糖化白蛋白在糖尿病并发症中作用的研究进展

Abstract
Figure/Table
References (32)
Related Citation (15)

Download: PDF (468 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Diabetes mellitus is a chronic disease characterized by metabolic disorders such as insulin resistance and elevated blood sugar,and the existence of complications is its main risk factor.High blood glucose level is closely related to atherosclerosis.About 20% to 40% of diabetic patients in China are complicated with diabetic nephropathy.And some people with type 2 diabetes as early as in primary disease diagnosis before merger diabetic retinopathy,glycated albumin is a short-term glucose metabolism in patients with diabetes control a good indicator of the level of glycosylated protein as a cycle,the main composition,through a variety of ways in the development of diabetic complications plays an important role.The relationship between diabetes and inflammation and biomarkers has been described in many studies in recent years.In this paper,the role of glycosylated albumin in the development and development of common diabetic complications such as coronary heart disease,diabetic retinopathy and diabetic nephropathy was reviewed by using inflammation as a clue.

Key words： Glycosylated albumin Diabetic complication Inflammation Research progress

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	LI Huiwei
	LIU Changmei
	QIN Ming

Cite this article:

LI Huiwei,LIU Changmei,QIN Ming. Research progress on the role of glycosylated albumin in diabetic complication[J]. 中国当代医药, 2022, 29(14): 32-35.

URL:

https://www.dangdaiyiyao.com/EN/ OR https://www.dangdaiyiyao.com/EN/Y2022/V29/I14/32

