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2022 Vol. 29, No. 27
Published: 2022-09-27
 
 
5 Influencing factors of the severity of obstructive sleep apnea hypopnea syndrome
ZHENG Aifang ；WANG Liang ；LI Li
Objective To investigate the sleep apnea hypopnea index (AHI) grade in patients with obstructive sleep apnea hypopnea syndrome (OSASH) and its independent risk factors. Methods A total of 300 patients with sleep-disordered breathing admitted to the First People′s Hospital of Kashgar from July 2019 to July 2021 were selected as the research objects. According to AHI, AHI<5 times/h and polysomnography (PSG) indicated snoring were divided into simple snoring group. 5-14 times/h was considered as mild, 15-30 times/h was considered as moderate, and >30 times/h was considered as severe. All patients were divided into OSASH group. Univariate analysis was used to screen the related factors of OSASH patients, and multivariate logistic regression was used to analyze the independent risk factors of AHI classification. The factor analysis method was used to reduce the dimension of all factors, and the factors were rotated to extract the common factors. Results Among the 300 OSAHS patients, 168 were simple snoring (56.00%) and 132 were in the OSASH group (44.00%), of which 74 were mild (56.06%), 23 were moderate (17.42%), and 35 were severe (26.52%). There were significant differences in body mass index (BMI), history of hypertension, history of diabetes,neck circumference, abdominal circumference, systolic blood pressure, diastolic blood pressure, Epworth sleeping scale(ESS), AHI, frequency of apnea or hypopnea, and cumulative time of apnea or hypopnea between simple snoring group and OSASH group (P<0.05). There were statistically significant differences in BMI, ESS, AHI, times of apnea or hypopnea, cumulative time of apnea or hypopnea, and blood oxygen saturation in patients with different degrees of OSAHS (P<0.05). A total of 4 independent factors with common factor variance eigenvalue ≥1 were extracted,namely PSG monitoring related indicators, cardiovascular related indicators, age and medical history, and ethnic body mass indicators. Multivariate logistic analysis showed that BMI, ESS, AHI, times of apnea or hypopnea, and cumulative time of apnea or hypopnea were risk factors for the severity of OSAHS (OR＞1, P<0.05). Conclusion BMI, ESS, AHI,the number of apnea or hypopnea, and the cumulative time of apnea or hypopnea are independent influencing factors of the severity of OSASH patients. Clinical interventions should be targeted at these factors.
2022 Vol. 29 (27): 5-9 [Abstract] ( 43 ) HTML (1 KB)  PDF (738 KB)  ( 164 )
10 A meta-analysis of antibody positive rate after nine-valent HPV vaccination
ZHANG Chengfeng；DONG Yonghai； LIU Yun； YANG Cheng
Objective To investigate the rate of antibody positive conversion after 9-valent human papillomavirus(HPV) vaccination by meta-analysis. Methods Randomized controlled trials (RCT) were searched in PubMed, Embase,CNKI, Wanfang and VIP databases for the positive rate of antibody after vaccination with 9-valent HPV vaccine and with quadrivalent HPV vaccine until November 2021. Meta-analysis was performed using Stata 12.0 software. Results A total of 6 RCTs were included. The results showed that there was no statistically significant difference in anti-HPV-6/11/16/18 positive rate between 9-valent HPV vaccine and quadrivalent HPV vaccine after inoculation (P>0.05). The positive rates of anti-HPV-31/33/45/52/58 with nine-valent HPV vaccine were higher than those of quadrivalent HPV vaccine, and the differences were statistically significant (anti-HPV-31: RR=2.10, 95%CI=1.86-2.36; anti-HPV-33:RR-7.99, 95%CI=7.01-9.11; anti-HPV-45: RR=11.03, 95%CI=9.21-13.20; anti-HPV-52: RR=32.17, 95%CI=26.51-39.05; anti-HPV-58: RR=4.96, 95%CI=3.91-6.28). Conclusion Compared with quadrivalent HPV vaccine, nine-valent HPV vaccine has good immunogenicity.
2022 Vol. 29 (27): 10-14 [Abstract] ( 49 ) HTML (1 KB)  PDF (1179 KB)  ( 47 )
15 Effect of total glycosides in Glaucescent Fissistigma root on glycolysis,apoptosis and autophagy of lung adenocarcinoma NCI-H1299 cells
WANG Chenliang ；ZHANG Jing ；LIU Haoru ；LI Guanhua
Objective To explore the effect of total glycosides in Glaucescent Fissistigma root on glycolysis, apoptosis and autophagy of lung adenocarcinoma cells through Kirsten rats arcoma viral oncogene homolog (KRAS). Methods The NCI-H1299 cells were cultured in vitro and divided into the control group, the low-dose group of total glycosides in Glaucescent Fissistigma root, the high-dose group of total glycosides in Glaucescent Fissistigma root, the group of total glycosides in Glaucescent Fissistigma root+Vector, and the group of total glycosides in Glaucescent Fissistigma root+KRAS. The control group was treated with normal cultue medium, while the low-dose group received final concentration of 5 mg/ml of total glycosides in Glaucescent Fissistigma root, the high-dose group received final concentration of 20 mg/ml of total glycosides in Glaucescent Fissistigma root. The cells in the total glycosides in Glaucescent Fissistigma root+Vector group were transfected with a negative control vector first, and then the cells were treated with 20 mg/ml of total glycosides in Glaucescent Fissistigma root. After the cells were transfected with a KRAS overexpression vector, the total glycosides in Glaucescent Fissistigma root+KRAS group were treated with 20 mg/ml of total glycosides in Glaucescent Fissistigma root. The expression of KRAS mRNA in cells of each group was detected by qRT-PCR, and the expression of KRAS protein in cells of each group was detected by Western blot. And the cell proliferation inhibition rate was detected by MTT method. The glucose consumption and lactic acid content of cells in each group were detected by kit. The apoptosis rate was detected by flow cytometry, and the expression levels of apoptotic and autophagy-related proteins in cells of each group were determined by Western blot. Results The expression levels of KRAS, glucose consumption, lactic acid content, and Bcl-2 protein in the low-dose group and the high-dose group were lower than those in the control group, the cell proliferation inhibition rate and apoptosis rate, LC3-Ⅱ/Ⅰ, beclin-1 protein and Bax protein levels were higher than those in the control group, and the differences were statistically significant (P<0.05). The levels of KRAS, glucose consumption, lactic acid content, and Bcl-2 protein expression in the cells of the total glycosides in Glaucescent Fissistigma root+KRAS group were higher than those of the total glycosides in Glaucescent Fissistigma root+Vector group, and the differences were statistically significant (P<0.05). The levels of cell proliferation inhibition, apoptosis rate, LC3-Ⅱ/Ⅰ, Bax protein and beclin-1 protein in the the total glycosides in Glaucescent Fissistigma root+KRAS group were lower than those in the the total glycosides in Glaucescent Fissistigma root+Vector group, and the differences were statistically significant (P<0.05). There were no significant differences in the various indexes between the the high-dose group of total glycosides in Glaucescent Fissistigma root and the total glycosides in Glaucescent Fissistigma root+Vector group (P>0.05). Conclusion The total glycosides in Glaucescent Fissistigma root can inhibit the expression of KRAS, inhibit the glycolysis process of lung adenocarcinoma cells, and promote the apoptosis and autophagy of lung adenocarcinoma cells, thereby inhibiting the lung adenocarcinoma cells.
2022 Vol. 29 (27): 15-19转24 [Abstract] ( 35 ) HTML (1 KB)  PDF (994 KB)  ( 245 )
20 Inhibitory effect of shikonin on SN -38 glucuronidation catalyzed by UGT1A1*1 and UGT1A1*6
CHEN Yinnan； LIU Yong；CHEN Yueyue； LI Wei
Objective To compare the inhibitory effects of shikonin on SN-38 glucuronidation catalyzed by wild-type UDP-glucuronosyltransferase 1A1 (UGT1A1*1) and its common single nucleotide variant UGT1A1*6 in Asian population. Methods The production rate of SN-38 glucuronides (SN-38G), the metabolite of SN-38, was detected by ultraperformance liquid chromatography tandem mass spectrometry (UPLC-MS/MS). The inhibitory effects of shikonin on the metabolism of SN-38 catalyzed by UGT1A1*1 and UGT1A1*6 were evaluated by the change of the residual activity of the enzymes. The half-maximal inhibitory concentration (IC50) of shikonin on SN-38G in UGT1A1*1 and UGT1A1*6 systems was calculated by nonlinear regression. Results The reaction rates of UGT1A1*1 and UGT1A1*6 catalyzed SN-38 glucuronidation by shikonin (1, 10, 100 μmol/L) were lower than those of the control group, with statistical significances (P<0.05). The IC50 of shikonin on UGT1A1*1 and UGT1A1*6 were 4.357 μmol/L and 7.353 μmol/L, respectively. Conclusion Shikonin may cause herbal drug interaction by inhibiting UGT1A1, and thereby reduce the metabolic clearance SN-38, which is the active form of the prodrug irinotecan. Thus, the combination of shikonin and irinotecan should be avoided in clinical practices to prevent the accumulation of SN-38 in the body and the consequent adverse reactions.
2022 Vol. 29 (27): 20-24 [Abstract] ( 37 ) HTML (1 KB)  PDF (792 KB)  ( 69 )
25 The expression and correlation of P300/CBP-related factor and P53 in cervical cancer
LI Lei；ZHANG Juntao；CAO Shuping
Objective To explore the expressions of P300/CBP-related factor (PCAF) and P53 in cervical carcinoma and the relationship between the two factors. Methods From June 2016 to June 2020, 79 cervical cancer tissue samples admitted to Dongying District People′s Hospital of Dongying City were selected as the experimental group, and 20 normal cervical tissue samples were selected as the control group. Immunohistochemical SP method was used to detect the expression of PCAF and P53 in cervical tissues. The expression characteristics and correlation of PCAF and P53 were compared between the two groups. Results The positive expression rate of PCAF in the experimental group was 41.8%,which was lower than 80.0% in the control group, and the difference was statistically significant (P<0.05). The positive expression rate of PCAF in the experimental group decreased with the increase of clinical stage and pathology classification of cervical cancer, and the difference was statistically significant (P<0.05). There was no significant difference in the positive expression rate of PCAF among patients in experimental group of different ages and histological types (P>0.05).The positive expression rate of P53 in the experimental group(78.5%)was higher than that in the control group(0%),and the difference was statistically significant (P<0.05). The positive expression rate of P53 in the experimental group increased with the increase of clinical stage and pathology classification of cervical cancer, and the difference was statistically significant (P<0.05). There was no significant difference in the positive expression rate of P53 among patients in experimental group of different ages and histological types(P>0.05).There was a moderate negative correlation between the expression of PCAF and P53 in the experimental group (r=-0.493,P<0.05).Conclusion The expression rate of PCAF in cervical cancer is low or even zero, which is negatively correlated with the active expression of P53. It is suggested that PCAF and P53 may play essential roles in the development of cervical cancer and may become important biological molecular markers for cervical cancer.
