降钙素原联合C反应蛋白预测慢性阻塞性肺疾病急性加重的临床价值

Abstract
Figure/Table
References
Related Citation (1)

Download: PDF (515 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To assess the clinical value of serum procalcitonin (PCT) in combination with CRP in prediction acute exacerbation of chronic obstructive pulmonary disease (AECOPD).Methods 120 patients treated in Department of Respiratory Medicine of the Third People′s Hospital of Hubei Province from January to December 2016 were selected and they were divided into AECOPD group (n=60) and stable period group (n=60).The value of PCT,CRP and WBC count was measured in two groups and the data between the two groups was compared.At the same time,the sensitivity and specificity predicting AECOPD of various index were observed,and the correlation of PCT and CRP,WBC count were analyzed.Results PCT and CRP in AECOPD group were significantly higher than those in stable period,there was a statistical significance (P<0.05).The WBC count in AECOPD group was higher than that in stable period,but there was no statistical difference (P>0.05).The sensitivity of PCT,CRP,WBC count judging AECOPD was 87%,73% and 62% respectively,the specificity was 73%, 68% and 60% respectively.The sensitivity and specificity of PCT combined with CRP increased to 88% and 75% respectively.PCT and CRP,WBC showed a positive correlation (r=0.521,0.308,P<0.05).Conclusion Serum PCT has high sensitivity and specificity,dynamic combined detection of PCT and CRP can be used as an inflammatory indicator predicting AECOPD in early stage.

Key words： Procalcitonin C-reactive protein White blood cell count Chronic obstructive pulmonary diseases Clinical value

Received: 26 April 2017

PACS:

R563.9

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	HUANG Chun-yan
	ZHANG Cai-xia

Cite this article:

HUANG Chun-yan,ZHANG Cai-xia. Clinical value of procalcitonin combined with C-reactive protein predicting acute exacerbation of chronic obstructive pulmonary disease[J]. 中国当代医药, 2017, 24(24): 106-108.

URL:

http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2017/V24/I24/106

[1]	温晓雯,袁麟标,叶泽辉.东莞市中重度慢性阻塞性肺疾病患者合并抑郁症流行病学调查[J].中国医学创新,2014, 11（18）：90-92.
[2]	中华医学会呼吸病学分会慢性阻塞性肺疾病学组.慢性阻塞性肺疾病诊治指南（2007年修订版）[J].中华内科杂志,2007,46（7）：8-17.
[7]	桂盈凤,罗爱梅,郑佐香,等.联合检测降钙素原、C-反应蛋白及白细胞在老年细菌性肺炎早期诊断中的意义[J].当代医学,2017,23（16）：107-109.
[8]	杜娟,高伟良,冯清洲,等.降钙素原对老年呼吸机相关性肺炎早期判断病情及预后评估中的作用[J].临床荟萃,2011, 26（23）：2055-2057
[3]	Hurst JR,Donaldson GC,Perera WR, et al .Use of plasma biomarkers at exacerbation of chronic obstructive pulmonary disease[J].Am J Respir Crit Care Med,2006,174（8）：867-874.
[4]	Sethi S.Pathogensis and treatment of acute exacerbations of chronic obstructive pulmonary diseases[J].Semin Remin Respir Crit Care Med,2005,26（2）：191.
[5]	Bircan A,Gokirmak M,Kilic O, et al .C-reactive protein in patients with chronic obstructive pulmonary disease：role of infection[J].Med Pract,2008,17（3）：202.
[6]	Guven H,Altintop L,Baydin A, et al .Diagnostic value procalitonin levels as an early indicator of sepsis [J].Am J Emeg Med,2002,20（3）：202-206.
[9]	Shimetani N,Ohba Y,Shimetani K, et al .Assay for determination of the serum procalcitonin level：biochemical and clinical evaluation[J].Rinsho Byori,2001,49（1）：56-60.
[10]	Daniels JM,Schoorl M,Snijders D, et al .Procalcitonin vs C-reactive protein as predictive markers of response to antibiotic therapy in acute exacerbations of COPD[J].Chest,2010,138（5）：1108-1115.
[11]	常春,姚婉贞,陈亚红,等.血清降钙素原对慢性阻塞性肺疾病急性加重期患者下呼吸道细菌感染的诊断价值[J].中华结核和呼吸杂志,2006,38（4）：389-392.
[12]	潘华琴,姜克家,秦少云,等.慢性阻塞性肺疾病急性加重患者血清PCT、CRP水平变化及其与FEV 1 %的相关性[J].齐齐哈尔医学院学报,2014,35（22）：3285-3286.
[13]	吴少卿,文道林,曹文平.血清降钙素原和C-反应蛋白在细菌感染性疾病诊断中的意义[J].中国现代医药杂志,2009,11（4）：66-68.
[14]	余长智,吐尔滚·艾萨,吴燕,等.血清降钙素原预测慢性阻塞性肺疾病急性加重期患者院内感染的临床价值[J].中华危重症医学杂志（电子版）,2011,4（5）：9-12.
[15]	安英俊,张祥杰,李平,等.联合检测降钙素原、血沉、C-反应蛋白在下呼吸道感染中的临床意义[J].国际呼吸杂志,2013,33（6）：412-414.
[16]	马晋,张颖,张杰,等.COPD急性加重期降钙素原与超敏C反应蛋白检测临床意义[J].临床肺科杂志,2011,16（12）：1839-1840.