specificity,accuracy and false negative rate of SLNB in predicting axillary lymph node metastasis were evaluated.Six months after operation,the outer diameters of midpoint(MP)of upper arm at affected side and uninjured side,the change rate of perimeter at 15 cm above the olecranon (C-15)were compared between the two groups.The quality of life was evaluated by quality of life(QOL)scale,and the incidence rates of complications in 1 year after operation was recorded.ResultsThe sensitivity,specificity,accuracy and false negative rate of SLNB in predicting axillary lymph node metastasis were 93.18%,83.33%,92.00%and 6.82%respectively.Six months after operation,the reduction rates of MP,C-15 and QOL score in the observation group was higher than that in control group,with significant difference (P＜0.01).The incidence rate of complications in the observation group in 1 year after operation was 4.00%, which was lower than 24.00%in the control group,with significant difference(P＜0.05).ConclusionSLNB can accurately predict axillary lymph node metastasis of breast cancer,guide the process of radical mastectomy and reduce surgical trauma and complications,it is worthy of clinical promotion and application.
		2017 Vol. 24 (2): 51-53 [Abstract] ( 154 ) HTML (37 KB) PDF (0 KB) ( 39 )

	54	Analysis of changes of peripheral blood lymphocyte subsets in patients with esophageal cancer before and after treatment
		ZENG Shang-gan
		ObjectiveTo explore the changes of peripheral blood lymphocyte subsets in patients with esophageal cancer before and after treatment.MethodsThe clinical data of 47 patients with esophageal cancer who were treated in our hospital from January 2012 to December 2014 were retrospectively analyzed.Lymphocyte subsets in peripheral blood of patients before and after treatment were detected.The levels of peripheral blood lymphocyte subsets in patients with different stages,lymph node metastasis and follow-up whether recurrence or metastasis were analyzed.ResultsThe level of CD3+,CD4+after treatment was higher than that before treatment,the level of CD8+,CD56+after treatment was lower than that before treatment,with significant difference(P＜0.05).The levels of CD3+and CD4+of peripheral blood lymphocytes in stageⅠ andⅡ before treatment was higher than that in stageⅢ andⅣ,with significant difference (P＜0.01).The levels of CD3+and CD4+of peripheral blood lymphocytes in stageⅠ andⅡ after treatment was higher than that in stageⅢ andⅣ,with significant difference (P＜0.01).The level of CD56+of peripheral blood lymphocytes before treatment in the patients without lymph node metastasis was lower than that in the patients with lymph node metastasis,with significant difference (P＜0.01).There was no significant difference in the level of CD3+,CD4+,CD8+,CD56+,CD19+of peripheral blood lymphocytes after treatment between the patients without lymph node metastasis and lymph node metastasis(P＞0.05).The level of CD4+in patients of no recurrence or metastasis before and after treatment was higher than that in patients of recurrence or metastasis,the level of CD8+,CD56+,CD19+in patients of no recurrence or metastasis before and after treatment was lower than that in patients of recurrence or metastasis,with significant difference (P＜0.05).ConclusionPatients with esophageal cancer have obvious cellular immune suppression.Detection of lymphocyte subsets can be used to monitor the immune status of patients,and assess the patient′s condition and predict the recurrence and metastasis of esophageal cancer patients.
		2017 Vol. 24 (2): 54-56转60 [Abstract] ( 143 ) HTML (44 KB) PDF (0 KB) ( 40 )

	57	Application value of serum carbohydrate antigen-125 and human epididymis secretory protein 4 detection in endometrial carcinoma
		WEN Dong-yu;XIONG Xiao-qin;XIN Yu-hong
		ObjectiveTo explore the application value of serum carbohydrate antigen-125 (CA-125)and human epididymis secretory protein 4 (HE4)detection in endometrial carcinoma (EC).Methods52 cases of EC in our hospital from January 2015 to September 2016 were selected as groupⅠ,and 53 patients with endometrial polyps in the same period were selected as groupⅡ,and 54 healthy persons in the same period were selected as groupⅢ.The levels of serum CA125 and HE4 were detected in three groups respectively.The difference in the each group and the difference in the different stages of EC were compared.The value of EC in the diagnosis of the patients was analyzed.ResultsThe level of CA125 and HE4 in groupⅠ was higher than that in groupⅡ and groupⅢ,with significant difference (P＜0.05).The level of HE4 in groupⅡ was higher than that in groupⅢ,with significant difference (P＜0.05).There was no significant difference in the level of CA125 between groupⅡ and groupⅢ (P＞0.05).There was no significant difference in the level of CA125 between stageⅠof groupⅠand groupⅡ,groupⅢ(P＞0.05).The level of HE4 in stageⅠof groupⅠ was higher than that in groupⅡ and groupⅢ,with significant difference (P＜0.05).In the comparison of different pathological grading,FIGO staging and whether to transfer of lymph node metastasis in stageⅢ,with the increase of malignancy,CA125 and HE4 levels increased,the difference was statistically significant(P＜0.05).In the myometrial invasion in stageⅠ,only the level of HE4 was statistically significant(P＜0.05).CA125,HE4 and EC were positively correlated,the correlation coefficient was 0.44,0.69,HE4 was more closely.With CA125＞35 U/ml and HE4＞74 pmol/L as the diagnostic critical value,the sensitivity and specificity of CA125 were 59.6%,84.1%,46.2%for HE4,99.1%.Youden index were 0.44,0.45 respectively.The results using ROC curve analysis HE4 showed that the maximum area under the curve of HE4 was 74 pmol/L,the sensitivity and specificity was 78.8%,88.8%respectively,Youden index was 0.68.The combined detection of two indexes in the diagnosis of EC could not significantly improve the diagnostic accuracy.ConclusionCA125 and HE4 can be used as detection markers for EC,which have certainly significance in predicting the degree of malignancy,and HE4 is better in diagnostic accuracy and predictive value,especially in the early stage.
		2017 Vol. 24 (2): 57-60 [Abstract] ( 142 ) HTML (43 KB) PDF (0 KB) ( 35 )

	61	Efficacy of laparoscopic radical gastrectomy in advanced gastric cancer and its influence on cellular immune function
		PENG Chun-sheng;LI Ming-sheng;WU Xin-wen
		ObjectiveTo explore the clinical efficacy of laparoscopic radical gastrectomy in advanced gastric cancer and its influence on cellular immune function，and to evaluate its clinical value.Methods 180 patients with advanced gastric cancer in our hospital from January 2012 to October 2014 were selected and randomly divided into the observation group and the control group,90 cases in each group.The control group was treated with traditional open surgery,and the observation group was treated with laparoscopic radical operation.The efficacy and postoperative immune function index of the two groups were compared.ResultsThe operation time of the observation group was longer than that of the control group,the postoperative hospital stay,postoperative exhaust time,incision length of the observation group was shorter than that of the control group,and the amount of intraoperative bleeding of the observation group was less than that of the control group,with significant difference(P＜0.05).There was no significant difference between the two groups in the number of dissection lymph nodes (P＞0.05).The level of CD3+,CD4+,CD8+,CRP and IL-6 after operation in the two groups was better than that before operation,with significant difference (P＜0.05).The level of CD3+,CD4+,CD8+after operation at 3,7,12 days in the observation group was higher than that in the control group at the same time,the level of CRP and IL-6 after operation at 3,7,12 days in the observation group was lower than that in the control group at the same time,with significant difference (P＜0.05).ConclusionThe clinical effect of laparoscopic radical operation in advanced gastric cancer is more significant than that of traditional open surgery,can reduce the influence on the patients cellular immune function,and it is worth of clinical promotion and application.
		2017 Vol. 24 (2): 61-63 [Abstract] ( 151 ) HTML (38 KB) PDF (0 KB) ( 36 )

	64	Short term effect of concurrent chemoradiotherapy and radiotherapy alone for esophageal carcinoma and its effect on immune function
		ZHANG Xiao-xiao
		ObjectiveTo evaluate short-term effects of concurrent chemoradiotherapy and radiotherapy alone for esophageal cancer and its effect on immune function.MethodsEighty patients with esophageal cancer admitted in our hospital from April 2013 to March 2016 were randomly divided into control group and observation group,40 cases in each group.Patients in the control group received radiotherapy alone,while patients in the observation group were given concurrent chemoradiotherapy.Short-term efficacy,immune function index(NK,Ts,Th,Th/Ts and total T cells)before and after treatment in two groups were compared.ResultsEffective rate in the observation group was 90.0%,significantly higher than 65.0%in the control group,and the difference was statistically significant(P＜0.05).There was no significant difference in the immune function between two groups before treatment(P＞0.05).After treatment,Th,Th/Ts,and total T cells was significantly lower than that in the control group(P＜0.05),but there was no significant difference in NK and Ts between two groups(P＞0.05).ConclusionConcurrent chemoradiotherapy is an effective treatment for esophageal cancer,which can improve the immune function of patients,but also has significant results.
		2017 Vol. 24 (2): 64-66 [Abstract] ( 127 ) HTML (37 KB) PDF (0 KB) ( 32 )

