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Quick Search     Adv Search 2022 Vol. 29, No. 14 Published: 2022-05-18   5 Clinical application of copy number variation sequencing in patients with recurrent abortion ZHENG Xiaowei；HUANG Xiaolan；CHEN Xiaoqing Objective To explore the clinical application of copy number variation sequencing (CNV-seq) in patients with recurrent abortion (RSA). Methods A total of 420 couples with RSA treated in the Second Affiliated Hospital of Fujian Medical University from January 2018 to October 2021 were selected for peripheral blood chromosome examination and embryo abortion chromosome culture,using CNV-seq to detect embryo abortion chromosome,explore the clinical application of chromosome detection in patients with recurrent abortion. Results There were 42 abnormal karyotypes in peripheral blood of 420 couples with RSA,the positive rate was 10.0%.Among 420 couples of RSA,383 couples were successful,113 couples were abnormal karyotype,the positive rate was 29.5%.Abnormal results were found in 362 couples (86.2%) and negative results were found in 58 couples (13.8%) of 420 embryos stained by CNVseq.In 420 couples of RSA,the incidence of chromosomal abnormalities was 34.2% in the age group ≥40 years old.According to the number of abortions,the highest rate of abnormal karyotype after three abortions was 37.8%. Conclusion Chromosome abnormality of peripheral blood and embryo is an important cause of RSA.With the increase of age,the incidence of RSA is also increasing.It is of great significance to take effective genetic counseling and intervention measures to guide marriage and breeding and improve the quality of the next generation. 2022 Vol. 29 (14): 5-9 [Abstract] ( 31 ) HTML (1 KB)  PDF (606 KB)  ( 100 ) 10 Effect of Kangdaxin Oral Liquid on oxidative stress in rats with cardiorenal syndrome WU Xiang；ZHANG Tingting；XIONG Shangquan Objective To investigate the effect and potential mechanism of Kangdaxin Oral Liquid on cardiorenal syndrome (CRS) rats.Methods Sixty SD rats were randomly divided into 5 groups:sham operation (sham) group,heart failure (HF) group,CRS group,HF+intervention (I) group and CRS+I group.Left ventricular ejection fraction (LVEF)and left ventricular shortening fraction (FS) were measured by cardiac color ultrasound.The levels of serum N-terminal pro-B type natriuretic peptide (NT-proBNP),creatinine (Cr),urea nitrogen (Bun),total antioxidant capacity (TAOC),superoxide dismutase (SOD),malondialdehyde (MDA) were determined by ELISA.Results The FS and LVEF values of rats in HF group,HF+I group,CRS group and CRS+I group were lower than those in sham group,and serum NT-proBNP level was higher than that in sham group,the differences were statistically significant (P<0.05).The FS and LVEF values in HF+I group were higher than those in HF group,and the level of NT-proBNP was lower than that in HF group,the differences were statistically significant (P<0.05).The FS and LVEF values of CRS+I group were higher than those of CRS group,and the level of NT-proBNP was lower than that of CRS group,the differences were statistically significant (P<0.05).The levels of serum Cr and Bun in CRS group and CRS+I group were higher than those in sham group,and the differences were statistically significant (P<0.05).The levels of serum Cr and Bun in CRS+I group were lower than those in CRS group,the differences were statistically significant (P<0.05).Serum TAOC and SOD levels in HF group,HF+I group,CRS group and CRS+I group were lower than those in sham group,while MDA level was higher than that in sham group,the differences were statistically significant (P<0.05).Serum T-AOC and SOD levels in HF+I group were higher than those in HF group,while MDA levels were lower than those in HF group,the differences were statistically significant (P<0.05).Serum T-AOC and SOD levels in CRS+I group were higher than those in CRS group,while MDA levels were lower than those in CRS group,the differences were statistically significant (P<0.05).Conclusion Kangdaxin Oral Liquid may improve cardiac function in rats with cardiorenal syndrome by promoting antioxidant capacity and suppressing oxidative stress. 2022 Vol. 29 (14): 10-13 [Abstract] ( 28 ) HTML (1 KB)  PDF (728 KB)  ( 177 ) 14 Mechanism analysis of Taoren Honghua Decoction in the treatment of myocardial ischemia reperfusion injury based on network pharmacology and molecular docking HONG Qiuyu；WU Ya′nan；ZHAO Haoxi；WAN Xinliang Objective To analyze the mechanism of Taoren Honghua Decoction in the treatment of myocardial ischemia reperfusion injury based on network pharmacology and molecular docking.Methods The chemical components and targets of Taoren Hongghua Decoction and MIRI targets were collected by searching the database.Cytoscape 3.8.2 was used to make active components-target network diagram and protein interaction network diagram of Taoren Honghua Decoction.DAVID database was used to conduct gene ontology (GO) enrichment analysis and Kyoto encyclopedia of genes and genomes (KEGG) signaling pathway analysis on the related target.PyMol 2.5.2 and AutoDockTools 1.5.6 software were used for molecular docking of core components and core targets of Taoren Honghua decoction.Results Two hundred and one active ingredients,303 potential therapeutic target genes and 86 common targets for the treatment of MIRI were finally obtained.It was predicted that the main components of Taoren Honghua Decoction in the treatment of MIRI were quercetin,β-sitosterol,luteolin, etc. The key targets were protein kinase B (AKT1),interleukin-6(IL-6),tumor necrosis factor (TNF), etc. The results of KEGG analysis suggested that the key pathways may include TNF signaling pathway and hypoxia inducible factor-1 (HIF-1) signaling pathway, etc.Molecular docking results showed that core components and targets of Taoren Honghua Decoction might have good affinities.Conclusion This study speculated that Taoren Honghua Decoction may treat MIRI through multiple components,multiple targets and multiple pathways. 2022 Vol. 29 (14): 14-17-31 [Abstract] ( 32 ) HTML (1 KB)  PDF (1430 KB)  ( 36 ) 18 Clinical effect of acupuncture based on meridians differentiation and fire needle in the treatment of stage Ⅰshoulder-hand syndrome after stroke LIN Qin；JIANG Jingjing；HUANG Guirong Objective To investigate the related indexes and clinical effect of acupuncture based on meridians differentiation and fire needle in the treatment of stage Ⅰshoulder-hand syndrome after stroke.Methods A total of 78 patients with stage Ⅰshoulder-hand syndrome after stroke from the Rehabilitation Hospital Affiliated to Fujian University of Traditional Chinese Medicine from December 2018 to December 2020 were selected as study subjects.They were divided into treatment group and control group by random number table method,with 39 cases in each group.The control group was treated with rehabilitation training,and the treatment group was treated with rehabilitation training plus acupuncture based on meridians differentiation and fire needle.Both groups were treated for 4 weeks.The total effective rate was compared between the two groups after 4 weeks of treatment.The shoulder function,edema scores and serum inflammatory factors were compared between the two groups before and after treatment for 4 weeks.Results At the end of the treatment session,the total effective rate of the treatment group was 93.31%,which was higher than that of the control group (71.79%),the difference was statistically significant (P<0.05).The Constant-Murley scale of shoulder function (CMS) scores of the two groups after treatment were higher than those before treatment,the differences were statistically significant (P<0.05).After treatment,the shoulder-hand syndrome scale (SHSS) and edema scores in the two groups were lower than those before treatment,and the differences were statistically signific ant (P<0.05).The CMS score of the treatment group was higher than that of the control group,and the difference was statistically significant (P<0.05).SHSS and edema scores in the treatment group were lower than those in the control group after treatment,the differences were statistically significant (P<0.05).The levels of serum interleukin-6 (IL-6),tumor necrosis factor-α (TNF-α) and high-sensitivity C-reactive protein (hs-CRP) in the two groups after treatment were lower than those before treatment,the differences were statistically significant (P<0.05).After treatment,the levels of IL-6,TNF-α and hs-CRP in the treatment group were lower than those in the control group,the differences were statistically significant (P<0.05).Conclusion Acupuncture based on meridians differentiation and fire needle has obvious clinical effect on stage Ⅰshoulder-hand syndrome after stroke,and has obvious effect on improving shoulder joint function and reducing inflammatory reaction. 2022 Vol. 29 (14): 18-21 [Abstract] ( 28 ) HTML (1 KB)  PDF (573 KB)  ( 38 ) 22 Effect analysis of low molecular-weight heparin in the treatment of patients with early onset severe preeclampsia LIU Jing；ZHANG Yali；WANG Yuwei；LIANG Kuixiang Objective To explore the diagnosis and treatment of low molecular-weight heparin (LMWH) early onset severe preeclampsia (EOSP) patients curative effect analysis.Methods The clinical data of 72 patients with EOSP who received treatment in Binzhou Medical School Affiliated Hospital from January 2020 to August 2021 were retrospectively analyzed.Thirty six patients receiving conventional treatment were selected as the control group,and thirty six patients receiving low-molecular-weight heparin in addition to conventional treatment were selected as the observation group.Blood pressure,24 h urine protein,amniotic fluid volume,blood coagulation and fibrinolysis function indexes,umbilical artery blood flow indexes and adverse outcomes of maternal and infant were compared between the two groups.Results Each index of two groups of patients before treatment,there was no statistically significant difference(P>0.05).After treatment,the blood pressure,24 hours urinary protein quantitative,plasma fibrinogen (FIB),D-dimer(D-D) and umbilical artery blood flow index of the observation group were lower than before treatment,and the sheep water,activated partial clotting enzyme live time (APTT),prothrombin time (PT) were higher than before treatment,the differences was statistically significant (P<0.05).After treatment,the blood pressure,24 hours urinary protein quantitative,plasma fibrinogen (FIB) and umbilical artery blood flow indicators below of the control group were lower than before treatment,the sheep water was higher than before treatment,the differences were statistically significant (P<0.05).There were no statistically significant difference in D-D,APTT and PT of control group before and after the treatment(P>0.05).After treatment,the blood pressure,24 hours urinary protein quantitative,FIB,D-D and umbilical artery blood flow index of the observation group were lower than those of the control group,and the sheep water,APTT,PT were higher than those of the control group,the differences was statistically significant (P<0.05).After treatment,the incidence of maternal complications and neonatal adverse outcomes in observation group were lower than those in the control group,the differences were statistically significant (P<0.05).Conclusion LMWH treatment of EOSP has a significant therapeutic effect,it can obviously reduce the patient′s blood pressure levels and 24 hours urinary protein quantitative,significantly increase the sheep water,effectively improve blood coagulation fibrinolytic related indicators and related parameters of umbilical artery blood flow,it can gradually restore has damaged fetus-placental blood circulation for the growth and development of the fetus in the womb,it also may be extended appropriately gestational age,reducing the occurrence of aderse outcome mother son,worthy of clinical popularization and application. 2022 Vol. 29 (14): 22-26 [Abstract] ( 27 ) HTML (1 KB)  PDF (573 KB)  ( 67 ) 27 Research progress on mesenchymal stem cells in tumor treatment HUANG Zhongkai；XU Yechi；XU Shouyu；ZHU Rusen As a kind of pluripotent stem cells,mesenchymal stem cells (MSCs) have a wide range of biological functions.In the treatment of intracerebral tumors,the existence of blood brain barrier (BBB) hinders the diffusion of drugs to intracranial tumors,and drugs are difficult to achieve effective treatment.MSCs can bypass the BBB,so they can be used as drug carriers in the treatment of intracranial tumors.The genetically modified MSCs can migrate to the local tumor and play a therapeutic role,significantly reducing the toxic side effects on normal cells.Based on the existing studies,MSCs have a broad prospect in the application of tumor treatment.This paper reviews the interaction between MSCs and tumor cells,the effect of MSCs on the tumor microenvironment,the application of MSCs as drug carrier in tumor treatment,the genetically modified MSCs in tumor treatment,and the extracellular vesicles(EVs)secreted by MSCs in tumor treatment and other aspects of research progress. 