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| Effect of Benazepril combined with Metoprolol Tartrate on blood pressure control and ventricular remodeling in elderly patients with hypertension and heart failure |
| CHEN Wei SA Cuicui |
| Department of Pharmacy, the Second People′s Hospital of Longkou City |
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Abstract Objective To explore the application value of Benazepril combined with Metoprolol Tartrate in elderly patients with hypertension and heart failure. Methods A total of 84 elderly patients with hypertension and heart failure admitted to the Second People′s Hospital of Longkou City from January 2019 to January 2021 were selected as subjects, and divided into a control group (42 cases) and a study group (42 cases) according to the random number table method. The control group was treated with Benazepril, and the study group was treated with Benazepril combined with Metoprolol Tartrate, both of which were treated continuously for 6 months. The blood pressure control effect, ventricular remodeling, heart function, galectin-3 (Gal-3), microalbuminuria (MAU) and adverse reactions were compared between the two groups. Results Before treatment, there were no statistical significances in diastolic blood pressure (DBP), systolic blood pressure (SBP), left ventricular posterior wall thickness (LVPWT), left ventricular mass index (LVMI), interventricular septal thickness (IVST), left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter(LVEDD), left ventricular end-systolic dimension (LVESD), Gal-3, MAU between the two groups (P＞0.05). After treatment, the DBP, SBP, LVPWT, IVST, LVEDD, LVESD, Gal-3 and MAU of the study group were lower than those of the control group, and LVMI and LVEF of the study group were higher than those of the control group, the differences were statistically significant (P＜0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P＞0.05). Conclusion Benazepril combined with Metoprolol Tartrate can effectively control blood pressure in elderly patients with hypertension and heart failure, improve ventricular remodeling, reduce Gal-3 and MAU levels, and promote the recovery of cardiac function in patients, which is safe and reliable.
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