血管内皮生长因子、糖类抗原125及人附睾蛋白4联合检测在卵巢癌诊断中的价值

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Abstract Objective To investigate the clinical value of combined detection of vascular endothelial growth factor(VEGF), carbohydrate antigen 125 (CA125) and human epididymis protein 4 (HE4) in the diagnosis of ovarian cancer.Methods From January 2017 to June 2019, 60 ovarian cancer patients admitted to Taishan District People′s Hospital of Tai′an City were selected as the ovarian cancer group. From January 2017 to June 2019, 60 patients with benign ovarian diseases admitted to Taishan District People′s Hospital of Tai′an City were selected as the benign ovarian diseases group, and 60 healthy women who underwent health check-up from January 2017 to June 2019 at Taishan District People′s Hospital of Tai′an City were selected as the control group. The serum levels of VEGF, CA125 and HE4 were measured, the serum levels of VEGF, CA125 and HE4 were compared among ovarian cancer patients, benign ovarian disease patients and healthy women, the receiver operating characteristic (ROC) curve was used to analyze the diagnostic value of three separate and combined tests for ovarian cancer. Results The levels of VEGF, CA125 and HE4 in ovarian cancer group were higher than those in control group and benign ovarian disease group, and the differences were statistically significant (P＜0.001). The level of VEGF in benign ovarian disease group was higher than that in normal control group, the difference was statistically significant (P＜0.001). There were no statistically significant differences in the CA125 and HE4 levels between benign ovarian disease group and control group (P＞0.05). The serum levels of CA125,VEGF and HE4 in patients with stage Ⅳovarian cancer were higher than those in patients with stage Ⅰ-Ⅱand Ⅲovarian cancer, and the differences were statistically significant (P＜0.05). Serum levels of CA125, VEGF and HE4 in patients with stage Ⅲovarian cancer were higher than those in patients with stage Ⅰ-Ⅱovarian cancer, and the differences were statistically significant (P＜0.05). The sensitivity of VEGF, CA125 and HE4 to ovarian cancer were 85.00%,73.33%, 65.00% respectively. The specificity of VEGF, CA125 and HE4 to ovarian cancer were 79.17%, 68.33% and 89.17% respectively. In VEGF, CA125 and HE4 single test, the diagnostic efficacy of VEGF in ovarian cancer was the highest. The sensitivity and specificity of three combined tests among VEGF, CA125 and HE4 were 71.67% and 91.67% respectively. The test′s sensitivity and specificity of CA125 combined with HE4 were 83.33% and 72.50% respectively. The diagnostic efficacy of three combined tests was higher than that of single test and CA125+HE4 test. The sensitivity and specificity of three combined tests among VEGF, CA125 and HE4 were 84.60% and 93.00% respectively, and the sensitivity and specificity of CA125 combined with HE4 were 81.50% and 76.80% respectively. The diagnostic efficacy of three combined tests was higher than that of CA125+HE4. Conclusion The combined determination of CA125 and serum HE4 and VEGF improves the diagnosis of ovarian epithelial cancer, especially for early ovarian cancer diagnosis.

Key words： Vascular endothelial growth factor Carbohydrate antigen 125 Human epididymis protein 4 Ovarian cancer

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LIU Xuebo. Value of combined detection of vascular endothelial growth factor, carbohydrate antigen 125 and human epididymis protein 4 in the diagnosis of ovarian carcinoma[J]. 中国当代医药, 2022, 29(16): 35-38转48.

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https://www.dangdaiyiyao.com/EN/ OR https://www.dangdaiyiyao.com/EN/Y2022/V29/I16/35

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