	67	EEG tracking analysis of radiation brain injury after laryngeal carcinoma radiotherapy
		TAN Kai-ru;YI Lan
		ObjectiveTo explore the feasibility of electroencephalogram(EEG)detection as early detection of radiation brain injury radiotherapy after laryngeal carcinoma radiotherapy.MethodsEEG of 74 patients with laryngeal carcinoma treated with radiotherapy in Central Hospital of Jiangmen City from May 2007 to May 2011 were followed up to observe before and after radiotherapy for 3 months and 1 year.ResultsEEG of 44 cases was abnormality after radiotherapy for 3 months.Followed up to observe to end(5 years),radiotherapy dose was positive correlation with abnormal EEG and radiation brain injury(r=0.478,0.417,P＜0.05).ConclusionPersistent EEG abnormalities or progression in patients with laryngeal cancer after radiation therapy is associated with radiation-induced brain injury.Abnormal EEG is mainly in the increases of tempus θ activity,which shows that brain damage of laryngeal carcinoma patients is mainly in the temporal lobe and suggests that EEG dynamic assessment after radiotherapy can help to early detect radiation brain injury in patients with laryngeal carcinoma.
		2017 Vol. 24 (2): 67-69 [Abstract] ( 152 ) HTML (37 KB) PDF (0 KB) ( 38 )

	70	Study of the clinical effect and impact factors of high intensity focused ultrasound in uterine myoma ablation
		HU Bo
		ObjectiveTo analyze the clinical effect and impact factors of high intensity focused ultrasound in uterine myoma ablation,and to provide reference basis for improving clinical efficacy of uterine fibroids ablation.MethodsFifty patients with solitary uterine myoma from January to December 2014 were selected as observation objects.All patients were treated with HIFU.Clinical effect was evaluated according to postoperative contrast enhanced ultrasound,and the related factor that impact the application effect was evaluated.ResultsThe treatment was markedly effective in 28 cases (56.0%),effective in 20 cases(40.0%)and ineffective in 2 cases(4.0%).The age,target skin distance,the location of fibroids,fibroids type,fibroids volume of the patients with markedly effective treatment effect and had statistically significant differences compared with ineffective patients(P＜0.01).ConclusionHigh intensity focused ultrasound in uterine fibroids ablation treatment has good application effect,but the age,the target skin distance,the location of fibroids,the type of fibroids,the volume of fibroids has a certain impact on the application effect of HIFU.
		2017 Vol. 24 (2): 70-72 [Abstract] ( 154 ) HTML (39 KB) PDF (0 KB) ( 42 )

	73	Clinical effect of Xiaoyao Pills on the SOD,MDA and interleukin of patients with pelvic inflammatory disease
		LYU Yan;CHEN Wan-lu
		ObjectiveTo observe the clinical effect of Xiaoyao Pills on the interleukin,MDA and SOD of patients with pelvic inflammatory disease.Methods From March 2015 to June 2016,100 patients with pelvic inflammatory disease treated in our hospital were selected,and they were randomly divided into observation group and control group according to the random number table method,50 cases in each group.The observation group was given the treatment of Xiaoyao Pills and conventional anti-inflammation;the control group just was given the treatment of the anti-inflammation. The clinical effect and clinical index of MDA,SOD and IL-4,IL-8 of the two groups were compared.ResultsThe effective rate of the observation group(96.0%)was significantly higher than that of the control group(80.0%),the difference was statistically significant(P＜0.05);the clinical index of MDA,SOD and IL-4,IL-8 of the observation group was even better than that of the control group,the differences were statistically significant(P＜0.05).Conclusion For patients with pelvic inflammatory disease,Xiaoyao Pills can greatly improve the clinical index of IL-4 and SOD,reduce the index of IL-8 and MDA.It is worthy of clinical promotion.
		2017 Vol. 24 (2): 73-75 [Abstract] ( 145 ) HTML (35 KB) PDF (0 KB) ( 44 )

	76	Effect of the application of Manpen Enemas in patients with fallopian tubal infertility after tubal reversal
		WU Dan;CHEN Wei-zhi;GUO Li-yan;YE Cui-fen;LUO Jian
		ObjectiveTo observe the clinical effect of Manpen Enemas in the treatment of fallopian tubal infertility after tubal reversal,and to explore its mechanism.MethodsSeventy-three patients with fallopian tube obstruction infertility from January 2014 to November 2015 in Foshan Hospital of Traditional Chinese Medicine were selected and they were randomly divided into the control group(n=33)and the observation group(n=40)according to the random number table method.The control group wasn′t given any treatmen,the observation group was treated by Manpen Enemas,two months for a course of treatment.The levels of C-reactive protein(CRP)were measured in different time points,the total pregnancy rate and the incidence of ectopic pregnancy in 1 year were counted.ResultsThe levels of CRP in the first postoperative day were significantly higher than the preoperative in two groups(P＜0.05).In the first postoperative day, level of CRP of the observation group was significantly lower than that of the control group(P＜0.05).The total pregnancy rate in the observation group was significantly higher than that of the control group (57.50%vs.33.33%,P＜0.05).ConclusionThe retention enemas with Manpen Enemas can significantly decrease the levels of inflammation and increase the pregnancy rate in patients with fallopian tube obstruction infertility.
		2017 Vol. 24 (2): 76-78 [Abstract] ( 165 ) HTML (38 KB) PDF (0 KB) ( 46 )

	79	Effect of biofeedback electrical stimulation in promoting the recovery of postpartum pelvic floor function
		CHEN Xue-mei;MEN Yan-hua;LI Man-ling
		ObjectiveTo study and discuss the effect of biofeedback electrical stimulation therapy in promoting the recovery of postpartum pelvic floor function.MethodsOne hundred patients with postpartum pelvic floor dysfunction from January 2014 to July 2016 in the Department of Obstetrics and Gynecology of our hospital were selected as the research objects,patients were divided into control group and observation group by adopting computer random grouping method,50 cases in each group.Patients in the control group were given routine pelvic floor muscle function exercise, and the observation group was treated with biofeedback and electrical stimulation on the basis of pelvic floor muscle function exercise.The clinical total effective rate,pelvic floor muscle strength recovery,pelvic floor muscle strength score, urine pad test score,vaginal maximum systolic pressure of patients were compared between the two groups.ResultsThe total clinical effective rate of patients in the observation group was 94%,was significantly higher than that of the control group(74%)(P＜0.05);rate of the pelvic floor muscle strength recovery in the observation group was significantly higher than that of the control group,and the pelvic floor muscle strength recovery time was shorter than that of the control group,the differences were statistically significant(P＜0.05);after treatment,pelvic floor muscle strength score,urine pad test score,maximum systolic blood pressure of the two groups were significantly increased,and that of the observation group was significantly higher than that of control group,the differences were statistically significant(P＜0.05).ConclusionThe clinical curative effect of biofeedback electrical stimulation in treatment of female postpartum pelvic floor dysfunction is significant,it can effectively promote the recovery of patients with pelvic floor muscle strength,enhance the pelvic floor muscle strength and vaginal contraction ability,can also reduce urinary incontinence.
		2017 Vol. 24 (2): 79-81转94 [Abstract] ( 132 ) HTML (44 KB) PDF (0 KB) ( 33 )

	82	Effect of early minimal feeding combined with non nutritive sucking on feeding tolerance of low birth weight infants

		ObjectiveTo investigate the effect of early minimal feeding combined with non nutritive sucking on feeding tolerance of low birth weight infants.MethodsSixty cases of low birth weight infants in our hospital from January 2013 to June 2016 were randomly divided into observation group and control group according to birth order,30 cases in each group.The observation group was fed with early minimal feeding and combined with non nutritive sucking,and the control group was fed with routine feeding.Adequate enteral nutrition time,recovery of birth weight and length of hospital stay of children in the two groups were observed and compared.ResultsThe ratio of feeding intolerance the observation group was significantly lower than that of the control group(20.00%vs.46.67%,P＜0.05);the time of reaching full enteral nutrition[(14.98±2.19)d vs.(19.47±2.55)d],the recovery time of birth weight[(8.36±2.57)d vs.(10.49±2.64)d]and hospitalization time[(13.36±2.18)d vs.(15.32±2.46)d]in the observation group were significantly lower than those of the control group,the differences were statistically significant(P＜0.05).ConclusionEarly minimal feeding combined with non nutritive sucking can reduce the proportion of feeding intolerance,promote gastrointestinal function and shorten the length of hospital stay,which can be used in the treatment of low weight infants.
		2017 Vol. 24 (2): 82-84 [Abstract] ( 116 ) HTML (35 KB) PDF (0 KB) ( 37 )

