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2022 Vol. 29, No. 16 Published: 2022-06-08

	5	Application effect of Dapagliflozin in type 2 diabetic kidney disease
		XU Xiaohong；ZHANG Ce；MI Xia；ZHANG Chi；ZHOU Feihong；WANG Junsheng； ZHU Ai′min
		Objective To explore the application effect of Dapagliflozin in type 2 diabetic kidney disease. Methods A total of 40 patients with type 2 diabetic kidney disease admitted to the Department of Nephrology, Suqian Hospital,Nanjing Gulou Hospital Group from July 2020 to July 2021 were selected as the research subjects. They were divided into control group (n=20) and observation group (n=20) by random number table method. The control group was treated with hypoglycemic drugs besides Dapagliflozin, while the observation group was treated with Dapagliflozin 10 mg once a day. Both groups were given diet control and exercise intervention. The body mass index (BMI), systolic blood pressure(SBP), diastolic blood pressure (DBP), serum fasting glucose (FPG), glycosylated hemoglobin (HbA1c), total cholesterol(TC), triglyceride (TG), high density lipoprotein (HDL), low density lipoprotein (LDL), serum creatinine (SCr), cystatin C(CysC), serum uric acid (SUA), type B brain natriuretic peptide (BNP), estimated glomerular filtration rate (eGFR), urinary protein/creatinine ratio (UACR), 24-hour urinary albumin quantification (24 h UAlb), left ventricular ejection fraction (LVEF) were compared between the two groups before treatment and 12 weeks after treatment. The incidence of adverse reactions was compared between the two groups. Results After 12 weeks of treatment, FPG, HbA1c, UACR,24 h UAlb, SUA and BNP in the observation group were lower than those before treatment, while LVEF in the observation group after 12 weeks of treatment was higher than that before treatment, the differences were statistically significant (P＜0.05). After 12 weeks of treatment, HbA1c, UACR, 24 h UAlb, SUA and BNP in the observation group were lower than those in the control group, while LVEF in the observation group was higher than that in the control group,the differences were statistically significant (P＜0.05). After 12 weeks of treatment, there were no significant differences in SBP, DBP, body weight, BMI, FPG, TC, TG,HDL, LDL, SCr, eGFR and CysC between the two groups(P＞0.05). The incidence of hypoglycemia in observation group was lower than that in control group, and the difference was statistically significant (P＜0.01). There was no significant difference in the incidence of urinary tract infection between the two groups (P＞0.05). The total incidence of adverse reactions in observation group was lower than control group, and the difference was statistically significant (P＜0.05). Conclusion Dapagliflozin can decrease UACR, 24 h UAlb, HbA1c, BNP, SUA and increase LVEF in patients with type 2 diabetic kidney disease, and has protective effect on heart and kidney function in patients with type 2 diabetic kidney disease.
		2022 Vol. 29 (16): 5-10 [Abstract] ( 30 ) HTML (1 KB) PDF (0 KB) ( 14 )

	11	Research on mechanism of baicalin inhibiting cardiac fibroblast differentiation in diabetes rats
		XU Qiuling；GUO Ran；WANG Yining；SUN Wei；ZHANG Xudong；ZHENG Xuezhi
		Objective The purpose of the experiment was to study mechanism of baicalin inhibiting cardiac fibroblast differentiation in diabetes rats. Methods A total of 24 male SD rats from April to June 2021 were selected as the research objects. They were divided into control group (8 cases), model group (8 cases) and treatment group (8 cases) by randomized block design. The control group was fed with common feed, the model group was injected with 45 mg/kg streptozotocin by tail vein to establish diabetes model and fed with common feed. The treatment group was injected with 45 mg/kg streptozotocin by tail vein and the baicalin solution was intraperitoneally injected at a dose of 15 μmol/L per kilogram per day after the diabetes model succeeded, fed with common feed. Blood glucose, cardiac mass index, microRNA-146a (miR-146a) and α-smooth muscle cell actin (α-SMA) were compared among three groups. Results The blood glucose and heart weight index in the treatment group were lower than that in the model group, and the differences were statistically significant (P＜0.05). The blood glucose and heart weight index in the treaatment group were higher than those in the control group, and the differences were statistically significant (P＜0.05). MiR-146a in the treatment group was higher than that in the model group, α-SMA in the treatment group was lower than that in the model group, and the differences were statistically significant (P＜0.05). MiR-146a in the treatment group was lower than that in the control group, α-SMA in the treatment group was higher than that in the control group, and the differences were statistically significcant (P＜0.05). Conclusion Baicalin inhibited cardiac fibroblast differentiation and intervened myocardial fibrosis in diabetes rats, the mechanism was related to the baicalin regulated expression of miR-146a and inhibited α-SMA protein.
		2022 Vol. 29 (16): 11-14 [Abstract] ( 27 ) HTML (1 KB) PDF (0 KB) ( 15 )

	15	Analysis on efficacy and safety of supermicro percutaneous channel nephrolithotripsy and micro percutaneous channel nephrolithotripsy in patients with kidney stones with diameter ＞2 cm
		TAN Rizhao
		Objective To investigate the efficacy and safety of supermicro percutaneous channel nephrolithotripsy and micro percutaneous channel nephrolithotripsy in the treatment of patients with kidney stones with diameter ＞2 cm.Methods A total of 40 patients with kidney stones with diameter ＞2 cm who were admitted to Foshan Fuxing Chancheng Hospital from January 2016 to December 2020 were selected as the research subjects. They were divided into the observation group and the control group by the random number table method, with 20 patients in each group.The observation group was treated with supermicro percutaneous channel nephrolithotripsy, while the control group was treated with micro percutaneous channel nephrolithotripsy. The stone clearance rate (SFR) of 3 d after surgery was compared between the two groups. The intraoperative channel establishment time, lithotripsy time, whole surgery time and hospital stay were compared between the two groups. The levels of hemoglobin (Hb), serum creatinine (SCr), Creactive protein (CRP) and procalcitonin (PCT) in the two groups before and after surgery were compared. The incidence of postoperative complications (bleeding and fever) was compared between the two groups. Results There was no significant difference in SFR between the two groups (P＞0.05). The intraoperative channel establishment time in observation group was shorter than that in control group, the lithotripsy time and whole surgery time were longer than those in control group, with statistically significant differences (P＜0.05). There was no significant difference in the length of hospital stay between the two groups (P＞0.05). Before surgery, there were no significant differences in the levels of SCr, CRP, PCT and Hb between the two groups(P＞0.05).After surgery,there were no significant differences in the levels of SCr, CRP and PCT between the two groups (P＞0.05). The Hb level in observation group was higher than that in control group, the difference was statistically significant (P＜0.05). The SCr, CRP, PCT levels in the two groups after operation were higher than those before surgery, and Hb levels in the two groups after operation were lower than those before surgery, the differences were statistically significant (P＜0.05). There was no significant difference in the total incidence of postoperative complications between the two groups (P＞0.05). Conclusion Supermicro percutaneous channel nephrolithotripsy and micro percutaneous channel nephrolithotripsy are both efficient and safe lithotriptic methods, and no significant differences are observed in the incidences of postoperative SFR and complications between the two. However, supermicro percutaneous channel nephrolithotripsy is recommended for clinical application due to its relatively short time of establishing channels and less damage to tissues.
		2022 Vol. 29 (16): 15-19转24 [Abstract] ( 23 ) HTML (1 KB) PDF (0 KB) ( 13 )

	20	Efficacy and safety of low-dose Sacubitril Valsartan in treatment of heart failure with reduced ejection fraction in the elderly
		LIU Yuansheng；ZHOU Hua ；LIU Zhongwen； LIAO Bin； LIU Lingjuan； OU Junping▲
		Objective To evaluate the therapeutic effect and safety of low-dose Sacubitril Valsartan in treatment of heart failure with reduced ejection fraction (HFrEF) in the elderly patients. Methods A total of 82 elderly patients with HFrEF (age≥60 years old) treated in Department of Cardiology of Shanghai East Hospital Ji′an Hospital from April 2019 to March 2021 were selected as research objects. They were divided into study group (n=42) and control group(n=40) according to coin toss method. The control group was treated with routine anti chronic heart failare method, the study group treated with Sacubitril Valsarta after stopping using angiotensin converting enzyme inhibitor (ACEI) in routine treatment. The 6 minutes walking test (6-MWT), plasma N-terminal pro-B-type natriuretic peptide (NTproBNP) and cardiac ultrasound were determined before and after 6 months of treatment to detect the patients′ cardiac function. The changes of cardiac function grade indexes in the two groups were evaluated, and the treatment effect and drug safety of the two groups were analyzed. Results There were no statistically significances in plasma NT-proBNP,left ventricle ejection fraction (LVEF), left ventricular end diastolic diameter (LVEDD), left atrial diameter (LA),systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR), 6-MWT levels between two groups before treatment (P＞0.05). After 6 months of treatment, plasma NT-proBNP, LVEDD, LA, SBP, DBP, HR in study group were lower than those in control group, while the levels of LVEF and 6-MWT in study group were higher than those in control group, the differences were statistically significant (P＜0.05). The total effective rate of the study group was higher than that of the control group, the difference was statistically significant (P＜0.05). While there was no significant difference in total incidence of adverse reactions between the two groups (P＞0.05). Conclusion Low-dose Sacubitril Valsartan can effectively inhibit the ventricular remodeling of elderly HFrEF patients, as well improve clinical symptoms and exercise endurance in elderly HFrEF patients with good safety.
		2022 Vol. 29 (16): 20-24 [Abstract] ( 25 ) HTML (1 KB) PDF (0 KB) ( 11 )

	25	Effect of insulin pump combined with flash glucose monitoring system in diabetic patients
		LI Lijie；XING Yanhong ；CHU Xiaofang
		Objective To investigate the effect of insulin pump combined with flash glucose monitoring system (FGM)in diabetic patients. Methods A retrospective analysis was performed on the clinical data of 117 diabetic patients admitted to the Dalian Central Hospital, Dalian Medical University from October 2019 to June 2021, and they were divided into observation group (n=58) and control group (n=59) according to the intervention methods. The control group was treated with insulin pump, and the observation group was treated with FGM. Fasting blood glucose (FPG) and 2 h postprandial blood glucose (2 h PG) were compared between the two groups at admission, before discharge and 3 months after discharge. Glycosylated hemoglobin (HbA1c), triglycerides (TG), total cholesterol (TC), low-density lipoprotein(LDL) and high-density lipoprotein (HDL) were compared between the two groups at admission and 3 months after discharge. The incidence of hypoglycemic events, times of blood glucose measurement, time of blood glucose standard and length of hospital stay were compared between the two groups. Results There were no significant differences in FPG and 2 h PG between the two groups at admission (P＞0.05). FPG and 2 h PG before and 3 months after discharge in both groups were lower than those at admission, and FPG and 2 h PG in observation group were lower than those in control group 3 months after discharge, the differences were statistically significant (P＜0.05). There were no significant differences in HbA1c and blood lipid indexes between the two groups on admission (P＞0.05). 3 months after discharge,HbA1c, TG, TC and LDL in both groups were lower than those in admission, and HbA1c, TG and LDL in observation group were lower than those in control group, the differences were statistically significant (P＜0.05). There were no significant differences in TC and HDL between the two groups 3 months after discharge (P＞0.05). There was no significant difference in the incidence of hypoglycemic events between the two groups (P＞0.05). The time of blood glucose reaching standard in the observation group was longer than that in the control group, and the times of daily blood glucose measurement was less than that of control group, and hospital stay was shorter than that in the control group, with statistical significance (P＜0.05). Conclusions Compared with patients wearing insulin pump alone, patients with insulin pump combined with FGM had shorter average length of hospital stay, less pain, improved biochemical indicators after discharge, improved patient compliance, return visit rate and attention, and more helpful for disease control.
		2022 Vol. 29 (16): 25-29 [Abstract] ( 20 ) HTML (1 KB) PDF (0 KB) ( 11 )