2022 Vol. 29 (27): 25-28 [Abstract] ( 44 ) HTML (1 KB)  PDF (643 KB)  ( 58 )
29 Application effect of blade needle therapy in patients with residual dizziness after repositioning maneuvers of benign paroxysmal positional vertigo
MAI Shuyan ；ZENG Wenbi ；PAN Qingdong； LI Wenchun
Objective To explore the application effect of blade needle therapy in patients with residual dizziness after successful repositioning maneuvers of benign paroxysmal positional vertigo. Methods A total of 60 patients with residual dizziness after successful repositioning maneuvers of benign paroxysmal positional vertigo admitted to Shunde Hospital of Guangzhou University of Chinese Medicine from January 2019 to July 2021 were selected as the research objects.They were divided into observation group (30 cases) and control group (30 cases) by simple random sampling method.The patients in the observation group were treated with blade acupuncture, and the control group were treated with vestibular rehabilitation training. The durations of residual dizziness after treatment, dizziness handicap inventory (DHI)and vestibular disorders activities of daily living (VADL) scores before and 1 month after treatment were compared between the two groups. Results The duration of residual dizziness after treatment in the observation group was shorter than that in the control group, and the difference was statistically significant (P＜0.05). There were no significant differences in DHI and VADL scores between the two groups before treatment (P＞0.05). After treatment, the DHI and VADL scores of two groups were lower than those before treatment, and the DHI and VADL scores of the observation group were lower than those of the control group, with statistically significant differences (P＜0.05). Conclusion For patients with residual dizziness after successful repositioning maneuvers, blade acupuncture treatment had significantly improvement on the symptoms of residual dizziness.
2022 Vol. 29 (27): 29-33 [Abstract] ( 35 ) HTML (1 KB)  PDF (703 KB)  ( 129 )
34 Research progress of vitamin D in prevention of gestational diabetes mellitus
ZHANG Ning；DING Xiaohua；HE Ruizhen；ZHOU Rui； ZHANG Xuefen
Gestational diabetes mellitus is a common complication of pregnancy, which can cause many adverse pregnancy outcomes, such as premature delivery, macrosomia, premature rupture of membranes, neonatal hypoglycemia,polyhydramnios and cesarean section. The incidence of gestational diabetes mellitus in China is increasing, which has seriously threatened maternal and infant health. Vitamin D has been found to maintain a normal range of glucose tolerance and improve insulin sensitivity. During pregnancy, pregnant women′s demand for vitamin D increases 4-5 times under the action of hormone levels and fetal bone growth and development, especially in the first trimester, the incidence of vitamin D deficiency is higher. Vitamin D supplementation during pregnancy can effectively reduce the risk of gestational diabetes, reduce the incidence of maternal and infant adverse outcomes, and provide a guarantee for the safety of pregnancy. This article reviews the recent studies on the relationship between vitamin D and pregnancy outcomes of gestational diabetes mellitus, included the effect of different doses of vitamin D deficiency, different ways of supplementation, different time of supplementation, and combined with different adjuvant therapy on the incidence of gestational diabetes mellitus and maternal and infant outcomes, to provide a scientific basis for the clinical application of vitamin D in improving adverse maternal and infant outcomes of gestational diabetes mellitus.
2022 Vol. 29 (27): 34-37 [Abstract] ( 41 ) HTML (1 KB)  PDF (496 KB)  ( 122 )
38 The research progress of pathogenesis and treatment in vulvar white lesion
CUI Danfeng；JIA Qinglan
White lesions of the vulva is a group of chronic lesions with hypopigmentation and degeneration of the skin and mucosal tissues of the vulva, including squamous hyperplasia of vulva, vulva lichen sclerosus and other skin diseases. Clinical manifestations of vulva pruritus and skin mucous membrane thickening or atrophy, repeated scratching thickening can be barklike change, or atrophy in ivory sheep-skinlike change, severe can lead to vulva shape change,vaginal contracture. The pruritus symptom and the destruction of vulva structure seriously affect the quality of life and physical and mental health of patients. And delay does not heal, need repeated treatment. The etiology of this disease is unknown, and the possible pathogenesis is mainly related to immune factors, genetic inheritance, inflammatory infection, cell proliferation and apoptosis. In recent years, glucocorticoid is the first choice to control pruritus and has good curative effect. Other drugs and physical therapy can be used when glucocorticoid therapy fails. Chinese and English literatures on white lesions of the vulva were searched, and the following review was summarized and formed, hoping to provide reference for clinicians in diagnosis and treatment.
2022 Vol. 29 (27): 38-41 [Abstract] ( 37 ) HTML (1 KB)  PDF (487 KB)  ( 102 )
42 Clinical status of follicular dendritic cell sarcoma
CHEN Dinglang；JING Renyi；CHEN Dingzhi；SU Zhixiong
Follicular dendritic cell sarcoma (FDCS), as a clinically visible malignant tumor, has not yet formed a unified description of its pathogenesis, clinical manifestations, diagnosis and treatment, which leads to its easy misdiagnosis and delayed diagnosis. Due to the different location of the disease, many patients often have different symptoms such as slow-growing painless mass, abdominal manifestations including abdominal pain, abdominal distension and abdominal mass, and constitutional symptoms. If not diagnosed as soon as possible and scientific treatment measures are taken,the physical and mental health of patients will be seriously affected.In the existing diagnosis and treatment records of FDCS, surgery is basically the main means to control the patients′ condition. Therefore, this paper analyzes the current clinical situation of FDCS from the perspective of review and tries to describe the related etiology and pathogenesis, clinical manifestations, imaging features, pathological features, differential diagnosis, treatment, and prognosis of FDCS, to deepen our understanding of FDCS and provide a new perspective for future research on its pathogenesis.
2022 Vol. 29 (27): 42-45 [Abstract] ( 40 ) HTML (1 KB)  PDF (486 KB)  ( 276 )
46 Effect of endoscopic ligation combined with Omeprazole in the treatment of liver cirrhosis with upper gastrointestinal bleeding
LI Fang
Objective To observe the efficacy of endoscopic ligation combined with Omeprazole in the treatment of liver cirrhosis with upper gastrointestinal bleeding. Methods A total of 82 patients with liver cirrhosis complicated with upper gastrointestinal bleeding who were treated in Pingxiang Ganxi Cancer Hospital were selected as research objects from May 2017 to May 2020, and they were divided into observation group (42 cases) and control group (40 cases) according to the coin tossing method. The control group was given endoscopic ligation, while the observation group was treated with endoscopic ligation combined with Omeprazole. The efficacy, clinical indicators and liver function before and after treatment were compared between the two groups. Results The total effective rate of treatment in the observation group was higher than that in the control group, with statistically significant difference (P＜0.05). The blood transfusion volume of the patients in the observation group was less than that in the control group, and the hemostasis time,symptom relief time and hospital stay were shorter than those in the control group, with statistically significant differences (P＜0.05). The levels of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) and total bilirubin (TBil) after treatment in the observation group were lower than those in the control group, with statistically significant differences (P＜0.05). Conclusion Endoscopic ligation combined with Omeprazole has a significant efficacy in the treatment of liver cirrhosis with upper gastrointestinal bleeding, and it can quickly stop bleeding, improve liver function, accelerate recovery of patients and reduce hospital stay.
2022 Vol. 29 (27): 46-48 [Abstract] ( 34 ) HTML (1 KB)  PDF (609 KB)  ( 59 )
49 The relationship between Helicobacter pylori infection and nonalcoholic fatty liver disease in Lianyungang
LIN Huanhuan； ZHANG Hui；SONG Chengwen ；ZHAO Changdong； LUO Hongbo； CHEN Xian
Objective To study the relationship between Helicobacter pylori (Hp) infection and nonalcoholic fatty liver disease (NAFLD) in Lianyungang. Methods Clinical data of 8 125 people who had outpatient physical examinations in Lianyungang from January to December 2019 were retrospectively analyzed, 3 238 people with nonalcoholic fatty liver disease were divided into the NAFLD group, and 4887 normal people who underwent physical examinations during the same period were divided into the control group. The Hp infection situation of two groups of people was recorded, the Hp infection rate of two groups was calculated, and the relationship between NAFLD severity and Hp infection was analyzed. Results The total prevalence of NAFLD was 39.9%. The infection rate of Hp in the NAFLD group was higher than that in the control group, and the difference was statistically significant (P＜0.05). There was no significant difference between the severity of NAFLD and Hp infection in the NAFLD group (P＞0.05). Conclusion Hp infection rate of people with NAFLD in Lianyungang is higher than that of normal people, but there is no significant relationship between the severity of NAFLD and Hp infection.
2022 Vol. 29 (27): 49-51转55 [Abstract] ( 38 ) HTML (1 KB)  PDF (647 KB)  ( 56 )
52 Application effect of dynamic ultrasound guided indwelling needle puncture on patients with difficult intravenous access in department of cardiovascular medicine
LI Yin； CAI Hong ；WU Xiaofeng
Objective To explore the application effect of dynamic ultrasound guided indwelling needle puncture on patients with difficult intravenous access in department of cardiovascular medicine. Methods A total of 60 patients admitted to department of cardiovascular medicine of General Hospital of Pingxiang Mining Group Co., Ltd. between January and December 2021 were selected as the research subjects, and were divided into the control group and the observation group according to the random number table method, with 30 cases in each group. The control group underwent traditional venous indwelling needle puncture while the observation group was given indwelling needle puncture under dynamic ultrasound guidance. The number of punctures, success rate of one-time puncture, puncture time of indwelling needle, indwelling time of indwelling needle and degree of pain at puncture site were observed in the two groups of patients, and the occurrence of adverse reactions after puncture in the two groups were recorded. Results The number of punctures in the observation group was less than that in the control group, the success rate of one-time puncture was higher while the score of visual analogue scale (VAS) was lower compared to the control group, and the puncture time of indwelling needle was shorter than that in the control group while the indwelling time of indwelling needle was longer than that in the control group, the differences were statistically significant (P<0.05). The incidence rate of adverse reactions in the observation group after surgery was lower than that in the control group, the difference was statistically significant (P<0.05). Conclusion Indwelling needle puncture under dynamic ultrasound guidance can effectively enhance the puncture quality and reduce the occurrence of adverse reactions after puncture.
