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Quick Search     Adv Search 2021 Vol. 28, No. 5 Published: 2021-02-18   4 Expression of transforming growth factor-β1 and epithelial mesenchymal transition related proteins in pancreatic cancer tissue and its clinical significance SHI Jing-long LI Bo HE Huan SONG Xiang-hui Objective To investigate the expression of transforming growth factor-β1 (TGF-β1) and epithelial mesenchymal transition (EMT) related proteins in pancreatic cancer tissue and its clinical significance.Methods A total of 60 patients with pancreatic cancer admitted to the Department of General Surgery of Guangzhou Twelfth People′s Hospital and Gastroenterology Department of the Second People′s Hospital of Guangdong Province from January 2019 to February 2020 were selected as research objects.The positive expression rates of TGF-β1 and EMT related proteins such as E-cadherin and Vimentin of pancreatic cancer tissue and paracancerous tissue of the patients were detected by immunohistochemistry method.The levels of serum carbohydrate antigen (CA) 199 and CA242 were measured.The levels of serum CA199 and CA242,lymph node metastasis and infiltration stage in patients with different expression levels of TGF-β1 and EMT related proteins in pancreatic cancer tissues were compared.And the relationship between the expression of TGF-β1 and EMT related proteins with the levels of serum CA199 and CA242,lymph node metastasis and infiltration stage in pancreatic cancer was analyzed.Results The positive expression rate of E-cadherin in pancreatic cancer tissue was lower than that in paracancerous tissue,while the positive expression rates of TGF-β1 and Vimentin in pancreatic cancer tissue were higher than those in paracancerous tissue,and the differences were statistically significant (P＜0.05).The levels of serum CA199 and CA242,the rate of lymph node metastasis and the proportion of infiltration stage as T3-T4 of patients with E-cadherin positive expression in pancreatic cancer tissue were lower than those of the patients with E-cadherin negative expression in pancreatic cancer tissue,and the differences were statistically significant (P＜0.05).The levels of serum CA199 and CA242,the rate of lymph node metastasis and the proportion of infiltration stage as T3-T4 of patients with TGF-β1 positive expression in pancreatic cancer tissue were higher than those of the patients with TGF-β1 negative expression in pancreatic cancer tissue,and the differences were statistically significant (P＜0.05).The levels of serum CA199 and CA242,the rate of lymph node metastasis and the proportion of infiltration stage as T3-T4 of patients with Vimentin positive expression in pancreatic cancer tissue were higher than those of the patients with Vimentin negative expression in pancreatic cancer tissue,and the differences were statistically significant (P＜0.05).The results of Kendall correlation analysis showed that the positive expression rate of TGF-β1 and Vimentin in pancreatic cancer tissue was positively correlated with serum CA199 and CA242 levels,lymph node metastasis rate and infiltration stage (P＜0.05),while the positive expression rate of E-cadherin in pancreatic cancer tissue was negatively correlated with serum CA199 and CA242 levels,lymph node metastasis rate and infiltration stage (P＜0.05).Conclusion In pancreatic cancer patients,the expression of TGF-β1 and Vimentin is up-regulated while the expression of E-cadherin is down regulated,which are related to tumor invasion and metastasis and may be reference indexes for tumor invasion and metastasis evaluation. 2021 Vol. 28 (5): 4-8 [Abstract] ( 52 ) HTML (41 KB)  PDF  (0 KB)  ( 8 ) 9 Effect of Tirofiban Injection in the treatment of progressive ischemic stroke YU Guo-hua ZHAO Li-wei ZHANG Fu-ding SHI Jia-wei Objective To explore the clinical effect of Tirofiban Injection in the treatment of progressive ischemic stroke (PIS).Methods A total of 82 patients with PIS admitted to Anshan Changda Hospital from February 2018 to February 2020 were selected and divided into a control group and a study group by random number table method,with 41 cases in each group.The control group received conventional treatment,and the study group received Tirofiban Injection on the basis of the control group.The treatment time was 48 hours and the treatment course was 2 weeks.The clinical efficacy,platelet function,National Institutes of Health Stroke scale (NIHSS) score,modified Rankin scale(mRS) score,inflammatory factors (interleukin-6 [IL-6],and hypersensitivity C-reactive protein [hs-CRP]) levels and bleeding events were compared between the two groups.Results The total effective rate of the study group was 95.12%,which was higher than that in the control group (80.49%),the difference was statistically significant (P＜0.05); the platelet aggregation rate,platelet adhesion rate,and CD62p of the study group were lower than those in the control group after treatment,the differences were statistically significant (P＜0.05); NIHSS score and mRS score of the study group after treatment were lower than those of the control group,the differences were statistically significant (P＜0.05);IL-6 and hs-CRP of the study group were lower than those in the control group after treatment,the differences were statistically significant (P＜0.05); the incidence of bleeding events in the study group was 9.76%,which was compared with that in the control group (4.88%),the difference was not statistically significant (P ＞0.05).Conclusion The application of Tirofiban injection is effective in PIS patients,and it is recommended to be further promoted. 2021 Vol. 28 (5): 9-12 [Abstract] ( 44 ) HTML (37 KB)  PDF  (0 KB)  ( 9 ) 13 Literature review of Langerhans cell histiocytosis with single lung involvement LIU Jia LI Yu-rong Objective To summarize the clinical data of Langerhans cell histiocytosis (LCH) patients with single lung involvement from January 2000 to April 2020,in order to improve the understanding of LCH with single lung involvement by clinicians.Methods From January 2000 to April 2020,the clinical data of LCH cases with single lung involvement in China were collected by WanFang,VIP Chinese database and China Biomedical Literature Database.Results Fourteen studies were finally included,including 17 LCH patients with single lung involvement,including 15 males(88.24%)and 2 females(11.76%).The most common clinical manifestation of LCH with single lung involvement was cough(12 cases,70.59%).The pulmonary imaging findings showed multiple cysts and nodules in both lungs,with obvious involvement in the middle and upper lung fields.The most common diagnosis method for LCH patients with single lung involvement was thoracoscopy (8 cases,47.06%).The results of pathological examination were more common in the rich cell stage and the proliferative stage.The most common immunohistochemical positive results were S-100 and CD1A(15 cases each,88.24%).The misdiagnosis rate of LCH with single lung involvement was high,with a misdiagnosis rate of 52.94%.In terms of treatment,the main treatment methods were smoking cessation and/or oral glucocorticoids.Conclusion LCH with single lung involvement is a clinically rare disease,with a male/female ratio of 7.5∶1.Coughing is the most common symptom,and imaging has certain characteristics,and the diagnosis is mainly based on pathology.LCH patients with single lung involvement with smoking risk factors should be strictly smoking cessation.Targeted therapy has been shown to be effective in LCH patients with BRAF mutations,and lung transplantation is the only effective approach for end-stage patients. 2021 Vol. 28 (5): 13-19 [Abstract] ( 43 ) HTML (54 KB)  PDF  (0 KB)  ( 9 ) 20 Development and application status of pediatric early warning scoring system JIANG Ye-jie FENG Qing-hong Pediatric early warning score (PEWS) is a kind of scoring instrument for early identification of children′s disease deterioration risk.Its scoring index can be obtained by physical examination.Because of its simplicity and convenience,PEWS is widely used in pediatric emergency department,pediatric general ward,pediatric intensive care unit and sick children transport.PEWS has many versions.Except for the Brighton pediatric early warning score and bedside pediatric early warning system score,it is still limited about the evidence of the effectiveness of other scoring systems.They need to be further verified by big data,multi center and prospective research.It is expected to formulate national or regional PEWS standards to promote the standardization of PEWS use. 2021 Vol. 28 (5): 20-23 [Abstract] ( 46 ) HTML (38 KB)  PDF  (0 KB)  ( 6 ) 24 Research progress of related signal pathways in thyroid canc SUN Jian-wei XIANG Qian Thyroid cancer is the most common malignant tumor in endocrinology system,and its development is interconnected with multiple signal pathways.The effect of mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) caused by BRAFV600E mutation and RET/PTC rearrangement could promote cellular hyperplasia and differentiation of papillary thyroid cancer.Phosphatidylinositol-3 kinase/protein kinase B (PI3K/AKT) could be activated by multiple factors and is associated with the malignant progression and invasion of follicular thyroid cancer.However,signal transduction and transcription activator 3 (STAT3) and Notch signaling pathway have different biological effects under different pathological types,clinical stages and lymph node metastasis of thyroid carcinoma.As such,this article will review research progress of related signal pathways in thyroid cancer. 2021 Vol. 28 (5): 24-28 [Abstract] ( 49 ) HTML (46 KB)  PDF  (0 KB)  ( 4 ) 29 Research progress on anticancer mechanism of Curcumin in radiotherapy for nasopharyngeal carcinoma LIU Qian；LIU Ying Radiotherapy as the first choice of nasopharyngeal carcinoma treatment has been the focus of research.Radiotherapy is ofter considered as a local therapy and the improvement of its efficacy is affected by multiple factors.Cancer cells resistance to radiotherapy induced alternation of tumor microenvironment seriously affects the effectiveness of cancer treatment.Curcumin is a kind of natural plant extract with anti-tumor effect,which can interfere with the process of tumorigenesis and development from many aspects.Curcumin has many pharmacological functions,such as promoting cell apoptosis,blocking cell cycle,anti-inflammation,anti-metastasis,immunomodulation and so on.Recently,immunotherapy is widely investigated in clinical cancer treatment due to its highly targeting property and mild side effect,especially through modulating the functional phenotype of innate and adaptive immune cell to augment radiotherapy efficacy.The immunomodulatory effect of Curcumin can ameliorate the tumor microenvironment,which greatly improves the efficacy of radiotherapy.In this review,the research progress of Curcumin on tumorigenesis and development and its association with tumor radiation resistance are summarized as follows. 2021 Vol. 28 (5): 29-32 [Abstract] ( 39 ) HTML (37 KB)  PDF  (0 KB)  ( 6 ) 33 Research status of different nursing modes for pregnant women with diabetes during pregnancy LIU Xiao-ping Gestational diabetes mellitus is prone to cause a variety of complications for pregnant women.Maternal women are prone to a variety of adverse emotions,affecting pregnancy outcomes and quality of life.The current clinical care models are diverse,and the care methods are not standardized,resulting in pregnant women unable to effectively control blood sugar,and the incidence of adverse pregnancy outcomes is increasing year by year.This study summarizes the clinical application effects of different nursing models of gestational diabetes mellitus patients in recent years and finds that there were currently high-quality nursing,individualized nursing,intensive nursing,perinatal nursing,community nursing,"trinity" seamless nursing,model nursing,and protection motivation theory nursing,clinical nursing path and systematic nursing,in which model nursing also includes information-motivation-behavior model nursing,knowledge-believing model nursing and health action process orientation theory model nursing,no matter what kind of nursing model was to improve patients′ blood sugar and reduce complications,improve disease awareness,improve nursing satisfaction,improve treatment compliance and other perspectives,clinical application results were good,can effectively protect the health of mothers and infants. 2021 Vol. 28 (5): 33-36 [Abstract] ( 41 ) HTML (39 KB)  PDF  (0 KB)  ( 9 ) 37 Progress in drug treatment of pulmonary arterial hypertension YANG Xiao-song Pulmonary arterial hypertension (PAH) is a life-threatening and fatal disease caused by a variety of known or unknown reasons that cause abnormally elevated pulmonary artery pressure,which has attracted widespread clinical attention.Clinical treatment drugs mainly include calcium channel blockers (CCB),prostacyclin,endothelin receptor antagonists (ETRA),phosphodiesterase inhibitors (PDE5i),guanylate cyclase (sGC) stimulators,etc.These drugs have been combined clinically to improve efficacy,reduce the incidence of adverse reactions.Although it can delay the course of the disease to a certain extent,improve the symptoms and prognosis,but there is no effective drug to reverse the progress of the disease.In recent years,studies have found that new targeted drugs such as vasoactive peptides(VIP),amino acid kinase inhibitors,immunosuppressive drugs,melatonin (MT),gene regulation drugs have shown a certain inhibitory effect on the progression of PAH.They are currently in the stage of research and development or clinical trials.This study introduces the pharmacological characteristics and research progress of the latest conventional drugs and new targeted drugs for the treatment of PAH. 2021 Vol. 28 (5): 37-41 [Abstract] ( 44 ) HTML (42 KB)  PDF  (0 KB)  ( 5 ) 42 Application value of rapid emergency medical score and time window in emergency treatment of patients with cerebral infarction GONG Yue-hua；RAO Gui-fen；XU Min Objective To explore the reference value of the rapid emergency medical score (REMS) and time windown for their condition judgment and effective treatment in patients with acute ischemic stroke.Methods The clinical data of 90 patients with acute cerebral infarction admitted to No.908 Hospital of the PLA Joint Logistics Support Force from January 2015 to December 2018 were analyzed retrospectively.The patients were divided into survival group (n=77) and death group (n=13) according to their living conditions.REMS was used to evaluate the survival group and the death group,including age,pulse,blood pressure,respiration,Glasgow coma scale (GCS) and percutaneous pulse oxygen saturation (SpO2).The REMS scores of 6 indexes between the two groups were compared.At the same time,the difference in time window was compared between the two groups.Results Pulse,systolic blood pressure,respiratory frequency,GCS,age and SpO2 REMS scores of patients in the death group were higher than those in the survival group,and the differences were statistically significant (P＜0.01).The average score of each item in death group was higher than that in survival group,the time window of the death group was longer than that in survival group,GCS scores of the death group were lower than those in the survival group,and the differences were statistically significant (P＜0.01).Conclusion The age,pulse,blood pressure,respiration,GSC,percutaneous pulse oxygen saturation are scored by REMS for patients with acute cerebral infarction of survival and death,which and time window have certain effects for condition judgment and effective treatment of patients with acute cerebral infarction. 