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Quick Search     Adv Search 2017 Vol. 24, No. 24 Published: 2017-08-28   4 The comparative study of Heparin versus Citrate Anticoagulation for continuous renal replacement therapy rewarming in hypothermia dogs with seawater immersion YUAN Rui, SHUAI Wei-zheng, ZHANG Zhi-cheng Objective To investigate the effect of systemic Heparin anticoagulation or local Citrate anticoagulation on the treatment of sudden hypothermia in beagles with open abdominal trauma and seawater immersion during continuous renal replacement therapy rewarming (CRRT).Methods Nineteen beagles were enrolled in this study.The animal model of open abdominal trauma coupled with hypothermia induced by seawater immersion was established. Dogs were randomly divided into three groups according to rewarming ways:systemic Heparin anticoagulation group (group A,n=7 ),regional Citrate anticoagulation group (group B,n=7),warm water bath rewarming group (group C,n=5).The blood routine,blood chemistry,coagulation function,blood gas and hemodynamics indexes were detected at normal temperature,hypothermia to 34℃,rewarming to 30℃,34℃,38℃.Results There was no significant difference in Fib,K+,TBil and MAP among the three groups at each time point (P>0.05).When rewarming to 34℃ and 38℃,BUN in group C was significantly higher than that in group A and B (P<0.05).Conclusion During the progress of CRRT rewarming,there are no difference between Heparin anticoagulantion or Citrate anticoagulation on Fib,K+,BUN,TBil and MAP for accidental hypothermia dogs with open abdominal trauma and hypothermia induced by seawater immersion. 2017 Vol. 24 (24): 4-4 [Abstract] ( 210 ) HTML (1 KB)  PDF (435 KB)  ( 129 ) 7 Application evaluation of rapid on-site evaluation in endobronchial ultrasound-guided transbronchial needle aspiration ZHANG Lei, YE Lian-hua, CHEN Ying, CHEN Ya, JIN Ping, YANG Cheng-gang, TAN Hui Object To investigate the clinical value of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) combined with rapid on-site evaluation (ROSE) for enlarged hilar/mediastinal lymph nodes.Methods 104 patients with enlarged hilar/mediastinal lymph nodes by chest CT pointing out treated in Yunnan Cancer Hospital from June to December 2016 were randomly divided into the two groups,and they were given EBUS-TBNA,among them,there were 48 cases in on-site cytology group,while there were 56 cases in routine cytology group.Routine cell and histological findings were the gold standard.Results The diagnose rate in on-site cytology group and routine cytology group was 83.33% and 83.93% respectively,and the sonsistency of field cytology group with gold standard:kappa=0.883;the detection rate of malignant lymph nodes was 77.23% and 76.20% respectively,the time of puncture was (31.02±1.05) and (20.98±0.723）min respectively,the number of puncture was (1.57±0.24) times and (3.5±0.35) times,the incidence rate of puncture bleeding was 4.17%,5.37% respectively, secondary inspection rate was 0 and 3.57% respectively,and there was no statistical difference of above-mentioned data between the two groups (P>0.05).Conclusion EBUS-TBNA combined with ROSE in the diagnosis of enlarged hilar/mediastinal lymph nodes is effectively and reliable.The accuracy and gold standard is highly consistent.EBUS-TBNA combine with ROSE can reduce the incidence rate of complication such as puncture bleeding and secondary inspection rate,its safety is higher and it is better than EBUS-TBNA. 2017 Vol. 24 (24): 7-10 [Abstract] ( 276 ) HTML (1 KB)  PDF (439 KB)  ( 211 ) 11 Research progress on reversal of multidrug resistance in leukemia cells by traditional Chinese medicine LIN Ting, LIAO Bin The main reason of causing failure of chemotherapy and disease recurrence is multidrug resistance (MDR).Because the mechanism of tumor cell MDR action is very complex,traditional Chinese medicine can reverse MDR with multiple targets,multiple pathways,low toxicity and high efficiency.As a drug resistance reversal agent,traditional Chinese medicine has become a hot topic that it enhances the sensitivity of drug-resistant tumor cells to chemotherapeutic drugs.This article reviews the research of the complex mechanism of tumor cell MDR and the reversal of MDR by single traditional Chinese medicine and compound traditional Chinese medicine. 2017 Vol. 24 (24): 11-14 [Abstract] ( 274 ) HTML (1 KB)  PDF (414 KB)  ( 213 ) 15 Research progress in risk factors for rebleeding of intracranial aneurysms ZHANG Yi-fu, XIANG Ben-you Intracranial aneurysm rebleeding is a serious complication leading to poor prognosis in patients with aneurysmal subarachnoid hemorrhage.It can lead to high mortality and high disability in patients.The mechanism of rebleeding is influenced by many complex factors.Recent decades of research have identified a number of risk factors associated with rebleeding,such as treatment delay,changes in systolic blood pressure,aneurysm size,fibrinolysis,poor neurological status,hematoma volume,sentinel headache Etc.However,some factors remain controversial,such as genes,sex,aneurysmlocation and so on.This review summarizes the research progress of the risk factors leading to rebleeding and the current prevention of rebleeding. 2017 Vol. 24 (24): 15-18 [Abstract] ( 237 ) HTML (1 KB)  PDF (419 KB)  ( 126 ) 19 Application of the Closed-Sheet Method for individual numbers of testicular spermatozoa cryopreservation MA Chao, HU Ming-guang, JIN Bo Objective To investigate the effect of Closed-Sheet Method on testicular spermatozoa in patients with obstructive azoospermia(OA),in order to provide a simple and effective cryopreservation for individual numbers of testicular spermatozoa in patients with non-obstructive azoospermia(NOA).Methods 15 patients were diagnosed with OA by Reproductive Medicine & Genetic Center of Dalian from June to December 2016.Single testicular spermatozoa was frozen with Closed-Sheet Method,and we compared cleavage rate and fertility rate after ICSI between frozen-thawed individual numbers of testicular spermatozoa and fresh testicular sperm with abandoned in vitro maturation of immature oocytes,and the fertilization rate of frozen-thawed testicular spermatozoa was evaluated.Both frozen and fresh groups were from the above 15 patients.Results The frozen-thawed individual numbers of testicular spermatozoa had higher recovery rate and viability rate(92.00%,65.94%) with the Closed-Sheet Method.The fertility rate (56.00% vs 70.66%)and cleavage rate (97.44% vs 95.83%) of frozen testicular spermatozoa was similar to fresh testicular sperm after ICSI,and no significant difference(P>0.05).Conclusion Since the frozen-thawed testicular spermatozoa had a higher ability of fertilization.The Closed-Sheet Method was effective to cryopreserve individual numbers of testicular spermatozoa in patients with OA.This study laid the experimental basis for the clinical application of single sperm cryopreservation in patients with NOA. 2017 Vol. 24 (24): 19-22 [Abstract] ( 250 ) HTML (1 KB)  PDF (598 KB)  ( 131 ) 22 Analyze the clinical effect of ultra-early minimally invasive puncture and drainage surgery on patients with cerebral hemorrhage in basal ganglia ZHANG Zhong-min, WANG Hai-bo, YUAN Wei, LI Zhao-sheng Objective To analyze the clinical effect of ultra-early minimally invasive puncture drainage operation on patients with cerebral hemorrhage in base subregion.Methods 108 patients with basal ganglia hemorrhage,from October 2015 to October 2016,were divided into two groups,control group (54 patients were used routine treatment),the observation group (54 patients were used super early minimally invasive puncture drainage surgery).Results The patients of observation group after treatment of hematoma size [(35.01±4.15) ml],daily life ability score [(90.18±3.45) scores],loss of neurological function score (85.28±2.19) scores was better than that of control group [(30.20±1.18) ml,(7.29±3.18) scores],(15.45±6.28) scores](P<0.05）,patients of the observation group of recurrence in 4 cases,no recurrence of 50 cases of patients with recurrence,the recurrence rate (7.40%) was lower than that of the control group (18.52%) (P<0.05）.Conclusion Through the treatment of patients with cerebral hemorrhage in the base of base region,it can promote the rapid recovery of patients and deserve further promotion and application. 2017 Vol. 24 (24): 22-24 [Abstract] ( 217 ) HTML (1 KB)  PDF (551 KB)  ( 100 ) 25 Effect of ultra-pulsed carbon dioxide dot laser on atrophic scar LI Jing-si Objective To study the effect of ultra-pulsed CO2 laser in the treatment of atrophic scar.Methods Forty patients with atrophic scar in the Department of Dermatology of our Hospital were enrolled in this study from February to October 2016.The patients were treated with ultra-pulsed CO2 laser.The clinical effects,adverse events,ECCA scores,and skin texture values were observed after 1 month and 3 months of treatment.Results The total effective rate was 75% and 95% after 1 month and 3 months of treatment,the difference was significant (P<0.05).In addition,after treatment,9 patients with hyperpigmentation,the incidence was 22.5%.At the same time,ECCA score and skin texture value of all patients were significantly lower than those before treatment,the differences were significant (P<0.01).Conclusion Ultra-pulsed carbon dioxide treatment can improve the condition of skin lesions of patients with atrophic scar,reduce the incidence of adverse reactions,and the clinical promotion value is higher. 2017 Vol. 24 (24): 25-27 [Abstract] ( 228 ) HTML (1 KB)  PDF (597 KB)  ( 118 ) 28 Comparison of the clinical effect of somatostatin and Pantoprazole sodium in the treatment of severe acute pancreatitis ZHANG Xu Objective To compare the effect of somatostatin and Pantoprazole sodium on severe acute pancreatitis.Methods From October 2016 to May 2017,92 patients with severe acute pancreatitis in our hospital were selected and randomly divided into two groups.The Pantoprazole sodium was provided in both control group and research group.On the basis,somatostatin was added in the research group.The clinical effect in the two groups was compared.Results In the research group,the time to wean from mechanical ventilation was (3.26±1.61) d,the average time of gastrointestinal function recovery was (3.26±1.05) d,and abdominal pain relief time was (2.16±1.56) d,which were all shorter compared with those in the control group [(5.64±1.46),(4.62±1.24),(4.64±1.82) d],the differences were statistically significant (P<0.05);3,6 d after treatment,the APACHE-Ⅱscores of the research group were better than the control group,the differences were statistically significant (P<0.05).Conclusion Combination of Pantoprazole sodium and somatostatin can obtain an optimal effect on treating severe acute pancreatitis. 2017 Vol. 24 (24): 28-30 [Abstract] ( 249 ) HTML (1 KB)  PDF (542 KB)  ( 227 ) 30 Analysis of effectiveness of mammotome minimally invasive surgery and traditional surgery in treatment of breast masses WEN Peng Objective To investigate the mammotome minimally invasive surgery and traditional surgery in treatment of breast masses.Methods Clinical data of 60 patients with benign breast tumor who were treated in department of surgical oncology of our hospital from March 2014 to January 2016 were analyzed retrospectively; and all the patients were divided according to different surgical treatment methods into observation group (30 cases,treatment with mammotome minimally invasive surgery) and control group (30 cases,treatment with traditional surgery).The duration of surgery,bleeding volume,postoperative scar length,healing time,postoperative complications and breast cosmetic effect were observed between two groups of patients with breast masses.Results The duration of surgery,bleeding volume,postoperative scar length and healing time of observation group were lower than those of control group;the postoperative complication rate of local hematoma,infection and deformity of observation group was lower than that of control group;the breast cosmetic effect of observation group was higher than that of control group,with statistically significant difference (P<0.05).Conclusion Mammotome minimally invasive surgery achieves less bleeding,faster recovery,less postoperative complications and better cosmetic effect in the treatment of patients with breast masses,which is worthy of clinical application. 