低分子肝素治疗早发型重度子痫前期患者的疗效分析

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Abstract Objective To explore the diagnosis and treatment of low molecular-weight heparin (LMWH) early onset severe preeclampsia (EOSP) patients curative effect analysis.Methods The clinical data of 72 patients with EOSP who received treatment in Binzhou Medical School Affiliated Hospital from January 2020 to August 2021 were retrospectively analyzed.Thirty six patients receiving conventional treatment were selected as the control group,and thirty six patients receiving low-molecular-weight heparin in addition to conventional treatment were selected as the observation group.Blood pressure,24 h urine protein,amniotic fluid volume,blood coagulation and fibrinolysis function indexes,umbilical artery blood flow indexes and adverse outcomes of maternal and infant were compared between the two groups.Results Each index of two groups of patients before treatment,there was no statistically significant difference(P>0.05).After treatment,the blood pressure,24 hours urinary protein quantitative,plasma fibrinogen (FIB),D-dimer(D-D) and umbilical artery blood flow index of the observation group were lower than before treatment,and the sheep water,activated partial clotting enzyme live time (APTT),prothrombin time (PT) were higher than before treatment,the differences was statistically significant (P<0.05).After treatment,the blood pressure,24 hours urinary protein quantitative,plasma fibrinogen (FIB) and umbilical artery blood flow indicators below of the control group were lower than before treatment,the sheep water was higher than before treatment,the differences were statistically significant (P<0.05).There were no statistically significant difference in D-D,APTT and PT of control group before and after the treatment(P>0.05).After treatment,the blood pressure,24 hours urinary protein quantitative,FIB,D-D and umbilical artery blood flow index of the observation group were lower than those of the control group,and the sheep water,APTT,PT were higher than those of the control group,the differences was statistically significant (P<0.05).After treatment,the incidence of maternal complications and neonatal adverse outcomes in observation group were lower than those in the control group,the differences were statistically significant (P<0.05).Conclusion LMWH treatment of EOSP has a significant therapeutic effect,it can obviously reduce the patient′s blood pressure levels and 24 hours urinary protein quantitative,significantly increase the sheep water,effectively improve blood coagulation fibrinolytic related indicators and related parameters of umbilical artery blood flow,it can gradually restore has damaged fetus-placental blood circulation for the growth and development of the fetus in the womb,it also may be extended appropriately gestational age,reducing the occurrence of aderse outcome mother son,worthy of clinical popularization and application.

Key words： Early onset severe preeclampsia Low molecular-weight heparin Coagulation function index Umbilical artery blood flow indicator Fetus-placental blood circulation Maternal adverse pregnancy outcomes

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	LIU Jing
	ZHANG Yali
	WANG Yuwei
	LIANG Kuixiang

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LIU Jing,ZHANG Yali,WANG Yuwei, et al. Effect analysis of low molecular-weight heparin in the treatment of patients with early onset severe preeclampsia[J]. 中国当代医药, 2022, 29(14): 22-26.

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https://www.dangdaiyiyao.com/EN/ OR https://www.dangdaiyiyao.com/EN/Y2022/V29/I14/22

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