2021 Vol. 28 (5): 42-45 [Abstract] ( 45 ) HTML (36 KB)  PDF  (0 KB)  ( 6 ) 46 Analysis of adherence to anti-tuberculosis treatment and its influencing factors in patients with tuberculosis complicated with acquired immune deficiency syndrome infection AO ian WUJing HU Dian-gui LIU Ping-qing Objective To explore the current status of the compliance of tuberculosis (TB) patients with acquired immune deficiency syndrome (AIDS) infection and its influencing factors,and to provide references for methods to improve the compliance of TB therapy.Methods A total of 78 patients with TB combined with AIDS were admitted to the Fifth People′s Hospital of Ganzhou City from January 2017 to December 2019 were selected as the research subjects.The self-designed questionnaire on compliance of TB and AIDS patients with anti-TB treatment was used to conduct the investigation,includs social demographical characteristics and anti-TB treatment compliance,and the influencing factors of anti-TB treatment compliance were discussed.Results Among 78 patients,42 patients (53.9%)had good compliance with anti-TB treatment.Univariate analysis indicated that there were statistically significant differences in the good compliance rate of anti-TB treatment among different marital status,economic status,cultural background,adverse drug reactions and TB awareness (P＜0.05).Multivariate analysis displayed economic status (β=-0.685,OR=0.245,95%CI=0.103-0.687),adverse drug reactions (β=0.759,OR=2.151,95%CI=1.654-3.587),awareness of TB (β=-0.524,OR=0.352,95%CI=0.214-0.864) were independent influencing factors for the compliance of TB patients with AIDS (P＜0.05).Among them,good economic status and high awareness of TB were protective factors for compliance with anti-TB treatment,and adverse drug reaction was a influencing factor for compliance with anti-TB treatment.Conclusion TB patients combined with AIDS infection generally display poor compliance with anti-TB treatment.Among them,economic status,adverse drug reactions,and awareness of TB are independent risk factors affecting compliance with anti-TB treatment. 2021 Vol. 28 (5): 46-48-52 [Abstract] ( 50 ) HTML (31 KB)  PDF  (0 KB)  ( 7 ) 49 Clinical effect of endotracheal intubation under the guidance of fiberoptic bronchoscope in the treatment of acute respiratory failure LI Qi-guan ZHEN Li-jun YUMiao Objective To observe the clinical effect of endotracheal intubation under the guidance of fiberoptic bronchoscope in the treatment of acute respiratory failure.Methods A total of 46 patients with acute respiratory failure admitted to Yangjiang Hospital of Traditional Chinese Medicine from January 2017 to December 2019 were selected as the research subjects.The patients were divided into the control group and the observation group according to the random number table method,with 23 cases in each group.The control group was treated with oral endotracheal intubation,and the observation group was treated with nasal endotracheal intubation under the guidance of fiberoptic bronchoscope.The blood gas indexes and the total incidence of complications before and after intubation were compared between the two groups.Results There were no significant differences in various blood gas indexes before intubation between the two groups (P＞0.05).The partial pressures of arterial oxygen (PaO2) at 24 and 72 hours after intubation in the observation group were higher than those in the control group,and the partial pressures of arterial carbon dioxide (Pa-CO2) at 12,24 and 72 hours after intubation in the observation group was lower than that in the control group at 12,24 and 72 hours after intubation,the differences were statistically significant (P＜0.05).The total incidence of complications in observation group was lower than that in control group,the difference was statistically significant (P＜0.05).Conclusion The treatment of acute respiratory failure by nasotracheal intubation under the guidance of fibrobronchoscope can significantly improve the blood gas index of patients with less complications,which can be popularized. 2021 Vol. 28 (5): 49-52 [Abstract] ( 48 ) HTML (33 KB)  PDF  (0 KB)  ( 7 ) 53 Application of Ringer Acetate Solution in patients with hemorrhagic shock QIAN Jin DING Zhi-wen YE Lv-qing LI Feng-hua Objective To investigate the effect of Ringer Acetate Solution of balanced resuscitation fluid on the clinical indicators of hemorrhagic shock patients,and to provide reference for the efficacy and safety of balanced resuscitation fluid in the treatment of hemorrhagic shock.Methods A total of 124 patients with traumatic hemorrhagic shock who underwent emergency surgery in Dongguan Huangjiang Hospital from April 2019 to December 2019 were selected as the research objects.The patients were divided into the observation group and the control group according to the random number table method,with 62 cases in each group.Patients in the observation group were given Ringer Acetate Solution,while those in the control group were given normal saline.Advanced pre-hospital first aid treatment,surgical treatment,salinger by injection of acetic acid liquid and physiological saline respectively for fluid resuscitation to correct shock,blood was collected before and after operation to detect D-dimer,blood calcitonin original part,thrombin time (TT) and activated clotting time (APTT),prothrombin time (PT),live enzymes among the ion concentration of electrolyte,arterial blood acid-base balance,and surgery clinical indicators of two groups were recorded.Results D-dimer,serum procalcitonin and lactic acid (LAC) in the observation group at 2 hours after surgery were lower than those in the control group,the differences were statistically significant(P＜0.05).The APTT and PT of the observation group at 2 hours after surgery were shorter than those of the control group,the differences were statistically significant (P＜0.05).The actual base excess (BE) and pH values in the observation group at 2 hours after surgery were higher than those in the control group,the differences were statistically significant (P＜0.05).There were no differences between the two groups in operation time,anesthesia time,anesthesia recovery time,intraoperative blood loss,urine volume and electrolyte level(P＞0.05).Conclusion Ringer Acetate Solution of balanced resuscitation fluid can reduce the expression of D-dimer and blood procalcitonin in patients with hemorrhagic shock,reduce blood lactic acid and improve microcirculation,which is worthy of clinical application. 2021 Vol. 28 (5): 53-57 [Abstract] ( 47 ) HTML (40 KB)  PDF  (0 KB)  ( 7 ) 58 Application of handover with standardized communication mode in preventing unplanned extubation of patients with acute and critical illness SHI Lei;YAO Li; LI Yue Objective To explore the application effect of handover with standardized communication mode in preventing unplanned extubation of patients with acute and critical diseases.Methods The clinical data of 84 cases with intubation in Department of emergency and Critical Medical in Pingxiang No.2 People′s Hospital from January 2019 to February 2020 were analyzed retrospectively.A total of 44 patients with intubation in the Department of Emergency in Pingxiang No.2 People′s Hospital from January 2019 to July 2019 were selected as the control group.A total of 40 patients with intubation in Department of Emergency and Intensive Care Unit in Pingxiang No.2 People′s Hospital from August 2019 to February 2020 were selected as the experimental group.In the control group,traditional handover was used,and in the experimental group,handover with standardized communication mode was adopted.The hospital stay,hospitalization expenses,incidence of unplanned extubation,and total incidence of complications between the two groups were compared.Results The hospital stay in the experimental group was shorter than that in the control group,and hospitalization expenses was less than that of the control group,the differences were statistically significant (P＜0.05).The unplanned extubation rate and the unplanned extubation rate of gastrointestinal tube in the experimental group were lower than those in the control group,the differences were statistically significant (P＜0.05).The total incidence of complication in the experimental group was lower than that in the control group,and the difference was statistically significant (P＜0.05).Conclusion Handover with standardized communication mode can prevent and reduce unplanned extubation in patients with an acute and critical disease,shorten the hospital stay,reduce hospitalization expenses,and reduce the occurrence of complications. 2021 Vol. 28 (5): 58-60 [Abstract] ( 42 ) HTML (31 KB)  PDF  (0 KB)  ( 7 ) 61 Clinical effect of Octreotide in the treatment of 120 patients with liver cirrhosis and upper gastrointestinal bleeding DING Bai-ling Objective To investigate the clinical effect of Octreotide in the treatment of patients with liver cirrhosis and upper gastrointestinal bleeding.Methods A total of 120 patients with liver cirrhosis and upper gastrointestinal hemorrhage admitted to the Second Affiliated Hospital of Shenyang Medical College from January 2017 to January 2020 were selected as the research subjects.These patients were divided into an observation group and a control group by random number table method,with 60 cases in each group.Patients in the control group were treated with Pituitrin,and in the observation group,they were treated with Octreotide.The clinical effect,the hemostasis rate of 1,2,3 days after treatment,hemostasis time,3 months follow-up rebleeding rate,hospital stay,blood transfusion volume and total incidence of adverse reactions were compared between the two groups.Results The total effective rate of observation group was higher than that of control group,and the difference was statistically significant (P＜0.05).The hemostatic rate of the observation group was higher than that of the control group at 1 day after treatment,and the difference was statistically significant(P＜0.05).There were no significant differences in the hemostatic rates at 2 and 3 days after treatment between the two groups (P＜0.05).The hemostatic rate of the observation group at 2 days after treatment was not significantly different from that of 1 day after treatment(P＞0.05).The hemostatic rate of the observation group at 3 days after treatment was lower than that of 1 day after treatment,and the difference was statistically significant (P＜0.05).The hemostatic rates of the control group at the 2 and 3 days after treatment were not significantly different from those of the 1 day after treatment (P＞0.05).The hemostasis time and hospitalization time in the observation group were shorter than those in the control group,and the blood transfusion amount was less than that in the control group,and the differences were statistically significant (P＜0.05).There was no significant difference in the rebleeding rate within 3 months follow-up rebleeding rate between the two groups compared with the total incidence of adverse reactions (P＞0.05).Conclusion The application of Octreotide in the treatment of liver cirrhosis complicated with upper gastrointestinal bleeding can improve the effect,promote fast hemostasis,shorten hemostasis time and hospital stay and reduce blood transfusion. 2021 Vol. 28 (5): 61-64 [Abstract] ( 47 ) HTML (33 KB)  PDF  (0 KB)  ( 7 ) 65 Analysis of pathogenic characteristics of pulmonary infection in elderly patients with acute cerebral infarction SHENG Lin-lin Objective To investigate the distribution of pathogenic microorganisms and drug resistance of pulmonary infection in elderly patients with acute cerebral infarction.Methods A total of 900 elderly patients with acute cerebral infarction and pulmonary infection who were admitted to Iron and Coal General Hospital of Liaoning Health Industry Group from October 2014 to October 2019 were selected as the research subjects.Sputum specimens and respiratory secretions of the patients were collected and performed with strain identification and drug susceptibility tests to analyze the distribution of pathogenic bacteria and drug resistance.Results A total of 860 strains of pathogenic microorganisms were isolated from the sputum specimens of 900 patients with pulmonary infections,mainly including 12.55% of Grampositive bacteria,75.23% of Gram-negative bacteria,and 12.21% of fungi.Acinetobacter baumannii,pseudomonas aeruginosa,and stenotrophomonas maltophilia were three major Gram-negative bacteria and were highly resistant to drugs such as Aztreonam and Ampicillin,and had the lowest resistance to Cefoperazone/Sulbactam.Among 108 strains of the Gram-positive bacteria,64.81% of Methicillin-resistant staphylococci were found.In the fungal test,the fungi were poorly resistant to Flucytosine,Itraconazole,Amphotericin B and Fluconazole.Conclusion Pulmonary infections in elderly patients with acute cerebral infarction are mostly multi-strain mixed infections,of which Gram-negative bacteria are the most common,and clinical treatment is difficult.It is necessary to apply the most reasonable antibacterial drugs to patients based on the results of drug sensitivity tests. 2021 Vol. 28 (5): 65-67 [Abstract] ( 39 ) HTML (27 KB)  PDF  (0 KB)  ( 8 ) 68 Effect of 890 nm infrared laser in the treatment of diabetic peripheral neuropathy ZHOU Fan LAO Dan-hua LI Ting-wei NONG Gui-min HUANG Chao-shuo LIAO Hong ZHANG Quan Objective To explore the clinical application value of 890 nm infrared laser in the treatment of diabetic peripheral neuropathy.Methods A total of 80 cases with type 2 diabetes mellitus complicated with diabetic peripheral neuropathy from January 2018 to March 2020 in the Department of Endocrine in the First People′s Hospital of Qinzhou City were randomly divided into two groups,40 case in each group.The control group was received Epalrestat orally before meals,the observation group received 890 nm infrared laser irradiation on the basis of control group.The neurological deficit score (NDS),nerve conduction function of lower limbs and biochemical indexes related to cognitive function (S-100B protein，neuron-specific enolase [NSE]) were compared between the two groups before and after treatment.Results There was no significant difference in NDS scores between the two groups before treatment (P＞0.05).The NDS score of the observation group after treatment was lower than that before treatment and lower than that of the control group,with statistical significance (P＜0.05).After treatment,the motor and sensory conduction velocity of peroneal nerve in lower limb nerve conduction function of the two groups were higher than those before treatment,and higher than those in the control group,with statistical significance (P＜0.05).After one cycle of treatment,the levels of S-100B protein and NSE in the observation group were lower than those before treatment,and lower than those in the control group,and the differences were statistically significant (P＜0.05).Conclusion For diabetic peripheral neuropathy patients,890 nm infrared laser irradiation therapy can effectively improve peripheral nerve function,so it also can improve nerve conduction ability. 