2017 Vol. 24 (24): 30-32 [Abstract] ( 232 ) HTML (1 KB)  PDF (553 KB)  ( 433 ) 33 Analysis of related risk factors for arteriovenous fistula embolization in maintenance hemodialysis patients QIAN Mu-zhou, JIA Wei Objective To observe relevant the risk factors of arteriovenous fistula embolization in maintenance hemodialysis patients.Methods 80 patients with MHD who were given arteriovenous fistula surgery and were given long-term dialysis follow-up in the outpatient from June 2013 to June 2017 were selected as the study subjects.The patients were divided into the embolization group (n=40) and the normal group (n=40) according to whether fistula embolization occurred.The clinical data of patients and relevant indicators of arteriovenous fistula were observed.Linear regression analysis was applied to analyze the relevant risk factors caused by fistula embolization.Results The age factor,complicated diabetes mellitus,hypercoagulable state,hypoproteinemia,hypotension after dialysis and incidence in the embolization group were significantly higher than those in the normal group (P<0.05).The blood flow in the fistula was lower than that in the normal group (P<0.05).The compression time,incidence of hematoma compression after dialysis were higher than those in the normal group (P<0.05);factors such as age,hypercoagulable state,hematoma formation,post-dialysis compression time and other factors were positively correlated with fistula embolization in MHD patients (P<0.05);the blood flow during dialysis and hypotension after dialysis were negatively correlated with fistula embolization (P<0.01).Conclusion Risk factors such as age,complicated diabetes mellitus,hypercoagulable state,low blood flow during dialysis,prolonged fistula compression,hematoma compression are important reasons leading to fistula embolization in MHD patients. 2017 Vol. 24 (24): 33-35 [Abstract] ( 239 ) HTML (1 KB)  PDF (592 KB)  ( 115 ) 36 Experience of the treatment for 34 patients of caecal diverticulitis FAN Feng, KANG Tao, LU Yao-liang Objective To summarize the diagnosis and treatment experience of cecal diverticulitis.Methods Retrospective analysis of the clinical data of 34 cases of cecal diverticulitis admitted in the Taicang Hospital of Suzhou University from July 2011 to February 2017 was conducted.All patients showed acute right lower quadrant pain.23 cases of cecal diverticulitis diagnosed by abdominal CT before surgery,misdiagnosed as acute appendicitis in 10 cases,misdiagnosed as appendix abscess in 1 case.19 cases of appendectomy,1 case of ileocectomy,1 case of right colon resection,and 13 cases of conservative treatment of internal medicine.Postoperative observation of the recovery of patients and the incidence of complications.Results All patients were cured and discharged. Three cases (14.3%) were postoperative incision infection.After the dressing,the anastomotic fistula and intestinal fistula occurred.There was no perioperative death.Conservative treatment of 13 patients discharged from abdominal pain after discharge in 9 cases (69.2%),by anti-infective treatment of abdominal pain relief discharged.All cases were followed up regularly,followed up for 1-60 months,the effect of sustained, safe and feasible.Conclusion The rate of misdiagnosis of cecal diverticulitis is high,and conventional CT can significantly improve the accuracy of diagnosis.The conservative treatment of low success rate,high recurrence rate,the proposed active surgical treatment.According to the diverticular inflammation,with or without perforation,the number of diverticulum and other specific circumstances reasonable choice of surgical methods. 2017 Vol. 24 (24): 36-39 [Abstract] ( 341 ) HTML (1 KB)  PDF (705 KB)  ( 188 ) 39 Treatment effect of conformal intensity-modulated radiation therapy and oral Capecitabine for patients with stage Ⅱ and Ⅲ rectal cancer in postoperative nursing LI Sui-hua, LUO Jin-xian Objective To study and analyze the treatment effects of conformal intensity-modulated radiation therapy and oral Capecitabine for postoperative care of patients with stage Ⅱ and Ⅲ rectal cancer.Methods 86 cases of patients with stage Ⅱ and Ⅲ of rectal cancer and who received the treatment in our hospital from February 2013 to March 2015 were selected,and the patients were randomly divided into study group and control group,with 43 cases in each group.All the selected patients were implemented the routine surgery treatment,and the study group were implemented conformal intensity-modulated radiotherapy combined with Capecitabine,while the control group were only treated with conformal intensity-modulated radiation therapy.Then,the clinical effect of two groups was evaluated and analyzed.Results The treatment efficiency in the study group was 83.72%,which was significantly higher than that in the control group of 62.79%,with statistical significance (P<0.01);the disease-free survival rate, overall survival rate and local recurrence rate after the operation for 2 years in the study group were significantly better than those in the control group, with statistical significance (P<0.05).And the incidence of adverse reactions in the study group was 44.19%,which was significantly lower than that in the control group of 65.12%, with statistical significance (P<0.01).Conclusion The treatment effects of conformal intensity-modulated radiotherapy combined with Capecitabine oral administration for patients with stage Ⅱ and Ⅲ rectal cancer,which it has significant clinical effect. 2017 Vol. 24 (24): 39-41 [Abstract] ( 226 ) HTML (1 KB)  PDF (377 KB)  ( 105 ) 42 Comparison of clinical effects of two different nutritional modes on gastrointestinal function in patients with esophageal carcinoma GAO Ke-feng, YANG Ning, LI Xing Objective To compare and analyze the effect of two different nutritional modes on gastrointestinal function in patients with esophageal carcinoma.Methods Retrospective analysis of the clinical data of 126 patients with esophageal cancer who underwent surgical resection in our hospital from June 2016 to January 2017.The patients were divided into mixed nutrition group (EN+PN group) and parenteral nutrition group (PN group) according to the different postoperative nutrition modes of patients,63 cases in each group.The blood was taken at the the morning of preoperative 1 day,third days and eight days after operation for biochemical detection,and the weight loss was calculated.The anal exhaust time,defecation time,postoperative hospital stay,gastrointestinal symptoms and complications were observed after operation.Results The serum albumin,prealbumin and hemoglobin in the two groups were compared with preoperative 1 day,and the differences were not statistically significant (P>0.05).The serum albumin,prealbumin and hemoglobin were significantly reduced in the two groups on the third days and eight days after operation compared with preoperative 1 day,and the differences were statistically significant (P<0.05).While the serum albumin,prealbumin and hemoglobin were significantly higher in the two groups on the eight days after operation compared with the third day after operation,and the differences were statistically significant (P<0.05).On the eighth day after operation,the levels of albumin and hemoglobin in EN+PN group were significantly higher than that of PN group,and the differences were statistically significant(P<0.05).After surgery,the anal exhaust time,defecation time and hospital time of the EN+PN group were significantly shorter than the PN group,and the weight loss was significantly lower than the PN group,the differences were statistically significant (P<0.05). The incidence of digestive tract symptoms and postoperative complications of EN+PN group were significantly lower than that of PN group,and the differences were statistically significant (P<0.05).Conclusion Early enteral parenteral nutrition is beneficial to the recovery of intestinal function as soon as possible after the operation of esophageal carcinoma,and it can shorten the time of hospitalization and less adverse reactions.It is worthy of popularization and application. 2017 Vol. 24 (24): 42-45 [Abstract] ( 231 ) HTML (1 KB)  PDF (382 KB)  ( 119 ) 45 Clinical observation of 64-slice spiral CT in a low-dose scanning and target scanning in the diagnosis of early lung cancer in high risk population LI Wei Objective To compare the advantages and disadvantages of low-dose 64-slice spiral CT and target scanning,and traditional DR chest radiography on screening early lung cancer population,and evaluate the application value of low-dose 64-slice spiral CT scanning with target scanning.Methods From January 2015 to March 2016,362 people with high risk of lung cancer were screened after physical examinations in our physical examination department were selected.All participants were provided with traditional chest radiography and low-dose 64-slice spiral CT scanning with target scanning.Two physicians were invited for outcome observation and diagnosis in double-blind.The results by the two inspection Methods were recorded and comparatively analyzed.Results In traditional DR chest radiography.25 people in high risk of lung cancer group were detected with pulmonary nodules,and the detection rate was 6.91%.In CT,58 participants were detected accounting for 16.02%.The detection rate in CT group was much higher than that in the traditional DR chest radiography (P<0.05).In traditional DR chest radiography,2 people were finally diagnosed as lung cancer,and the detection rate was 0.55%,while in CT scanning with target scanning,9 ones were detected with lung cancer accounting for 2.49%.The detection rate in the latter was higher (P<0.05).Conclusion The detection rate of early lung cancer by 64-slice spiral CT in a low-dose scanning and target scanning is remarkably higher than that by traditional DR chest radiography.Therefore,clinical physicians should attach great importance to 64-slice spiral CT in a low-dose scanning and target scanning,not only focus on the examination results by traditional DR chest radiography. 2017 Vol. 24 (24): 45-47 [Abstract] ( 254 ) HTML (1 KB)  PDF (498 KB)  ( 92 ) 48 Comparative analysis of the diagnostic effects on thyroid tumors by color Doppler ultrasonography or ultrasonic elastography ZHAO Hai-yan Objective To explore the diagnostic effects of color Doppler ultrasonography or ultrasonic elastography on thyroid tumors.Methods From January 2015 to March 2016,170 patients in the department of thyroid of our hospital were selected as the observation objects.They were randomly divided into the experimental group and the control group,85 cases in each group.In the control group,color Doppler ultrasonography was used,while in the experimental group,ultrasonic elastography was adopted.The ultrasonographic findings in the two groups were comparatively analyzed with those by pathological results in later.Results The pathological diagnosis in the experimental group was nodular goiter in 22 cases,follicular thyroid cancer in 8 cases,medullary carcinoma in 6 cases,papillary adenocarcinoma in 17 cases,and thyroid adenoma in 32 cases.The number of nodular goiter,follicular thyroid cancer,medullary carcinoma,papillary adenocarcinoma,and thyroid adenoma was 22,10,8,14,31 cases in the control group accordingly.The diagnostic accordance rate of ultrasound was 97.65% in the experimental group,which was much higher than that in the control group accounting for 71.76%,with statistical difference (P<0.05).In the experimental group,the specificity and sensitivity of ultrasound diagnosis were 91.25% and 93.78%,which was much higher than that in the control group accounting for 69.81% and 72.73%,respectively,which were displayed statistical differences (P<0.05).Conclusion The accuracy of ultrasonic elastography is higher than that of color Doppler ultrasonography in the diagnosis of patients with thyroid tumors. 2017 Vol. 24 (24): 48-50 [Abstract] ( 266 ) HTML (1 KB)  PDF (527 KB)  ( 126 ) 51 Application value analysis of susceptibility-weighted imaging in the diagnosis of cerebral microbleeds CHEN Yong-qian Objective To explore the application value of susceptibility-weighted imaging (SWI) in the diagnosis of cerebral microbleeds (CMBs).Methods 30 CMBs patients admitted in our hospital from February 2016 to January 2017 were selected as the research objects.They were provided with SWI and regular sequence scannings (T1WI,FLAIR,and T2WI),and the scanning outcomes were compared.Results The detection rate of CMBs by SWI was 96.67%,which was higher than that by T1WI,FLAIR,and T2WI (10.00%,56.67% and 16.67%),with statistical differences (P<0.05).The low signal rate of SWI in CMBs was higher than that by regular sequences of T1WI,FLAIR,and T2WI,with significant difference (P<0.05).Conclusion Application value of SWI in the diagnosis of CMBs is remarkable,and provides a strong evidence for determining the therapeutic regimen in clinic in order to promote the balance of cerebral blood supply as well as body recovery. 