2022 Vol. 29 (14): 27-31 [Abstract] ( 34 ) HTML (1 KB)  PDF (480 KB)  ( 114 ) 32 Research progress on the role of glycosylated albumin in diabetic complication LI Huiwei；LIU Changmei；QIN Ming Diabetes mellitus is a chronic disease characterized by metabolic disorders such as insulin resistance and elevated blood sugar,and the existence of complications is its main risk factor.High blood glucose level is closely related to atherosclerosis.About 20% to 40% of diabetic patients in China are complicated with diabetic nephropathy.And some people with type 2 diabetes as early as in primary disease diagnosis before merger diabetic retinopathy,glycated albumin is a short-term glucose metabolism in patients with diabetes control a good indicator of the level of glycosylated protein as a cycle,the main composition,through a variety of ways in the development of diabetic complications plays an important role.The relationship between diabetes and inflammation and biomarkers has been described in many studies in recent years.In this paper,the role of glycosylated albumin in the development and development of common diabetic complications such as coronary heart disease,diabetic retinopathy and diabetic nephropathy was reviewed by using inflammation as a clue. 2022 Vol. 29 (14): 32-35 [Abstract] ( 30 ) HTML (1 KB)  PDF (468 KB)  ( 46 ) 36 Advances in etiology and pathology of endometriosis complicated with infertility LIU Haiyan As a common clinical difficulty in gynecology,endometriosis has a high recurrence rate and is difficult to cure,especially endangering the reproductive health of women in their reproductive period.Therefore,improving the pregnancy rate of infertility patients with endometriosis has become one of the hot topics in the field of obstetrics and gynecology.At present,the pathogenesis of endometriosis is not very clear,and the etiology and pathology of infertility are more complex.With the progress of molecular biology,immunology,genetics and other medical fields,the research development of endometriosis and infertility and other related etiology and pathology has made a lot of research achievements.Endometriosis is abnormal in neuroendocrine function,pelvic structure,immune factors and other aspects,resulting in changes in the structure and function of female reproductive organs,which interferes with the reproductive function of patients with endometriosis from many aspects and angles.This article through to the relevant research literature at home and abroad in recent years were reviewed,aimed at in patients with endometriosis with infertility etiology,pathology,more in-depth research,so as to provide effective clinical treatment of endometriosis infertility reference,to better meet the needs of patients with endometriosis on bearing.Endometriosis,as a difficult gynecological clinical disease,has a high recurrence rate and is difficult to cure,especially endangering the reproductive health of reproductive women.Therefore,improving the pregnancy rate of endometriosis infertility has become one of the hotspots in the field of obstetrics and gynecology.At present,the etiology and pathology of endometriosis are not very clear,also the etiology and pathology of combined infertility are more complex.With the increasing progress in medical fields such as molecular biology,immunology and genetics,a large number of research results have been obtained.Endometriosis is abnormal in neuroendocrine function,pelvic structure and immune factors,which leads to the changes of fEMsale reproductive organ structure and function,and interferes with the reproductive function of patients with endometriosis from many aspects and angles.Through the review of relevant research literature at home and abroad in recent years,this paper aims to make a more in-depth study on the etiology and pathology of patients with endometriosis complicated with infertility,in order to provide effective reference and reference for the clinical treatment of endometriotic infertility,so as to better meet the reproductive needs of patients with endometriosis. 2022 Vol. 29 (14): 36-40 [Abstract] ( 26 ) HTML (1 KB)  PDF (501 KB)  ( 41 ) 41 Application effect of shumin expert imported medical repair dressing in patients with facial recurrent dermatitis WEN Xiaoyi；LIU Juhua；WANG Xiaobing；LI Guang；ZHU Yongjun；LI Yan；DING Min；WAN Yanfang Objective To explore the application effect of shumin expert imported medical repair dressing in patients with facial recurrent dermatitis.Methods A total of 92 patients with recurrent facial dermatitis admitted to Jiangxi Provincial Hospital of Dermatology from July 2019 to July 2021 were selected as the research subjects,and were divided into control group and treatment group according to random number table,with 46 cases in each group.The control group was treated with oral Medloratadine Tablets and Vitamin E Cream made by the hospital.The treatment group oral Medloratadine Tablets,with shumin expert imported medical repair dressing.Both groups were treated for 4 weeks.The clinical effect,main skin lesion symptom scores,skin biological indexes (cuticle moisture content,transdermal water loss[TEWL],oil content,erythema volume),serum immunoglobulin E (IgE) and peripheral blood eosinophils (EOS) were compared between the two groups.Results The total effective rate of treatment group was higher than that of control group,the difference was statistically significant (P<0.05).After treatment,the scores of burning,itching,tension and erythema in treatment group were lower than those in control group,the differences were statistically significant (P<0.05).After treatment,the amount of TEWL and erythema in the treatment group was lower than that in the control group,the content of oil and corneum water were higher than that in the control group,and the EOS and IgE in peripheral blood were lower than those in the control group,the differences were statistically significant (P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups (P>0.05).Conclusion Shumin expert imported medical repair dressing can improve the skin barrier function,safe and effective,worthy of promotion. 2022 Vol. 29 (14): 41-45 [Abstract] ( 41 ) HTML (1 KB)  PDF (576 KB)  ( 89 ) 46 Effect of core muscle elasticity with resistance training combined with respiratory training instrument on exercise endurance and ventilation function in patients with chronic obstructive pulmonary disease LIAO Jinhua；LIU Wanzi；FU Chaoqun；ZHU Qiqi Objective To explore the application effect of core muscle elastic band resistance training combined with respiratory training instrument in improving exercise endurance and ventilation function of patients with chronic obstructive pulmonary disease (COPD).Methods A total of 80 COPD patients admitted to Jiujiang Third People′s Hospital from January 2019 to January 2021 were selected as the research objects,they were divided into the control group and the study group using the random number table method,with 40 cases in each group.The control group was given core muscle elasticity with resistance training,the research group was treated with respiratory training instrument on the basis of the control group.The lung function,exercise endurance,sleep quality,adverse reactions,chronic obstructive pulmonary disease assessment test (CAT) score and Borg score were compared between the two groups.Results Before treatment,there were no significant differences in forced expiratory volume at the first second (FEV1),percentage of forced expiratory volume at the first second (FEV1/FVC),residual air volume (RV) and maximum volume per minute(MVV) between the two groups (P>0.05).After treatment,FEV1,FEV1%,FEV1/FVC and MVV in the two groups were higher than before treatment,RV was lower than before treatment,and FEV1,FEV1%,FEV1/FVC and MVV in study group were higher than those in control group,RV was lower than that in control group,the differences were statistically significant (P<0.05).Before treatment,there were no statistically significant differences between the two groups in the maximum exercise time (Tmax) calculated by timing method,the maximum exercise power (Wmax) measured by heart rate reserve method,and the 6 min walking test (6MWT) measured by metaslimatic method (P>0.05).After treatment,Tmax,Wmax and 6MWT in both groups were higher than before treatment,and Tmax,Wmax and 6MWT in the study group were higher than those in the control group,with statistical significances (P<0.05).The sleep quality grade of the study group was higher than that of the control group,and the difference was statistically significant (P<0.05).Before treatment,there were no significant difference in CAT score and Borg score between the two groups (P>0.05).After treatment,CAT and Borg scores in both groups were lower than those before treatment,and those in the study group were lower than those in the control group,the differences were statistically significant (P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups after treatment (P>0.05).Conclusion Core muscle elastic band resistance training combined with Respiratory training instrument has a definite effect in the treatment of COPD patients.It can not only improve lung function,improve patient exercise endurance and ventilation function,but also has fewer adverse reactions and high safety.It is worthy of clinical application. 2022 Vol. 29 (14): 46-50-54 [Abstract] ( 27 ) HTML (1 KB)  PDF (646 KB)  ( 277 ) 51 Application effect of noninvasive positive pressure ventilation combined with low-dose adrenaline in the treatment of severe asthma with respiratory failure CHEN Lian Objective To investigate the effect of noninvasive positive pressure ventilation combined with low-dose adrenaline in the treatment of severe asthma with respiratory failure.Methods A total of 1000 patients with severe asthma with respiratory failure treated in the First Affiliated Hospital of Fujian Medical University from March 2020 to April 2021 were randomly divided into observation group (500 cases) and control group (500 cases) by random number table method.The observation group was treated with noninvasive positive pressure ventilation combined with low-dose adrenaline,and the control group was treated with low-dose adrenaline.The clinical efficacy,arterial partial pressure of oxygen (PaO2),arterial partial pressure of carbon dioxide (PaCO2),pH and the incidence of complications (pneumothorax,bronchitis and atelectasis) were compared between the two groups before and after treatment.Results The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant (P<0.05).After 3 days of treatment,the PaO2 and pH values of the two groups were higher than those before treatment,and the PaO2 and pH values of the observation group were higher than those of the control group after 3 days of treatment,and the differences were statistically significant (P<0.05).After 3 days of treatment,the PaCO2 in the two groups was lower than that before treatment,and the PaCO2 in the observation group was lower than that in the control group after 3 days of treatment,and the difference was statistically significant (P<0.05).The total incidence of complications in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Noninvasive positive pressure ventilation combined with low-dose adrenaline in the treatment of severe asthma with respiratory failure can improve the blood gas index,reduce the incidence of complications and improve the therapeutic effect. 2022 Vol. 29 (14): 51-54 [Abstract] ( 30 ) HTML (1 KB)  PDF (603 KB)  ( 26 ) 55 Therapeutic effect of Linezolid combined with Cycloserine in patients with drug-resistant pulmonary tuberculosis and its effect on serum interleukin-6 and γ interferon levels LAI Jinmei；LUO lanyu；LIU Jinhua Objective To investigate the therapeutic effect of Linezolid combined with Cycloserine in drug-resistant pulmonary tuberculosis patients and the effect on serum interleukin-6 (IL-6) and γ interferon (IFN-γ) levels.Methods A total of 82 patients with drug-resistant pulmonary tuberculosis admitted to Second Hospital of Longyan City,Fujian Province from December 2017 to December 2020 were selected and divided into study group and control group according to the random number table method,with 41 cases in each group.The control group was treated with Cycloserine,and the study group was treated with Cycloserine + Linezolid,both of which continued to be treated for 6 months.The clinical efficacy,recovery of clinical symptoms,IL-6,IFN-γ and adverse reactions were compared between the two groups.Results The total effective rate of treatment in the study group was higher than that in the control group,the absorption of lesions,sputum culture and acid-fast staining smears were shorter than those in the control group,and the differences were statistically significant (P<0.05).Before treatment,there was no significant difference in serum IL-6 and IFN-γ levels between the two groups (P>0.05);after treatment,the serum IL-6 and IFN-γ levels in the study group were lower than those in the control group,and the differences were statistically significant (P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups (P>0.05).Conclusion Linezolid combined with Cycloserine is effective in the treatment of drug-resistant pulmonary tuberculosis.It can improve the clinical symptoms of patients,reduce serum IL-6 and IFN-γ levels,and is safe and reliable. 