2021 Vol. 28 (5): 68-70-81 [Abstract] ( 43 ) HTML (32 KB)  PDF  (0 KB)  ( 6 ) 71 Study on the cut-off point of the first standard time of glycosylated hemoglobin JIANG Sheng-qiang WANG Jing-jing DONG Zhi-chun WANG Ya-ming Objective To explore the intensive treatment time for control of glycosylated hemoglobin in diabetic patients with intensive blood glucose control for the first time.Methods Patients were collected who were hospitalized for the first time in the Department of Endocrinology of Shengzhou People′s Hospital (hereinafter referred to as "our hospital") for intensive blood glucose control from September 2017 to December 2019,and returned to our hospital within 120 days from the date of intensive blood glucose control.According to the diabetes diagnosis and treatment guidelines,glycosylated hemoglobin＜7% was considered as blood glucose control meeting the standard.Results A total of 119 patients revisited within 120 days from the date of intensive blood glucose control,including 80 males and 39 females.The age ranged from 19 to 85 years old,with an average age of (50.7±14.3) years old.The interval time of first followup visit was (70.8±25.7) days.The first time to reach the blood glucose standard occurred on the forty-fifth day after the initiation of intensive control of blood glucose.The cut-off point for the control of glycosylated hemoglobin within the normal range occurred on the fifty-ninth day of the first intensive blood glucose control.Conclusion The cut-off point of the earliest revisit for glycosylated hemoglobin control meeting the standard is the forty-fifth day from the initiation of intensive blood glucose control.The earliest cut-off point for revisit when the glycosylated hemoglobin is fully controlled within the normal range is the sixtieth day from the initiation of intensive control of blood glucose.There is no clinical significance when rechecking glycosylated hemoglobin within 45 days from the initiation of intensive blood glucose control. 2021 Vol. 28 (5): 71-74 [Abstract] ( 52 ) HTML (34 KB)  PDF  (0 KB)  ( 8 ) 75 Effect of laparoscopic transabdominal preperitoneal prosthesis on stress hormone and degree of pain in adult inguinal hernia YANG Yong Objective To explore the effect of laparoscopic transabdominal preperitoneal prosthesis (TAPP) on stress hormone and degree of pain in adult inguinal hernia.Methods A total of 80 adult patients with inguinal hernia who were admitted to the Sixth People′s Hospital of Jiujiang from December 2017 to April 2020 were selected as the research objects and divided into the control group (40 cases) and the observation group (40 cases) according to random number table method.The control group was treated with open tension-free herniorrhaphy,and the observation group underwent TAPP.The total clinical effective rate,stress hormone level,and degree of pain were compared between the two groups.Results The total clinical effective rate of the observation group was higher than that of the control group,and the difference was statistically significant (P＜0.05).There were no significant differences in stress hormone levels between the two groups before operation (P＞0.05).The cortisol (Cor),aldosterone (ALD) and norepinephrine (NE) levels at 3 d after operation in the observation group were lower than those in the control group,the differences were statistically significant (P＜0.05).The Cor,ALD and NE levels at 3 d after operation in both groups were higher than those before operation,and the differences were statistically significant (P＜0.05).There was no significant difference in preoperative visual analogue scale (VAS) score between the two groups (P＞0.05).The VAS score at 3 d after operation in the observation group was lower than that of control group,and the difference was statistically significant (P＜0.05).The VAS scores at 3 d after operation in both groups were lower than those before operation,and the differences were statistically significant (P＜0.05).Conclusion Adult inguinal hernia patients with TAPP treatment,its effect is accurate,the clinical efficiency is high,the stress response of the patients is small,the degree of postoperative pain is low,it is worth popularizing. 2021 Vol. 28 (5): 75-77-92 [Abstract] ( 58 ) HTML (32 KB)  PDF  (0 KB)  ( 8 ) 78 Effect of automatic ligation of hemorrhoids combined with external hemorrhoid excision and suture on wound healing time and complications in patients with annular prolapse mixed hemorrhoids RUAN Yong-jun；LANG Jin-yuan；LIU Ru-feng Objective To investigate the effect of automatic ligation of hemorrhoids (RPH) combined with external hemorrhoid excision and suture on wound healing time and complications in patients with annular prolapse mixed hemorrhoids.Methods A total of 64 patients with annular prolapse mixed hemorrhoids admitted to the Department of Anorectal in Lianjiang People′s Hospital from April 2018 to April 2020 were selected as the research subjects for retrospective analysis,and the patients were divided into the reference group (n=32) and the research group (n=32) according to different treatment methods.The control group was treated with traditional internal ligation and external stripping,while the research group was treated with RPH combined with external hemorrhoid excision and suture.The total effective rate,wound healing time,hospitalization time,first defecation pain score,anal function and the total incidence of complications were observed and compared between the two groups.Results The total effective rate of the study group was higher than that of the reference group,and the difference was statistically significant (P＜0.05).The total incidence of complications in the study group was lower than that in the reference group,and the difference was statistically significant (P＜0.05).The wound healing time and hospitalization time of the study group were shorter than those of the control group,and the score of first defecation pain was lower than that of the control group,the differences were statistically significant (P＜0.05).After treatment,the resting pressure and diastolic pressure of anal canal in the study group were higher than those in the reference group,and the differences were statistically significant (P＜0.05).Conclusion RPH combined with external hemorrhoids resection and suture is effective in the treatment of annular prolapse mixed hemorrhoids.It can not only shorten the wound healing time and hospitalization time,but also relieve the pain of the first defecation,promote the recovery of anal function,and reduce the incidence of complications. 2021 Vol. 28 (5): 78-81 [Abstract] ( 40 ) HTML (34 KB)  PDF  (0 KB)  ( 5 ) 82 Influence of different approaches of laparoscopic radical resection of rectal cancer on the treatment effect of patients with rectal cancer HUANG Ke-hua Objective To analyze the application effect of different approaches of laparoscopic radical resection of rectal cancer on therapeutic effect of patients with rectal cancer.Methods A retrospective analysis of the clinical data of 120 patients with rectal cancer who were treated in Liaoyang Central Hospital from April 2017 to October 2019 was conducted.All patients underwent laparoscopic radical resection of rectal cancer.According to the different surgical approaches,they were divided into control group (traditional medial approach,n=60) and observation group (cephalic medial approach,n=60).The surgical related indicators and postoperative complications were compared in the two groups.Results There was no significant difference in intraoperative blood loss between the two groups (P＞0.05).The operation time and lymph node sweep time around the naked inferior mesenteric artery (IMA) of the observation group were shorter than those of the control group,the number of swept lymph nodes in 253 groups in the observation group was more than that of the control group,and the differences were statistically significant (P ＜0.05).There was no statistically significant difference in the total incidence of complications between the two groups (P＞0.05).Conclusion Laparoscopic radical resection of rectal cancer using cephalic middle approach is more effective,and it is more conducive to shorten the time of lymph node sweeping around IMA,and efficiently remove lymph nodes in 253 groups,with fewer postoperative complications and higher safety. 2021 Vol. 28 (5): 82-84 [Abstract] ( 44 ) HTML (30 KB)  PDF  (0 KB)  ( 7 ) 85 Clinical effect of subcutaneous access to laparoscopic inguinal lymph node dissection in the treatment of patient with vulvar cancer ZHU Ya-fei；XIE Xiao-ying；YE Ping；XU Ling Objective To explore the clinical effect of subcutaneous access to laparoscopic inguinal lymph node dissection in the treatment of patient with vulvar cancer.Methods A total of 36 patients with vulvar cancer admitted to the First Affiliated Hospital of Gannan Medical College from October 2017 to May 2020 were selected and divided into the study group and the control group according to the random number table method,with 18 patients in each group.The control group was treated with open lymph node dissection,while the study group was treated with subcutaneous access to laparoscopic inguinal lymph node dissection.The short-term efficacy,hospitalization,surgical results and complications of the patients were observed and compared.Results The short-term efficacy of the study group was higher than that of the control group,and the difference was statistically significant (P＜0.05).The total treatment time and postoperative hospital stay in the study group were shorter than those in the control group,and the differences were statistically significant (P＜0.05).The intraoperative blood loss of the study group was less than that of the control group,and the difference was statistically significant (P＜0.05).The postoperative drainage tube placement time of the study group was shorter than that of the control group,and the difference was statistically significant (P＜0.05).There were no significant difference in operation time and the number of left and right lymph nodes between the two groups (P＞0.05).The number of complications in the study group was less than that in the control group,with statistically significant difference (P＜0.05).Conclusion The application of subcutaneous access to laparoscopic inguinal lymph node dissection in the treatment of vulvar cancer can significantly improve the short-term clinical effect,and at the same time,greatly shorten the duration of treatment and hospitalization,and promote the clinical rehabilitation of patients.In addition,it can effectively improve the outcome of surgical treatment.Because of its small incision,the incidence of clinical complications has been continuously reduced,and it has high safety,which is worthy of promotion. 2021 Vol. 28 (5): 85-88 [Abstract] ( 47 ) HTML (38 KB)  PDF  (0 KB)  ( 6 ) 89 Clinical effect of selective cervical lymph node dissection in the treatment of papillary thyroid carcinoma XUE Feng JIANG Xue▲ Objective To explore the clinical effect of selective cervical lymph node dissection in the treatment of papillary thyroid cancer.Methods A total of 120 patients with papillary thyroid cancer admitted to Dalian Central Hospital from March 12,2018 to March 18,2019 were selected as the research subjects.They were divided into the observation group (n=60) and the control group (n=60) according to odd and even numbers randomization.In the control group,conventional thyroidectomy was used,and in the observation group,selective cervical lymph node dissection was adopted.The number of lymph node dissections,hospital stay,intraoperative blood loss,operation time,visual analog scale(VAS) score,positive rate at 7 days after surgery,incidence of complications,12 months of recurrence rate,nodule volume reduction rate,nodule volume and the level of thyroid stimulating hormone (TSH),serum free triiodothyronine(FT3),and serum free thyroxine (FT4) were compared between the two groups.Results The incidence of complications,positive rate of 7 days after operation,12-month recurrence rate,VAS score of the observation group were lower than those of the control group,with statistical significance (P＜0.05).The nodule volume of the observation group was less than that of the control group,the intraoperative blood loss of the observation group was less than that of the control group,and the differences were statistically significant (P＜0.05).The number of lymph node dissections of the observation group was more than that of the control group,and the difference was statistically significant (P＜0.05).The operation time and hospital stay of the observation group were shorter than those of the control group,and the differences were statistically significant (P＜0.05).The levels of FT3,FT4,TSH and the reduction rate of nodule volume of the observation group were higher than those of the control group,with statistical significance (P＜0.05).Conclusion Selective cervical lymphadenectomy for patients with papillary thyroid cancer has a remarkable effect,which can improve thyroid function,and reduce postoperative incidence of complications and the current nodule volume. 2021 Vol. 28 (5): 89-92 [Abstract] ( 48 ) HTML (35 KB)  PDF  (0 KB)  ( 6 ) 93 Effect comparison of Oxaliplatin combined with Capecitabine and Oxaliplatin combined with Tegafur Gimeracil Oteracil Potassium in the treatment of advanced colorectal cancer WU Yu-ling Objective To compare the effect of Oxaliplatin combined with Capecitabine and Oxaliplatin combined with Tegafur Gimeracil Oteracil Potassium in the treatment of advanced colorectal cancer.Methods A total of 66 patients with advanced colorectal cancer admitted to the Third People′s Hospital of Jingdezhen City from August 2016 to August 2017 were selected as the research subjects.According to the random number table method,they were divided into the Capecitabine group (n=33) and the Tegafur Gimeracil Oteracil Potassium group (n=33).In the Capecitabine group,Oxaliplatin combined with Capecitabine was used,and in the Tegafur Gimeracil Oteracil Potassium group,Oxaliplatin combined with Tegafur Gimeracil Oteracil Potassium was used for treatment.The clinical efficacy,adverse reactions and median time to disease progression (TTP) were compared between the two groups after 2 courses of treatment.Results There was no statistically significant difference in the total effectiveness rate between the two groups (P＞0.05).The incidence of nausea and vomiting and hand-foot syndrome in the Tegafur Gimeracil Oteracil Potassium group were higher than those in the Capecitabine group,and the differences were statistically significant (P＜0.05).There was no significant difference in the median TTP between the two groups (P＞0.05).Conclusion In patients with colorectal cancer,Oxaliplatin combined with Capecitabine or Tegafur Gimeracil Oteracil Potassium can obtain similar effects,but Oxaliplatin combined with Tegafur Gimeracil Oteracil Potassium can reduce the occurrence of nausea and vomiting and hand-foot syndrome. 2021 Vol. 28 (5): 93-95 [Abstract] ( 44 ) HTML (28 KB)  PDF  (0 KB)  ( 7 ) 96 Expression and significance of receptor for advanced glycation end products and vascular endothelial growth factor protein in non-small cell lung cancer MAO Zhi-fang Objective To investigate the expression and significance of receptor for advanced glycation end products(RAGE) and vascular endothelial growth factor (VEGF) protein in non-small cell lung cancer.Methods Ten patients with non-small cell lung cancer admitted to Jiangxi Provincial People′s Hospital from January 2018 to December 2019 were selected.A total of 10 samples of non-small cell lung cancer tissues were collected,and another 10 samples of adjacent normal tissues were collected as controls.Realtime PCR was used to detect the expression of RAGE and VEGF in non-small cell lung cancer tissues and adjacent normal tissues,and Pearson was used to analyze the correlation between RAGE and VEGF in non-small cell lung cancer tissues.Results The expression level of RAGE mRNA in non-small cell lung cancer tissues (0.015±0.009) was lower than that in adjacent normal tissues (1.000±0.000),and the difference was statistically significant (P＜0.01).The expression level of VEGF mRNA in non-small cell lung cancer tissues (4.040±1.650) was higher than that in adjacent normal tissues (1.000±0.000),and the difference was statistically significant (P＜0.01).Pearson correlation analysis showed that RAGE was negatively correlated with VEGF expression in non-small cell lung cancer tissues (r=-0.654,P＜0.01).Conclusion The low expression of RAGE and the high expression of VEGF in lung cancer could be used as an effective index to judge the occurrence of lung cancer. 