2022 Vol. 29 (27): 52-55 [Abstract] ( 31 ) HTML (1 KB)  PDF (585 KB)  ( 87 )
56 Effect of proprioceptive neuromuscular facilitation combined with inspiratory muscle training on inspiratory function in patients with subacute stroke
WU Chaoyi； WU Xiuli ；LI Xufeng ；OU Zhuocheng
Objective To investigate the effect of proprioceptive neuromuscular facilitation (PNF) technology combined with inspiratory muscle training on inspiratory function in patients with subacute stroke. Methods A total of 60 patients with subacute stroke treated in the Fifth People′s Hospital of Nanhai District, Foshan City, Guangdong Province from January to December 2021 were divided into the control group (n=26) and the observation group (n=25) by random number table method.The control group used routine inspiratory muscle training, and the observation group were treated with PNF technology intervention on the basis of the control group. Both groups continued training for 4 weeks. The inspiratory muscle function, exercise energy consumption and dyspnea were compared between the two groups. Results After training, the maximum inspiratory pressure (MIP), peak inspiratory flow rate (PIF), maximum inspiratory capacity and energy consumption of the observation group were higher than those of the control group, the Borg score of the observation group was lower than that of the control group, and the differences were statistically significant (P<0.05). Conclusion PNF technology combined with inspiratory muscle training can enhance inspiratory function, enhance exercise endurance, reduce dyspnea symptoms and promote the recovery of respiratory function in patients with subacute stroke.
2022 Vol. 29 (27): 56-58转62 [Abstract] ( 38 ) HTML (1 KB)  PDF (629 KB)  ( 111 )
59 Effect of Betahistine combined with Diphenhydramine on vertigo and its influence on hemorheology and blood lipid levels
LUO Hancheng ；ZHANG Sheng； DENG Huiying
Objective To investigate the application value of Betahistine combined with Diphenhydramine in patients with vertigo. Methods A total of 80 vertigo patients admitted to Gaozhou Hospital of Traditional Chinese Medicine from January 2020 to January 2021 were selected as the research objects and divided into the control group and the study group according to the random number table method, with 40 cases in each group. The control group was treated with Betahistine, and the study group was treated with Betahistine combined with Diphenhydramine. The recovery of vertigo symptoms, hemorheology indexes, blood lipid levels and adverse reactions were compared between the two groups. Results Before treatment, there was no significant difference in vertigo symptom score between the two groups (P>0.05).After treatment, the vertigo symptom score of the study group was higher than that of the control group, and the difference was statistically significant (P<0.05). Before treatment, there were no significant differences in plasma viscosity(PV), whole blood viscosity (WBV), platelet adhesion rate (PAR) and hematocrit (PCV) between the two groups (P>0.05). After treatment, the PV, WBV, PAR and PCV of the study group were lower than those of the control group, and the differences were statistically significant (P<0.05). Before treatment, there were no significant differences in triacylglycerol (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) and total cholesterol (TC) between the two groups (P>0.05). After treatment, the TG, LDL-C and TC of the study group were lower than those of the control group, and the HDL-C was higher than that of the control group, and the differences were statistically significant (P<0.05). There were no adverse reactions in the two groups. Conclusion Betahistine combined with Diphenhydramine can effectively relieve vertigo, improve hemorheology, and restore blood lipid levels in patients with vertigo, which is safe and reliable.
2022 Vol. 29 (27): 59-62 [Abstract] ( 33 ) HTML (1 KB)  PDF (588 KB)  ( 79 )
63 Expression analysis of thymus-dependent lymphocyte subsets and natural killer cell activity detection in patients with diffuse large B-cell lymphoma with different chemotherapy responses
LI Wenwen ；ZHOU Zhangjun
Objective To investigate the expression levels of thymus-dependent lymphocyte (T lymphocyte) subsets and natural killer (NK) cell activity in diffuse large B-cell lymphoma (DLBCL) patients with different chemotherapy responses. Methods A total of 80 DLBCL patients who received treatment in Xiamen Haicang Hospital from January 2017 to January 2021 and achieved a certain curative effect were selected as the research subjects, and they were divided into complete remission group (n=44) and partial remission group (n=36). Forty healthy subjects who underwent physical examination during the same period were selected as the control group. The differences in the detection results of T lymphocyte subsets and NK cell activity were compared between the disease group and the control group, as well as the disease group before and after chemotherapy. Results Before chemotherapy, the CD3+, CD4+, CD4+/CD8+ and NK cell activity levels in the complete remission group and the partial remission group were lower than those in the control group, and the level of CD8+ was higher than that in the control group, and the differences were statistically significant(P<0.05). After 4 cycles of chemotherapy, the CD3+, CD4+, CD4+/CD8+ and NK cell activity levels in the complete remission group were higher than those before chemotherapy and after 2 cycles of chemotherapy, and the CD8+ level was lower than those before chemotherapy and after 2 cycles of chemotherapy, the differences were statistically significant(P<0.05). There were no significant differences in CD3+, CD4+, CD8+, CD4+/CD8+and NK cell activity levels in the partial remission group before chemotherapy, after 2 and 4 cycles of chemotherapy (P>0.05). Conclusion T lymphocyte subsets and NK cell activity were significantly abnormally expressed in DLBCL patients, and their expression levels were different in response to different curative effects. The test results are helpful for evaluating the clinical curative effect of DLBCL patients and are worthy of further study.
2022 Vol. 29 (27): 63-66 [Abstract] ( 31 ) HTML (1 KB)  PDF (598 KB)  ( 38 )
67 Clinical effect of intra-articular injection of platelet-rich plasma in the treatment of knee joint osteoarthritis
HOU Zengtao ；ZHU Jinqiang ；DONG Zhiwei； XING Zhijun
Objective To investigate the clinical efficacy of intra-articular injection of platelet-rich plasma in the treatment of knee joint osteoarthritis. Methods A total of 90 patients with knee joint osteoarthritis who were admitted to Qingdao Traditional Chinese Medicine Hospital from July 2018 to July 2021 were selected, and 90 patients were randomly divided into study group and control group by random number table method, 45 patients in each group. The study group was given intra-articular injection of platelet-rich plasma, and the control group was given intra-articular injection of Sodium Hyaluronate. The clinical effect, knee joint function (Lysholm) score and pain visual analog scale(VAS) score were statistically compared between the two groups. Results The total effective rate of the study group(93.33% [42/45]) was higher than that of the control group (75.55% [34/45]), the difference was statistically significant(P＜0.05). At 1 week, 1 month, 2 months and 3 months after treatment, the VAS score of the study group were lower than those of the control group, and the differences were statistically significant (P＜0.05). At 1 week, 1 month, 2 months,3 months after treatment, the Lysholm score in the study group were higher than those in the control group, and the differences were statistically significant (P＜0.05). Conclusion Intra-articular injection of platelet-rich plasma in the treatment of knee joint osteoarthritis has good clinical effects and few adverse reactions, and has important clinical significance for the treatment of patients with knee joint osteoarthritis.
2022 Vol. 29 (27): 67-69转73 [Abstract] ( 39 ) HTML (1 KB)  PDF (576 KB)  ( 135 )
70 Application of oblique lumbar interbody fusion combined with posterior approach screw-rod system in lumbar spondylolisthesis
WANG Yuehua；ZHOU Zhichun； ZHANG Lichun； SHUANG Ou
Objective To investigate the application effect of oblique lumbar interbody fusion (OLIF) combined with posterior approach screw-rod system in lumbar spondylolisthesis. Methods A total of 85 patients with lumbar spondylolisthesis in Shangrao City People′s Hospital from June 2019 to June 2021 were selected for retrospective study. According to the surgical methods, the patients were divided into 40 cases in the nail rod group and 45 cases in the combined group. The nail rod group was treated with posterior intervertebral fusion and nail rod system, and the combined group was treated with OLIF combined with approach screw-rod system. The intraoperative blood loss, operation time,postoperative infection rate, symptom relief rate, lumbar fusion rate and length of hospital stay were compared between the two groups. Results There was no significant difference in the intraoperative infection rate between the two groups(P＞0.05). The operation time of the combined group was longer than that of the nail rod group, but the intraoperative blood output of the combined group was less than that of the nail rod group, the differences were statistically significant(P＜0.05). The remission rate of symptoms in the combined group was higher than that in the nail rod group, the difference was statistically significant (P＜0.05). The lumbar fusion rate of the combined group was higher than that of the nail rod group, and the length of hospital stay of the combined group was lower than that of the nail rod group, the differences were statistically significant (P＜0.05). Conclusion OLIF combined with posterior approach screw-rod system in the treatment of patients with lumbar spondylolisthesis can reduce intraoperative blood loss, shorten the operation time, improve symptoms, and promote bone graft fusion and postoperative recovery.
2022 Vol. 29 (27): 70-73 [Abstract] ( 30 ) HTML (1 KB)  PDF (561 KB)  ( 2099 )
74 Clinical effect of meridian beating combined with acupoint massage on prevention of lower extremity deep venous thrombosis in patients with paraplegia
XIE Guiyu ；LIU Fan ；WEN Yi ；ZOU Lingjing
Objective To explore the effect of meridian beating combined with acupoint massage on preventing the formation of lower extremity deep venous thrombosis (DVT) in patients with paraplegia. Methods A total of 136 patients with paraplegia hospitalized in Department of Spinal Surgery of Foshan Hospital of Traditional Chinese Medicine from March 2020 to December 2021 were selected as research objects, they were divided into observation group and control group according to random number table method, with 68 cases in each group. The control group received routine prevention and intervention such as lower extremity position management, and the observation group was given meridian beating combined with acupoint massage on the basis of the control group.The clinical symptoms(skin color,limb swelling degree [lower extremity circumference change], pain score [numeric rating scale], Homan′s sign positive rate), plasma Ddimer (D-D) level and lower extremity vascular color Doppler ultrasound (femoral vein blood flow velocity) were recorded before intervention and after 1 week of intervention. Results Before intervention, there were no statistical differences in the skin color score, swelling degree score, pain score, Homan′s sign positive rate and serum D-D level between the two groups (P>0.05). After 1 week of intervention, the skin color score, swelling degree score, pain score and level of serum D-D in the two groups were lower than those before intervention, and the skin color score, swelling degree score, pain score and level of serum D-D of observation group were lower than those of control group, the differences were statistically significant (P<0.05). After 1 week of intervention, the Homan′s sign positive rates in the two groups were higher than those before intervention, the Homan′s sign positive rate in observation group was lower than those in the control group, the differences were statistically significant (P<0.05). There was no statistically significance in lower extremity femoral vein blood flow velocity between the two groups before intervention (P>0.05). The limb lower extremity femoral vein blood flow velocity of the two groups after 1 week of intervention were higher than those before intervention, and the limb lower extremity femoral vein blood flow velocity of observation group was higher than that of control group, the differences were statistically significant (P<0.05). Conclusion Meridian beating combined with acupoint massage can effectively increase the lower extremity blood flow velocity, relieve the clinical symptoms,and reduce the formation of DVT in patients with paraplegia, and it has certain clinical value.