	85	Analysis of characteristics of pregnancy and childbirth in elderly maternal
		WEI Yu-hua
		ObjectiveTo study the characteristic pregnancy and childbirth in elderly maternal.Methods From January 2011 to January 2015,4200 cases of maternal prenatal and hospital childbirth in our hospital were selected as the research objects，according to the maternal age they were divided,602 cases of elderly maternal were set as group A（age≥35 years），3598 cases of group B were set as group B （age＜35 years）.The pregnancy and birth outcomes of the two groups were analyzed.Results The rate of pregnancy induced hypertension,diabetes，placenta previa，miscarriage，premature labor and placental abruption in the group A was significantly higher than that of the group B，the difference was statistically significant （P＜0.01）；maternal total labor of vaginal delivery，incidence of vaginal perineum incision，incidence rate of the soft birth canal laceration in the two groups had no statistically significant difference （P＞0.05）；the body quality，fetal abnormalities in the two groups of maternal perinatals had statistically significant difference（P＜0.05）.Conclusion For advanced maternal age，the incidence of all sorts of complications is significantly higher than non-elder pregnant women,and with higher incidence of the perinatal adverse situation of low weight of perinatal infant, neonatal asphyxia，shows that clinically relevant preventive care and treatment measures should be strengthened，the maximum extent to reduce maternal and infant adverse situation，improve and outcomes.
		2017 Vol. 24 (2): 85-87 [Abstract] ( 135 ) HTML (40 KB) PDF (0 KB) ( 35 )

	88	Value of hysteroscopy and laparoscopy in the diagnosis and treatment of intrauterine device
		WU You-gao
		ObjectiveTo study the value of hysteroscopy and laparoscopy in the diagnosis and treatment of ectopic intrauterine device.MethodsCase data of 50 patients whose built-in synthetic were suspected to be ectopic,broken,retained or embedded in the gynecological examination and the conventional intrauterine contraceptive apparatus extraction was unsuccessful in our hospital from December 2014 to March 2016 was retrospectively analyzed.All patients were diagnosed and treated with hysteroscopy and (or)laparoscopy,and the improvement of symptoms and satisfaction with the medical staff after taking out the birth control device was observed.ResultsIntrauterine devices of the 50 cases were successfully removed,including 8 cases of pelvic abdominal cavity,16 cases of fracture and residual,and 26 cases of embedded meal.The total effective rate of improvement of irregular vaginal bleeding,lumbosacral pain,abdominal pain,menstrual disorder was 100%.Patients′satisfaction with medical staff was 94%.ConclusionHysteroscopy and laparoscopy in the diagnosis and treatment of ectopic intrauterine device,can clearly ectopic location and surgical trauma is small,the success rate is high.It is worth clinical promotion.
		2017 Vol. 24 (2): 88-90 [Abstract] ( 112 ) HTML (40 KB) PDF (0 KB) ( 35 )

	91	Relationship between constitution of the pregnant woman and better born and better upbringing
		TANG Kai-ping;ZHENG Yan-ling
		ObjectiveTo evaluate the relationship between the constitution of the pregnant woman and better born and better upbringing in Liwan District Hualin street of Guangzhou.MethodsFrom October 2010 to September 2015,the TCM Constitution Identification Scale was used to investigate the constitution of the pregnant woman when they first come to build up pregnant file and gave constitution identification of traditional Chinese medicine according to TCM constitution classification and decision standard in the Community Health Center of Liwang District Hualin Street,then the situation in prenatal,postnatal and the situation of newborn was followed up,the influence of the constitution of yinyang harmony and yin-yang unharmony in the pregnant woman to prenatal and postnatal was evaluated.ResultsIn total 1892 effective cases,573 cases(30.29%)were in the constitution of yin-yang harmony and 1319 cases(69.71%)were in the constitution of yin-yang unharmony.The top three of the constitution of yin-yan unharmony were constitution of yang asthenia,constitution of qi asthenia,constitution of damp-heat.In the constitution of yin-yang harmony pregnant woman there were 142 cases with high risk pregnant,80 cases occured coplication prenatal and postnatal,11 cases of adverse pregnant outcome,24 cases of premature birth,25 cases of low-birth-weight,8 cases of Apgar scores≤7 points. The corresponding incidence rate were 24.78%,13.96%,1.92%,4.19%,4.36%,1.40%.While in the constitution of yinyang unharmony pregnant woman there were 437 cases with high risk pregnant,the other corresponding figures were 249,57,94,91,61.The corresponding incidence rate were 33.13%,18.88%,4.32%,7.13%,6.90%,4.62%,there were significant differences between yin-yang harmony and yin-yang un-harmony (P＜0.05).ConclusionThe constitution of yinyang harmony is better for good birth and good care.
		2017 Vol. 24 (2): 91-94 [Abstract] ( 131 ) HTML (43 KB) PDF (0 KB) ( 32 )

	95	Life quality and effect evaluation of patients with benign paroxysmal positional vertigo
		WANG Zhen-ying;CHEN Guo-feng;LI Zao-rong;HU Yong-cheng
		ObjectiveTo explore the effect of canalith repositioning procedure(CRP)in treating benign paroxysmal positional vertigo(BPPV)and the improvement of life quality before and after CRP.Methods75 BPPV patients from July 2014 to June 2016 were selected and treated with CRP and the effect was evaluated after treatment for 1 month and 3 months.The score of dizziness handicap inventory(DHI)and University of California at Los Angeles dizziness questionnaire(UCLA-DQ)in Chinese version were filled out and analyzed before treatment and after treatment for 3 months.Results1 month after first CRP,the total effective rate was 90.67%,3 months after first CRP,the total effective rate was 89.33%,and there was no significant difference (P＞0.05).Before CRP and 3 months after first CRP,both of DHI score and UCLA-DQ score had statistical significance (P＜0.05).Among 52 patients who evaluated as cured,there were 13.46%patients who still had recurrent vertigo.ConclusionCRP in treating BPPV has obvious effect,with high cure rate and obvious improve life quality,but some patients still need further treatment to cure the vertigo.
		2017 Vol. 24 (2): 95-97 [Abstract] ( 150 ) HTML (41 KB) PDF (0 KB) ( 31 )

	98	The clinical features of oral and maxillofacial space infection in patients with primary and secondary diabetes mellitus
		WU Xian-yi
		ObjectiveTo analyze the clinical features of oral and maxillofacial space infection in patients with primary and secondary diabetes mellitus.MethodsThe clinical data of 138 patients diagnosed with oral and maxillofacial space infection treated in department of oral and maxillofacial surgery from April 2011 to April 2016was retrospectively analyzed.According to diabetes history and clinical examination,they were divided into secondary diabetes mellitus group (39 cases),primary diabetic group(53 cases)and control group[46 cases(non diabetes)].ResultsIn the primary diabetes mellitus group,secondary diabetes group and control group,the space infection rate of men (62.26%,64.10%,62.26%) was obviously higher than that of women respectively(37.74%,35.90%,37.74%)(P＜0.05).The incidence rate of odontogenic infection in primary diabetes mellitus group(86.79%)was significantly higher than that of the secondary diabetes group(66.67%)and control group(67.39%)(P＜0.05).The heating rate of secondary diabetes mellitus group(100.00%) and the rate of multiple clearance (100.00%)was significantly higher than that in the primary diabetes mellitus group (90.57%,41.51%)and the control group(58.70%,19.57%)(P＜0.05).Abscess drainage in patients with diabetes mellitus were mainly for bacterial strains of Klebsiella pneumoniae,and there was significant difference between two groups(P＜0.01).ConclusionDiabetes mellitus complicated with infection of oral and maxillofacial space infection is more serious, and secondary diabetes mellitus is more serious than that of primary diabetic patients.Patients with diabetes mellitus should be attached great importance,especially those with secondary diabetes.
		2017 Vol. 24 (2): 98-100转103 [Abstract] ( 136 ) HTML (47 KB) PDF (0 KB) ( 38 )