2021 Vol. 28 (5): 96-99 [Abstract] ( 50 ) HTML (34 KB)  PDF  (0 KB)  ( 7 ) 100 Application value of Nano-Carbon combined with Methylene Blue tracer method in sentinel lymph node biopsy of breast cancer YUAN Quan；WANG Wei Objective To observe the application value of Nano-Carbon combined with Methylene Blue tracing method in sentinel lymph node biopsy of breast cancer,in order to provide clinical reference.Methods A total of 234 breast cancer patients diagnosed by breast tumor biopsy or puncture pathology in the First People′s Hospital of Jining City from May 2018 to September 2019 were selected and randomly divided into the combined group,the Methylene Blue group and the Nano-Carbon group,with 78 cases in each group.Three groups of patients were treated with breast cancer sentinel lymph node biopsy using Nano-Carbon combined with Methylene Blue tracing method,pure Methylene Blue tracing method and pure Nano-Carbon tracing method.The detection of sentinel lymph nodes in the three groups were observed and recorded.Results There were no significant difference in the detection rate,sensitivity,false negative rate and accuracy of the three groups (P＞0.05).The average number of sentinel lymph nodes detected and the average number of positive sentinel lymph nodes in the combined group detected were higher than those in the methylene blue group and the nano-carbon group,the differences were statistically significant (P＜0.01).Conclusion The application of Nano-Carbon combined with Methylene Blue tracing method for breast cancer sentinel lymph node biopsy has obvious advantages in the number of detections,and which is worthy of clinical promotion and application. 2021 Vol. 28 (5): 100-102-107 [Abstract] ( 46 ) HTML (32 KB)  PDF  (0 KB)  ( 6 ) 103 Application of hysteroscopy in the study of the relationship between endometrial thickness and related diseases in postmenopausal women HUANG Shu-hua Objective To observe the diagnostic value of hysteroscopy on the relationship between endometrial thickness and endometrial diseases in postmenopausal women.Methods A total of 1048 postmenopausal women with local registration in Liantang Town of Nanchang County from October to December 2019 were selected for vaginal ultrasound to check the endometrial thickness and divided into two groups according to vaginal ultrasound results.Postmenopausal women with endometrium ＜5 mm and endometrium ≥5 mm were further subjected to hysteroscopy and analyzed with the endometrial pathology results,and the differences between the general condition of women and the incidence of endometrial diseases in postmenopausal women with endometrium ＜5 mm and endometrium ≥5 mm were analyzed to explore the relationship between endometrial thickness and endometrial lesions.Results The age,number of pregnancy,menopausal time,body mass index,and intimal thickness were compared between two groups,the differences were statistically significant (P＜0.05).The incidence rates of simple or complex intimal hyperplasia,atypical intimal hyperplasia,chronic non-specific Heterosexual endometritis,endometrial polyps,submucosal fibroids,endometrial epithelioma formation or endometrial cancer were compared between two groups,the differences were statistically significant (P＜0.05).Diagnostic rates of simple or complex endometrial hyperplasia,atypical endometrial hyperplasia,chronic nonspecific endometritis,endometrial polyps,submucosal fibroids,endometrial epithelioma formation or endometrial cancer in hysteroscope were compared with pathological diagnosis,their coincidence rates were 100.00%,85.71%,96.15%,96.56%,80.00%,75.00%,respectively.Conclusion The incidence of benign and malignant endometrial diseases in women with endometrium ≥5 mm is increased.The coincidence rate of hysteroscopy diagnosis and pathlogical diagnosis is more than 75%,which can be used as a screening method for endometrial diseases in postmenopausal women. 2021 Vol. 28 (5): 103-107 [Abstract] ( 44 ) HTML (37 KB)  PDF  (0 KB)  ( 7 ) 108 Effect of Compound Nutritional Vitamins on children′s nutritional status,growth and development HE Shi-jie Objective To explore the effect of compound nutritional vitamins on children′s nutritional status,growth and development.Methods A prospective study was conducted on 115 children who underwent physical examination in Maternal and Child Health Hospital of Jiangxi Province from March 2018 to July 2019,and they were divided into control group (n=58) and observation group (n=57) according to random number table method.The children in the control group were given single Vitamin A supplement,and the children in the observation group were given Compound Nutritional Vitamins supplement.The nutritional status,growth and development of children and the incidence of malnutrition were compared between the two groups.Results Before treatment,there were no significant differences in the contents of hemoglobin (Hb),vitamin A,height,weight,calcium,iron and zinc between the two groups (P＞0.05).After treatment,the contents of Hb,vitamin A,height,weight,calcium,iron and zinc in the observation group were all higher than those before treatment,and the contents of Hb,vitamin A,height,weight,calcium,iron and zinc in the observation group were higher than those in the control group,with statistically significant differences (P＜0.05).The total incidence of malnutrition in the observation group (7.02%) was lower than that in the control group (20.69%),and the difference was statistically significant (P＜0.05).Conclusion The application of Compound Nutritional Vitamins for children is good,which can effectively improve the nutritional status of children,promote growth and development,and reduce the incidence of malnutrition.It′s worthy promoting. 2021 Vol. 28 (5): 108-110-114 [Abstract] ( 53 ) HTML (31 KB)  PDF  (0 KB)  ( 4 ) 111 Application value of serum 25-hydroxyvitamin D3 level in the assessment of children with bronchial pneumonia ZHOU Li-hua；WANG Fu-ying；ZHONG Jin-tao Objective To investigate the application of serum 25-hydroxyvitamin D3 level in the assessment of children with bronchial pneumonia.Methods Retrospective analysis was used to collect the clinical data of 141 children with bronchial pneumonia who were treated in Shangrao Maternal and Child Health Hospital from January 2018 to February 2020.According to their severity,they were divided into the mild group (n=47),the moderate group (n=47) and the severe group (n=47).In addition,a total of 47 children who underwent physical examinations in Shangrao Maternal and Child Health Hospital during the same period were selected as the control group.The serum 25-hydroxyvitamin D3 levels of the four groups were tested and compared,and the application value of serum 25-hydroxyvitamin D3 levels in the assessment of children with bronchial pneumonia was analyzed.Results Among these four groups,the level of serum 25-hydroxyvitamin D3 in the severe group was lower than that of the moderate group,mild group and control group,and the difference was statistically significant (P＜0.05).The linear regression test showed that the serum 25-hydroxyvitamin D3 level (X1) was closely related to the condition of bronchopneumonia in children (P＜0.05).The linear regression equation was Y=1.173+0.019X1.The score of the children′s bronchopneumonia disease assessment scale in the severe group was higher than that in the mild and moderate groups with statistical significance (t=14.315,6.470,P=0.000).Children in the moderate group had a higher score on the pediatric bronchopneumonia disease assessment scale than the mild group,and the difference was statistically significant (t=10.556,P=0.000).Conclusion The level of serum 25-hydroxyvitamin D3 has a certain correlation with the condition of bronchial pneumonia in children,and it can be used as one of the important indicators to evaluate bronchial pneumonia in children and provide important reference value for clinical diagnosis and treatment. 2021 Vol. 28 (5): 111-114 [Abstract] ( 53 ) HTML (35 KB)  PDF  (0 KB)  ( 8 ) 115 Effect of rapid rehabilitation model on recovery after cesarean section in pregnant women with pregnancy-induced hypertension WANGYan Objective To explore the effect of rapid rehabilitation on postpartum recovery of parturient with cesarean section.Methods From January 2019 to March 2020,122 pregnant women with PIH who were admitted to Wuzhou Red Cross Society Hospital in Guangxi Zhuang Autonomous Region for elective cesarean section were selected as the subjects.They were divided into study group and routine group by random number table method,61 cases in each group.The routine group used the traditional rehabilitation mode in the perioperative period of cesarean section,and the study group used the rapid rehabilitation surgical mode in the perioperative period of cesarean section.The postoperative pain degree，urination time,recovery exhaust time and hospitalization time were compared between the two groups,and the complications such as postoperative shivering,nausea and vomiting,urinary retention,postoperative infection and intestinal obstruction were statistically analyzed.Results The visual analog scales (VAS) score in the study group was lower than that in the routine group,and the urination time,recovery time and hospitalization time were shorter than those in the routine group,the differences were statistically significant (P＜0.05).The total incidence of complications in the study group was 6.56%,which was lower than 24.59% in the routine group,the difference was statistically significant (P＜0.05).Conclusion For pregnant women with cesarean section,the application of rapid rehabilitation surgery in perioperative period can reduce incision pain,reduce related complications,and promote postoperative recovery of parturient,which is worthy of clinical application. 2021 Vol. 28 (5): 115-117 [Abstract] ( 45 ) HTML (30 KB)  PDF  (0 KB)  ( 9 ) 118 Application value of ear wash ball combined with inverted position in the cleaning of respiratory secretions of normal delivery newborns LUO Ai-xiang XIAO Wen-ping XIE Qin-ying Objective To explore the application value of the ear wash ball combined with inverted position in the cleaning of respiratory secretions of normal delivery newborns.Methods From March 2019 to April 2020,240 cases of normal delivery newborns in Ganzhou Maternal and Child Health Hospital,Jiangxi Province were selected as the research objects.They were divided into the control group and the experimental group by random number table method,120 cases in each group.In the control group,the respiratory secretions were cleaned by routine method,in the experimental group used ear wash ball combined with inverted positions to clear respiratory secretions.The asphyxiation rate,abnormal heartbeat rate,vomiting rate,and milk rejection rate between the two groups were compared.Results The total neonatal asphyxia rate in the experimental group was 1.67%,which was lower than that in the control group(11.67%),which was statistically significant (P＜0.05).The total incidence of abnormal heartbeat in the experimental group was 2.50%,which was lower than that in the control group (10.00%),which was statistically significant (P＜0.05).The vomiting rate in the experimental group was 4.17%,which was lower than that in the control group of 23.33%,and the difference was statistically significant (P＜0.05).The milk rejection rate of the experimental group was 2.50%,which was lower than that in the control group (15.00%),the difference was statistically significant (P＜0.05).Conclusion The application of ear wash ball combined with inverted position in the cleaning of respiratory secretions of newborns in normal delivery can reduce the rate of neonatal asphyxia,abnormal heartbeat,vomiting and milk rejection. 2021 Vol. 28 (5): 118-120 [Abstract] ( 49 ) HTML (30 KB)  PDF  (0 KB)  ( 6 ) 121 Effect of family-group-based pregnancy health care service model led by midwives applied to pregnant women XIE Liu-ru ZHU Feng-juan DING Li-juan LI Qiu-mei ZENG Xiao-heng Objective To explore the clinical effect of the family group-based pregnancy care service model dominated by midwives applied to pregnant women.Methods Retrospective analysis of the data on the 120 primiparas who were admitted to Dongguan Songshan Lake Central Hospital from January 2019 to December 2019 was made and divided into the observation group (60 cases) and the control group (60 cases) according to the pregnancy health care model.The control group participated in regular pregnancy checkups,school education for pregnant women,and WeChat groups for pregnant women schools.The observation group received family group-based pregnancy health care services led by midwives.The weight control,neonatal weight and cesarean section rate were compared between the two groups.Results The weight at 28 weeks of pregnancy,weight before delivery and the weekly gain during the third trimester of the observation group were lower than those of the control group,and the differences were statistically significant (P＜0.05).The weight of the newborn in the observation group was lower than that in the control group,the difference was statistically significant (P＜0.05).The rate of cesarean section in the observation group was lower than that in the control group,and the difference was statistically significant (P＜0.05).Conclusion The family group-based pregnancy health care service model dominated by midwives has a significant effect when applied to pregnant women.It can effectively manage the weight of pregnant women and newborns and improve the outcome of maternal and child.It is worthy of attention and promotion. 