中药新药“丹芎救心气雾剂”对胸痹-心血瘀阻证的临床疗效及安全性评价

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Abstract ObjectiveTo evaluate clinical efficacy and safety Danxiong Jiuxin Qiwuji in the treatment of chest-blood stasis.Methods420 patients with chest-blood stasis(initial onset angina pectoris of coronary heart disease)diagnosed and treated in inpatient and outpatient of Affiliated Hospital of Henan University of Traditional Chinese Medicine,Affiliated Hospital of Changchun College of TCM,Jilin Provincial People′s Hospital,Central Hospital of Changchun City, Changchun TCM Hospital,from February 2000 to November 2001,which were selected and divided into experimental group (n=316)and control group (n=104)according to different treatment methods,patients in the experimental group were given Danxiong Jiuxin Qiwuji,while patients in the control group were treated by Fufang Danshen Qiwuji,the course of treatment was 7 d.Curative effect of TCM syndrome,chest symptom severity rating points,chest pain score,clinical symptom score,clinical symptoms classification,tongue and pulse changes and scoring,changes of signs,dosage changes of nitroglycerin,effect of rapid analgesic,onset time and frequency of spraying,10 min ECG improvement,7 d ECG improvement,score of ECG before and after treatment,laboratory testing and adverse reactions were observed and compared.ResultsComparison of the two groups was statistically significant(P＜0.05)in curative effect of TCM syndrome,dosage changes of nitroglycerin,effect of rapid analgesic and onset time,especially for pain,night worse had significant effect.ECG quick action and short-term effects were significantly improved within group comparison.ConclusionDanxiong Jiuxin Qiwuji can significantly reduce symptoms in chest-blood stasis.It is fast analgesic,shorter medicine onset time,and reduce dose of nitroglycerin,experimental group is significantly better than control group.The clinical trials are safe,reliable,with no adverse reactions.

Key words： Danxiong Jiuxin Qiwuji Chest-blood stasis Angina pectoris

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	LIU Mei-song
	WEN Fu-chun
	JI Feng-lan
	XU Hui-bo

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LIU Mei-song,WEN Fu-chun,JI Feng-lan, et al. Clinical efficacy and safety evaluation of Danxiong Jiuxin Qiwuji for chestblood stasis[J]. 中国当代医药, 2017, 24(2): 4-9.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2017/V24/I2/4

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