2022 Vol. 29 (14): 55-57-62 [Abstract] ( 30 ) HTML (1 KB)  PDF (586 KB)  ( 29 ) 58 Effect of different doses of Metoprolol combined with Vildagliptin in the treatment of coronary heart disease complicated with diabetes ZHOU Liyu Objective To explore the effect of different doses of Metoprolol combined with Vildagliptin in the treatment of coronary heart disease complicated with diabetes.Methods A total of 110 patients with coronary heart disease complicated with diabetes in Tengzhou Hospital of Traditional Chinese Medicine from May 2019 to February 2021 were selected as the research subjects,and were divided into study group and routine group according to random number table method,with 55 patients in each group.Both groups were treated with Vildagliptin combined with Metoprolol,the dosage of Metoprolol in the study group was 12.5 mg/time,twice a day.The dosage of Metoprolol in conventional group was 25 mg/time,twice a day.Treatment effect,cardiac function indexes (left ventricular ejection fraction[LVEF],left ventricular end-systolic diameter[LVESD],left ventricular end-diastolic diameter[LVEDD]),blood glucose indexes(fasting blood glucose[FPG],2 h postprandial blood glucose[2 h PG],glycosylated hemoglobin[HbA1c]),total incidence of adverse reactions,and serum inflammatory factors (Interleukin-6[IL-6],interleukin-8[IL-8],C-reactive protein[CRP]and tumor necrosis factor-α[TNF-α]) before and after treatment were compared between two groups.Results There was no significant difference in the total effective rate between two groups (P>0.05).The levels of FPG,2 h PG and HbA1c in two groups after treatment were lower than those before,and the levels of FPG,2 h PG and HbA1c in the study group were lower than those in the conventional group after treatment,the differences were statistically significant (P<0.05).After treatment,LVEF in the study group was higher than that in the conventional group,LVESD,LVEDD in the study group were lower than those in the conventional group,the differences were statistically significant(P<0.05).The total incidence of adverse reactions in the study group was lower than that in the conventional group,the difference was statistically significant (P<0.05).After treatment,the levels of IL-6,IL-8,CRP and TNF-α in two groups were lower than those before,and the levels of IL-6,IL-8,CRP and TNF-α in study group were lower than those in control group,the differences were statistically significant (P<0.05).Conclusion When different doses of Metoprolol combined with Vildagliptin in the treatment of patients with coronary heart disease complicated with diabetes,the dose should be controlled at 12.5 mg/time,which can not only ensure the therapeutic effect,but also improve the control level of blood glucose in patients,help to reduce the incidence of adverse reactions in patients and improve the level of inflammatory factors in patients. 2022 Vol. 29 (14): 58-62 [Abstract] ( 29 ) HTML (1 KB)  PDF (614 KB)  ( 57 ) 63 Clinical effect of high saphenous vein ligation combined with intravenous laser in the treatment of varicose veins of lower extremities ZANG Peng；GU Yan； DU Lixin；SHI Yinqing；ZHANG Haijiang Objective To investigate the clinical effect of high saphenous vein ligation combined with intravenous laser in the treatment of varicose veins of the lower extremities.Methods A total of 281 patients with varicose veins of the lower extremities admitted to the Department of General Surgery of the Third People′s Hospital of Datong City from November 2017 to November 2020 were selected as research objects.The patients were numbered according to the order in which they visited,and they were divided into the control group (n=141) and the observation group (n=140) according to the odd and even numbers.The control group was treated with high saphenous vein ligation and stripping,and the observation group was treated with high saphenous vein ligation combined with intravenous laser treatment.The two groups were followed up for 6 months.Treatment effect,chronic venous insufficiency questionnaire (CIVIQ) score,recurrence rate,surgery-related indicators and the incidence of postoperative complications were compared between the two groups.Results The superficial ulcer healing rate of the observation group was higher than that of the control group,the difference was statistically significant (P<0.05).The total operation time,total hospital stay of the observation group were shorter than those of the control group,intraoperative blood loss was less than that of the control group,and the incidence of complications were lower than those of the control group,the differences were statistically significant(P<0.05).There was no significant difference in the preoperative CIVIQ score between the two groups (P>0.05).At 6 months after operation,the CIVIQ score of the two groups was higher than that before operation,and the CIVIQ score of the observation group was higher than that of the control group,the differences were statistically significant (P<0.05).Conclusion Intravenous laser combined with high saphenous vein ligation for the treatment of varicose veins of the lower extremities can improve the treatment effect of patients,shorten the operation time and hospital stay,reduce the amount of intraoperative blood loss,and further improve the patients′ prognosis. 2022 Vol. 29 (14): 63-66 [Abstract] ( 28 ) HTML (1 KB)  PDF (461 KB)  ( 58 ) 67 Application effect of plasma needle electrode in precise excision of lateral wall tumor of bladder CHEN Xingxi Objective To investigate the application of plasma needle electrode in the treatment of lateral wall tumors of bladder.Methods A total of 52 patients with lateral bladder wall tumor adimitted to Yulin Hospital of Traditional Chinese Medicine from October 2015 to October 2020 were selected retrospectively as research objects.According to different surgical methods,they were divided into control group (conventional tumor resection) and observation group(precise plasma needle electrode resection),with 26 cases in each group.The perioperative indicators,therapeutic effect and incidence of perioperative adverse reactions were compared between the two groups.Results The operation time,bladder flushing time,catheter indwelling time,hematuria time and hospital stay in the observation group were shorter than those of the control group,and the amount of blood loss in the operation was lower than that in the control group,the differences were statistically significant (P<0.05).The total effective rate of observation group was higher than that of control group,the difference was statistically significant (P<0.05).The incidence of bladder perforation,tumor recurrence and obturator nerve injury in the observation group was lower than that in the control group,and the difference was statistically significant (P<0.05).Conclusion The clinical application of plasma needle electrodes for precise removal of bladder wall tumors has the characteristics of less operation time,significant therapeutic effect,and low incidence of adverse reactions.It is worthy of popularization and application. 2022 Vol. 29 (14): 67-69 [Abstract] ( 31 ) HTML (1 KB)  PDF (451 KB)  ( 38 ) 70 Application effect of pre-heating with inflatable heating device in percutaneous nephrolithotomy and its influence on core body temperature and stress response during operation TANG Guixiang；HUANG Yongyi；LUN Chuyi；LI Yunjie Objective To investigate the application effect of inflatable heater pre-heating in percutaneous nephrolithotriptomy (PCNL) and its effect on the changes of core body temperature and stress response of patients during operation.Methods A total of 160 cases of patients admitted to Yunfu People′s Hospital for PCNL from January 2020 and September 2021 were selected as the research objects,they were divided into the observation group and control group according to the random number table method,with 80 cases in each group.Control group uses conventional heat preservation measures,observation group uses temperature aeration and pre-heating assisted surgery,the changes of core body temperature between the two groups were recorded and compared,30,60 and 90 min after induction of anesthesia,and the perioperative clinical indicators such as operation time,intraoperative blood loss,infusion volume,flushing fluid volume,anesthesia recovery time and hospital stay were compared between the two groups.The occurrence of intraoperative hypothermia,slow body temperature recovery,postoperative chills and other stress reactions were compared between the two groups.Results There was no significant difference in core body temperature between the two groups after 30 min of induction of anesthesia (P>0.05).The core body temperature of the observation group was higher than that of the control group after 60 and 90 min of induction of anesthesia,and the difference was statistically significant (P<0.05).The observation group′s recovery time from anesthesia and hospital stay were shorter than those of the control group,and the differences were statistically significant (P<0.05).There were no statistically significant differences in the operation time,intraoperative blood loss,infusion volume,and irrigation volume between the two groups(P>0.05).The total incidence of stress reaction in the observation group was 12.50% (10/80),which was lower than 27.50% (22/80) in the control group,the difference was statistically significant (P<0.05).Conclusion Intraoperative use of inflatable thermometer for patients in PCNL with pre-heating can effectively maintain the intraoperative core body temperature level,this auxiliary equipment does not affect the normal operation process,but can effectively promote the emergence and shorten the postoperative hospital stay,the risk of intraoperative and postoperative stress reaction is lower after pre-heating with inflatable heater,which is more conducive to postoperative recovery,and has high clinical application value. 2022 Vol. 29 (14): 70-73 [Abstract] ( 33 ) HTML (1 KB)  PDF (461 KB)  ( 91 ) 74 Application effect of Lenglu Liangxiao Power combined with manual reduction and small splint external fixation in the treatment of early Smith fracture WANG Yi；ZHOU Xijiang Objective To investigate the curative effect of Lenglu Liangxiao Power combined with manual reduction and external fixation with small splint in the treatment of Smith fracture in the early stage.Methods From January 2020 to July 2021,60 patients with flexion-type distal radius fractures who were admitted to the First Inpatient Department of Trauma,South Branch,Changsha Hospital of Traditional Chinese Medicine were selected as the research objects.They were divided into control group and experimental group by random number table method,30 cases in each group.The experimental group was given Lenglu Liangxiao Power combined with manual reduction and small splint fixation,while the control group was only given manual reduction and small splint external fixation combined with ice application.All patients were observed 10 d after surgery,and the relationship between the swelling degree of affected limb,the excellent and good rate of visual analog scale (VAS) score and the anatomical structure of wrist joints between the two groups were compared.Results On day 3rd,5th,7th and 10th after treatment,the swelling degree of affected limb in experimental group was lower than that in control group,the difference was statistically significant (P<0.01).On day 3rd,5th and 10th after treatment,VAS score of experimental group was higher than that of control group,the difference was statistically significant (P<0.05).On the 1st,5th and 10th day after reduction,there was no statistically significant difference in wrist anatomical structure between the two groups (P>0.05).Conclusion Lenglu Liangxiao Power has the effect of promoting blood circulation and removing blood stasis,reducing swelling and relieving pain,promoting fracture healing,and is an effective treatment for early swelling and pain of fracture. 2022 Vol. 29 (14): 74-77 [Abstract] ( 31 ) HTML (1 KB)  PDF (577 KB)  ( 27 ) 78 Effect of self-made Huoxue Decoction on prevention of deep vein thrombosis after internal fixation of unstable femoral neck fractures XU Tong；HE Honglu；WU Jie′an Objective To explore the effect of self-made Huoxue Decoction on prevention of deep vein thrombosis(DVT) after internal fixation of unstable femoral neck fractures.Methods A total of 86 patients with unstable femoral neck fractures undergoing internal fixation in Shangrao Hospital of Traditional Chinese Medicine were enrolled between February 2018 and May 2021.According to simple random grouping method,they were divided into observation group and control group,with 43 cases in each group.After surgery,control group was treated with low-molecular weight Heparin Calcium,while observation group was treated with self-made Huoxue Decoction on basis of control group.All were continuously intervened for 2 weeks.DVT formation,plasma activated partial thrombin time (APTT),prothrombin time (PT),thrombin time (TT),fibrinogen (FIB),D-dimer (D-D) and the incidence of adverse reactions in the two groups were compared.Results The incidence of postoperative DVT in observation group was lower than that in control group,and the difference was statistically significant (P<0.05).After intervention,APTT,PT and TT in observation group were higher than those in control group,while FIB and D-D were lower than those in control group,the differences were statistically significant (P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05).Conclusion Self-made Huoxue Decoction can improve plasma hypercoagulable state and prevent DVT in patients with unstable femoral neck fractures after internal fixation. 