头孢哌酮钠舒巴坦钠在老年脑梗死合并肺部感染患者中的应用效果

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Abstract Objective To investigate the application effect of Cefoperazone Sodium Sulbactam Sodium in elderly patients with cerebral infarction complicated with pulmonary infection.Methods A total of 57 elderly patients with cerebral infarction complicated with pulmonary infection in the Department of Pneumoconiosis of General Hospital of Xuzhou Mining Group from May 2019 to August 2020 were selected as the research objects,according to random number table method,they were divided into the control group (28 cases) and the observation group (29 cases).Both groups were given routine treatment,the control group was given Ceftazidime on the basis of conventional treatment,the observation group was given Cefoperazone Sodium Sulbactam Sodium on the basis of conventional treatment.The levels of blood gas index,immune function and inflammatory factor of the two groups before and after treatment were compared.Results Before treatment,there were no significant differences in the levels of hydrogen ion concentration index (pH),partial pressure of oxygen (PaO2),and partial pressure of carbon dioxide (PaCO2) between the two groups (P＞0.05).The levels of pH and PaO2 in the two groups after treatment were higher than those before treatment,and the levels of pH and PaO2 in the observation group after treatment were higher than those in the control group,and the differences were statistically significant (P＜0.05).The level of PaCO2 in the two groups after treatment was lower than that before treatment,and the level of PaCO2 in the observation group after treatment was lower than that in the control group,and the difference was statistically significant (P ＜0.05).There were no significant differences in the levels of serum immunoglobulin A (IGA),immunoglobulin G (IgG) and immunoglobulin M (IgM) between the two groups before treatment(P＞0.05).After treatment,the levels of serum IgA,IgG,and IgM in the two groups were higher than those before treatment,and the levels of serum IgA,IgG,and IgM in the observation group after treatment were higher than those in the control group,and the differences were statistically significant (P＜0.05).Before treatment,there were no statistical differences in the levels of serum interleukin-6 (IL-6),interleukin-8 (IL-8) and tumor necrosis factor-α (TNF-α) between the two groups (P＞0.05).After treatment,the levels of serum IL-6,IL-8 and TNF-α in the two groups were lower than those before treatment,and the levels of serum IL-6,IL-8 and TNF-α in the observation group after treatment were lower than those in the control group,the differences were statistically significant (P＜0.05).Conclusion Cefoperazone Sodium Sulbactam Sodium can effectively improve blood gas index,enhance immune ability and reduce inflammatory response in elderly patients with cerebral infarction complicated with pulmonary infection.

Key words： Cerebral infarction Pulmonary infection Cefoperazone Sodium Sulbactam Sodium Immune function Inflammatory cytokines

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	CHEN Ning
	CAO Xingyi

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CHEN Ning,CAO Xingyi. Application effect of Cefoperazone Sodium Sulbactam Sodium in elderly patients with cerebral infarction complicated with pulmonary infection[J]. 中国当代医药, 2022, 29(14): 131-134.

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https://www.dangdaiyiyao.com/EN/ OR https://www.dangdaiyiyao.com/EN/Y2022/V29/I14/131

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