2021 Vol. 28 (5): 121-123 [Abstract] ( 48 ) HTML (31 KB)  PDF  (0 KB)  ( 8 ) 124 Application of anti-Müllerian hormone and insulin resistance in polycystic ovary syndrome DU Wei-na ZHANG Xiao-lian MAYao Objectives To explore the characteristics and application values of serum anti-Müllerian hormone (AMH)and insulin resistance (IR) in patients with polycystic ovary syndrome (PCOS).Methods A retrospective analysis of 479 infertile patients who were treated in Dalian Maternal and Child Health Hospital from December 2018 to October 2019 was performed.In the research,patients diagnosed as PCOS were considered as PCOS group (315 cases),and other infertile patients were regarded as the control group (164 cases).Moreover,on the basis of the existence of IR,patients with PCOS were divided into PCOS-IR group (111 cases) and PCOS-NIR group (204 cases).The differences and significance of the ages,AMH,total testosterone (T),luteinizing hormone (LH),follicle stimulating hormone (FSH),estradiol(E2),triglyceride (TG),high density lipoprotein (HDL) and low density lipoprotein (LDL) were compared among three groups.Results The values of AMH,T,LH,E2,BMI,HOMA-IR,TG,LDL of PCOS group were higher than those of the control group,which were statistically significant (P＜0.05).FSH and HDL between the two groups were not statistically significant (P＞0.05).BMI,AMH,TG of PCOS-IR group were higher than those of PCOS-NIR group and the control group,which were statistically significant (P＜0.05).HDL of PCOS-IR group was lower than that of PCOS-NIR group and the control group,which was statistically significant (P＜0.05).LDL of PCOS-IR group was higher than that of the control group,which was statistically significant (P＜0.05).AMH,TG and LDL of PCOS-NIR group were higher than those of the control group,which were statistically significant (P＜0.05),and the differences of BMI and HDL between the two groups were not statistically significant (P＞0.05).Conclusions The level of AMH of patients with PCOS is significantly higher than that of patients of non-PCOS,which has a guiding significance for clinical diagnosis.insulin resistance can aggravate the abnormal lipid metabolism of PCOS,which should be paid great attention to and actively intervened in the therapy of patients with PCOS. 2021 Vol. 28 (5): 124-126-130 [Abstract] ( 42 ) HTML (31 KB)  PDF  (0 KB)  ( 7 ) 127 Analysis of risk factors for severe infection in children with acute lymphoblastic leukemia during myelosuppression stage after chemotherapy LIN Chun-yan CHEN Qiong WU Ting-bo LI Li-yu HUANG Chun-hui Objective To explore the risk factors of severe infection in the bone marrow suppression phase after chemotherapy of childhood acute lymphoblastic leukemia (ALL).Methods In this study,90 newly diagnosed children with ALL admitted to Zhongshan Hospital Affiliated to Sun Yat-sen University from January 2017 to January 2020 were selected as the research objects,and were divided into the infection group (n=63) according to whether infection occurred during the bone marrow suppression phase after chemotherapy and the non-infected group (n=27),was divided into a severely infected group (n=24) and a non-severely infected group (n=39) according to whether severe infection occurred during the bone marrow suppression phase after chemotherapy.Logistics was used to analyze the risk factors of severe infection in the myelosuppressive phase of children with ALL after chemotherapy.Results After chemotherapy in children with ALL,the time of neutrophil deficiency in the infection group during the myelosuppression stage was longer than that in the non-infected group,the incidence of skin and mucosal damage was higher than that in the noninfected group,in the infection group,the neutrophil count and hemoglobin levels were lower than those of the non-infected group,the differences were statistically significant (t=21.772,P=0.000; χ2=4.120,P=0.042; t=15.669,P=0.000;t=2.070,P=0.041).The univariate analysis showed that the neutrophil deficiency in the severe infection group was longer than that in the non-severe infection group,the incidence of skin and mucosal damage was higher than that in the non-severe infection group,and the neutrophil count and hemoglobin levels were lower than those in the non-severe infection group,the differences were statistically significant (t=3.251,P=0.000; χ2=10.470,P=0.001; t=22.907,P=0.000; t=3.893,P=0.000).Multivariate Logistic regression analysis showed that the main risk factors for severe infection in the myelosuppressive phase of childhood ALL after chemotherapy were low neutrophil count,long neutrophil deficiency,high incidence of skin and mucosal damage,and low hemoglobin level (P＜0.05).Conclusion Low neutrophil count,long neutrophil deficiency,high incidence of skin and mucosal damage,and low hemoglobin levels are risk factors for severe infection in the myelosuppressive phase of childhood ALL after chemotherapy,and the risk of severe infection in children should be addressed factors are targeted for prevention and control to reduce the incidence of severe infections in the myelosuppressive phase of childhood ALL after chemotherapy and improve the prognosis of children. 2021 Vol. 28 (5): 127-130 [Abstract] ( 52 ) HTML (30 KB)  PDF  (0 KB)  ( 7 ) 131 Effect of electrical stimulation rehabilitation therapy on pelvic floor muscle electromyography parameters under cesarean section LI Peng-rong Objective To investigate the effect of electrical stimulation rehabilitation therapy on pelvic floor muscle electromyogram(EMG)parameters under cesarean section.Methods Retrospective analysis of the clinical data of 153 parturients who delivered in Yichang Maternal and Child Health Hospital hospital from January 2017 to January 2019 was made.According to different treatment methods,they were divided into the observation group (n=77) and the control group (n=76).In the observation group,electrical stimulation rehabilitation therapy was used,and in the control group,conventional rehabilitation exercise therapy was adopted.The differences in pelvic floor muscle strength classification and EMG parameters including speed value,peak value,vitality value,relaxation value,and work value between the two groups after cesarean section were recorded.Results The muscle strength of type I muscle fibers of the observation group was better than that of the control group,and the difference was statistically significant (P＜0.05).There was no statistically significant difference in the muscle strength of type Ⅱmuscle fibers between the observation group and the control group (P＞0.05).The proportion of level I muscle strength in type I muscle fiber of the observation group was lower than that of the control group,and the proportion of level Ⅳmuscle strength in type I muscle fiber in the observation group was higher than that of the control group,the differences were statistically significant (P＜0.05).The speed value,peak value,vitality value,relaxation value and work value of postpartum pelvic floor in the observation group were higher than those in the control group,the differences were statistically significant (P＜0.05).Conclusion The use of electrical stimulation rehabilitation therapy can improve postpartum pelvic floor muscle strength damage and speed up the postpartum pelvic floor muscle rehabilitation,which has high clinical value. 2021 Vol. 28 (5): 131-133-140 [Abstract] ( 42 ) HTML (31 KB)  PDF  (0 KB)  ( 8 ) 134 Effect of music intervention in hospital on brain development of premature infants LU Yong-xue HUO Hui-yi OU Jia-xin ZOU Xiao-ping ZHOU Jin-yu HE Lu-si PENG Yun-ju HUANG Xia-chun MU Jing YAN Su-fen Objective To investigate the effect of music intervention in hospital on the brain development of premature infants.Methods A total of 60 premature infants of gestational age of the mother ≤33 weeks and appropriate for gestational age admitted to the Department of Neonatology of the First People′s Hospital of Foshan City from April 2017 to April 2018 were selected as the research subjects.They were divided into observation group and control group by random odd-even number table method,with 30 cases in each group.The preterm infants in both groups received routine treatment.On this basis,the control group used conventional nursing intervention.The observation group was treated with inpatient music intervention on the basis of conventional nursing.The average frequency of amplitude-integrated electroencephalogram was compared between the two groups.Burdjalov scores of the two groups were compared at 1,2 and 3 weeks after intervention.The lengths of sleep-wake cycle were compared between the two groups at different corrected gestational ages (corrected gestational age 33～＜35,35～＜37,37～38 weeks).Gesell scores at 24 months of correction were compared between the two groups.The normal rate of hearing screening (transient induced otoacoustic emission,auditory brainstem response) was compared between the two groups at discharge.Results There was no statistical significance in the average frequency of amplitude-integrated electroencephalogram between the two groups (P＞0.05).The scores of sleep-wake cycle,bandwidth Burdjalov scores and Burdjalov total score of the two groups at the second and third week of intervention were higher than those at the first week of intervention,with statistically significant differences (P＜0.05).The Burdjalov scores of electroencephalogram continuity and lower boundary amplitude of the two groups at the second and third week of intervention were not significantly different from those at the first week of intervention (P＞0.05).The scores of sleep-wake cycle Burdjalov score and Burdjalov total score in the observation group at the second week after intervention were higher than those in the control group,with statistically significant differences (P＜0.05).There were no significant differences in Burdjalov scores of electroencephalogram continuity,lower boundary amplitude and bandwidth between the two groups at the second week after intervention (P＞0.05).At the first and third week of intervention,there were no significant differences in scores of sleep-wake cycle,electroencephalogram continuity,lower boundary amplitude,bandwidth Burdjalov scores and Burdjalov total score between the two groups (P＞0.05).The sleep-wake cycle lengths of corrected gestational age 33-＜35,35-＜37 and 37-38 weeks in the observation group were shorter than those in the control group,and the differences were statistically significant (P＜0.05).The intelligent development quotient score of personal-social Gesell assessment of the observation group at 24 months of correction was higher than that of the control group,and the difference was statistically significant (P＜0.05).There was no significant difference between the two groups in the intelligent development quotient level of personalsocial Gesell assessment at 24 months of correction (P＞0.05).There was no significant difference in the normal rate of hearing screening (transient induced otoacoustic emission,auditory brainstem response) between the two groups at discharge (P＞0.05).Conclusion Music intervention during hospitalization can promote the brain development and maturation of premature infants in the short term,but the long-term effect needs to be further observed. 2021 Vol. 28 (5): 134-140 [Abstract] ( 35 ) HTML (54 KB)  PDF  (0 KB)  ( 7 ) 141 Clinical effect of Carboxymethyl Cellulose Sodium Eye Drops combined with artificial tears in the treatment of dry eye after phacoemulsification of cataract HU Jie-lin Objective To investigate the clinical effect of Carboxymethyl Cellulose Sodium Eye Drops combined with artificial tears in the treatment of dry eye after phacoemulsification of cataract.Methods A total of 300 cataract patients with dry eyes after phacoemulsification in Jingdezhen No.1 People′s Hospital from January 2018 to January 2019 were selected as the research subjects.According to the drawing lottery method,they were divided into three groups,control group a,control group b,and observation group c,with 100 cases (100 eyes) in each group.Control group a was treated with 0.5% Levofloxacin Eye Drops before surgery,and Tobramycin and Dexamethasone Eye Drops early after surgery (2 weeks).On this basis,control group b was treated with Carboxymethyl Cellulose Sodium Eye Drops after surgery,and observation group c was treated with artificial tears and Carboxymethyl Cellulose Sodium Eye Drops before and after surgery.Dry eye symptom score,corneal fluorescence staining score,tear break-up time (BUT) score and treatment effect of the three groups were compared.Results The dry eye symptom score and corneal fluorescence staining score of observation group c and control group b at three months after surgery were lower than those at 7 d after surgery,and the BUT score was higher than that at 7 d after operation,the dry eye symptom scores and corneal fluorescence staining scores of observation group c and control group b at 7 d,1 month,and 3 months after surgery were lower than those of control group a,while BUT score was higher than that of control group a,and the differences were statistically significant (P＜0.05).The total effective rate of observation group c and control group b was higher than that of control group a,and the total effective rate of observation group c was higher than control group b,the differences were statistically significant (P＜0.05).Conclusion The application of Carboxymethyl Cellulose Sodium Eye Drops and artificial tears after phacoemulsification of cataracts has remarkable therapeutic effects with high safety.It is worthy of exploration and promotion. 2021 Vol. 28 (5): 141-143-147 [Abstract] ( 42 ) HTML (31 KB)  PDF  (0 KB)  ( 7 ) 144 Clinical effect of combined application of Duraphat in the treatment of caries in deciduous molars after filling with flowing resin SONG Xin-hua Objective To explore the clinical effect of combined application of Duraphat in the treatment of caries in deciduous molars after filling with flowing resin.Methods A total of 90 cases of caries children who admitted to Pingxiang Maternal and Child Health Hospital of Jiangxi Province from January to March 2019 were selected as the research objects and divided into the control group and the observation group according to the random number table method,with 45 cases in each group.The control group used flow resin filling,and the observation group used fluid resin filling+Duraphat smearing.The success rate of filling and complication rate between the two groups were compared.Results There were no statistically significant differences between the two groups in the success rate of filling and the incidence of poor color stability after filling for 1 year (P＞0.05).The incidence of dental morphology abnormalities,chalk stains which were caused by enamel demineralization,secondary caries and total incidence of complications in the observation group were lower than those in the control group,and the differences were statistically significant (P＜0.05).Conclusion After filling with flowable resin,combined the application of Duraphat in the treatment of deciduous molar tooth caries has better effect.It can significantly reduce the incidence of complications after mobile resin filling,and has a high clinical value. 2021 Vol. 28 (5): 144-147 [Abstract] ( 37 ) HTML (31 KB)  PDF  (0 KB)  ( 7 ) 148 Clinical effect of Huoxue Mingmu Decoction Invigorate in the treatment of nonproliferative diabetic retinopathy YU Ji-jie；KANG Bin；WAN Jin-lan Objective To investigate the clinical effect of Huoxue Mingmu Decoction Invigorate in the treatment of nonproliferative diabetic retinopathy (NDPR).Methods A total of 80 patients with NDPR who admitted to Jingmen Hospital of Traditional Chinese Medicine in Hubei Province from June 2017 to July 2018 were selected as the research objects and divided into the control group and the observation group by random draw method,with 40 cases in each group.The control group was treated with Calcium Dobesilate Capsules,the observation group was treated with Huoxue Mingmu Decoction Invigorate.Patients in both groups were treated for 1 month.The total effective rate,the indicators of fundus lesions and the incidence of adverse reactions before and after treatment were compared between the two groups.Results The total effective rate of the observation group (87.5%) was higher than that of the control group(62.5%),and the difference was statistically significant (P＜0.05).After treatment,the volume of fundus microangioma,hemorrhagic plaque and macular thickness in the observation group were lower than those in the control group,and the differences were statistically significant (P＜0.05).There were no adverse reactions in both groups during and after treatment.Conclusion The clinical efficacy of Huoxue Mingmu Decoction Invigorate in the treatment of NDPR is better than Calcium Dobesilate Capsules. 2021 Vol. 28 (5): 148-150-154 [Abstract] ( 48 ) HTML (31 KB)  PDF  (0 KB)  ( 9 ) 151 Clinical effect of one-time root canal in the treatment of cracked teeth with pulpal lesions and quality of life analysis YAN Jie-wen；LIU Wei-hong；ZENG Bi-zhen Objective To investigate the clinical effect of one-time root canal in the treatment of cracked teeth with pulpal lesions.Methods A total of 128 patients with cracked teeth and pulp lesions who admitted to Fuyong People′s Hospital of Bao′an District in Shenzhen from June 2018 to June 2019 were selected as research objects and divided into the treatment group and the control group according to coin tossing method,with 64 cases in each group.The treatment group used one-time root canal treatment,and the control group used traditional dental treatment.The efficacy,symptom score,quality of life score and satisfaction were compared between the two groups.Results The total effective rate of the treatment group was higher than that of the control group,and the difference was statistically significant (P＜0.05).Before treatment,there were no statistically significant differences in the symptom score and quality of life score between the two groups (P＞0.05).After treatment,the symptom scores of the two groups were lower than those before treatment,the quality of life scores of the two groups were higher than those before treatment,and the differences were statistically significant (P＜0.05).After treatment,the symptom score of the treatment group was lower than that of the control group,the quality of life score of the treatment group was higher than that of the control group,and the differences were statistically significant (P＜0.05).The satisfaction score of the treatment group ([89.22±15.93]points) was higher than that of the control group ([55.34±10.19]points),and the difference was statistically significant (P＜0.05).Conclusion The one-time root canal treatment of cracked teeth with pulpal lesions has a significant therapeutic effect,which can effectively relieve patients′ symptoms,reduce pain,improve patients′ satisfaction and quality of life,and can be clinically promoted and applied. 