2022 Vol. 29 (14): 78-80 [Abstract] ( 30 ) HTML (1 KB)  PDF (563 KB)  ( 31 ) 81 Effect of arthroscopic-assisted minimally invasive percutaneous closed reduction in the treatment of non-severely comminuted patellar fractures(fragments ≤3 pieces) WANG Haichuan；SANG Yuantian Objective To investigate the effect of arthroscopic-assisted minimally invasive percutaneous closed reduction in the treatment of non-severely comminuted patellar fractures (fragments ≤3 pieces).Methods A total of 56 patients with non-severe comminuted patella fractures (fragments ≤3 pieces) admitted to the Fifth People′s Hospital of Dalian City from May 2014 to May 2018 were selected as the research subjects for retrospective analysis.The patients were divided into an arthroscopic group (30 cases) and a percutaneous group (26 cases) based on different surgical methods.The patients in the arthroscopic group were treated with arthroscopic-assisted minimally invasive percutaneous closed reduction,and the patients in the percutaneous group were treated with minimally invasive percutaneous closed reduction under fluoroscope.They were both fixed with cannulated screws and titanium cable.The operation time,intraoperative fluoroscopic times,intraoperative blood loss,incision length,postoperative incision healing time,bone healing time were compared between the two groups.The total incidence of postoperative complications and the total incidence of postoperative comorbidity were compared between the two groups.According to the knee joint score of Hospital for Special Surgery in New York (HSS),the excellent rate and good rate of postoperative knee joint function in the two groups were investigated.Results There were no significant differences in operative time,intraoperative blood loss,incision length,postoperative incision healing time and bone healing time between the two groups (P>0.05).The number of intraoperative fluoroscopy in arthroscopy group was less than that in percutaneous group,and the difference was statistically significant (P<0.05).The total incidence rates of postoperative complications and postoperative comorbidity in arthroscopy group were lower than those in percutaneous group,with statistical significances (P<0.05).There were no significant differences in the excellent rate and good rate of knee function between the two groups (P>0.05).Conclusion Arthroscopic-assisted minimally invasive percutaneous closed reduction and minimally invasive percutaneous closed reduction under fluoroscope method can be used in the treatment of non-severely comminuted patellar fractures (fragments ≤3 pieces),but arthroscopic-assisted minimally invasive percutaneous closed reduction has fewer intraoperative fluoroscopy times and lower incidence of postoperative complications and comorbidity,which is recommended for clinical application. 2022 Vol. 29 (14): 81-85 [Abstract] ( 30 ) HTML (1 KB)  PDF (557 KB)  ( 22 ) 86 Effect comparison of minimally invasive surgery-ransforaminal decompression lumbar fusion and internal fixation and internal fixation with traditional open posterior approach for treatment of elderly patients with degenerative diseases of the lumbar spine MU Shengkai；WANG Jingxu；GONG Shuyi；SHEN Yongle Objective To compare the effect of minimally invasive surgery-ransforaminal decompression lumbar fusion and internal fixation (MIS-TLIF) with traditional open posterior approach for the treatment of elderly patients with degenerative diseases of the lumbar spine.Methods A total of 120 elderly patients with degenerative diseases of the lumbar spine in Shenyang Orthopaedic Hospital from November 2019 to October 2020 were selected as the research subjects,and they were divided into the control group (n=60) and the study group (n=60) by the random number table method.The control group was treated with traditional open posterior approach,and the study group was treated with MIS-TLIF.The clinical indicators of the two groups were compared,and the pain degree and quality of life before treatment and 1,3 months after treatment of the two groups were compared.Results The operative time of patients in the study group was (138.1±32.4) min,and the hospital stay was (7.4±3.0) d,which were shorter than (145.2±32.8) min and (9.8±2.5) d in the control group,and the differences were statistically significant (P<0.05).The intraoperative blood loss of patients in the study group was (253.6±121.9) ml,and the postoperative drainage volume was (24.8±8.2) ml,which were lower than (384.5±148.7) and (279.4±51.5) ml in the control group,and the differences were statistically significant (P<0.05).The incision length in the study group was (2.0±0.4) cm,which was smaller than (7.6±1.2) cm in the control group,and the difference was statistically significant (P<0.05).The visual analog scale (VAS)scores of patients in the study group at 1 and 3 months after treatment were (1.6±0.8) and (1.4±0.2) points,respectively,which were lower than (4.7±0.9) and (4.0±0.8) points in the control group,and the differences were statistically significant (P<0.05).The Oswestry disability index (ODI) scores of patients in the study group at 1 and 3 months after treatment were (34.1±4.2) and (28.6±3.4) points,respectively,which were lower than (38.3±4.3) and (33.1±3.6) points in the control group,with statistically significant differences (P<0.05).The VAS and ODI scores at 1 and 3 months after treatment in the two groups were lower than those before treatment,and the differences were statistically significant (P<0.05).The VAS and ODI scores of the two groups at 3 months after treatment were lower than those at 1 month after treatment,and the differences were statistically significant (P<0.05).Conclusion The application of MIS-TLIF in the treatment of elderly patients with degenerative diseases of the lumbar spine has a good clinical effect,and can effectively reduce the pain of patients and improve the quality of life of patients,which is worthy of clinical application. 2022 Vol. 29 (14): 86-89 [Abstract] ( 24 ) HTML (1 KB)  PDF (541 KB)  ( 21 ) 90 Effect of Recombinant Human Thrombocytopenia in the treatment of acute leukemia with thrombocytopenia after chemotherapy QI Yonglei；ZHAO Ying Objective To investigate the effect of Recombinant Human Thrombopoietin in the treatment of acute leukemia with thrombocytopenia after chemotherapy.Methods A total of 60 acute leukemia patients with thrombocytopenia after chemotherapy in the Department of Hematologic Lymphoma of the First People′s Hospital of Foshan City from January 2019 to January 2021 were selected as the study subjects,and they were divided into observation group(30 cases) and control group (30 cases) by computer two-color ball grouping method.The patients in the observation group were treated with Recombinant Human Thrombopoietin,and the patients in the control group were treated with Recombinant Human Interleukin-11.The platelet improvement time,platelet levels before and after treatment and adverse drug reactions were compared between the two groups.Results The times of duration of of platelet index below 50×109/L and platelet index recovery to 70×109/L in the observation group were shorter than those in the control group,and the differences were statistically significant (P<0.05).The level of platelet in the two groups after treatment were higher than those before treatment,the differences were statistically significant (P<0.05).The level of platelet in observation group was higher than that in the control group after treatment,the difference was statistically significant (P<0.05).The total incidence of adverse drug reactions in observation group was lower than that in control group,the difference was statistically significant (P<0.05).Conclusion Recombinant Human Thrombopoietin is effective and safe in the treatment of acute leukemia with thrombocytopenia after chemotherapy. 2022 Vol. 29 (14): 90-92 [Abstract] ( 28 ) HTML (1 KB)  PDF (427 KB)  ( 66 ) 93 Clinical effect of Tegafur combined with Apatinib in the maintenance therapy of stage Ⅲcervical cancer CHEN Chen；WANG Haoyuan；LIANG Meichang Objective To investigate the clinical effect of Tegafur combined with Apatinib in the maintenance therapy of stage Ⅲcervical cancer.Methods The clinical data of 65 patients with cervical cancer admitted to Jiangmen Central Hospital from January 2016 to June 2017 were retrospectively analyzed.They were divided into control group (n=30) and maintenance chemotherapy group (n=35) according to different treatment methods.Both groups received the same regimens of chemoradiotherapy.After the end of chemoradiotherapy,the control group underwent regular reexamination,and the maintenance chemotherapy group received maintenance treatment of Tegafur combined with Apatinib.Treatment effect,quality of life score,progression-free survival and incidence of adverse reactions were compared between the two groups.Results The total effective rate of maintenance chemotherapy group was 71.43%,higher than 36.67% of control group,the difference was statistically significant (P<0.05).The quality of life score of the maintenance chemotherapy group was higher than that of the control group,the difference was statistically significant (P<0.05).Progression-free survival was (11.46±2.01) months in the maintenance chemotherapy group,longer than (9.35±1.24) months in the control group,the difference was statistically significant (P<0.05).There was no significant difference in the incidence of bone marrow suppression,edema,gastrointestinal reaction and hypertension between the two groups (P>0.05).The incidence of hand-foot syndrome in the maintenance chemotherapy group was higher than that in the control group,the difference was statistically significant (P<0.05).Conclusion In patients with stage Ⅲcervical cancer,maintenance therapy with Tegafur combined with Apatinib is effective,beneficial to improve quality of life and prolong survival time without increasing serious adverse reactions. 2022 Vol. 29 (14): 93-95-103 [Abstract] ( 25 ) HTML (1 KB)  PDF (856 KB)  ( 13 ) 96 Expression and diagnostic value of serum miRNA-187 and miRNA-143 in patients with gallbladder cancer GE Xin Objective To study expression and diagnostic value of serum miRNA-187 and miRNA-143 in patients with gallbladder cancer.Methods A total of 92 patients with gallbladder cancer admitted to General Hospital of Northern Theater Command from September 2013 to March 2021 were selected as the gallbladder cancer group.In addition,80 patients with benign gallbladder disease treated at the same period were selected as the benign gallbladder disease group,and 80 healthy subjects at the same period were selected as the healthy control group.Serum of all subjects was collected,and serum levels of miRNA-187 and miRNA-143 were detected and compared.ROC curve was drawn to analyze the diagnostic efficacy of serum miRNA-187 and miRNA-143 levels in gallbladder cancer.The expressions of serum miRNA-187 and miRNA-143 in patients with gallbladder carcinoma with different clinical characteristics were compared.Results Serum miRNA-187 in gallbladder cancer group was higher than that in benign gallbladder disease group and healthy control group,while miRNA-143 was lower than that in benign gallbladder disease group and healthy control group,serum miRNA-187 in benign gallbladder disease group was higher than that in healthy control group,while miRNA-143 was lower than that in healthy control group,the differences were statistically significant (P<0.05).The AUC,sensitivity,specificity and Youden index of serum miRNA-187 combined with miRNA-143 in the diagnosis of gallbladder carcinoma were higher than those of the above two indexes alone.The expression level of miRNA-187 in serum of patients with TNM stage Ⅲto Ⅳ,poorly differentiated and lymph node metastasis was higher than that of patients with TNM stage Ⅰto Ⅱ,moderately well-differentiated and no lymph node metastasis,the differences were statistically significant (P<0.05).The expression level of miRNA-143 in serum of patients with TNM stageⅢto Ⅳ,poorly differentiated and lymph node metastasis gallbladder cancer was lower than that of patients with TNM stage Ⅰto Ⅱ,moderately well-differentiated and no lymph node metastasis gallbladder cancer,the differences were statistically significant (P<0.05).Conclusions Serum miRNA-187 is abnormally high in gallbladder cancer,while miRNA-143 is abnormally low.Combined detection may be helpful for clinical diagnosis and disease evaluation of gallbladder cancer. 