	101	Clinical effect observation of orthodontics combined with repair in the treatment of defect of dentition complicated with dentognathic deformity
		AN Ying-jie;ZHANG Hui;QI Xiao-yu
		ObjectiveTo study the effect of orthodontics combined with repair in the treatment of defect of dentition complicated with dentognathic deformity.Methods84 patients with defect of dentition complicated with dentognathic deformity treated in our hospital from August 2013 to August 2015 were selected and they were divided into research group(n=42)and control group(n=42)by dynamic randomization.In the control group,direct repair was applied,while in the research group,orthodontics combined with repair was provided.The clinical effect and tooth recovery between two groups were compared.ResultsThe total effective rate in the research group (92.86%)was higher than that in the control group(69.05%)(P＜0.05).The good rate of dental tidiness,jaw-biting of posterior teeth,and jaw-covering of anterior teeth in the research group (95.24%,100.00%,95.24%respectively)were higher than those in the control group (80.95%,76.19%,78.57%respectively)(P＜0.05).ConclusionOrthodontics combining with repair in the treatment of defect of dentition complicated with dentognathic deformity can obtain a better effect with satisfied tooth recovery,which can be extensively used in clinic.
		2017 Vol. 24 (2): 101-103 [Abstract] ( 124 ) HTML (37 KB) PDF (0 KB) ( 35 )

	104	Effect of Mecobalamin Tablets auxiliarily treating ischemic optic neuropathy
		XIN Na;CHENG Hong-bo;LIU Jun
		ObjectiveTo analyze the effect of Mecobalamin Tablets auxiliarily treating ischemic optic neuropathy.Methods98 patients with ischemic optic neuropathy treated by our hospital from August 2015 to August 2016 were selected and they were divided into observation group(n=49)and control group(n=49)according to the parity of ID number. The control group was treated with Troxerutin Brain Protein Hydrolysate Injection,the observation group was treated with Mecobalamin Tablets on the basis of the treatment of control group.The therapeutic effect of visual acuity,visual field between two groups were compared.ResultsThe therapeutic effect of visual acuity and of visual field observation group was obviously better than those of control group (Z=2.071,P=0.038;Z=2.171,P=0.030).ConclusionThe effect of Mecobalamin Tablets auxiliarily treating ischemic optic neuropathy is exact,and it is effective and feasible,and it is helpful to improve the therapeutic effect,improve the visual acuity and visual field damage.It has a higher clinical promotion value.
		2017 Vol. 24 (2): 104-106 [Abstract] ( 131 ) HTML (36 KB) PDF (0 KB) ( 32 )

	107	Comparison of bulb type nasolacrimal duct implantation and dacryocystorhinostomy in the treatment of nasolacrimal duct obstruction
		LIU Jia-yan;LU Ya-mei;ZHOU Zhi-yan;ZHOU Yuan-qing;ZHU Su-wen
		ObjectiveTo compare the clinical effect of bulb type nasolacrimal duct implantation and dacryocystorhinostomy (DCR)in the treatment of nasolacrimal duct obstruction (NDO).Methods167 patients with NDO in our hospital from July 2011 to June 2016 were selected and divided into the minimally invasive group (65 cases,92 eyes)and the routine group(102 cases,119 eyes)according to the different treatment method.The minimally invasive group was treated with bulb type nasolacrimal duct implantation,the routine group was treated with DCR.The clinical effect of the two groups was compared.ResultsThe operation time and length of hospital stay in the minimally invasive group was shorter than that in the routine group,with significant difference(P＜0.05).The incidence rate of complications in the minimally invasive group was 10.89%,which was lower than 26.05%in the routine group,with significant difference (P＜0.05). There was no significant difference in the total effective rate between the two groups (P＞0.05).ConclusionBulb type nasolacrimal duct implantation and DCR have a considerable effect on NDO,while the former has more advantages in reducing the operation time and reducing the postoperative complications.
		2017 Vol. 24 (2): 107-109 [Abstract] ( 110 ) HTML (37 KB) PDF (0 KB) ( 28 )

	110	Effect analysis of Collutorymaxillary and Jinzhi Jieyin Gargle in the treatment of Chronic Gingivitis
		WU Zhi-gang
		ObjectiveTo explore the effect of Collutorymaxillary combined with Jinzhi Jieyin Gargle in the treatment of chronic gingivitis.Methods120 cases of chronic gingivitis in our hospital from February 2014 to January 2015 were selected and divided into the observation group and the control group according to random number table method,60 cases in each group.All patients were treated with ultrasonic scaling,the control group was given saline gargle,the observation group was given Collutorymaxillary combined with Jinzhi Jieyin Gargle.The treatment effect,the time of pain and swelling disappeared,and the gingival index(GI),plaque index(PI),gingival sulcus bleeding index(SBI)and oral hygiene index (OHI-S)before and after treatment were compared between the two groups.ResultsThe total effective rate of the observation group was higher than that of the control group,with significant difference (P＜0.05).The time of pain and swelling disappeared in the observation group was shorter than that in the control group,with significant difference (P＜0.05).The scores of GI,PI,SBI and OHI-S after treatment in the observation group was lower than that in the control group,with significant difference (P＜0.05).ConclusionCollutorymaxillary combined with Jinzhi Jieyin Gargle can effectively improve the treatment of chronic gingivitis,and the clinical symptoms can disappear earlier.
		2017 Vol. 24 (2): 110-112 [Abstract] ( 115 ) HTML (39 KB) PDF (0 KB) ( 36 )

	113	Randomized,single-blinded controlled clinical study of Ozone intra-ocular injection at different time intervals in the treatment of knee osteoarthritis
		CHEN Lin;ZHUO Jin-zhao;YAO Dong-wen
		ObjectiveTo explore the clinical effect of Ozone intra-ocular injection at different time intervals in the treatment of knee osteoarthritis.Methods94 patients with unilateral knee osteoarthritis in our hospital from March 2015 to March 2016 were selected and divided into group A and group B according to the random number table method,47 patients in each group.All patients were given intra-articular injection of 30 μg/ml of Ozone,with 20 ml/times and a total of 4 times. The patients in group A were treated once every 3 days.The patients in group B were treated once every 7 days.The VAS score,WOMAC arthritis index score,the level of IL-1β and TNF-α in knee joint fluid before and after treatment for 1 week were compared between the two groups.ResultsThe WOMAC score and VAS score after treatment of the two groups was better than that before treatment,with significant difference(P＜0.01).The WOMAC score and VAS score after treatment in group A was better than that in group B,with significant difference (P＜0.01).The content of TNF-α and IL-1β in group A was lower than that in group B,with significant difference (P＜0.05).ConclusionMedical Ozone intra-ocular injection is able to effectively treat knee osteoarthritis,shortened time interval can improve its therapeutic effect and improve joint function.
		2017 Vol. 24 (2): 113-115转118 [Abstract] ( 120 ) HTML (39 KB) PDF (0 KB) ( 33 )

	116	Clinical application of Dexmedetomidine in patients with heart failure in ICU
		ZHU Yun-lin;ZHU Hua-yong;ZHANG Wei-wei
		ObjectiveTo explore the application effect of Dexmedetomidine in ICU patients with heart failure.Methods54 patients with heart failure who were admitted to our hospital from October 2015 to February 2016 were selected and divided into the observation group(n=28)and the control group(n=26)according to the different sedative and analgesic drugs.The observation group was given Dexmedetomidine,the control group was given Propofol.The condition of improvement and prognosis were compared between the two groups.ResultsThe level of CK-MB,MYO,PaCO2after 24 hours in the two groups was lower than that before entering ICU,with significant difference (P＜0.05).The level of CKMB,MYO,PaCO2after 24 hours in the observation group was lower than that in the control group,with significant difference(P＜0.05).The APACHEⅡscore of the observation group after treatment was higher than that of the control group, and the Ramsay score of the observation group after treatment was lower than that of the control group,with significant difference(P＜0.05).The mortality rate of the observation group in 3 days was 10.7%,which was lower than 19.2%of the control group,with significant difference(P＜0.05).ConclusionThe application of Dexmedetomidine in ICU patients with heart failure,can promote the recovery of myocardial function,effectively alleviate the symptoms of heart failure,improve the prognosis of patients.
		2017 Vol. 24 (2): 116-118 [Abstract] ( 111 ) HTML (38 KB) PDF (0 KB) ( 42 )

