扶正化浊汤治疗老年耐药菌肺炎气虚痰浊阻肺证患者的临床效果

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Abstract Objective To explore the clinical effect of Fuzheng Huazhuo Decoction in the treatment of elderly patients with drug-resistant bacteria pneumonia qi deficiency phlegm turbidity obstructing lung syndrome.Methods A total of 60 elderly patients with drug-resistant pneumonia (qi deficiency phlegm turbidity obstructing lung syndrome) admitted to Dalian Traditional Chinese Medicine Hospital from October 2017 to May 2019 were selected as the research objects and divided into the treatment group and the control group according to random number table method,with 30 cases in each group.The control group was treated by routine western medicine treatment,and the treatment group was treated by Fuzheng Huazhuo Decoction on the basis of the treatment of the control group.After treatment,the antibiotic resistance bacteria clearance rate,clinical pulmonary infection score (CPIS),inflammatory indicators (tumor necrosis factor-α[TNF-α],high mobility group box 1 protein[HMBG-1],and interleukin-10[IL-10])were compared between the two groups.Results There was no statistically significant difference in the clearance rate of drug-resistant bacteria between the two groups (P＞0.05).The clinical pulmonary infection score(CPIS) of the treatment group was lower than that of the control group,and the difference was statistically significant (P＜0.05).The serum levels of TNF-α and HMBG-1 in the treatment group were lower than those in the control group,and the differences were statistically significant (P＜0.05).The serum level of IL-10 in the treatment group was higher than that in the control group,and the difference was statistically significant (P＜0.05).Conclusion The anti-infective effect of the treatment of elderly drugresistant bacteria pneumonia qi deficiency phlegm turbidity obstructing lung syndrome with Fuzheng Huazhuo Decoction on the basis of the conventional western medicine,and it has a positive and effective role in clearing inflammatory mediators.

Key words： Fuzheng Huazhuo Decoction Drug-resistant bacterial pneumonia in the elderly Qi deficiency phlegm turbidity obstruction lung syndrome Clearance rate of resistant bacteria Clinical pulmonary infection score Tumor necrosis factor-α Interleukin-10 High mobility group box 1 protein

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	Articles by authors
	GAO Yuan
	LIU Hao
	MU Xiao-jing
	QU Ni-ni
	QIN Yi-bing

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GAO Yuan,LIU Hao,MU Xiao-jing, et al. Clinical effect of Fuzheng Huazhuo Decoction in the treatment of elderly patients with drug-resistant bacteria pneumonia qi deficiency phlegm turbidity obstructing lung syndrome[J]. 中国当代医药, 2021, 28(5): 206-210.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2021/V28/I5/206

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