2017 Vol. 24 (24): 51-53 [Abstract] ( 237 ) HTML (1 KB)  PDF (501 KB)  ( 86 ) 54 Application value of fine needle aspiration cytology examination in the diagnosis of thyroid nodules CHEN Ying-yin, LIU Yu Objective To explore the accuracy of fine needle aspiration cytology in the diagnosis of thyroid nodules.Methods The clinical data of 86 patients with thyroid nodules from June 2014 to September 2016 in our hospital were analyzed retrospectively.The patients were carried out fine needle aspiration cytology examination firstly and then pathological examination were carried out among surgical excision of diseased tissue.The pathological examination results were taken as the gold standard.Disease detection rate was observed by fine needle aspiration cytology and the sensitivity and specificity in the diagnosis of thyroid nodule by cytology examination were analyzed.Results The inspection results of histopathological examination were taken as standard.The specificity,the accuracy rate and the sensitivity rate of fine needle aspiration in testing the disease was 89.8%,88.4% and 88.9% respectively.The detection rate of the disease that the relevance ratio of goiter,carcinoma spongiosum and papillocarcinoma were 98.0%,100.0% and 88.5% respectively by fine needle aspiration examination but the relevance ratio of follicular adenoma was only 25.0%.Conclusion Other than the lower relevance ratio of follicular lesion,the relevance ratio is high by the adoption of fine needle aspiration cytologic examination and diagnosis for patients with other types of thyroid nodule so that it′s of higher diagnostic value. 2017 Vol. 24 (24): 54-56 [Abstract] ( 207 ) HTML (1 KB)  PDF (499 KB)  ( 104 ) 57 Value of clinical application of radiographic technique in the diagnosis of tracheal and bronchial foreign bodies in children WEN Wei-chun Objective To observe and analyze the value of clinical application of radiographic imaging technique in the diagnosis of tracheal and bronchial foreign bodies in children.Methods Altogether 160 children with tracheal and bronchial foreign bodies who were treated in our hospital from July 2012 to July 2016 were selected as the observation objects of this study and divided into the control group and the observation groups according to the difference of radiographic imaging technique,80 cases in each group.The control group was given general X-ray examination,and the observation group was scanned by spiral CT.The detection rate of foreign body in trachea and bronchus and the result of foreign body sign were compared between the two groups.Results The tracheal and bronchial foreign body detection rate of the observation group was 100.00%,which was higher than that of the control group (82.50%),with significant difference (P<0.05).The detection rate of bronchial obstruction,mediastinal position changes,pneumonia,emphysema and pulmonary atelectasis of the observation group was higher than that of the control group,with significant difference (P<0.05).Conclusion Both spiral CT scanning and conventional X-ray examination show good effect in the clinical diagnosis of tracheal and bronchial foreign body in children,however,in contrast with the conventional X-ray examination,spiral CT scanning detection has higher detection rate of pediatric tracheal and bronchial foreign body and more accurate determination in examination of foreign body signs,including the size,morphology and location of foreign objects,which is worthy of promotion. 2017 Vol. 24 (24): 57-59 [Abstract] ( 219 ) HTML (1 KB)  PDF (500 KB)  ( 71 ) 60 Application value of 1.5T magnetic resonance DWI and ADC in differential diagnosis of hemangioma and nodular hepatic carcinoma ZHOU Li-jin Objective To explore the feasibility of 1.5T magnetic resonance diffusion weighted imaging (DWI) and apparent diffusion coefficient(ADC) differential diagnosis of hepatichemangioma and nodular hepatic carcinoma.Methods From March 2014 to December 2016,54 patients with solid nodular lesions treated in our hospital were selected as research objects.All participants were tested by pathologic examinations.Among them,31 patients were with single nodular hepatocellular carcinoma,and the rest were diagnosed as hepatic hemangioma.All patients were performed with 1.5T magnetic resonance DWI scanning.The DWI and ADC images were obtained by the related software.ADC values were measured and signal intensity of the DWI in the two groups was compared as well as the ADC values.Results The lesions in the nodular hepatocellular carcinoma patients,the significant high-signals were predominant in DWI accounting for 90.32%.The lesions showed a slight signal intensity in DWI in patients with hepatic hemangioma accounting for 70.83%.There was statistical difference in the distribution of DWI signal intensity in the two groups(P<0.05).After comparing with nodular hepatic carcinomapatients,the ADC value in hepatic hemangioma group was much higher and displayed statistical difference (P<0.05).Conclusion There are great difference in the characteristics of DWI image signals and ADC values in patients with hepatic hemangioma and nodular hepatocellular carcinoma.1.5T magnetic resonance DWI and ADC can provide important reference for the differential diagnosis,which are worthy of promotion. 2017 Vol. 24 (24): 60-62 [Abstract] ( 280 ) HTML (1 KB)  PDF (500 KB)  ( 183 ) 63 Effect of combination of application of Azithromycin and Cefuroxime in the treatment of pregnancy complicated with Mycoplasma and Chlamydia infections HUANG Guan Objective To study the influence of application of combination of Azithromycin and Cefuroxime on the curative effect and outcome of pregnancy complicated with Mycoplasma and Chlamydia infections.Methods Altogether 200 patients with positive Mycoplasma and Chlamydia who were treated in our hospital from October 2015 to December 2016 were selected,they were randomly divided into control group (n=100) and treatment group (n=100).Patients in control group were only treated with Azithromycin (intravenous injection,oral administration);patients in treatment group were treated with combination of Cefuroxime and Azithromycin on the basis of control group (Intravenous injection,oral administration).The therapeutic effect of the two groups was compared.Results The effective rate of treatment group was 100%,higher than that of control group (86%,P<0.05);the incidence of adverse reactions of treatment group and control group was 10% and 12%,without statistically significant difference between the two groups (P>0.05).Among patients in treatment group,there were 5 cases of premature births,5 cases of premature rupture of membranes and 2 cases of abortions;among patients in control group,there were 11 cases of premature births,11 cases of premature rupture of membranes and 7 cases of abortions.The difference of pregnancy outcomes between the two groups was statistically significant (P<0.05).Conclusion Application of combination of Azithromycin and Cefuroxime in the treatment of pregnancy complicated with Mycoplasma and Chlamydia infections achieves good effect and can reduce the incidence of adverse reactions,which improves the outcome of pregnancy. 2017 Vol. 24 (24): 63-65 [Abstract] ( 250 ) HTML (1 KB)  PDF (503 KB)  ( 189 ) 66 Clinical effect of Diltiazem combined with Digoxin in the treatment of rheumatic heart disease complicated with rapid atrial fibrillation SUN Liang-zhen, FANG Zhen Objective To observe the clinical effect of Diltiazem combined with Digoxin in the treatment of rheumatic heart disease with rapid atrial fibrillation.Methods Forty patients with rheumatic heart disease and rapid atrial fibrillation admitted into our hospital from January 15th,2016 to March 12th,2017 were selected in this study.They were evenly divided into two groups in random,observation group was treated by Diltiazem combined with Digoxin,and control group was only treated by Digoxin.The total clinical effective rate,quality of life,incidence of adverse reactions,and improvement of cardiac function were observed in the two groups.Results The total clinical effective rate was 95.00% in the observation group,much higher than that in the control group accounting for 60.00% (P<0.05).In the observation group,the scores of quality of life including physiological function,social function,psychological function,and material life were (91.44±6.33),(90.26±6.25),(88.43±5.45) points,and (90.35±6.30) points respectively,was higher than that in the control group [(72.45±4.25),(70.15±4.20),(71.21±4.22),(75.34±4.30) points] (P<0.05).The incidence of adverse reactions in the observation group was 5.00%,lower than that in the control group accounting for 35.00% (P<0.05).The improvement of cardiac function in the observation group was 8 cases in grade Ⅰ and 12 cases in grade Ⅱ,which was superior to those in the control group,5 cases in grade Ⅰ and 15 cases in grade Ⅱ(P<0.05).Conclusion Diltiazem combined with Digoxin in the treatment of rheumatic heart disease complicated with rapid atrial fibrillation obtains a remarkable clinical effect,not only ensures the therapeutic effect,but also reduces the incidence of adverse reactions,which has a value for clinical promotion. 2017 Vol. 24 (24): 66-68 [Abstract] ( 236 ) HTML (1 KB)  PDF (493 KB)  ( 89 ) 69 Efficacy of Bifid-triple viable Capsules for severe acute pancreatitis and its effect on TNF-α and SOD levels CHEN Xiang-sheng, XIAO Qing-hua, LIU Su-hua Objective To explore the efficacy of Bifid-triple viable Capsules (Bifico) for severe acute pancreatitis (SPA) and its effects on tumor necrosis factor-α (TNF-α) and superoxide dismutase (SOD) levels.Methods Eighty-two patients with SPA admitted to our hospital from December 2014 to February 2017 were included in the study,and were assigned by random number table,the control group including 40 patients were received conventional care,the observation group including 42 patients were received conventional care combined with Bifico introduced on the day of admission,both for 7 days.The two groups were compared for clinical efficacy.Results Treatment resulted in decreases in TNF-α and Amy and increases in SOD in both groups,which were more significant in the observation group (P<0.05);the time to first flatus,time to first defecation and time to relief of abdominal pain were shorter in the observation group (P<0.05);the overall response was higher in the observation group (92.86%) than that in the control group (72.50%) (P<0.05).Conclusion Bifico provides significant efficacy for the treatment of SPA,as it resulted in better improvement in the inflammatory reactions and better recovery of the gastrointestinal function,supporting its further application. 2017 Vol. 24 (24): 69-71 [Abstract] ( 242 ) HTML (1 KB)  PDF (495 KB)  ( 118 ) 72 Effect of Donepezil in the treatment of senile dementia ZENG Yan, LIAO Jia-long, XIE Chun-hui Objective To evaluate the effect of Donepezil in the treatment of senile dementia.Methods Altogether 81 cases of senile dementia patients who were treated in our hospital from February 2015 to July 2016 were selected as study objects,and were randomly divided into two groups according to the comprehensive sequential method.The control group (n=40) was treated with conventional treatment,while the observation group (n=41) was given Donepezil hydrochloride treatment.The treatment effect of two groups was compared.Results Before treatment,MMSE scores and ADL scores were compared in two groups,the differences were not statistically significant (P>0.05).The total effective rate of observation group was 95.1%,which was significantly higher than that of control group (77.5%),and the difference was statistically significant (P<0.05).Two groups of adverse reactions were compared,and the difference was not statistically significant (P>0.05),the symptoms were mild and gradually relieved after symptomatic intervention.Conclusion Donepezil is effective in the treatment of senile dementia and can effectively improve patients′ mental status and intelligence level with good prognosis.which is worthy of clinical promotion. 2017 Vol. 24 (24): 72-74 [Abstract] ( 235 ) HTML (1 KB)  PDF (493 KB)  ( 104 ) 75 Comparison of efficacy and safety of Paliperidone Extended-Release Tablets and Olanzapine Tablets in the treatment of schizophrenia in children and adolescents LI Duo-cong, CHEN Hai-feng Objective To investigate the efficacy and safety of Paliperidone Extended-Release Tablets and Olanzapine Tablets in the treatment of schizophrenia in children and adolescents.Methods A total of 100 patients with schizophrenia who were admitted to our hospital from April 2013 to April 2016 were selected as subjects,and randomly divided into the Paliperidone Extended-Release Tablets group (group P,n=50) and Olanzapine Tablets group (group A,n=48).Both groups were treated for 12 weeks.PANSS scores were compared between the two groups before treatment and 1,2,4,6,8,10 and 12 weeks after treatment.The incidence of adverse reactions were also compared between the two groups.Results The patients in the group P was effective earlier than that in group A,and the difference was statistically significant (P<0.05).When medication was extended to 12 weeks after treatment,the efficacy of the two groups was compared,and difference was not statistically significant (P>0.05).The incidence of narcolepsy,abnormal liver function,abnormal blood lipid and weight gain were lower in group P than those in group A,the incidence of akathisia was higher than group A,and the differences were statistically significant (P<0.05).Conclusion Paliperidone Extended-Release Tablets and Olanzapine Tablets has similar efficacy in the treatment of schizophrenia in children and adolescents,but Paliperidone Extended-Release Tablets has less side effects than Olanzapine Tablets,and it works faster. 