	119	Application effect observation of Sufentanil combined with Flurbiprofen Axetil in postoperative controlled intravenous analgesia in hypertensive patients
		ZHOU Ke-ting;GUO Neng-qi;ZHU Xiao-bing;LIU Jian;XIAO Zhi-heng
		ObjectiveTo explore the clinical effect of Sufentanil combined with Flurbiprofen Axetil in postoperative controlled intravenous analgesia in hypertensive patients.Methods60 patients with hypertension underwent abdominal surgery(ASAⅠ-Ⅱ)under general anesthesia from April 2013 to April 2016 in our hospital were selected and randomly divided into group A and group B,30 cases in each group.Group A was given Sufentanil+Tropisetron+Normal Saline, group B was given Sufentanil+Flurbiprofen+Tropisetron+Normal Saline.The VAS score,sedation rating and nausea and vomiting rating at different time of 4,8,24,48 hours after operation in the two groups were compared,and the ratio of PCA effective/actual compression times,the arterial systolic blood pressure,heart rate and consumption of analgesics were recorded at each time point.ResultsThe VAS score,the ratio of PCA effective/actual compression times and the arterial systolic blood pressure at different time of 8,24,48 hours after operation in group B was lower than that in group A,with significant difference(P＜0.05).The proportion of patients who reached 2 or above sedation level at different time of 4,8,24,48 hours after operation in group A was higher than that in group B,with significant difference(P＜0.05).ConclusionIn hypertensive patients,postoperative use of Sufentanil combined with Flurbiprofen Axetil to analgesia can significantly reduce the dose of Sufentanil and adverse reaction,reduce the incidence of hypertension in perioperative period.
		2017 Vol. 24 (2): 119-121转127 [Abstract] ( 129 ) HTML (39 KB) PDF (0 KB) ( 37 )

	122	Clinical effect of Ebastine in the treatment of allergic rhinitis
		HE Zhi-qiang;CHEN Juan
		ObjectiveTo explore the clinical effect of Ebastine in the treatment of allergic rhinitis (AR).Methods110 patients with AR from November 2013 to April 2015 in our hospital were selected and randomly divided into the control group and the study group,55 cases in each group.The study group was treated with orally Ebastine,the control group was treated with orally Loratadine.The total effective rate,the incidence rate of adverse reactions and the level of serum adhesion molecule-1(VCAM-1),interleukin-10(IL-10),interleukin-4(IL-4)in the two groups were compared.ResultsThe total effective rate of the study group was 94.55%,which was higher than 80.00%of the control group,with significant difference (P＜0.05).There was no significant difference in the incidence rate of adverse reactions between the two groups(P＞0.05).The level of serum VCAM-1,IL-10 and IL-4 after treatment in the study group was lower than that in the control group after treatment,with significant difference (P＜0.05).ConclusionThe effect of Ebastine in the treatment of AR is significant,which can significantly improve the inflammatory reaction and related symptoms in patients with AR,it is worthy of popularization and application.
		2017 Vol. 24 (2): 122-124 [Abstract] ( 137 ) HTML (37 KB) PDF (0 KB) ( 40 )

	125	Clinical efficacy and safety observation of Benzhexol Hydrochloride combining with Piribedil in the treatment of Parkinson disease
		CHEN Hui;ZENG Wei-fu
		ObjectiveTo explore the clinical efficacy and safety of Benzhexol Hydrochloride combining with Piribedil in the treatment of Parkinson disease.Methods92 patients with Parkinson disease in our hospital from September 2012 to March 2016 were selected and divided into the control group and the study group according to the admission sequence, 46 cases in each group.The control group was treated with Piribedil,the study group was treated with Benzhexol Hydrochloride on the basis of the control group.The unified Parkinson disease rating scale (UPDRS)score and Webster score before and after treatment in the two groups were compared,and the SCL-90 factor scores and the incidence rate of adverse reactions were compared between the two groups.ResultsThe UPDRS score and Webster score after treatment in the study group was lower than that in the control group after treatment,with significant difference(P＜0.05).The SCL-90 factor scores after treatment in the study group was lower than that in the control group,with significant difference(P＜0.05).There was no significant difference in the incidence rate of adverse reactions between the two groups(P＞0.05).ConclusionThe clinical effect of Benzhexol Hydrochloride combining with Piribedil in the treatment of Parkinson disease is significant,which can effectively improve the clinical symptoms of the patients,improve the quality of life of patients,with less adverse reaction and high safety,it is worthy of clinical promotion and application.
		2017 Vol. 24 (2): 125-127 [Abstract] ( 140 ) HTML (39 KB) PDF (0 KB) ( 34 )

	128	Efficacy and safety analysis of Azithromycin in the treatment of acute bacterial lower respiratory tract infection
		LIU Yi
		ObjectiveTo explore the efficacy and safety of Azithromycin in the treatment of acute bacterial lower respiratory tract infection.Methods42 cases of acute bacterial lower respiratory infection from January 2015 to February 2016 in our hospital for treatment were selected and randomly divided into the observation group and the control group, 21 cases in each group.The control group was treated with Ceftazidime,the observation group was given Azithromycin. The cured and markedly effective rate,bacterial clearance rate and the incidence rate of adverse reactions in the two groups were compared.ResultsThe cured and markedly effective rate of the observation group was 90.48%,which was higher than 61.90%of the control group,with significant difference(P＜0.05).There was no significant difference in the bacterial clearance rate between the two groups(P=0.264).The incidence rate of adverse reactions in the observation group was 14.3%,which was lower than 47.6%in the control group,with significant difference (P＜0.05).ConclusionAzithromycin in the treatment of acute bacterial lower respiratory infection is safe and effective,less adverse reactions,it is worthy of clinical promotion and application.
		2017 Vol. 24 (2): 128-130 [Abstract] ( 133 ) HTML (34 KB) PDF (0 KB) ( 30 )

	131	Clinical effect of Ipratropium Bromide combined with Budesonide Suspension Liquid aerosol inhalation in the treatment of chronic cough after upper respiratory tract infection
		CHEN Shao-jun
		ObjectiveTo explore clinical effect of Ipratropium Bromide combined with Budesonide Suspension Liquid aerosol inhalation in the treatment of chronic cough after upper respiratory tract infection.Methods106 patients with chronic cough after upper respiratory tract infection from February 2015 to February 2016 in our hospital were selected and divided into the control group and the combined treatment group according to different treatment methods,53 cases in each group.The control group was treated with Ambroxol Aerosol Inhalation,the combined treatment group was treated with Ipratropium Bromide combined with Budesonide Suspension Liquid aerosol inhalation.The peak expiratory flow rate (PEFR)and eosinophil count(EOS)before and after treatment,cough disappearance time,pulmonary rales disappeared time,hospitalization time,clinical efficacy in the two groups were compared.ResultsThe PEFR level of the two groups after treatment was higher than that before treatment,and the level of EOS of the two groups after treatment was lower than that before treatment,with significant difference(P＜0.05).The level of PEFR in the combined treatment group after treatment was higher than that in the control group after treatment,and the level of EOS in the combined treatment group after treatment was lower than that of the control group after treatment,with significant difference (P＜0.05).The cough disappearance time,pulmonary rales disappeared time,hospitalization time in the combined treatment group was shorter than that in the control group,with significant difference (P＜0.05).The total effective rate of the combined treatment group was higher than that of the control group,with significant difference(P＜0.05).ConclusionThe clinical symptoms improvement of Ipratropium Bromide combined with Budesonide Suspension Liquid aerosol inhalation in the treatment of chronic cough after upper respiratory tract infection is significant,the total efficiency is higher,it is worthy of clinical promotion and application.
		2017 Vol. 24 (2): 131-133 [Abstract] ( 153 ) HTML (38 KB) PDF (0 KB) ( 27 )

	134	Effect of Benefiting Vital Energy and Eliminating Phlegm Prescription on complete blood count of patients with lung cancer chemotherapy
		PAN Xu-feng;HUANG Xue-wu
		ObjectiveTo evaluate the effect of Benefiting Vital Energy and Eliminating Phlegm Prescription on complete blood count in patients with non small cell lung cancer(NSCLC)during DP chemotherapy and observe the clinical curative effect.Methods63 cases with NSCLC treated form March 2014 to March 2016 were selected and they were divided into simple Western medicine treatment group(Western medicine group,33 cases)and integrated traditional Chinese and Western medicine treatment matching with Benefiting Vital Energy and Eliminating Phlegm Prescription(integrated traditional Chinese and Western medicine group,30 cases).Complete blood count,KPS score,quality of life score and the body weight and integral calculus of adverse symptoms before and after chemotherapy between two groups were compared.ResultsThere was a significant difference of complete blood count,KPS score and quality of life score in the forty-second days with chemotherapy between two groups(P＜0.05).There was no significant difference of body weight in the twenty-first and forty-second days with chemotherapy(P＞0.05).Integral calculus of cough,expectoration,shortness of breath in the integrated traditional Chinese and Western medicine group were significantly lower than those of western medicine group(P＜0.05).ConclusionThe change of complete blood count is less and quality of life is higher for Benefiting Vital Energy and Eliminating Phlegm Prescription matching with chemotherapy compared with simple chemotherapy.Combination of traditional Chinese and western medicine treating lung cancer deserves further study.
		2017 Vol. 24 (2): 134-136转140 [Abstract] ( 116 ) HTML (46 KB) PDF (0 KB) ( 37 )

