儿童急性肾损伤及早期生物标记物的临床评价

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Abstract Obiective To analyze the clinical features of pediatric acute kidney injury and to investigate the diagnostic value of biomarkers for pediatric AKI.Methods From June 2016 to March 2017,a total of 60 patients who were hospitalized in the department of pediatric in our hospital and the second xiangya hospital of central south university were selected as research objects.They were assigned to AKI group (30 cases) and non-AKI group (30 cases) according to the definition by the AKIN criteria.Also 24 healthy children of the same age were recruited as the control group.The clinical characteristics and influencing factors of AKI children were analyzed,and the biomarkers of different groups of children were observed and the diagnostic value of different biomarkers for AKI was compared.Results The common causes of AKI were sepsis,drug intoxication,severe allergic purpura and snakebite.Height and weight had a higher correlation with AKI (P<0.05).At 2 hours after hospitalization,except SCr,the levels of urine KIM-1,NGAL,L-FABP,serum CysC,and serum NGAL were significantly higher in AKI group than those in non-AKI group,and the differences were statistically significant（P<0.01).At 48 hours after hospitalization,the levels of SCr were significantly higher in AKI group than those in non-AKI group,and the differences were statistically significant（P<0.01).Although the levels of other biomarkers in AKI group declined,they were still significantly higher than those in non-AKI group,and the differences were statistically significant（P<0.01).At 2 hours after hospitalization,the value for the AUC was determined for urine KIM-1,NGAL,L-FABP,serum CysC,NGAL and SCr was 0.912,0.922,0.909,0.906,0.943 and 0.533 respectively.At 48 hours after hospitalization,the value for the AUC was determined for urine KIM-1,NGAL,L-FABP,serum CysC,NGAL and SCr was 0.887,0.904,0.858,0.818,0.889 and 0.942 respectively.Conclusion s AKI is associated with the disease severity.Height and weight may be the influence factors of pediatric AKI in renal pathologic conditions.The serum level of NGAL may have good reference value for early clinical diagnosis of AKI,SCr is still an impor tant predictor of AKI.

Key words： Acute kidney injury Children Blomarkers Clinical evaluation

Received: 14 July 2017

PACS:

R692.5

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	Articles by authors
	LIU Hua
	HE Xiao-jie
	DING Qing-xiong
	LIANG Wan-xia
	LI Guo-jun
	FAN Juan

Cite this article:

LIU Hua,HE Xiao-jie,DING Qing-xiong, et al. Clinical evaluation on pediatric acute renal injury and early biomarkers[J]. 中国当代医药, 2017, 24(24): 101-105.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2017/V24/I24/101

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