抗苗勒管激素和胰岛素抵抗在多囊卵巢综合征中的应用

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Abstract Objectives To explore the characteristics and application values of serum anti-Müllerian hormone (AMH)and insulin resistance (IR) in patients with polycystic ovary syndrome (PCOS).Methods A retrospective analysis of 479 infertile patients who were treated in Dalian Maternal and Child Health Hospital from December 2018 to October 2019 was performed.In the research,patients diagnosed as PCOS were considered as PCOS group (315 cases),and other infertile patients were regarded as the control group (164 cases).Moreover,on the basis of the existence of IR,patients with PCOS were divided into PCOS-IR group (111 cases) and PCOS-NIR group (204 cases).The differences and significance of the ages,AMH,total testosterone (T),luteinizing hormone (LH),follicle stimulating hormone (FSH),estradiol(E2),triglyceride (TG),high density lipoprotein (HDL) and low density lipoprotein (LDL) were compared among three groups.Results The values of AMH,T,LH,E2,BMI,HOMA-IR,TG,LDL of PCOS group were higher than those of the control group,which were statistically significant (P＜0.05).FSH and HDL between the two groups were not statistically significant (P＞0.05).BMI,AMH,TG of PCOS-IR group were higher than those of PCOS-NIR group and the control group,which were statistically significant (P＜0.05).HDL of PCOS-IR group was lower than that of PCOS-NIR group and the control group,which was statistically significant (P＜0.05).LDL of PCOS-IR group was higher than that of the control group,which was statistically significant (P＜0.05).AMH,TG and LDL of PCOS-NIR group were higher than those of the control group,which were statistically significant (P＜0.05),and the differences of BMI and HDL between the two groups were not statistically significant (P＞0.05).Conclusions The level of AMH of patients with PCOS is significantly higher than that of patients of non-PCOS,which has a guiding significance for clinical diagnosis.insulin resistance can aggravate the abnormal lipid metabolism of PCOS,which should be paid great attention to and actively intervened in the therapy of patients with PCOS.

Key words： Anti-Müllerian hormone Polycystic ovary syndrome Insulin resistance Metabolism

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