2022 Vol. 29 (14): 96-99 [Abstract] ( 28 ) HTML (1 KB)  PDF (510 KB)  ( 28 ) 100 Effect of massage along the meridian combined with routine rehabilitation in the treatment of neurobehavioral disorder in neonates with hypoxic-ischemic encephalopathy WANG Hui；WANG Ziyang；LIAO Xuelin；LIU Yanrong；BAI Gang Objective To investigate the effect of massage along the meridian combined with conventional rehabilitation in the treatment of neurobehavioral disorder in neonates with hypoxic-ischemic encephalopathy (HIE).Methods From May 2019 to May 2021,72 children with HIE admiteed to the Department of Neonatology of Jingmen Hospital of Traditional Chinese Medicine were selected as the research subjects.They were divided into the treatment group (36 cases)and the control group (36 cases) according to random number table method.The children in the control group were treated with routine rehabilitation treatment,and the children in the treatment group were treated with massage along the meridian combined with routine rehabilitation.The 20 items of neonatal behavioral neurological assessment(NBNA),psychomotor development index (PDI),and mental development index (MDI) were compared between the two groups.Results The NBNA score of the children in the treatment group at the 21st day after treatment was higher than that in the control group,and the difference was statistically significant (P＜0.05).The PDI and MDI score of the children in the treatment group after 3 months and 6 months were higher than those in the control group,with statistical significances (P＜0.05).Conclusion The combination of massage along the meridian and conventional rehabilitation training can effectively improve the neurobehavioral disorder in children with HIE. 2022 Vol. 29 (14): 100-103 [Abstract] ( 28 ) HTML (1 KB)  PDF (598 KB)  ( 33 ) 104 Clinical effect of Chuanbai Zhiyang Lotion in the adjuvant treatment of vulvovaginitis in children ZHANG Dongguang；YI Pengfei；YANG Yu；ZOU Haiying；YANG Li；XIE Liling；XIONG Ting Objective To investigate the effect of adjuvant treatment with Chuanbai Zhiyang lotion in children with vulvovaginitis.Methods A total of 100 children with vulvovaginitis diagnosed and treated in Jiangxi Provincial Children′s Hospital from June to November 2021 were selected as research subjects,the patients were divided into the control group and the observation group according to random number table method,with 50 children in each group.The control group was treated with routine regimen,and the observation group was treated with Chuanbai Zhiyang Lotion on the basis of the control group.The clinical effects,the incidence of adverse drug reactions,medication adherence scores,the improvement time of clinical symptoms (pain,itching,purulent discharge) were compared between the two groups.Results The clinical total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant (P＜0.05).There was no significant difference in the incidence of adverse drug reactions between the two groups (P＞0.05).The score of medication compliance in the observation group was higher than that in the control group,and the difference was statistically significant (P＜0.05).The improvement time of pain,pruritus and purulent secretion in the observation group were shorter than those in the control group,and the differences were statistically significant (P＜0.05).Conclusion In the treatment of vulvovaginitis in children,the combination of Chuanbai Zhiyang Lotion can improve the treatment efficacy,with a rapid onset of action,and children′s medication adherence and safety are high,which is worth promoting. 2022 Vol. 29 (14): 104-106 [Abstract] ( 33 ) HTML (1 KB)  PDF (589 KB)  ( 84 ) 107 Value of continuous use of Aspirin during perioperative period of gynecological single hole laparoscopic surgery XU Baolin；PENG Lanlan；WANG Xiaohui Objective To explore the value of continuous use of Aspirin during perioperative period of gynecological single hole laparoscopy.Methods A total of 100 patients with benign gynecological diseases who underwent single hole laparoscopic surgery in Jingdezhen Second People′s Hospital from July 2019 to July 2021 were selected and divided into group A and group B according to random number table method,with 50 cases in each group.Group A continued to take Aspirin,oral from the morning,100 mg/time,once a day.Group B stopped Aspirin at 5-7 days before operation,resumed Aspirin at 3 days after operation,took it orally in the morning,100 mg/time,once a day.All patients were followed up to 30 days after operation.The perioperative coagulation function,operation condition and the incidence of adverse cardiovascular events in the two groups were compared and analyzed.Results There was no significant difference in the levels of platelet count (PLT),prothrombin time (PT),thrombin time (TT),plasma fibrinogen (FIB),coagulation reaction time (R) and blood coagulation time (K) in the two groups between the first day before operation and the first day after operation (P＞0.05).There was no significant difference in the operation time,intraoperative bleeding and 24 h hemoglobin reduction between the two groups (P＞0.05).After 30 days of follow-up,the incidence of cardiovascular adverse events in group A was lower than that in group B,the difference was statistically significant (P＜0.05).Conclusion The continuous use of Aspirin during the perioperative period of gynecological single hole laparoscopic surgery can effectively reduce the incidence of adverse cardiovascular events,and will not increase the risk of intraoperative bleeding,so as to better ensure the safety of patients. 2022 Vol. 29 (14): 107-109-114 [Abstract] ( 27 ) HTML (1 KB)  PDF (613 KB)  ( 76 ) 110 Analysis of clinical characteristics and risk factors of neonatal acute respiratory distress syndrome based on the “Montreux Standard” XU Hui；LIU Xuan；PAN Zhaojun；WU Rong Objective To analyze the clinical features and risk factors of neonatal acute respiratory distress syndrome(ARDS)based on the “Montreux Standard”.Methods The total number of newborns hospitalized at Huai′an Maternal and Child Health Center affiliated to Yangzhou University Medical College from January to December 2019 was 3930,of which 964 newborns with dyspnea symptoms were selected as subjects.According to “Montreux standard”,they were divided into the ARDS group (204 cases) and the non ARDS group (760 cases).The etiology,clinical characteristics and risk factors of ARDS were analyzed.Results In 2019,children with dyspnea symptoms in our hospital accounted for 24.5% (964/3930) of the newborns admitted in the same period,and children with ARDS accounted for 5.2% (204/3930) of the newborns admitted in the same period,and which were 76 cases(37.3%)with mild ARDS,69 cases(33.8%)with moderate ARDS,and 59 cases (28.9%) with severe ARDS.The gestational age and birth weight of neonates in the ARDS group were lower than those in the non-ARDS group,and the differences were statistically significant (P＜0.05).Neonatal asphyxia,pregnancy complications,infection,surgery,Downes score,oxygenation index (OI),mechanical ventilation,assisted ventilation time,use of alveolar surfactant (PS),use of nitric oxide (NO),complications in the ARDS group were all higher than those in the non-ARDS group,and the differences were statistically significant (P＜0.05).Multivariate Logistic regression analysis showed that infection,asphyxia,surgery,PS deficiency and high Downes score were risk factors for ARDS (P＜0.05).Conclusion The main causes of neonatal ARDS are infection,asphyxia,surgery,meconium and milk inhalation.Infection,asphyxia,surgery,PS deficiency and high Downes score are risk factors for ARDS. 2022 Vol. 29 (14): 110-114 [Abstract] ( 32 ) HTML (1 KB)  PDF (641 KB)  ( 38 ) 115 Effect of Montelukast Sodium Chewable Tablets and Loratadine Tablets combined with Triamcinolone Acetonide Nasal Spray in the treatment of allergic rhinitis in children LU Xiaoyan；LU Zhensheng；XIE Jiqing；ZHANG Liang Objective To investigate the clinical effect of the medication regimen of Montelukast Sodium Chewable Tablets and Loratadine Tablets combined with Triamcinolone Acetonide Nasal Spray in the treatment of allergic rhinitis in children,and to provide reference for pediatricians to choose reasonable treatment plan.Methods A total of 84 children with allergic rhinitis treated in the Rehabilitation Hospital of Guangzhou Social Welfare Hospital from January 2017 to December 2020 were selected as the study objects,and they were divided into the observation group (42 cases)and the control group (42 cases) according to the random number table method.The control group was treated with Loratadine Tablets combined with Triamcinolone Acetonide Nasal Spray,and the observation group was treated with Montelukast Sodium Chewable Tablets,Loratadine Tablets combined with Triamcinolone Acetonide Nasal Spray.The therapeutic effects of the two groups were analyzed and compared.Results There was no significant difference in the scores of nasal itching,sneezing,runny nose and nasal congestion between the two groups before treatment (P＞0.05).The scores of nasal itching,sneezing,runny nose and nasal congestion in the two groups after treatment were lower than those before treatment,and the differences were statistically significant (P＜0.05).The scores of the nasal itching,sneezing,runny nose and nasal congestion in the observation group were lower than those in the control group,and the differences were statistically significant (P＜0.05).The total effective rate of the observation group was 95.24%,which was higher than 76.19% of the control group,and the difference was statistically significant (P＜0.05).Conclusion The treatment effect of Montelukast Sodium Chewable Tablets and Loratadine Tablets combined with Triamcinolone Acetonide Nasal Spray is better than that of Loratadine Tablets combined with Triamcinolone Acetonide Nasal Spray.The combination of the three drugs achieve remarkable clinical efficacy,and good safety,which is worthy of clinical promotion and application. 2022 Vol. 29 (14): 115-118 [Abstract] ( 32 ) HTML (1 KB)  PDF (599 KB)  ( 104 ) 119 Clinical effect of Mifepristone combined with Methotrexate in the treatment of ectopic pregnancy TANG Shuqiong Objective To investigate the clinical effect of Mifepristone combined with Methotrexate in the treatment of ectopic pregnancy.Methods A total of 160 patients with ectopic pregnancy treated in Luzhou Hospital of Traditional Chinese Medicine from March 2019 to March 2021 were selected and divided into the control group (80 cases) and the observation group(80 cases) according to random number table method.The control group was treated with Methotrexate,and the observation group was treated with Mifepristone on the basis of the control group.Both groups were treated for 1 week and followed up for 1 month.The clinical related indexes,marriage quality,and serum human chorionic gonadotropin (β-HCG),progesterone (P),estradiol (E2),luteinizing hormone (LH),follicle stimulating hormone (FSH)levels and package diameter before and after treatment between the two groups were compared.Results The disappearance time of symptoms,blood β-HCG return to normal time,the negative conversion time of β-HCG,the disappearance time of pelvic mass and the length of hospital stay in the observation group were shorter than those in the control group,the differences were statistically significant (P＜0.05).The levels of serum β-HCG,P of the two groups after treatment were all lower than those before treatment,and the diameter of the package of the two groups after treatment was smaller than that before treatment,the differences were statistically significant (P＜0.05).The levels of serum β-HCG,P of the observation group after treatment were all lower than those of the control group,and the diameter of the package of the observation group after treatment was smaller than that of the control group,the differences were statistically significant (P＜0.05).After treatment,the serum E2 level in the control group was lower than before treatment,the serum E2 level in the observation group was higher than before treatment,and the observation group was higher than the control group,the differences were statistically significant (P＜0.05).There was no significant difference in the levels of LH and FSH between the two groups before and after treatment (P＞0.05).There was no significant difference in the levels of LH and FSH between the two groups after treatment (P＞0.05).The scores of marriage quality related indicators(amateur activities,relationship with relatives and friends,belief consistency,children and marriage) of the two groups after treatment were higher than those before treatment,the differences were statistically significant (P＜0.05).The scores of marriage quality related indicators (amateur activities,relationship with relatives and friends,belief consistency,children and marriage) in the observation group were higher than those in the control group,the differences were statistically significant (P＜0.05).Conclusion Mifepristone combined with Methotrexate in the treatment of ectopic pregnancy can reduce the pelvic mass,promote the recovery of sexual hormone level,and improve the quality of marriage.The clinical effect is remarkable. 