头孢他啶与左氧氟沙星联合治疗老年心力衰竭合并肺部感染患者的临床效果

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Abstract Objective To investigate the clinical effect of Ceftazidime combined with Levofloxacin in the treatment of elderly patients with heart failure complicated with pulmonary infection.Methods Seventy-six elderly patients with heart failure complicated with pulmonary infection who were admitted to Feicheng People′s Hospital from May 2019 to May 2020 were selected as subjects and divided into the observation group and the control group by the random number table method,with 38 patients in each group.All patients were treated with diuresis,cardiac strengthening,vasodilation and other conventional treatment.The control group was treated with Ceftazidime for injection.The observation group was treated with intravenous Levofloxacin on the basis of the control group.The levels of inflammatory factors in the two groups before and after treatment were compared,mainly including the levels of B-type natriuretic peptide(BNP),white blood cell (WBC),procalcitonin (PCT),interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α).Cardiac function indexes of the two groups were compared before and after treatment,and the changes of left ventricular diastolic diameter (LEVDD),left ventricular end systolic diameter (LVESD),left ventricular ejection fraction (LVEF)and end systolic left ventricular diameters (LVDs) were recorded.The clearance of pathogenic bacteria between the two groups was compared,and samples from the two groups were collected before and after treatment to detect the numbers of pathogenic bacteria.The therapeutic effect of the two groups were compared.Results There were no significant differences in the levels of IL-6,TNF-α,BNP,WBC and PCT between the two groups before treatment (P>0.05).The levels of IL-6,TNF-α,BNP,WBC and PCT in observation group were lower than those in control group after treatment,the differences were statistically significant (P<0.05).The levels of IL-6,TNF-α,BNP,WBC and PCT in the two groups after treatment were lower than the those before treatment,the differences were statistically significant (P<0.05).There were no significant differences in cardiac function indexes between the two groups before treatment (P>0.05).After treatment,LVESD,LEVDD and LVDs in the observation group were lower than those in the control group,and the differences were statistically significant (P<0.05).The LVEF of the observation group was higher than that of the control group after treatment,and the difference was statistically significant (P<0.05).The LVESD,LEVDD and LVDs in the two groups after treatment were lower than those before treatment,and the differences were statistically significant (P<0.05).The LVEF levels of the two groups after treatment were higher than those before treatment,and the differences were statistically significant (P<0.05).The clearance rate of pathogenic bacteria in the observation group was higher than that in the control group after treatment,and the difference was statistically significant (P<0.05).The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).Conclusion Ceftazidime combined with Levofloxacin in the treatment of senile heart failure complicated with pulmonary infection has a good therapeutic effect,which has the significance of clinical promotion.

Key words： Ceftazidime Levofloxacin Heart failure Pulmonary infection

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	LIU Yanjun
	QI Liwen

Cite this article:

LIU Yanjun,QI Liwen. Clinical effect of Ceftazidime combined with Levofloxacin in treatment of elderly patients with heart failure complicated with pulmonary infection[J]. 中国当代医药, 2022, 29(14): 135-139.

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https://www.dangdaiyiyao.com/EN/ OR https://www.dangdaiyiyao.com/EN/Y2022/V29/I14/135

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