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| Efficacy of laparoscopic radical gastrectomy in advanced gastric cancer and its influence on cellular immune function |
| PENG Chun-sheng LI Ming-sheng WU Xin-wen |
| Department of the First Surgery,Hospital of Traditional Chinese Medicine of Yongfeng County in Jiangxi Province, Yongfeng 331500,China |
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Abstract ObjectiveTo explore the clinical efficacy of laparoscopic radical gastrectomy in advanced gastric cancer and its influence on cellular immune function，and to evaluate its clinical value.Methods 180 patients with advanced gastric cancer in our hospital from January 2012 to October 2014 were selected and randomly divided into the observation group and the control group,90 cases in each group.The control group was treated with traditional open surgery,and the observation group was treated with laparoscopic radical operation.The efficacy and postoperative immune function index of the two groups were compared.ResultsThe operation time of the observation group was longer than that of the control group,the postoperative hospital stay,postoperative exhaust time,incision length of the observation group was shorter than that of the control group,and the amount of intraoperative bleeding of the observation group was less than that of the control group,with significant difference(P＜0.05).There was no significant difference between the two groups in the number of dissection lymph nodes (P＞0.05).The level of CD3+,CD4+,CD8+,CRP and IL-6 after operation in the two groups was better than that before operation,with significant difference (P＜0.05).The level of CD3+,CD4+,CD8+after operation at 3,7,12 days in the observation group was higher than that in the control group at the same time,the level of CRP and IL-6 after operation at 3,7,12 days in the observation group was lower than that in the control group at the same time,with significant difference (P＜0.05).ConclusionThe clinical effect of laparoscopic radical operation in advanced gastric cancer is more significant than that of traditional open surgery,can reduce the influence on the patients cellular immune function,and it is worth of clinical promotion and application.
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