2021 Vol. 28 (5): 151-154 [Abstract] ( 52 ) HTML (35 KB)  PDF  (0 KB)  ( 7 ) 155 Changes and significance of intraocular pressure during cardiopulmonary bypass and selective cerebral perfusion TANG Yu1 GAO Feng2▲ BAI Jing1 GUO Tao1 HE Xue-zhi2 ZHUANG Xi-jing2 DING Xue-qian3 Objective To observe the changes of intraocular pressure with different temperature and blood pressure during cardiopulmonary bypass,selective cerebral perfusion and recovery of circulation.Methods Patients who diagnosed of Type A Aortic Dissection with surgical indications underwent ascending aorta replacement and aortic arch replacement combined with frozen elephant trunk surgery in Dalian Municipal Central Hospital from December 2018 to September 2020 were selected as the research objects.General situations were recorded.Intraocular pressure during the operation cooling process,selective cerebral perfusion process,circulation recovery process and rewarming were measured and analyzed.Results A total of 21 patients were observed,including 15 males (71.4%) and 6 females (28.6%).All patients had a history of hypertension and without family history of glaucoma.There was no obvious abnormality in ophthalmic examination before and after operation.During the cooling process,the differences of intraocular pressure at different temperature points were statistically significant (P＜0.05),and intraocular pressure decreased with the lowing of temperature.During the rewarming process,the differences of intraocular pressure at each temperature points were statistically significant (P＜0.05),and intraocular pressure showed an upward trend with the increase of temperature.During the selective cerebral perfusion process,intraocular pressure showed a downward trend with the extension of time,and there was no difference between 5 minutes and 10 minutes of cerebral perfusion (P＞0.05),and in other points,the differences were statistically significant (P＜0.05).Intraocular pressure increased with time during the recovery of circulation,and the differences in each points were statistically significant (P＜0.05).Conclusion Temperature and blood pressure can affect intraocular pressure.Intraocular pressure is positively correlated with temperature and blood pressure. 2021 Vol. 28 (5): 155-158-162 [Abstract] ( 48 ) HTML (38 KB)  PDF  (0 KB)  ( 6 ) 159 Application value of awarding policy oriented intervention in treatment of children with deciduous teeth caries HE Jia Objective To explore the application value of awarding policy oriented intervention in treatment of children with deciduous teeth caries.Methods A total of 168 children with deciduous dental caries admitted to the Department of Pediatric Dentistry of Dalian Stomatological Hospital from January to May 2020 were selected as the research subjects.According to random number table,they were divided into observation group (84 cases) and control group (84 cases).The control group received non-traumatic repair surgery and routine nursing intervention,and the observation group was given reward-oriented intervention based on this basis,both groups were treated for 4 weeks.The treatment effect,treatment cooperation,treatment time,postoperative visual analogue scale (VAS) score and total nursing satisfaction of family members were compared between the two groups.Results The total effective rate and total cooperation degree of treatment in the observation group were higher than those in the control group,the treatment time was shorter than that in the control group,the pain VAS score was lower than that in the control group,and the total satisfaction of nursing in the observation group was higher than that in the control group,the differences were statistically significant(P＜0.05).Conclusion Awarding policy oriented intervention can achieve significant effect in children with deciduous teeth caries,which can effectively improve the children′s treatment compliance and shorten the treatment time.Besides,it is conductive to the development of harmonious nurse-patient relationship. 2021 Vol. 28 (5): 159-162 [Abstract] ( 49 ) HTML (35 KB)  PDF  (0 KB)  ( 6 ) 163 Effect of periodontal combined with pulp in the treatment of severe periodontitis LI Kun Objective To explore the effect of periodontal combined with pulp in the treatment of severe periodontitis.Methods A total of 112 patients with severe periodontitis admitted to Fushun Hospital of Chinese Medicine from October 2017 to June 2018 were selected as research objects.According to the random number table method,they were divided into the experimental group (58 cases) and the control group (54 cases).The experimental group was treated with periodontal combined with pulp,while the control group was treated with periodontal alone.The total effective rate,gingival creval bleeding index (SBI),degree of tooth loosening (TM),periodontal probing depth (PD),plaque index(PLI),loss of attachment (CAL) before and after treatment,and the incidence of complications were compared between the two groups.Results The total effective rate of treatment in the experimental group was higher than that in the control group,and the difference was statistically significant (P＜0.05).Before treatment,there were no significant differences in SBI,TM,PD,PLI and CAL between the two groups (P＞0.05).At 6 months after treatment,SBI,TM,PD and PLI of the two groups were lower than those before treatment,and CAL was higher than that before treatment.SBI,TM,PD and CAL in the experimental group were lower than those in the control group,and the differences were statistically significant (P＜0.05).There was no significant difference in PLI between the two groups (P＞0.05).The total incidence of complications in the experimental group was lower than that in the control group,the difference was statistically significant (P＜0.05).Conclusion Periodontal combined with pulp in the treatment of severe periodontitis has better clinical efficacy than traditional methods,which can fundamentally improve the pulp condition of patients and improve the prognosis.Early pulp treatment can significantly improve the treatment efficiency. 2021 Vol. 28 (5): 163-165 [Abstract] ( 45 ) HTML (28 KB)  PDF  (0 KB)  ( 8 ) 166 Effect of intraocular lens implantation in the treatment of high myopia ZHANG Rui；ZHANG Qiao-si；LIANG Wei；YU Chun-jing Objective To explore the clinical effect of intraocular lens implantation in the treatment of high myopia.Methods A total of 80 patients with high myopia admitted to Dalian Third People′s Hospital from March 2017 to June 2019 were selected,and divided into the observation group and the control group according to random number table method,with 40 patients in each group.The observation group was treated with posterior chamber intraocular lens (ICL),the control group was treated with full femtosecond laser micro-incision corneal stroma lens resection (SMILE).At 1 year after surgery,lens high-order aberrations and whole-eye high-order aberrations at 3 mm and 5 mm pupil diameters,corneal endothelial cell density before and after surgery,visual acuity changes during 1 year follow-up were compared between the two groups.Results At 1 year after operation,the higher-order aberrations of lens in observation group were lower than those in control group at 3 mm and 5 mm pupil diameters,the differences were statistically significant(P＜0.05).The density of corneal endothelial cells in observation group was higher than that in control group,the difference was statistically significant (P＜0.05).One month,six months and one year after operation,the visual acuity in observation group was higher than that in control group,the difference was statistically significant (P＜0.05).Conclusion For patients with high myopia,ICL implantation can effectively reduce postoperative high-order aberrations,improve corneal endothelial cell function and improve postoperative visual acuity. 2021 Vol. 28 (5): 166-168 [Abstract] ( 47 ) HTML (32 KB)  PDF  (0 KB)  ( 7 ) 169 Influence of rigid disposcope-guided tracheal intubation on bispectral index and hemodynamics in obese patients XU Chun-cheng Objective To analyze the influence of rigid disposcope-guided tracheal intubation on bispectral index (BIS)and hemodynamics in obese patients.Methods A total of 100 cases of obese patients who need surgical treatment in People′s Hospital of Puning City from March 2019 to April 2020 were selected as the research objects,and they were divided into the control group (n=50) and the observation group (n=50) according to random number table method.The control group was given Macintosh direct laryngoscope to guide tracheal intubation,and the observation group was given rigid disposcope to guide tracheal intubation.The changes of BIS and hemodynamics were compared between the two groups.Results The BIS of the control group after tracheal intubation was higher than that before tracheal intubation,and the BIS of the observation group after tracheal intubation was lower than that of the control group,the differences were statistically significant (P＜0.05).There was no significant difference in the BIS of the observation group before and after tracheal intubation (P＞0.05).The mean arterial pressure (MAP) and heart rate (HR) of the patients in the control group after tracheal intubation were higher than those before the tracheal intubation,and the MAP and HR of the patients in the observation group after tracheal intubation were lower than those in the control group,the differences were statistically significant (P＜0.05).There were no statistically significant difference between MAP and HR before and after tracheal intubation (P＞0.05).Conclusion In obese patients,the effect of using rigid disposcope for tracheal intubation is significant,which is better than that of the Macintosh direct laryngoscope.It effectively controls and stabilizes the BIS and hemodynamics,and which is worthy of popularization and application. 2021 Vol. 28 (5): 169-171 [Abstract] ( 42 ) HTML (28 KB)  PDF  (0 KB)  ( 7 ) 172 Effect of Sevoflurane intravenous inhalation combined anesthesia on the immune function and hemodynamics of patients with cervical cancer GE Yu-ting Objective To analyze the effect of Sevoflurane intravenous inhalation combined anesthesia on the immune function and hemodynamics of patients with cervical cancer.Methods A total of 54 patients with cervical cancer admitted to Maternal and Child Health Hospital of Dalian Jinpu New District from April 2017 to April 2020 were selected as the research objects.According to the random number table method,they were divided into a control group(27 cases)and an experimental group (27 cases).Patients in the control group were treated with Propofol continuous anesthesia,and patients in the experimental group were treated with Sevoflurane intravenous inhalation combined anesthesia.The perioperative immune function levels,serum nerve growth factor (NGF),brain-derived neurotrophic factor (BDNF) levels and hemodynamic levels in different time periods were compared between the two groups of patients.Results The levels of CD4+CD25+T and CD4+OX40+T in the two groups at 48 hours after operation were lower than those before operation,the differences were statistically significant(P＜0.05); and the levels of CD4+CD25+T and CD4+OX40+T in the experimental group at 48 hours after operation were lower than those in the control group,the differences were statistically significant (P＜0.05).The levels of NGF and BDNF at 48 hours after operation were lower than those before operation,the differences were statistically significant (P＜0.05); and the levels of NGF and BDNF in the experimental group at 48 hours after operation were higher than those in the control group,the differences were statistically significant (P＜0.05).There were no significant differences in heart rate (HR),mean arterial pressure (MAP),blood oxygen saturation(SpO2) between the two groups at 5 minutes before anesthesia (P＞0.05); at 5 minutes after anesthesia and the beginning of the operation,the HR and MAP of the experimental group were lower than those of the control group,and SpO2 was higher than that of the control group,the differences were statistically significant (P＜0.05).Conclusion Sevoflurane intravenous inhalation combined anesthesia is used for the surgical treatment of cervical cancer,it helps to reduce immune response and maintain hemodynamic stability. 2021 Vol. 28 (5): 172-174-178 [Abstract] ( 43 ) HTML (34 KB)  PDF  (0 KB)  ( 7 ) 175 Application effect of Dexmedetomidine combined with Etomidate in painless gastrointestinal endoscopy and its influences on stress response in the elderly ZHAO Jing Objective To explore the application effect of Dexmedetomidine combined with Etomidate in painless gastrointestinal endoscopy and its influences on stress response in the elderly.Methods A total of 92 elderly patients undergoing gastrointestinal endoscopy in Huludao Central Hospital from May 2018 to May 2019 were selected as the research subjects.The control group was given Etomidate,while observation group was given Dexmedetomidine combined with Etomidate for anesthesia.The levels of cortisol (Cor),aldosterone (ALD),angiotensin Ⅱ(AT-Ⅱ) before examination,after 5 minutes of examination and at 1 hour after examination,recovery time of spontaneous breathing,recovery time and extubation time after withdrawal,scores of Ramsay sedation and visual analogue scale (VAS) at 1 hour after examination,and the occurrence of adverse reactions during examination were compared between the two groups.Results The levels of stress indicators in the observation group were lower than those in the control group at 5 min and 1 hour after examination,and the differences were statistically significant (P＜0.05).At 1 hour after the examination,Ramsay sedation score in the observation group was higher than that in the control group,VAS score was lower than that in the control group,the differences were statistically significant (P＜0.05).During the examination,the total incidence of adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant (P＜0.05).Conclusion The application of Dexmedetomidine combined with Etomidate in elderly painless gastroenteroscopy can play a better sedative and analgesic effect,and alleviate the stress response of patients and reduce the incidence of adverse reactions. 