2017 Vol. 24 (24): 75-77 [Abstract] ( 268 ) HTML (1 KB)  PDF (499 KB)  ( 252 ) 78 Determination of related substances in Rivaroxaban by HPLC HUANG Yan, CHEN Xue-yun, YANG Xue-feng, LIU Xia Objective To establish a method to determine the related substance in Rivaroxaban.Methods HPLC method was used,column was Diamonsil C8 (250 mm×4.6 mm,5 μm),the mobile phase A was treated with 5 mmol/L ammonium acetate solution (containing 0.3% 25% tetramethyl ammonium hydroxide solution,adjusted to pH 4.8 with glacial acetic acid)-acetonitrile (80∶20),the mobile phase B was treated with 5 mmol/L ammonium acetate solution (containing 0.3% 25% tetramethyl ammonium hydroxide solution,pH was adjusted to 4.8 with glacial acetic acid)-acetonitrile (10:90),which was used as gradient elution The detection wavelength was 250 nm.Results The resolution of rivaroxaban and its related substance was above 2.0,detection limit was 0.2-0.5 ng,quantification limit was 1.0-2.0 ng.Conclusion The method is suitable for the determination of related substance in Rivaroxaban. 2017 Vol. 24 (24): 78-81 [Abstract] ( 288 ) HTML (1 KB)  PDF (687 KB)  ( 381 ) 82 Optimization of dry granulating technique of Isatidis Radix granule through response surface methodology DU Zhong-mei Objective To determine the optimum granulating process conditions of Radix Isatidis granules,and to investigate the influence of auxiliary material,feeding speed,rolling speed and roller pressure on dry granulation technique.Methods Taking the rolling wheel speed and pressure and feeding speed as the independent variable,the shaping rate and dissolubility as the dependent variable,the parameters for Isatidis Radix dry granulation were optimized and validated through response surface methodology.Results The results of the statistical model showed that rolling wheel rate and feeding rate were the key variables which had significant impact on the properties of Isatidis Radix granules.The optimum parameters were identified as follows,feeding rate at 50 r/min (X1),rolling wheel rate (X2) at 8 r/min and pressure (X3) at 15 MPa.The three scaled-up batches of validated experiments showed that the granules manifested higher shaping rate at one time and lower dissolution time (80.88% and 14.3 min,respectively).Based on the data obtained from predicted values and measured values,the model showed good prediction ability and accuracy.Conclusion The approach of response surface methodology applies to investigate and optimize dry granulation of Isatidis Radix is feasible and reasonable.The model is robust and high predictble to provide reliable basis for production. 2017 Vol. 24 (24): 82-84 [Abstract] ( 198 ) HTML (1 KB)  PDF (587 KB)  ( 321 ) 85 Research on ultrasonic extraction process of total Flavonoids from the roots of Ephedra sinica Stapf YU Qi Objective To study the extraction process of the total Flavonoids from roots of Ephedra sinica Stapf.Methods The content of total Flavonoids in root of Ephedra sinica Stapf was determined by UV visible spectrophotometry.The influence of ethanol fraction,solid-liquid ratio,extraction duration and extraction times on the extraction rate of total flavonoids were investigated,and the orthogonal design was used to optimize the extraction process.Results The detection wavelength was 500 nm.The RSD of precision and reproducibility tests were 1.26% and 1.07%,the sample was stable within 10 h,and the average recovery rate was 98.80%.The optimum conditions for extracting the total flavonoids were as follow:material-liquid ratio was 1∶12,alcohol concentration was 75%,extraction times was twice and extraction duration was 30 min.Conclusion The extraction process is simple,stable and feasible,and suitable for the industrial production. 2017 Vol. 24 (24): 85-88 [Abstract] ( 215 ) HTML (1 KB)  PDF (643 KB)  ( 112 ) 89 Clinical effect analysis of Chinese herbal formula Shenfu Huangpu Decoction in the treatment of stomachache of spleen and stomach deficiency cold HUANG Wen-qin Objective To explore the clinical effect of traditional Chinese herbal formula Shenfu Huangpu Decoction in the treatment of stomachache of spleen and stomach deficiency cold.Methods From February 2015 to February 2017,94 patients with stomachache stomachache of spleen and stomach deficiency cold treated in our hospital were selected and divided into experimental group and control group in random and there were 47 cases in each group.In the control group,patients were treated with conventional Western medicine,while in the experimental group,on the basis of the control group,Shenfu Huangpu Decoction was added.The clinical effect between the two groups was compared.Results The total effective rate in the experimental group was 93.62%,which was significantly higher than that in the control group (78.72%),which was displayed a statistical difference (P<0.05).Before treatment,the symptomatic score of traditional Chinese medicine (TCM) and visual analogue scale (VAS) score between the two groups were not greatly different after comparison (P>0.05).After therapy,the improvement of TCM symptomatic score and VAS score in the experimental group was significantly better than that in the control group,with statistical significance (P<0.05).Conclusion In the treatment of stomachache due to the spleen and stomach deficiency cold,Chinese herbal formula Shenfu Huangpu Decoction as a combined therapy can obtain a more definite effect in comparison with that by Western medicine alone.It remarkably improves the patients′ symptoms of stomachache and its safety is high,and it is worthy of further clinical application in clinic. 2017 Vol. 24 (24): 89-91 [Abstract] ( 217 ) HTML (1 KB)  PDF (440 KB)  ( 253 ) 92 Clinical effect of TCM syndrome differentiation treating chronic gastritis LU Xiao-qing Objective To explore the clinical effect of TCM syndrome differentiation treating chronic gastritis.Methods 100 patients with chronic gastritis treated in our hospital from March,19 2016 to March 19,2017 were selected and they were divided into control group (n=50) and observation group (n=50).The control group was treated with Teprenone Capsules and the observation group was treated with TCM syndrome differentiation therapy.Clinical effect between the two groups was compared.Results The total effective rate (98.00%) in the observation group was higher than that in the control group (66.00%),the score of the intestinal metaplasia score [(0.22±0.13) points],dysplasia score [(1.51±0.37) points],glandular atrophy score [(1.65±0.74) points],and the incidence rate of complications (2.00%) were higher than those of control group [(1.71±0.85) points,(2.41±1.63) points,(2.52±1.34) points,22.00%] (P<0.05).Conclusion TCM syndrome differentiation treating chronic gastritis has a significant effect and high safety. 2017 Vol. 24 (24): 92-94 [Abstract] ( 240 ) HTML (1 KB)  PDF (443 KB)  ( 137 ) 95 Influence of Huayu Jiegu Powder on the healing of upper limb closed fracture and analysis of adverse reaction LIU Dong-sheng, HU Xiao-yi, ZHANG Ying-ying, LIU Zhong-yue, HUANG Zeng-rong, YUAN Chang Objective To investigate the influence of Huayu Tonggu Powder on the healing of upper limb closed fracture and the adverse reaction.Methods A total of 120 patients with upper limb closed fracture treated in department of Orthopedics and Traumatology from January 2016 to June 2017 were collected.The patients were divided into control group (n=60) and observation group (n=60) using the random number table method.The patients in control group were treated by conventional manual reduction splint while the patients in observation group treated by Huayu Jiegu Powder for external application based on the treatment of the control group.Treatment cycles were 45 days.Clinical curative effect in the two groups were observed,and fracture healing time,limb pain,swelling degree score,X-ray examination results after the 1st,3rd,5th,7th,9th week operation and adverse reactions of patients in the two groups were observed.Results After 45 days of treatment,the total effective rate was 95.0% in the observation group,which was significantly higher than that in the control group (85.0%) (P<0.05).The X-ray score of patients in observation group were obviously higher than those of control group after the 5th,7th,9th week operation (P<0.05).The healing time of fracture in observation group was significantly shorter than that of control group (P<0.05).During the course of treatment,9 cases of adverse reactions occurred in observation group,its main manifestation was skin itching,after treatment,symptoms disappeared,and it did not produce adverse effects on the results.Conclusion The clinical treatment of upper limb closed fracture can shorten the healing time of fracture and improve the X-ray score,and reduce the adverse reaction,which is worthy of clinical promotion and application. 2017 Vol. 24 (24): 95-97 [Abstract] ( 259 ) HTML (1 KB)  PDF (475 KB)  ( 154 ) 98 Analysis of metabolic related indexes and MTHFR gene polymorphism in patients with H-type hypertension LIU Ling-ling, TANG Zhi, XIAO Lin, SU Qi-wen, CHEN Wen-rong Objective To analyze the polymorphism of MTHFR gene in patients with hypertension,and to explore the relationship between H-type hypertension and metabolic biochemical indexes such as homocysteine (Hcy).Methods 100 patients with H-type hypertension and 100 patients with general hypertension treated in our hospital from July 2013 to June 2016 were selected as study subjects.Plasma homocysteine (Hcy) and blood lipids,blood glucose and other biochemical indicators were detected in two groups,and the polymorphism of MTHFR gene was compared.Results Hcy,uric acid (UA),creatinine (Cr) level in the H-type hypertension group were significantly higher than those in the general hypertension group (t=14.989,6.672,4.832,P<0.05).The frequency distribution of MTHFR 677C/T genotype frequency of the H-type hypertension group was mainly T allele,and the frequency distribution of C allele was dominant in the general hypertension group (P<0.05).Conclusion The level of Hcy,UA and Cr are closely related to the occurrence of H-type hypertension.Homozygous mutant TT genotype of MTHFR gene 677C/T may be an important genetic factor of H-type hypertension. 2017 Vol. 24 (24): 98-101 [Abstract] ( 287 ) HTML (1 KB)  PDF (668 KB)  ( 141 ) 101 Clinical evaluation on pediatric acute renal injury and early biomarkers LIU Hua, HE Xiao-jie, DING Qing-xiong, LIANG Wan-xia, LI Guo-jun, FAN Juan Obiective To analyze the clinical features of pediatric acute kidney injury and to investigate the diagnostic value of biomarkers for pediatric AKI.Methods From June 2016 to March 2017,a total of 60 patients who were hospitalized in the department of pediatric in our hospital and the second xiangya hospital of central south university were selected as research objects.They were assigned to AKI group (30 cases) and non-AKI group (30 cases) according to the definition by the AKIN criteria.Also 24 healthy children of the same age were recruited as the control group.The clinical characteristics and influencing factors of AKI children were analyzed,and the biomarkers of different groups of children were observed and the diagnostic value of different biomarkers for AKI was compared.Results The common causes of AKI were sepsis,drug intoxication,severe allergic purpura and snakebite.Height and weight had a higher correlation with AKI (P<0.05).At 2 hours after hospitalization,except SCr,the levels of urine KIM-1,NGAL,L-FABP,serum CysC,and serum NGAL were significantly higher in AKI group than those in non-AKI group,and the differences were statistically significant（P<0.01).At 48 hours after hospitalization,the levels of SCr were significantly higher in AKI group than those in non-AKI group,and the differences were statistically significant（P<0.01).Although the levels of other biomarkers in AKI group declined,they were still significantly higher than those in non-AKI group,and the differences were statistically significant（P<0.01).At 2 hours after hospitalization,the value for the AUC was determined for urine KIM-1,NGAL,L-FABP,serum CysC,NGAL and SCr was 0.912,0.922,0.909,0.906,0.943 and 0.533 respectively.At 48 hours after hospitalization,the value for the AUC was determined for urine KIM-1,NGAL,L-FABP,serum CysC,NGAL and SCr was 0.887,0.904,0.858,0.818,0.889 and 0.942 respectively.Conclusion s AKI is associated with the disease severity.Height and weight may be the influence factors of pediatric AKI in renal pathologic conditions.The serum level of NGAL may have good reference value for early clinical diagnosis of AKI,SCr is still an impor tant predictor of AKI. 2017 Vol. 24 (24): 101-105 [Abstract] ( 231 ) HTML (1 KB)  PDF (542 KB)  ( 108 ) 106 Clinical value of procalcitonin combined with C-reactive protein predicting acute exacerbation of chronic obstructive pulmonary disease HUANG Chun-yan, ZHANG Cai-xia Objective To assess the clinical value of serum procalcitonin (PCT) in combination with CRP in prediction acute exacerbation of chronic obstructive pulmonary disease (AECOPD).Methods 120 patients treated in Department of Respiratory Medicine of the Third People′s Hospital of Hubei Province from January to December 2016 were selected and they were divided into AECOPD group (n=60) and stable period group (n=60).The value of PCT,CRP and WBC count was measured in two groups and the data between the two groups was compared.At the same time,the sensitivity and specificity predicting AECOPD of various index were observed,and the correlation of PCT and CRP,WBC count were analyzed.Results PCT and CRP in AECOPD group were significantly higher than those in stable period,there was a statistical significance (P<0.05).The WBC count in AECOPD group was higher than that in stable period,but there was no statistical difference (P>0.05).The sensitivity of PCT,CRP,WBC count judging AECOPD was 87%,73% and 62% respectively,the specificity was 73%, 68% and 60% respectively.The sensitivity and specificity of PCT combined with CRP increased to 88% and 75% respectively.PCT and CRP,WBC showed a positive correlation (r=0.521,0.308,P<0.05).Conclusion Serum PCT has high sensitivity and specificity,dynamic combined detection of PCT and CRP can be used as an inflammatory indicator predicting AECOPD in early stage. 