结核病合并艾滋病感染患者抗结核治疗依从性及其影响因素分析

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Abstract Objective To explore the current status of the compliance of tuberculosis (TB) patients with acquired immune deficiency syndrome (AIDS) infection and its influencing factors,and to provide references for methods to improve the compliance of TB therapy.Methods A total of 78 patients with TB combined with AIDS were admitted to the Fifth People′s Hospital of Ganzhou City from January 2017 to December 2019 were selected as the research subjects.The self-designed questionnaire on compliance of TB and AIDS patients with anti-TB treatment was used to conduct the investigation,includs social demographical characteristics and anti-TB treatment compliance,and the influencing factors of anti-TB treatment compliance were discussed.Results Among 78 patients,42 patients (53.9%)had good compliance with anti-TB treatment.Univariate analysis indicated that there were statistically significant differences in the good compliance rate of anti-TB treatment among different marital status,economic status,cultural background,adverse drug reactions and TB awareness (P＜0.05).Multivariate analysis displayed economic status (β=-0.685,OR=0.245,95%CI=0.103-0.687),adverse drug reactions (β=0.759,OR=2.151,95%CI=1.654-3.587),awareness of TB (β=-0.524,OR=0.352,95%CI=0.214-0.864) were independent influencing factors for the compliance of TB patients with AIDS (P＜0.05).Among them,good economic status and high awareness of TB were protective factors for compliance with anti-TB treatment,and adverse drug reaction was a influencing factor for compliance with anti-TB treatment.Conclusion TB patients combined with AIDS infection generally display poor compliance with anti-TB treatment.Among them,economic status,adverse drug reactions,and awareness of TB are independent risk factors affecting compliance with anti-TB treatment.

Key words： Tuberculosis;Acquired immune deficiency syndrome;Anti-tuberculosis Treatment compliance Influencing factors

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