2022 Vol. 29 (27): 74-77 [Abstract] ( 33 ) HTML (1 KB)  PDF (609 KB)  ( 37 )
78 Therapeutic effect of bilateral decompression via a unilateral approach technique on lumbar degenerative disc disease
CHEN Zhanpeng ；HU Yishan； LIU Weijun； LIN Mianlong； LIN Bendan
Objective To compare the clinical effect and imaging results of bilateral decompression via a unilateral approach technique and transforaminal lumbar interbody fusion in the treatment of senile lumbar degenerative disc disease. Methods A total of 60 patients with senile lumbar degenerative disc disease who underwent surgery in the Department of Orthopaedics, Shantou Central Hospital from January 2017 to April 2020 were retrospectively selected as research objects. According to different surgical methods, they were divided into bilateral decompression via a unilateral approach (BDUA) group and transforaminal lumbar interbody fusion (TLIF) group, with 30 cases in each group. Operation-related complications, the operation time, intraoperative blood loss, drainage volume, hospital stay and other indicators were compared between the two groups. The preoperative and postoperative Japan Orthopedic Association(JOA), visual analogue scale (VAS) and Oswestry disability index (ODI) scores were compared between the two groups.The fusion rate at 3 months after operation was compared between the two groups. Results The intraoperative blood loss, postoperative drainage volume in the BUDA group were less than those in TLIF group, and VAS score at 3 months after operation in the BUDA group was lower than that in the TLIF group, the differences were statistically significant(P<0.05). There were no significant differences in JOA score and ODI score between the two groups before and after operation (P>0.05). There were no significant differences in fusion rate and lumbar lordosis between the two groups after operation (P>0.05). The fusion rate and lumbar lordosis at 6, 12 months after operation in the two groups were higher than those at 3 month after operation, the differences were statistically significant (P<0.05). Conclusion Bilateral decompression via a unilateral approach has more advantages in reducing intraoperative blood loss, postoperative drainage volume and early postoperative pain.
2022 Vol. 29 (27): 78-82 [Abstract] ( 33 ) HTML (1 KB)  PDF (627 KB)  ( 86 )
83 Effect of Zhengqing Fengtongning acupoint injection combined with directional penetrating drug in the treatment of low back pain with osteoporosis and its influence on the pain level and pain mediators of patients
LIU Fan； ZHANG Hongli
Objective To investigate the effect of Zhengqing Fengtongning acupoint injection combined with directional penetrating drug in the treatment of low back pain with osteoporosis and its influence on the pain level and pain mediators of patients. Methods A total of 92 patients with osteoporosis and low back pain from September 2020 to August 2021 in the Yangluo District of the Third People′s Hospital of Hubei Province were selected as the research subjects.They were randomly divided into the treatment group (46 cases) and the control group (46 cases) by ball-touching method. The control group received conventional Western medicine, and the treatment group received Zhengqing Fengtongning acupoint injection combined with directional drug penetrating therapy. The clinical efficacy, pain degree and levels of pain mediators were compared between the two groups. Results The total effective rate of the treatment group was 91.30%, which was higher than that of the control group (76.09%), and the difference was statistically significant(P＜0.05). The scores of visual analogue scale (VAS) of the two groups after treatment were lower than those before treatment, and the VAS score of the treatment group after treatment was lower than that of the control group, and the differences were statistically significant (P＜0.05). The levels of nitric oxide (NO) in the two groups after treatment were lower than those before treatment, and the level of NO in the treatment group after treatment was lower than that in the control group, and the differences were statistically significant (P＜0.05). Conclusion Zhengqing Fengtongning acupoint injection combined with directional penetrating drug can improve clinical efficacy, relieve pain and regulate the level of pain mediator in patients with osteoporosis and low back pain.
2022 Vol. 29 (27): 83-85 [Abstract] ( 31 ) HTML (1 KB)  PDF (551 KB)  ( 101 )
86 Clinical effect of breast conserving surgery and modified radical mastectomy in patients with early breast cancer and their influence of quality of life
FAN Renyan； LIU Qiaozhen
Objective To investigate the clinical effect of breast conserving surgery and modified radical mastectomy in patients with early breast cancer and their influence of quality of life. Methods A total of 80 patients with early breast cancer admitted and diagnosed in the third People′s Hospital of Jiujiang City in Jiangxi Province from January to December 2019 were selected as the subjects for prospective analysis. They were divided into the observation group (40 cases) and the control group (40 cases) according to the random number table method. Breast conserving surgery was used in the observation group, and modified radical mastectomy was used in the control group. The operation time, intraoperative blood loss, hospitalization time, patients′ satisfaction with the cosmetic effect of breast surgery and the quality of life scores before and half a year after the operation were compared between the two groups. Results The operation time and hospitalization time of the patients in the observation group were shorter than those in the control group, and the intraoperative bleeding volume in the observation group was less than that in the control group, the differences were statistically significant (P＜0.05). The degree of effect satisfaction of the observation group was 97.5%, which was higher than that of the control group (72.5%), the difference was statistically significant (P＜0.05). There was no significant difference in preoperative quality of life score between the two groups (P＞0.05). The quality of life score in the observation group after surgery was higher than that in the control group, the difference was statistically significant (P＜0.05). Conclusion Compared with modified radical mastectomy, breast conserving surgery for patients with early breast cancer has better application effect and satisfaction. The patients have more advantages in the operation process and recovery indicators, and the quality of life of patients after operation is guaranteed, which has high application value.
2022 Vol. 29 (27): 86-89 [Abstract] ( 30 ) HTML (1 KB)  PDF (384 KB)  ( 197 )
90 Effect of thoracoscopic radical resection of lung cancer on postoperative stress response in patients with recurrent lung cancer
WU Kai
Objective To investigate the application effect of thoracoscopic radical resection of lung cancer in postoperative stress response in patients with recurrent lung cancer. Methods A total of 80 patients with recurrent lung cancer who visited the Department of Cardiothoracic Thyroid and Breast Surgery of Jianghan Oilfield General Hospital in Hubei Province from February 2019 to January 2020 were selected as the research objects, and they were divided into the control group (40 cases) and the experimental group (40 cases) according to random number table method. The patients in the control group were treated with traditional thoracotomy, and the patients in the experimental group were treated with thoracoscopic radical resection of lung cancer. The stress response indicators and inflammatory reaction indexes of the two groups were compared, and the surgical indexes and clinical treatment effects of the two groups were recorded. Results The levels of cortisol, growth hormone and prostaglandin E2 in the stress response indexes of the experimental group after treatment were lower than those of the control group after treatment, and the differences were statistically significant (P＜0.05). After treatment, the levels of C-reactive protein (CPR), procalcitonin (PCT) and interleukin-6 (IL-6) in the inflammatory response indexes in the experimental group were lower than those in the control group after treatment, and the differences were statistically significant (P＜0.05). The treatment total effective rate of the experimental group after treatment was higher than that of the control group after treatment, and the difference was statistically significant (P＜0.05). The indwelling time of the chest tube in the experimental group was shorter than that in the control group, and the difference was statistically significant (P＜0.05). Conclusion Thoracoscopic radical resection of lung cancer as the main regimen in the treatment of recurrent lung cancer can significantly improve the therapeutic effect and safety of patients, shorten the indwelling time of thoracic tube, optimize stress and inflammatory response, and it can be popularized and applied in clinical practice.
2022 Vol. 29 (27): 90-92转96 [Abstract] ( 30 ) HTML (1 KB)  PDF (775 KB)  ( 48 )
93 Application effect of Xiao′er Feireqing Granules in children with bronchopneumonia
XU Han；ZHANG Fan；ZHU Chunhui
Objective To investigate the application effect of Xiao′er Feireqing Granules in children with bronchopneumonia. Methods From October 2020 to December 2021, 84 children with bronchialpneumonia with phlegm and heat obstructing lung treated in Jiangxi Children′s Hospital were selected as the study subjects. They were divided into observation group (42 cases) and control group (42 cases) by random number table method. The control group was treated with conventional symptomatic basic treatment, and the observation group was treated with Xiao′er Feireqing Granules. The clinical efficacy, traditional Chinese medicine syndromes scores and the levels of white blood cells, neutrophils, monocytes and lymphocytes in peripheral blood were compared between the two groups, and the occurrence of adverse reactions were compared between the two groups. Results The total effective rate in the observation group was higher than that in the control group after 5 days of treatment, and the difference was statistically significant (P<0.05).After 5 days of treatment, the scores of traditional Chinese medicine syndromes in both groups were lower than those before treatment, and the differences were statistically significant (P<0.05). The score of throat phlegm/expectoration traditional Chinese medicine syndromes in the observation group was lower than that in the control group, and the difference was statistically significant (P<0.05). After 5 days of treatment, the levels of white blood cells, neutrophils and monocytes in both groups were lower than those before treatment, and the differences were statistically significant (P<0.05). The level of neutrophils in observation group was higher than that in control group, and the difference was statistically significant (P<0.05). There were no adverse reactions in both groups during treatment. Conclusion The treatment of children with bronchopneumonia with Xiao′er Feireqing Granules can regulate the immune level of the body, improve the traditional Chinese medicine syndrome of the patients, improve the total effective rate of clinical treatment, and the safety during the treatment is good.
2022 Vol. 29 (27): 93-96 [Abstract] ( 32 ) HTML (1 KB)  PDF (644 KB)  ( 57 )
97 Application effect of low-frequency pulsed electric therapy combined with breast acupoint massage in postpartum lactation and breast pain
WU Huiping
Objective To explore the application effect of low-frequency pulsed electric therapy combined with breast acupoint massage in postpartum lactation and breast pain. Methods From January 2019 to June 2021, 120 pregnant women with singleton pregnancy who were diagnosed and treated in Jingdezhen Traditional Chinese Medicine Hospital were selected as the research objects, and they were divided into the research group (60 cases) and the comparison group (60 cases) by random drawing. The patients in the research group were treated with breast acupoint massage combined with low-frequency pulsed electricity for lactation, while the patients in the comparison group were treated with conventional massage for lactation. The breast tenderness score, lactation effect and serum sex hormone levels were compared between the two groups. Results The total effective rate of lactation after treatment in the research group was higher than that in the comparison group, and the difference was statistically significant (P<0.05). The scores of breast pain after 2, 3 and 4 days of delivery in the research group were lower than those in the comparison group,and the differences were statistically significant (P<0.05). The serum prolactin level in the research group was higher than that in the comparison group at 3 days after delivery, while the estradiol level was lower than that in the comparison group, and the differences were statistically significant (P<0.05). Conclusion Breast acupoint massage combined with low-frequency pulsed electricity can effectively promote postpartum lactation, relieve breast tenderness and pain, and improve maternal serum prolactin and estradiol levels.