2017 Vol. 24 (24): 106-108 [Abstract] ( 219 ) HTML (1 KB)  PDF (515 KB)  ( 93 ) 109 Experimental observation on the influence of Shenmai Injection on blood flow function in patients with chronic pulmonary heart disease YANG Jian, LAN Dan Objective To observe the influence of Shenmai Injection on blood flow function in patients with chronic pulmonary heart disease.Methods 124 patients (volunteers) with chronic pulmonary heart disease treated in department of clinical laboratory of our hospital from January 2014 to November 2015 were randomly divided into control group and experimental group.62 cases of control group were treated with conventional western medicine treatment such as control infection,strong heart,diuretic,smooth wheezing expectorant,low flow oxygen,correct electrolyte and acid-base balance disorder and so on.The experimental group (n=62) was treated with conventional western medicine combined Shen-mai Injection.The course of the treatment were 14 days.Blood flow function indexes (blood rheology,haematocrit and fibrinogen) were determined before and after treatment in two groups.Results After treatment,the whole blood high shear reductive viscosity [(7.86±1.28),(7.71±1.11) mPa·s] whole blood low shear reduction viscosity [(54.96±9.43),(49.00±4.51) mPa·s],plasma viscosity [(1.88±0.28),(1.43±0.18) mPa·s],fibrinogen [(2.50±1.11),(2.05±1.13) g/L] and hematocrit[(0.45±0.09),(0.43±0.04) L/L] in control group and experimental group were improved compared with before treatmenrt (P<0.05).The treatment group showed the improved significantly better than the control group except the whole blood high shear reductive viscosity (P<0.05). Conclusion On the basis of conventional western medicine treatment,Shenmai Injection added treating chronic pulmonary heart disease can obviously improve blood flow function indexes of patients,and it may be has an positive meaning for long term stablely control of patients′ condition and reduce the occurrence of complications. 2017 Vol. 24 (24): 109-111 [Abstract] ( 242 ) HTML (1 KB)  PDF (545 KB)  ( 100 ) 112 The application value of insulin autoantibodies and biochemical indexes in the type diagnosis of diabetes mellitus BAO Cai-li, YU Ying, LIU Wen, YING Xiao-wen, DU Shan-qing, WU Di, GONG Ling, TANG Yuan-yuan Objective To analyze and discuss the clinical application value of detection islet cell antibodies,anti-insulin antibodies and glutamic acid decarboxylase antibodies in the diagnosis of diabetes mellitus.Methods 230 cases of clinical diabetes mellitus patients admitted to our hospital from August 2013 to August 2016 were selected as the study subjects.The indexes of islet cell antibodies,anti-insulin antibodies and glutamic acid decarboxylase antibodies were detected.The T1DM group and T2DM group were divided according to antibody negative/positive classification,the FBG,INS and CP concentrations of two groups were observed.Results The positive rate of islet cell antibodies,anti-insulin antibodies and glutamic acid decarboxylase antibodies of patients in T1DM group was significantly higher than that in T2DM group,and the differences were statistically significant (P<0.05).The INS concentrations of islet cell antibodies,anti-insulin antibodies and glutamic acid decarboxylase antibodies of positive group and negative group were compared,and the differences were statistically significant (P<0.05);the indexes of FBG and CP of islet cell antibodies,anti-insulin antibodies and glutamic acid decarboxylase antibodies of positive group and negative group were compared,and the difference was not statistically significant (P>0.05).Conclusion For diabetes mellitus patients,the detection of insulin autoantibodies have great guiding significance in the early diagnosis,typing and treatment. 2017 Vol. 24 (24): 112-114 [Abstract] ( 256 ) HTML (1 KB)  PDF (557 KB)  ( 155 ) 115 Influence analysis of trace element detection of child care on child care QIU Xiao-bing Objective To analyze the influence analysis of trace element detection of child care on child care.Methods 600 children examined in our hospital from August 2014 to August 2015 were selected as objects and they were randomly divided into experimental group (310 children aged 1-2 years,160 boys and 150 girls) and control group (290 children ager >2-3 years,150 boys and 140 girls) according to their age.Peripheral blood (ring finger) was taken from the all 600 children and the level of trace element were detected by atomic absorption spectrometry and the results were recorded in detail.The level of trace elements were compared between the two groups.Results The incidence of iron deficiency (71.94%) and the incidence of zinc deficiency (79.03%) in the experimental group were significantly higher than those in the control group (50.34%,42.07%) (P<0.05).The iron level [(6.60±0.55) μmol/L] and zinc level [(68.30±7.20) μmol/L] in the experimental group were significantly lower than those in the control group [(7.90±0.20),and (76.05±9.78) μmol/L] (P<0.05).Conclusion The detection of trace elements in children′s health care can help to fully understand the level of trace element in children,and guide to timely supply imbalanced elements according to the scientific test results,which can promote the healthy growth of children. 2017 Vol. 24 (24): 115-117 [Abstract] ( 254 ) HTML (1 KB)  PDF (514 KB)  ( 120 ) 118 The effect of cryoprecipitation dissolution with dry blood soluble machine and water-bath blood soluble machine and the length of dissolution time on the biological activity of coagulation factor in cryoprecipitate YANG Qing-wen, LI Guang-ying, DING Wen Objective To investigate the use of dry and water-bath blood soluble machine for cryoprecipitation dissolution and the effect of length of dissolution time on the biological activity of coagulation factors in cryoprecipitate,in order to provide the basis for better results.Methods Altogether 120 bags of cryoprecipitate (Specification:1.0 U/Bag) with similar blood collection dates (less than 5 days) that were provided by our Central Blood Station of Baoan from February 3rd to February 7th in 2016 were selected and randomly divided into two groups (group 1 and group 2),with 60 bags in each group.group 1 adopted dry blood soluble machine for cryoprecipitation dissolution;while,group 2 adopted water-bath blood soluble machine for cryoprecipitation dissolution.FactorⅧ (FⅧ),von Willebrand factor antigen (vWF-Ag),prothrombin time (PT),thrombin time (TT),activated partial thromboplastin time (APTT) and plasma fibrinogen (Fib) of 120 cryoprecipitate samples that were placed in different blood soluble machines at 37℃ for 10,20 min and 30 min were determined.Results There was no statistically significant difference between group 1 and group 2 in the effects of blood plasma dissolution and all the indexes (P>0.05);however,with the prolonging of dissolution time,prolonged APTT as well as decreased activity of FⅧ and VWF antigen were seen,with statistically significant difference (P<0.05).Conclusion Prolonged blood plasma dissolution time will lead to decreased activity of FⅧ and VWF antigen as well as prolonged APTT,with statistically significant difference.To achieve better efficacy of clinical blood transfusion,the best time for cryoprecipitation dissolution is recommended to be 10 min. 2017 Vol. 24 (24): 118-120 [Abstract] ( 234 ) HTML (1 KB)  PDF (313 KB)  ( 222 ) 121 Analysis of the influence of fire scene simulation and cognitive training on peripheral blood of primary school students GAN Xue, ZHOU Su-zhi, LI Zhi-meng Objective To analyze the influence of practical exercise with or without fire scene simulation and cognitive training on the peripheral blood of primary school students of grade five.Methods Altogether 90 primary school students of grade five in June 2016 were selected from a primary school and divided into three groups according to their gender and age:control group and experiment group (untrained group and training group).venous blood (2 ml) was collected by using EDTA-K2 anticoagulant tube from each primary school student of control group and experiment group who participated in the practical exercise and was analyzed by using mindray BC-5390 automatic blood cell analyzer to acquire the white blood cell (WBC) count,neutrophil percentage,lymphocyte percentage,monocytes percentage,red blood cell (RBC ) count and platelet count.Results ①WBC count,neutrophil percentage,RBC count and platelet count of untrained group were significantly higher than those of control group with statistically significant difference (P<0.05),while the lymphocyte percentage and monocytes percentage of untrained group were significantly lower than those of control group with statistically significant difference (P<0.01).②WBC count,neutrophil percentage,RBC count and platelet count of untrained group were higher than those of training group with statistically significant difference (P<0.05),while the lymphocyte percentage and monocytes percentage of untrained group were significantly lower than those of training group with statistically significant difference (P<0.05).③The neutrophil percentage was negatively correlated with the lymphocyte percentage (r=-0.980,P<0.01).④WBC count,neutrophil percentage,lymphocyte percentage,monocytes percentage,RBC count and platelet count of training group had no statistically significant difference in contrast with control group (P>0.05).Conclusion Practical exercise after fire scene simulation and cognitive training plays an important role in maintaining the stability of peripheral blood indexes for primary school students. 2017 Vol. 24 (24): 121-123 [Abstract] ( 255 ) HTML (1 KB)  PDF (423 KB)  ( 125 ) 124 Comparison of cleaning effect of clean cloth with different materials on high-frequency contact surface of the hospital XIONG Hui-ping, LI Hui-qin, ZHOU Lian-ying, YU Zhong-xia Objective To improve the cleaning effect of high-frequency contact surface in the hospital and reduce the incidence of hospital-related infection.Methods From November to December 2016,60 surfaces including keyboard,door handle,telephone,micro pump,bedside bell and bed bar,etc.from departments of gynaecology and obstetrics,orthopedics,and general surgery were selected as research objects.The surfaces were cleaned by the cloths with three different materials and samples were collected before and after cleaning.Results The bacterial clearance rates of disinfecting wipe,microfiber towel,and cotton towel was 93.9%,92.4% and 65.2% respectively,and the qualified rate meeting the hygienic standard after cleaning was 100%,95% and 30% accordingly,and the cleaning effect of disinfecting wipe and microfiber towel were better than that by cotton towel (P<0.05).The bacterial clearance rate was not displayed statistical difference in disinfecting wipe and microfiber towel (P>0.05).Conclusion Both disinfecting wipe and microfiber towel obtain favorable cleaning effect,but the cost performance of disinfecting wipe is much lower than that of the microfiber towel,so microfiber towel is the best choice. 