2022 Vol. 29 (14): 119-122 [Abstract] ( 30 ) HTML (1 KB)  PDF (597 KB)  ( 38 ) 123 Application of invisible orthodontic technique without bracket and straight wire fixed appliance in orthodontic patients and its effect on periodontal health CAO Shen；WANG Xin Objective To investigate the effect of invisible orthodontic technique without bracket and straight wire fixed appliance in orthodontic patients.Methods The clinical data of 92 orthodontic patients treated in the Affiliated Stomatological Hospital of Jiujiang University from May 2019 to may 2020 were analyzed retrospectively.They were divided into control group(46 cases)and observation group(46 cases)according to different correction methods.The control group was treated with straight wire arch fixed appliance,and the observation group was treated with invisible orthodontic technique without bracket until 6 months after treatment.The improvement of teeth,periodontal health,masticatory function,quality of life and complications were compared between the two groups.Results The observation group had shorter treatment time than the control group,the difference was statistically significant (P<0.05).There was no significant difference in periodontal health between the two groups before treatment (P>0.05).The plaque index (PLI),gingival sulcus probing depth (SPD),gingival index (GI) and gingival sulcus bleeding index (SBI) after treatment were higher than those before treatment,the differences were statistically significant (P<0.05).After treatment,PLI,SPD,GI and SBI in the observation group were lower than those in the control group,the differences were statistically significant (P<0.05).There were no significant difference in masticatory function and quality of life between the two groups before treatment (P>0.05).The masticatory efficiency,bite force and OHIP scores of the two groups after treatment were higher than those before treatment,the differences were statistically significant (P<0.05).The masticatory efficiency,bite force and OHIP score of the observation group were higher than those of the control group,the differences were statistically significant (P<0.05).The incidence of complications in the observation group was lower than that in the control group,the difference was statistically significant (P<0.05).Conclusion Invisible orthodontic treatment without brackets can shorten the correction time of inclined teeth and transposed teeth,reduce the damage to periodontal tissue,promote the recovery of masticatory function,reduce the impact of oral problems on quality of life,and have fewer complications. 2022 Vol. 29 (14): 123-126 [Abstract] ( 29 ) HTML (1 KB)  PDF (462 KB)  ( 53 ) 127 Effect of multi-target repetitive transcranial magnetic stimulation combined with acupuncture on subjective tinnitus in middle-aged and elderly patients SUN Guihu；LIU Xiaoyang；YANG Xingyu；ZHAO Zhanliang Objective To explore the clinical efficacy of multi-target repetitive transcranial magnetic stimulation(rTMS) combined with acupuncture in the treatment of subjective tinnitus in the elderly.Methods A total of 60 middle-aged and elderly patients with severe subjective tinnitus admitted to the Department of Otolaryngology of Dalian Third People′s Hospital from June 2020 to May 2021 were selected as the research objects.They were divided into multi-target magnetic stimulation group,single-target magnetic stimulation group and acupuncture group by random number table method,with 20 patients in each group.Patients in the multi-target magnetic stimulation treatment group were treated with multi-target magnetic stimulation plus acupuncture in bilateral temporal parietal cortex and the right dorsolateral prefrontal cortex,patients in the single-target magnetic stimulation treatment group were treated with magnetic stimulation plus acupuncture in bilateral temporal parietal cortex,patients in the acupuncture group were treated with single acupuncture.Tinnitus disability scale (THI),visual analogue scale (VAS) scores and adverse reactions were compared before and after treatment among the three groups.Results THI and VAS scores in the three groups after treatment were lower than before,the differences were statistically significant (P<0.05).Compared with before treatment,the THI and VAS scores in the three groups were decreased after treatment,the differences were statistically significant(P<0.05).After treatment,the THI and VAS scores of multi-target rTMS combined group were lower than those of rTMS group and acupuncture group ,the differences were statistically significant (P<0.05).There was no significant difference in the total incidence of adverse reactions between the three groups after treatment (P>0.05).Conclusion Multi-target repetitive transcranial magnetic stimulation combined with acupuncture has obvious therapeutic effect on middle-aged and elderly patients with moderate subjective tinnitus,which can more effectively reduce the severity of tinnitus and significantly improve the discomfort of patients. 2022 Vol. 29 (14): 127-130 [Abstract] ( 30 ) HTML (1 KB)  PDF (439 KB)  ( 65 ) 131 Application effect of Cefoperazone Sodium Sulbactam Sodium in elderly patients with cerebral infarction complicated with pulmonary infection CHEN Ning；CAO Xingyi Objective To investigate the application effect of Cefoperazone Sodium Sulbactam Sodium in elderly patients with cerebral infarction complicated with pulmonary infection.Methods A total of 57 elderly patients with cerebral infarction complicated with pulmonary infection in the Department of Pneumoconiosis of General Hospital of Xuzhou Mining Group from May 2019 to August 2020 were selected as the research objects,according to random number table method,they were divided into the control group (28 cases) and the observation group (29 cases).Both groups were given routine treatment,the control group was given Ceftazidime on the basis of conventional treatment,the observation group was given Cefoperazone Sodium Sulbactam Sodium on the basis of conventional treatment.The levels of blood gas index,immune function and inflammatory factor of the two groups before and after treatment were compared.Results Before treatment,there were no significant differences in the levels of hydrogen ion concentration index (pH),partial pressure of oxygen (PaO2),and partial pressure of carbon dioxide (PaCO2) between the two groups (P＞0.05).The levels of pH and PaO2 in the two groups after treatment were higher than those before treatment,and the levels of pH and PaO2 in the observation group after treatment were higher than those in the control group,and the differences were statistically significant (P＜0.05).The level of PaCO2 in the two groups after treatment was lower than that before treatment,and the level of PaCO2 in the observation group after treatment was lower than that in the control group,and the difference was statistically significant (P ＜0.05).There were no significant differences in the levels of serum immunoglobulin A (IGA),immunoglobulin G (IgG) and immunoglobulin M (IgM) between the two groups before treatment(P＞0.05).After treatment,the levels of serum IgA,IgG,and IgM in the two groups were higher than those before treatment,and the levels of serum IgA,IgG,and IgM in the observation group after treatment were higher than those in the control group,and the differences were statistically significant (P＜0.05).Before treatment,there were no statistical differences in the levels of serum interleukin-6 (IL-6),interleukin-8 (IL-8) and tumor necrosis factor-α (TNF-α) between the two groups (P＞0.05).After treatment,the levels of serum IL-6,IL-8 and TNF-α in the two groups were lower than those before treatment,and the levels of serum IL-6,IL-8 and TNF-α in the observation group after treatment were lower than those in the control group,the differences were statistically significant (P＜0.05).Conclusion Cefoperazone Sodium Sulbactam Sodium can effectively improve blood gas index,enhance immune ability and reduce inflammatory response in elderly patients with cerebral infarction complicated with pulmonary infection. 2022 Vol. 29 (14): 131-134 [Abstract] ( 25 ) HTML (1 KB)  PDF (403 KB)  ( 76 ) 135 Clinical effect of Ceftazidime combined with Levofloxacin in treatment of elderly patients with heart failure complicated with pulmonary infection LIU Yanjun；QI Liwen Objective To investigate the clinical effect of Ceftazidime combined with Levofloxacin in the treatment of elderly patients with heart failure complicated with pulmonary infection.Methods Seventy-six elderly patients with heart failure complicated with pulmonary infection who were admitted to Feicheng People′s Hospital from May 2019 to May 2020 were selected as subjects and divided into the observation group and the control group by the random number table method,with 38 patients in each group.All patients were treated with diuresis,cardiac strengthening,vasodilation and other conventional treatment.The control group was treated with Ceftazidime for injection.The observation group was treated with intravenous Levofloxacin on the basis of the control group.The levels of inflammatory factors in the two groups before and after treatment were compared,mainly including the levels of B-type natriuretic peptide(BNP),white blood cell (WBC),procalcitonin (PCT),interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α).Cardiac function indexes of the two groups were compared before and after treatment,and the changes of left ventricular diastolic diameter (LEVDD),left ventricular end systolic diameter (LVESD),left ventricular ejection fraction (LVEF)and end systolic left ventricular diameters (LVDs) were recorded.The clearance of pathogenic bacteria between the two groups was compared,and samples from the two groups were collected before and after treatment to detect the numbers of pathogenic bacteria.The therapeutic effect of the two groups were compared.Results There were no significant differences in the levels of IL-6,TNF-α,BNP,WBC and PCT between the two groups before treatment (P>0.05).The levels of IL-6,TNF-α,BNP,WBC and PCT in observation group were lower than those in control group after treatment,the differences were statistically significant (P<0.05).The levels of IL-6,TNF-α,BNP,WBC and PCT in the two groups after treatment were lower than the those before treatment,the differences were statistically significant (P<0.05).There were no significant differences in cardiac function indexes between the two groups before treatment (P>0.05).After treatment,LVESD,LEVDD and LVDs in the observation group were lower than those in the control group,and the differences were statistically significant (P<0.05).The LVEF of the observation group was higher than that of the control group after treatment,and the difference was statistically significant (P<0.05).The LVESD,LEVDD and LVDs in the two groups after treatment were lower than those before treatment,and the differences were statistically significant (P<0.05).The LVEF levels of the two groups after treatment were higher than those before treatment,and the differences were statistically significant (P<0.05).The clearance rate of pathogenic bacteria in the observation group was higher than that in the control group after treatment,and the difference was statistically significant (P<0.05).The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).Conclusion Ceftazidime combined with Levofloxacin in the treatment of senile heart failure complicated with pulmonary infection has a good therapeutic effect,which has the significance of clinical promotion. 2022 Vol. 29 (14): 135-139 [Abstract] ( 25 ) HTML (1 KB)  PDF (408 KB)  ( 14 ) 140 Analysis of the influencing factors of premature cerebral infarction LIN Yufeng；HUANG Xinghong；CHEN Dongling；LI Yangyang；XU Qiugui Objective To explore the influencing factors of premature cerebral infarction.Methods The clinical data of 106 patients with acute cerebral infarction treated in Yangjiang People′s Hospital from July 2019 to July 2021 were analyzed retrospectively,they were divided into premature cerebral infarction group (n=49) and non premature cerebral infarction group (n=57) according to the age of onset.The clinical data and familial hypercholesterolemia (FH) and blood lipid indexes of the two groups were compared,and multivariate logistic regression analysis was used for premature cerebral infarction.Results The prevalence of FH in premature cerebral infarction group was higher than that in non premature cerebral infarction group,the difference was statistically significant (P<0.05).The multivariate logistic regression analysis showed that history of stroke (OR=1.92,95%CI:1.84-3.29),history of hypertension (OR=1.38,95%CI:1.84-1.69),triglyceride (TG) (OR=1.83,95%CI:1.36-4.89),low density lipoprotein cholesterol (LDL-C) (OR=1.79,95%CI:1.34-4.39) and FH (OR=1.98,95%CI:1.70-3.61) are the independent risk factors of premature cerebral infarction.Conclusion FH and blood lipid indexes are independent risk factors of premature cerebral infarction.Clinically,we can prevent premature cerebral infarction by diagnosing FH and controlling blood lipid level. 