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| Analysis of metabolic related indexes and MTHFR gene polymorphism in patients with H-type hypertension |
| LIU Ling-ling1, TANG Zhi1,2▲, XIAO Lin2, SU Qi-wen2, CHEN Wen-rong2 |
1.Department of Advanced Diagnostic and Treatment,Shunde Hospital of Southern Medical University in Guangdong Province, Shunde 528300,China;
2.The First Department of Internal Medicine,Xingtan Hospital Affiliated to Shunde Hospital of Southern Medical University in Guangdong Province, Shunde 528325,China |
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Abstract Objective To analyze the polymorphism of MTHFR gene in patients with hypertension,and to explore the relationship between H-type hypertension and metabolic biochemical indexes such as homocysteine (Hcy).Methods 100 patients with H-type hypertension and 100 patients with general hypertension treated in our hospital from July 2013 to June 2016 were selected as study subjects.Plasma homocysteine (Hcy) and blood lipids,blood glucose and other biochemical indicators were detected in two groups,and the polymorphism of MTHFR gene was compared.Results Hcy,uric acid (UA),creatinine (Cr) level in the H-type hypertension group were significantly higher than those in the general hypertension group (t=14.989,6.672,4.832,P<0.05).The frequency distribution of MTHFR 677C/T genotype frequency of the H-type hypertension group was mainly T allele,and the frequency distribution of C allele was dominant in the general hypertension group (P<0.05).Conclusion The level of Hcy,UA and Cr are closely related to the occurrence of H-type hypertension.Homozygous mutant TT genotype of MTHFR gene 677C/T may be an important genetic factor of H-type hypertension.
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Received: 12 May 2017
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| [1] |
中国高血压防治指南修订委员会.中国高血压防治指南2010年修订版[J].中华心血管病杂志,2011,39（7）：579-616.
|
| [2] |
Mc Cully KS.Homocysteine and vascular disease[J].Nature Med,1996,2（4）：386-389.
|
| [3] |
BrandI R,Probst R,Muller B, et al .Evaluation of lysatehomocysteine in patients with symptomatic arterial disease and unhealthy volunteers[J].Clin Chem,1999,45（5）：699-702.
|
| [4] |
Wald DS,Morris JK,Wald NJ.Reconciling the evidence on serum homocysteine and ischaemic heart disease[J].PLoS One,2011,6（2）：e16473
|
| [5] |
Selhub J,D′Angelo A.Relationship between homocysteine and thrombotic disease[J].Am J Med Sci,1998,316（2）：129-141.
|
| [6] |
Rodgers GM,Conn MT.Homocysteine,an atherogenic stimulus, reduces protein C activation by arterial and venous endothelial cells[J].Blood,1990,75（4）：895-901.
|
| [7] |
Qin X,Li J,Cui Y, et al .MTHFR C677T and MTR A2756G polymorphisms and the homocysteine lowering efficacy of different doses of folic acid in hypertensive Chinese adults[J]. Nutr J,2012,11：2.
|
| [8] |
Pool PE.The case for metabolic hypertension：is it time to restructure the hypertension paradigm?[J].Prog Cardiovasc Dis,1993,36（1）：1-38.
|
| [9] |
Israili ZH,Lyoussi B,Hernández-Hernández R, et al .Metabolic syndrome：treatment of hypertensive patients[J].Am J Ther,2007,14（4）：386-402.
|
| [10] |
Wilding J,Finer N.Obesity and risk of myocardial infarction：the INTERHEART study[J].Lancet,2006,367 （9516）：1053.
|
| [11] |
Mancia G,De Backer G,Dominiczak A, et al .2007 Guidelines for the management of arterial hypertension：the task force for the management of arterial hypertensionof the European Society of Hypertension （ESH） and of the European Society of Cardiology （ESC）[J].Eur Heart J,2007,28（12）：1462-1536.
|
| [12] |
Welch GN,Loscalzo J.Homocysteine and atherothrombosis[J].N Engl J Med,1998,338（15）：1042-1050.
|
| [13] |
Kelly PJ,Rosand J,Kistler JP, et al .Homocysteine,MTHFR 677C→T polymorphism,and risk of ischermic stroke：results of a meta-analysis[J].Neurology,2002,59（4）：529-536.
|
| [14] |
Den Heijer M,Letwington S,Clarke R.Homoeysteine,MTHFR and risk of venous thrombosis：a meta-analysis of published ep idemiological studies[J].J Thromb Haemost,2005,3（2）：292-299.
|
| [15] |
Faraci FM,Lentz SR.Hyperhomocysteinemia,oxidative stress,and cerebral vascular dysfunction[J].Stroke,2004,35：345-347.
|
|
|
|