	30	Effect of PDK1 in regulating cardiac outflow tract development and the synergetic effect with Nkx2.5 on artrioventricular canal formation in mice
		LUO Hongmei；YANG Zhongzhou； SHAN Congjia
		Objective To observe the effect of phosphoinositide-dependent protein kinase-1 (PDK1) in regulating development of cardiac outflow tract (OFT) and the synergetic effect with Nkx2.5 on artrioventricular canal (AVC) formation in mice. Methods Crossed PDK1F/F mouse with Nkx2.5-cre mouse, in the second progeny got the mice with PDK1F/+,PDK1+/+ and PDK1F/F three kinds of genotypes, in each type Nkx2.5-cre was positive or negative. After the genotype of mouse was confirmed by PCR, the phenotype of heart was analyzed, firstly the general appearance was observed under microscope and photos were taken, then the hearts were made into paraffin sections, the microstructure of hearts was observed under microscope after being dyed with HE. Results All the mice could survive to birth. The control mice PDK1F/F showed normal heart structure, however, PDK1F/F, Nkx2.5-cre mice all displayed prominent pulmonary stenosis,the phenotype included narrow vessel, non-division of pulmonary valve and aneurysm. And in one PDK1+/+ case, the heart developed into three cavities, two atriums and one ventricle without AVC being developed to separate the cavities.And in another PDK1F/+，Nkx2.5-cre case，the heart was developed into four cavities, two atriums and two ventricles, equally lacking AVC developed to divide the cavities, meanwhile, the OFT failed to separate. Considering Nkx2.5-cre mouse is a cre knock-in mouse, in which one Nkx2.5 allele is damaged, it is possible to cause heart malformation even though PDK1 isn′t knocked out completely. Conclusion PDK1 is an important factor which controls OFT development,and it probably cooperates with Nkx2.5 to regulate cardiac OFT, AVC development.
		2022 Vol. 29 (16): 30-34 [Abstract] ( 26 ) HTML (1 KB) PDF (0 KB) ( 13 )

	35	Value of combined detection of vascular endothelial growth factor, carbohydrate antigen 125 and human epididymis protein 4 in the diagnosis of ovarian carcinoma
		LIU Xuebo
		Objective To investigate the clinical value of combined detection of vascular endothelial growth factor(VEGF), carbohydrate antigen 125 (CA125) and human epididymis protein 4 (HE4) in the diagnosis of ovarian cancer.Methods From January 2017 to June 2019, 60 ovarian cancer patients admitted to Taishan District People′s Hospital of Tai′an City were selected as the ovarian cancer group. From January 2017 to June 2019, 60 patients with benign ovarian diseases admitted to Taishan District People′s Hospital of Tai′an City were selected as the benign ovarian diseases group, and 60 healthy women who underwent health check-up from January 2017 to June 2019 at Taishan District People′s Hospital of Tai′an City were selected as the control group. The serum levels of VEGF, CA125 and HE4 were measured, the serum levels of VEGF, CA125 and HE4 were compared among ovarian cancer patients, benign ovarian disease patients and healthy women, the receiver operating characteristic (ROC) curve was used to analyze the diagnostic value of three separate and combined tests for ovarian cancer. Results The levels of VEGF, CA125 and HE4 in ovarian cancer group were higher than those in control group and benign ovarian disease group, and the differences were statistically significant (P＜0.001). The level of VEGF in benign ovarian disease group was higher than that in normal control group, the difference was statistically significant (P＜0.001). There were no statistically significant differences in the CA125 and HE4 levels between benign ovarian disease group and control group (P＞0.05). The serum levels of CA125,VEGF and HE4 in patients with stage Ⅳovarian cancer were higher than those in patients with stage Ⅰ-Ⅱand Ⅲovarian cancer, and the differences were statistically significant (P＜0.05). Serum levels of CA125, VEGF and HE4 in patients with stage Ⅲovarian cancer were higher than those in patients with stage Ⅰ-Ⅱovarian cancer, and the differences were statistically significant (P＜0.05). The sensitivity of VEGF, CA125 and HE4 to ovarian cancer were 85.00%,73.33%, 65.00% respectively. The specificity of VEGF, CA125 and HE4 to ovarian cancer were 79.17%, 68.33% and 89.17% respectively. In VEGF, CA125 and HE4 single test, the diagnostic efficacy of VEGF in ovarian cancer was the highest. The sensitivity and specificity of three combined tests among VEGF, CA125 and HE4 were 71.67% and 91.67% respectively. The test′s sensitivity and specificity of CA125 combined with HE4 were 83.33% and 72.50% respectively. The diagnostic efficacy of three combined tests was higher than that of single test and CA125+HE4 test. The sensitivity and specificity of three combined tests among VEGF, CA125 and HE4 were 84.60% and 93.00% respectively, and the sensitivity and specificity of CA125 combined with HE4 were 81.50% and 76.80% respectively. The diagnostic efficacy of three combined tests was higher than that of CA125+HE4. Conclusion The combined determination of CA125 and serum HE4 and VEGF improves the diagnosis of ovarian epithelial cancer, especially for early ovarian cancer diagnosis.
		2022 Vol. 29 (16): 35-38转48 [Abstract] ( 24 ) HTML (1 KB) PDF (0 KB) ( 17 )

	39	Effect of skeletal muscle aging on low back pain
		JIN Jing；CHEN Yimin；LIN Jianping； GUO Mingling； GOU Yanyun；CHEN Shaoqing； WANG Hong
		Low back pain is a common disease, it′s incidence and outcome are closely related to the stability of lumbar spine. The pathogenesis of low back pain is still unclear, and previous studies on the pathogenesis of low back pain mostly focus on the osteoarticular system and nervous system. With the proposal of the concept of skeletal muscle aging and the development of spinal biomechanics and anatomy, scholars began to explore the pathologic mechanism of skeletal muscle aging in the waist and its interaction with pathological changes in the spine. Studies have shown that a series of pathological changes of skeletal muscle caused by aging, such as systemic low-grade inflammation, senile obesity, sarcopenia and physiological and biochemical changes, may be the key factors to induce low back pain. Based on this, through the consult relevant literature and research in recent years, the author trying to discuss the incident of low back pain from the angle of skeletal muscle ageing, and summarize the correlation between skeletal muscle aging in the waist and the low back pain, so as to provide effective reference for the future medical biology research.
		2022 Vol. 29 (16): 39-43 [Abstract] ( 23 ) HTML (1 KB) PDF (0 KB) ( 11 )

	44	Progress in studying D-dimer and platelet to lymphocyte count to the incidence of Henoch-Schonlein purpura nephritis in children
		LU Yi；LI Yufen； LU Xiaoni；WANG Jing；LU Dandan
		Henoch-Schonlein purpura is a kind of immune hemorrhagic vasculitis with unknown etiology. It often affects the skin, gastrointestinal tract, limb joints and kidney, and the incidence of renal involvement is 20% to 60%. It is called Henoch-Schonlein purpura nephritis and the most serious complication of Henoch-Schonlein purpura. It is the most important factor affecting the long-term prognosis and quality of life of children with Henoch-Schonlein purpura. It is often manifested as abnormal results of urine laboratory examination and kidney biopsy, and in severe cases,renal function is often impaired. Therefore, it is important to explore effective and simple laboratory examination indexes to predict the occurrence of Henoch-Schonlein purpura nephritis and to explore the effect of these indexes for the severity of kidney damage and prognosis of the disease. When the body has inflammation, D-dimer level will increase and its function will be enhanced, which is closely related to inflammation and hemorrhagic diseases. Platelet to lymphocyte count ratio is an important indicator of inflammatory response, but its relationship with Henoch-Schonlein purpura nephritis is not clear at present. This article reviews the clinical significance of D-dimer and platelet to lymphocyte count ratio in patients with Henoch-Schonlein purpura nephritis.
		2022 Vol. 29 (16): 44-48 [Abstract] ( 24 ) HTML (1 KB) PDF (0 KB) ( 12 )

	49	Advances in macrophage functions and its role in heart disease
		DONG Jingwei；MIAO Liu
		Macrophages are multifunctional immune cells with heterogeneity and plasticity. They are important mediators of inflammation and tissue remodeling and play a vital role in the process of organ development and maintenance of tissue homeostasis. Macrophages are the most abundant immune cells in myocardium which are divided into classical(M1) and alternative (M2) polarization phenotypes according to their functions. This classification method is to co-culture macrophages with specific cytokines in vitro to define the functions, which is considered too simple. At present,macrophages are divided into CC chemokine receptor 2 (CCR2) and CCR2- subgroups according to their origin and its surface receptors CCR2+. Macrophages become a hotspot of research for they performing various functions in response to the changing tissue environment during myocardial inflammation and injury. Cardiovascular disease is one of the most common diseases in the world. Accumulating evidence suggests that myocardial macrophages play a critical and complex role in acute inflammation and regeneration following myocardial injury. Based on the latest research, this paper detail the diversity of properties and functions of macrophages and their current research status in cardiac disease.
		2022 Vol. 29 (16): 49-52 [Abstract] ( 23 ) HTML (1 KB) PDF (0 KB) ( 11 )

	53	Research progress on characteristics of depression and folic acid intervention in different populations
		XUE Juan； MA Wenbin；TU Hua；GU Rui；LIU Kang； CHENG Yongzhi；LIAN Zenglin
		Depression is a common mental disease that′s closely related to modern life, and its incidence is increasing year by year, and the existing mental health resources have some deficiencies so that the identification rate of depression is low, the disease duration is long, and the recurrence rate is high. Children and adolescents, pregnant women,older adults are at risk for depression, the onset and presentation of depression vary among different populations, and there are risks associated with antidepressant drug interventions during clinical diagnosis and treatment. The latest research shows that the deficiency of folic acid, a water-soluble vitamin, that is essential for human life activities, not only leads to abnormal neural tube development in the fetus during the embryonic period, but may also be associated with neuropsychiatric disorders such as depression. While supplementation of folic acid (especially active folate) for improving depression status and regulating neurotransmitters has a certain adjuvant therapeutic effect. In response to this finding, this paper provides a review of depression characteristics and folic acid interventions in different populations, the aim of this paper reveals the possible role of folic acid in depression in different populations and provides a new way of thinking for the treatment of depression.
		2022 Vol. 29 (16): 53-56 [Abstract] ( 31 ) HTML (1 KB) PDF (0 KB) ( 12 )