2022 Vol. 29 (27): 97-99转103 [Abstract] ( 34 ) HTML (1 KB)  PDF (625 KB)  ( 73 )
100 Efficacy of Ethinyl Estradiol Cyproterone Tablets combined with levonorgestrel-releasing intrauterine system in the treatment of ovulatory abnormal uterine bleeding
LUO Chunyan； XIA Qiao；CHEN Hong
Objective To investigate the effect of Ethinyl Estradiol Cyproterone Tablets combined with levonorgestrelreleasing intrauterine system (LNG-Ius) in the treatment of ovulatory abnormal uterine bleeding. Methods From January 2019 to January 2021, 160 patients with ovulatory abnormal uterine bleeding who were admitted to the Department of Obstetrics and Gynecology of Ji′an Central People′s Hospital were selected as the research objects, they were divided into the control group (80 cases) and the observation group (80 cases) according to the random number table method.The control group was treated with LNG-Ius, and the observation group was treated with Ethinyl Estradiol Cyproterone Tablets combined with LNG-Ius. The clinical treatment effect, menstrual blood loss score and sex hormone levels were compared between the two groups. Results The total effective rate of clinical treatment in the observation group after treatment was higher than that in the control group, and the difference was statistically significant (P<0.05). There was no significant difference in the menstrual blood loss score between the two groups before treatment (P>0.05). The menstrual blood loss score in the observation group after treatment was lower than that in the control group, and the difference was statistically significant (P<0.05). Before treatment, there were no statistical differences in the levels of estradiol (E2), luteinizing hormone (LH) and follicle-stimulating hormone (FSH) between the two groups (P>0.05). After treatment, the E2, LH and FSH levels of the observation group were lower than those of the control group, and the differences were statistically significant (P<0.05). Conclusion For patients with ovulatory abnormal uterine bleeding, the combination of Ethinyl Estradiol Cyproterone Tablets combined with LNG-Ius has a better therapeutic effect, which can effectively improve the level of sex hormones and is conducive to the recovery of the patients′ condition.
2022 Vol. 29 (27): 100-103 [Abstract] ( 30 ) HTML (1 KB)  PDF (615 KB)  ( 69 )
104 Effect of Iron Dextran combined with erythropoietin on the levels of reticulocyte and hepcidin-25 in patients with iron deficiency anemia during pregnancy
ZHONG Li ；ZHANG Ge
Objective To explore the application effect of Iron Dextran combined with erythropoietin (EPO) on the levels of reticulocyte (RET) and hepcidin-25 in patients with iron deficiency anemia during pregnancy. Methods A total of 80 pregnant women with iron deficiency anemia during pregnancy who were treated in Shangrao People′s Hospital between July and December 2021 were selected as the research subjects, and they were divided into observation group(40 cases) and control group (40 cases) by random number table method. The patients in the control group were treated with EPO, while the patients in the observation group were additionally given Iron Dextran on the basis of the control group. The anemia-related indicators, including hemoglobin (Hb), mean corpuscular volume (MCV) and EPO levels were observed and compared between the two groups. Serum iron related indexes, including ferritin (SF) level, hepcidin-25, membrane transporter 1 (FPN1), hemojuvelin (HJV) level and soluble transferrin receptor (sTfR) level were compared between the two groups. Hematological indexes, including RET count, mature RET ratio (MFR), immature RET fraction (IRF), low fluorescence RET ratio (LFR) and hemoglobin content (RET-He) were compared between the two groups. Results Before treatment, there were no significant differences in the levels of Hb, MCV, EPO, SF, sTfR,hepcidin-25, FPN1, HJV, RET, MFR, IRF, LFR and RET-He between the two groups (P>0.05). After 1 month of treatment, the levels of Hb and MCV in the observation group were higher than those in the control group, and the level of EPO in the observation group was lower than that in the control group, and the differences were statistically significant(P<0.05). After 1 month of treatment, the levels of SF, hepcidin-25 and HJV in the observation group were higher than those in the control group, and the levels of sTfR and FPN1 in the observation group were lower than those in the control group, and the differences were statistically significant (P<0.05). After 1 month of treatment, the levels of RET,MFR and IRF in the observation group were lower than those in the control group, and the levels of LFR and RET-He in the observation group were higher than those in the control group, and the differences were statistically significant (P<0.05). Conclusion The application of Iron Dextran combined with EPO in the treatment of patients with iron deficiency anemia during pregnancy can inhibit the abnormal expression of RET and hepcidin-25 levels, which can effectively improve the anemia status of patients.
2022 Vol. 29 (27): 104-107 [Abstract] ( 36 ) HTML (1 KB)  PDF (630 KB)  ( 92 )
108 Application effect of Ethinylestradiol Cyproterone Tablets combined with Insulin Sensitizer on ovulation induction in polycystic ovary syndrome
ZHAO Yan； LI Chenxia
Objective To explore the ovulation induction after the treatment of polycystic ovary syndrome with Eynestradiol Cyproterone Tablets combined with Insulin Sensitizer. Methods A total of 100 cases of polycystic ovary syndrome patients admitted to the Department of Obstetrics and Gynecology of Beijing Normal University Hospital from December 2018 to December 2019 were selected as research objects, according to random number table method, they were divided into control group (received Ethinylestradiol Cyproterone Tablets therapy) and study group (combined with Insulin Sensitizer on the basis of control group), with 50 cases in each group. Body mass index (BMI), waist-hip ratio(WHR), body weight, endometrial development, incidence of dominant follicles, incidence of ovarian hyperstimulation syndrome and pregnancy rate were compared between the two groups before and after treatment. Results Before treatment, there were no significant differences in BMI, WHR and body weight between the two groups (P>0.05). After treatment, the BMI, WHR and body weight of two groups were lower than those before treatment, and the BMI, WHR and body weight in the study group were lower than those in the control group, the differences were statistically significant(P<0.05). The endometrial development, incidence of dominant follicles and pregnancy rate in the study group were higher than those in the control group, and the incidence of ovarian hyperstimulation syndrome in the study group was lower than that in the control group, the differences were statistically significant (P<0.05). Conclusion For the treatment of polycystic ovary syndrome, the combination of Eynestradiol Cyproterone Tablets and Insulin Sensitizer can adjust the patients′ menstrual cycle, improve endocrine and metabolic disorders, the ovulation rate and pregnancy rate,which is worthy of clinical promotion and application.
2022 Vol. 29 (27): 108-110 [Abstract] ( 33 ) HTML (1 KB)  PDF (608 KB)  ( 26 )
111 Analysis of risk factors of emergence agitation in children undergoing inguinal hernia surgery under general anesthesia
LI Huihui
Objective To investigate the related risk factors of emergence agitation (EA) in children undergoing inguinal hernia surgery under general anesthesia. Methods A total of 142 children with inguinal hernia who underwent general anesthesia surgery in Wujiang District Children′s Hospital from November 2020 to October 2021 were selected as the research objects by cluster sampling. The data of children were collected and sorted, and the risk factors of EA in children undergoing inguinal hernia surgery under general anesthesia were analyzed. Results The incidence of EA in children undergoing inguinal hernia surgery under general anesthesia was 21.83% (31/142). Univariate analysis showed that in the EA group, the proportions of age≤6 years old, preoperative anxiety, postoperative pain level>4 points and indwelling catheters were higher than those of the non EA group, the differences were statistically significant (P<0.05).There were no significant differences in gender, operation time, operation method, recovery time, operation history, and American Society of Anesthesiologists (ASA) grade between the two groups (P>0.05). Multiple factors analysis showed that age≤6 years old (β=0.870, OR=2.386, 95%CI=1.045-5.451), preoperative anxiety (β=1.054, OR=2.870, 95%CI=1.269-6.491), postoperative pain degree>4 points (β=1.319, OR=3.738, 95%CI=1.635-8.550), indwelling catheter (β=1.148, OR=3.151, 95%CI=1.356-7.322) were independent risk factors of EA in children udergoing inguinal hernia surgery under general anesthesia (P<0.05). Conclusion The incidence of EA in children undergoing inguinal hernia surgery with anesthesia is high, and its occurrence is related to age, preoperative anxiety, postoperative pain degree and indwelling catheter.
2022 Vol. 29 (27): 111-113转117 [Abstract] ( 31 ) HTML (1 KB)  PDF (628 KB)  ( 100 )
114 Contraceptive efficacy and safety comparison between intrauterine device placement and oral contraceptives after induced abortion
ZHOU Juanjuan
Objective To investigate the contraceptive effect and safety of two methods of placing intrauterine device and oral contraceptives after induced abortion. Methods A total of 116 patients with induced abortion who were admitted to the Department of Obstetrics and Gynecology of Xishan People′s Hospital in Wuxi City from September 2019 to September 2021 were selected as the research objects, and divided into the experimental group (51 cases) and the control group (65 cases) according to the patients′ wishes. The levonorgestrel-releasing intrauterine system (Mirena) was placed in the experimental group after operation, and the oral contraceptive was used in the control group. The intervention effects of the two groups were compared. Results There was no significant difference in the rate of contraceptive failure between the two groups (P>0.05). The duration of postoperative bleeding in the experimental group was lower than that in the control group, and the difference was statistically significant (P<0.05). The correct usage rate of experimental group was higher than that of control group, and the difference was statistically significant (P<0.05). The total incidence of adverse reactions in experimental group was lower than that in control group, and the difference was statistically significant (P<0.05). Conclusion After artificial abortion, both Mirena and oral contraceptives can achieve the ideal contraceptive effect, but the safety of Mirena is relatively high, worthy of clinical reference.
2022 Vol. 29 (27): 114-117 [Abstract] ( 56 ) HTML (1 KB)  PDF (614 KB)  ( 100 )
118 Effect of Probiotics assisted Minocycline Hydrochloride in patients with moderate chronic periodontitis
ZOU Juan ZENG Zhimei
Objective To explore the effect of Probiotic assisted Minocycline Hydrochloride on moderate chronic periodontitis. Methods A total of 90 patients with moderate chronic periodontitis admitted to Maternal and Child Health Care Hospital of Ganzhou City from April 2021 to March 2022 were selected as the research objects and divided into control group and observation group according to the random number table method, with 45 cases in each group. The control group were treated with Minocycline Hydrochloride, the observation group were treated with Probiotic assisted Minocycline Hydrochloride. The clinical treatment effect, oral health (scores of oral health assessment tool [OHAT],clinical attachment loss [CAL], gingival index [GI], probing depth [PD], plaque index [PLI], sulcus bleeding index[SBI])and local inflammatory reaction indexes (gingival crevicular fluid tumor necrosis factor-α [TNF-α], interleukin-6 [IL-6]and interleukin-8 [IL-8]) before and after treatment were compared between the two groups. Results The total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant(P<0.05). There was no significant difference in OHAT score between the two groups before treatment (P>0.05). The OHAT score of the observation group after treatment was lower than that of the control group, and the difference was statistically significant (P<0.05). Before treatment, there was no significant difference in CAL, GI, PD, PLI and SBI between the two groups (P>0.05). After treatment, CAL, GI, PD, PLI and SBI in the observation group were lower than those in the control group, and the differences were statistically significant (P<0.05). Before treatment, there was no significant difference in gingival crevicular fluid inflammation index between the two groups (P>0.05). After treatment,the levels of TNF-α, IL-6 and IL-8 in the observation group were lower than those in the control group, and the differences were statistically significant (P<0.05). Conclusion The application effect of Probiotic assisted Minocycline Hydrochloride in patients with chronic periodontitis is better, and it can significantly improve the oral health and local inflammatory reaction, so its application value in the patients with chronic periodontitis is higher.
