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Application effect observation of Sufentanil combined with Flurbiprofen Axetil in postoperative controlled intravenous analgesia in hypertensive patients |
ZHOU Ke-ting GUO Neng-qi ZHU Xiao-bing LIU Jian XIAO Zhi-heng |
Department of Anesthesiology,Hospital of Traditional Chinese Medicine of Zhongshan City in Guangdong Province, Zhongshan 528400,China |
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Abstract ObjectiveTo explore the clinical effect of Sufentanil combined with Flurbiprofen Axetil in postoperative controlled intravenous analgesia in hypertensive patients.Methods60 patients with hypertension underwent abdominal surgery(ASAⅠ-Ⅱ)under general anesthesia from April 2013 to April 2016 in our hospital were selected and randomly divided into group A and group B,30 cases in each group.Group A was given Sufentanil+Tropisetron+Normal Saline, group B was given Sufentanil+Flurbiprofen+Tropisetron+Normal Saline.The VAS score,sedation rating and nausea and vomiting rating at different time of 4,8,24,48 hours after operation in the two groups were compared,and the ratio of PCA effective/actual compression times,the arterial systolic blood pressure,heart rate and consumption of analgesics were recorded at each time point.ResultsThe VAS score,the ratio of PCA effective/actual compression times and the arterial systolic blood pressure at different time of 8,24,48 hours after operation in group B was lower than that in group A,with significant difference(P<0.05).The proportion of patients who reached 2 or above sedation level at different time of 4,8,24,48 hours after operation in group A was higher than that in group B,with significant difference(P<0.05).ConclusionIn hypertensive patients,postoperative use of Sufentanil combined with Flurbiprofen Axetil to analgesia can significantly reduce the dose of Sufentanil and adverse reaction,reduce the incidence of hypertension in perioperative period.
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