	57	Study on therapeutic effect of Buxu Yangle Syrup on bromocriptine mesylate induced hypogalactia in rats
		LI Na； LI Qingping；CHEN Xiaoyi； HUANG Xiaotong； FANG Gang
		Objective To investigate the therapeutic effect of Buxu Yangle Syrup (BXYL) on Bromocriptine mesylate induced lactation deficiency in rats. Methods Bromocriptine mesylate was used to establish a rat model of lactation deficiency. The body weight and lactation of the offspring were recorded. The serum prolactin was detected by enzyme linked immunosorbent assay (ELISA). The histopathological changes of hypophysis and mammary gland were observed.Results The body weight and growth rate of the BXYL high and medium dose groups were higher than those of the model group, and the differences were statistically significant (P＜0.05). The 8 h lactation per day of the BXYL high,medium and low dose groups on the 3-10 d after delivery were higher than those of the model group, and the differences were statistically significant (P＜0.01). The serum quercetin levels in the BXYL high and medium dose groups on the 3rd, 7th, and 11th days after delivery were higher than those in the model group, and the differences were statistically significant (P＜0.05). Compared with the model group, the number of mammary acini and ducts in each dose group of BXYL increased significantly, expanded and proliferated, and the adipose connective tissue between mammary lobules decreased. Compared with the model group, the morphology of pituitary cells in each dose group of BXYL was normal, and eosinophils increased. Conclusion Buxu Yangle Syrup has obvious effect on promoting lactation in rats with lactation deficiency.
		2022 Vol. 29 (16): 57-60转64 [Abstract] ( 25 ) HTML (1 KB) PDF (0 KB) ( 12 )

	61	Production technology and internal quality control evaluation method of Shengxue Yangchao Ointment
		YE Xiaoling；LUO Yu；LAI Jijian
		Objective To explore the effect of internal quality control evaluation methods on improving the production process, the rationality, stability and effectiveness of traditional Chinese medicine ointment of Shengxue Yangchao Ointment. Methods A total of 34 samples were randomly selected from the finished products of Shengxue Yangchao Ointment prepared from March to October 2021 as the experimental group, and 34 samples were randomly selected from the finished products of Shengxue Yangchao Ointment prepared from March to October 2020 as the reference group in Shaoguan Hospital of Traditional Chinese Medicine. The experimental group was prepared by internal quality control evaluation method, and the reference group was prepared by traditional paste recipe. The fluidity, appearance,hardness and taste of the two groups were compared. Results The fluidity, appearance and shape, hardness, and taste scores of the experimental group were higher than those of the control group, and the differences were statistically significant (P＜0.05). Conclusion The internal quality control evaluation method can effectively improve the production process of Shengxue Yangchao Ointment, and significantly improve the fluidity, appearance, hardness and taste of Shengxue Yangchao Ointment.
		2022 Vol. 29 (16): 61-64 [Abstract] ( 23 ) HTML (1 KB) PDF (0 KB) ( 14 )

	65	Application effect of whole-course analgesia with Esketamine on patients with amputation of diabetic foot
		MAO Haifei；MEI Kaibo；WANG Qiming；LIU Fanglan
		Objective To observe the application effects of whole-course analgesia with Esketamine on patients with diabetic foot amputation. Methods Forty patients undergoing diabetic foot amputation in Shangrao People′s Hospital from June 2020 to September 2021 were selected as the research subjects, and were divided into experimental group (n=20)and blank group (n=20) according to random number table method. The trial group was given 0.1 μg/kg of Esketamine for analgesia before anesthesia, and then given Midazolam, Esketamine, Propofol, and Rocuronium Bromide for anesthesia induction, while the blank group was not given analgesia treatment before anesthesia and adopted Midazolam, Fentanyl, Propofol and Rocuronium Bromide for anesthesia induction. After surgery, the experimental group received patient-controlled analgesia pump with Esketamine and Dexmedetomidine, and the blank group received Fentanyl and Dexmedetomidine connected to patient-controlled analgesia pump. Serum C-reactive protein (CRP), cortisol (Cor), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), γinterferon (IFN-γ), CD3+, CD4+and CD8+at 15 min before anesthesia (T0), at 24 h after surgery (T1) and at 48 h after surgery (T2), the number of effective analgesia pump compressions at T1 and T2, visual analogue scale (VAS)score, postoperative adverse reactions, scores of short-form McGill pain questionnaire (SF-MPQ) and Hamilton anxiety scale (HAMA) and incidence rate of phantom limb pain at 6 weeks after surgery and satisfaction at 3 months after surgery were compared between the two groups of patients. Results There were no significant differences in CRP, Cor,IL-6, TNF-α and IFN-γ between two groups at T0 (P＞0.05). At T1 and T2, CRP, Cor, IL-6, TNF-α and IFN-γ in the experimental group were lower than those in the control group, with statistical significance (P＜0.05). There were no significant differences in CD3+, CD4+and CD8+between two groups at T0 (P＞0.05). At T1 and T2, CD8+in the experimental group was lower than that in the blank group, while CD3+ and CD4+ were higher than those in the blank group, with statistical significance (P＜0.05). The VAS score of T1 and T2 in the experimental group was lower than that in the blank group, and the number of effective analgesic pump pressing was less than that in the blank group, with statistical significance (P＜0.05). The incidence of adverse reactions in experimental group was lower than that in blank group, and the difference was statistically significant (P＜0.05). PRI, VAS, PPI and HAMA in the experimental group were lower than those in the blank group, and the incidence of postoperative phantom limb pain in the experimental group was lower than that in the blank group, with statistical significance (P＜0.05). The satisfaction of the experimental group was higher than that of the blank group 3 months after operation, and the difference was statistically significant (P＜0.05). Conclusion The application of Esketamine for whole-course analgesia in patients with diabetic foot amputation can relieve the postoperative stress and immunosuppression, and can significantly reduce the risk of postoperative phantom limb pain through effective analgesia. And the regimen has good safety and is favorable for prognosis and rehabilitation.
		2022 Vol. 29 (16): 65-69 [Abstract] ( 26 ) HTML (1 KB) PDF (0 KB) ( 12 )

	70	Effect of different doses and medication time of roasted Ephedra on clinical efficacy in the treatment of acute exacerbation of chronic obstructive pulmonary disease
		FENG Xujun
		Objective To investigate the effect of different doses and medication time of roasted Ephedra on the clinical efficacy of treating acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods The clinical data of 280 AECOPD patients admitted to Jiujiang First People′s Hospital from January to December 2021 were retrospectively analyzed, and they were divided into control group (70 cases) and observation group (210 cases) according to different treatment methods. The control group was treated with conventional western medicine, and the observation group was treated with conventional western medicine combined with roasted Ephedra. The observation group was divided into group B, group C and group D according to different dosage and duration of medication, with 70 cases in each group.Group B was treated with 12 g roasted Ephedra, 10 d as a course, group C was treated with 6 g roasted Ephedra, 20 d as a course, group D was treated with 12 g roasted Ephedra, 20 d as a course. The clinical efficacy and adverse reactions of the four groups were compared. Results The total effective rate of group B, C and D were higher than that of control group, and the total effective rate of group D was higher than that of group B and C, the differences were statistically significant (P＜0.017). There was no significant difference in total effective rate between group B and group C (P＞0.017). There was no significant difference in the total incidence of adverse reactions among the four groups (P＞0.05).Conclusion Roasted ephedra is safe and effective in the treatment of AECOPD. The difference of roasted ephedra dose and medication time has a great impact on the clinical efficacy and safety of the treatment of AECOPD. The best dose and medication time of roasted Ephedra are 12 g and 20 d as a course of treatment.
		2022 Vol. 29 (16): 70-72转75 [Abstract] ( 26 ) HTML (1 KB) PDF (0 KB) ( 10 )

	73	Clinical effect of Licorzine Granules combined with red and blue light in the treatment of adolescent acne
		WANG Chunhui
		Objective To explore the clinical effect of Licorzine Granules combined with red and blue light in the treatment of adolescent acne. Methods A total of 109 adolescent acne patients treated in Pingshan District People′s Hospital from October 2020 to October 2021 were selected as the research subjects, and were divided into control group (54 cases) and treatment group (55 cases) by random number table method. Control group was treated with Kecuo Yintong Gel, and treatment group was treated with Licorzine Granules combined with red and blue light. The therapeutic effect, the number of different types of skin lesions and the occurrence of adverse reactions were compared between the two groups. Results After 1 month of treatment, the total effective rate of the treatment group was 96.39%, which was higher than that of the control group (83.33%), the difference was statistically significant (P＜0.05). Before treatment, there was no significant difference in the number of different types of skin lesions between the two groups (P＞0.05). After treatment, the number of skin lesions in both groups was less than before treatment, and the number of skin lesions in the treatment group was less than the control group, the differences were statistically significant (P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups (P＞0.05). Conclusion Based on the treatment of Kecuo Yintong Gel, the treatment of adolescent acne patients with Licorzine Granules combined with red and blue light has better effect, and the number of different types of skin lesions is better,which is worth promoting.
		2022 Vol. 29 (16): 73-75 [Abstract] ( 27 ) HTML (1 KB) PDF (0 KB) ( 12 )

	76	Diagnostic value of modified Alvarado score combined with CT multiplane reconstruction in children with acute appendicitis
		PEI Dabing；ZHANG Yizhen； QIU Shengtao；XIONG Chun；WANG Dongya；XIAO Renshun； HE Yongning；ZHANG Xuhua
		Objective To investigate the value of modified Alvarado score combined with CT multiplanar reconstruction(MPR) in the diagnosis of acute appendicitis in children. Methods A total of 116 children with suspected acute appendicitis who were treated in the Department of General Surgery of the Affiliated Hospital of Jinggangshan University from January 2019 to September 2021 were analyzed retrospectively. All children underwent modified Alvarado score and MPR. Postoperative pathological diagnosis results were taken as the gold standard, the sensitivity, specificity, positive predictive value and negative predictive value of different diagnostic methods were statistically analyzed. Results Among 116 children with suspected acute appendicitis, 109 cases were diagnosed as acute appendicitis by postoperative pathology. The sensitivity, specificity, positive predictive value and negative predictive value of the combined diagnosis of the diagnostic methods were higher than Alvarado scoring system and MPR diagnosis，and the differences were statistically significant (P＜0.017). Conclusion Modified Alvarado score combined with MPR had higher sensitivity, specificity, positive predictive value and negative predictive value in the diagnosis of acute appendicitis in children. Therefore,it has the value of popularization and application in clinical work.
		2022 Vol. 29 (16): 76-78转82 [Abstract] ( 26 ) HTML (1 KB) PDF (0 KB) ( 10 )