2022 Vol. 29 (14): 140-142 [Abstract] ( 27 ) HTML (1 KB)  PDF (523 KB)  ( 40 ) 143 Application of analytical batch length Westgard sigma rule in enzymological laboratory internal quality control SONG Yuyin Objective Using the Westgard sigma (σ) rule of analytical batch length to set up a reasonable quality control strategy for the indoor quality control of enzymology.Methods Data of Panjin Liaoyou Baoshihua Hospital participating in the national laboratory quality evaluation center in 2020 and data of laboratory indoor quality control were collected as bias and coefficient of variation.The allowed total error provided by the Quality Index of Routine Item Analysis of Clinical Biochemical Tests issued by the National Health Commission (health industry standard WS/T403-2012) was used as the criterion to calculate the σ measure,select the quality control strategy according to the Westgard σ rule of analytical batch length,calculate the quality objective index,and evaluate the analytical performance of enzymology.Results Among all enzymology items,2 items had a σ≥6;the 13s rule was selected,and the analytical batch length was 1000.The σ levels of 2 items were 6＞σ≥5;the quality control rule was 13s/22s/R4s,and the quality control was conducted every 450 tests.The σ levels of 2 items were 5＞σ≥4;the quality control rule was 13s/22s/R4s/41s,and the quality control was conducted every 200 tests.The σ level of 1 item was 4＞σ≥3;the quality control rule was 13s/22s/R4s/41s/6x,and the quality control was conducted every 45 tests.Conclusion The analytical batch length Westgard σ rule is a patient-risk-based quality control strategy that optimizes quality control strategies,improves quality programs,and improves laboratory testing capabilities. 2022 Vol. 29 (14): 143-145-149 [Abstract] ( 31 ) HTML (1 KB)  PDF (644 KB)  ( 30 ) 146 Diagnostic value of GeneXpert Mycobacterium tuberculosis/Rifampin technology and acid-fast staining in pulmonary tuberculosis LI Xingmin Objective To evaluate and analyze the diagnostic value of GeneXpert Mycobacterium tuberculosis/Rifampin(GeneXpert MTB/RIF) technology and acid-fast staining in the diagnosis of tuberculosis.Methods A total of 80 patients with suspected tuberculosis admitted to the Sino-Singapore Guangzhou Knowledge City Hospital from October 2019 to October 2021 were selected as the research objects.GeneXpert MTB/RIF technology,acid-fast staining were used for detection,and clinical pathological diagnosis was the gold standard.Compare the positive rate and diagnostic efficiency of the two methods.Results A total of 42 cases of 80 suspected tuberculosis patients were diagnosed by clinical pathology.The positive rate of GeneXpert MTB/RIFF technology was higher than that of acid-fast staining.The diagnostic sensitivity,specificity,and accuracy of GeneXpert MTB/RIF technology are 90.48%,100.00% and 95.00%,respectively.The diagnostic sensitivity,specificity,and accuracy of acid-fast staining are 33.33%,100.00% and 65.00%,respectively.The diagnostic sensitivity and accuracy of GeneXpert MTB/RIF technology were higher than those of acid-fast staining,and the differences were statistically significant (P＜0.05).Conclusion The application of GeneXpert MTB/RIF technology in the diagnosis of tuberculosis has significant diagnostic value,greatly improving the sensitivity and specificity of the detection of Mycobacterium tuberculosis and Rifampicin resistance,and providing an effective reference for the development of clinical disease diagnosis and treatment activities. 2022 Vol. 29 (14): 146-149 [Abstract] ( 25 ) HTML (1 KB)  PDF (520 KB)  ( 35 ) 150 Significance of interleukin-6 and high-sensitivity C-reactive protein levels in evaluating the severity and prognosis of mycoplasma pneumonia XIANG Tianhe Objective To investigate the significance of serum interleukin-6 (Interleukin,IL-6) and high-sensitivity C-reactive protein (hypersensitive C-reactive protein,hs-CRP) in the prognosis of mycoplasma pneumonia.Methods A total of 400 children with mycoplasma pneumonia treated in Jianli Hospital of Traditional Chinese Medicine from December 2019 to December 2020 were selected as the research subjects,and they were divided into severe group and non-severe group according to disease severity,with 200 cases in each group.Another 180 healthy subjects were selected as the control group.The serum IL-6 and hs-CRP levels of the three groups were compared.Children with pneumonia were divided into good prognosis group and poor prognosis group according to their prognosis.Serum IL-6 and hs-CRP levels of children with different prognosis were compared,and the correlation between serum IL-6 and hs-CRP levels and disease severity was compared.Receiver operating characteristic (ROC) curve was used to analyze the diagnostic efficacy of single and combined IL-6 and hs-CRP for disease prognosis.Results The levels of serum IL-6 and hs-CRP in severe group were higher than those in non-severe group and control group,and the levels of serum IL-6 and hs-CRP in non-severe group were higher than those in control group,the differences were statistically significant (P<0.05).Serum IL-6 and hs-CRP levels in the poor prognosis group were higher than those in the good prognosis group,the differences were statistically significant (P<0.05).Serum IL-6 and hs-CRP levels were positively correlated with the severity of mycoplasma pneumonia (P<0.05).ROC curve results showed that the areas under the curve of serum IL-6 and hs-CRP for diagnosis of mycoplasma pneumonia were 68.6,76.1 and 91.4 respectively,with 95% confidence intervals of 61.0-76.1,69.6-82.7 and 87.3-95.5,respectively.The diagnostic efficiency of serum IL-6 and hs-CRP combined detection was higher than that of single detection.Conclusion Serum IL-6 and hs-CRP are involved in the occurrence and development of mycoplasma pneumonia.The higher the level of serum IL-6 and hs-CRP is,the more serious the disease is.The combined detection of the two is helpful to determine the severity of mycoplasma pneumonia and improve the prognostic value. 2022 Vol. 29 (14): 150-153 [Abstract] ( 29 ) HTML (1 KB)  PDF (543 KB)  ( 45 ) 154 Investigation on the current situation of myopia and influencing factors among middle school students in Guilin JIN He；YANG Yingqin；JIANG Dongdong；FAN Jing；DING Zhixiang；LU Suqing；YANG Binbin；ZHENG Liu Objective To analyze the prevalence of myopia and its influencing factors among middle school students in Guilin.Methods From September 2021 to October 2021,2223 senior high school students aged 15-18 in Guilin were selected by stratified sampling method as the research objects.According to whether they had myopia,they were divided into the myopic group (1431 cases) and the non-myopic group (792 cases).Logistics regression analysis was used to analyze the related factors of myopia.Results The prevalence of myopia among senior high school students was 64.37%,and univariate analysis showed that Myopia and myopic group of gender,parents myopia,homework time,outdoor activities,the use of electronic products,the average sleep time,whether to have eyesight protection habits,often stay up late,often rub eyes,picky about food and sweet food,like to read in the sun and the car such as comparison,the difference was statistically significant (P<0.05).Multivariate analysis showed that female,parents with myopia,longer homework time and longer use of electronic devices were independent risk factors for myopia (β＞0, OR＞1, P<0.05).Conclusion The prevalence rate of myopia among high school students in Guilin is relatively high.It is necessary to strengthen the propaganda and education of myopia prevention and control,and urge students to form a good and correct habit of using eyes. 2022 Vol. 29 (14): 154-158 [Abstract] ( 25 ) HTML (1 KB)  PDF (479 KB)  ( 108 ) 159 Correlation research between blood oxygen saturation,quality of life and fatigue in patients with stable chronic obstructive pulmonary disease KOU Xuemei；LI Xinxia Objective To investigate the relationship between fatigue and blood oxygen saturation,COPD assessment questionnaire (CAT) score in stable chronic obstructive pulmonary disease (COPD) patients.Methods A total of 240 stable COPD patients treated in The Affiliated Hospital of Inner Mongolia Medical University from February to August 2021 were selected as the research objects.Blood oxygen saturation and CAT and multidimensional fatigue inventory(MFI-20) scores of the patients were investigated. Pearson correlation analysis was used to analyze the correlation between blood oxygen saturation and CAT score and fatigue.Results The total fatigue score of stable COPD patients was (65.65±12.23) points,and the scores of physical fatigue,mental fatigue,motivation decline and activity reduction were (35.84±7.07),(9.64±2.67),(10.38±1.97) and (9.80±2.45) points respectively.There was a negative correlation between blood oxygen saturation and MFI-20 score and dimensions score,and a positive correlation between total CAT score and MFI-20 score and dimensions score (P<0.05).Conclusion Oxygen saturation index and quality of life are significantly correlated with fatigue degree in stable COPD patients.Medical workers can alleviate fatigue of patients by improving hypoxia symptoms and quality of life. 2022 Vol. 29 (14): 159-162 [Abstract] ( 28 ) HTML (1 KB)  PDF (511 KB)  ( 26 ) 163 Common questions and analysis of drug consultation in outpatient pharmacy YIN Wenjing；SU Kejian；LU Guohong Objective The data of drug consultation in outpatient drug consultation room of South Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine were analyzed and summarized to improve the level of pharmaceutical care,improve the quality of drug consultation service and promote rational drug use.Methods The data of 5110 cases of professional pharmaceutical consultation in outpatient drug consultation room from January to December 2020 were classified and statistically analyzed,and the main factors and secondary factors were analyzed by using Pareto diagram.Results Among 5110 cases of professional pharmaceutical consultation,there were more women than men,and there were 3007 cases of women,accounting for 58.85%.There were 2103 male cases,accounting for 41.15%.4794 cases were mainly consulted by patients and their families,accounting for 93.82%.Among them,middle-aged and elderly patients (40-70 years old) were consulted more,3585 cases,accounting for 70.16%.Professional pharmaceutical problems were divided into 10 types of data,the main factors were found to be usage and dosage,precautions,adverse reactions,medication guidance for special devices,drug interaction,etc.,and the accumulative component ratio ranged from 0-80%.Among the 13 types of drugs consulted,drugs of cardiovascular system,digestive system,respiratory system,nervous system,anti-infective system and endocrine system were the main factors,and the accumulative composition ratio ranged from 0-80%.Conclusion According to the analysis of the main and minor problems of the content and type of consultation,consulting pharmacists can improve the level of pharmaceutical care and promote rational drug use. 2022 Vol. 29 (14): 163-166-174 [Abstract] ( 28 ) HTML (1 KB)  PDF (1110 KB)  ( 26 ) 167 Application effect of rehabilitation nursing on schizophrenic patients with auditory hallucination LIANG Xiaoli；LI Meizhi；ZHOU Zhiqiang Objective To explore the application effect of rehabilitation nursing in patients with schizophrenia auditory hallucination.Methods A total of 160 patients with schizophrenia and auditory hallucinations admitted to the Hu′nan Brain Hospital from January 2017 to October 2018 were selected and divided into control group (80 cases) and experimental group (80 cases),the control group was given routine care of schizophrenia,the experimental group was given rehabilitation care.The days of hospitalization,treatment costs and times of hospitalization were compared between the two groups.Positive and negative symptom scale (PANSS) and self-awareness and treatment attitude questionnaire score (ITAQ) were used to evaluate the efficacy.Results The number of hospitalization days,treatment costs and hospitalization times in the experimental group were all less than those in the control group after intervention,the differences were statistically significant (P<0.05).There were no significant differences in positive symptoms,negative symptoms,general symptoms and total PANSS scores of the two groups after intervention (P>0.05).After intervention,the score of auditory hallucinations in experimental group was lower than that in control group,and the score of ITAQ scale was higher than that in control group,the differences were statistically significant (P<0.05).There was no significant difference in the total effective rate between the two groups after intervention (P>0.05).Conclusion Although rehabilitation nursing has no obvious improvement on the symptoms of schizophrenic patients with auditory hallucination,but it can significantly improve the insight of patients,significantly shorten the hospitalization days,treatment expenses and hospitalization times,which has good economic benefits and is worthy of further promotion. 