2021 Vol. 28 (5): 175-178 [Abstract] ( 42 ) HTML (32 KB)  PDF  (0 KB)  ( 9 ) 179 Clinical application value of CT coronary angiography in the diagnosis of coronary heart disease TAN Shan-ling Objective To explore the clinical value of CT coronary angiography in the diagnosis of coronary heart disease.Methods A total of 350 patients suspected with coronary heart disease admitted to the First People′s Hospital of Huizhou City from May to October 2019 were selected as study subjects,and all underwent CT coronary imaging and angiography.The results of coronary angiography were taken as the gold standard to analyze the clinical application value of CT coronary angiography.Results The sensitivity,specificity and accuracy of CT coronary angiography were 99.04%,94.44% and 98.57%.There were no significant differences in the detection rates of left main coronary artery,left anterior descending artery,left circumflex artery,right coronary artery and indications of stent or bypass grafting between CT coronary angiography and coronary angiography (P>0.05).There were no significant differences in the detection rate of occlusion,severe stenosis,moderate stenosis,mild or normal stenosis between CT coronary angiography and coronary angiography (P>0.05).Conclusion The effect of CT coronary angiography in the diagnosis of coronary heart disease is exact and has important clinical application value. 2021 Vol. 28 (5): 179-181 [Abstract] ( 51 ) HTML (29 KB)  PDF  (0 KB)  ( 5 ) 182 Application value of multi-parameter magnetic resonance imaging in the differential diagnosis of uterine carcinosarcoma and low-risk endometrial cancer LIU Jing Objective To evaluate the clinical application value of multi-parameter magnetic resonance imaging (MRI)in the differential diagnosis of uterine carcinosarcoma (CS) and low-risk endometrial cancer (EC).Methods Retrospectively,20 patients with CS and 20 patients with low-risk EC admitted to Benxi Central Hospital from March to November 2019 were selected as CS group and low-risk EC group,respectively,the condition of MRI examinations was compared between the two groups.Results The number of cystic degeneration/necrosis,hemorrhage,and vascular flow void shadows in CS patients were higher than those in low-risk EC patients,the differences were statistically significant (P＜0.05).There were no significant differences in apparent diffusion coefficient (ADC) and relative apparent diffusion coefficient (rADC) between CS patients and low-risk EC patients (P＞0.05).The maximum tumor diameter,the ratio of intrauterine thickness to uterine diameter (ETAP) and the maximum relative enhancement rate (MRER) in CS patients were higher than those in low-risk EC patients,while the Washout rate was lower than that in low-risk EC patients (P＜0.05).Receivers operating characteristic (ROC) curve showed that the area under the maximum diameter curve (AUC)of the tumor was 0.877,ETAP AUC was 0.906,and MRER AUC was 0.979.The sensitivity and specificity were the highest when the maximum diameter of the tumor was 38.2 mm,ETAP was 0.479,and MRER was 1.300.Conclusion In the diagnosis of CS and low-risk EC,the maximum diameter of tumor,ETAP and MRER in MRI examination can be used for differential diagnosis. 2021 Vol. 28 (5): 182-184-188 [Abstract] ( 43 ) HTML (32 KB)  PDF  (0 KB)  ( 7 ) 185 Value comparison of CT and MRI in the diagnosis of meniscus and articular cartilage injury LIU Dong-xiong；TANG Wen-tao；CAI Bi-hong Objective To compare the diagnostic value of CT and MRI in patients with knee meniscus and articular cartilage injury.Methods A total of 78 patients suspected with meniscus and articular cartilage injuries of knee joints admitted to the Second Traditional Chinese Medicine Hospital of Meizhou City from March 2017 to September 2019 were selected as the research objects.All patients underwent CT and MRI examination of the knee joint,and the results of arthroscopy were taken as the gold standard.The accuracy of CT and MRI in the diagnosis of meniscal injury and articular cartilage injury was observed,and the sensitivity and specificity of CT and MRI in the diagnosis of meniscal injury and articular cartilage injury were calculated.Results Among 78 patients,72 patients with meniscus injury and articular cartilage injury were detected by arthroscopy.The accuracy rate of MRI in meniscus injury (94.44%) was higher than that of CT (83.33%),the difference was statistically significant (P＜0.05).The accuracy of MRI (95.83%) in diagnosing articular cartilage injury was higher than that of CT (86.11%),the difference was statistically significant (P＜0.05).The sensitivity and specificity of MRI in the diagnosis of meniscus and articular cartilage injuries were higher than those of CT,the differences were statistically significant (P＜0.05).Conclusion For patients with meniscus and articular cartilage injury of knee joint,the sensitivity and specificity of MRI examination are higher than those of CT examination,the diagnostic accuracy of MRI examination is comparable to that of arthroscopy,which is worthy of clinical promotion. 2021 Vol. 28 (5): 185-188 [Abstract] ( 44 ) HTML (36 KB)  PDF  (0 KB)  ( 7 ) 189 Value of early diagnosis of transperineal four-dimensional ultrasound for postpartum stress urinary incontinence LYU Zhi-ru；WANG Xiao-dan；LIU Wei Objective To explore the value of transperineal four-dimensional ultrasound in the early diagnosis of postpartum stress urinary incontinence.Methods A total of 42 patients with postpartum stress urinary incontinence admitted to Dalian Maternal and Child Health Hospital from May 2017 to April 2020 were selected retrospectively as the study group,and 40 cases of maternal women without postpartum stress urinary incontinence during the same period were selected as the control group.At 42 days after delivery,all the women underwent transperineal four-dimensional ultrasound examination in resting and Valsalva state.The distance of bladder neck movement,parameters of bladder and urethra measured by ultrasound at rest and in Valsalva actions were compared between the two groups.Results The bladder neck mobility of the study group was higher than that of the control group,and the difference was statistically significant (P＜0.05).In resting and Valsalva state,the vertical distance from the bladder neck to the lower edge of the pubic symphysis in the study group was smaller than that in the control group,and the posterior bladder urethra and pelvic diaphragm area were larger than those in the control group,the differences were statistically significant (P＜0.05).Conclusion Early diagnosis of using transperineal four-dimensional ultrasound on postpartum stress urinary incontinence has important meaning.It can display the bladder neck movement and the vertical distance from the bladder neck to the pubic bone and the lower edge,clearly image the urethra and pelvis,and calculate the posterior angle and pelvic diaphragm hole are and provide the basis for the development and improvement of the further treatment plan. 2021 Vol. 28 (5): 189-191-195 [Abstract] ( 49 ) HTML (31 KB)  PDF  (0 KB)  ( 5 ) 192 Chief physician Chen Xin-yu′s experience in treatment of chronic liver disease based on the theory of qi and blood ZHAO Xue-jun；XIA Li；LUO Ben-qing；CHEN Xin-yu Chief physician Chen Xin-yu is the third batch of academic heirs in the country,under the tutelage of the chief physician Luo Ben-qing,who is a famous and old traditional Chinese medicine (TCM) physician in Chongqing.Chen Xin-yu has engaged in hepatobiliary disease research for many years and has rich experience in clinical treatment of chronic liver disease.This paper summarizes her experience in the treatment of chronic hepatitis B complicated with non-alcoholic fatty liver disease.Chen Xin-yu considered that the pathological changes of the relationship between viscera,qi and blood,which penetrated the whole course of disease,and she summarized the basic pathogenesis of "disharmony of blood qi".She emphasized etiological treatment and focused on restoring the normal relationship between viscera,qi and blood in the clinical treatment.Based on this theory of qi and blood,she put forward to treat principle of "reconciling qi and blood,dispelling evil and relieving viscera".According to the severity of the disease,she takes medication in stages and levels.At the same time,she pays attention to protecting the vital qi and the function of the visceral function. 2021 Vol. 28 (5): 192-195 [Abstract] ( 51 ) HTML (36 KB)  PDF  (0 KB)  ( 6 ) 196 Effect of traditional Chinese medicine colon dialysis on the micro-inflammation and nutritional status of patients with stage 3 ～5 chronic kidney disease LEI Bing;YANG Tai-wang;HUANG Hong-en;LI Jing Objective To investigate the effect of traditional Chinese medicine colonic dialysis on the micro-inflammatory and nutrition status of patients with stage 3～5 chronic kidney disease (CKD).Methods A total of 60 patients with stage 3～5 CKD who were admitted to Jiujiang Hospital of Traditional Chinese Medicine in Jiangxi Province from January 2016 to December 2017 were selected as the research objects and divided into the control group and the treatment group according to the random number table method,with 30 cases in each group.The control group was treated with traditional Chinese medicine enema,while the treatment group was treated with traditional Chinese medicine colon dialysis,and both of the groups were treated for 3 months.The inflammation indicators and nutritional status of the two groups were compared.Results After 3 months of treatment,the levels of serum high-sensitivity C-reactive protein(hs-CRP),interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in the two groups were lower than those before treatment,and the levels of hs-CRP,IL-6 and TNF-α in the treatment group were lower than those in the control group,the differences were statistically significant (P＜0.05).After 3 months of treatment,the levels of plasma albumin,transferrin,plasma prealbumin and hemoglobin in the two groups were higher than those before treatment,and the levels of plasma albumin,transferrin,plasma prealbumin and hemoglobin in the treatment group were higher than those in the control group,the differences were statistically significant (P＜0.05).Conclusion The traditional Chinese medicine colon dialysis is effective in the treatment of patients with stage 3～5 CKD,which can further reduce the micro-inflammatory reaction and improve the nutritional status. 2021 Vol. 28 (5): 196-198-202 [Abstract] ( 46 ) HTML (33 KB)  PDF  (0 KB)  ( 6 ) 199 Clinical experience of Wenjing Decoction in treatment of dermatopathy identified as cold and heat complex LIU Yang；WU Cai-xia；WANG Juan Wenjing Decoction derives from the Chapter Miscellaneous Diseases in Women in Essentials from the Golden Cabinet written by ZHANG Zhong-jing.The original formula is mainly used to treat many gynecological diseases caused by deficiency cold of the thoroughfare and conception vessels.Later generations of physicians applied flexibly on the basis of inheritance,for all diseases due to deficiency cold of thoroughfare and conception vessels,internal obstruction of blood stasis,or yang deficiency with lack of warmth,and blood-cold stagnation,regardless of the length of the disease,the severity of the disease,or the depth of the disease,favorable effect can be obtained as long as the pathogenesis is the same.During clinical observation,we found that clinical application of modified Wenjing Decoction to treat the refractory skin diseases with the types of deficiency cold of thoroughfare and conception vessels and blood-cold stagnation is effective,so we collected the empirical cases and searched literature,and summarized the rules of applying Wenjing Decoction,to provide more ideas for future clinical treatment. 2021 Vol. 28 (5): 199-202 [Abstract] ( 43 ) HTML (34 KB)  PDF  (0 KB)  ( 7 ) 203 Clinical effect of modified Simiao Powder combined with retroperitoneoscopic ureterolithotomy in the treatment of upper ureteral incarcerated calculi with empyema SHEN Si-yao；ZENG Xiao-chun；ZHAO Hong；LI Jian-min；RAO Pin-lang；XIONG Jun-hui Objective To explore the effect of retroperitoneoscopic ureterolithotomy (RPUL) combined with modified Simiao Powder in the treatment of upper ureteral incarcerated calculi with empyema.Methods The clinical data of 80 patients with upper ureteral incarcerated calculi and empyema in Jiangxi Hospital of Integrated Traditional Chinese and Western Medicine from January 2016 to April 2020 were retrospectively analyzed and they were divided into group A (modified Simiao Powder+RPUL treatment,28 cases),group B (Paishi Granules+RPUL treatment,26 cases) and group C (RPUL treatment,26 cases) according to different treatment methods.The levels of serum procalcitonin (PCT),urinary white blood cell (U-WBC) and red blood cell count (RBC) at 1 week after surgery,the number of days of body temperature over 38.5℃after surgery,extubation time and visual analogue scale (VAS) score of the three groups were compared.Results The serum PCT,U-WBC and RBC levels of group A at 1 week after surgery were lower than those of group B and C,and the serum PCT,U-WBC and RBC levels of group B were lower than those of group C,the differences were statistically significant (P＜0.05).The number of days of body temperature over 38.5℃after surgery and the extubation time in group A were shorter than those in group B and C,and the VAS score was lower than that in group B and C; and the number of days of body temperature over 38.5℃and the extubation time in group B were shorter than those in group C,and the VAS score was lower than that in group C,the differences were statistically significant (P＜0.05).Conclusion The RPUL combined with modified Simiao Powder in the treatment of upper ureteral incarcerated calculi with empyema has better effect,which can effectively reduce serum PCT,U-WBC and RBC levels,and relieve pain of patients. 2021 Vol. 28 (5): 203-205-210 [Abstract] ( 33 ) HTML (31 KB)  PDF  (0 KB)  ( 6 ) 206 Clinical effect of Fuzheng Huazhuo Decoction in the treatment of elderly patients with drug-resistant bacteria pneumonia qi deficiency phlegm turbidity obstructing lung syndrome GAO Yuan；LIU Hao；MU Xiao-jing；QU Ni-ni；QIN Yi-bing Objective To explore the clinical effect of Fuzheng Huazhuo Decoction in the treatment of elderly patients with drug-resistant bacteria pneumonia qi deficiency phlegm turbidity obstructing lung syndrome.Methods A total of 60 elderly patients with drug-resistant pneumonia (qi deficiency phlegm turbidity obstructing lung syndrome) admitted to Dalian Traditional Chinese Medicine Hospital from October 2017 to May 2019 were selected as the research objects and divided into the treatment group and the control group according to random number table method,with 30 cases in each group.The control group was treated by routine western medicine treatment,and the treatment group was treated by Fuzheng Huazhuo Decoction on the basis of the treatment of the control group.After treatment,the antibiotic resistance bacteria clearance rate,clinical pulmonary infection score (CPIS),inflammatory indicators (tumor necrosis factor-α[TNF-α],high mobility group box 1 protein[HMBG-1],and interleukin-10[IL-10])were compared between the two groups.Results There was no statistically significant difference in the clearance rate of drug-resistant bacteria between the two groups (P＞0.05).The clinical pulmonary infection score(CPIS) of the treatment group was lower than that of the control group,and the difference was statistically significant (P＜0.05).The serum levels of TNF-α and HMBG-1 in the treatment group were lower than those in the control group,and the differences were statistically significant (P＜0.05).The serum level of IL-10 in the treatment group was higher than that in the control group,and the difference was statistically significant (P＜0.05).Conclusion The anti-infective effect of the treatment of elderly drugresistant bacteria pneumonia qi deficiency phlegm turbidity obstructing lung syndrome with Fuzheng Huazhuo Decoction on the basis of the conventional western medicine,and it has a positive and effective role in clearing inflammatory mediators. 