	79	Effect of Compound Ipratropium Bromide combined with Budesonide atomization inhalation on blood gas indexes in elderly patients with chronic obstructive pulmonary disease
		ZHANG Ying；LIU Yan
		Objective To investigate the effect of Compound Ipratropium Bromide combined with Budesonide atomization inhalation on blood gas indexes in elderly patients with chronic obstructive pulmonary disease (COPD). Methods A total of 80 COPD elderly patients admitted to Xuzhou First People′s Hospital from January 2019 to January 2021 were selected as the study subjects,and were divided into study group (40 cases) and control group (40 cases) by random number table method. The study group received Compound Ipratropium Bromide combined with Budesonide, and the control group received Budesonide, the treatment course was 7 d. The difference in dynamic venous oxygen content (Ca-jvO2),oxygenation index (PaO2/FiO2), 6-minute walking test (6MWT), oxygen saturation (SaO2), BODE index score and the occurrence of adverse reactions were compared between two groups before and after treatment. Results Before treatment,there was no significant difference in SaO2,Ca-jvO2 and PaO2/FiO2 levels between the two groups(P＞0.05).After treatment,the levels of SaO2 and PaO2/FiO2 in the study group were higher than those in the control group, while the levels of CajvO2 were lower than those in the control group,with statistical significances(P＜0.05).There were no significant differences in 6MWT and BODE index between the two groups before treatment (P＞0.05). After treatment, the 6MWT of the study group was higher than that of the control group, and the BODE index was lower than that of the control group, with statistical significances (P＜0.05). No serious adverse reactions occurred in two groups during treatment, and there was no statistical significance in the total incidence of adverse reactions between two groups (P＞0.05). Conclusion Compound Ipratropium Bromide combined with Budesonide atomization inhalation can effectively improve the blood gas indexes and exercise endurance of elderly patients with COPD.
		2022 Vol. 29 (16): 79-82 [Abstract] ( 31 ) HTML (1 KB) PDF (0 KB) ( 8 )

	83	Influence of Probucol combined with secondary prevention of coronary heart disease on oxidative stress indexes and cardiac function in elderly patients with old myocardial infarction
		ZHONG Su；YU Yan
		Objective To investigate the influence of Probucol combined with secondary prevention of coronary heart disease on oxidative stress indexes and cardiac function in elderly patients with old myocardial infarction. Methods A total of 86 elderly patients with old myocardial infarction treated in Chenggong Hospital Affiliated to Xiamen University from October 2019 to January 2021 were selected as the research objects. According to random number table method,they were divided into the observation group (43 cases) and the control group (43 cases). The control group was treated with secondary prevention of coronary heart disease, and the observation group was treated with Probucol on the basis of the control group. The oxidative stress indexes (superoxide dismutase [SOD], malondialdehyde [MDA], glutathione peroxidase [GSH-Px]), echocardiographic indexes (left ventricular ejection fraction [LVEF], cardiac output [CO], cardiac output index [CI] and the mean pulmonary artery pressure), cardiac function grade, adverse reactions during treatment were compared between the two groups. Results The levels of SOD and GSH-Px in the two groups after treatment were higher than those before treatment, and the levels of SOD and GSH-Px in the observation group after treatment were higher than those in the control group, the differences were statistically significant (P＜0.05). The MDA levels of the two groups after treatment were lower than those before treatment, and the MDA level of the observation group after treatment was lower than that of the control group, the differences were statistically significant (P＜0.05). The levels of LVEF, CO and CI in the two groups after treatment were higher than those before treatment, and the levels of LVEF, CO and CI in the observation group after treatment were higher than those in the control group, the differences were statistically significant (P＜0.05). The levels of mean pulmonary artery pressure of the two groups after treatment were lower than those before treatment, and the mean pulmonary artery pressure of the observation group after treatment was lower than that of the control group, the differences were statistically significant (P＜0.05). The cardiac function grading of the two groups after treatment was better than that before treatment, and the cardiac function grading of the observation group after treatment was better than that of the control group, the differences were statistically significant (P＜0.05). There was no significant difference in the total incidence of adverse reactions between the two groups during treatment (P＞0.05). Conclusion Probucol combined with secondary prevention of coronary heart disease can significantly reduce the level of oxidative stress, improve cardiac function and prognosis in elderly patients with old myocardial infarction, and has good safety.
		2022 Vol. 29 (16): 83-86转90 [Abstract] ( 25 ) HTML (1 KB) PDF (0 KB) ( 13 )

	87	Influence of reactive hyperemia index on anthracycline-related cardiotoxicity and its predictive value
		ZHANG Lifu；XIA Ning；ZHANG Li
		Objective To investigate the influence of reactive hyperemia index (RHI) on anthracycline-related cardiotoxicity and its predictive value. Methods The clinical data of 155 breast cancer patients who were treated with anthracycline chemotherapy in Jiangxi Cancer Hospital from April 2020 to September 2020 were retrospectively selected.All patients completed a 1-year follow-up after chemotherapy. According to the occurrence of cardiotoxicity within 1 year，they were divided into the cardiotoxicity group (n=10) and the non-cardiotoxicity group (n=145). After consulting and comparing the clinical data (baseline data and laboratory indicators) of the two groups, the independent risk factors of cardiotoxicity in anthracycline chemotherapy breast cancer patients were found by logistic regression analysis,and the predictive value of RHI on anthracycline-related cardiotoxicity was analyzed. Results The results of univariate analysis showed that RHI was a related factor affecting the cardiotoxicity of breast cancer patients undergoing anthracycline chemotherapy (P＜0.05). The results of multivariate analysis showed that low RHI was an independent risk factor of cardiotoxicity in breast cancer patients undergoing anthracycline chemotherapy (OR＞1, P＜0.05). The receiver operating characteristic curve (ROC) was drawn, and the results showed that the area under the curve (AUC) of RHI predicting the risk of anthracycline-related cardiotoxicity was 0.814, which was more predictive ideal. Conclusion RHI has certain predictive value for the risk of anthracycline-related cardiotoxicity in breast cancer patients.
		2022 Vol. 29 (16): 87-90 [Abstract] ( 30 ) HTML (1 KB) PDF (0 KB) ( 13 )

	91	Application effect of vasodilators combined with sedatives in patients with coronary heart disease with depression
		LI Xingzhou； XU Yulian
		Objective To study the clinical effect of vasodilators combined with sedatives in the treatment of patients with coronary heart disease (CHD) with depression patients. Methods A total of 50 CHD patients with depression treated from June 2020 to September 2021 in Guangzhou Hospital of Integrated Traditional Chinese and Western Medicine were selected for the study. The patients were divided into group A and group B according to random number table method, with 25 cases in each group. Group B was treated with vasodilators alone, and group A was treated with vasodilators combined with sedatives. The clinical effect of the two groups after intervention were compared. The degree of depression of the two groups was evaluated by self-rating depression scale (SDS), and the quality of life of the two groups was evaluated by Seattle angina pectoris quality of life scale (SAQ). At the same time, the changes in indicators of the left ventricular ejection fraction (LVEF), left ventricular end systolic volume index (LVESVI), high-sensitivity Creactive protein (hs-CRP) and tumor necrosis factor-α (TNF-α) were measured. Results There were no significant differences in the indicators of LVEF, LVESVI, hs-CRP and TNF-α between the two groups before treatment (P＞0.05).After treatment, the indicators of LVEF of the two groups were higher than those before treatment, the indicators of LVESVI, hs-CRP and TNF-α of the two groups were lower than those before treatment, the indicators of LVEF in group A after treatment was higher than that in group B, the indicators of LVESVI, hs-CRP and TNF-α in group A after treatment were lower than those in group B, and the differences were statistically significant (P＜0.05). There were no significant differences in the scores of SDS and SAQ between the two groups before treatment (P＞0.05). The SDS scores of the two groups after treatment were lower than those before treatment, and the SAQ scores of the two groups after treatment were higher than those before treatment, the SDS score of group A after treatment was lower than that of group B, and the SAQ score of group A after treatment was higher than that of group B, the differences were statistically significant (P＜0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P＞0.05). Conclusion For CHD patients with depression, the treatment of vasodilators combined with sedatives has a good clinical effect, which can promote the recovery of prognosis, improve the indexes of cardiac function, reduce the indexes of inflammatory factors, reduce the degree of depression, improve the prognosis and improve the quality of life of patients, which is worthy of reference.
		2022 Vol. 29 (16): 91-94转99 [Abstract] ( 24 ) HTML (1 KB) PDF (0 KB) ( 16 )

	95	Influence of valve surgery combined with simultaneous radiofrequency ablation on cardiac rhythm in patients with atrial fibrillation
		MA Xiaolong；PAN Jiahao；ZENG Yuxin； NIE Cong ；HOU Anxing ；ZHOU Qing； CHEN Fei； ZHOU Wenwu▲
		Objective To analyze the clinical effect of valve surgery combined with simultaneous radiofrequency ablation in the treatment of atrial fibrillation and its effect on patients with cardiac rhythm. Methods A total of 60 patients with atrial fibrillation in the First Affiliated Hospital of Hu′nan Normal University from February 2018 to June 2021 were selected as research subjects, and they were divided into the observation group and the control group by random number table method, with 30 patients in each group. The observation group was treated with valve surgery and modified labyrinth bipolar radiofrequency ablation at the same time, while the control group was treated with valve replacement and left atrial appendage ligation. The cardiopulmonary bypass time, mitral valve replacement (MVR) time, double valve replacement (DVR) time, ventilator use time, hospital stay, quality of life, the incidence of complications and changes of cardiac rhythm after treatment were compared between the two groups. Results There were no significant differences in the ventilator use time and hospital stay between the two groups (P＞0.05). The MVR and DVR of the observation group were longer than those of the control group, and the differences were statistically significant (P＜0.05).There were no significant differences in the quality of life scores of physiological function, health self-assessment,physical pain, life vitality, physiological function, social function, emotional role, mental health score and total score between the two groups before treatment (P＞0.05). The scores of physiological function, health self-assessment, life vitality, physiological function, social function, emotional role, mental health and total scores in the quality of life scores in the observation group after treatment were higher than those in the control group, and the differences were statistically significant (P＜0.05). The scores of physiological function, health self-assessment, life vitality, physiological function, social function, emotional role, mental health and total score in the quality of life scores of the observation group after treatment were higher than those before treatment, and the differences were statistically significant (P＜0.05). Except for physical pain, the scores of other dimensions and total scores in the control group after treatment were higher than those before treatment, and the differences were statistically significant (P＜0.05). There were 27 cases of sinus rhythm, 2 cases of atrial fibrillation and 1 case of atrial flutter in the observation group. In the control group, there were 13 cases of sinus rhythm, 15 cases of atrial fibrillation and 2 cases of atrial flutter. There was significant difference in the changes of postoperative cardiac rhythm between the two groups (χ2=15.175, P=0.001). Conclusion Radiofrequency ablation is one of the important surgical methods in the treatment of atrial fibrillation. Valve surgery combined with simultaneous modified radiofrequency ablation is safe and effective, which is conducive to further improve the surgical effect. It can effectively alleviate the symptoms of atrial fibrillation after operation, and the incidence of complications is relatively low and mild. It can be used as the first choice for valve disease complicated with atrial fibrillation.
		2022 Vol. 29 (16): 95-99 [Abstract] ( 26 ) HTML (1 KB) PDF (0 KB) ( 11 )