2022 Vol. 29 (27): 118-121转125 [Abstract] ( 31 ) HTML (1 KB)  PDF (466 KB)  ( 78 )
122 Effect of drug-induced pupil dilation on intraocular lens power calculation in cataract patients
LIU Kai；ZHANG Hua
Objective To investigate the effect of mydriasis on ocular parameters measured by optical biometrics and intraocular lens power calculation. Methods A total of 27 cataract patients admitted to Jingde Eye Hospital of Texas from December 13 to 19, 2021 were selected as the research objects. Optical biometry was performed without mydriasis and mydriasis, axial length (AL), anterior chamber depth (ACD) and anterior corneal surface curvature were recorded.The posterior chamber intraocular lens (IOL) degrees before and after mydriasis were calculated by SRK/T and Haigis formulas respectively. Results The ACD before mydriasis was lower than that after mydriasis, the difference was statistically significant (P＜0.05). There was no significant difference in AL before and after mydriasis (P>0.05). There was no significant difference in flat K (FK) and steep K (SK) between pre-and post-mydriasis (P>0.05). There was no significant difference in IOL values calculated by SRK/T formula and Haigis formula between pre-and post-mydriasis (P>0.05). Conclusion Drug-induced mydriasis has no significant effect on the diopter value of posterior chamber IOL calculated by SRK/T formula and Haigis formula, but it significantly affects the intraocular ACD value measured by optical biometric method.
2022 Vol. 29 (27): 122-125 [Abstract] ( 33 ) HTML (1 KB)  PDF (444 KB)  ( 34 )
126 Application effect of one-time root canal therapy in dental pulp disease
ZHANG Qian
Objective To investigate the application effect of one-time root canal therapy in dental pulp disease. Methods From May 2019 to December 2020, 64 patients with dental pulp disease admitted to the Department of Stomatology,Shuyang Hospital were selected as the research objects. They were divided into observation group (32 cases, 37 teeth)and control group (32 cases, 36 teeth) by random number table method. The observation group received one-time root canal treatment, and the control group received multiple root canal treatment. The total effective rate, pain, changes of inflammatory factors and complications were compared between the two groups. Results The total effective rate of the observation group was 96.87%, which was higher than 78.13% of the control group, and the difference was statistically significant (P<0.05). The visual analogue scale (VAS) score of pain 1 day, 1 week and 1 month after treatment in the observation group were lower than those in the control group, and the differences were statistically significant (P<0.05).The levels of C-reactive protein (CRP) and interleukin-6 (IL-6) in the observation group after treatment were lower than those in the control group, and the differences were statistically significant (P<0.05). The total incidence of complications in the observation group was 6.26%, which was lower than 28.14% in the control group, and the difference was statistically significant (P<0.05). Conclusion One-time root canal therapy for patients with dental pulp disease can promote the improvement of the total effective rate of treatment, and plays an important role in relieving pain sensation and reducing inflammatory factor indicators, and has fewer complications and is more effective. security,so it is worthy of popular use.
2022 Vol. 29 (27): 126-129 [Abstract] ( 29 ) HTML (1 KB)  PDF (443 KB)  ( 81 )
130 Active monitoring analysis of Xueshuantong for Injection was carried out based on hospital pharmacovigilance system
SONG Yuanyuan；LI Heng
Objective To actively monitor the clinical application of Xueshuantong for Injection and make comprehensive evaluation, so as to provide reference for clinical safe and rational drug use and improve the drug instructions.Methods A total of 1 688 patients who were hospitalized and used Xueshuantong for Injection from January to December 2019 in Lianyungang Chinese Medicine Hospital were actively monitored based on the pharmacovigilance system of hospital information system (HIS) sentinel hospital pharmacovigilance system. The basic information of patients, drug use information, occurrence of adverse drug reactions (ADR) and rationality of drug use were statistically analyzed. Results The average age of monitored patients was (63.08±18.86) years old, and the male to female ratio was 1∶1.07. The main reasons were cerebrovascular disease, orthopedic disease, kidney disease, etc. It was used in 84.21% of clinical departments in the hospital. The average course of treatment was (8.00±5.28) d, the daily dose ranged from 150-600 mg/time, and all the drugs were administered intravenously once a day. The solvent mainly used 0.9% Sodium Chloride Injection (92.42%). The number of combined drug varieties was 130. ADR occurred in 7 cases (0.41%),mainly manifested as skin and accessory damage. Irrational drug use was mainly manifested in over-indication drug use, long duration of drug treatment, inappropriate choice of solvent and combined use of drugs with similar efficacy.Conclusion Clinical pharmacists actively monitored Xueshuantong for Injection based on the pharmacovigilance system of sentinel hospitals, and evaluated its rationality in clinical application and the occurrence of adverse reactions. Most of the patients were elderly, and the number of combined drugs was large, and there were repeated drugs. The occurrence of ADR was related to age, combined medication and so on. Clinical pharmacists should strengthen medication monitoring of patients and guide clinicians to use drugs safely and rationally.
2022 Vol. 29 (27): 130-133 [Abstract] ( 33 ) HTML (1 KB)  PDF (470 KB)  ( 101 )
134 Relationship between the typical clinical features of polycystic ovary syndrome and self-esteem and body image satisfaction
XU Li；SONG Xiaoyan；WANG Xingge； LIU Honghui；YU Jing；LI Zhenyu；LI Jia
Objective To analyze the influencing factors of self-esteem and body image satisfaction in polycystic ovary syndrome (PCOS). Methods A total of 290 female patients with PCOS in the People′s Hospital of Liaoning Province from October 2020 to December 2021 were selected as research objects, analyze the influencing factors of patients′self-esteem and body image satisfaction. Results The univariate analysis showed that there were significant differences in polyhairy, acne, pregnancy, BMI in self-esteem and body image (P＜0.01). The results of the multiple linear regression analysis showed that, polyhairy (β=-0.12, P＜0.01), acne (β=-0.37, P＜0.01), reproductive situation (β=0.29, P＜0.01), and BMI (β=-0.16, P＜0.01) were factors affecting low self-esteem in women with PCOS. Acne (β=0.40, P＜0.01),reproductive situation (β=-0.26, P＜0.01), and BMI (β=0.17, P＜0.01) were factors influencing body image in women with polycystic ovary syndrome. Conclusion Through this study, medical staff can fully understand the related factors of low self-esteem and poor body image satisfaction of women with polycystic ovary syndrome, and help patients improve their weight, menstrual disorders, hairy and infertility symptoms. It provides a diversified method to improve the clinical practice effect and the management of women with polycystic ovary syndrome.
2022 Vol. 29 (27): 134-137 [Abstract] ( 31 ) HTML (1 KB)  PDF (468 KB)  ( 53 )
138 Application effect of health education model mediated by Plan-Do-Check-Action mode in Parkinson disease patients
LI Jingchao； LI Xiaoping； JIANG Meiling ；XU Jia
Objective To explore the application effect of health education model mediated by Plan-Do-Check-Action(PDCA) mode in Parkinson disease patients. Methods A total of 48 patients with Parkinson′s disease who were admitted to the Second Department of Neurology, Hongqi Hospital Affiliated to Mudanjiang Medical College from September 2019 to September 2021 were selected as the research objects, and they were divided into the control group (24 cases)and the observation group (24 cases) by random number table method. The control group adopted the conventional education model, and the observation group adopted the PDCA-mediated health education model. The cognitive function,quality of life and sleep index of the two groups were compared. Results Before intervention, there was no significant difference in Montreal cognitive scale (MoCA) score between the two groups (P>0.05). After intervention, the MoCA scores of the two groups were higher than those before intervention, and the differences were statistically significant (P<0.05). After intervention, the MoCA score of the observation group was higher than that of the control group, and the difference was statistically significant (P<0.05). Before intervention, there were no significant differences in the scores of the comprehensive assessment of quality of life (GQOLI-74) between the two groups (P>0.05). After intervention, the GQOLI-74 scores of the two groups were higher than those before intervention, and the GQOLI-74 score of the observation group was higher than that of the control group, and the differences were statistically significant (P<0.05). Before intervention,there was no significant difference in the Pittsburgh sleep quality index (PSQI)score between the two groups(P>0.05). After intervention, the PSQI score of the two groups was higher than that before intervention, and the difference was statistically significant (P<0.05). After intervention, the PSQI score of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).Conclusion The PDCA-mediated health education model has a positive effect on the improvement of the quality of life of Parkinson disease patients.
2022 Vol. 29 (27): 138-140转148 [Abstract] ( 31 ) HTML (1 KB)  PDF (654 KB)  ( 34 )
141 Influence of health education on self-management ability in non-know ledge-based elderly patients with maintenance hemodialysis in a solutionfocused mode
HE Lili
Objective To explore the effect of health education under the solution-focused mode on the selfmanagement ability of non-knowledge-based elderly patients with maintenance hemodialysis. Methods From March 2020 to March 2021, 114 elderly patients undergoing maintenance hemodialysis in Guangshui Second People′s Hospital were selected as the research subjects, and randomly divided into observation group and control group (57 cases in each group). In the control group, routine health education was used, and in the observation group, health education under the focus-solution mode was additionally provided. The mastery of health knowledge such as disease knowledge,dietary principles, medication methods, complication prevention knowledge, and self-care methods between the two groups was compared. The self-management ability scores including medical compliance, reasonable diet and exercise,medication compliance, and correct nursing of internal fistula and renal functions such as blood urea nitrogen (BUN),albumin (ALB), and serum creatinine (SCr) before intervention and 3 months after intervention of the two group were compared. Results The scores of disease knowledge, dietary principles, medication methods, complication prevention knowledge and self-care methods in the observation group were higher than those in the control group,and the differences were statistically significant (P<0.05). The scores of medical compliance, reasonable diet and exercise, medication compliance, and correct nursing of internal fistula in the observation group were higher than those in the control group,and the differences were statistically significant (P<0.05). There were no significant differences in the level of BUN, ALB or SCr between the two groups before intervention (P>0.05). The levels of BUN and SCr in the observation group and the control group after intervention were lower than those before intervention, and the level of ALB was higher than that in the group before intervention, the differences were statistically significant (P<0.05). After intervention, the levels of BUN and Scr in the observation group were lower than those in the control group, and the ALB level was higher than that in the control group, the differences were statistically significant (P<0.05). Conclusion Application of health education under the solution-focused mode in non-knowledge-based elderly patients with maintenance hemodialysis can effectively improve the patient’s health knowledge mastery and self-management ability, and promote the improvement of patient’s renal function.