	137	Effect comparison of integrated traditional Chinese and western medicine and western medicine treating sexual precocity
		CHEN Jun-ru;CHEN Shu-fen;WANG Qiang;WEI Guo
		ObjectiveTo compare the effect of integrated traditional Chinese and western medicine and western medicine treating sexual precocity.Methods60 children with sexual precocity treated by our hospital from June 2015 to June 2016 were selected.Patients were divided into two groups,and each group was 30 cases.The control group was treated with Triptorelin,and the study group was treated with integrated traditional Chinese and western medicine.After treatment,the index of secondary sex characteristics and hormone level between two groups were compared.ResultsBreast size,ovarian volume and uterine volume in study group after treatment were obviously smaller than those before treatment and those in control group after treatment,and the difference was statistical significant(P＜0.05).The level of LH,FSH and E2in study group after treatment were obviously lower than those before treatment and those in control group after treatment,and the difference was statistical significant(P＜0.05).ConclusionThe effect of integrated traditional Chinese and western medicine treating sexual precocity is better than that of western medicine.
		2017 Vol. 24 (2): 137-140 [Abstract] ( 118 ) HTML (43 KB) PDF (0 KB) ( 45 )

	141	Clinical effect of LEEP combined with traditional Chinese medicine powder in the treatment of chronic cervicitis
		BAO Hai-yan;WANG Duo;CHEN Yu-ying
		ObjectiveTo investigate clinical efficacy of LEEP combined with traditional Chinese medicine powder in the treatment of chronic cervicitis.Methods84 cases with chronic cervicitis in our Department of Gynaeology from January 2013 to June 2015 were selected and divided into treatment group and control group according to different treatment methods,42 cases in each group.The treatment group were given LEEP combined with traditional Chinese medicine powder,while the control group were given LEEP alone.Curative effect of two groups were observed.ResultsTotal effective rate in the treatment group was 97.62%,with 95.24%in the control group,and the difference was not statistically significant(P＞0.05);Vagnal bleeding time,vagnal drainage time and cervical wound healing time in the treatment group was better than that in the control group,and the difference was statistically significant(P＜0.01).ConclusionThe clinical efficacy of LEEP combined with traditional Chinese medicine powder in the treatment of chronic cervicitis is remarkable.
		2017 Vol. 24 (2): 141-143 [Abstract] ( 134 ) HTML (35 KB) PDF (0 KB) ( 31 )

	144	Effect of Edaravone combined with Qufeng Huatan Tongluo Decoction on patients with wind phlegm type of acute cerebral infarction
		HU Shu-yun;CHEN Li;HUANG Jin-hua
		ObjectiveTo investigate effect of Edaravone combined with Qufeng Huatan Tongluo Decoction on patients with wind phlegm type of acute cerebral infarction.Methods89 patients with acute cerebral infarction admitted to Hospital of Traditional Chinese Medicine of Yichun City from January 2013 to December 2015 were divided into observation group(n=45)and control group(n=44)according to random number table method.Patients in the control group were treated with Edaravone on the basis of routine treatment,while patients in the observation group were treated with Qufeng Huatan Tongluo decoction combined with traditional Chinese medicine based on the treatment of the control group.Therapeutic effects of two groups were observed.ResultsThe difference of TCM syndrome scores before treatment between two groups were not statistically significant(P＞0.05);after treatment,TCM syndrome scores of two groups were decreased,but which in the observation group was significantly lower than that in the control group(P＜0.05).Among efficacy of Chinese medicine,total efficiency rate in the observation group was 95.6%,significantly better than 72.7%in the control group,and the difference was statistically significant(P＜0.05).Among effect of nerve function defect,total effective rate in the observation group was 88.9%,significantly better than 70.5%in the control group,and the difference was statistically significant(P＜0.05);Barthel scores of two groups before treatment,the difference was not statistically significant(P＞0.05);after treatment,scores of two groups were improved,but which in the observation group increased more significantly than that in the control group(P＜0.05).ConclusionEdaravone combined with Qufeng Huatan Tongluo Decoction in the treatment of wind phlegm type of acute cerebral infarction is helpful to improve therapeutic effect.
		2017 Vol. 24 (2): 144-146 [Abstract] ( 134 ) HTML (44 KB) PDF (0 KB) ( 35 )

	147	Feasibility analysis of Yiqi Yangyin Xiaozheng Tongluo in treating early diabetic nephropathy
		JIANG Guo
		ObjectiveTo explore effect of Yiqi Yangyin Xiaozheng Tongluo in treating early diabetic nephropathy. Methods 56 patients with diabetic nephropathy in our hospital from February 2013 to February 2016 were selected and divided into experimental group and control group according to admission order,and each group was 28 cases.On the basis of routine treatment of diabetic,patients in the control group were given Irbesartan Tablet and traditional Chinese medicine placebo,and patients in the experimental group were given Yiqi Yangyin Xiaozheng Tongluo Decoction.Blood glucose index,changes of renal function and effects difference between two groups were compared.Results Total effective rate in the experimental group was 92.86%,obvious better than 71.43%in the control group (P＜0.05).After treatment,all of FBS,2 h PBG,HbA1c and UAER in two groups decreased obviously compared with before treatment(P＜0.05),while the index between two groups had no obvious difference after treatment(P＞0.05).After treatment,level of BUN in two groups had no obvious difference compared with before treatment(P＞0.05);there was no significant difference in BUN level after treatment between two groups(P＞0.05).Level of SCr in the experimental group and the control group was respectively(69.33±10.13)μmol/L and(73.98±10.07)μmol/L,and the difference was obvious(P＜0.05);level of SCr in the experimental group was significantly improved after treatment than before treatment(P＜0.05).Conclusion In treating diabetic nephropathy,Yiqi Yangyin Xiaozheng Tongluo Decoction and Irbesartan have similar effect on patients′blood glucose and renal function,but curative effect is relatively obvious and suitable for clinical use.
		2017 Vol. 24 (2): 147-149 [Abstract] ( 113 ) HTML (39 KB) PDF (0 KB) ( 39 )

	150	Study on the influence of self-directed learning readiness for illness cognitive in the patients with chronic
		DU Juan
		ObjectiveTo explore influence of self-directed learning readiness for illness cognitive in the patients with chronic in order to afford measures for health management of chronic.Methods592 patients with chronic were selected and who saw a doctor in internal medicine department of our hospital from March to June 2016,The Mishel sense of uncertainty in illness scale(MUIS)and self-directed 1earning orientation scale(SDLRS)were used and carried on the questionnaire survey.ResultsThe total score of MUIS in the patients with chronic was(108.58±17.36)scores,the total score of SDLRS was(133.89±24.38)scores.Correlation analysis showed that there was negative correlation between disease uncertainty feeling and self-directed learning readiness(r=-0.231 to-0.529,P＜0.01).Multiple regression analysis showed self-directed learning readiness could explain was 21.9%amount of variation of disease uncertainty feeling(R2= 0.219).Conclusion Self-directed learning is a predictive factor of illness cognitive in the patients with chronic.
		2017 Vol. 24 (2): 150-152 [Abstract] ( 103 ) HTML (41 KB) PDF (0 KB) ( 34 )

	153	Analysis of 102 cases reported of adverse drug reactions in our hospital in 2015
		YANG Huan;WANG Yang
		ObjectiveTo analyze the incidence of adverse drug reactions reported in our hospital,in order to guide clinical rational use of drugs and prevent the occurrence of Adverse drug reactions.MethodsRetrospective research the 102 cases of Adverse drug reactions were reported in our hospital in 2015,the influencing factors and manifestations of Adverse drug reactions were analyzed.ResultsIn 102 cases of Adverse drug reactions,the age of 10 and 21 to 30 years old patients has the highesc incidence of patients.Most adverse drug reactions were caused by antibacterial drugs which mainly included damage of the skin and its accessories.Route of administration was mostly for injection.The mainly types of adverse drug reactions were general.ConclusionWe should fully understand the adverse drug reactions,and theroute of administration should beselected appropriately.Meanwhile,close attention shoud be paid to the patients to ensure the rational use of drugs.
		2017 Vol. 24 (2): 153-155转158 [Abstract] ( 125 ) HTML (42 KB) PDF (0 KB) ( 33 )