	100	Effects of Recombinant Human Brain Natriuretic Peptide on brain natriuretic peptide level and cardiac function in patients with acute myocardial infarction after percutaneous coronary intervention
		XING Dong；LIAO Peichao；MA Zhiqiang
		Objective To investigate the effect of Recombinant Human Brain Natriuretic Peptide in patients with acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI). Methods A total of 84 AMI patients admitted to Tengzhou Hospital of Traditional Chinese Medicine from July 2018 to December 2020 were selected and divided into control group and observation group by random number table method, with 42 cases in each group. The control group was given conventional drug therapy after PCI, and the observation group was treated with Recombinant Human Brain Natriuretic Peptide, both groups were followed up for 6 months after treatment. Clinical efficacy, cardiac function,brain natriuretic peptide (BNP) level and incidence of adverse events were compared between the two groups. Results The total effective rate of clinical treatment and left ventricular ejection fraction (LVEF) in the observation group were higher than those in the control group, BNP level, total incidence of adverse events were lower than those in the control group, left ventricular diastolic diameter (LVEDD) and left ventricular posterior wall thickness (LVPWT) were less than those in the control group, the differences were statistically significant (P＜0.05). Conclusion The application of Recombinant Human Brain Natriuretic Peptide in AMI patients after PCI can improve the cardiac function, reduce the level of BNP and the incidence of adverse events, which is conducive to the prognosis of patients.
		2022 Vol. 29 (16): 100-102 [Abstract] ( 26 ) HTML (1 KB) PDF (0 KB) ( 10 )

	103	Application effect of Sacubitril Valsartan and cardiac rehabilitation therapy in patients with heart failure
		SU Heng；ZHU Jun； WANG Guangyan
		Objective To explore the application effect of Sacubitril Valsartan combined with cardiac rehabilitation therapy in patients with heart failure (HF). Methods A total of 71 patients with HF treated in the Affiliated Hospital of Jiangnan University from April 2018 to April 2021 were selected as research objects, they were divided into observation group(36 cases)and control group(35 cases)according to random number table method.The patients in control group were treated with Sacubitril Valsartan, and the patients in observation group were given cardiac rehabilitation therapy on the basis of medication in the control group. The N-terminal pro-B-type natriuretic peptide (NT-proBNP), interleukin-6(IL-6), heart function indexes and functional fitness indexes were compared between the two groups before and after intervention. Results After intervention, the left ventricular fractional shortening (LVFS) and left ventricular ejection fraction (LVEF) in the observation group were higher than those in the control group, and the 6 minutes walking distance (6MWT) in the observation group was longer than that in the control group, the levels of NT-proBNP and IL-6 in the observation group were lower than those in the control group, the differences were statistical significant (P＜0.05).After intervention, the muscle strength and flexibility of the upper and lower limbs, the aerobic endurance and flexibility/balance in the observation group were better than those in the control group, and the differences were statistically significant (P＜0.05). Conclusion Sacubitril Valsartan combined with cardiac rehabilitation therapy can further improve the cardiac function indexes, reduce the level of NT-proBNP and IL-6, and improve the functional physical fitness indexes in patients with HF.
		2022 Vol. 29 (16): 103-106转110 [Abstract] ( 24 ) HTML (1 KB) PDF (0 KB) ( 14 )

	107	Effect of percutaneous coronary intervention through distal radial artery and conventional radial artery in the treatment of elderly patients with coronary heart disease
		ZHOU Haitao； XU Guoxin ；ZHANG Dexin
		Objective To explore the effect of percutaneous coronary intervention (PCI) through distal radial artery and conventional radial artery in the treatment of elderly patients with coronary heart disease. Methods A total of 78 elderly patients with coronary heart disease treated in Yangzhong People′s Hospital of Jiangsu Province from February 2019 to February 2021 were selected as the research objects. They were divided into the control group (39 cases) and the study group (39 cases) according to random number table method. The control group was treated with conventional radial artery PCI, and the study group was treated with distal radial artery PCI. The treatment effect, cardiac function parameters, left ventricular end systolic volume (LVESV) and left ventricular ejection fraction (LVEF) before and after treatment, postoperative complications were compared between the two groups. Results The total effective rate of the study group was higher than that of the control group, the difference was statistically significant (P＜0.05). There were no significant differences in the levels of LVESV and LVEF between the two groups before treatment (P＞0.05). The levels of LVESV in the two groups after treatment were lower than those before treatment, and the levels of LVEF in the two groups after treatment were higher than those before treatment, and the level of LVESV in the study group after treatment was lower than that in the control group, the level of LVEF in the study group after treatment was higher than that in the control group, the differences were statistically significant (P＜0.05). The total incidence of postoperative complications in the study group was lower than that in the control group, the difference was statistically significant (P＜0.05).Conclusion Compared with conventional radial artery PCI, PCI through distal radial artery can significantly improve the curative effect of patients with coronary heart disease aged ＞60 years, promote the recovery of cardiac function and reduce the incidence of postoperative complications.
		2022 Vol. 29 (16): 107-110 [Abstract] ( 30 ) HTML (1 KB) PDF (0 KB) ( 10 )

	111	Effect of "Internet +" on self-management behavior of hypertensive patients in primary hospitals
		XU Ping； LI Linqing
		Objective Explore the application effect of "Internet +" on the self-management behavior of hypertensive patients in primary hospitals. Methods A total of 110 hypertensive patients treated in Zouping People′s Hospital from January 2020 to June 2020 were selected as the research subjects, they were divided into the control group (55 cases)and the observation group (55 cases) according to random number table method. The control group received conventional treatment, nursing, and follow-up methods, while the observation group received "Internet +" to manage hypertensive patients on the basis of conventional interventions. The compliance rate of self-management behaviors, the number of irregularities in each dimension of self-management, the compliance rate of blood pressure and satisfaction between the two groups was compared. Results The self-management behavior compliance rate in the observation group was higher than that in the control group, and the difference was statistically significant (P＜0.05). The numbers of irregularities in the six dimensions of self-management in the observation group were less than those in the control group, and the differences were statistically significant (P＜0.05). The blood pressure compliance rate in the observation group was higher than that in the control group, and the difference was statistically significant (P＜0.05). The satisfaction in the observation group was higher than that in the control group, and the difference was statistically significant (P＜0.05). Conclusion "Internet +" can improve the self-management ability of hypertension patients in primary hospitals, it is worthy of clinical application.
		2022 Vol. 29 (16): 111-114 [Abstract] ( 25 ) HTML (1 KB) PDF (0 KB) ( 18 )

	115	Study on the promoting effect of Baduanjin on rehabilitation of schizophrenia
		WU Huiling； WANG Lingling
		Objective To explore the effect of Baduanjin on the rehabilitation of schizophrenia.Methods A total of 124 patients with schizophrenia admitted to the Department of Rehabilitation, Jiangxi Provincial Psychiatric Hospital from June 2019 to June 2021 were selected as the research objects. They were divided into the observation group and the control group by random number table method, with 62 cases in each group. The control group was treated with conventional medication and nursing intervention, while the observation group was trained with Baduanjin on the basis of the control group. The scores of positive and negative symptom scale (PANSS), brief psychiatric rating scale (BPRS) and Pittsburgh sleep quality index (PSQI) scale were compared between the two groups. Results After 4, 6 and 8 weeks of intervention, the PANSS scores of the observation group were lower than those of the control group, and the differences were statistically significant (P＜0.05). After 4, 6 and 8 weeks of intervention, the BPRS scores of the observation group were lower than those of the control group, and the differences were statistically significant (P＜0.05). After 8 weeks of intervention, the PSQI score of the observation group was lower than that of the control group, and the difference was statistically significant (P＜0.05). Conclusion Baduanjin intervention in schizophrenia patients can improve clinical symptoms, promote physical and mental rehabilitation, improve sleep quality, which is worthy of clinical attention.
		2022 Vol. 29 (16): 115-117 [Abstract] ( 24 ) HTML (1 KB) PDF (0 KB) ( 11 )

	118	Effects of computer cognitive correction on executive function and alexithymia in patients with schizophrenia
		HUANG Donghua； SUN Yingfang； GUO Huiyun； MAO Zhongzhen； DENG Rubin；LIU Huazhi
		Objective To study the effect of computer cognitive correction on executive function and alexithymia in patients with schizophrenia. Methods A total of 120 schizophrenic patients treated in Ganzhou Third People′s Hospital from June 2019 to June 2021 were selected as the study subjects, and they were divided into study group (60 cases)and control group (60 cases) by sortition randomization method. The control group was treated with routine treatment intervention, and the study group was treated with computer cognitive correction. The clinical efficacy, positive and negative symptom scale scores (PANSS), repeatable battery for the assessment of neuropsychological status (RBANS)and Toronto alexithymia scale (TAS-26) were compared between the two groups. Results The total effective rate of the study group was higher than that of the control group, the difference was statistically significant (P＜0.05). After treatment, the scores of PANSS scale in the study group were lower than those in the control group, the differences were statistically significant (P＜0.05). After treatment, the scores of RBANS in the study group were higher than those in the control group, the differences were statistically significant (P＜0.05). After treatment, the scores of TAS-26 in the study group were lower than those in the control group, the differences were statistically significant (P＜0.05). Conclusion Computer cognitive correction has a significant therapeutic effect on schizophrenic patients. It can improve patients′symptoms, improve patients′ executive function and reduce patients′ alexithymia. It has good clinical application value and can be further popularized.
		2022 Vol. 29 (16): 118-121转125 [Abstract] ( 24 ) HTML (1 KB) PDF (0 KB) ( 13 )

	122	Application effect of mirror therapy combined with music intervention in patients with acute ischemic stroke
		CHEN Xiang； HE Lili； HE Zhenyan
		Objective To explore the effect of mirror therapy combined with music intervention in patients with acute ischemic stroke. Methods A total of 64 patients with hemiplegia after acute ischemic stroke admitted to Jiujiang Hospital of Traditional Chinese Medicine from January 2019 to January 2021 were selected as the research objects, they were divided into study group (32 cases) and control group (32 cases) by random number table method. The control group was given routine rehabilitation therapy, and the research group added mirror therapy combined with music on the basis of the treatment plan of the control group. After intervention, the Fugl-Meyer exercise evaluation scale,Brunnstrom grading score and Barthel index score of the two groups were compared. Results The Fugl-Meyer exercise evaluation scale of the study group after treatment was higher than that of the control group, and the difference was statistically significant (P＜0.05). The Brunnstrom grading score of the study group after treatment was better than the control group, and the difference was statistically significant (P＜0.05). The modified Barthel index score of the study group after treatment was higher than the control group, and the difference was statistically significant (P＜0.05). Conclusion The mirror therapy combined with music intervention can effectively improve the treatment effect of patients with acute ischemic stroke.
		2022 Vol. 29 (16): 122-125 [Abstract] ( 24 ) HTML (1 KB) PDF (0 KB) ( 8 )