[1]	中华医学会糖尿病学分会.中国2 型糖尿病防治指南（2020年版）[J].中华糖尿病杂志，2021，13（4）：315-409.
[2]	Yang P，Feng J，Peng Q，et al.Advanced Glycation End Products：Potential Mechanism and Therapeutic Target in Cardiovascular Complications under Diabetes[J].Oxid Med Cell Longev，2019：9570616.
[3]	Vigersky RA，Mcmahon C.The Relationship of Hemoglobin A1C to Time-in-Range in Patients with Diabetes[J].Diabetes Technol Ther，2019，21（2）：81-85.
[4]	Bomholt T，Adrian T，Nrgaard K，et al.The Use of HbA1c，Glycated Albumin and Continuous Glucose Monitoring to Assess Glucose Control in the Chronic Kidney Disease Population Including Dialysis[J].Nephron，2021，145（1）：14-19.
[5]	Wang Z，Xing G，Zhang L.Glycated albumin level is significantly decreased in patients suffering nephrotic syndrome[J].Prog Mol Biol Transl Sci，2019，162：307-319.
[6]	Zendjabil M.Glycated albumin[J].Clin Chim Acta，2020，502：240-244.
[7]	Vijayaraghavan B，Padmanabhan G，Ramanathan K.Determination of serum glycated albumin and high sensitivity Creactive protein in the insight of cardiovascular complications in diabetic chronic kidney disease patients[J].Afr Health Sci，2020，20（1）：308-313.
[8]	Eckart A，Struja T，Kutz A，et al.Relationship of Nutritional Status，Inflammation，and Serum Albumin Levels During Acute Illness：A Prospective Study[J].Am J Med，2020，133（6）：713-722.
[9]	Sproston NR，Ashworth JJ.Role of C-Reactive Protein at Sites of Inflammation and Infection[J].Front Immunol，2018，9：754.
[10]	Wang HJ，Lo WY，Lin LJ.Angiotensin-（1-7）decreases glycated albumin-induced endothelial interleukin-6 expression via modulation of miR-146a[J].Biochem Biophys Res Commun，2013，430（3）：1157-1163.
[11]	Roohk HV，Zaidi AR，Patel D.Glycated albumin （GA）and inflammation：role of GA as a potential marker of inflammation[J].Inflamm Res，2018，67（1）：21-30.
[19]	Soysal P，Arik F，Smtth L，et al.Inflammation，Frailty and Cardiovascular Disease[J].Adv Exp Med Biol，2020，1216：55-64.
[22]	Kolluru GK，Bir SC，Kevil CG.Endothelial dysfunction and diabetes：effects on angiogenesis，vascular remodeling，and wound healing[J].Int J Vasc Med，2012：918267.
[23]	Vidhya G，Anusha B.Diaretinopathy database-A gene database for diabetic retinopathy[J].Bioinformation，2014，10（4）：235-240
[12]	Poznyak A，Grechko AV，Poggio P，et al.The Diabetes Mellitus-Atherosclerosis Connection：The Role of Lipid and Glucose Metabolism and Chronic Inflammation[J].Int J Mol Sci，2020，21（5）：1835.
[13]	Bakkar NZ，Dwaib HS，Fares S，et al.Cardiac Autonomic Neuropathy：A Progressive Consequence of Chronic Low-Grade Inflammation in Type 2 Diabetes and Related Metabolic Disorders[J].Int J Mol Sci，2020，21（23）：9005.
[14]	Zhang ZQ，Yang YF，Yan JR，et al.Advanced glycated albumin induces macrophage pyroptosis via upregulating nucleotide-binding oligomerization domain-like receptor protein 3[J].Sheng Li Xue Bao，2019，71（6）：846-854.
[15]	Martinez Fernandez A，Regazzoni I，Brioschi M，et al.Prooxidant and pro-inflammatory effects of glycated albumin on cardiomyocytes[J].Free Radic Biol Med，2019，144：245-255.
[16]	Ieronymaki E，Daskalaki M G，Lyroni K，et al.Insulin Signaling and Insulin Resistance Facilitate Trained Immunity in Macrophages Through Metabolic and Epigenetic Changes[J].Front Immunol，2019，10：1330.
[17]	Kojta I，Chacinska M，Blachnio-zabielska A.Obesity，Bioactive Lipids，and Adipose Tissue Inflammation in Insulin Resistance[J].Nutrients，2020，12（5）：1305.
[18]	Amin MN，Hussain MS，Sarwar MS，et al.How the association between obesity and inflammation may lead to insulin resistance and cancer[J].Diabetes Metab Syndr，2019，13（2）：1213-1224.
[20]	Roohk HV，Zaidi AR，Patel D.Glycated albumin （GA）and inflammation：role of GA as a potential marker of inflammation[J].Inflamm Res，2018，67（1）：21-30.
[21]	Paradela-Dobarro B，Bravo SB，Rozados-Luis A，et al.Inflammatory effects ofin vivoglycated albumin from cardiovascular patients[J].Biomed Pharmacother，2019，113：108763.
[24]	Schalkwijk C，Lieuw-a-Fa M，van Hinsbergh V，et al.Pathophysiological role of Amadori-glycated proteins in diabetic microangiopathy[J].Semin Vasc Med，2002，2（2）：191-197.
[25]	Chen S，Cohen MP，Ziyadeh FN.Amadori-glycated albumin in diabetic nephropathy：pathophysiologic connections[J].Kidney Int Suppl，2000，77：S40-44.
[26]	Pan J，Li Q，Zhang L，et al.Serum glycated albumin predicts the progression of diabetic retinopathy-a five year retrospective longitudinal study[J].J Diabetes Complications，2014，28（6）：772-778.
[27]	Abcouwer S.Angiogenic Factors and Cytokines in Diabetic Retinopathy[J].J Clin Cell Immunol，2013，Suppl 1（11）：1-12.
[28]	Dong N，Xu B，Shi H，Lu Y，et al.miR-124 Regulates Amadori-Glycated Albumin-Induced Retinal Microglial Activation and Inflammation by Targeting Rac1[J].Invest Ophthalmol Vis Sci，2016，57（6）：2522-2532.
[29]	Vos FE，Schollum JB，Walker RJ.Glycated albumin is the preferred marker for assessing glycaemic control in advanced chronic kidney disease[J].NDT Plus，2011，4（6）：368-375.
[30]	Jun JE，Hur KY，Lee YB，et al.Glycated albumin predicts the development of early diabetic nephropathy in patients with type 2 diabetes[J].Diabetes Metab，2018，44（2）：178-180.
[31]	Lu L，Pu L，Xu X，et al.Association of serum levels of glycated albumin，C-reactive protein and tumor necrosis factor-a with the severity of coronary artery disease and renal impairment in patients with type 2 diabetes mellitus[J].Clin Biochem，2007，40（11）：810-816.
[32]	Umayahara Y，Fujita Y，Watnabe H，et al.Association of glycated albumin to HbA1c ratio with diabetic retinopathy but not diabetic nephropathy in patients with type 2 diabetes[J].Clin Biochem，2017，50（6）：270-273.