2021 Vol. 28 (5): 206-210 [Abstract] ( 45 ) HTML (41 KB)  PDF  (0 KB)  ( 6 ) 211 Analysis of reasons,influencing factors and countermeasures study of irrational use of drugs in outpatient prescriptions GONG Jun；WU Jian-e Objective To explore the reasons,influencing reasons and countermeasures of irrational use of drugs in outpatient prescriptions.Methods A total of 240 prescriptions from the numerous prescriptions issued by physicians in the outpatient departments of Gao′an People′s Hospital in Jiangxi Province from December 2016 to March 2019 were randomly selected for this experimental study.The relevant staff involved in this study used a retrospective analysis method to objectively count the proportion of irrational drug prescriptions in 240 outpatient prescriptions based on the Prescription Management Method,comprehensively analyze the types and reasons of irrational drug prescriptions,and completed univariate and multivariate Logistic analysis.Results Among the 240 outpatient prescriptions,there were 30 unreasonable prescription drugs,and the unreasonable drug use rate accounted for 8.00%.The univariate results showed that there was no statistically significant difference in the incidence of irrational outpatient prescriptions under different solvent choices (P＞0.05).There was statistically significant difference in the incidence of unreasonable outpatient prescriptions under administration methods,drug selection,medication interval,combination medication,and medication frequency (P＜0.05).The results of multivariate Logistic analysis showed that the method of administration,drug selection,medication interval,combination medication,and medication frequency were the risk factors for irrational medication use in outpatient prescriptions (P＜0.05).Conclusion There are many factors affecting the unreasonable use of drugs in hospital outpatient prescriptions,such as unreasonable drug administration and unreasonable drug selection.Different factors can interact and affect each other.Relevant hospital departments should further promote the drug system implementation,while focusing on continuously improving the comprehensive technical level and professional ethics of medical personnel,prompting them to be strict in their work positions,conscientious and responsible,so as to continuously improve the rationality of outpatient prescriptions. 2021 Vol. 28 (5): 211-214 [Abstract] ( 52 ) HTML (37 KB)  PDF  (0 KB)  ( 8 ) 215 Analysis of critical thinking ability and influencing factors of undergraduate nursing students from different sources PANG Xiao-li；PAN Hui-wei Objective To understand the critical thinking ability and influencing factors of nursing students from different sources and to provide objective basis for colleges and universities to make targeted training plans for different students in the future.Methods A total of 71 students in the 2018 nursing undergraduate class of Medical College of Shaoguan University (hereinafter referred to as "our school") were selected as the research objects,and the cross-sectional research method was conducted to investigate the critical thinking ability and influencing factors of the general college entrance examination and "secondary vocational college" nursing students.Results The total scores of the critical thinking disposition inventory (CTDI-CV) in the general college entrance examination and "secondary vocational college" nursing students was (246.06±19.23) and (254.93±27.44) points,respectively,in the stage of unclear significance.The cognitive maturity of undergraduates from secondary vocational students was higher than that of undergraduates from high school students,the difference was statistically significant (P＜0.05).The comparison of the cognitive maturity dimension scores of nursing students under different internship experience and gender and the self-confidence dimension score of nursing students under the condition of extracurricular reading time showed statistically significant differences (P＜0.05).Conclusion The overall level of critical thinking ability of nursing undergraduates from different sources in our school is not high,and it needs to be trained and strengthened in follow-up teaching. 2021 Vol. 28 (5): 215-219 [Abstract] ( 43 ) HTML (36 KB)  PDF  (0 KB)  ( 8 ) 220 A survey of cognition and influence factors of human papilloma virus and its preventive vaccines among college students in Guangzhou ZHU Jiu-xiao；CAI Wen-qing；GUO Gang-sheng；CHEN Jia-qi；HU Cheng-yuan；BAI Li-ping Objective To understand the awareness of human papilloma virus (HPV) and its vaccines among college students in Guangzhou,analyze the influencing factors,and provide relevant suggestions for the popularization of vaccines.Methods The multi-stage sampling method was used,and a total of 1226 students from ten universities in Guangzhou were selected in December 2018.A single factor and binary Logistic regression analysis were applied to explore the factors that affected college students′ cognition of HPV and HPV vaccines.Results The awareness rate of HPV vaccine among college students was 70.15%,and the percentages of people who correctly answered the validity period,the effective objects,the process,the requirements and the suitable objects of HPV vaccines accounted for 25.1%,43.4%,33.4%,26.6% and 25.4% of the overall survey respondents,respectively.Hence,the data showed that college students had low specific knowledge of vaccines.Females,medical majors,and college students with urban household registration,higher grades and high monthly living expenses were more aware of HPV vaccines,and they also knew more about HPV and its preventive vaccines (P＜0.05).Conclusion Most college students are aware of the HPV vaccine,but there are cognitive biases and are affected by multi-dimensional factors.New media,family and friends are the main ways to gain awareness.Hence,it is necessary to make good use of new media,classify the population,and strengthen the popularization of science for the knowledge-less people and areas that are undervalued. 2021 Vol. 28 (5): 220-223 [Abstract] ( 64 ) HTML (32 KB)  PDF  (0 KB)  ( 8 ) 224 Application effect of early rehabilitation nursing intervention management in high risk with cerebral palsy WANG Chun-yu Objective To explore application effect of early rehabilitation nursing intervention management in high risk with cerebral palsy.Methods The 60 cases of cerebral palsy high-risk infants in Shenyang Children′s Hospital from April 2019 to July 2020 were selected as study objects,they were divided into the control group and the observation group by random slip method,30 cases in each group.Routine rehabilitation nursing intervention was given the control group,rehabilitation nursing intervention management in early stage was given the observation group.The neurodevelopment score,development score,bayley scales of infant development,denver model scales of children in the two group before and after intervention were compared.The neurodevelopment score,development score,bayley scales of infant development,denver model scales of observation group for receiving rehabilitation care management in different age were compared.Results After intervention,the neurodevelopment scores,development scores,Bayley scale scores of infant development,Denver model scale scores of control group and observation group were higher than those before intervention in the same group,neurodevelopment score,development score,Bayley scale score,Denver model scale score of infant development of observation group were higher than those in the control group,the differences were statistical significance (P＜0.05).After intervention,neurodevelopment score,development score,Bayley scale score,Denver model scale score of infant development of children in age ≤1,the differences were statistical significance (P＜0.05),but neurodevelopment score,Development score,Bayley scale score,Denver model score of infant development of children in age＞1 were compared,the differences were no statistical significance (P＞0.05),neurodevelopment score,development score,Bayley scale score,Denver model scale score of infant development of children in age ≤1 were higher than those in age ＞1,the differences were statistical significance (P＜0.05).Conclusion The cerebral palsy high-risk infants by rehabilitation nursing intervention management in early stage are favourable to recover of cerebral palsy high-risk infants neural function,which could improve cerebral nerve injury,promote growth and development,in particular age≤1 children，nursing intervention effect is good. 2021 Vol. 28 (5): 224-227 [Abstract] ( 51 ) HTML (36 KB)  PDF  (0 KB)  ( 5 ) 228 Effect of therapeutic communication combined with synchronous family health education on subjective well-being and quality of life of breast cancer patients WANG Zi-lian；NIE Cui-xia；LIANG Ming-ping Objective To explore the effect of therapeutic communication combined with synchronous family health education on subjective well-being and quality of life of breast cancer patients.Methods A total of 82 female breast cancer patients treated in Jiangmen Central Hospital,Guangdong Province from March 2018 to March 2019 were selected and divided into two groups according to random number table method,41 cases in each group.The control group was given routine nursing care,and the study group was given therapeutic communication combined with synchronous health education of family members on this basis.The observation lasted until 3 months after discharge.The negative emotions,exercise compliance,subjective well-being and quality of life were compared between the two groups.Results After nursing,the symptom checklist 90 (SCL-90) score of the study group was lower than that of the control group,the difference was statistically significant (P＜0.05); the overall well-being scale (GWB) and the quality of life of breast cancer patients (FACT-B) in the study group after nursing care were higher than those of the control group,the differences were statistically significant (P＜0.05).The exercise total compliance of the study group was 95.12%,which was higher than 80.49% of the control group,the difference was statistically significant (P＜0.05).Conclusion Therapeutic communication combined with synchronous family health education can alleviate the negative emotions of breast cancer patients,improve exercise compliance and subjective well-being,and improve the quality of life of patients. 2021 Vol. 28 (5): 228-230 [Abstract] ( 49 ) HTML (31 KB)  PDF  (0 KB)  ( 6 ) 231 Application effect of health education combined with extended nursing on patients with bronchial asthma YANG Yue Objective To explore the application effect of health education combined with extended nursing on patients with bronchial asthma.Methods A total of 100 patients with bronchial asthma admitted to Liaoning Health Industry Group Iron and Coal General Hospital from May 2018 to October 2019 were selected as the research objects.They were divided into the observation group (50 cases) and the control group (50 cases) according to the sequence of admission.The observation group adopted health education and extended nursing methods,and the control group adopted conventional nursing methods.The scores of psychological state,nursing satisfaction and quality of life were compared between the two groups.Results The scores of self-rating anxiety scale (SAS) and self-rating depression scale (SDS)scores in the observation group ([6.33±1.12],[6.85±1.01]points) were lower than those in the control group of (10.12±1.82) and (10.85±1.85) scores,the differences were statistically significant (P＜0.05).The total nursing satisfaction of the observation group was 98.00%,higher than 74.00% of the control group,the difference was statistically significant (P＜0.05).The scores of physical health,daily activity,mental health and social function scores in the observation group([95.28±1.25],[92.25±1.31],[93.25±1.01],[95.28±1.12]points) were higher than those in the control group of (80.25±1.12),(78.58±1.56),(79.25±1.45) and (80.22±1.52) points,the differences were statistically significant (P＜0.05).Conclusion The application effect of health education and extended nursing for patients with bronchial asthma is very significant.It can not only improve the negative emotions of patients,but also improve the satisfaction of patients and improve the quality of life of patients. 2021 Vol. 28 (5): 231-233 [Abstract] ( 46 ) HTML (29 KB)  PDF  (0 KB)  ( 6 ) 234 Application of psychological nursing in nursing of patients with orthopaedic limb fracture and its impact on pain LI Dong-yang；WANG Jing；YANG Xue；RONG Feng-ju；KANG Li-na；SUN Gui-fang Objective To study and analyze the application effect of psychological nursing in the nursing of patients with limb fracture and its influence on pain.Methods From June 2019 to may 2020,94 cases of limb fracture patients treated in Hongqi Hospital Affiliated to Mudanjiang Medical University were selected as the research objects,and they were divided into the control group and the observation group according to random number table method,47 cases in each group.The control group was given routine nursing,while the observation group was given psychological nursing.The visual analogue scale (VAS),self rating anxiety scale (SAS),self rating depression scale (SDS),activities of daily living Barthel index scale (BI) and satisfaction of the two groups were compared.Results Before nursing,there were no significant difference in VAS,SDS,SAS scores and BI index between the two groups (P＞0.05); after nursing,the VAS,SDS,SAS scores of the observation group were lower than those of the control group,while the BI index was higher than that of the control group,the differences were statistically significant (P＜0.05).The total satisfaction of the observation group (93.62%) was higher than that of the control group (74.47%),the difference was statistically significant (P＜0.05).Conclusion The application effect of psychological nursing is helpful to improve nursing satisfaction,relieve pain and improve life ability of patients with limb fracture. 2021 Vol. 28 (5): 234-236-240 [Abstract] ( 44 ) HTML (32 KB)  PDF  (0 KB)  ( 8 ) 237 Clinical effect of comprehensive nursing measures on prevention of hypercapnia complicated by laparoscopic radical prostatectomy LIN Cui-qin；WEI Wei；HUANG Su-zhen；CHEN Wei-zhen Objective To investigate the clinical effect of comprehensive nursing measures on prevention of hypercapnia complicated by laparoscopic radical prostatectomy.Methods A total of 55 patients treated in Foshan Hospital of Traditional Chinese Medicine for laparoscopic radical resection of prostate cancer under general anesthesia from January 2018 to Decmber 2019 were selected as study subjects,and randomly divided them into control group (n=27) and obeservation groups (n=28) by envelope method.The patients in the control group received routine basic nursing care,and patients in the observation group received targeted comprehensive nursing care during the perioperative period.The oxygen saturation (SpO2) and carbon dioxide partial pressure (PaCO2) were compared between the two groups.Results There was no significant difference in SpO2 between the two groups during the perioperative period (P＞0.05).The baseline of PaCO2 in the two groups was flat before operation,but the differences were statistically significant in the observation group during and after operation compared with the control group (P＜0.05).Hypercapnia occurred in 2 patients in the observation group,with an incidence of 7.14%,and in 7 patients in the control group,with an incidence of 25.9%,with statistically significant difference (P＜0.05).Conclusion Laparoscopic radical resection of prostate cancer is easy to be complicated with hypercapnia,and comprehensive nursing measures can effectively reduce the incidence of hypercapnia.It is worth popularizing and applying in clinical practice and operation nursing of various diseases. 2021 Vol. 28 (5): 237-240 [Abstract] ( 50 ) HTML (37 KB)  PDF  (0 KB)  ( 7 )

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