	126	Clinical effect of infratemporal transtentorial microsurgery in the treatment of hypertensive brainstem hemorrhage
		LENG Jingxing； LIU Shiheng； XIANG Hui
		Objective To investigate the clinical effect of subtemporal transtentorial approach in the treatment of hypertensive brainstem hemorrhage. Methods Fifty patients with hypertensive brainstem hemorrhage admitted to Jiangxi Provincial People′s Hospital from January 2018 to March 2021 were selected as the research objects and divided into the control group and the research group according to the random number table method, with 25 cases in each group.The control group was treated with conservative treatment, while the study group was treated with subtemporal transtentorial approach. The complication rate, mortality, hospital stay, National Institutes of Health scale score (NIHSS), Glasgow outcome score (GOS) and treatment effect were compared between the two groups. Results The mortality and complication rates of the study group were lower than those of the control group, and the differences were statistically significant (P＜0.05). The hospital stay of the study group was shorter than that of the control group, the NIHSS score was lower than that of the control group, the GOS score was higher than that of the control group, the differences were statistically significant (P＜0.05). The total effective rate of the study group was 88.0%, which was higher than that of the control group (68.0%), and the difference was statistically significant (P＜0.05). Conclusion Compared with conservative treatment, the treatment effect of infratemporal transtentorial approach in patients with hypertensive brainstem hemorrhage is better, which can effectively improve the treatment effect, reduce the risk of complications and mortality, and improve the neurological functional impairment and prognostic effect, shortening the length of hospital stay, it is worth popularizing and applying.
		2022 Vol. 29 (16): 126-128转132 [Abstract] ( 25 ) HTML (1 KB) PDF (0 KB) ( 11 )

	129	Analysis of related factors of drug compliance in rehospitalized schizophrenia patients
		WANG Hongjie； ZHU Lingqun； WANG Zhimin；LI Xianbin；ZHANG Yuxia；SUN Yanping；TAN Liping； XIA Lijie
		Objective To explore the related factors of drug compliance in rehospitalized patients with schizophrenia.Methods A total of 180 cases of hospitalized patients with schizophrenia′s age, gender, duration, marriage, employment, cultural degree, family history, living environment, the types of drugs, self-knowledge, severe mental illness risk grading, medication, economic situation, disability identification information free of charge from May 2016 to May 2018 in Huairou Anjia Hospital, Beijing were retrospective analysed. The Morisky adherence questionnaire (MAQ-8) was applied, and the adherence score＜6 was divided into the poor adherence group (112 cases), score of 6-8 points was divided into the adherence group (68 cases). Logistic regression analysis were used to explore the related factors of drug compliance in rehospitalized patients with schizophrenia. Results The single factor analysis showed that employment status, living environment, drug type, self-awareness and risk of severe mental illness were the influencing factors of poor compliance of re-hospitalized patients the differences were statistically significant (P＜0.05). Logistic regression analysis showed that lack of self-awareness (β=1.338, OR=3.811, 95%CI=2.362-6.148), risk rating of severe mental illness grade≥2 (β=1.213, OR=3.363, 95%CI=1.558-7.262) were independent risk factors for medication compliance of rehospitalized schizophrenia patients (P＜0.05). Conclusion The worse the self-awareness of patients with schizophrenia is, the worse the compliance is. The higher the risk assessment grade of severe mental illness is, the worse the compliance is. Therefore, clinical medical staff should pay attention to the self-awareness of patients and timely assess the risk grade of severe mental illness, which will help to improve the treatment compliance of patients.
		2022 Vol. 29 (16): 129-132 [Abstract] ( 25 ) HTML (1 KB) PDF (0 KB) ( 11 )

	133	Application effects of transcranial magnetic stimulation combined with Olanzapine on mental symptoms and sleep disorders in vagrant patients
		ZHANG Liping；ZHENG Yuling；MO Yingxue
		Objective To investigate the effect of transcranial magnetic stimulation (TMS) combined with Olanzapine in vagrant psychiatric patients. Methods A total of 76 patients with vagrant psychosis treated in Dongguan Seventh People′s Hospital from January 2019 to September 2021 were selected as the study subjects, and they were divided into control group (38 cases) and observation group (38 cases) by random number table method. The control group was treated with Olanzapine and the observation group was treated with TMS for 4 weeks. Mental symptoms (positive and negative symptom scale[PANSS]scores),sleep quality(Pittsburgh sleep quality scale[PSQI])and adverse reactions were compared between the two groups. Results There was no significant difference in PANSS and PSQI scores between the two groups before treatment (P＞0.05). The negative symptoms, positive symptoms, general psychopathological score, PANSS total score and PSQI score of the two groups after treatment were lower than those before treatment, with statistical significances (P＜0.05). The negative symptoms, positive symptoms, general psychopathological score, PANSS total score and PSQI score in the observation group were lower than those in the control group, the differences were statistically significant (P＜0.05). The total effective rate of the observation group (92.11%) was higher than that of the control group(63.16%), with statistical significance (P＜0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P＞0.05). Conclusion TMS combined with Olanzapine in the treatment of vagrant psychosis can effectively improve their mental symptoms and sleep disorders. It has definite curative effect and high safety.
		2022 Vol. 29 (16): 133-135 [Abstract] ( 24 ) HTML (1 KB) PDF (0 KB) ( 15 )

	136	Correlation between serum lipid, calcium and phosphorus and hS-CRP level in hemodialysis patients with microinflammation
		LYU Junzhi
		bjective To explore the correlation between metabolism of blood lipid, calcium, and phosphorus and highsensitivity C-reactive protein (hs-CRP) level in hemodialysis patients at the micro-inflammatory state. Methods Fiftyeight patients with microinflammation who received hemodialysis treatment in the Second People′s Hospital of Shanwei from January 2019 to April 2020 were selected as the dialysis group, and 60 healthy volunteers who received physical examination during the same period were selected as the control group. hs-CRP, urine protein, serum creatinine (SCr),blood urea nitrogen (BUN), triglyceride (TG), serum total cholesterol (TC), high density lipoprotein cholesterol (HDL),low density lipoprotein cholesterol (LDL), blood calcium, blood phosphorus and parathyroid hormone (PTH) were compared between the two groups. The correlation of blood lipid, calcium and phosphorus with hs-CRP was analyzed. Results The levels of hs-CRP, SCr, BUN, TC, blood calcium, blood phosphorus, calcium phosphorus product and PTH in dialysis group were higher than those in control group, while HDL was lower than control group, the differences were statistically significant (P＜0.05). There were no significant differences in TG and LDL levels between the two groups(P＞0.05). There was no correlation between serum lipid, calcium and phosphorus levels and hs-CRP in hemodialysis patients (P＞0.05). Conclusion When long-term hemodialysis patients are in a micro-inflammatory state, there are certain abnormalities in blood lipid levels and calcium and phosphorus levels, but the abnormal conditions are not significantly related to hs-CRP.
		2022 Vol. 29 (16): 136-139 [Abstract] ( 26 ) HTML (1 KB) PDF (0 KB) ( 12 )

	140	Effect of exercise rehabilitation on nutritional status and fatigue syndrome in maintenance hemodialysis patients
		CAI Guomei； HU Jingwen； WANG Quanrui； GAO Yun； FENG Chao； WU Wenbin； CHANG Lingling；CHAI Chunxiang
		Objective To investigate the effects of exercise rehabilitation on nutritional status and fatigue syndrome in patients with maintenance hemodialysis (MHD). Methods A total of 88 patients with maintenance hemodialysis admitted to Affiliated Hospital of Weifang Medical College and Weifang Yidu Central Hospital from June 2019 to October 2020 were selected as the research objects, and were divided into exercise group (n=44) and control group (n=44) according to random number table method. The control group received routine intervention, and the exercise group received exercise rehabilitation during hemodialysis. The clinical indicators (Kt/vurea [Kt/V], hemoglobin [Hb], bicarbonate [HCO3-], serum albumin [Alb]) and constitution-related factors (triceps skinfold thickness [TSF], mid-upper arm circumference [MAC], mid -arm muscle circumference[MAMC], hand gripping strength [HGS], body mass index[BMI], lean tissue mass [LTM], fatigue assessment instrument [FAI] score) of the two groups were compared before and after treatment. Results There were no significant differences in Kt/V and HCO3- between the two groups before and after intervention (P＞0.05). After intervention, Hb and Alb in the exercise group were higher than those in the control group, with statistical significances(P＜0.05). There was no significant difference in TSF between two groups before and after intervention (P＞0.05). After intervention, MAC, MAMC, HGS, BMI and LTM in the exercise group were higher than those in the control group,while FAI was lower than that in the control group, with statistical significances (P＜0.05). Conclusion Exercise rehabilitation can improve the nutritional status of patients and alleviate the symptoms of fatigue syndrome.
		2022 Vol. 29 (16): 140-143转147 [Abstract] ( 24 ) HTML (1 KB) PDF (0 KB) ( 16 )

	144	Effect comparison of internal and external drainage of renal pelvis decompression in the treatment of emergency ureteral calculi obstruction complicated with urinary sepsis
		PENG Yeping；FENG Zhenhua；HUANG Qiang；LIANG Hao；CHEN Xianguo
		Objective To compare the effect of percutaneous nephrostomy (PCN) external drainage and transurethral ureteral stenting (US) internal drainage in the treatment of emergency ureteral calculi obstructive urinary sepsis.Methods A total of 102 patients with emergency ureteral calculi obstruction complicated with urinary sepsis in Gaozhou People′s Hospital from March 2018 to March 2021 were selected as the research objects, and the patients were divided into the external drainage group (52 cases) and the internal drainage group (50 cases) according to the simple randomization method. The external drainage group was treated with PCN, and the internal drainage group was treated with US.The success rate of renal pelvis decompression, infection control, surgical complications and postoperative quality of life were compared between the two groups. Results There were no significant differences between the two groups in the success rate of renal pelvis decompression, the time of body temperature returning to normal, the time of white blood cell (WBC) returning to normal, the time of C-reactive protein returning to normal, the time of procalcitonin (PCT) returning to normal and the days of postoperative hospitalization (P＞0.05). There were no significant differences in the incidence of ureteropelvic stent perforation and renal hemorrhage between the two groups (P＞0.05). The incidence of postoperative back pain and sleep idsorders of the internal drainage group was lower than that in the external drainage group, and the difference was statistically significant (P＜0.05). The infection progression rate at 2 h after operation in the internal drainage group was higher than that in the external drainage group, the difference was statistically significant (P＜0.05). Conclusion Both methods of renal pelvis decompression can effectively control ureteral calculi obstruction complicated with urinary sepsis, but the safety of PCN is better than that of US, and the comfort and quality of life after US are better than those after PCN. Therefore, in terms of treatment, it is necessary to consider the situation of patients and the technology of doctors, and choose the appropriate way of renal pelvis decompression.
		2022 Vol. 29 (16): 144-147 [Abstract] ( 25 ) HTML (1 KB) PDF (0 KB) ( 12 )