2017 Vol. 24 (24): 124-126 [Abstract] ( 217 ) HTML (1 KB)  PDF (425 KB)  ( 288 ) 127 Teaching reform practice in large classroom on college--Environment and Health course GAO Kai-ping, YANG Yi, ZHAI Ri-hong, JIAO Ya-bin, ZHAO Zhen-fu Objective To explore the teaching effects of volunteer students-based "Little Teacher Teaching Group" and to enhance the interactions between students and teachers in the classroom.Methods An integrated approach that combined the TBL,PBL,and “Sandwich” teaching was developed and practiced in the course of “Environment and Health” for 370 class 1-4 students from September 2014 to July 2015.The teaching results were collected via questionnaire at two time points:Before the start of the course and at the end of the course.Data were analyzed using SPSS,confirmed the advantages and feasibility of this teaching approach.Results After learning from the new teaching model,the volunteer student group displayed increased awareness of what′s the health and sub-health condition and showed more concern on environmental pollution.In examination on the knowledge about human health and four different sources of pollution including indoor air,outdoor air,water and soil,their correct answer rate was significantly increased after taking the class （P<0.001）.Conclusion The results showed that this new teaching model not only increased the learning enthusiasm of the students in the large class as well as in pre-class preparation,but also significantly improved the students′abilities in analyzing and solving problems,learning new knowledges in related fields,and broadening their view sights. 2017 Vol. 24 (24): 127-130 [Abstract] ( 225 ) HTML (1 KB)  PDF (461 KB)  ( 140 ) 131 Evaluation and analysis of constructing open mode of students′self-management training room WANG Ji-hong, WEI Xiao-ya Objective To explore the effect and evaluation method of the open mode of students′ self-management training room.Methods From September 2014 to March 2016,the nursing students who needed to study in the open training room were selected as the research object.According to the different grades,they were divided into control group (n=108) and observation group (n=152).In the control group,the teacher-led management mode was used,while in the observation group,the student self-management mode was adopted.The questionnaire was filled at the end of the study.The class hour and score of skill performance in the two groups were compared.The opinions on opening training room by these students were investigated and analyzed in the observation group.Results The number of class hours after class in the observation group was much higher than that in the control group (t=2.503,P=0.028).Students in the observation group were satisfied with opening training room (all x>4).The scores of aseptic technique and intravenous infusion in the observation group were both higher than those in the control group.The excellent and good rate in the observation group was also higher in comparison with that in the control group (χ2=4.305,P=0.038),which were displayed statistical differences in nursing performance (all P<0.05).Conclusion The implementation of the students′self-management mode in the training room stimulates their enthusiasm to learn,improve their skills,and promote the improvement of the overall quality of students.Simultaneously,the utilization of training room has been increased. 2017 Vol. 24 (24): 131-134 [Abstract] ( 208 ) HTML (1 KB)  PDF (459 KB)  ( 128 ) 135 The influence of group counseling on health workers′ academic emotions WEI Liang-yun, ZHANG Wei, ZHOU Jun, YUAN Li-ping Objective To explore an effective and feasible interventions to improve the academic emotions of health worker and improve learning outcomes.Methods A total of 30 people were selected from 109 health workers who were trained in our hospital from April to October 2016.They were randomly divided into experimental group and control group,each group of 15 people.The 5-week group counseling was conducted in the experimental group,and the general academic emotions survey was conducted in the experimental group and the control group before and after the intervention.Results After 5 times of group counseling,the positive scores of the health workers in the experimental group were significantly improved,the negative emotional scores decreased significantly,and the difference was statistically significant (P<0.05).After the intervention,the difference between the experimental group and the control group was statistically significant(P<0.05)in the study,relaxation,anger,disappointment,pleasure,hope and interest.Conclusion Group counseling can improve health workers′academic emotions,and the method is effective and feasible. 2017 Vol. 24 (24): 135-137 [Abstract] ( 206 ) HTML (1 KB)  PDF (478 KB)  ( 138 ) 138 A report about acute disseminated encephalomyelitis after injecting men-ingococcus A vaccine and encephalitis vaccine WANG Xiu-qin, YANG Shu-lan, LI Jian-qin One child who was healthy and without contraindications suffered acute disseminated encephalomyelitis after injecting meningococcus a vaccine and encephalitis vaccine at the same time.By identificated method of abnormal reaction about immunization,municipal experts group immediately launched status survey,after analyzing the inoculation situation,the treatment situation,the use of vaccines and syringes,and so on,the suspected preventive inoculation response (AEFI) was diagnosed as an inoculation response finally.And apply compensation for the child from government′s special funds,which provided for abnormal reaction following immunization.The child′s prognosis is not so good owing to delay treatment,so in order to find the AEFI without delay and protect the health of children,inoculational staff should strengthen the active monitor after vaccination in 24 h,parents should pay more attention to children′s health after vaccination in 24 h. 2017 Vol. 24 (24): 138-140 [Abstract] ( 246 ) HTML (1 KB)  PDF (410 KB)  ( 260 ) 141 One case report and literature review of glutaric academia typeⅠ ZHENG Qi-hua To investigate the clinical features,laboratory examination and treatment of glutaric academia typeⅠ,the clinical data of 1 clinically-diagnosed GA1 child were analyzed retrospectively and in combination of literatures in this paper.The child was characterized by psychomotor retardation,extrapyramidal symptoms and head deformity.The test results of blood amino acid was detected by tandem mass spectrometry showed glutaric acid carnitine significantly increased and was accompanied with decreased free carnitine,suggested the existence of GA1;the test results of urinary organic acid was detected by gas chromatography-mass spectrometry showed glutaric acid significantly increased.The child was treated with supplement of Vitamin B2,L-carnitine,Baclofen for muscle tension relief and limitation of protein diet (limited intake of lysine and tryptophan).The symptoms were relieved after treatment.Some clinical manifestations,such as psychomotor retardation,extrapyramidal symptoms and head deformities,may be of guiding effectiveness for the early detection and early diagnosis of GA1.Application of gas chromatography-mass spectrometry and tandem mass spectrometry for screening of genetic metabolic diseases is helpful for the early diagnosis of inherited metabolic diseases.The treatment at the acute stage is mainly focused on symptomatic support and promotion of the excretion of toxic metabolites.The treatment at the chronic stage is mainly focused on the restricted protein diet. 2017 Vol. 24 (24): 141-143 [Abstract] ( 224 ) HTML (1 KB)  PDF (408 KB)  ( 227 ) 144 Clinical observation of oral liquid paraffin oil in improving the success rate of indwelling gastric XIA Qiu-yan, CHEN Zhen-yu, LIU Yan Objective To improve the success rate of catheterization by adjusting the indwelling gastric tube method and oral liquid paraffin oil before catheterization.Methods 140 cases enrolled in our department from October 2015 to May 2016 were selected and randomly divided into the observation group and the control group,with 70 cases in each group.The patients in the observation group were given gastric intubation with modified method,while patients in the control group were given gastric intubation with traditional method.The intubation time,the one-time intubation success rate,comfortableness rate and the adverse reaction rate were comapred between two groups.Results The intubation time in the observation group [(6.12±1.02) min] was shorter than that in the control group [(10.08±1.04) min],the one-time intubation success rate (100.00%) and comfortableness (92.86%) was higher than that in the control group(70.00%,70.00%),the adverse reaction rate (4.28%) was lower than that in the control group (18.57%),and the differences were statistically significant (P<0.05).Conclusion Through the new method of indwelling gastric tube,the oral administration of paraffin oil before leaving the gastric tube greatly improved the success rate of catheterization,Efficient,safe,easy to operate and simple,so as to reduce the pain of patients,shorten the operation time,improve the efficiency and quality of care,nurses and patients with satisfaction,worthy of clinical wide promotion and application. 2017 Vol. 24 (24): 144-146 [Abstract] ( 228 ) HTML (1 KB)  PDF (708 KB)  ( 150 ) 147 Efficacy of standardized nursing on patients with multi-drug resistant bacteria infection CHEN Gen-xiu, DENG Wu-xiu, ZHONG Mei-xing, ZHANG Qiao-ling, CHEN Guan-feng Objective To explore the efficacy of standardized nursing on patients with multi-drug resistant bacteria infection.Methods 120 patients treated in the Department of Pneumology in Gannan Medical College First Affiliated Hospital from January 2011 to December 2014,who were diagnosed with lower respiratory infection with more than twice positive results of sputum culture and treated by bacteria-sensitive antibiotics were selected.78 hospitalized patients (January 2011 to December 2012) meeting the inclusion criteria were divided into the control group,and 42 patients (January 2013 to December 2014) were divided into the observation group as standardized nursing had been conducted since January 2013 among patients with multi-drug resistant bacteria infection in respiratory tract.The implementation effect of two groups were compared.Results The general condition of patients,outcome of patients and sputum culturing results in the observation group were all significantly better than those in the control group,the incidence rate of multi-drug resistant bacteria lower than that in the control group,the satisfaction of patients and hand sanitation execution rate were higher than those in the control group,the number of days of antibiotics application and hospital days were shorter than those the control group,the hospital costs was less than that in the control group,and the differences were statistically significant (P<0.05).Conclusion Standardized nursing management can reduce the number of hospitalized days in patients with multi-drug resistant bacteria infection,increase the negative conversion ratio of sputum culturing,shorten the average days of antibiotic application,reduce the cost of hospitalization,improve the general condition of patients,promote the outcome of patients,improve patients′satisfaction,reduce the incidence of multi-drug resistant bacteria and improve hand sanitation execution rate among medical workers,which is worthy to be promoted. 2017 Vol. 24 (24): 147-150 [Abstract] ( 211 ) HTML (1 KB)  PDF (765 KB)  ( 210 ) 151 Effect of community health management on elderly patients with hypertension BI Xue-zhi Objective To explore the clinical effect of community health management in elderly patients with hypertension.Methods From May 2015 to April 2017,300 elderly patients with hypertension treated in physical examination center,internal medicine clinic and inpatient department in Xinhua Community Health Service Center in Huadu District in Guangzhou were selected and they were divided into the study group and the control group,and there were 150 cases in each group according to the random number method.Patients in control group were given the routine care intervention,while the study group was given community health management on the basis of the control group.The blood pressure,body mass index,fasting blood glucose,triglyceride,cholesterol index,health behavior awareness,healthy lifestyle,anxiety and depression score,SF-36 score,incidence of rehospitalization and the incidence of adverse reactions were compared between the two groups.Results After the intervention,the blood pressure,body mass index,fasting blood glucose,triglyceride and cholesterol index of the study group were significantly improved compared with the control group (P<0.05).The proportion of healthy lifestyles in the study group was significantly higher than that in the control group (P<0.05).The score of anxiety and depression in the study group were significantly lower than those in the control group (P<0.05).The awareness rate of health behavior and SF-36 score in the study group were significantly higher than those in the control group (P<0.05).The incidence of hospital admission and the incidence of adverse reactions were significantly lower in the study group than in the control group (P<0.05).Conclusion Community health management applied in elderly hypertensive patients can improve the anxiety and depression of patients,improve the life quality of patients,control the blood pressure level of patients,reduce the incidence of adverse reactions and hospital readmission,and it is worthy of clinical promotion and application in clinic. 