2022 Vol. 29 (27): 141-144 [Abstract] ( 32 ) HTML (1 KB)  PDF (399 KB)  ( 29 )
145 Application effect of data quality control of medical record statistics management information system in hospital medical record management
SHEN Lihua；YANG Jing
Objective To explore the application effect of data quality control of medical record statistical management information system in hospital medical record management. Methods A total of 5 600 medical records from Putian Medical District, Joint Logistic Support Force 900th Hospital from January 2019 to August 2021 were selected and divided into the observation group and the control group according to the statistical order of medical records, with 2 800 medical records in each group. The observation group (January 2020 to August 2021) received data quality control management, while the control group (January to December 2019) received routine data management. The data entry error rate, medical record writing, progress record, hospitalization record, medical record home page, auxiliary examination and discharge record quality were compared between the two groups. Results The incidence of data entry error of medical record data in the observation group was lower than that in the control group, and the difference was statistically significant (P<0.05). The scores of medical record writing, course record, hospitalization record, medical record home page, auxiliary examination and discharge record quality evaluation in the observation group were higher than those in the control group, and the differences were statistically significant (P<0.05). Conclusion In the application of medical record statistics management information system, the implementation of data quality control management scheme can effectively reduce the incidence of data entry errors of medical record data and improve the management quality of medical record data, which is worthy of clinical application.
2022 Vol. 29 (27): 145-148 [Abstract] ( 33 ) HTML (1 KB)  PDF (392 KB)  ( 207 )
149 Application value of continuous quality improvement in health examination management
ZHAI Shihui
Objective To explore the application effect of continuous quality improvement in health examination management. Methods A total of 120 physical examination subjects who underwent physical examination in the General Hospital of the Northern Theater Command of the Chinese People′s Liberation Army from March 2019 to February 2021 were selected as the research objects, and they were divided into the control group and the observation group by time grouping method, with 60 cases in each group. Patients in the control group were enrolled from March 2019 to February 2020 and underwent routine physical examination. Patients in the observation group were enrolled from March 2020 to February 2021, and the continuous quality improvement health examination management was adopted. The physical examination time, queue-jumping, anxiety and depression scores and physical examination satisfaction were compared between the two groups. Results The physical examination time of the observation group was shorter than that of the control group, and the queue jumping rate, self-rating anxiety scale (SAS) score and self-rating depression scale (SDS) score were lower than those of the control group, and the differences were statistically significant (P<0.05).The total satisfaction rate of physical examination in the observation group was higher than that in the control group,and the difference was statistically significant (P<0.05). Conclusion The application of continuous quality improvement in the management of health check-up has a significant effect, which can effectively shorten the time required for check-up, reduce the occurrence of queue cutting, and improve the psychological state of check-ups. The clinical value is high, and it is recommended to be widely promoted.
2022 Vol. 29 (27): 149-151 [Abstract] ( 34 ) HTML (1 KB)  PDF (385 KB)  ( 56 )
152 Teaching design and strategy of preventive dentistry based on smart flipped classroom
SUN Jie
With the development of educational informatization and the continuous upgrading of intelligent teaching platform, it is very necessary for higher vocational colleges to strengthen the research on smart flipped classroom teaching mode and accelerate the normalization of smart flipped classroom teaching mode. Firstly, on the basis of clarifying the connotation and characteristics of the smart flipped classroom teaching mode, under the guidance of the concept of smart education, this paper puts forward the teaching design concept of trying to change students′ learning methods through reasonable smart flipped classroom teaching design, improve students′ classroom participation by building a "student-oriented and effective interactive" classroom, and promote students′ all-round development by making full use of information-based teaching means. Then, the smart flipped classroom teaching design is carried out for the lesson "oral cancer and its prevention" in Chapter 6 of preventive dentistry. On this basis, this paper discusses the teaching strategy of smart flipped classroom. Pay attention to the supervision of students′ autonomous learning effect before class, and give play to the role of group learning and mutual assistance. Improve the learning participation of vulnerable students in class to meet students′ personalized learning needs. After class, guide students′ deep thinking and application of classroom content, and promote the consolidation and transfer of knowledge. Finally, through analysis and comparison, it is proposed that the smart flipped classroom teaching mode has the characteristics and advantages of enabling higher vocational students to receive personalized education, enabling higher vocational teachers to truly feel the timeliness of the classroom, better grasp the classroom rhythm, manage students, and realize effective communication between teachers and students.
2022 Vol. 29 (27): 152-156 [Abstract] ( 33 ) HTML (1 KB)  PDF (522 KB)  ( 27 )
157 Application effect of PBL method combined with SEGUE framework on improving doctor-patient communication ability of orthopaedic regular training physicians
DONG Xianghui ；JIN Zhankui
Objective To explore the application effect of problem-based learning (PBL) method combined with doctorpatient communication skills evaluation scale (SEGUE) on improving the doctor-patient communication ability of orthopaedic regular training physicians. Methods From January 2020 to September 2021, 54 regular training physicians rotating in the Department of Orthopedics of Shaanxi Provincial People′s Hospital were selected as the research objects.They were divided into experimental group (27 cases) and control group (27 cases) by random draw method. The doctors in the experimental group used PBL method combined with SEGUE framework, and the doctors in the control group used traditional teaching method. The evaluation of doctor-patient communication ability of regular training physicians between the two groups′ patients at admission and exit of the department was compared. The doctor-patient communication ability self-evaluation score and SEGUE score were compared between the two groups at admission and exit of the department. Results At the time of admission, there were no significant differences in the excellent and good rate and qualified rate of the evaluation of doctor-patient communication ability between the two groups (P>0.05).There were no significant differences in self-evaluation score and SEGUE score of doctor-patient communication ability between the two groups (P>0.05). When leaving the department, the excellent and good rate of patients in the experimental group was higher than that in the control group, and the difference was statistically significant (P<0.05). When leaving the department, the excellent and good rate and qualified rate of the evaluation of doctor-patient communication ability of patients in the two groups were higher than those when entering the department, and the differences were statistically significant (P<0.05). The self-evaluation score and SEGUE score of the regular training physicians in the experimental group were higher than those in the control group, and the differences were statistically significant (P<0.05). When leaving the department, the self-evaluation score and SEGUE score of the two groups of regular training physicians were higher than those when entering the department, and the differences were statistically significant (P<0.05). Conclusion PBL method combined with SEGUE framework can significantly improve the doctor-patient communication ability of orthopaedic regular training doctors. It was recommended PBL method combined with SEGUE framework should be widely used in the clinical teaching and learning of orthopaedic regular training physicians, and the cultivation of doctor-patient communication ability should run through the whole process of medical education.
2022 Vol. 29 (27): 157-161 [Abstract] ( 32 ) HTML (1 KB)  PDF (509 KB)  ( 117 )
162 Application of flipped classroom combined with situational simulation teaching in standardized training of laboratory doctors
WANG Bingying； YANG Huan； DU Hong
Objective To analyze the application effect of flipped classroom combined with situational simulation teaching in the standardized training of laboratory doctors. Methods A total of 100 students who received standardized training for laboratory doctors in the Department of Clinical Laboratory of the Second Affiliated Hospital of Suzhou University from January 2019 to December 2021 were selected as the research objects. According to the training time, 50 students who received training from January 2019 to June 2020 were selected as the control group, the traditional teaching method of Department of Clinical Laboratory was implemented, 50 students who received training from July 2020 to December 2021 were selected as the study group, the flipped classroom combined situational simulation teaching was implemented. The learning experience, satisfaction with the teaching mode, theoretical knowledge, clinical skills and clinical comprehensive ability of the two groups were compared. Results After 4 weeks of practice, the scores of theoretical knowledge and clinical skills of the study group were higher than those of the control group, the differences were statistically significant (P<0.05). The overall performance, organizational efficiency, humanistic care, communication skills and doctor-patient communication scores of the study group were higher than those of the control group, the differences were statistically significant (P<0.05). The increase rates of ability of analysis and problem-solving, autonomous learning, learning efficiency and learning enthusiasm in the study group were higher than those in the control group, the differences were statistically significant (P<0.05). Conclusion In the standardized training and teaching of laboratory doctors, the flipped classroom combined with situational simulation teaching is helpful to improve the students′ satisfaction and clinical comprehensive ability, and make them fully grasp the professional theoretical knowledge and professional skills, which is worthy of clinical attention and application.
2022 Vol. 29 (27): 162-165 [Abstract] ( 40 ) HTML (1 KB)  PDF (520 KB)  ( 70 )
166 Clinical pharmacist′s pharmaceutical care for a child with intracranial infection complicated with epilepsy
GAO Bei；WANG Jing；GE Bin

When anti-infective drugs and anti-epileptic drugs are treated simultaneously, on the one hand, attention should be paid to the possible epileptogenic adverse reactions of antiinfective drugs, and on the other hand, attention should be paid to the interaction between antiinfective drugs and antiepileptic drugs. In this paper, clinical pharmacists provided pharmaceutical care for a child patient with intracranial infection complicated with epilepsy for many times.Including the reorganization of medical orders to analyze the cause of epilepsy in children. It is considered that the cause of poor epilepsy control may be the interaction between Meropenem and Sodium Valproate resulting in the reduction of sodium valproate plasma concentration. The clinical characteristics of the interaction were summarized by literature review. Combined with the pathophysiological characteristics of the children, the epileptogenic nature of anti-infective drugs, the adverse reactions of anti-epileptic drugs and many other factors, to assist doctors to re-formulate anti-infective and anti-epileptic treatment plans. Finally, the infection and epilepsy symptoms of children are effectively controlled. The pharmaceutical care provided by clinical pharmacists throughout the treatment of children not only ensures the safety and effectiveness of the treatment of children, but also provides a reference for the formulation of drug treatment plan for such patients.