	148	Effect of Sacubitril Valsartan in the treatment of chronic left heart failure in patients with peritoneal dialysis
		ZHENG Jiaqi ；SHEN Mingjing
		Objective To investigate the clinical effect of Sacubitril Valsartan in the treatment of chronic left heart failure in patients with peritoneal dialysis. Methods A total of 60 peritoneal dialysis patients with chronic left heart failure who were followed up in Peritoneal Dialysis Center of Central Hospital of Longgang District in Shenzhen City from April 2017 to April 2021 were selected as the subjects for retrospective analysis. According to different treatment plan,they were divided into the observation group (n=30) and the control group (n=30). The observation group was treated with Sacubitril Valsartan, and the control group was treated with Valsartan. Both groups were treated for 6 months. The total effective rates, blood pressure, left ventricular ejection fractions (LVEF) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels were compared between the two groups. Results After 6 months of treatment, the total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P＜0.05). There were no significant differences in systolic blood pressure and diastolic blood pressure between the two groups after treatment (P＞0.05). The LVEF of the observation group after treatment was higher than that of the control group, and the difference was statistically significant (P＜0.05). The level of NT-proBNP in the observation group after treatment was lower than that in the control group, and the difference was statistically significant (P＜0.05). Conclusion Sacubitril Valsartan can effectively treat chronic left heart failure in patients with peritoneal dialysis.
		2022 Vol. 29 (16): 148-151 [Abstract] ( 30 ) HTML (1 KB) PDF (0 KB) ( 13 )

	152	Clinical effect of Tiotropium Bromide Inhalation on patients with chronic bronchitis
		LI Juan； LUO Meifeng； LI Fengyuan； HUANG Jian′ge； WU Ting； XU Yanfang
		Objective To investigate the clinical effect of Tiotropium Bromide Inhalation in the treatment of chronic bronchitis. Methods A total of 45 patients with chronic bronchitis treated in the Department of Respiratory of the First Hospital of Nanchang City from January to December 2018 were selected as the research objects. They were divided into 22 cases in the control group and 23 cases in the study group by odd even grouping method. The control group was treated with routine treatment. The study group was given Tiotropium Bromide Inhalation on the basis of routine treatment. The clinical efficacy, pulmonary function, arterial partial pressure of oxygen and adverse reactions were compared between two groups. Results The total effective rate of clinical efficacy, forced expiratory volume in the first second(FEV1)/forced vital capacity (FVC), FEV1, peak expiratory flow (PEF) and arterial oxygen partial pressure in the study group were higher than those in the control group, with statistically significant differences (P＜0.05). One patient in the study group had dry mouth side effect during medication. Conclusion Tiotropium Bromide Inhalation can improve clinical symptoms, pulmonary function and arterial partial pressure of oxygen in patients with chronic bronchitis, and the incidence of adverse reactions is low.
		2022 Vol. 29 (16): 152-154转165 [Abstract] ( 25 ) HTML (1 KB) PDF (0 KB) ( 13 )

	155	Effect of Ecabet Sodium combined with Cimetidine on serum peptide hormones and cytokines in patients with gastric ulcer
		GUO Yanfen； SU Zhiyu ；XIAO Meihua
		Objective To investigate the effect of Ecabet Sodium combined with Cimetidine on the levels of serum peptide hormones and cytokines in patients with gastric ulcer. Methods A total of 82 patients with gastric ulcer in Zhongshan Chen Xinghai Hospital from February 2020 to August 2021 were selected as the study subjects and divided into control group (41 cases) and observation group (41 cases) by random number table method. The control group was treated with Cimetidine, and the observation group was treated with Ecabet Sodium for 4 weeks. The clinical efficacy, serum peptide hormones (motilin [MTL], gastrin [GAS], somatostatin [SS]), cytokine levels (vascular endothelial growth factor[VEGF], epidermal growth factor [EGF], interleukin-1 [IL-1]) and the total incidence of adverse reactions were compared between the two groups. Results The total effective rate of treatment in the observation group was higher than that in the control group, the difference was statistically significant (P＜0.05). After treatment, the serum MTL and GAS in the observation group were lower than those in the control group, SS, VEGF, and RGF were higher than those in the control group, and IL-1 was lower than that in the control group, the differences were statistically significant (P＜0.05).There was no statistical difference in the total incidence of adverse events between the two groups (P＞0.05). Conclusion Ecabet Sodium combined with Cimetidine in the treatment of gastric ulcer can effectively improve the levels of serum peptide hormones and cytokines in patients, improve clinical efficacy, and is safe and reliable.
		2022 Vol. 29 (16): 155-157 [Abstract] ( 25 ) HTML (1 KB) PDF (0 KB) ( 10 )

	158	Effect of Benazepril combined with Metoprolol Tartrate on blood pressure control and ventricular remodeling in elderly patients with hypertension and heart failure
		CHEN Wei ;SA Cuicui
		Objective To explore the application value of Benazepril combined with Metoprolol Tartrate in elderly patients with hypertension and heart failure. Methods A total of 84 elderly patients with hypertension and heart failure admitted to the Second People′s Hospital of Longkou City from January 2019 to January 2021 were selected as subjects, and divided into a control group (42 cases) and a study group (42 cases) according to the random number table method. The control group was treated with Benazepril, and the study group was treated with Benazepril combined with Metoprolol Tartrate, both of which were treated continuously for 6 months. The blood pressure control effect, ventricular remodeling, heart function, galectin-3 (Gal-3), microalbuminuria (MAU) and adverse reactions were compared between the two groups. Results Before treatment, there were no statistical significances in diastolic blood pressure (DBP), systolic blood pressure (SBP), left ventricular posterior wall thickness (LVPWT), left ventricular mass index (LVMI), interventricular septal thickness (IVST), left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter(LVEDD), left ventricular end-systolic dimension (LVESD), Gal-3, MAU between the two groups (P＞0.05). After treatment, the DBP, SBP, LVPWT, IVST, LVEDD, LVESD, Gal-3 and MAU of the study group were lower than those of the control group, and LVMI and LVEF of the study group were higher than those of the control group, the differences were statistically significant (P＜0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P＞0.05). Conclusion Benazepril combined with Metoprolol Tartrate can effectively control blood pressure in elderly patients with hypertension and heart failure, improve ventricular remodeling, reduce Gal-3 and MAU levels, and promote the recovery of cardiac function in patients, which is safe and reliable.
		2022 Vol. 29 (16): 158-161 [Abstract] ( 25 ) HTML (1 KB) PDF (0 KB) ( 13 )

	162	Influence of traditional Chinese medicine fumigation combined with moxibustion on quality of life in patients with chronic renal insufficiency
		YANG Yongjun
		Objective To study the influence of traditional Chinese medicine fumigation combined with moxibustion on the quality of life of patients with chronic renal insufficiency. Methods A total of 100 patients with chronic renal insufficiency admitted to Wuxi Hospital of Traditional Chinese Medicine from March 2020 to February 2021 were selected as the research objects, and they were divided into the control group (50 cases) and the observation group (50 cases)according to the random number table method. The control group was treated with conventional Western medicine, and the observation group was treated with traditional Chinese medicine fumigation therapy combined with moxibustion on the basis of the control group. The changes of renal blood flow indexes between the two groups were compared, the improvement of the quality of life of the two groups of patients was studied. Results There were no significant differences in peak systolic velocity (PSV), end diastolic velocity (EDV) and resistance index (RI) between the two groups before treatment (P＞0.05). After 2 months of treatment, the EDV level of the observation group was higher than that of the control group, and the RI level of the observation group was lower than that of the control group, the differences were statistically significant (P＜0.05). There was no significant difference in PSV level between the two groups after 2 months of treatment (P＞0.05). There were no significant differences in the scores of energy, physical pain, emotional function, physiological function, physiological function, social function, emotional health and overall health between the two groups before treatment (P＞0.05). After 2 months of treatment, the scores of energy, physical pain, emotional function, physiological function, physiological function, social function, emotional health and overall health in the observation group were higher than those in the control group, and the differences were statistically significant (P＜0.05). Conclusion Traditional Chinese medicine fumigation combined with moxibustion can improve renal arterial blood flow and improve the quality of life of patients. It is a promising Chinese medicine method that is worth recommending.
		2022 Vol. 29 (16): 162-165 [Abstract] ( 27 ) HTML (1 KB) PDF (0 KB) ( 11 )

	166	Application effect of indirect moxibustion at Shenque acupoint in pneumoconiosis patients with phlegm-dampness obstructing lung
		SONG Yufeng ;KONG Fanxiao; FU Chunsheng
		Objective To explore the clinical efficacy of indirect moxibustion at Shenque acupoint in pneumoconiosis patients with phlegm-dampness obstructing lung. Methods A total of 80 pneumoconiosis patients with phlegm-dampness obstructing pulmonary who were admitted to the Department of Rehabilitation Medicine of the Second People′s Hospital of Shaoguan City from July 2018 to June 2020 were selected as the research subjects. They were divided into a treatment group (n=40) and a control group (n=40) by random number table method. Patients in the control group was treated with Western medicine, and in the treatment group, indirect moxibustion at Shenque acupoint was additionally used. Both groups were treated continuously for 15 d. The time of symptoms disappearance, blood oxygen saturation, 6-min walk distance (6MWD), and pulmonary function indexes such as forced vital capacity (FVC), forced expiratory volume in one second (FEV1), and proportion of FEV1 and FVC (FEV1/FVC), were compared between the two groups. Results The disappearance time of pulmonary rales ([5.13±1.30] d), disappearance time of cough ([7.06±1.12] d), and disappearance time of expectoration ([4.25±0.64] d) in the treatment group were shorter than those in the control group([9.86±1.25], [9.57±1.30], [9.16±0.92] d), respectively, with statistically significant differences (P＜0.05). After treatment,the blood oxygen saturation in the treatment group was (97.86±2.04)%, higher than that of the control group ([95.02±2.11]%), 6MWD in the treatment group ([602.45±15.73] m) was longer than that of the control group ([500.69±12.68] m),FEV1([2.19±0.44] L) and FEV1/FVC ([88.69±2.57]%) in the treatment group were higher than those of the control group([1.86±0.42] L and [76.70±3.35]%), with statistically significant differences (P＜0.05). There was no significant difference in FVC level between the two groups after treatment (P＞0.05). Conclusion Indirect moxibustion at Shenque acupoint in pneumoconiosis patients with phlegm-dampness obstructing lung is conducive to shorten the disappearance time of various symptoms, improve blood oxygen saturation, and enhance cardiopulmonary function, which is worthy of promotion.
		2022 Vol. 29 (16): 166-169 [Abstract] ( 30 ) HTML (1 KB) PDF (0 KB) ( 12 )

