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| Application effect of Dexmedetomidine combined with Etomidate in painless gastrointestinal endoscopy and its influences on stress response in the elderly |
| ZHAO Jing |
| Department of Anesthesiology,Huludao Central Hospital,Liaoning Province,Huludao 125000,China |
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Abstract Objective To explore the application effect of Dexmedetomidine combined with Etomidate in painless gastrointestinal endoscopy and its influences on stress response in the elderly.Methods A total of 92 elderly patients undergoing gastrointestinal endoscopy in Huludao Central Hospital from May 2018 to May 2019 were selected as the research subjects.The control group was given Etomidate,while observation group was given Dexmedetomidine combined with Etomidate for anesthesia.The levels of cortisol (Cor),aldosterone (ALD),angiotensin Ⅱ(AT-Ⅱ) before examination,after 5 minutes of examination and at 1 hour after examination,recovery time of spontaneous breathing,recovery time and extubation time after withdrawal,scores of Ramsay sedation and visual analogue scale (VAS) at 1 hour after examination,and the occurrence of adverse reactions during examination were compared between the two groups.Results The levels of stress indicators in the observation group were lower than those in the control group at 5 min and 1 hour after examination,and the differences were statistically significant (P＜0.05).At 1 hour after the examination,Ramsay sedation score in the observation group was higher than that in the control group,VAS score was lower than that in the control group,the differences were statistically significant (P＜0.05).During the examination,the total incidence of adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant (P＜0.05).Conclusion The application of Dexmedetomidine combined with Etomidate in elderly painless gastroenteroscopy can play a better sedative and analgesic effect,and alleviate the stress response of patients and reduce the incidence of adverse reactions.
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