2022 Vol. 29 (27): 166-169 [Abstract] ( 39 ) HTML (1 KB)  PDF (450 KB)  ( 123 )
170 Two case reports of hereditary spherocytosis combined with pregnancy
LI Wei ；ZHOU Liping ；KANG Suya
Hereditary spherocytosis (HS) is featured with recurrentvascular hemolyticanemia, intermittent jaundice and splenomegaly，which is the most common inherited disease with red blood cell membrane defect. The incidence rate in northern Europe and North America is up to 1/2 000. As is known to all, the disease is caused by genetic mutation that encodes the membrane protein such as SPTB. There are few cases of hereditary spherocytosis combined with pregnancy clinically. This paper reports two cases of elective term delivery in pregnant women with hereditary spherocytosis without splenectomy, and discusses the management of pregnancy complicated with hereditary spherocytosis, the timing and mode of termination of pregnancy, and the causes of anemia during pregnancy, to provide clinical basis for diagnosis and treatment of pregnancy complicated with hereditary spherocytosis in the future.
2022 Vol. 29 (27): 170-172转177 [Abstract] ( 40 ) HTML (1 KB)  PDF (798 KB)  ( 61 )
173 Application effect of health education based on feedback method in bladder cancer patients with urostomy
YIN Shuting； YE Zhenni； WANG Jun； YANG Mingying
Objective To explore the application effect of health education based on teach-back method in patients of bladder cancer with urostomy. Methods A total of 80 bladder cancer patients admitted to the Department of Urinary Surgery, the Second Affiliated Hospital of Kunming Medical University from January 2020 to September 2021 were selected as the research objects. All patients underwent radical cystectomy plus uncontrolled urinary diversion. Patients were divided into experimental group (n=40) and control group (n=40) by random number table method. The control group was given routine health education intervention, while the experimental group was given health education based on teach-back method. Three months after operation, the behavioral compliance of the two groups was assessed by the compliance questionnaire, and the self-care ability of the two groups was analyzed by the Kristensen urostomy self-care scale. The incidence of stoma and peristoma complications was recorded. Results Three months after operation, the total behavior compliance rate of the experimental group was higher than that of the control group, and the difference was statistically significant (P<0.05). Before intervention, there was no significant difference in the scores of Kristensen urostomy self-care scale between the two groups (P>0.05). After intervention, the self-care willingness, self-care skills and total score of the scale of patients in the experimental group were higher than those before intervention, and the above scores of patients in the experimental group were higher than those in the control group, and the differences were statistically significant (P<0.05). The total incidence of complications in experimental group was lower than that in control group, and the difference was statistically significant (P<0.05). Conclusion Health education based on teach-back method can eff ectively improve behavioral compliance,reduce the incidence of stoma and peristoma skin complications, and improve the self-care ability of patients of bladder cancer with urostomy.
2022 Vol. 29 (27): 173-177 [Abstract] ( 32 ) HTML (1 KB)  PDF (619 KB)  ( 94 )
178 Application effect of sequential evaluation of disease in the pre-hospital emergency care of patients with acute ischemic stroke
TENG Wei
Objective To investigate the application effect of sequential evaluation of disease in the pre-hospital emergency care of patients with acute ischemic stroke (AIS). Methods The data of 36 AIS patients who received routine nursing in pre-hospital emergency treatment in Yingtan People′s Hospital from July 2019 to June 2020 were retrospectively selected as the control group, the data of 36 AIS patients who underwent sequential evaluation in pre-hospital emergency care from july 2020 to June 2021 were selected as the observation group. The first aid effect, complications and nursing satisfaction were compared between the two groups. Results The time of pre-emergency evaluation, outof-hospital first aid, in-hospital first aid, in-hospital diagnosis and hospitalization in the observation group were shorter than those in the control group, and the differences were statistically significant (P<0.05). The total incidence of complications in the observation group was lower than that in the control group, and the difference was statistically significant(P<0.05). The total nursing satisfaction of the observation group was higher than that of the control group, and the difference was statistically significant (P<0.05). Conclusion The use of sequential assessment in pre-hospital emergency care can improve the effect of pre-hospital AIS rescue, reduce the incidence of complications, and improve nursing satisfaction, which is worthy of promotion and application.
2022 Vol. 29 (27): 178-180 [Abstract] ( 38 ) HTML (1 KB)  PDF (558 KB)  ( 175 )
181 Influence of continuous nursing based on big data platform on functional recovery and quality of life of elderly patients after total hip arthroplasty
LIU Qin ；LIU Xueping； WANG Liu
Objective To explore the influence of continuous nursing based on big data platform on improving the functional recovery and quality of life of elderly patients with total hip arthroplasty (THA). Methods A total of 80 elderly patients who underwent THA in the Department of Joint Surgery of Pingxiang People′s Hospital from January 2020 to July 2021 were selected as the research objects. They were divided into the study group and the control group by random number table method, with 40 cases in each group. Patients in the control group received routine postoperative care for THA patients, while patients in the study group received extended care based on big data platform on the basis of routine postoperative care. The fracture healing time and hospital stay of the two groups were statistically analyzed.Functional recovery (Harris hip function scale [HHS]), quality of life (activities of daily living scale [ADL]) and selfevaluation (general self-efficacy scale [GSES]) before and 6 months after intervention, and complications at 6 months after intervention were compared before intervention and 3 and 6 months after intervention. Results The fracture healing time and hospital stay of the study group were shorter than those of the control group, and the differences were statistically significant (P<0.05). Before intervention, there were no significant differences in HHS, ADL and GSES scores between the two groups (P>0.05). At 3 and 6 months after intervention, the HHS scores of patients in the two groups were higher than those before intervention, and the HHS scores of patients in the study group were higher than those in the control group, the differences were statistically significant (P<0.05). The HHS scores of the two groups at 6 months after intervention were higher than those at 3 months after intervention, and the differences were statistically significant (P<0.05). Six months after intervention, the GSES score of the study group was higher than that of the control group, and the difference was statistically significant (P<0.05). At 6 months after intervention, the ADL scores of patients in the two groups were lower than those before intervention, and the ADL scores and incidence of complications in the study group were lower than those in the control group, the differences were statistically significant (P<0.05).Conclusion Continuous nursing based on big data platform can effectively shorten the diagnosis and treatment time,promote the postoperative functional recovery, improve the postoperative quality of life and self-evaluation and reduce the occurrence of postoperative complications of elderly patients with total hip arthroplasty.
2022 Vol. 29 (27): 181-184 [Abstract] ( 31 ) HTML (1 KB)  PDF (604 KB)  ( 46 )
185 Application effect of Plan-Do-Check-Action mode in dietary nursing of children with Henoch-Schonlein purpura
LI Juan
Objective To explore the effect of Deming ring model in the nursing of children with Henoch-Schonlein purpura. Methods A total of 200 children with Henoch-Schonlein purpura treated in the Department of Pediatrics of Maternal and Child Health Hospital from July 2019 to July 2021 were selected as the research object. They were divided into observation group (n=100) and control group (n=100) by random number table method. Plan-Do-Check-Action(PDCA) circulation mode was used in the observation group, and basic nursing was used in the control group. The scores of anxiety, behavior and survival time of the two groups were compared. Results The family members in the observation group was higher understanding of disease knowledge than those in the control group, and the difference was statistically significant (P<0.05). There was no significant difference in family management score between the two groups before nursing (P>0.05). The score of family management in the observation group was higher than that in the control group, and the difference was statistically significant (P<0.05). The scores of compliance behaviors in the observation group were higher than those in the control group, and the differences were statistically significant (P<0.05).There was no significant difference in anxiety scores between the two groups before intervention (P>0.05). After the intervention, the anxiety scores of family members in the observation group were lower than those in the control group,and the differences were statistically significant (P<0.05). The regression time of rash in the observation group was shorter than that in the control group, and the difference was statistically significant (P<0.05). Conclusion The application of PDCA model in dietary nursing of children with Henoch-Schonlein purpura can improve the effect of family management and reduce the recurrence rate of the disease.
2022 Vol. 29 (27): 185-188转192 [Abstract] ( 32 ) HTML (1 KB)  PDF (630 KB)  ( 100 )
189 Clinical effect analysis of evidence-based nursing in preventing postpartum hemorrhage in cesarean section
LIU Tonghua；JIA Tiegang；LI Jingdan

Objective To explore the clinical effect of evidence-based nursing in preventing postpartum hemorrhage in cesarean section. Methods A total of 280 pregnant women who underwent cesarean section in Liangxiang Hospital,Fangshan District, Beijing from May to October 2021 were selected as research objects, and they were divided into observation group (n=140) and control group (n=140) by random number table method. The control group was given routine nursing measures, and the observation group was given evidence-based nursing intervention on the basis of routine nursing. The bleeding volume during operation, 2 h and 24 h after operation, red blood cell (RBC), hemoglobin (HGB),red blood cell volume (HCT) and complication rate before operation and 24 h after operation were compared between the two groups. Results There was no significant difference in intraoperative blood loss between the two groups (P＞0.05).Blood loss at 2 h after surgery in the observation group was significantly lower than that in the control group, with statistically significant differences (P＜0.05). In the control group, there was no significant difference in blood loss between during surgery and at 2 h after surgery (P＞0.05). But blood loss at 2 h and 24 h after surgery in the observation group were less than those in the control group, with statistically significant differences (P＜0.05). The measurement values of RBC, HGB and HCT in observation group were significantly higher than those in control group, with statistically significant differences (P＜0.05). The total incidence of postoperative complications in observation group was significantly lower than that in control group, with a statistically significant difference (P＜0.05). Conclusion Evidence-based nursing intervention can effectively reduce postpartum hemorrhage and postoperative complications of cesarean section women.
2022 Vol. 29 (27): 189-192 [Abstract] ( 28 ) HTML (1 KB)  PDF (569 KB)  ( 62 )
193 Application effect of management by objectives in elderly patients with femoral intertrochanteric fractures after surgery
WANG Mei ；LI Zhaoju ；GUO Yan′er
Objective To analyze the application effect of management by objectives (MBO) in elderly patients with femoral intertrochanteric fracture. Methods From October 2020 to October 2021, a total of 60 patients with femoral intertrochanteric fractures admitted to the Mindong Hospital of Ningde City were selected as resarch objects. The patients were divided into the experimental group and the control group, with 30 cases in each group. In the experimental group,the postoperative rehabilitation plan was designed via MBO, and in the control group, the patients′ rehabilitation plan was performed based on the conventional nursing method. The safety scores, self-efficacy, and Harris score of hip joint function of hospitalized elderly patients with femoral intertrochanteric fractures were compared between the two groups.Results The safety scores, self-efficacy, and hip Harris scores of the patients in the experimental group were higher than those in the control group, and the differences were statistically significant (P＜0.05). Conclusion MBO as an intervention is conducive to improving the sense of security, self-efficacy, and hip function of elderly patients with femoral intertrochanteric fractures after surgery, enhancing the quality of life of patients, and bringing benefits to the society and patients, and is worthy of clinical promotion.
2022 Vol. 29 (27): 193-196 [Abstract] ( 31 ) HTML (1 KB)  PDF (602 KB)  ( 80 )
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