	170	Clinical effect of fire dragon-like cupping combined with acupoint application in the treatment of Yang-deficiency induced insomnia
		XIONG Chunhong;PENG Jing ;LI Yanli; XIONG Bingjie ;TANG Luoman ;TAN Yu ;XIA Lang ;WU Gangqiang
		Objective To explore the efficacy and safety of fire dragon-like cupping combined with acupoint application in the treatment of Yang-deficiency induced insomnia. Methods The clinical data of 65 patients with Yang-deficiency type insomnia hospitalized in the Affiliated Hospital of Hu′nan Academy of Traditional Chinese Medicine from August 2020 to August 2021 were analyzed retrospectively. They were divided into the treatment group (34 cases) and the control group (31 cases) according to different treatment methods. Patients in the control group were treated with Estazolam in oral administration, and the treatment group was treated with fire dragon-like cupping combined with acupoint application. The Pittsburgh sleep quality index (PSQI) score, clinical efficacy, Yang-deficiency constitution score and the incidence of adverse reactions were observed of patients in the two groups. Results There were no significant differences in the PSQI score and Yang-deficiency constitution score between the two groups before treatment (P＞0.05).The PSQI scores and Yang-deficiency constitution scores in the two group after treatment were both lower than those before treatment, and the PSQI score and Yang-deficiency constitution score in the treatment group after treatment were both lower than those in the control group, with statistical significances (P＜0.05). The total effectiveness rate in the treatment group was higher than that in the control group, and the difference was statistically significant (P＜0.05).The incidence of adverse reactions in the treatment group after treatment was lower than that in the control group, and the difference was statistically significant (P＜0.05). Conclusion The clinical effect of fire dragon-like cupping combined with acupoint application in the treatment of insomnia patients with Yang-deficiency type is better, with little side effects, which is worthy of popularization.
		2022 Vol. 29 (16): 170-173 [Abstract] ( 25 ) HTML (1 KB) PDF (0 KB) ( 11 )

	174	Effect of dietary behavior and management on blood pressure control in hypertensive patients
		ZHU Shan1 TANG Yao1 LIN Hao； WANG Hanqing； ZHANG Yanping； ZHANG Wenchang；ZHANG Chenyun
		Objective To investigate the influence of dietary behavior and management on blood pressure control in hypertensive patients. Methods A total of 591 patients with hypertension in a community in Fuzhou, Fujian Province from April 2017 to April 2018 were retrospectively selected as the research objects. Questionnaire survey on eating habits was conducted. On the basis of univariate analysis, the results were analyzed by multivariate logistic regression.Results The results of univariate analysis showed that dietary behavior management, medical insurance, smoking, taste preference, frequent consumption of picckled and smoked food, salt consumption, oil consumption, meat consumption,fruit and vegetable consumption, soy products and nuts consumption were related factors affecting blood pressure control, the differences were statistically significant (P ＜0.05). Education level, dietary guidance, whether they had participated in dietary behavior management activities and lectures, whether their families and friends had conducted dietary behavior management, and whether they had been aware of the relationship between dietary behavior and hypertension were related factors that affecting dietary behavior management, the differences were statistically significant (P ＜0.05). The results of multivariate analysis showed that no dietary behavior management, frequent consumption of pickled and smoked food, high consumption of salt and oil, low consumption of vegetables and fruits,soy products and nuts were independent risk factors for poor blood pressure control (OR＞1, P＜0.05). Not received dietary guidance, not participated dietary behavior management activities and lectures, family and friends not taking dietary behavior management were independent risk factors that affect patients′ dietary behavior management (OR＞1,P＜0.05). Conclusion Good dietary behaviors such as low-salt and low-oil diet and moderate consumption of fruits and vegetables are conducive to blood pressure control of patients with hypertension, and dietary behavior management level of patients can improve through community lectures and health education of family and friends.
		2022 Vol. 29 (16): 174-177 [Abstract] ( 24 ) HTML (1 KB) PDF (0 KB) ( 15 )

	178	Analysis and discussion on the regularity of traditional Chinese medicine clinical prescription decoction pieces in Longnan First People′s Hospital
		YANG Gaoju ；CHEN Hui； JIAO Yunhui ；CHEN Zhizhen
		Objective Based on the cloud platform of ancient and modern medical records, this paper studies the rules of traditional Chinese medicine clinical prescription decoction pieces in Longnan First People′s Hospital, and provide reference for the medication specification requirements for compiling the prescription of traditional Chinese medicine decoction pieces in Longnan First People′s Hospital. Methods The prescriptions of clinical decoction pieces of traditional Chinese medicine in Longnan First People′s Hospital from January 2020 to January 2021 were collected. The hospital information system (HIS) was used for statistical inquiry, sorting out, screening and standardized processing,the database of traditional Chinese medicine clinical prescription decoction pieces in Longnan First People′s Hospital was established, the frequency analysis, dosage interval analysis of decoction pieces, and dosage point analysis of decoction pieces were performed using the cloud platform of ancient and modern medical records, and the medication rules such as four natures, five flavors, channel tropism and efficacy of traditional Chinese medicine clinical prescription decoction pieces in Longnan First People′s Hospital were analyzed. Results A total of 17 749 traditional chinese medicine clinical prescriptions were included, involving 360 herbs, and the top 100 herbs with the highest frequency of use were statistically analyzed, Codonopsis pilosula, Angelica sinensis, and Roasted Radix Glycyrrhizae were the most frequently used herbs, and warm, flat, and slightly cold were the most frequent natures, the sweet, pungent, and bitter were the most frequent flavors, the herbs mostly entered the lung, spleen, and liver channels, and the clinical dosage were most concentrated at 5, 6, 10, 12, and 15 g. Conclusion Through data mining, it is found that the prescription drugs of traditional Chinese medicine decoction pieces in Longnan First People′s Hospital have strong regional characteristics, and there are some differences with the dosage of Pharmacopoeia, but the overall attributes and dosage rules have certain clinical value.
		2022 Vol. 29 (16): 178-182 [Abstract] ( 23 ) HTML (1 KB) PDF (0 KB) ( 11 )

	183	Application effect of pressing acupuncture in patients with severe cerebral hemorrhage
		HU Jian； JIANG Yingying
		Objective To explore the application effect of pressing acupuncture in patients with severe cerebral hemorrhage. Methods A total of 60 patients with severe cerebral hemorrhage who were admitted in the Jiujiang First People′s Hospital from December 2020 to November 2021 were selected as research subjects, and they were divided into the observation group (n=30) and the control group (n=30) by random ball-touching method. The control group was received pure nasogastric standard enteral nutrient solution, and the observation group was received screw acupuncture on the basis of the control group. The incidence of enteral nutrition-related diarrhea, nutritional indicators and length of intensive care unit (ICU) stay were compared between the two groups. Results The incidence of enteral nutrition-related diarrhea in the observation group was lower than that in the control group, the difference was statistically significant(P＜0.05). After intervention, the levels of transferrin (TRF), hemoglobin (Hb) and prealbumin (PAB) in the two groups were higher than those before intervention, and the levels of TRF, Hb and PAB in the observation group were higher than those in the control group, the differences were statistically significant (P＜0.05). The length of ICU stay in the observation group was shorter than that in the control group,the difference was statistically significant(P＜0.05).Conclusion In severe patients with intracerebral hemorrhage,the treatment of screw acupuncture can effectively prevent enteral nutrition-related diarrhea,significantly regulate the nutritional indicators,and shorten the ICU hospitalization time of patients.
		2022 Vol. 29 (16): 183-185 [Abstract] ( 24 ) HTML (1 KB) PDF (0 KB) ( 7 )

	186	Application effect of continuous nursing on patients with chronic sinusitis undergoing functional endoscopic sinus surgery
		MAI Xiaochun；WANG Yayan ；LIN Yuting
		Objective To explore the application effect of continuous nursing on patients with chronic sinusitis undergoing functional endoscopic sinus surgery. Methods A total of 60 patients with chronic sinusitis treated in Shanwei Second People′s Hospital between January 2020 and July 2021 were selected as the research objects, and they were divided into observation group (30 cases) and control group (30 cases) by the random number table method. Both groups required functional endoscopic sinus surgery, and the control group was given routine postoperative nursing while the observation group was additionally given continuous nursing for intervention on this basis. At 3 months after intervention,the rehabilitation status and review results of nasal endoscopy were compared between the two groups of patients. The nasal cavity irrigation compliance of the two groups was compared before and after intervention. Results At 3 months after intervention, the total effective rate of rehabilitation and the abnormal rate of review results of nasal endoscopy of patients in observation group were lower than those in control group at the same time point, the differences were statistically significant (P＜0.05). The total nasal cavity irrigation compliance at 3 months after intervention in observation group was higher than that in control group, the difference was statistically significant (P＜0.05). Conclusion The application of continuous nursing in the rehabilitation nursing of patients with chronic sinusitis undergoing functional endoscopic sinus surgery can enhance the nasal cavity irrigation compliance and effectively improve the rehabilitation status of patients.
		2022 Vol. 29 (16): 186-189 [Abstract] ( 26 ) HTML (1 KB) PDF (0 KB) ( 15 )

	190	Application effect of accelerated rehabilitation surgical nursing in patients with drug-refractory epilepsy during perioperative period
		MENG Ronghui； FAN Yu； WANG Zhanran
		Objective To investigate the application effect of accelerated rehabilitation surgical nursing in patients with drug-refractory epilepsy during perioperative period. Methods A total of 255 patients with refractory epilepsy who underwent surgery in Beijing Fengtai Hospital from January 2018 to December 2020 were selected as the research objects, and they were divided into observation group (128 cases) and control group (127 cases) according to the random ball-touching method. Control group was given routine perioperative nursing, observation group was given accelerated rehabilitation surgical nursing. The stress indexes of the two groups before and after operation were observed and compared. The clinical indicators of the two groups were compared. Results The levels of white blood cell (WBC), cortisol(Cor) and C-reactive protein (CRP) in observation group were lower than those in control group, the differences were statistically significant (P＜0.05). In the observation group, the early postoperative feeding time, postoperative catheter removal time, postoperative ambulation time and hospitalization time were shorter than those in the control group, and the hospitalization cost was lower than that in the control group, with statistically significant differences (P＜0.05). Conclusion Perioperative nursing intervention of accelerated rehabilitation surgery in patients with refractory epilepsy has a better effect, which can improve patients′ symptoms, shorten postoperative feeding time, catheter removal time, hospital stay and reduce hospitalization costs, which is worthy of clinical application
		2022 Vol. 29 (16): 190-192转196 [Abstract] ( 27 ) HTML (1 KB) PDF (0 KB) ( 12 )

	193	Application of medical-patient integrated nursing on patients with skin and soft tissue defects in limbs and free flap transplantation
		LIU Ping
		Objective To observe the intervention effect of medical-patient integrated nursing on patients with skin and soft tissue defect of limbs and free flap transplantation. Methods A total of 68 patients who received treatment with skin and soft tissue defect of limbs and free flap transplantation in Jianli Hospital of Traditional Chinese Medicine from January 2018 to June 2019 were selected as the research objects, and divided into observation group and control group according to random number table method, with 34 patients in each group. The control group received routine nursing,and the observation group received medical-patient integrated nursing. The treatment compliance rate, health knowledge awareness rate, success rate of skin flap transplantation, treatment satisfaction, complication rate, pain score at 1 and 2 weeks after operation and wound healing time of the two groups were compared. Results The rate of health knowledge mastery, the success rate of skin flap transplantation, the rate of treatment compliance and nursing satisfaction in the observation group were higher than those in the control group, the total incidence of complications and pain scores at 1 and 2 weeks after operation were lower than those in the control group, and the wound healing time was shorter than that in the control group, the differences were statistically significant (P＜0.05). Conclusion The medicalpatient integrated nursing model has important clinical application significance in the nursing of patients after free flap transplantation and repair, and is worth popularizing.
		2022 Vol. 29 (16): 193-196 [Abstract] ( 26 ) HTML (1 KB) PDF (0 KB) ( 14 )

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