2017 Vol. 24 (24): 151-154 [Abstract] ( 237 ) HTML (1 KB)  PDF (712 KB)  ( 151 ) 154 Influence of nursing intervention on pressure sore of ICU patients HUANG Yu-mei, LU Xu-ying Objective To explore the influence of nursing intervention on the pressure sore of patients in intensive care unit (ICU).Methods 86 patients with high-risk decubitus ulcerstreated with ICU from February 2014 to July 2016 were selected to carry out a control research,who were divided into observation group (n=43) and control group (n=43).The control group was given routine clinical intervention,while the observation group was given nursing intervention.The observation indexes included the incidence of pressure sores,the changes of life quality scores before and after intervention and the degree of nursing satisfaction.SPSS 20.0 version software was used to examine the differences between the two groups.Results There were 2 cases in the observation group and 3 cases in the control group,respectively,because of the death from the study.The incidence of pressure sore in observation group was much lower than that in control group,the difference was statistically significant (P<0.05).Before intervention,there was no significant difference in quality of life scores between the observation group and the control group(P>0.05).After intervention,the scores of the two groups were significantly higher than those before intervention,the difference was statistically significant (P<0.05).After the intervention,the QOL scores in each dimension of the observation group were much higher than that of the control group,the difference was statistically significant (P<0.05).The satisfaction degree between the observation group and the control group was statistically significant (P<0.05).The total satisfaction of the observation group was much higher than that of the control group,the difference was statistically significant (P<0.05).Conclusion In ICU patients with inevitable pressure sores,nursing intervention can not only reduce the incidence of pressure sores,but also improve the quality of life and enhance the satisfaction of patients. 2017 Vol. 24 (24): 154-156 [Abstract] ( 181 ) HTML (1 KB)  PDF (711 KB)  ( 133 ) 157 Nursing cooperation in laparoscopic uterine artery blockage combined with myomectomy WU Xiao-yan Objective To explore the clinical effect of laparoscopic uterine artery blockage combined with myomectomy and nursing care.Methods 66 patients with uterine fibroids treated in our hospital from March 2015 to January 2016 were selected as the subjects and were divided into the observation group and the control group according to the time of admission.The observation group was given laparoscopic uterine artery blockage combined with myomectomy.The control group was given laparoscopic myomectomy.All the patients were treated with nursing care during the perioperative period.The duration of surgery,intraoperative blood loss,length of hospital stay and the incidence of complications were compared between two groups.Results The duration of surgery in the observation group was longer than that in the control group,the intraoperative blood loss was less than that in the control group,the length of hospital stay was shorter than that in the control group,the incidence of complications was lower than that in the control group,and the differences were statistically significant (P<0.05).Conclusion Laparoscopic uterine artery blockage combined with myomectomy and comprehensive and meticulous care cooperation can significantly reduce the incidence of complications and shorten the length of hospital stay,so that patients can quickly return to normal life,worthy of clinical application. 2017 Vol. 24 (24): 157-160 [Abstract] ( 215 ) HTML (1 KB)  PDF (759 KB)  ( 133 ) 161 Application effect of individualized comprehensive nursing on pediatric bronchial pneumonia WANG Li, FENG Yun Objective To explore the application effect of individualized comprehensive nursing on pediatric bronchial pneumonia.Methods Children with bronchial pneumonia who were hospitalized in our hospital from January to December 2016 were selected as the study subjects.65 cases of children from January to June 2016 were control group,while 70 cases of children from July to December 2016 were intervention group.Patients in control group received routine nursing care, while patients in intervention group received individualized comprehensive nursing.The hospital stays, body temperature normal time,the disappear time of pulmonary rales,rate of complications,recurrence rate of 3 months after leave hospital,parental anxiety,the parents′ mastery of pneumonia nursing knowledge and parents′ satisfaction were compared.Results The hospital stays [(9.71±1.53)d],body temperature normal time [(6.35±1.21)d] and disappear time of pulmonary rales [(6.12±2.10)d] in the intervention group were shorter than those in the control group [(11.48±1.82),(8.87±1.33),(7.46±1.87)d],and the differences were statistically significant (P<0.01).The rate of complications (5.7%) and recurrence rate (7.1%) of 3 months after leave hospital in the intervention group were lower than those in the control group (20.0%,18.5%),and the differences were statistically significant (P<0.05).The parents′mastery scores of pneumonia nursing knowledge [(16.47±2.04) scores] and nursing satisfaction [(17.30±1.92) scores] in the intervention group were higher than those in the control group [(13.85±2.31,14.64±2.23) scores],the degree of anxiety [(45.42±3.14) scores] in the intervention group was lower than that in the control group [(52.33±3.22) scores],and the differences were statistically significant (P<0.01).Conclusion Individualized comprehensive nursing can effectively improve the treatment of children with bronchial pneumonia care effect,improve patients′ satisfaction with care,reduce the recurrence rate of pneumonia in children,and help children′s disease rehabilitation. 2017 Vol. 24 (24): 161-164 [Abstract] ( 183 ) HTML (1 KB)  PDF (754 KB)  ( 179 ) 164 Clinical application study of predictive nursing measures in the concurrent operational nursing of craniocerebral defect combined with hydrocephalus ZOU You-xiang, XIE Li-juan, LUO Yu-lan Objective To study and analyze the intervention effect and value of predictive nursing measures in the concurrent operational nursing of craniocerebral defect with hydrocephalus.Methods From January 2015 to January 2017,108 cases patients with craniocerebral defect combined with hydrocephalus operated concurrently in our hospital were selected as research objects.They were randomly divided into observation group and control group,with 54 patients in each group.All patients were treated with surgical treatment,and the control group was given routine intervention,while the observation group was coordinated with the predictive nursing intervention.The average hospital stay,hospitalization cost,satisfaction and intraoperative complications were compared between the two groups.Results There was no death case occurred in this study.Aftert herapy,patients were successfully discharged from the hospital.The average hospital stay of patients in observation group was shorter than the control group,hospitalization cost was lower than the control group,satisfaction was higher than the control group,the intraoperative complications of patients in observation group (5.56%) was lower than that in the control group (22.22%),the differences were statistical significance (P<0.05).Conclusion For patients with craniocerebral defect and hydrocephalus operated concurrently,application of predictive nursing measures as an intervention guidance can effectively improve patients′ clinical symptoms as well as prognosis,which is worthy of promotion. 2017 Vol. 24 (24): 164-166 [Abstract] ( 230 ) HTML (1 KB)  PDF (709 KB)  ( 173 ) 167 The nursing effect of Hemabate combined with uterine strap suture technique in postpartum hemorrhage of cesarean section WAN Xi-di Objective To analyze the nursing effect of Hemabate combined with uterine strap suture technique in postpartum hemorrhage of cesarean section.Methods From March 2016 to March 2017,70 cases puerperae of postpartum hemorrhage after cesarean section in our hospital as the research objects,randomly divided into control group and study group.The puerperae in control group were given oxytocin combined with traditional suture for treatment,the puerperae in study group were treated with Hemabate combined with uterine strap suture technique.The treatment effect of puerperae after treatment in two groups were analyzed and compared.Results The blood volume of puerperae in intraoperative,postoperative 2 h and postoperative 24 h in the study group were significantly lower than in the control group,the differences were statistically significant (P<0.05).The incidence of adverse reactions of puerperae in the study group (8.5%) was significantly lower than that in the control group (28.5%),and the difference was statistically significant (P<0.05).Conclusion Hemabate combined with uterine strap suture technique in postpartum hemorrhage of cesarean section has the advantages of good effect and high safety.With the corresponding nursing measures,not only increases maternal quality of life,but also increases maternal happiness index,it can be widely promoted and used in clinical practice. 2017 Vol. 24 (24): 167-169 [Abstract] ( 158 ) HTML (1 KB)  PDF (711 KB)  ( 72 ) 170 Application effect of high quality nursing in senile patients with left colon cancer complicated with intestinal obstruction PENG Qiong Objective To analyze the application effect of high quality nursing in senile patients with left colon cancer complicated with intestinal obstruction.Methods From October 2015 to November 2016,150 senile patients with left colon cancer complicated with intestinal obstruction were selected and randomly divided into observation group and control group.The patients in the observation group were treated with routine nursing and the patients in the control group were treated with high quality nursing.The application effect of nursing care was compared between the two groups.Results The complication incidence of patients in the observation group was 5.33%,it was lower than that in control group (16.00%),and the difference was statistically significant (P<0.05).In the observation group,the postoperative indwelling catheter time [(157.01±32.02)h],the average time of bed activity [(79.11±23.01)h] and the fistula exhaust time [(62.10±10.32)h] were shorter than those of the control group [(306.12±35.16),(115.45±35.02),(85.17±20.16)h],the differences were statistically significant (P<0.05).Conclusion It is not only can improve the indexes by implementing high quality nursing for senile patients with left colon cancer complicated with intestinal obstruction,but also can prevent the occurrence of complications.It is worthy of clinical promotion and application. 2017 Vol. 24 (24): 170-172 [Abstract] ( 198 ) HTML (1 KB)  PDF (712 KB)  ( 87 ) 173 The application effect on the disease assessment scale in the grading nursing with the patients in neurology department SONG Zheng-xin, WANG Min Objective To observe the effect of grading nursing on the patients in neurology department of our hospital with self-made disease assessment scale.Methods From June to December 2016,203 patients received treatment in our hospital were selected as the research objects,and divided into observation group (102 cases) and control group (101 cases) according to the chronological order of admission time.The patients in the control group were given a score according to the Barthel index evaluation scale by nurses,and the doctors rated the nursing grade on the basis of the score.The doctors in the observation group according to self-made disease assessment scale to assess the condition monitoring of consciousness,age,body temperature,heart rate,respiration,blood pressure,oxygen saturation,blood glucose,and the potential complications of patients based on the control group.The patients were divided into four levels of light,medium,heavy and dangerous level according to the scoring criteria.Based on the results of this level judgment and combination the score of Barthel index evaluation,the doctors issued the level of nursing orders and gave a nursing order.The results between the two groups of patients with nursing grade compliance rate,basic nursing qualification rate and patient satisfaction survey were compared.Results The nursing grade compliance rate,basic nursing qualification rate and patient satisfaction were all better than the control group,and the differences were statistically significant(P<0.05).Conclusion Application of the self-made disease assessment scale can make the grading nursing more detailed and standardized,also can improve the nursing quality and patients satisfaction. 