益生菌辅助盐酸米诺环素治疗中度慢性牙周炎的效果

Abstract
Figure/Table
References (21)
Related Citation (15)

Download: PDF (466 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To explore the effect of Probiotic assisted Minocycline Hydrochloride on moderate chronic periodontitis. Methods A total of 90 patients with moderate chronic periodontitis admitted to Maternal and Child Health Care Hospital of Ganzhou City from April 2021 to March 2022 were selected as the research objects and divided into control group and observation group according to the random number table method, with 45 cases in each group. The control group were treated with Minocycline Hydrochloride, the observation group were treated with Probiotic assisted Minocycline Hydrochloride. The clinical treatment effect, oral health (scores of oral health assessment tool [OHAT],clinical attachment loss [CAL], gingival index [GI], probing depth [PD], plaque index [PLI], sulcus bleeding index[SBI])and local inflammatory reaction indexes (gingival crevicular fluid tumor necrosis factor-α [TNF-α], interleukin-6 [IL-6]and interleukin-8 [IL-8]) before and after treatment were compared between the two groups. Results The total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant(P<0.05). There was no significant difference in OHAT score between the two groups before treatment (P>0.05). The OHAT score of the observation group after treatment was lower than that of the control group, and the difference was statistically significant (P<0.05). Before treatment, there was no significant difference in CAL, GI, PD, PLI and SBI between the two groups (P>0.05). After treatment, CAL, GI, PD, PLI and SBI in the observation group were lower than those in the control group, and the differences were statistically significant (P<0.05). Before treatment, there was no significant difference in gingival crevicular fluid inflammation index between the two groups (P>0.05). After treatment,the levels of TNF-α, IL-6 and IL-8 in the observation group were lower than those in the control group, and the differences were statistically significant (P<0.05). Conclusion The application effect of Probiotic assisted Minocycline Hydrochloride in patients with chronic periodontitis is better, and it can significantly improve the oral health and local inflammatory reaction, so its application value in the patients with chronic periodontitis is higher.

Key words： Probiotic Minocycline hydrochloride Chronic periodontitis Clinical effect Oral health Local inflammatory reaction

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors

Cite this article:

URL:

https://www.dangdaiyiyao.com/EN/ OR https://www.dangdaiyiyao.com/EN/Y2022/V29/I27/118

[1]	李永强，张英，周芳，等.益生菌含片联合基础牙周治疗对慢性牙周炎伴口臭患者口腔微生态的影响探讨[J].实用临床医药杂志，2019，23（1）：63-66，70.
[2]	吕敏敏，于兰，郭洁，等.益生菌制剂辅助治疗慢性牙周炎疗效和美学效果观察[J].中国美容医学，2020，29（7）：138-141.
[3]	张瑜，谢倩倩，汤凯淇，等.米诺环素辅助治疗对老年慢性牙周炎患者血清、龈沟液骨代谢及相关炎症因子的影响[J].中国老年学杂志，2020，40（10）：2131-2134.
[4]	肖玥，叶丽君，殷小佳，等.益生菌联合牙周基础治疗对慢性牙周炎的疗效分析[J].实用口腔医学杂志，2020，36（6）：949-953.
[5]	吴亚菲.牙周病学[M].2 版.北京：人民卫生出版社，2019：30-36.
[6]	罗业姣，龚仁国，陈琦，等.盐酸米诺环素软膏联合布洛芬对慢性牙周炎患者龈沟液TNF-α、IL-1β、IL-8 水平及生活质量的影响[J].现代生物医学进展，2019，19（20）：3935-3938，3967.
[7]	吕敏敏，于兰，郭洁，等.益生菌片含服对不同程度慢性牙周炎患者牙周PLI、BI、PD、AL 水平及美学修复的影响[J].中国美容医学，2020，29（11）：127-131.
[8]	李雁，吴海燕，王玉娥，等.益生菌含片联合基础牙周治疗对慢性牙周炎伴口臭患者口腔微生态的影响[J].中国当代医药，2020，27（8）：121-123.
[9]	王丽，陈贤，于钦，等.西帕依固龈液联合米诺环素治疗牙周炎的临床效果观察[J].解放军医药杂志，2020，32（6）：69-72.
[10]	Vives-Soler A，Chimenos-Küstner E.Effect of probiotics as a complement to non -surgical periodontal therapy in chronic periodontitis: a systematic review[J].Med Oral Patol Oral Cir Bucal，2020，25（2）：161-167.
[11]	Bustamante M，Oomah BD，Mosi-Roa Y，et al.Probiotics as an Adjunct Therapy for the Treatment of Halitosis，Dental Caries and Periodontitis[J].Probiotics Antimicrob Proteins，2020，12（2）：325-334.
[12]	刘永召，郑瑞，韩淑伶.盐酸米诺环素对牙周炎大鼠的治疗效果及对大鼠IL-8、hs-CRP、TNF-α 的影响[J].川北医学院学报，2019，34（3）：349-353.
[13]	张智强，张煜，李洪利.替硝唑、甲硝唑联合盐酸米诺环素对牙周炎患者牙周临床指标和炎症反应的影响[J].现代医学与健康研究（电子版），2021，5（17）：89-91.
[14]	蒋天娇，王鑫，马楠.培氟沙星联合盐酸米诺环素治疗牙周炎疗效及对早期牙周指标和龈沟液中骨钙素水平的影响[J].河北医学，2020，26（2）：230-234.
[15]	孙娟.盐酸米诺环素辅助牙周炎基础治疗对牙周炎患者临床疗效的影响观察[J].中华养生保健，2021，39（12）：174-176.
[16]	Morales A，Contador R，Bravo J，et al.Clinical effects of probiotic or azithromycin as an adjunct to scaling and root planning in the treatment of stage Ⅲperiodontitis：a pilot randomized controlled clinical trial[J].BMC Oral Health，2021，21（1）：12.
[17]	Vohra F，Bukhari IA，Sheikh SA，et al.Effectiveness of scaling and root planing with and without adjunct probiotic therapy in the treatment of chronic periodontitis among shamma users and non-users: A randomized controlled trial[J].J Periodontol，2020，91（9）：1177-1185.
[18]	闫志刚.盐酸米诺环素软膏联合替硝唑对慢性牙周炎患者氧化应激反应及龈沟液炎症因子水平的影响[J].中国医药导报，2021，18（30）：121-123.
[19]	刘钦赞，庞真贞，李晔.盐酸米诺环素软膏联合替硝唑治疗对慢性牙周炎患者龈沟液中IL-10、TGF-β 及外周血Th17、Treg 水平的影响[J].临床和实验医学杂志，2019，18（9）：966-969.
[20]	徐剑波，王丹丹，彭旭霖.益生菌联合牙周基础治疗对牙周炎合并2 型糖尿病患者龈沟液中炎症因子和骨代谢因子的影响[J].中华临床医师杂志（电子版），2021，15（7）：515-519.
[21]	李建珍，蒋林香，张美龄.益生菌联合牙周基础治疗对慢性牙周炎患者口腔致病菌的影响[J].中国微生态学杂志，2021，33（3）：297-300.