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| Influence of Probucol combined with secondary prevention of coronary heart disease on oxidative stress indexes and cardiac function in elderly patients with old myocardial infarction |
| ZHONG Su YU Yan |
| Cadre Ward, Chenggong Hospital Affiliated to Xiamen University |
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Abstract Objective To investigate the influence of Probucol combined with secondary prevention of coronary heart disease on oxidative stress indexes and cardiac function in elderly patients with old myocardial infarction. Methods A total of 86 elderly patients with old myocardial infarction treated in Chenggong Hospital Affiliated to Xiamen University from October 2019 to January 2021 were selected as the research objects. According to random number table method,they were divided into the observation group (43 cases) and the control group (43 cases). The control group was treated with secondary prevention of coronary heart disease, and the observation group was treated with Probucol on the basis of the control group. The oxidative stress indexes (superoxide dismutase [SOD], malondialdehyde [MDA], glutathione peroxidase [GSH-Px]), echocardiographic indexes (left ventricular ejection fraction [LVEF], cardiac output [CO], cardiac output index [CI] and the mean pulmonary artery pressure), cardiac function grade, adverse reactions during treatment were compared between the two groups. Results The levels of SOD and GSH-Px in the two groups after treatment were higher than those before treatment, and the levels of SOD and GSH-Px in the observation group after treatment were higher than those in the control group, the differences were statistically significant (P＜0.05). The MDA levels of the two groups after treatment were lower than those before treatment, and the MDA level of the observation group after treatment was lower than that of the control group, the differences were statistically significant (P＜0.05). The levels of LVEF, CO and CI in the two groups after treatment were higher than those before treatment, and the levels of LVEF, CO and CI in the observation group after treatment were higher than those in the control group, the differences were statistically significant (P＜0.05). The levels of mean pulmonary artery pressure of the two groups after treatment were lower than those before treatment, and the mean pulmonary artery pressure of the observation group after treatment was lower than that of the control group, the differences were statistically significant (P＜0.05). The cardiac function grading of the two groups after treatment was better than that before treatment, and the cardiac function grading of the observation group after treatment was better than that of the control group, the differences were statistically significant (P＜0.05). There was no significant difference in the total incidence of adverse reactions between the two groups during treatment (P＞0.05). Conclusion Probucol combined with secondary prevention of coronary heart disease can significantly reduce the level of oxidative stress, improve cardiac function and prognosis in elderly patients with old myocardial infarction, and has good safety.
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