2017 Vol. 24 (24): 173-175 [Abstract] ( 198 ) HTML (1 KB)  PDF (713 KB)  ( 184 ) 176 Influence of comprehensive community nursing on medication compliance and blood glucose level of patients with type 2 diabetes mellitus YANG Xiao-hong, LIU Wei-hua Objective To investigate the influence of comprehensive community nursing on medication compliance and blood sugar level in diabetic patients,and to provide reference for glycemic control and nursing mode in diabetic patients.Methods 120 patients with type 2 diabetes mellitus treated in Yantian District from May 2014 to May 2015 were randomly selected and they were divided into routine group and intervention group according to the random grouping method,and there were 60 cases in each group.Routine group was given routine medication,diet and exercise guidence,etc. while intervention group received comprehensive community nursing.Blood glucose and related indexes,medication compliance,lifestyle changes,health knowledge and cognition between the two groups were compared.Results The patients in the intervention group were fasting blood glucose to (7.88±1.45) mmol/L,and other related indicators have improved significantly compared with normal group (P<0.01).The compliance of intervention group was significantly improved,with statistical significance compared with the control group (P<0.01).Living habits in patients of the intervention group had been improved significantly,and there was statistical significance compared with the control group (P<0.05,P<0.01).Knowledge of diabetes mellitus and master degree in patients of the intervention group had been improved significantly,and there was statistical significance compared with the control group (P<0.05,P<0.01).Conclusion comprehensive community nursing path can significantly improve the blood glucose levels in diabetic patients, improve patient compliance and improve the living habits of patients, and significantly increased in patients with diabetes related knowledge, can be widely used in the daily care of diabetic patients in the community as a unit. 2017 Vol. 24 (24): 176-179 [Abstract] ( 216 ) HTML (1 KB)  PDF (754 KB)  ( 126 ) 179 Application of comprehensive nursing intervention in hemodialysis patients with permanent deep vein indwelling catheter LI Jiao Objective To evaluate the effect of permanent deep venous catheter in hemodialysis and to evaluate the nursing strategy.Methods From March 2015 to March 2016,50 hemodialysis patients in our hospital were selected as the subjects,and the patients were divided into the study group and the control group.Two groups were treated with hemodialysis were used during the permanent deep venous catheter,on this basis,the control group of hemodialysis patients were given conventional nursing intervention methods,the study of group of hemodialysis patients with comprehensive nursing intervention study.The duration of permanent deep vein indwelling catheter and adverse reactions were observed in the two groups.Results The two groups of permanent deep venous catheter indwelling time,the study group [(13.60±1.70) months] was significantly higher than the control group [(9.20±1.20) months],the difference was statistically significant (P<0.05);compare the incidence of adverse reactions of the two groups,the study group (1 cases) was significantly lower than the control group (6 cases),the difference was statistically significant(P<0.05).For hemodialysis patients with hemodialysis catheter and Conclusion application of permanent deep venous,given comprehensive nursing intervention,can effectively prolong the indwelling time,reduce the incidence of adverse reactions,worthy of further clinical promotion and application. 2017 Vol. 24 (24): 179-181 [Abstract] ( 245 ) HTML (1 KB)  PDF (753 KB)  ( 113 ) 182 Application effect of meticulous nursing care in the patients with habitual abortion CHEN Xiao-jing Objective To explore the application effect of meticulous nursing care in the patients with habitual abortion.Methods 76 patients with habitual abortion who were admitted to our hospital from June 2014 to June 2016 were randomly divided into two groups.The control group was given regular nursing care,and the observation group was given meticulous nursing care.The nursing effect was compared.Results The total effective rate in the observation group was 89.5%,significantly higher than that of 71.1% in the control group (P<0.05).SAS,SDS scores upon discharge in the observation group were both significantly lower than those in the control group (P<0.05).The nursing satisfaction rate was 94.7%,significantly higher than that of 73.7% in the control group (P<0.05).Conclusion Meticulous nursing intervention for the patients with habitual abortion can improve the therapeutic effect,promote the improvement of negative emotions and establish a harmonious nurse-patient relationship. 2017 Vol. 24 (24): 182-184 [Abstract] ( 189 ) HTML (1 KB)  PDF (711 KB)  ( 147 ) 185 Efficacy of psychological intervention on the quality of life of patients with advanced non-small cell lung cancer WANG Xing-ying, LI Jun-yu, WANG Xiao-song, QIU Juan Objective To explore the efficacy of psychological intervention on the quality of life of patients with advanced non-small cell lung cancer.Methods 80 patients with advanced NSCLC enrolled in our department of oncology from January 2014 to December 2015 were selected and divided into the control group and the observation group according to the single and double numbers of admission,with 40 cases in each group. The control group was given routine nursing care during the chemotherapy period,and the observation group was given psychological intervention on the basis of the control group.The quality of life,depression and anxiety of the patients before chemotherapy and 2 cycles after chemotherapy,the compliance behavior and short-term efficacies were compared between two groups.Results Before chemotherapy,there were no significant differences among the scores of indexes in EORTC QLQ-C30 and scores of SAS and SDS in two groups (P>0.05);after chemotherapy,the scores of indexes in EORTC QLQ-C30 in two groups were all increased,the scores of SAS and SDS were all decreased,and compared with those before chemotherapy,the differences were statistically significant (P<0.05).And the scores of indexes in EORTC QLQ-C30 in the observation group was higher than those in the control group,the scores of SAS and SDS was lower than those in the control group,and the differences were statistically significant (P<0.05).The compliance behavior in the observation group was higher than that in the control group,the disease control rate was higher than that in the control group,and the differences were statistically significant (P<0.05).There was no significant differences in the total effective rate between two groups (P>0.05).Conclusion Psychological intervention can improve the treatment compliance of patients with advanced non-small cell lung cancer,relieve anxiety and depression,improve the quality of life and disease control rate. 2017 Vol. 24 (24): 185-187 [Abstract] ( 203 ) HTML (1 KB)  PDF (715 KB)  ( 98 ) 188 Clinical application and evaluation of small-volume syringe in prevention of nasointestinal tube blocking CHEN San′e, LYU Xiao-ying, WU Wen-rong, LIU Qun-yan, WANG Li Objective To investigate the clinical application value of small-volume syringe with impulse pipe blowing in the prevention of nasointestinal tube blocking.Methods The clinical data of 100 patients with enteral nutrition through nasointestinal tube in the department of intensive care unit in Shangrao People′s Hospital in Jiangxi from June 2016 to June 2017 were retrospectively analyzed.All the patients were divided into two groups according to irrigation methods of nasointestinal tube,50 cases in each.The enteral nutrients of two groups were nutrison fibre.The control group was given uniform velocity irrigation with 50 ml syringe,while the observation group was given impulse irrigation with 10 ml syringe.The reintubation rate,indwelling time of nasointestinal tube,hospital stays,hospitalization expense,nursing satisfaction and the incidence of adverse reactions were compared between the two groups.Results The reintubation rate of the observation group was 4.00%,which was lower than 16.00% of the control group (P<0.05);the indwelling time of nasointestinal tube in the observation group was longer than that in the control group,the hospital stays were shorter than those in the control group,and the hospitalization expense was lower than that in the control group (P<0.05);the nursing satisfaction of the observation group was 90.00%,which was higher than 74.00% of the control group (P<0.05);the incidence of adverse reactions in the observation group was 6.00%,which was lower than 20.00% in the control group (P<0.05).Conclusion Small-volume syringe can effectively prevent nasointestinal tube blocking,decrease the reintubation rate,prolong the indwelling time of nasointestinal tube,relieve pain and improve nursing satisfaction,which is worthy of promotion and application. 2017 Vol. 24 (24): 188-190 [Abstract] ( 221 ) HTML (1 KB)  PDF (713 KB)  ( 136 ) 191 Analysis of effect of nursing intervention on perioperative and postoperative recovery of ectopic pregnancy laparoscopic surgery ZHOU Su-qun Objective To explore the effect of nursing intervention on the perioperative and postoperative recovery of patients undergoing ectopic pregnancy laparoscopic surgery.Methods Altogether 66 cases of patients who underwent ectopic pregnancy laparoscopic surgery in our hospital from April 24th 2015 to April 24th 2016 were selected and divided into the control group and the observation group,with 33 cases in each group.Patients in the control group were given routine nursing intervention,while patients in the observation group were given perioperative nursing intervention on the basis of the control group.The operation index,length of hospital stay,the anxiety and quaity of sleep before and after nursing were compared two groups.Results The operation time,anal exhaust time,ambulation time and length of hospital stay in the obaervation group were shorter than those in the control group,and the differences were statistically significant (P<0.05).Before nursing,there were no significant differences among the scores of SAS and PSQI in two groups (P>0.05);after nursing,the scores SAS and PSQI in the observation group were lower than those in the control group,and the differences were statistically significant (P<0.05).Conclusion Application of perioperative nursing intervention in patients with ectopic pregnancy undergoing laparoscopic surgery can shorten the operation time,anal exhaust time,ambulation time and length of hospital stay,relieve patients′negative emotion,improve nursing quality and promote postoperative recovery. 2017 Vol. 24 (24): 191-193 [Abstract] ( 160 ) HTML (1 KB)  PDF (752 KB)  ( 141 ) 194 Application of healthy life style education in medical care for high-risk patients of hypertension YI Xiao-hong, SUI Zhi-gang Objective To explore application of healthy life style education in medical care for high-risk patients of hypertension.Methods 100 patients with high risk of hypertension received physical examination in our hospital during January 2015 to January 2016 were selected as the research object and were randomly divided into the observation group and the observation group,with 50 cases in each group.The control group was given hypertension routine medical care,while the observation group was given guidance for the healthy lifestyle education program on the basis of the control group.For a period of 1 year of follow-up,the blood pressure control rate,the incidence of hypertension,quality of life and nursing satisfaction were compared between two groups.Results Before nursing,there were no significant differences in the blood pressure control rate and quality of life between two groups (P>0.05);after nursing,those in the observation group were higher than those in the control group,and the differences were statistically significant (P<0.05).The incidence of hypertension was lower than that in the control group,the nursing satisfaction was higher than that in the control group,and the differences were statistically significant (P<0.05).Conclusion Healthy lifestyle education applied to the effect of medical nursing achieved the high-risk group of hypertension significantly,improve the control effect of blood pressure in patients with essential hypertension,reduced disease incidence and greatly improve the quality of life of patients,with clinical application and popularization value. 2017 Vol. 24 (24): 194-196 [Abstract] ( 202 ) HTML (1 KB)  PDF (752 KB)  ( 113 )

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