	156	Study on effect of nutrition intervention on mild iron-deficiency anemia of female students in higher vocational college
		WANG Shou-hua;ZHAO Xiao-tian;SONG Yang
		ObjectiveTo investigate the effect of nutrition intervention on mild iron-deficiency anemia in female students in higher vocational college.MethodsFrom September 2014 to September 2015,1103 female students in higher vocational college were examined and the results of blood routine examination were analyzed.Among these participants, 90 cases from in mild anemia with hemoglobin ranging from 90 to 110 g/L were selected as research objects.Eightmonth nutrition intervention was performed.The blood routine examination and questionnaire investigation before and after intervention were conducted in order to evaluate the effect of nutrition intervention.ResultsAfter nutrition intervention,the hemoglobin(Hb),mean corpuscular volume(MCV),mean corpuscular hemoglobin(MCH)and mean corpuscular hemoglobin concentration (MCHC)of all the subjects were significantly higher than those before intervention,which were displayed statistical difference (P＜0.05).After nutrition intervention,the dietary behavior and life style in all the subjects were significantly improved after with statistical significance (P＜0.05).ConclusionNutrition intervention can effectively correct the iron-deficiency anemia of female students.
		2017 Vol. 24 (2): 156-158 [Abstract] ( 137 ) HTML (38 KB) PDF (0 KB) ( 25 )

	159	Epidemiological distribution characteristics of distal radial fractures inpatients in Guangzhou local region
		HUO Li-wei;WANG Guang-wei;YE Yong-liang;YU Wei-zhong
		ObjectiveTo analyze of Guangzhou bonesetting hospital distal of the radius fractures during the period of 5 years epidemiological characteristics and trends,help to understand the onset of the disease characteristics in Guangzhou local region.MethodsThe medical imaging computer system (PACS)was used,11 628 cases of the distal radius fractures in patients with clinical data were collected from July 2010 to December 2015 in our hospital,the age,sex,cause of injury, fracture classification and treatment methods for statistical were analyzed.ResultsA total of 11 628 cases,5156 cases of male,female 6472 cases;in patients with distal radius fractures with 50-59 patients most,accounting for 20.72%;causes hurt themselves in the highest,accounting for 62.1%;there was no significant difference in the fracture classification distribution between different gender significance (P>0.05),but the women of the distal radius fracture distribution was higher(male to female ratio was 0.80∶1).ConclusionAnalysis shows that the distal radius fracture patients in such aspects as individual features,cause of trauma has a certain distribution.
		2017 Vol. 24 (2): 159-161转167 [Abstract] ( 148 ) HTML (45 KB) PDF (0 KB) ( 35 )

	162	Practice and effect analysis of application of comprehensive evaluation index in hospital scientific research projects
		CHEN Liang-hua;ZHANG Xin-feng;JIN Cong-kai;YANG Wei-hong;LIU Yu-ping
		ObjectiveTo explore the law and trend of the increased comprehensive level of hospital scientific research projects so as to provide important basis for the implementation of scientific research project management in the future.MethodsScientific research projects of the First Hospital Affiliated Hospital of Guangzhou Medical University(top three hospitals)were taken as the statistical object,and the evaluation index of the related data from January 2014 to December 2016 was collected.Then,the research environment index,the base level index,the talent team index and the project quality index score of different projects in different stages were statistically analyzed.ResultsThe most solid score of research base between the first year(at the beginning of the study)for project and current problems(at the end of the study)was close,and the score was the highest in the second year for project;the score of research to find a breakthrough point was higher than that of the most solid score of research base,and the difference was statistically significant(P＜0.05).ConclusionSupport and development of the project in the middle and late stage is very important; the score of research project finding the breakthrough point is higher than that of project with good research base,and it indicates that finding the breakthrough point and solving problems are the focus of scientific development.
		2017 Vol. 24 (2): 162-164 [Abstract] ( 136 ) HTML (38 KB) PDF (0 KB) ( 32 )

	165	Application of PDCA cycle management in PICC catheterization #br#
	Application of PDCA cycle management in PICC catheterization #br#[J]. 中国当代医药, 2017,24(2): 165-167')" href="#">	YE Jing;TU Jing;XU Yan
		ObjectiveTo investigate the application effect of PDCA cycle management protocol on nursing care management of patients receiving PICC catheterization.Methods180 patients with PICC catheterization admitted into our hospital from September 2014 to September 2016 were selected and they were randomly divided into the observation group and the control group according to a random number table method,and there were 90 patients in each group.The control group was given traditional nursing model and the observation group was given PDCA cycle management.A detailed PDCA management plan was developed and implemented from the time of hospitalization.The quality of nursing care,incidence rate of complication for catheterization and satisfaction degree of patients were compared between two groups.ResultsThe score of basic nursing,nursing communication,health education and catheterization nursing in the observation group were significantly higher than those in the control group,and there was a statistical difference(P＜0.05);the incidence rate of complications[13.3%(12/90)]in the observation group was significantly lower than that of 36.7%(33/90) in the control group,and the difference was statistically significant(P＜0.05);the satisfaction degree of nursing in the observation group was 98.9%,which was significantly higher than that of 84.4%in the control group (76/90),and the difference wasstatisticallysignificant(P＜0.05).ConclusionPDCAcyclemanagementmodelforthenursing management of patients with PICC catheterization can effectively improve the quality of care,reduce the incidence of complications of catheterization and improve patients′satisfaction towards nursing care,which is worthy of clinical application and promotion.
		2017 Vol. 24 (2): 165-167 [Abstract] ( 111 ) HTML (38 KB) PDF (0 KB) ( 33 )

	168	Establishing four mechanisms to strengthen the medical quality management of maternal and child health care institutions
		ZHU Ji-wen;WANG Rong-gui
		The medical quality and safety is the lifeline for medical work and the core content of hospital management. The medical quality management in maternal and child health care institutions is relatively weak.As a maternal and child health care institution,our hospital established the restraint mechanism,assessment mechanism,punishment and incentive mechanism and long-term mechanism of medical quality management,through a medical quality and safety system was constructed to effectively ensure the quality of medical service and patients′safety.
		2017 Vol. 24 (2): 168-170 [Abstract] ( 105 ) HTML (43 KB) PDF (0 KB) ( 36 )

	171	Application of integrated management of nursing and image technology in nursing management of radiology department
		FU Zhong-xia
		ObjectiveTo explore the application effect of integrated management of nursing and image technology in the nursing management of radiology department.MethodsFrom January 2012 to January 2015,the clinical imaging technicians and nurses working in our hospital were selected as the subjects.Among all these participants,the number of clinical imaging technicians and nursing staff was 49 and 16.During observation period,the number of medical cases in the observation group and control group was both 100.In the control group,regular management mode was implemented, while in the observation group,the integrated management of nursing and image technology was adopted.The overall nursing quality index,nursing satisfaction from patients and their families,and nursing satisfaction from radiologists were compared.The ratio of contrast agent leakage after intervention and repeated scanning ratio in the two groups were calculated.ResultsThe overall nursing quality score after intervention in the observation group was significantly better than that in the control group(P＜0.01).Besides,nursing satisfaction score from patients and their families was greatly superior to that in the control group(P＜0.01).The nursing satisfaction score from radiologists in the observation group was much better than that in the control group (P＜0.01).In the observation group,the rate of contrast agent leakage and repeated scanning were significantly lower than those in the control group (P＜0.05).ConclusionThe integrated management of nursing and image technology can effectively enhance the overall nursing quality,patients′satisfaction and physicians′recognition on nursing work,reduce the proportion of contrast agent leakage and repeated scanning,and improve the efficiency in radiology department.
		2017 Vol. 24 (2): 171-173 [Abstract] ( 124 ) HTML (41 KB) PDF (0 KB) ( 37 )

	174	Application effect of pharmaceutical care in patients with type 2 diabetes
		ZHANG Ting-ting;WU Jun-ping
		ObjectiveTo discuss the application effect of pharmaceutical care in patients with type 2 diabetes.Methods86 hospitalized patients with type 2 diabetes diagnosed by our hospital from August 2015 to August 2016 were selected for clinical research.They were divided into two groups according to the single and double number of order number.The control group(single number,43 cases)was given routine medication instruction,while the trial group(double number,43 cases)was given pharmaceutical care on basis of routine medication instruction.Blood sugar control,medication compliance and adverse reaction were compared between two groups.ResultsFBG[(6.23±1.62)mmol/L],2 h PBG[(8.34±2.43) mmol/L]and adverse reaction rate(6.98%)in the trial group were lower than those of the control group[(9.56±2.64) mmol/L,(14.65±3.70)mmol/L,(32.56%),and medication compliance (95.35%)in the trial group was higher than that of the control group(72.09%)(P＜0.05).ConclusionThe pharmaceutical care in patients with type 2 diabetes can help to improve the clinical effect and medication compliance,reduce adverse reaction,hence it is worthy of clinical recommendation.
		2017 Vol. 24 (2): 174-176 [Abstract] ( 152 ) HTML (37 KB) PDF (0 KB) ( 34 )

