注射用血栓通临床应用的主动监测与合理性分析

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Abstract Objective To actively monitor the clinical application of Xueshuantong for Injection and make comprehensive evaluation, so as to provide reference for clinical safe and rational drug use and improve the drug instructions.Methods A total of 1 688 patients who were hospitalized and used Xueshuantong for Injection from January to December 2019 in Lianyungang Chinese Medicine Hospital were actively monitored based on the pharmacovigilance system of hospital information system (HIS) sentinel hospital pharmacovigilance system. The basic information of patients, drug use information, occurrence of adverse drug reactions (ADR) and rationality of drug use were statistically analyzed. Results The average age of monitored patients was (63.08±18.86) years old, and the male to female ratio was 1∶1.07. The main reasons were cerebrovascular disease, orthopedic disease, kidney disease, etc. It was used in 84.21% of clinical departments in the hospital. The average course of treatment was (8.00±5.28) d, the daily dose ranged from 150-600 mg/time, and all the drugs were administered intravenously once a day. The solvent mainly used 0.9% Sodium Chloride Injection (92.42%). The number of combined drug varieties was 130. ADR occurred in 7 cases (0.41%),mainly manifested as skin and accessory damage. Irrational drug use was mainly manifested in over-indication drug use, long duration of drug treatment, inappropriate choice of solvent and combined use of drugs with similar efficacy.Conclusion Clinical pharmacists actively monitored Xueshuantong for Injection based on the pharmacovigilance system of sentinel hospitals, and evaluated its rationality in clinical application and the occurrence of adverse reactions. Most of the patients were elderly, and the number of combined drugs was large, and there were repeated drugs. The occurrence of ADR was related to age, combined medication and so on. Clinical pharmacists should strengthen medication monitoring of patients and guide clinicians to use drugs safely and rationally.

Key words： Xueshuantong for Injection Active monitoring Clinical application Rationality analysis Adverse drug reaction

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	SONG Yuanyuan
	LI Heng

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SONG Yuanyuan,LI Heng. Active monitoring analysis of Xueshuantong for Injection was carried out based on hospital pharmacovigilance system[J]. 中国当代医药, 2022, 29(27): 130-133.

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https://www.dangdaiyiyao.com/EN/ OR https://www.dangdaiyiyao.com/EN/Y2022/V29/I27/130

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