达格列净在2型糖尿病肾病中的应用效果

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Abstract Objective To explore the application effect of Dapagliflozin in type 2 diabetic kidney disease. Methods A total of 40 patients with type 2 diabetic kidney disease admitted to the Department of Nephrology, Suqian Hospital,Nanjing Gulou Hospital Group from July 2020 to July 2021 were selected as the research subjects. They were divided into control group (n=20) and observation group (n=20) by random number table method. The control group was treated with hypoglycemic drugs besides Dapagliflozin, while the observation group was treated with Dapagliflozin 10 mg once a day. Both groups were given diet control and exercise intervention. The body mass index (BMI), systolic blood pressure(SBP), diastolic blood pressure (DBP), serum fasting glucose (FPG), glycosylated hemoglobin (HbA1c), total cholesterol(TC), triglyceride (TG), high density lipoprotein (HDL), low density lipoprotein (LDL), serum creatinine (SCr), cystatin C(CysC), serum uric acid (SUA), type B brain natriuretic peptide (BNP), estimated glomerular filtration rate (eGFR), urinary protein/creatinine ratio (UACR), 24-hour urinary albumin quantification (24 h UAlb), left ventricular ejection fraction (LVEF) were compared between the two groups before treatment and 12 weeks after treatment. The incidence of adverse reactions was compared between the two groups. Results After 12 weeks of treatment, FPG, HbA1c, UACR,24 h UAlb, SUA and BNP in the observation group were lower than those before treatment, while LVEF in the observation group after 12 weeks of treatment was higher than that before treatment, the differences were statistically significant (P＜0.05). After 12 weeks of treatment, HbA1c, UACR, 24 h UAlb, SUA and BNP in the observation group were lower than those in the control group, while LVEF in the observation group was higher than that in the control group,the differences were statistically significant (P＜0.05). After 12 weeks of treatment, there were no significant differences in SBP, DBP, body weight, BMI, FPG, TC, TG,HDL, LDL, SCr, eGFR and CysC between the two groups(P＞0.05). The incidence of hypoglycemia in observation group was lower than that in control group, and the difference was statistically significant (P＜0.01). There was no significant difference in the incidence of urinary tract infection between the two groups (P＞0.05). The total incidence of adverse reactions in observation group was lower than control group, and the difference was statistically significant (P＜0.05). Conclusion Dapagliflozin can decrease UACR, 24 h UAlb, HbA1c, BNP, SUA and increase LVEF in patients with type 2 diabetic kidney disease, and has protective effect on heart and kidney function in patients with type 2 diabetic kidney disease.

Key words： Dapagliflozin Type 2 diabetic kidney disease Proteinuria Cardiac function

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	Articles by authors
	XU Xiaohong
	ZHANG Ce
	MI Xia
	ZHANG Chi
	ZHOU Feihong
	WANG Junsheng
	ZHU Ai′min

Cite this article:

XU Xiaohong,ZHANG Ce,MI Xia, et al. Application effect of Dapagliflozin in type 2 diabetic kidney disease[J]. 中国当代医药, 2022, 29(16): 5-10.

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https://www.dangdaiyiyao.com/EN/ OR https://www.dangdaiyiyao.com/EN/Y2022/V29/I16/5

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