2022 Vol. 29 (14): 167-170-178 [Abstract] ( 33 ) HTML (1 KB)  PDF (679 KB)  ( 219 ) 171 Application effect of early warning nursing combined with airway nursing in children with mycoplasma pneumonia CHENG Jun；JIANG Yunxiu；YANG Shizhan Objective To explore the effect of early warning nursing combined with airway nursing in children with mycoplasma pneumonia.Methods From January 2019 to March 2020,102 children with mycoplasma pneumonia admitted to the Department of Pediatrics and Respiratory Medicine,Xiaolan People′s Hospital,Zhongshan City,Guangdong Province were selected as the research objects,and they were divided into the control group (51 cases) and the observation group (51 cases) by random number table method.The control group used airway nursing intervention,and the observation group used early warning nursing combined with airway nursing.Both groups intervened for 1 week.The time of clinical symptom relief,the occurrence of complications,and the nursing satisfaction of the parents of the two groups of children during the nursing period were compared.Results The time to relieve symptoms of cough,fever,and dyspnea during the intervention of the observation group was shorter than that of the control group,and the difference was statistically significant (P<0.05).The incidence of complications during the intervention period of the observation group was lower than that of the control group,and the difference was statistically significant (P<0.05).The care satisfaction degree of parents of children in the observation group was higher than that of the control group 1 week after intervention,and the difference was statistically significant (P<0.05).Conclusion Early warning nursing combined with airway nursing can shorten the remission time of clinical symptoms in children with mycoplasma pneumonia,reduce the occurrence of complications,and the parents of the children have higher nursing satisfaction. 2022 Vol. 29 (14): 171-174 [Abstract] ( 27 ) HTML (1 KB)  PDF (652 KB)  ( 24 ) 175 Application of rectal myoelectricity biofeedback system combined with rectal function training in neurogenic rectum ZHU Wei；MEI Xinlian；ZOU Jing Objective To explore the application value of rectal myoelectricity biofeedback system combined with rectal function training in neurogenic rectum.Methods A total of 60 patients with neurogenic rectum admitted to Jiujiang First People′s Hospital from June 2020 to October 2021 were selected as the research objects.According to random number table method,they were divided into observation group (n=30) and control group (n=30).The control group was given traditional rectal function training,while observation group was intervened with rectal myoelectricity biofeedback system on basis of control group.The classifications of stool symptoms after intervention,the score of neurogenic bowel dysfunction (NBD) and Barthel score before and 1 month after intervention,and the score of nursing satisfaction after intervention were compared between the two groups.Results After intervention,classifications of stool symptoms in observation group were better than those in control group,and type Ⅳstool was more than that in control group,and the differences were statistically significant (P<0.05).After intervention,NBD of the two groups was lower than before intervention,and Barthel score was higher than before intervention and NBD score of the observation group was lower than that of the control group,and Barthel score of the observation group was higher than that of the control group,with statistical significances (P<0.05).After intervention,the scores of patients satisfaction with nursing staffs′ nursing quality (theoretical knowledge level,nursing work attitude,safety management of nursing staffs,nursing error behaviors,writing quality of nursing document) in observation group were higher than those in control group,with statistical significances (P<0.05).Conclusion Rectal myoelectricity biofeedback system combined with rectal function training can better recover defecation function and improve prognosis of patients with neurogenic rectum. 2022 Vol. 29 (14): 175-178 [Abstract] ( 27 ) HTML (1 KB)  PDF (624 KB)  ( 54 ) 179 Impact of the "Internet"based home health continuation care model on the prognosis of stroke patients LI Yanfeng；CHI Yue；YANG Zhong Objective To explore the effect of home health continuity nursing mode based on "Internet"on the prognosis of stroke patients.Methods Clinical data of 80 stroke patients admitted to Longhua District People′s Hospital of Shenzhen City from October 2019 to June,2020 were retrospectively analyzed,and they were divided into control group(40 cases) and experimental group (40 cases) according to nursing methods.The control group adopted routine nursing,and the experimental group adopted home health continuing nursing based on "Internet".The nursing compliance rate,modified Rankin scale (mRS),daily self-care ability score (ADL),readmission rate,disease recurrence rate and mortality were compared between the two groups.Results The excellent and good rate of nursing compliance in experimental group was higher than that in control group,the difference was statistically significant (P<0.05).After nursing,the mRS frequency of the two groups was lower than those before nursing,and the ADL score was higher than those before nursing,and the mRS score of experimental group was lower than that in the control group,and the ADL score was higher than that in the control group,the differences were statistically significant (P<0.05).The readmission rate,relapse rate and mortality rate of the experimental group were lower than those of the control group during the follow-up period,the differences were statistically significant (P<0.05).Conclusion Based on the "Internet"home health continuing care model can improve the nursing compliance of stroke patients after discharge,improve patients′ self-care ability and quality,and effectively reduce their risk of readmission,relapse and death.This nursing model has high clinical application and promotion value. 2022 Vol. 29 (14): 179-182 [Abstract] ( 30 ) HTML (1 KB)  PDF (651 KB)  ( 36 ) 183 Effect of continuous nursing based on the theory of knowledge,belief,behavior and intervention on the level of hope and quality of life of patients with primary liver cancer LIU Bingyao Objective To explore the impact of continual nursing based on the theory of knowledge,attitude,belief,practice (KAP) on the level of hope and quality of life of patients with primary liver cancer interventional therapy.Methods A total of 279 patients with primary liver cancer who received interventional treatment from January 2019 to December 2020 in the First People′s Hospital of Zhaoqing City were selected as research objects,they were divided into research group (n=140) and control group (n=139) according to random number table method,the control group carried out routine nursing during the treatment process,and the research group carried out continuous nursing based on KAP theory,compare hope level,self-efficacy,nursing compliance rate and quality of life of two groups before and after nursing.Results The Herth hope scale (HHI),general self-efficacy scale (GSES) scores,nursing excellence rate,ability of daily living scale (ADL) and health-related quality of life scale (HRQOL) scores after nursing in the research group were all higher than those in the control group,and the differences were statistically significant (P<0.05).Conclusion The implementation of continuation care based on KAP theory in the interventional treatment of patients with primary liver cancer can significantly increase the level of hope and self-efficacy of the patients.Under this care plan,patients have higher compliance and higher quality of life after care.Its clinical significance is great,and it is recommended to be further promoted. 2022 Vol. 29 (14): 183-185-189 [Abstract] ( 29 ) HTML (1 KB)  PDF (1053 KB)  ( 35 ) 186 Effect of prenatal breast acupuncture massage combined with traditional Chinese medical emotional nursing on breastfeeding after the first cesarean section YANG Qiongxin；JIN Zhidao；AO Jinsong Objective To explore the effect of antenatal breast acupuncture massage combined with traditional Chinese medical emotional nursing on breastfeeding after the first cesarean section.Methods A total of 97 women after cesarean section treated in the Department of Obstetrics of Maternal and Child Health Hospital of Jiangxia District from January 2020 to January 2021 were selected and numbered according to the order of medical treatment,they were divided into observation group (n=49) and control group (n=48) according to random number table method.The control group received routine postpartum nursing,while the observation group received prenatal breast acupoint massage combined with traditional Chinese medical emotional nursing on the basis of postpartum routine nursing.The degree of postpartum breast filling,lactation time and 48 h postpartum lactation volume were compared between the two groups,the intervention effects of the two groups were compared.Results The degree of breast fullness in observation group after intervention was higher than that in control group,and the difference was statistically significant (P<0.05).The lactation time of observation group after intervention was shorter than that of control group,and the lactation amount of observation group after intervention was higher than that of control group,the differences were statistically significant (P<0.05).The excellent and good rate of observation group after intervention was higher than that of control group,and the difference was statistically significant (P<0.05).Conclusion Prenatal breast acupuncture massage combined with emotional nursing can increase postpartum lactation,shorten lactation time,and increase maternal breast fullness after the first cesarean section. 2022 Vol. 29 (14): 186-189 [Abstract] ( 27 ) HTML (1 KB)  PDF (626 KB)  ( 35 ) 190 Application effect of high-quality nursing in perioperative period of patients with cholecystitis HU Xue；LI Jing；LIU Lin；QU Ying；ZHAO Xue▲ Objective To explore the application effect of high-quality nursing in patients with cholecystitis surgery.Methods A total of 86 patients with cholecystitis admitted to the Second Department of General Surgery of Hongqi Hospital Affiliated to Mudanjiang Medical University from July 2019 to July 2020 were selected as the research objects.According to different nursing methods,they were divided into two groups,with 43 cases in each group.The patients in the reference group received routine care,and the patients in the study group received high-quality care.The excellent and good rate of cognition on cholecystitis surgery,Hamilton anxiety scale (HAMA) score,total incidence of postoperative complications and total satisfaction rate of perioperative nursing service were compared between the two groups.Results The excellent and good rate of cognition on cholecystitis surgery and total satisfaction rate of perioperative nursing service in the study group were higher than those in the reference group,with statistical significances (P<0.05).After nursing,HAMA scores of the two groups was lower than those before nursing,the differences were statistically significant (P<0.05).After nursing,HAMA score of the study group was lower than that of the reference group,the difference was statistically significant (P<0.05).The total incidence of postoperative complications of the study group was lower than that of the reference group,the difference was statistically significant (P<0.05).Conclusion Patients with cholecystitis surgery have better effect on receiving high-quality care,which is helpful to improve the level of surgical cognition,reduce anxiety as well as the total incidence of postoperative complications,and have a high satisfaction rate for examination services. 2022 Vol. 29 (14): 190-192-196 [Abstract] ( 25 ) HTML (1 KB)  PDF (665 KB)  ( 32 ) 193 Application of comprehensive nursing intervention in children undergoing disposable circumcision CHENG Qing Objective To analyze the application effect of comprehensive nursing intervention in children undergoing disposable circumcision.Methods A total of 98 children who were treated with disposable circumcision device in Fujian Maternal and Child Health Hospital from May 2020 to May 2021 were selected as the research subjects.They were divided into conventional group and study group by random number table method,with 49 cases in each group.The routine group used postoperative general nursing,the study group used postoperative comprehensive nursing intervention.The negative emotion scores (children depression rating scale[CDRS],children anxiety disorder screening scale[SCARED]),pain indicators (visual analog scale[VAS]),the total incidence of postoperative complications,and total nursing satisfaction of the two groups were compared.Results The CDRS score and SCARED score of the study group were lower than those of the conventional group after intervention,and the differences were statistically significant (P<0.05).VAS scores of 2,12 and 24 h after operation in the study group were lower than those in the conventional group,the differences were statistically significant (P<0.05).The total incidence of postoperative complications in the study group was lower than that in the conventional group,and the difference was statistically significant (P<0.05).The total nursing satisfaction of the study group was higher than that of the conventional group,and the difference was statistically significant (P<0.05).Conclusion Comprehensive nursing intervention after pediatric circumcision can further reduce the negative emotions and pain of children,promote them to actively cooperate with the treatment,actively avoid complications,so as to obtain a more satisfactory clinical outcome. 2022 Vol. 29 (14): 193-196 [Abstract] ( 25 ) HTML (1 KB)  PDF (625 KB)  ( 45 )

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