	177	Problems andcountermeasuresencountered inthe informatization construction ofhospital
		DAI Yi
		As the healthcare reform deepens,hospitals are now exposed to more challenges.Hospital management must be further refined,greater demand is raised on informatization and the coverage is also broadened.A new peak of informatization construction in hospitals is created.The thesis analyzes the problems encountered in the informatization constructionof hospitaland discusses solutions according to the author′s hands-on experience.Intensifying informatization management is of great importance to facilitating informatization construction in hospitals.
		2017 Vol. 24 (2): 177-179 [Abstract] ( 148 ) HTML (39 KB) PDF (0 KB) ( 33 )

	180	Analysis of the effect of continuity nursing intervention on patients with diabetes
		XIE Xiu-mei;JIN Xue-fang;DENG Li-shan
		ObjectiveTo analyze the effects of continuity nursing on patients with diabetes mellitus.Methods120 cases of diabetic patients in our hospital from November 2014 to November 2014 were selected and randomly divided into observation group and control group,60 cases in each group,two groups were all received conventional diabetes drug treatment,the control group was given routine nursing care,and the observation group were given continuous nursing mode,two groups of patients with compliance,blood glucose control level,quality of life,the incidence of satisfaction and hypoglycemia were compared.ResultsThe quality of life and satisfaction of the observation group were significantly higher than those of control group(P＜0.05),the improvement of blood glucose control level was significantly better than that of control group (P＜0.05),and the incidence of hypoglycemia was lower than that of control group (P＜0.05).ConclusionContinuity nursing intervention can help patients with diabetes to control blood glucose level better,improve patient quality,compliance and nursing satisfaction,and reduce the incidence of hypoglycemia.
		2017 Vol. 24 (2): 180-182 [Abstract] ( 130 ) HTML (40 KB) PDF (0 KB) ( 29 )

	183	Effect of health education on self-nursing behavior of leukemia patients
		YE Qiao-ru
		ObjectiveTo analyze the effect of health education on self-nursing behavior of leukemia patients.Methods50 cases of leukemia patients who were treated from January 2015 to June 2016 were involved as the objects of this study and randomly divided into observation group and control group,25 cases in each group.Conventional health education model was adopted in control group,while,targeted health education was used in observation group.The behavior of compliance with doctor′s advice,SAS(self-rating anxiety scale),SDS(self-rating depression scale)and self-care behavior of two groups were observed.ResultsThere was no statistically significant difference between pre-interventional behavior of compliance with doctor′s advice of two groups (P＞0.05);the post-interventional behavior of compliance with doctor′s advice of observation group was significantly higher than that of control group(P＜0.01).There was significant difference between pre-and post-interventional SAS and SDS score of observation group(P＜0.01);there was no significant difference between the pre-and post-interventional SAS score and SDS score of control group(P＞0.05);there was significant difference between the post-intervention SAS and SDS score of observation group and control group(P＜0.01).The postinterventional self-care behavior of observation group was significantly higher than that of control group (P＜0.01);there was statistically significant difference between the pre-and post-interventional self-care behavior of observation group and control group (P＜0.05).ConclusionTargeted health education can effectively enhance the behavior of compliance with doctor′s advice of leukemia patients and improve the anxiety and depression of the patients,which promotes patients′self-care and is worth popularizing in clinical use.
		2017 Vol. 24 (2): 183-185 [Abstract] ( 122 ) HTML (40 KB) PDF (0 KB) ( 32 )

	186	Observation the effect of health care integrated health education model in improving health education satisfaction effect of department of hematology
		DUAN Hong-yan;ZHAO Zhong-yue
		ObjectiveTo explore the application effect of health care integrated health education model in chemotherapy patients in department of Hematology.Methods230 patients with chemotheraoy were selected from May to June 2016 in our department as objects.116 patients were selected as control group in May,and 114 patients were selected as observation group in June.Patients in control group were used routine nursing model for health education,and patients in observation group were used health care integrated health education model.After a week in hospital,health education satisfaction and acquisition of health knowledge in two groups were compared.ResultsThe satisfaction and passing rate of health education knowledge in observation group were respectively 98.25%and 90.35%,which were respectively 94.82%and 75.86%in control group,and the differences between two groups were significant(P＜0.05).ConclusionThe factors that affected health education effect include nurses and patients,and the knowledge level of nurses has direct relationship with health education effect.Using health care integrated health education model,which makes nurse and doctor work together,can improve nursing knowledge level,communication skills and health education consciousness and has meaning in improving health education satisfaction effect.
		2017 Vol. 24 (2): 186-188转191 [Abstract] ( 108 ) HTML (38 KB) PDF (0 KB) ( 35 )

	189	Early nursing intervention for patients with laparoscopic cholecystectomy and its application effect
		ZHANG Ping-ying;XU Han-rong;YE Yu-tao
		ObjectiveTo investigate the effect of early nursing intervention on patients with laparoscopic cholecystectomy.Methods 88 patients from November 2014 to January 2016 in our hospital who were analyzed with laparoscopic cholecystectomy,and they were randomly divided into intervention group and control group,44 cases in each group,the control group was received routine nursing care,while the intervention group was received early nursing intervention, nursing effect was compared between two groups.Results The operation effect of the intervention group was significantly better than that of control group,postoperative anxiety scores of the intervention group and the control group were (45.67±3.28)scores and(77.01±4.25)scores,the time of hospital stay were(3.38±0.98)d and(5.52±1.05)d,the differences were significant(P＜0.05);the incidence rate of the intervention group of complication was 6.82%,significantly lower than that of control group′s 22.73%,the difference was significant(P＜0.05);nursing satisfaction of intervention group was 90.91%,significantly higher than that of control group of 70.45%(P＜0.05).Conclusion For patients with laparoscopic cholecystectomy,early nursing intervention can significantly improve the effect of surgical treatment,postoperative recovery of patients with important significance,which is suitable for clinical use.
		2017 Vol. 24 (2): 189-191 [Abstract] ( 126 ) HTML (36 KB) PDF (0 KB) ( 35 )

	192	Application effect of early comprehensive rehabilitation training in postoperative fracture of knee joint
		FAN Xiao-hong;WANG Mei-lin
		ObjectiveTo explore the application effect of early comprehensive rehabilitation training in postoperative fracture of knee joint.Methods82 patients who conducted fracture of knee joint from May 2014 to May 2015 were studied and divided into study group and control group,according to random number table,41 cases in each group.The control group was used routine rehabilitation method,and the observation group was used early comprehensive rehabilitation training on the basis of control group.Exercise effect in observation group and control group was compared and analyzed.Evaluztion indexs liked treatment effective rate,range of knee joint motion and knee joint function were included.ResultsThe treatment effective rate in study group was 92.68%,higher than that of 75.61%in control group,the difference was significant(χ2=4.48,P＜0.05);the knee joint ROM and Lysholm score in study group were respectively (100.35±5.47)°and(84.29±4.42)scores,had large difference with those were respectively(76.38±6.11)°and(62.45±4.70) scores in control group,the differences were significant(P＜0.05).ConclusionUsing early comprehensive rehabilitation training for patients with knee joint fractures as soon as possible can promote the recovery of knee function.
		2017 Vol. 24 (2): 192-194 [Abstract] ( 105 ) HTML (36 KB) PDF (0 KB) ( 42 )

	195	Nursing experience of 41 cases of large-volume cerebral metastases Treated by SBRT
		DING Juan;ZHANG Yang-qiong
		ObjectiveTo explore the nursing experience of 41 cases of large-volume cerebral metastases who underwent SBRT.Methods41 cases of large-volume cerebral metastases who were treated with SBRT in our hospital from January to December 2015 were selected and randomly divided into control group(21 cases)and observation group(20 cases). The control group was treated with SBRT,while,the observation group was given comprehensive nursing care in the process of SBRT,the treatment results of two groups were compared.ResultsThe treatment efficiency rate of observation group was 100.0%,better than that of control group of 71.4%;the adverse effects rate of observation group was 10.0%, significantly lower than that of control group (42.9%);the nursing satisfaction of observation group was 95.0%,higher than that of control group (71.4%),with significant differences(P＜0.05).ConclusionAdministration of comprehensive nursing care to patients with large-volume cerebral metastases during SBRT improves the therapeutic effect and patients′nursing satisfaction,and reduces the risk of adverse reactions,which should be popularized in clinical practice.
		2017 Vol. 24 (2): 195-197 [Abstract] ( 126 ) HTML (39 KB) PDF (0 KB) ( 38 )

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